CN1159955A - Ultraviolet light quantum intravascular irradiation therapeutic machine - Google Patents
Ultraviolet light quantum intravascular irradiation therapeutic machine Download PDFInfo
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- CN1159955A CN1159955A CN 96115162 CN96115162A CN1159955A CN 1159955 A CN1159955 A CN 1159955A CN 96115162 CN96115162 CN 96115162 CN 96115162 A CN96115162 A CN 96115162A CN 1159955 A CN1159955 A CN 1159955A
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Abstract
An endovascular irradiation therapeutic apparatus using ultraviolet light quantum is composed of light source, optical fibre system and resided optical needle, and features use of light source with wavelength from 180 nm to 400 nm and use of silica glass in light channel, which can transmit ultraviolet light. Its advantages are simple operation, low cost and reducing infection chance during treatment.
Description
The present invention relates to medical apparatus and instruments, provide a kind of instrument that can carry out the ultraviolet light quantum irradiation treatment in vivo to blood circulation especially, promptly a kind of ultraviolet light quantum intravascular irradiation therapeutic machine.
Use ultraviolet light quantum external carry out the human body hemocyte is shone, to reach the purpose of preventing and curing diseases, just be applied to clinical as far back as the beginning of this century, be referred to as UBIO (Ultraviolet BloodIrradiation and Oxygenation is called for short UBIO), before the antibiotic invention 20～thirties of this century, UBIO is at first popularized in the U.S., and nineteen twenty-eight Hancock VK etc. rescues two examples because of pyemia miscarriage and the dying patient of brain abscess in the clinical ultraviolet radiation autoblood transfusion method of successfully using first.From then on cause the whole world to the concern of this method, and it is widely used in various pyogenic infections, viral and treatment that viroid catches, this method of clinical proof can prevent the diffusion of pyemia, reduces postoperative pyogenic infection complication and mortality rate.Even drug-fast staphylococcemia patient also has obvious curative effects to sulfanilamide.After the antibiotic invention, because of its extensive application clinically, this therapy was once once forgotten by what is said or talked about, but owing to being on the increase of antibiotics resistance bacterial strain, though have many novel antibiotics to come out, because of producing drug resistance or side effect such as allergy, organ toxicity and dysbacteriosis being arranged, and invalid to virus, cause this therapy to cause domestic and international clinicist's attention once more.The process of UBIO is to extract patient self venous blood, each 200ml is grown up, children's is by per kilogram of body weight 2～4ml, about 30～the 50ml of infant, the aseptic blood bag of packing into, the 2.5% Chinese holly rubber acid sodium anticoagulant of blood drawing total amount 1/5～1/4 is arranged in the bag, place UBI oxygenation therapeutic instrument afterwards, through ultraviolet radiation oxygenation simultaneously 3～5 minutes, continued logical oxygen 5 minutes, after being fed back into aseptic blood bag, feed back to the patient through vein, ultraviolet wavelength is 240～360nm again, exposure dose is generally 10J/cm2 blood, the next day, operate once, and 4～6 times is a course of treatment, can reach at most 20 times.One of the existence at present of this therapy is that therapeutic process is cumbersome than distinct issues, and the chance that infection occurs is many.It is higher to treat cost simultaneously.
The blood vessel internal recycle blood irradiation treatment that present application light quantum carries out in vivo has only low-yield He-Ne Intravascular Laser Irradiation on Blood hemotherapy (In travascularlaser Irradiation of Blood simply claim ILIB), in China is nineteen ninety to lead development by wide continent first professor Wang Tiedan of military region university, be applied to clinical 3～4 years of having only, this therapy apparatus has obtained national patent.Being characterized in adopting wavelength is the infrared ray of 632.8nm, and its biological action wants little many corresponding to ultraviolet certainly.
The object of the present invention is to provide a kind of ultraviolet light quantum intravascular irradiation therapeutic machine, it is simple to operate, can reduce the infection chance in the therapeutic process, reduces the treatment cost.
The invention provides a kind of ultraviolet light quantum intravascular irradiation therapeutic machine, mainly by light source 1, optical fiber light-guiding system 2 and indwelling laser accunputure 3 serial connections constitute, and it is characterized in that:
(a) select the light source of wave-length coverage for use at 180nm～400nm;
(b) all light-pathes all adopt the silex glass of ultraviolet light to make.
Can between light source 1 and optical fiber 2, add filter 4 according to the different of patient's disease and treatment needs.Or the output light intensity actuator 5 that adding is made up of quartz lens between light source 1 and the optical fiber 2.
They three major parts that comprise of ultraviolet light quantum intravascular irradiation therapeutic machine provided by the present invention specifically describe as follows:
1. light-source system
What the present invention adopted is the ultraviolet source of 180～400nm, by 1979 WHO (World Health Organization (WHO)) standard, ultraviolet is divided into:
Short wave ultraviolet 180～280nm
Ultraviolet B radiation 280～320nm
Long wave ultraviolet 320～400nm
Wherein the ultraviolet main biological action of each section is different, and short wave ultraviolet is used for sterilization, in, the long-wave band ultraviolet is normal employing the on the clinical treatment.Conventional lighting sources mainly contains following several:
1. water-cooled high voltage mercury lamp (structure is seen Fig. 2): be whole wave band ultraviolet, wave-length coverage 230～400nm, and based on the long and medium wave ultraviolet, be comparatively ideal wave band on the clinical treatment, but because water-cooling system is arranged, equipment is complicated, price is expensive.
2. cold light low pressure mercury lamp: (structure is seen Fig. 3): wave-length coverage 253.7～400nm is based on the short-wave band ultraviolet, and bactericidal action is strong, a little less than antiinflammatory and other effect relatively, but owing to there is not water-cooling system, equipment is simple, low price, and output light source intensity instability.
3. ultraviolet laser (continuously): can only produce short wave ultraviolet, wavelength is single, and wherein argon ion (Ar) produces the 244nm ultraviolet light, and helium cadmium (He-Cd) produces the 235nm ultraviolet light.
2. optical fibers light-conducting system: main Bao Quan
The union joint 21 (structure is seen Fig. 4) of-----link to each other: the metal sleeve that is band bayonet socket and screw thread with light source;
-----silicon fiber 22 (structure is seen Fig. 5): expand at two ends, and wherein an end and union joint 21 adapt, and the threaded and tail end of the other end has ring-type to protrude 23, so that laser accunputure 3 is positioned;
-----with blood vessel in keep somewhere the union joint 34 (structure is seen Fig. 6) that laser accunputure 3 links to each other: be tapped metal sleeve, tail end band spring pressuring plate.
3. keep somewhere the laser accunputure and the puncture trocar
Keep somewhere laser accunputure 3 (structure is seen Fig. 7): the ring-type of butt end and silicon fiber 22 tail ends is protruded 23 and is adapted, and thin end can insert in the trocar 6.
Puncture is with the trocar 6 (structure is seen Fig. 8): have commercially availablely, comprise metal inner core 61 and keep somewhere the interior overcoat 62 of blood vessel.
By ultraviolet light quantum intravascular internal therapy machine provided by the present invention, directly introduce ultraviolet light quantum in the body, reduced the link in many former Therapeutic Method, not but still kept many excellent curative effect in the former therapy, and simple to operate, reduced infection chance, shortened total treatment time, reduced the treatment cost, also be easier to be accepted by the patient.Describe the present invention below by embodiment.
Accompanying drawing 1 ultraviolet light quantum intravascular irradiation therapeutic machine theory diagram
Accompanying drawing 2 water-cooled high voltage mercury lamp structural principle sketch maps
Accompanying drawing 3 cold light low pressure mercury lamp structural principle sketch maps
The union joint structural representation that accompanying drawing 4 links to each other with light source
Accompanying drawing 5 silicon fiber structural representations
The union joint structural representation that accompanying drawing 6 links to each other with indwelling laser accunputure in the blood vessel
Accompanying drawing 7 is kept somewhere the laser accunputure structural representation
Accompanying drawing 8 puncture trocar design sketch maps
9 one kinds of ultraviolet light source intravascular irradiation therapeutic machines of accompanying drawing structural representation
10 1 kinds of water-cooled whole wave band ultraviolets of accompanying drawing light source intravascular irradiation therapeutic machine structural representation
The ultraviolet intravascular irradiation therapeutic machine light source junction structural representation of 11 1 kinds of simplification of accompanying drawing
Accompanying drawing 12 sees through the blood vessel path analysis for ultraviolet light
Embodiment 1
Apparatus structure is seen accompanying drawing 9, and by light source 1, optical fiber light-guiding system 2 keeps somewhere laser accunputure 3 serial connections and forms, the pure quartz fiber optics of selecting for use Nanjing Glass Fibre Research and Design Institute the 3rd institute to produce, and other parameter and experimental result are as follows:
(1) ultraviolet light quantum intravascular internal therapy machine has related parameter
1. light source: employing be water-cooled whole wave band ultraviolet lamp, luminous power 200W wave-length coverage 254-436nm
2. fibre system: silica fibre diameter 0.9mm, length 1.5M, the light source link with keep somewhere the laser accunputure link by the figure design.Optical fiber parameter sees through wave-length coverage (250～400nm) every meter transmitance 85-98%.
3. vascular puncture and keep somewhere laser accunputure
The vascular puncture trocar adopts the U.S. to produce diameter 1.0mm, and long 55mm keeps somewhere laser accunputure diameter 0.9mm, inner edge silica fibre diameter 0.7mm.
4. detect the ultraviolet light quantum output intensity
(1) light intensity is measured:
360nm wave band before the treatment after testing, output are 20.5 μ w treatment after hour, and it is 13.3 μ w that optical fiber is transferred to blood vessel (preceding have blood film) output
(2) biological dose (MED) is measured
Adopt Kromayer Hanovia 10S type water-cooled whole wave band ultraviolet lamp to compare, adopt quartzy treatment head (long 90cm No. 7, diameter 1.0cm) 1 time that biological dose is used after measured, ultraviolet light quantum endovascular treatment machine (minimum light intensity) was compared according to how approximately with 15～20 times of times.
(2) zoopery
Experiment purpose: understand the operation possibility of this therapy apparatus and stability, the reliability of every physical parameter, preliminary observation influences situation to some of laboratory animal
1. operating process:
(1). open light source switch, gave heat 10 minutes
(2) with the sterilization residual liquid on the physiological saline solution flushing indwelling laser accunputure, standby.
(3) get thicker rabbit ear vein behind the conventional skin degerming along the vein traveling, will puncture and insert blood vessel, see that clamping sleeve bobbin front end is extracted the metal nook closing member out behind the blood back, trocar plastic outer sleeve is kept somewhere in blood vessel with the trocar.
(4) keeping somewhere laser accunputure in the blood vessel that will be standby inserts in endovascular trocar plastic wrapper.
(5) open the output switch
(6) adjust indwelling laser accunputure angle, determine that errorless back is conventional fixing.
(7) after treatment finishes, trocar overcoat and indwelling laser accunputure were together transferred to hemostasis by compression 3 minutes, treatment finishes.
2. zoopery material method
Get 6 of the purebred health large ear rabbits in Beijing, 2.75～3.0 kilograms of body weight, detect routine blood test and hemorheology index before the female begin treatment, anaesthetize through hydrogen amine ketone before the treatment of animals, press aforesaid operations and will keep somewhere laser accunputure insertion rabbit ear vein blood vessel, 60 minutes treatment times, once a day, 5 times is a course of treatment, detects routine blood test and hemorheology indication after treatment finishes again.
3. zoopery result
Obvious change is not seen in (1) 6 Sanguis Leporis seu oryctolagi routine examination before and after the treatment.
(2) rabbit ear area of illumination blood vessel is treated in treatment under back naked eyes and the mirror and is not seen blood coagulation, and thrombosis waits other change.Get six rabbit topical therapeutic district ear veins after the treatment and do not see also that through pathologic finding damage changes.
(3) hemorheology index change situation sees Table
Value mean (X) before and after the 6 routine Sanguis Leporis seu oryctolagi stream rheology treatments
| Before the treatment (X) | Treatment back (X) | Difference (X) | ||
| Whole blood viscosity | Low cutting | ????7.11 | ????6.08 | ????1.03 |
| In cut | ????3.83 | ????3.41 | ????0.42 | |
| Height is cut | ????3.37 | ????2.89 | ????0.48 | |
| Plasma viscosity | ????1.28 | ????1.24 | ????0.04 | |
| Packed cell volume | ????38 | ????36.3 | ????2.7 | |
Because routine number is few, can't carry out statistical procedures
4. ultraviolet intravascular irradiation circulation blood, the blood vessel injury situation analysis:
In zoopery, under naked eyes, the mirror and get the rabbit ear at last and carry out pathologic finding, do not see that at the ultraviolet radiation zone blood vessel its reason of damaging change mainly is a blood to due to the ultraviolet good absorption.
To beg for normal person's whole blood to ultraviolet transmitance in order controlling, to have carried out the experiment of ultraviolet blood permeability, the results are shown in following table (is object with the 360nm long wave ultraviolet)
Normal person's whole blood ultraviolet sees through situation whole blood thickness (mm) and records light intensity (mw.cm
2) transmitance
*Reference value
*8.063 100% one deck blood film approximately
* *(0.01-0.02) 4.157 51.6%0.055,0.247 3.1%0.080,0.059 0.73%0.11 0.020 0.25%
* transmitance=record light intensity/reference value * 100%
* reference value: the ultraviolet ray intensity that sees through two pieces of quartz glass sheets that records when not having blood media
* *: the remained blood thickness when several whole bloods compress two piezoids then between two pieces of quartz glass sheets.
Above presentation of results ultraviolet is quite low to the transmitance of whole blood, and the thickness of a hair thickness (0.07mm) can lose 99% smooth ultraviolet light quantum approximately.Have one section to walk to lean on just and can reach blood vessel wall from treatment situation analysis light in the blood vessel domestic demand in addition, and light almost all has been absorbed will be by this segment distance the time.As shown in figure 12.Laser accunputure quartz 31; Laser accunputure is protected outward and is expanded layer 32; (metal restriction 0.1mm) blood vessel wall 71; Blood vessel interior 72; The beeline that when the light quantum of laser accunputure shines blood vessel wall, need pass through.Mobile abrim whole blood between this segment distance of d in addition.
The calculating of attached d:
If the critical angle θ that optical fiber transfers, with the angle of optical axis be α.Existing known transmission optical fiber, generally speaking its critical angle θ all 70 °～be that 20 ° of light below-10 ° could transmit at in-core therefore more than 80 ° with optical axis included angle α, suppose that α is 20 °, b is 0.1mm.
Be the ultraviolet light quantum leave behind the laser accunputure minimum will through about 3 times to optical fiber external protection thick distance could arrive blood vessel wall, die light quantum when passing through this segment distance by hemocyte basic absorption.
Embodiment 2
Apparatus structure is seen accompanying drawing 10, employing remain water-cooled whole wave band ultraviolet light source, in order to increase output intensity, before optical fiber, designed a convex lens of making by quartz glass as light intensity equalizer,, designed a smooth filter before the light intensity equalizer again for adapting to patient's different syndromes, the one group filter of light filter for changing at any time, can filter the different wave length ultraviolet, protect the coloured optical glass model of paddy for Japan and be respectively UV-22, UV-28, UV-30, UV-32, UV-34, UV-36.
Adopt cold Testudinis low pressure mercury lamp as light source, the junction of light source and optical fiber has also adopted a kind of design of simplification to see accompanying drawing 1, and other is identical with embodiment 1, and this kind design characteristic is that cost is low, is easy to promote.
Adopt Ultra-Violet Laser He-cd as light source, other can be used as the special treatment of medical treatment experiment oar all with embodiment 1.
The UBIO therapy is the ultraviolet radiation that carries out under aerobic condition, the hemocyte irradiation of under non-aerobic condition, carrying out external produce to hemorheological influence, also existing scholar studies, and has drawn and aerobic condition the same conclusion down.Some scholar even think that the UBIO therapy is to improve hemorheological property the best way up to now, the present invention has also tentatively seen improving the effect of blood viscosity by the experiment of 6 rabbits.
The ultraviolet light quantum intravascular internal recycle blood irradiation treatment that the present invention proposes is applied to clinical, has with the UBIO ratio, and is easy and simple to handle as intravenous injection, transfusion) reduces opportunities for contamination, reduce treatment cost (1/2-1/3 that is about the UBIO therapy), patient easily accepts, and helps advantages such as popularization.Except the effect on the external control ischemic cerebrocardiac disease of the application on the severe infections disease is self-evident.
Claims (3)
1. ultraviolet light quantum intravascular irradiation therapeutic machine, mainly by light source (1), optical fiber light-guiding system (2) and put and stay laser accunputure (3) serial connection to constitute is characterized in that:
(a) select the light source of wave-length coverage for use at 180nm～400nm;
(b) all light-pathes all adopt the silex glass of ultraviolet light to make.
2. by the described ultraviolet light quantum intravascular irradiation therapeutic machine of claim 1, it is characterized in that: between light source (1) and optical fiber (2), add filter (4).
3. by claim 1,2 described ultraviolet light quantum intravascular irradiation therapeutic machines is characterized in that: add the output light intensity actuator of being made up of quartz lens (5) between light source (1) and the optical fiber (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96115162 CN1159955A (en) | 1996-03-20 | 1996-03-20 | Ultraviolet light quantum intravascular irradiation therapeutic machine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96115162 CN1159955A (en) | 1996-03-20 | 1996-03-20 | Ultraviolet light quantum intravascular irradiation therapeutic machine |
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| CN1159955A true CN1159955A (en) | 1997-09-24 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU182362U1 (en) * | 2017-07-20 | 2018-08-15 | Виктор Васильевич Фомин | UV irradiator |
| CN110167604A (en) * | 2016-11-30 | 2019-08-23 | 里斯托·科波宁 | Method and apparatus for microbial destruction UV light to be transmitted to target from light source |
| CN113332460A (en) * | 2021-03-30 | 2021-09-03 | 张耀绵 | Ultraviolet C wave treatment method for vitamin C-containing solution |
-
1996
- 1996-03-20 CN CN 96115162 patent/CN1159955A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110167604A (en) * | 2016-11-30 | 2019-08-23 | 里斯托·科波宁 | Method and apparatus for microbial destruction UV light to be transmitted to target from light source |
| RU182362U1 (en) * | 2017-07-20 | 2018-08-15 | Виктор Васильевич Фомин | UV irradiator |
| CN113332460A (en) * | 2021-03-30 | 2021-09-03 | 张耀绵 | Ultraviolet C wave treatment method for vitamin C-containing solution |
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