CN115919584B

CN115919584B - Bionic uterine system

Info

Publication number: CN115919584B
Application number: CN202310024865.0A
Authority: CN
Inventors: 马立霜; 祝刚; 王莹; 刘超; 魏延栋; 李景娜; 王红梅
Original assignee: AFFILIATED CHILDREN'S HOSPITAL OF CAPITAL INSTITUTE OF PEDIATRICS
Current assignee: AFFILIATED CHILDREN'S HOSPITAL OF CAPITAL INSTITUTE OF PEDIATRICS
Priority date: 2023-01-09
Filing date: 2023-01-09
Publication date: 2023-05-26
Anticipated expiration: 2043-01-09
Also published as: CN115919584A

Abstract

The invention relates to a bionic uterine system, which comprises a biological bag, a microfluidic oxygenator arteriovenous circuit, an amniotic fluid input structure and a leak-proof structure; the micro-fluidic oxygenator arteriovenous loop is detachably connected with the biological bag, and the amniotic fluid input structure is detachably connected with the biological bag; the liquid leakage preventing structure comprises a first leakage preventing structure and a second leakage preventing structure, the first leakage preventing structure is fixedly connected with the biological bag, the second leakage preventing structure is arranged on the first leakage preventing structure, and the second leakage preventing structure is detachably connected with the first leakage preventing structure; through setting up leak protection liquid structure, guaranteed when the fetal bronchoscope passes biological bag through the trocar and gets into the fetal air flue, the phenomenon of weeping can not appear in the biological bag, can not cause the infection in the biological bag.

Description

Bionic uterine system

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a bionic uterine system.

Background

Premature infants refer to neonates with gestational age less than 37 weeks (premature infants are classified according to the differences of gestational ages, extremely premature infants refer to premature infants with gestational age less than 28 weeks, and early premature infants refer to premature infants with gestational age between 28 weeks and 32 weeks, and advanced premature infants with gestational age between 32 and 37 weeks). Premature infants are susceptible to various system dysplasia (respiratory distress syndrome, apnea and bronchopulmonary dysplasia are easily caused by the immature respiratory system development, hypotension and arterial catheter opening are easily caused by the circulatory system, feeding intolerance and necrotizing enterocolitis are easily caused by the digestive system, intracranial hemorrhage, brain dysplasia and the like are easily caused by the nervous system, and hypothermia, anemia, infection and the like are also possibly caused by the nervous system), so hospitalization is required.

In order to ensure the survival rate of premature infants, the prior art prevents the premature infants from completing post-natal treatment work in the incubator, but the in-process needs to be detected and assisted by a plurality of instruments, so that medical staff experience is very consumed, and the premature infants are greatly damaged by slight carelessness, and the existing incubator has the following defects: 1. adverse effects on heart lung and skin development (respiratory pattern, changes in surrounding environment); 2. the skin of the newborn is damaged due to the reasons of body position, easy sweating due to damp-heat and the like, and symptoms such as eczema dermatitis and the like appear; 3. can not absorb the parent nutrient through amniotic fluid, has low immunity and the like. And has no defect of obviously improving the survival rate of premature infants with gestational age less than 28 weeks and weight less than 1000 g.

With the advent of biological bags, in ethical scope, the placement of the born premature infant into a bionic uterine biological bag is also a way to rescue the newborn infant in the future. Prior art incubation systems such as 202080026003.6 for liquid-based incubation of premature infants; the method solves the technical problem of how to effectively configure the direction of the liquid incubation system and how to effectively simulate the uterus environment. When the premature infant enters the biological bag for treatment, when the fetus is in the biological bag, the liquid secreted by the lung can be discharged in the air passage of the fetus, and the lung can stop developing after the liquid is discharged, so that a balloon is required to be arranged in the air passage of the fetus to prevent the liquid from flowing out, which can cause the liquid to accumulate in the lung of the unborn fetus, and the pressure from the liquid can cause the lung to grow; there is therefore a need for a balloon to be placed in a biological bag in a premature infant to address the problem of dysplasia in the lungs of the premature infant, but the prior art fails to place a balloon and ensures that leakage of fluid in the biological bag does not occur.

The present invention addresses the above-described problems by providing a biomimetic uterine system.

Disclosure of Invention

In order to overcome the problems in the background art, the invention adopts the following technical scheme:

a bionic uterine system, which comprises a biological bag, an oxygenator arteriovenous loop, an amniotic fluid input structure and a leak-proof structure; the oxygenator arteriovenous loop is detachably connected with the biological bag, and the amniotic fluid input structure is detachably connected with the biological bag; the liquid leakage preventing structure comprises a first leakage preventing structure and a second leakage preventing structure, the first leakage preventing structure is fixedly connected with the biological bag, the second leakage preventing structure is arranged on the first leakage preventing structure, and the second leakage preventing structure is detachably connected with the first leakage preventing structure; through setting up leak protection liquid structure, guaranteed when the fetal bronchoscope passes biological bag through the trocar and gets into the fetal air flue, the phenomenon of weeping can not appear in the biological bag, can not cause the infection in the biological bag.

Further, a double-track self-sealing opening is arranged on the biological bag, and a fetus can be placed in the double-track self-sealing opening and then sealed.

Further, a liquid inlet is formed in the first end of the biological bag, and a liquid outlet is formed in the second end of the biological bag; after the fetus is placed in the biological bag, the head is placed in the liquid outlet, and the tail is placed in the liquid inlet.

Further, a surgical instrument placing hole is arranged at any position on one side of the liquid outlet of the biological bag, and the diameter of the surgical instrument placing hole is larger than that of the saccule, so that the saccule can be easily introduced.

Further, the oxygenator arteriovenous loop comprises an oxygenator, a drug/nutrient injection pump, a pressure sensor, a flow sensor, a gas mixing device, an oxygen/carbon dioxide gas sensor and a heat exchanger; the biological bag is connected with the oxygenator through three pipelines, two pipelines are connected with an umbilical artery, one pipeline is connected with an umbilical vein, a medicine/nutrient injection pump and a pressure sensor are arranged on the umbilical artery pipeline and then connected with the oxygenator, and the oxygenator is also connected with a flow sensor, a gas mixing device and an oxygen/carbon dioxide gas sensor to realize oxygen supply and carbon dioxide discharge of a living body; the umbilical vein pipeline is provided with a pressure sensor, a heart rate blood oxygen sensor, a flow sensor and a heat exchanger to realize the supply of vital oxygen and nutrition and the long-term life development support.

Further, the amniotic fluid input structure comprises a peristaltic pump, a flow sensor and a filter; peristaltic pump, flow sensor and filter pass through pipeline fixed connection, and filter rear end pipeline connection is on the liquid inlet of biological bag first end.

Further, the first leak protection structure includes stationary blade, first cylinder piece and baffle, the stationary blade is for dismantling with first cylinder piece and be connected, the baffle sets up on first cylinder piece, baffle and first cylinder piece swing joint, and above-mentioned setting has guaranteed that first cylinder piece can be dismantled from the stationary blade.

Further, the fixing piece is of any shape, a first round hole is formed in the middle of the fixing piece, the diameter of the round hole is larger than that of the surgical instrument placing hole, and the saccule can be placed in the biological bag easily.

Further, the fixing piece is provided with viscose, and can be directly adhered to the biological bag.

Further, the first side of the first cylindrical block is provided with a first groove, the first groove is circular, and the diameter of the first groove is smaller than that of the first round hole.

Further, a second groove is formed in the upper portion of the first groove of the first cylindrical block, the second groove is rectangular in shape, the length of the second groove is smaller than the diameter of the first groove, and the depth of the second groove is the same as that of the first groove.

Further, the second round holes are respectively formed in two sides of the second groove, and the baffle can be arranged in the second round holes and can move along the second round holes.

Further, a third round hole is formed in the middle of the first cylindrical block, the third round hole is a through hole, and the diameter of the third round hole is smaller than that of the first groove.

Further, the second side of the first cylindrical block is provided with a third groove, the diameter of the third groove is larger than that of the third round hole, and the balloon is guaranteed to be placed between the third groove and the second leakage-proof structure through the arrangement.

Further, threads are arranged on the outer side of the first cylindrical block.

Further, the baffle main part is the plectane, plectane diameter is greater than the third round hole, plectane upper portion sets up the rectangular plate, rectangular plate thickness is the same with the thickness of plectane, rectangular plate top center sets up the fourth recess, set up a connecting rod in the fourth recess.

Further, the both sides of rectangular plate set up the cylinder pole respectively, cylinder pole diameter is the same with the second round hole diameter, and cylinder pole mountable is inside the second round hole, and then the separation blade can rotate round the second round hole.

Further, a torsion spring is arranged on the connecting rod, the first end of the torsion spring is pressed on the baffle plate, the second end of the torsion spring is pressed on the first cylindrical block, the baffle plate and the first cylindrical block are pressed tightly by the torsion spring, and the baffle plate is pressed on the third round hole of the first cylindrical block.

Further, a sealing gasket is arranged on one side, in contact with the first cylindrical block, of the baffle plate, the sealing gasket is made of soft materials, and rubber materials are optionally used for the sealing gasket.

Further, the second leakage-proof structure comprises a second cylindrical block, a round rod and a leakage-proof block; the first end of the round rod is fixedly connected with the second cylindrical block, and the second end of the round rod is fixedly connected with the leakage-proof block.

Further, the bottom of the second cylindrical block is provided with a fourth groove, threads matched with the threads on the outer side of the first cylindrical block are arranged in the fourth groove, and the second cylindrical block can be fixed on the first cylindrical block through threaded connection.

Further, a channel for a bronchoscope (trocar) to enter is arranged inside the round rod.

Further, the leak protection piece is cylindrical, and the top sets up the fifth recess, a fifth recess internal fixation leak protection piece, set up the cross opening in the middle of the leak protection piece, can block the liquid outflow and can stretch into bronchoscope (trocar).

Further, the leakage-proof block is made of soft materials.

When the disposable baby-carrier is used, the second leakage-proof structure is unscrewed on the first leakage-proof structure, the balloon is connected to the bronchoscope, the rear end of the bronchoscope penetrates through the second leakage-proof structure, the balloon is arranged between the first leakage-proof structure and the first leakage-proof structure, the second leakage-proof structure is connected to the first leakage-proof structure, the bronchoscope at the rear end is pushed, the balloon can enter the biological bag through the first leakage-proof structure, the disposable baby-carrier can be suitable for airbags with different sizes, the disposable baby-carrier can be selected according to the conditions of a fetus, and other instruments such as a laparoscope can be used.

The invention has the beneficial effects that: the invention has reasonable structure; firstly, creating a living body amniotic fluid environment by a basic biological bag, and controlling the amniotic fluid flow, pressure and temperature; secondly, based on the principle of membrane lung oxygenation, a novel high-efficiency low-resistance oxygenator is developed by utilizing a chip technology, and oxygen supply and carbon dioxide discharge of a living body are realized; then, an extracorporeal arterial and venous pipeline without pump driving is built by taking a membrane pulmonary oxygenator as a core, and a nutrient solution supply loop is reserved, so that the supply of vital oxygen and nutrition is realized, and the long-term life development support is realized; by arranging the liquid leakage preventing structure, liquid leakage can not occur when the sacculus is arranged in the biological bag.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic cross-sectional view of the balloon of the present invention between a first leak-proof structure and a second leak-proof structure;

FIG. 3 is a schematic cross-sectional view of the balloon of the present invention through a leak-proof structure;

FIG. 4 is a schematic structural view of a fixing plate according to the present invention;

FIG. 5 is a schematic view of a first leak-proof structure according to the present invention;

FIG. 6 is a schematic view of the structure of the first side of the first cylindrical block of the present invention;

FIG. 7 is a schematic view of the structure of the second side of the first cylindrical block of the present invention;

FIG. 8 is a schematic view of the structure of the baffle plate of the present invention;

FIG. 9 is a schematic view of the structure of a second cylindrical block according to the present invention;

FIG. 10 is a schematic view of the structure of the leakage preventing sheet of the present invention;

FIG. 11 is a schematic cross-sectional view of a second cylindrical block of the present invention;

in the figure, 1, a biological bag; 2. an oxygenator; 3. a double track self-sealing opening; 4. a liquid inlet; 5. a liquid outlet; 6. a surgical instrument insertion hole; 7. a peristaltic pump; 8. a flow sensor; 9. a filter; 10. a fixing piece; 11. a first cylindrical block; 12. a baffle; 13. a first round hole; 14. a second round hole; 15. a torsion spring; 17. a connecting rod; 18. a cylindrical rod; 19. a sealing gasket; 20. a second cylindrical block; 21. a round bar; 22. a leakage preventing block; 23. a leakage preventing sheet; 24. bronchoscopes; 25. a balloon.

Detailed Description

The following detailed description of the embodiments of the present invention will be made more apparent to those skilled in the art from the following detailed description, in which the invention is embodied in several, but not all, embodiments of the invention. The invention may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the invention.

Example 1

Referring to fig. 1 to 11, a bionic uterine system according to the present embodiment includes a biological bag 1, an oxygenator arteriovenous loop, and an amniotic fluid input structure; the biological bag 1 is provided with a leak-proof entering instrument which can lead the balloon 25 to guide the structure to enter and is leak-proof;

the leak-proof access device is arranged in the area of the biological bag 1 corresponding to the premature infant head.

The leak-proof entering instrument is an instrument provided with a guide channel for realizing the entrance of the guide structure of the balloon 25 and a leak-proof one-way valve.

Alternatively, the leak-proof access apparatus comprises a first leak-proof structure and a second leak-proof structure; the first leakage-proof structure and the second leakage-proof structure are combined and arranged on the biological bag 1; the first leakage-proof structure and the second leakage-proof structure are provided with a guide channel for realizing the entrance of the guide structure of the balloon 25, and the biological bag 1 is provided with a surgical instrument insertion hole 6 for ensuring the entrance of the guide structure of the balloon 25. Through setting up the double-deck leak protection liquid structure's setting has guaranteed when the fetus bronchoscope 24 passes biological bag 1 through the trocar and gets into the fetus air flue, the phenomenon of weeping can not appear in biological bag 1, can not cause biological bag 1 internal infection.

Example 2

Referring to fig. 2-3,5-8, on the basis of embodiment 1, the following technical features are added in this embodiment: (the following specific settings are made for the first leak-proof structure): the first leakage-proof structure is fixedly connected with the biological bag 1, and the second leakage-proof structure is arranged on the first leakage-proof structure.

The diameter of the surgical instrument insertion hole 6 is larger than that of the guide structure of the balloon 25, so that the balloon 25 can be easily inserted.

The first leakage-proof structure and the second leakage-proof structure are combined in a sealed combination mode.

The first leakage-proof structure and the second leakage-proof structure are combined through corresponding thread structures or are combined through a sleeving and gluing mode.

The first leakage-proof structure comprises a first cylindrical block 11 and a baffle 12, wherein the baffle 12 is arranged on the first cylindrical block 11, the baffle 12 is movably connected with the first cylindrical block 11, and the arrangement ensures that the first cylindrical block 11 can be detached from the fixing piece 10; the guiding of the structure into the biological bag 1 by the balloon 25 is achieved by means of the inward opening of the baffles 12.

The first cylindrical block 11 is provided on a first side with a first recess, which is circular, the diameter of which is smaller than the diameter of the first circular hole 13.

The upper part of the first groove of the first cylindrical block 11 is provided with a second groove, the shape of the second groove is rectangular, the length of the second groove is smaller than the diameter of the first groove, and the depth of the second groove is the same as that of the first groove. The above arrangement allows the baffle 12 to be mounted in the first recess and the second recess.

The two sides of the second groove are respectively provided with a second round hole 14, and the arrangement ensures that the baffle 12 can be arranged in the second round hole 14, and the baffle 12 moves along the second round hole 14.

A third round hole is formed in the middle of the first cylindrical block 11, the third round hole is a through hole, and the diameter of the third round hole is smaller than that of the first groove.

The second side of the first cylindrical block 11 is provided with a third recess having a diameter larger than the third circular hole, which ensures that the balloon 25 can be placed between the third recess and the second leakage preventing structure.

Threads are provided on the outside of the first cylindrical block 11.

The baffle 12 main part is the plectane, and the plectane diameter is greater than the third round hole, and the plectane upper portion sets up the rectangular plate, and rectangular plate thickness is the same with the thickness of plectane, and rectangular plate top center sets up the fourth recess, sets up a connecting rod 17 in the fourth recess.

The cylinder pole 18 is set up respectively to the both sides of rectangular plate, and cylinder pole 18 diameter is the same with second round hole 14 diameter, and cylinder pole 18 can install inside second round hole 14, and then the separation blade can rotate round second round hole 14.

The connecting rod 17 is provided with a torsion spring 15, a first end of the torsion spring 15 is pressed on the baffle plate, a second end of the torsion spring 15 is pressed on the first cylindrical block 11, the torsion spring 15 presses the baffle plate 12 and the first cylindrical block 11, and the baffle plate 12 is pressed on a third round hole of the first cylindrical block 11.

A sealing gasket 19 is arranged on one side of the baffle 12, which is in contact with the first cylindrical block 11, the sealing gasket 19 is made of soft materials, and the sealing gasket 19 is made of rubber materials optionally.

The bottom of the first leakage-proof structure is provided with a fixing piece 10, and the fixing piece 10 is fixed on the biological bag 1.

The fixing piece 10 is of any shape, the first round hole 13 is formed in the middle of the fixing piece 10, and the diameter of the round hole is larger than that of the surgical instrument placing hole 6, so that the saccule 25 can be placed into the biological bag 1 easily.

The fixing piece 10 is provided with viscose, and the fixing piece 10 can be directly adhered to the biological bag 1; the fixing piece 10 is detachably connected with the first cylindrical block 11, and a first round hole 13 on the fixing piece 10 corresponds to a third round hole of the first cylindrical block 11.

Example 3

Referring to fig. 2-3,9-11, on the basis of embodiments 1-2, the following technical features (the following specific arrangement is performed on the second leakage preventing structure) are added: the second leakage preventing structure comprises a second cylindrical block 20, a round rod 21 and a leakage preventing block 22; the first end of the round rod 21 is fixedly connected with the second cylindrical block 20, and the second end of the round rod 21 is fixedly connected with the leakage-proof block 22.

The bottom of the second cylindrical block 20 is provided with a fourth groove, threads matched with the threads on the outer side of the first cylindrical block 11 are arranged in the fourth groove, and the second cylindrical block 20 can be fixed on the first cylindrical block 11 through threaded connection.

The round rod 21 is internally provided with a passage for the entry of a bronchoscope 24 (trocar).

The leakage-proof block 22 is cylindrical, a fifth groove is arranged at the top, a leakage-proof sheet 23 is fixed in the fifth groove, a cross opening is arranged in the middle of the leakage-proof sheet 23, and the leakage-proof block can block the outflow of liquid and can extend into a bronchoscope 24 (trocar).

The leakage preventing block 22 is a soft material.

Or, a laparoscope implantation hole is arranged in the middle of the biological bag 1, the diameter of the laparoscope implantation hole is larger than that of the laparoscope, so that the laparoscope can be easily accessed, and the method is suitable for a plurality of fetuses with malignant tumors growing in the chest cavity.

Or, a thermal gel injection hole is arranged at any position on the liquid inlet 4 side of the biological bag 1, the diameter of the thermal gel injection hole is larger than that of the laparoscope, so that the laparoscope can be easily accessed, and the device is suitable for a plurality of fetuses with malignant tumors in chest cavities.

When the disposable baby bag is used, the second leakage-proof structure is unscrewed on the first leakage-proof structure, the balloon 25 is connected to the bronchoscope 24, the rear end of the bronchoscope 24 passes through the second leakage-proof structure, the balloon 25 is arranged between the first leakage-proof structure and the first leakage-proof structure, the second leakage-proof structure is connected to the first leakage-proof structure, the bronchoscope 24 at the rear end is pushed, the balloon 25 can enter the biological bag 1 through the first leakage-proof structure, the disposable baby bag can be suitable for airbags with different sizes, and the disposable baby bag can be used by other instruments such as laparoscopes. The device can be used for placing not only the balloon 25 but also other surgical instruments.

Example 4

Referring to fig. 1, on the basis of embodiments 1-3, the following technical features (the following specific arrangements are performed on the biological bag 1 and other structures connected to the biological bag 1) are added:

the biological bag 1 is provided with a double-track self-sealing opening 3, and a fetus can be placed in the double-track self-sealing opening 3 and then sealed.

The first end of the biological bag 1 is provided with a liquid inlet 4, and the second end of the biological bag 1 is provided with a liquid outlet 5; after the fetus is placed in the biological bag 1, the head is placed at the liquid outlet 5 and the tail is placed at the liquid inlet 4.

The amniotic fluid input structure comprises a peristaltic pump 7, a flow sensor 8 and a filter 9; peristaltic pump 7, flow sensor 8 and filter 9 pass through pipeline fixed connection, and filter 9 rear end pipeline is connected on the liquid inlet 4 of biological bag 1 first end.

The oxygenator arteriovenous loop is detachably connected with the biological bag 1, and the amniotic fluid input structure is detachably connected with the biological bag 1.

The oxygenator arteriovenous loop comprises an oxygenator 2, a medicine/nutrient injection pump, a pressure sensor, a flow sensor 8, a gas mixing device, an oxygen/carbon dioxide gas sensor and a heat exchanger; the biological bag 1 is connected with the oxygenator 2 through three pipelines, two pipelines are connected with an umbilical artery, one pipeline is connected with an umbilical vein, a medicine/nutrient injection pump and a pressure sensor are arranged on the umbilical artery pipeline and then are connected with the oxygenator 2, and the oxygenator 2 is also connected with a flow sensor 8, a gas mixing device and an oxygen/carbon dioxide gas sensor to realize oxygen supply and carbon dioxide discharge of a living body; the umbilical vein pipeline is provided with a pressure sensor, a heart rate blood oxygen sensor, a flow sensor 8 and a heat exchanger to realize the supply of vital oxygen and nutrition and the long-term life development support.

The above description of embodiments is only for the understanding of the present invention. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present invention without departing from the principles of the invention, and such modifications will fall within the scope of the claims.

Claims

1. The bionic uterus system comprises a biological bag, a microfluidic oxygenator arteriovenous loop, an amniotic fluid input structure and a leak-proof structure, and is characterized in that the microfluidic oxygenator arteriovenous loop is detachably connected with the biological bag, and the amniotic fluid input structure is detachably connected with the biological bag; the liquid leakage preventing structure comprises a first leakage preventing structure and a second leakage preventing structure, the first leakage preventing structure is fixedly connected with the biological bag, the second leakage preventing structure is arranged on the first leakage preventing structure, and the second leakage preventing structure is detachably connected with the first leakage preventing structure; the first leakage-proof structure comprises a first cylindrical block and a baffle plate, wherein the baffle plate is arranged on the first cylindrical block and is movably connected with the first cylindrical block; the liquid leakage preventing structure is arranged in the area of the biological bag corresponding to the premature infant head; the liquid leakage preventing structure is an instrument provided with a guide channel for realizing the entrance of the saccule guide structure and a liquid leakage preventing one-way valve; guide channels for realizing the entrance of the balloon guide structure are arranged on the first leakage-proof structure and the second leakage-proof structure; the biological bag is provided with a surgical instrument placement hole for ensuring the balloon guiding structure to enter; a first groove is formed in the first side of the first cylindrical block, the first groove is circular, and the diameter of the first groove is smaller than that of the first round hole; a second groove is formed in the upper portion of the first groove of the first cylindrical block, the second groove is rectangular in shape, the length of the second groove is smaller than the diameter of the first groove, and the depth of the second groove is the same as that of the first groove; the two sides of the second groove are respectively provided with a second round hole, the baffle plate can be arranged in the second round holes, and the baffle plate moves along the second round holes; a third round hole is formed in the middle of the first cylindrical block, the third round hole is a through hole, and the diameter of the third round hole is smaller than that of the first groove; a third groove is formed in the second side of the first cylindrical block, and the diameter of the third groove is larger than that of the third round hole; threads are arranged on the outer side of the first cylindrical block; the baffle main body is a circular plate, the diameter of the circular plate is larger than that of the third circular hole, a rectangular plate is arranged at the upper part of the circular plate, the thickness of the rectangular plate is the same as that of the circular plate, a fourth groove is formed in the center of the top of the rectangular plate, and a connecting rod is arranged in the fourth groove; cylindrical rods are respectively arranged on two sides of the rectangular plate, the diameter of each cylindrical rod is the same as that of the second round hole, and the cylindrical rods can be arranged in the second round hole; the connecting rod is provided with a torsion spring, a first end of the torsion spring is pressed on the baffle plate, a second end of the torsion spring is pressed on the first cylindrical block, the torsion spring presses the baffle plate and the first cylindrical block, and the baffle plate is pressed on a third round hole of the first cylindrical block; a sealing gasket is arranged on one side, contacted with the first cylindrical block, of the baffle plate, the diameter of the sealing gasket is larger than that of the third round hole, and the sealing gasket is made of soft materials; the bottom of the first leakage-proof structure is provided with a fixing sheet which is fixed on the biological bag; the fixing piece is of any shape, a first round hole is formed in the middle of the fixing piece, and the diameter of the first round hole is larger than that of the surgical instrument placing hole; the fixing piece is provided with viscose, and can be directly adhered to the biological bag; the fixing piece is detachably connected with the first cylindrical block, and the first round hole on the fixing piece corresponds to the third round hole of the first cylindrical block; the second leakage-proof structure comprises a second cylindrical block, a round rod and a leakage-proof block; the first end of the round rod is fixedly connected with the second cylindrical block, and the second end of the round rod is fixedly connected with the leakage-proof block; a fourth groove is formed in the bottom of the second cylindrical block, and threads matched with the threads on the outer side of the first cylindrical block are formed in the fourth groove; a channel for the entry of the bronchoscope is arranged inside the round rod; the leak protection piece is cylindrical, and the top sets up the fifth recess, a fifth recess internal fixation leak protection piece, set up the cross opening in the middle of the leak protection piece, can block the liquid outflow and stretch into bronchoscope.

2. The biomimetic uterine system according to claim 1, wherein the first and second leak-proof structures are combined in a sealed manner, and the first and second leak-proof structures are combined by corresponding screw structures or by means of socket gluing.

3. The biomimetic uterine system of claim 1, wherein the surgical instrument insertion hole has a diameter that is larger than a diameter of the balloon guiding structure.

4. The biomimetic uterine system of claim 1, wherein the first end of the bio-bag is provided with a liquid inlet and the second end of the bio-bag is provided with a liquid outlet.

5. The biomimetic uterine system according to any one of claims 1-4, wherein the bio-bag is externally connected with a microfluidic oxygenator arteriovenous circuit, an amniotic fluid input structure and a leak-proof structure; the micro-fluidic oxygenator arteriovenous loop is detachably connected with the biological bag, and the amniotic fluid input structure is detachably connected with the biological bag; the amniotic fluid input structure comprises a peristaltic pump, a flow sensor and a filter; peristaltic pump, flow sensor and filter pass through pipeline fixed connection, and filter rear end pipeline connection is on the liquid inlet of biological bag first end.