CN115932308A - Sample adding system, in-vitro diagnostic apparatus and sample adding method - Google Patents

Abstract

The invention discloses a sample adding system, an in-vitro diagnosis analyzer and a sample adding method, wherein the sample adding system of the sample adding system comprises: the sample buffer device comprises a first sample adding device, a second sample adding device and a sample buffer adding device; the first sample adding device is used for sucking a sample from a sample tube at a sample sucking position, and the sample tube is arranged on the sample rack; the sample caching and sampling device is used for caching the sample absorbed by the first sample sampling device; the second sample loading device is used for sucking a sample from the sample caching and loading device and releasing the sample into a reaction cup at a loading position; the sample buffering and sampling device can buffer N samples, N is the integral multiple of the number of sample tubes on each sample rack, and N is a positive integer. The sample adding system shortens the shelf loading period and the shelf unloading period of the sample and shortens the detection period of the sample.

Description

Sample adding system, in-vitro diagnostic apparatus and sample adding method

Technical Field

The invention relates to the technical field of in-vitro diagnosis, in particular to a sample adding system, an in-vitro diagnosis analyzer and a sample adding method.

Background

Currently, in an in vitro diagnostic apparatus, if a detection result of a sample is abnormal, an inspector needs to retest the sample with the abnormal detection result. Therefore, the samples on the shelf in the current batch, that is, the sample shelf (the sample tube is placed in the sample shelf and the sample is placed in the sample tube) which reaches the base of the sample shelf at present, need to wait for outputting the detection result and confirm that the detection result is not abnormal by the inspector before being taken off the shelf, and the samples in the next batch can be taken on the shelf, so that the period of taking the samples on the shelf is longer, and the detection period of the samples is also longer.

In addition, in some in vitro diagnostic apparatuses, in order to shorten the period of sample batch detection, the sample of the current batch is added after the sample is added, and the sample of the next batch is added, so that the detection result of the sample of the current batch is abnormal, and the sample with the abnormal detection result needs to be put on a shelf again, which results in long time for retesting.

In summary, how to complete the sample adding of the sample to shorten the period of putting the sample on the shelf, thereby shortening the detection period of the sample and satisfying the requirement of putting the sample on the shelf rapidly is a problem to be solved urgently by those skilled in the art.

Disclosure of Invention

In view of the above, the present invention provides a sample loading system, an in vitro diagnostic analyzer and a sample loading method, so as to shorten the loading period of a sample, thereby shortening the detection period of the sample and satisfying the requirement of rapid loading of the sample.

In order to achieve the purpose, the invention provides the following technical scheme:

a sample application system for an in vitro diagnostic analyzer, the sample application system comprising: the sample buffer device comprises a first sample adding device, a second sample adding device and a sample buffer adding device;

the first sample adding device is used for sucking a sample from a sample tube at a sample sucking position, and the sample tube is arranged on a sample rack;

the sample caching and sample adding device is used for caching the sample absorbed by the first sample adding device;

the second sample loading device is used for sucking the sample from the sample caching and loading device and releasing the sample into a reaction cup at a loading position;

the sample caching and sampling device can cache N samples, N is an integral multiple of the number of the sample tubes on each sample rack, and N is a positive integer.

Optionally, the first sample adding device is used for sucking a first set amount of sample from the sample tube;

the second sample loading device is used for sucking a second set amount of the sample from the sample caching loading device;

the first set quantity is not less than the sum of the quantity required by the sample to finish all detection items and the quantity required by the sample retest, and the second set quantity is the quantity required by the sample to finish a single detection item or the quantity required by the sample retest;

the time for buffering N-1 samples by the sample buffering and sample adding device is not less than the time for finishing all detection items and retesting of any one sample, and N is more than or equal to 2.

Optionally, the first sample loading device comprises: the sample container, the sample conveying assembly and the first sample adding assembly;

the sample caching and sample adding device comprises a sample caching disc and a grabbing component;

the first sample loading component is used for sucking the first set amount of sample from a sample sucking position and releasing the first set amount of sample into the sample container at a buffer loading position, and the sample conveying component is used for conveying the sample container between the buffer loading position and a position to be buffered;

the sample buffer disk is used for placing the sample containers, and the grabbing component is used for moving the sample containers of the to-be-buffered positions to the sample buffer disk and moving the sample containers on the sample buffer disk out.

Optionally, the first sample loading assembly comprises: the device comprises a first sample adding needle, a first bracket and a first sample adding needle movement component arranged on the first bracket;

wherein the first sample adding needle is used for sucking and releasing the sample;

and the first sample adding needle motion assembly drives the first sample adding needle to reciprocate between the sample sucking position and the buffer sample adding position.

Optionally, the sample loading system further comprises:

the first detector is used for detecting whether the sample sucking position has the sample tube or not;

the second detector is used for detecting whether the first sampling needle reaches the sample sucking position or not;

a third detector, configured to detect whether the first sampling needle reaches the cache sampling position;

a fourth detector for detecting whether the sample container reaches the buffer sample adding position;

a first controller, configured to control the first sample application needle moving assembly to drive the first sample application needle to move to the sample suction position when the first detector detects that the sample suction position has the sample tube; when the second detector detects that the first sample application needle reaches the sample suction position, the first controller is used for controlling the first sample application needle to suck the sample and controlling the first sample application needle movement assembly to drive the first sample application needle to move to the cache sample application position; the first controller is configured to control the first sample application needle to release the sample when the third detector detects that the first sample application needle reaches the buffer sample application position and the fourth detector detects that the sample container reaches the buffer sample application position.

Optionally, the sample buffer disk is provided with placing holes for placing the sample containers, and the placing holes are distributed in sequence along the circumferential direction of the sample buffer disk;

the sample caching and sample adding device further comprises a caching disc horizontal moving assembly, and the caching disc horizontal moving assembly is used for driving the sample caching disc to rotate in a horizontal plane so as to enable each placing hole to move to a caching position in sequence;

the grabbing component is used for moving the sample container to be cached to the placing hole in the caching position.

Optionally, the grasping assembly includes:

a grip for gripping and releasing the sample container;

and the gripper moving component drives the gripper to move back and forth between the position to be cached and the caching position.

Optionally, the gripper motion assembly comprises: the gripper horizontal movement assembly, the gripper lifting movement assembly and the gripper telescopic movement assembly are arranged on the gripper horizontal movement assembly;

the gripper is arranged on the gripper telescopic motion assembly, and the gripper telescopic motion assembly is used for driving the gripper to move along the horizontal direction;

the hand grip telescopic motion assembly is arranged on the hand grip lifting motion assembly, and the hand grip lifting motion assembly is used for driving the hand grip telescopic motion assembly to lift;

the gripper lifting motion assembly is arranged on the gripper horizontal motion assembly, and the gripper horizontal motion assembly is used for driving the gripper lifting motion assembly to rotate in the horizontal plane.

Optionally, the rotational axis of the gripper lifting motion assembly and the rotational axis of the sample buffer tray are collinear.

Optionally, the sample buffer sample adding device is provided with a buffer sampling position, and the buffer disc horizontal movement assembly is further configured to drive the sample buffer disc to rotate in a horizontal plane so that each placing hole is sequentially moved to the buffer sampling position; the second sample adding device is used for sucking the sample from the cache sampling position.

Optionally, the second sample loading device comprises: the second sample adding needle, the second bracket and a second sample adding needle moving assembly are arranged on the second bracket;

wherein the second sample adding needle is used for sucking and releasing the sample;

and the second sample adding needle motion assembly is used for driving the second sample adding needle to reciprocate between the buffer sampling position and the sample adding position.

Optionally, the second loading needle moving assembly comprises: the second sample adding needle horizontal movement component and the second sample adding needle lifting movement component;

the second sample adding needle horizontal movement component is used for driving the second sample adding needle to rotate in a horizontal plane;

the second sample adding needle horizontal movement assembly is arranged on the second support in a liftable mode, and the second sample adding needle lifting movement assembly is arranged on the second support and used for driving the second sample adding needle horizontal movement assembly to lift.

Optionally, the sample loading system further comprises:

a fifth detector for detecting whether the sample container on the sample cache disk reaches the cache sample bit;

a sixth detector, configured to detect whether the second sampling needle reaches the cache sampling location;

a seventh detector for detecting whether the second sample adding needle reaches the sample adding position;

an eighth detector for detecting whether the sample addition site has a reaction cup;

a second controller for controlling the buffer tray horizontal motion assembly to drive the sample buffer tray to rotate in a horizontal plane if the fourth detector does not detect that the sample containers on the sample buffer tray reach the buffer loading position and the fifth detector does not detect that the sample containers on the sample buffer tray reach the buffer sampling position; when the fourth detector detects that the sample container on the sample cache disk reaches the cache loading position, the second controller is used for controlling the cache disk horizontal movement assembly to stop driving for a first preset time; the second controller is used for controlling the buffer disk horizontal motion assembly to stop driving for a second preset time when the fifth detector detects that the sample container on the sample buffer disk reaches the buffer sampling position;

a third controller, configured to control the second sampling needle moving component to drive the second sampling needle to move to the buffer sampling position when the fifth detector detects that the sample container on the sample buffer tray reaches the buffer sampling position; when the sixth detector detects that the second sampling needle reaches the cache sampling position, the third controller is configured to control the second sampling needle to suck the second set amount of sample and to control the second sampling needle moving assembly to drive the second sampling needle to move to the sampling position; and the third controller is configured to control the second needle to release the second set amount of sample when the eighth detector detects that the sample application site has the cuvette and the seventh detector detects that the second needle has moved to the sample application site.

In the sample adding system, the samples are cached through the sample caching and adding device, so that the first sample adding device sequentially absorbs the samples in each sample tube on the sample frame, each sample absorbed by the first sample adding device is cached by the sample caching and adding device, after each sample is cached on the sample frame, the sample frame can be taken off, a new sample frame can be taken on, the sample frame does not need to wait for the detection of the samples and the retest of the samples, the sample taking period is shortened, and the sample detection period is shortened. It can be understood that the sample loading system also shortens the rack unloading period of the sample.

Because the sample loading system shortens the loading period of the sample, the functional requirement of rapid sample turnover of the full-automatic sample processing system can be met. It can be understood that the sample adding system can meet the requirement that the in vitro diagnosis analyzer is connected to the full-automatic sample processing system, can enable the sample in the in vitro diagnosis analyzer to be quickly transmitted back to the full-automatic sample processing system, and achieves the requirement of quickly transmitting the sample.

In the sample adding system, if the detection result of the sample is abnormal, the second sample adding device can directly absorb the sample with the abnormal detection result in the sample caching and adding device and release the sample in the reaction cup at the adding position for retesting, so that the sample with the abnormal detection result is not required to be put on the shelf again, and the time required by retesting the sample is effectively shortened.

Based on the sample adding system, the invention also provides an in-vitro diagnosis analyzer which comprises the sample adding system.

Because above-mentioned sample application of sample system has above-mentioned technological effect, above-mentioned external diagnosis analysis appearance includes above-mentioned sample application of sample system, then above-mentioned external diagnosis analysis appearance also has corresponding technological effect, and this is no longer repeated here.

Optionally, the in vitro diagnostic analyzer further comprises a sample injection system, the sample injection system comprising a sample rack base for placing at least two sample racks distributed side by side.

Based on the sample adding system provided above, the invention also provides a sample adding method, the sample adding method is applied to an in vitro diagnosis analyzer, the sample adding method comprises:

sucking a sample for the first time from the sample sucking position;

moving the sample drawn for the first time to a cache bit and caching;

moving the sample of the cache bit to a cache sample bit;

second sucking the sample from the cache sample bit;

transferring the sample sucked for the second time to a sample adding position;

wherein the number of buffered samples is an integer multiple of the number of sample tubes on each sample rack.

Optionally, in the sample adding method, the first sample suction from the sample suction position specifically includes: sucking a first set amount of sample from a sample sucking position for the first time;

the second time of sucking the sample from the cache sampling bit specifically comprises: a second time a second set amount of the sample is drawn from the cache sample bits;

the first set quantity is not less than the sum of the quantity of the sample required for completing all detection items and the quantity of the sample required for retesting, and the second set quantity is the quantity of the sample required for completing a single detection item or the quantity of the sample required for retesting;

the number of the buffered samples is N, the time for buffering N-1 samples is not less than the time for completing all detection items and retesting of any one sample, N is a positive integer and is not less than 2.

Optionally, in the sample adding method, the first-time sample is buffered and moved to a buffer location, specifically:

moving the sample sucked for the first time to a buffer sample adding position;

moving the sample of the cache sample adding position to a position to be cached;

moving and caching the sample of the to-be-cached bit to the cache bit.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

FIG. 1 is a schematic diagram of the internal structure of an in vitro diagnostic analyzer according to an embodiment of the present invention;

fig. 2 is an exploded view of a first sample loading assembly in the sample loading system according to the embodiment of the present disclosure;

fig. 3 is an exploded view of a sample buffering and sample adding device in the sample adding system according to the embodiment of the present invention;

fig. 4 is an exploded view of a second sample loading device in the sample loading system according to the embodiment of the present invention;

FIG. 5 is a flowchart of a sample loading method according to an embodiment of the present invention;

fig. 6 is another flowchart of a sample loading method according to an embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

The in vitro diagnosis analyzer provided by the embodiment of the invention comprises: the device comprises a sample feeding system, a constant temperature system, a testing system, a cleaning system, a reaction cup selecting and conveying system, a mixing system, a code reading system, an operating software system and an auxiliary system; the operating software system and the auxiliary system may be referred to as computer systems, among others.

The type of the in vitro diagnostic analyzer is selected according to actual needs, for example, the in vitro diagnostic analyzer is a full-automatic coagulation analyzer, and the full-automatic coagulation analyzer can be a UR6000 full-automatic coagulation analyzer. Of course, the in vitro diagnostic analyzer may be other types of fully automatic coagulation analyzers or other types of analyzers, which is not limited in this embodiment.

As shown in fig. 1 and 2, the sample injection system includes a sample rack base 20, the sample rack base 20 is used for placing at least two sample racks 30 which are distributed side by side, and sample tubes are placed on the sample racks 30.

The number of sample racks 30 on the sample rack base 20 and the number of sample tubes that can be placed on the sample racks 30 are selected according to the actual situation. In some embodiments, there are ten sample holders 30, ten sample tubes can be placed in each sample holder 30, and each sample tube contains one sample, so that one hundred sample batches can be supported.

The sample rack base 20 has a sample rack site for placing a sample rack 30. The sample rack positions correspond to the sample racks 30 one to one. The distribution direction of any two sample holders is perpendicular to the length direction of the sample holders 30, i.e. the distribution direction of two adjacent sample holders 30 on the sample holder base 20 is perpendicular to the length direction of the sample holders 30.

In some embodiments, the sample introduction system may further include a sample introduction assembly that transports the sample rack 30 and moves the sample rack 30 onto the sample rack base 20.

In order to shorten the sample loading period, and thus shorten the period of batch detection of samples, and meet the requirement of rapid loading of samples, as shown in fig. 1 and fig. 2, the sample loading system includes: a first sample adding device 10, a second sample adding device 50 and a sample buffering sample adding device 40.

The first sample adding device 10 is used for sucking a sample from a sample tube at a sample sucking position, and the sample tube is disposed on the sample rack 30. It will be appreciated that the sample holder 30 is disposed on the sample holder base 20.

The sample buffering and sample adding device 40 is used for buffering samples absorbed by the first sample adding device 10, the sample buffering and sample adding device 40 can buffer N samples, N is an integral multiple of the number of sample tubes on each sample frame 30, and N is a positive integer. It can be understood that the sample buffering and loading device 40 can buffer N samples in the same time period. In some embodiments, N is less than the total number of samples that can be placed in the sample introduction system by the sample holder base 20. For example, the total number of samples that can be placed by the sample rack base 20 is one hundred and N is forty.

The second sample loading device 50 is used for sucking the sample from the sample buffering loading device 40 and releasing the sample in the reaction cup at the loading position.

In the sample adding system, the samples are cached through the sample caching and adding device 40, so that the samples in each sample tube on the sample frame 30 are sequentially absorbed by the first sample adding device 10, each sample absorbed by the first sample adding device 10 is cached by the sample caching and adding device 40, after each sample is cached on the sample frame 30, the sample frame 30 can be taken off, a new sample frame 30 can be taken on, the sample frame 30 does not need to wait for the detection of the samples and the retest of the samples, the sample taking period is shortened, and the sample detection period is shortened. It can be understood that the sample loading system described above also shortens the rack unloading period of the sample.

Because the sample loading system shortens the loading period of the sample, the functional requirement of rapid sample turnover of the full-automatic sample processing system can be met. It can be understood that the sample adding system can meet the requirement that the in vitro diagnosis analyzer is connected to the full-automatic sample processing system, can enable the sample in the in vitro diagnosis analyzer to be quickly transmitted back to the full-automatic sample processing system, and achieves the requirement of quickly transmitting the sample.

In some embodiments, the time required for retesting the sample is reduced based on the reduced sample loading period, and the first sample loading device 10 is used for sucking the first set amount of sample from the sample tube; the second sample adding device 50 is used for sucking a second set amount of sample from the sample caching and adding device 40; the first set quantity is not less than the sum of the quantity required by the sample to finish all detection items and the quantity required by the sample retest, and the second set quantity is the quantity required by the sample to finish a single detection item or the quantity required by the sample retest; the time for buffering N-1 samples by the sample buffering and sample adding device 40 is not less than the time for completing all detection items and retesting of any sample, and N is more than or equal to 2.

For example, the sample buffering and loading device 40 can buffer forty samples, and the time for buffering thirty-nine samples by the sample buffering and loading device 40 is longer than the time for completing all the detection items and retesting of any one sample. If the detection result of the sample is abnormal, the second sample adding device can directly absorb the sample with the abnormal detection result in the sample caching and adding device and release the sample in the reaction cup at the adding position for retesting, the sample with the abnormal detection result is not required to be put on the shelf again, and the time required by retesting the sample is effectively shortened.

The specific structure of the first sample adding device 10 is selected according to actual conditions. In some embodiments, the first sample application device 10 comprises: a sample container 11, a sample transport assembly 12, and a first sample application assembly 13; the sample caching and sampling device 40 comprises a sample caching disc 41 and a grabbing component; the first sample adding component 13 is used for sucking a first set amount of sample from a sample sucking position and releasing the first set amount of sample into the sample container 11 at a buffer sample adding position, and the sample conveying component 12 is used for conveying the sample container 11 between the buffer sample adding position and a position to be buffered; the sample buffer tray 41 is used for placing the sample containers 11, and the gripping assembly is used for moving the sample containers 11 to be buffered to the sample buffer tray 41 and for moving the sample containers 11 on the sample buffer tray 41.

The type of the sample container 11 is selected according to actual conditions, and this embodiment does not limit this.

The sample transfer assembly 12 may be a belt transfer assembly, a chain transfer assembly or other types of transfer assemblies, but this embodiment is not limited thereto.

The type of the first sample adding component 13 is selected according to actual conditions. In some embodiments, the first sample application assembly 13 comprises: a first sample adding needle 131, a first bracket 133, and a first sample adding needle moving component 132 arranged on the first bracket 133; wherein, the first sample adding needle 131 is used for sucking and releasing a sample; the first sample application needle movement component 132 drives the first sample application needle 131 to move back and forth between the sample suction position and the buffer sample application position. It can be understood that the first needle movement component 132 drives the first needle 131 to move from the sample suction position to the buffer sample position, and drives the first needle 131 to move from the buffer sample position to the sample suction position.

The specific structure of the first bracket 133 is selected according to practical situations, for example, the first bracket 133 is a gantry structure, which is not limited in this embodiment.

In order to facilitate the first sample application needle 131 to move back and forth between the sample suction position and the buffer sample application position, the first sample application needle movement assembly 132 drives the first sample application needle 131 to move in the X direction, the Y direction and the Z direction, wherein the X direction, the Y direction and the Z direction are perpendicular to each other, that is, the X direction is perpendicular to the Y direction, the X direction is perpendicular to the Z direction, and the Y direction is perpendicular to the Z direction.

The specific structure of the first loading needle moving component 132 is selected according to actual needs. In some embodiments, the first loading needle moving assembly 132 includes a first loading needle lifting assembly, a first loading needle Y-direction moving assembly, and a first loading needle X-direction moving assembly, where Z direction is a vertical direction, Y direction and X direction are both parallel to a horizontal plane, the first loading needle lifting assembly drives the first loading needle 131 to lift along the vertical direction (Z direction), the first loading needle lifting assembly is disposed on the first loading needle Y-direction moving assembly, the first loading needle Y-direction moving assembly drives the first loading needle lifting assembly to move back and forth along the Y direction, the first loading needle Y-direction moving assembly is disposed on the first loading needle X-direction moving assembly, the first loading needle X-direction moving assembly is disposed on the first support 133, and the first loading needle X-direction moving assembly drives the first loading needle Y-direction moving assembly to move back and forth along the X direction.

In other embodiments, the first loading needle moving assembly 132 can be selected to have other structures, and is not limited to the above embodiments.

In order to realize automatic control, the in vitro diagnostic analyzer further comprises: the detector comprises a first detector, a second detector, a third detector, a fourth detector and a first controller. The first detector is used for detecting whether a sample tube exists at a sample sucking position; the second detector is used for detecting whether the first sample adding needle 131 reaches the sample sucking position; the third detector is used for detecting whether the first sample adding needle 131 reaches the buffer sample adding position; the fourth detector is used for detecting whether the sample container 11 on the sample buffer disk 41 reaches the buffer sample adding position; under the condition that the first detector detects that the sample sucking position has a sample tube, the first controller is used for controlling the first sample adding needle moving assembly 132 to drive the first sample adding needle 131 to move to the sample sucking position; under the condition that the second detector detects that the first sample application needle 131 reaches the sample application position, the first controller is used for controlling the first sample application needle 131 to absorb a sample and controlling the first sample application needle movement assembly 132 to drive the first sample application needle 131 to move to the buffer sample application position; under the condition that the third detector detects that the first sample adding needle 131 reaches the buffer sample adding position and the fourth detector detects that the sample container 11 on the sample buffer disc 41 reaches the buffer sample adding position, the first controller is configured to control the first sample adding needle 131 to release the sample.

In other embodiments, the first sample adding device 10 can also comprise: a first sample application assembly 13; the sample caching and sampling device 40 comprises a sample caching disc 41 and a grabbing component; the sample buffer tray 41 is used for placing the sample container 11, the grasping assembly is used for moving the sample container 11 to the sample buffer tray 41 and for moving the sample container 11 on the sample buffer tray 41, and the first sample adding assembly 13 is used for sucking a first set amount of sample from a sample sucking position and releasing the first set amount of sample in the sample container 11 on the sample buffer tray 41.

In some embodiments, the sample buffer tray 41 is provided with placing holes for placing the sample containers 11, the placing holes being distributed in sequence along the circumferential direction of the sample buffer tray 41; the sample caching and sampling device 40 further comprises a cache disk horizontal movement assembly 43, wherein the cache disk horizontal movement assembly is used for driving the sample cache disk 41 to rotate in a horizontal plane so as to enable each placing hole to move to a cache position in sequence; the grabbing component is used for moving the sample container 11 to be cached to the placing hole of the caching position.

The specific structure of the buffer disk horizontal movement assembly 43 is selected according to practical situations, and this embodiment is not limited to this.

In some embodiments, the grasping assembly includes: hand grip 47 and hand grip motion assembly; wherein the gripper 47 is used for gripping and releasing the sample container 11, and the gripper motion assembly drives the gripper 47 to move back and forth between the buffer position to be buffered and the buffer position. It is understood that the gripper motion assembly drives the gripper 47 to move from the cache to the cache location and from the cache to the cache location; the gripper motion assembly is also used to drive the gripper 47 to remove a sample container from the sample buffer tray 41.

The specific structure and type of the hand grip 47 are selected according to actual situations, and this embodiment is not limited thereto.

The specific structure and type of the gripper motion assembly are selected according to actual conditions. In some embodiments, the gripper motion assembly comprises: a gripper horizontal movement assembly 44, a gripper lifting movement assembly 45, and a gripper telescoping movement assembly 46; the hand grip 47 is arranged on the hand grip telescopic motion assembly 46, and the hand grip telescopic motion assembly 46 is used for driving the hand grip 47 to move along the horizontal direction; the gripper telescopic motion assembly 46 is arranged on the gripper lifting motion assembly 45, and the gripper lifting motion assembly 45 is used for driving the gripper telescopic motion assembly 46 to lift; the gripper lifting motion assembly 45 is arranged on the gripper horizontal motion assembly 44, and the gripper horizontal motion assembly 44 is used for driving the gripper lifting motion assembly 45 to rotate in the horizontal plane.

In order to simplify the structure of the sample buffer loading device 40, the rotation axis of the hand grip lifting motion assembly 45 and the rotation axis of the sample buffer disk 41 are collinear. In some embodiments, the gripper horizontal motion assembly 44 comprises: the gripper rotation driving component drives a first driving wheel of the first belt transmission component to rotate, a first driven wheel of the first belt transmission component is in transmission connection with the first driving wheel through a first belt, and the gripper lifting motion component 45 is arranged on the first driven wheel; the buffer disk horizontal movement assembly 43 comprises a buffer disk rotation driving part and a second belt transmission assembly, the buffer disk rotation driving part drives a second driving wheel of the second belt transmission assembly to rotate, a second driven wheel of the second belt transmission assembly is in transmission connection with the second driving wheel through a second belt, and the sample buffer disk 41 is arranged on the second driven wheel; wherein the first driven wheel and the second driven wheel are coaxially arranged. It will be appreciated that the first driven pulley and the second driven pulley are distributed in this order in the axial direction of the first driven pulley, i.e., in the axial direction of the second driven pulley.

To facilitate the installation of the gripper lifting movement assembly 45, the gripper lifting movement assembly 45 is disposed on the first driven wheel through a mounting plate 48.

In some embodiments, the sample buffer loading device 40 further includes a buffer support 42, and the buffer tray horizontal moving assembly 43 and the hand grip horizontal moving assembly 44 are disposed on the buffer support 42. In order to reduce the volume of the sample buffer sample adding device 40, a first driven wheel and a second driven wheel can be selected to be positioned between the gripper rotation driving part and the rotating disc rotation driving part.

In some embodiments, in order to facilitate the sampling of the second sample loading device 50, the sample buffer loading device 50 has a buffer sampling position, and the buffer tray horizontal moving assembly 43 is further configured to drive the sample buffer tray 41 to rotate in the horizontal plane so that each placing hole moves to the buffer sampling position; the second sample loading device 50 is used for sucking the sample from the buffer sampling site.

The cache sample bit and the cache bit may be one location or may be different locations. In order to avoid interference between the grasping element and the second sample loading device 50, the buffer sampling position and the buffer position are two different positions. In this case, one of the placement holes may be selected to move to the cache bit, while the other placement hole may be selected to move to the cache sample bit.

In some embodiments, the second sample application device 50 comprises: a second sample application needle 51, a second bracket 54, and a second sample application needle movement component arranged on the second bracket 54; wherein, the second sample adding needle 51 is used for sucking and releasing the sample; the second sampling needle motion assembly is used for driving the second sampling needle 51 to reciprocate between the buffer sampling position and the sampling position.

In order to reduce the movement space required for the second sample application needle 51, the second sample application needle movement assembly comprises: a second sample application needle horizontal movement unit 53 and a second sample application needle elevation movement unit 55; the second sample adding needle horizontal movement component 53 is used for driving the second sample adding needle 51 to rotate in the horizontal plane; the second sample application needle horizontal movement component 53 is arranged on the second support 54 in a liftable manner, and the second sample application needle lifting movement component 55 is arranged on the second support 54 and is used for driving the second sample application needle horizontal movement component 53 to lift.

In order to facilitate the second sample application needle 51 to suck and release a sample, the second sample application needle 51 is arranged on the second sample application needle rotating shaft through the sample application arm 52, and the second sample application needle horizontal movement component 53 drives the second sample application needle rotating shaft to rotate in the horizontal plane, so that the second sample application needle 51 is driven to rotate in the horizontal plane by the second sample application needle horizontal movement component 53.

The second sample feeding needle horizontal moving component 53 can be a belt transmission mechanism, a chain transmission mechanism, etc., which is not limited in this embodiment.

The second sample application needle lifting/lowering movement assembly 55 can be a belt transmission mechanism, a chain transmission mechanism, or a lead screw transmission mechanism, which is not limited in this embodiment.

In some embodiments, to achieve automatic control, the sample loading system further includes: a fifth detector, a sixth detector, a seventh detector, an eighth detector, and a second controller and a third controller.

The fifth detector is configured to detect whether the sample container 11 on the sample buffer tray 41 reaches the buffer sampling position, the sixth detector is configured to detect whether the second sample injection needle 51 reaches the buffer sampling position, the seventh detector is configured to detect whether the second sample injection needle 51 reaches the sample injection position, and the eighth detector is configured to detect whether the sample injection position has a reaction cup.

In the case that the fourth detector does not detect that the sample container 11 on the sample buffer tray 41 reaches the buffer loading position, and the fifth detector does not detect that the sample container 11 on the sample buffer tray 41 reaches the buffer sampling position, the second controller is configured to control the buffer tray horizontal movement assembly 43 to drive the sample buffer tray 41 to rotate in the horizontal plane; under the condition that the fourth detector detects that the sample containers 11 on the sample buffer tray 41 reach the buffer sample adding positions, the second controller is configured to control the buffer tray horizontal movement assembly 43 to stop driving for a first preset time; in the case where the fifth detector detects that the sample container 11 on the sample buffer disk 41 reaches the buffer sampling position, the second controller is configured to control the buffer disk horizontal movement assembly 43 to stop driving for a second preset time period. The lengths of the first preset duration and the second preset duration are selected according to actual conditions, and this embodiment does not limit this.

Under the condition that the fifth detector detects that the sample containers 11 on the sample buffer disk 41 reach the buffer sampling position, the third controller is configured to control the second probe moving assembly to drive the second probe 51 to move to the buffer sampling position; when the sixth detector detects that the second sample application needle 51 reaches the cache sampling position, the third controller is configured to control the second sample application needle to absorb a second set amount of sample and to control the second sample application needle movement assembly to drive the second sample application needle 51 to move to the sample application position; the third controller is configured to control the second needle 51 to release the second set amount of sample when the eighth detector detects that the sample application site has a cuvette and the seventh detector detects that the second needle 51 is moved to the sample application site.

To facilitate the placement of the cable, the second sample application device 50 further includes a drag chain 46, and the drag chain 46 is configured to receive the cable. The cable is used for power supply and signal transmission. For example, the cable is connected to the power supply, the second sampling needle horizontal movement assembly 53 and the second sampling needle lifting movement assembly 55, so that the power supply supplies power to the second sampling needle horizontal movement assembly 53 and the second sampling needle lifting movement assembly 55; or the cable connects the controller and each sensor to ensure automatic control.

Because above-mentioned sample application of sample system has above-mentioned technological effect, above-mentioned external diagnosis analysis appearance includes above-mentioned sample application of sample system, then above-mentioned external diagnosis analysis appearance also has corresponding technological effect, and this paper is no longer repeated.

In the in vitro diagnosis analyzer, the specific structure of the constant temperature system is selected according to the actual situation. For example, the thermostatic system includes a thermostatic base shown in fig. 1, the thermostatic base has a thermostatic placing hole for placing a reaction cup, and the thermostatic system further includes a heating assembly for heating the reaction cup, which is not limited in this embodiment.

In the in vitro diagnosis analyzer, the specific structure of the constant temperature system is selected according to the actual situation. For example, the testing system includes a first testing component 60 and a second testing component 90 as shown in FIG. 1, the first testing component 60 is used for completing the detection of a first detection item, and the second testing component 90 is used for completing the detection of a second detection item; wherein, the first testing component 60 and the second testing component 90 are relatively independent and do not influence each other.

In the in vitro diagnosis analyzer, the specific structure of the reaction cup selection and transmission system is selected according to the actual situation. For example, the cuvette picking and transfer system includes a cuvette picking and loading assembly 70 as shown in FIG. 1. The cuvette picking and loading assembly 70 is used to complete the picking of cuvettes and loading of corresponding samples.

In the in vitro diagnostic analyzer, the specific structures of the washing system, the blending system, the code reading system, the operating software system and the auxiliary system are selected according to actual conditions, and the embodiment does not limit the specific structures.

Based on the sample loading system provided in the above embodiment, an embodiment of the present application further provides a sample loading method, as shown in fig. 5, the sample loading method includes:

s11: the sample is aspirated for the first time from the aspiration site.

It will be appreciated that the sample aspirating position is the position opposite to the sample tube on the sample rack, which is disposed at the base of the sample rack. The specific suction manner in the above step is selected according to actual conditions, and this embodiment does not limit this.

S12: the first sample drawn is moved to a cache bit and cached.

The number of buffered samples is an integer multiple of the number of sample tubes per sample rack 30. For example, if the number of sample tubes on one sample rack 30 is ten, the number of samples that can be buffered is ten, twenty, thirty, or one hundred, and the like, which is not limited in this embodiment.

In the above steps, the moving mode and the moving path of the sample are selected according to actual situations, which are not limited in this embodiment.

S13: the sample of the cache bit is moved to the cache sample bit.

In the above steps, the moving mode and the moving path of the sample are selected according to actual situations, which are not limited in this embodiment.

S14: the second sample is drawn from the buffered sample bits.

The specific suction manner in the above step is selected according to the actual situation, and this embodiment does not limit this.

S15: and moving the sample sucked for the second time to the sample adding position.

In the above steps, the moving mode and the moving path of the sample are selected according to actual conditions, which is not limited in this embodiment.

In the sample adding method, each sample sucked for the first time is cached, and after each sample is cached on the sample rack, the sample rack can be taken off the rack, and a new sample rack can be taken on the rack, so that the sample rack does not need to wait for the detection of the sample and the retesting of the sample, the sample taking period is shortened, and the sample detection period is shortened. It can be understood that the sample loading method described above also shortens the rack unloading period of the sample.

Due to the fact that the sample loading method shortens the loading period of the sample, the functional requirement of rapid sample turnover of the full-automatic sample processing system can be met. It can be understood that the sample adding method can meet the requirement that the in vitro diagnostic analyzer is connected to the full-automatic sample processing system, can quickly convey the sample in the in vitro diagnostic analyzer back to the full-automatic sample processing system, and meets the requirement of quickly conveying the sample.

In order to shorten the sample retest time, the step S11 is specifically: sucking a first set amount of sample from a sample sucking position for the first time; the S14 is specifically: sucking a second set amount of samples from the cache sampling bits for a second time; the first set quantity is not less than the sum of the quantity of the sample required for completing all detection items and the quantity of the sample required for retesting, and the second set quantity is the quantity of the sample required for completing a single detection item or the quantity of the sample required for retesting; the number of the buffered samples is N, the time for buffering N-1 samples is not less than the time for completing all detection items and retesting of any sample, N is a positive integer and is more than or equal to 2. Therefore, if the detection result of the sample is abnormal, the sample with the abnormal detection result can be directly sucked at the cache sampling position and released in the reaction cup at the sample adding position for retest, the sample with the abnormal detection result is not required to be put on a shelf again, and the time required by retest of the sample is effectively shortened.

In order to facilitate buffering the sample that is first drawn and moving the sample to the buffer bit, S12 is specifically: transferring the sample sucked for the first time to a buffer sample adding position; moving the sample of the buffered sample adding position to a position to be buffered; and moving the sample of the bit to be cached to the cache bit and caching.

In some embodiments, in order to shorten the sample retest time and facilitate the first sample drawn to be buffered and moved to a buffer location, as shown in fig. 6, the sample loading method includes:

s21: a first set amount of sample is aspirated from the sample aspirating position for a first time.

S22: and moving the sample sucked for the first time to a buffer sample adding position.

S23: and moving the sample of the buffered sample adding position to a position to be buffered.

S24: the samples of the bits to be cached are moved to the cache bits and cached.

S25: the samples of the cache bits are moved to the cache sample bits.

S26: the second sample is drawn from the cache sample bit.

S27: and moving the sample sucked for the second time to a sample adding position.

The above steps can refer to the above description, and are not repeated herein.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (18)

1. A sample application system for an in vitro diagnostic analyzer, the sample application system comprising: the sample buffer device comprises a first sample adding device, a second sample adding device and a sample buffer adding device;

the first sample adding device is used for sucking a sample from a sample tube at a sample sucking position, and the sample tube is arranged on a sample rack;

the sample caching and sample adding device is used for caching the sample absorbed by the first sample adding device;

the second sample loading device is used for sucking the sample from the sample caching and loading device and releasing the sample into a reaction cup at a loading position;

the sample caching and sampling device can cache N samples, N is an integral multiple of the number of the sample tubes on each sample rack, and N is a positive integer.

2. Sample application system according to claim 1,

the first sample adding device is used for sucking a first set amount of sample from the sample tube;

the second sample loading device is used for sucking a second set amount of the sample from the sample caching loading device;

the first set quantity is not less than the sum of the quantity required by the sample to finish all detection items and the quantity required by the sample retest, and the second set quantity is the quantity required by the sample to finish a single detection item or the quantity required by the sample retest;

the time for buffering N-1 samples by the sample buffering and sample adding device is not less than the time for finishing all detection items and retesting of any one sample, and N is more than or equal to 2.

3. Sample application system according to claim 1 or 2,

the first sample adding device comprises: a sample container, a sample transport assembly, and a first sample application assembly;

the sample caching and sample adding device comprises a sample caching disc and a grabbing component;

the first sample loading component is used for sucking the first set amount of sample from a sample sucking position and releasing the first set amount of sample into the sample container at a buffer loading position, and the sample conveying component is used for conveying the sample container between the buffer loading position and a position to be buffered;

the sample buffer disk is used for placing the sample containers, and the grabbing component is used for moving the sample containers of the to-be-buffered positions to the sample buffer disk and moving the sample containers on the sample buffer disk out.

4. The sample loading system of claim 3, wherein the first sample loading assembly comprises: the device comprises a first sample adding needle, a first bracket and a first sample adding needle movement component arranged on the first bracket;

wherein the first sample adding needle is used for sucking and releasing the sample;

and the first sample adding needle motion assembly drives the first sample adding needle to reciprocate between the sample sucking position and the buffer sample adding position.

5. The sample loading system according to claim 4, further comprising:

the first detector is used for detecting whether the sample sucking position has the sample tube or not;

the second detector is used for detecting whether the first sample adding needle reaches the sample sucking position;

a third detector, configured to detect whether the first sample application needle reaches the buffer sample application position;

a fourth detector for detecting whether the sample container reaches the buffer loading position;

the first controller is used for controlling the first sample adding needle motion assembly to drive the first sample adding needle to move to the sample sucking position under the condition that the first detector detects that the sample sucking position has the sample tube; when the second detector detects that the first sample application needle reaches the sample suction position, the first controller is used for controlling the first sample application needle to suck the sample and controlling the first sample application needle movement assembly to drive the first sample application needle to move to the cache sample application position; the first controller is configured to control the first sample application needle to release the sample when the third detector detects that the first sample application needle reaches the buffer sample application position and the fourth detector detects that the sample container reaches the buffer sample application position.

6. Sample application system according to claim 3,

the sample buffer disk is provided with placing holes for placing the sample containers, and the placing holes are distributed along the circumferential direction of the sample buffer disk in sequence;

the sample caching and sample adding device further comprises a caching disc horizontal moving assembly, and the caching disc horizontal moving assembly is used for driving the sample caching disc to rotate in a horizontal plane so as to enable each placing hole to move to a caching position in sequence;

the grabbing component is used for moving the sample container to be cached to the placing hole in the caching position.

7. The sample loading system of claim 6, wherein the grasping assembly comprises:

a grip for gripping and releasing the sample container;

and the gripper moving assembly drives the gripper to move back and forth between the position to be cached and the caching position.

8. The sample loading system of claim 7, wherein the grip motion assembly comprises: the gripper horizontal movement assembly, the gripper lifting movement assembly and the gripper telescopic movement assembly are arranged on the gripper horizontal movement assembly;

the gripper is arranged on the gripper telescopic motion assembly, and the gripper telescopic motion assembly is used for driving the gripper to move along the horizontal direction;

the hand grip telescopic motion assembly is arranged on the hand grip lifting motion assembly, and the hand grip lifting motion assembly is used for driving the hand grip telescopic motion assembly to lift;

the gripper lifting motion assembly is arranged on the gripper horizontal motion assembly, and the gripper horizontal motion assembly is used for driving the gripper lifting motion assembly to rotate in the horizontal plane.

9. The sample application system of claim 8, wherein the rotation axis of the gripper lift motion assembly and the rotation axis of the sample buffer tray are collinear.

10. The sample loading system according to claim 6, wherein the sample buffer loading device has a buffer sampling position, and the buffer tray horizontal movement assembly is further configured to drive the sample buffer tray to rotate in a horizontal plane so that each placement hole is sequentially moved to the buffer sampling position; the second sample adding device is used for sucking the sample from the cache sampling position.

11. The sample loading system of claim 10, wherein the second sample loading device comprises: the second sample adding needle, the second bracket and a second sample adding needle moving component are arranged on the second bracket;

wherein the second sample adding needle is used for sucking and releasing the sample;

and the second sample adding needle motion assembly is used for driving the second sample adding needle to reciprocate between the buffer sampling position and the sample adding position.

12. The sample loading system of claim 11, wherein the second loading needle movement assembly comprises: the second sample adding needle horizontal movement assembly and the second sample adding needle lifting movement assembly;

the second sample adding needle horizontal movement assembly is used for driving the second sample adding needle to rotate in a horizontal plane;

the second sample adding needle horizontal moving assembly is arranged on the second support in a liftable mode, and the second sample adding needle lifting moving assembly is arranged on the second support and used for driving the second sample adding needle horizontal moving assembly to lift.

13. The sample loading system according to claim 11, further comprising:

a fifth detector for detecting whether the sample container on the sample cache disk reaches the cache sample bit;

a sixth detector, configured to detect whether the second sampling needle reaches the cache sampling location;

a seventh detector for detecting whether the second sample application needle reaches the sample application position;

an eighth detector for detecting whether the sample addition site has a reaction cup;

a second controller for controlling the buffer tray horizontal motion assembly to drive the sample buffer tray to rotate in a horizontal plane if the fourth detector does not detect that the sample containers on the sample buffer tray reach the buffer loading position and the fifth detector does not detect that the sample containers on the sample buffer tray reach the buffer sampling position; when the fourth detector detects that the sample container on the sample cache disk reaches the cache loading position, the second controller is used for controlling the cache disk horizontal movement assembly to stop driving for a first preset time; the second controller is used for controlling the buffer disk horizontal motion assembly to stop driving for a second preset time when the fifth detector detects that the sample container on the sample buffer disk reaches the buffer sampling position;

a third controller, configured to control the second sampling needle moving component to drive the second sampling needle to move to the buffer sampling position when the fifth detector detects that the sample container on the sample buffer tray reaches the buffer sampling position; when the sixth detector detects that the second sample needle reaches the cache sampling position, the third controller is configured to control the second sample needle to suck the second set amount of sample and to control the second sample needle moving assembly to drive the second sample needle to move to the sample position; and the third controller is used for controlling the second sample adding needle to release the second set amount of sample under the condition that the eighth detector detects that the sample adding position is provided with the reaction cup and the seventh detector detects that the second sample adding needle moves to the sample adding position.

14. An in vitro diagnostic analyzer comprising a sample application system according to any one of claims 1 to 13.

15. The sample application system of claim 14, further comprising a sample application system comprising a sample rack base for receiving at least two sample racks arranged side-by-side.

16. A sample adding method is applied to an in-vitro diagnosis analyzer and is characterized by comprising the following steps:

sucking a sample for the first time from a sample sucking position;

moving and caching the sample drawn for the first time to a cache bit;

moving the sample of the cache bit to a cache sample bit;

second sucking the sample from the cache sample bit;

moving the sample sucked for the second time to a sample adding position;

wherein the number of buffered samples is an integer multiple of the number of sample tubes on each sample rack.

17. The method for applying a sample according to claim 16,

the sample is sucked for the first time from the sample sucking position, and the method specifically comprises the following steps: sucking a first set amount of sample from a sample sucking position for the first time;

the second time of sucking the sample from the cache sampling bit specifically comprises: a second time a second set amount of the sample is drawn from the cache sample bits;

the first set quantity is not less than the sum of the quantity required by the sample to finish all detection items and the quantity required by the sample retest, and the second set quantity is the quantity required by the sample to finish a single detection item or the quantity required by the sample retest;

the number of the buffered samples is N, the time for buffering N-1 samples is not less than the time for completing all detection items and retesting of any one sample, N is a positive integer and is more than or equal to 2.

18. A sample loading method according to claim 16, wherein the sample drawn for the first time is buffered and moved to a buffer location, specifically:

moving the sample sucked for the first time to a buffer sample adding position;

moving the sample of the cache sample adding position to a position to be cached;

moving and caching the sample of the to-be-cached bit to the cache bit.

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