CN115998518A - Application of magnesium sulfate in preparing scrotum cooling material - Google Patents
Application of magnesium sulfate in preparing scrotum cooling material Download PDFInfo
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- CN115998518A CN115998518A CN202211564649.7A CN202211564649A CN115998518A CN 115998518 A CN115998518 A CN 115998518A CN 202211564649 A CN202211564649 A CN 202211564649A CN 115998518 A CN115998518 A CN 115998518A
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- scrotum
- cooling
- magnesium sulfate
- temperature
- preparing
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 title claims abstract description 60
- 238000001816 cooling Methods 0.000 title claims abstract description 60
- 210000004706 scrotum Anatomy 0.000 title claims abstract description 45
- 229910052943 magnesium sulfate Inorganic materials 0.000 title claims abstract description 30
- 235000019341 magnesium sulphate Nutrition 0.000 title claims abstract description 30
- 239000000463 material Substances 0.000 title claims abstract description 22
- 239000000945 filler Substances 0.000 claims description 3
- 210000000260 male genitalia Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000004806 packaging method and process Methods 0.000 abstract description 2
- 210000001550 testis Anatomy 0.000 description 10
- 238000012360 testing method Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010000060 Abdominal distension Diseases 0.000 description 3
- 230000021595 spermatogenesis Effects 0.000 description 3
- 201000004822 varicocele Diseases 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000109329 Rosa xanthina Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000002082 anti-convulsion Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 206010025226 lymphangitis Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an application of magnesium sulfate in preparing scrotum cooling materials, wherein the scrotum cooling materials are formed by packaging filling materials containing magnesium sulfate in a permeable bag to form cooling bags, and each bag contains 20-50 g of cooling bags. According to the technical scheme, magnesium sulfate is adopted as the scrotum cooling substance, the substance is harmless to scrotum skin, the scrotum temperature can be reduced by 1.5-2 ℃, the constant temperature can reach 4-6 hours, the scrotum temperature can be effectively relieved, the sperm production is promoted, and the scrotum cooling substance has important medical significance.
Description
Technical Field
The invention belongs to the technical field of medicine, and particularly relates to application of magnesium sulfate in preparation of scrotum cooling materials.
Background
It is well known that testis is a male sexual organ, and an important role thereof is the sperm produced, which is a basic condition for human fertility. Sperm occurs at a temperature that is lower than the temperature of the human body.
Based on this, there are various approaches and patent studies in the related art, which have attempted to promote male spermatogenesis by lowering scrotal temperature. In a comprehensive view, the researches are all through a physical cooling method, required cooling apparatuses are complicated, continuous cooling is difficult, temperature regulation and control are difficult to be constant, and practical operability is poor.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems in the related art to some extent. Therefore, the invention aims to provide an application of magnesium sulfate in preparing scrotum cooling materials.
In order to achieve the above purpose, the invention provides an application of magnesium sulfate in preparing scrotum cooling materials.
According to one embodiment of the invention, the scrotum cooling material is a dressing sheet, and the dressing sheet is attached to the surface of the scrotum.
According to one embodiment of the invention, the scrotum cooling material is formed by packaging a filling material containing magnesium sulfate in a permeable bag to form cooling bags, and each bag contains 20 to 50g of cooling bags.
According to one embodiment of the invention, the cooling pack is fixed to the male underpants in the area corresponding to the male genitals.
Through the technical scheme, the inventor of the invention adopts magnesium sulfate as the scrotum cooling substance for the first time, the substance has no harm to scrotum skin, the scrotum temperature can be reduced by 1.5-2 ℃, the constant temperature can reach 4-6 hours, the scrotum temperature can be effectively relieved, the sperm production is promoted, and the invention has important medical significance.
Additional features and advantages of the invention will be set forth in the detailed description which follows.
Drawings
Fig. 1 is a graph of detected temperature scatter (abscissa is labeled for population, and ordinate is the temperature values detected for different time periods).
Detailed Description
The following describes specific embodiments of the present invention in detail. It should be understood that the detailed description and specific examples, while indicating and illustrating the invention, are not intended to limit the invention.
The present invention has been completed based on the following findings and studies by the inventors.
In the related art, there are various approaches and patent studies in an attempt to promote male spermatogenesis by lowering scrotal temperature. In a comprehensive view, the researches are all through a physical cooling method, required cooling apparatuses are complicated, continuous cooling is difficult, temperature regulation and control are difficult to be constant, and practical operability is poor.
The application provides an application of magnesium sulfate in preparing scrotum cooling materials.
In one embodiment of the invention, the scrotum cooling material is a dressing sheet, and the dressing sheet is attached to the surface of the scrotum. That is, the dressing sheet can be made of magnesium sulfate, and in application, the dressing sheet is directly attached to the surface of scrotum, so that the dressing sheet is convenient to use.
In another embodiment of the invention, the scrotum cooling material is packaged in a permeable bag by a filling material containing magnesium sulfate to form cooling bags, and each bag contains 20 to 50g of cooling bags. That is, in this embodiment, magnesium sulfate may be used as a filler, and the filler may be packaged in a bag, such as a cotton bag or a nonwoven bag, to form a cooling bag.
For example, in a specific application, the cooling pack may be secured to the male underpants in an area corresponding to the male genitals, for example by means of adhesive. That is, the cooling bag can be fixed on the male underpants to form the cooling underpants, and the cooling underpants are very convenient to wear and use.
The inventor of the invention adopts magnesium sulfate as a scrotum cooling substance for the first time, the substance has no harm to scrotum skin, can reduce the scrotum temperature by 1.5-2 ℃, can reach constant temperature for 4-6 hours, can effectively relieve the scrotum temperature, promotes sperm production, and has important medical significance.
Examples:
1) Experiment design:
the group-entering population is 16 men 20-60 years old, 12 patients with varicocele are ultrasonically diagnosed in the 16 men, and 10 patients with single-side or double-side scrotum distention and distention discomfort are in the 12 persons for a long time.
2) The scrotum temperature of the subject is monitored by an electronic thermometer, and the test unit is the temperature (DEG C).
3) The magnesium sulfate is packaged into cooling bags in bags, and each bag is 25g. The cooling bag is fixed on the male underpants to form cooling underpants, and the cooling underpants are placed for 5 hours.
4) And continuously detecting scrotum temperature by adopting an electronic thermometer, and observing whether local skin has burn allergy or not after the experiment is finished.
5) Data were counted using SPSS25.0 statistical software and data comparison was performed using paired t-test. Assume that the significance level of the test α=0.001.
6) Results:
at present, the scrotum temperature measurement data of a human body are not queried from the literature. For scrotum temperature detection herein, scrotum temperature is between 36.3-37.5 ℃ (36.89.+ -. 0.43) °c). After wearing the cooling underpants, the scrotum temperature is reduced to 35.3-36.0 ℃, and the lower temperature is about 1.5-2.0 ℃ (table 1).
TABLE 1 scrotum temperature test Table (temperature units:. Degree.C.)
From the statistical detection results, there is a significant statistical difference between the initial temperature and the detection results after wearing the cooling underpants, while the detection temperatures after wearing the cooling underpants have no significant statistical difference. From the temperature scatter diagram of fig. 1, the difference between the initial temperature and the detected temperature is obvious, while there is no obvious difference between the temperature after 5min after wearing the cooling underpants and 5h after wearing the cooling underpants. The scrotum temperature after wearing the cooling underpants is relatively constant, and no obvious fluctuation occurs.
TABLE 2 paired t-test results
From the detected temperature scatter plot of fig. 1, the initial temperature T0 is much higher than the other time period monitored temperatures; after the cooling pants are worn, the detected temperature is obviously reduced, the temperature lines are overlapped, and the temperature after the cooling pants are worn is prompted to be relatively constant.
For patients with varicocele complicated with scrotum distention, the discomfort symptoms are rapidly relieved 10-15min after wearing the cooling trousers.
From domestic and foreign data, the influence of high temperature on testis function has become a consensus that low temperature is beneficial to testis function maintenance and spermatogenesis. Thus, there have been many studies on cooling materials for scrotum. In view of the cooling materials in the literature, electronic devices, ice devices and the like are often adopted, and the feasibility and the practicability of the devices are not ideal.
Magnesium sulfate is used as a medical material and has antidiarrheal, cholagogic and anticonvulsive effects. For mastitis and lymphangitis, 50% magnesium sulfate solution is used for hot compress on affected parts, so that the traditional Chinese medicine composition is beneficial to diminishing inflammation and removing swelling.
For the cooling effect of testes, no related report is seen.
From the data obtained by the inventor, the magnesium sulfate has remarkable cooling effect on scrotum. After the material is used, the testis temperature can be reduced by 1.5-2 ℃ within 5 minutes; in the time period of wearing the cooling trousers, the temperature is basically continuous, and the change is not obvious. This has a good regulatory effect on maintaining the physiological temperature of the testes. From a physiological point of view, this temperature is advantageous for maintenance of testis function, since both high temperature (temperature & gt 37.3 ℃) and low temperature (temperature & lt 34.0 ℃) are detrimental to the testis.
From the principle of action, magnesium sulfate may form a tiny cavity for temperature regulation, and after moisture on the scrotum surface is absorbed by magnesium sulfate, the moisture is locally gasified to cause temperature reduction, and the relatively constant low temperature may form a microenvironment favorable for testis function.
Magnesium sulfate is used as a relatively wide reagent for clinical medical use, can be used for intravenous administration, anticonvulsant administration and antidiarrheal administration, and can be used for treating mastitis by external use, so that the safety of the magnesium sulfate to human bodies is relatively ensured. From the treatment obtained by the inventor, after the patient uses magnesium sulfate, no symptoms such as skin frostbite, local allergy, gastrointestinal discomfort and the like appear, thus indicating that the safety of the magnesium sulfate is quite reliable.
From the environmental point of view, since magnesium is one of the main components of chlorophyll, magnesium sulfate is used as a fertilizer in agriculture, and is generally used for potted plants or magnesium-deficient crops such as tomatoes, potatoes, roses, etc. So from the environmental protection point of view, the magnesium sulfate does not pollute the environment.
For patients with symptoms accompanied by varicocele, uncomfortable symptoms can be relieved rapidly by wearing the cooling trousers.
In conclusion, the magnesium sulfate can be used as a medical compound for preparing testis cooling materials.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Moreover, any combination of the various embodiments of the invention can be made without departing from the spirit of the invention, which should also be considered as disclosed herein.
Claims (4)
1. The application of magnesium sulfate in preparing scrotum cooling material.
2. The use according to claim 1, wherein the scrotum cooling material is a dressing sheet, and the dressing sheet is attached to the scrotum surface.
3. The use according to claim 1, wherein the scrotum cooling material is packaged in a permeable bag by a filler containing magnesium sulfate to form cooling packs, each pack containing 20 to 50g of cooling packs.
4. The use according to claim 3, wherein the cooling pack is secured to the male underpants in the area corresponding to the male genitalia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211564649.7A CN115998518A (en) | 2022-12-07 | 2022-12-07 | Application of magnesium sulfate in preparing scrotum cooling material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211564649.7A CN115998518A (en) | 2022-12-07 | 2022-12-07 | Application of magnesium sulfate in preparing scrotum cooling material |
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| Publication Number | Publication Date |
|---|---|
| CN115998518A true CN115998518A (en) | 2023-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211564649.7A Pending CN115998518A (en) | 2022-12-07 | 2022-12-07 | Application of magnesium sulfate in preparing scrotum cooling material |
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| Country | Link |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2681717Y (en) * | 2004-03-08 | 2005-03-02 | 孟永生 | Pants with cooling bag |
| CN108743006A (en) * | 2018-06-25 | 2018-11-06 | 阜阳徽远生物科技有限公司 | A kind of medical salt deposited bag and its manufacturing method |
| CN208130093U (en) * | 2017-12-04 | 2018-11-23 | 南京悦安医疗科技有限公司 | A kind of magnesium sulfate hydrogel application |
| CN210903627U (en) * | 2019-08-16 | 2020-07-03 | 中国人民解放军联勤保障部队第九二○医院 | Cooling and swelling-diminishing nasal paste |
| CN211382140U (en) * | 2019-11-13 | 2020-09-01 | 广州耀远实业有限公司 | Scrotum cold compress subsides |
| CN214549809U (en) * | 2020-12-23 | 2021-11-02 | 河南贺江医疗科技有限公司 | Medical cold compress subsides |
| CN214967427U (en) * | 2021-04-08 | 2021-12-03 | 河池市人民医院 | Scrotum edema rehabilitation device |
-
2022
- 2022-12-07 CN CN202211564649.7A patent/CN115998518A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2681717Y (en) * | 2004-03-08 | 2005-03-02 | 孟永生 | Pants with cooling bag |
| CN208130093U (en) * | 2017-12-04 | 2018-11-23 | 南京悦安医疗科技有限公司 | A kind of magnesium sulfate hydrogel application |
| CN108743006A (en) * | 2018-06-25 | 2018-11-06 | 阜阳徽远生物科技有限公司 | A kind of medical salt deposited bag and its manufacturing method |
| CN210903627U (en) * | 2019-08-16 | 2020-07-03 | 中国人民解放军联勤保障部队第九二○医院 | Cooling and swelling-diminishing nasal paste |
| CN211382140U (en) * | 2019-11-13 | 2020-09-01 | 广州耀远实业有限公司 | Scrotum cold compress subsides |
| CN214549809U (en) * | 2020-12-23 | 2021-11-02 | 河南贺江医疗科技有限公司 | Medical cold compress subsides |
| CN214967427U (en) * | 2021-04-08 | 2021-12-03 | 河池市人民医院 | Scrotum edema rehabilitation device |
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