CN115919534A

CN115919534A - Brain low-temperature perfusion apparatus

Info

Publication number: CN115919534A
Application number: CN202310245077.4A
Authority: CN
Inventors: 张慧涛; 汪娟; 李冰; 王轶; 刘洋; 黎宁君; 周育萍
Original assignee: Fifth Affiliated Hospital of Sun Yat Sen University
Current assignee: Fifth Affiliated Hospital of Sun Yat Sen University
Priority date: 2023-03-15
Filing date: 2023-03-15
Publication date: 2023-04-07

Abstract

The invention provides a low-temperature brain perfusion apparatus, belonging to the technical field of medical instruments; the perfusion apparatus comprises a perfusion apparatus main body, a liquid storage tank filled with cooling liquid is installed in the perfusion apparatus main body, a liquid outlet is fixedly connected to the bottom of the liquid storage tank, a first three-way electromagnetic valve is communicated with the liquid outlet, and a first guide pipe is communicated with one liquid outlet end of the first three-way electromagnetic valve. According to the invention, by arranging the liquid storage tank, the semiconductor refrigeration piece, the limiting part and the driving part, when the patient needs to be rewarmed, the driving part drives the limiting part to drive the heating surface of the semiconductor refrigeration piece to be attached to the liquid storage tank, so that the semiconductor refrigeration piece can heat the liquid storage tank, the blood in the patient is rewarmed, the heating electrical element is prevented from being directly contacted with the physiological saline, the oxidation damage of the heating electrical element is avoided, the long-term stable use of the device is facilitated, the service life of the device is ensured, and the risk of the operation is reduced.

Description

Brain low-temperature perfusion apparatus

Technical Field

The invention relates to the technical field of medical instruments, in particular to a low-temperature brain perfusion apparatus.

Background

The sub-hypothermia treatment is one of the treatment means of neurologic diseases, and the application conditions are mature. In the treatment of cerebral apoplexy, a whole body or local body surface cooling operation and low temperature are commonly used, a human body sub-low temperature controller is used in the treatment, the human body sub-low temperature controller controls the temperature and the flow of circulating liquid, and an instrument is used for physically cooling/heating the head and the whole body of a patient through an ice cap or an ice blanket, but the human body sub-low temperature controller has a plurality of complications when used for carrying out sub-low temperature treatment on the whole body, so that electrolyte disorder, arrhythmia and blood coagulation dysfunction are easily caused, and the clinical use is limited; if the head of the patient is physically cooled only by using the ice cap, the surface temperature can be reduced only because the blood supply of the scalp and the skull is rich, and the intracranial brain tissue of the patient is cooled very slowly.

In order to improve the regulation speed of the human body temperature in the operation process, the Chinese patent with the publication number of CN103417325B discloses a sub-low temperature treatment-blood vessel internal heat exchange body temperature accurate control device, which consists of three parts, namely an intravascular catheter system, an extracorporeal saline circulation system and a heat exchange controller. The intravascular catheter system is connected with the extracorporeal saline water circulating system through a pipeline to form a closed-loop saline water flow channel. The circulating water pump controls the sterile saline water to flow in the closed loop channel, the heat exchange coil is soaked in the refrigerant, and the temperature of the refrigerant can be changed by heating the refrigerating device, so that the temperature of the sterile saline water is adjusted. The heat exchange controller consists of a heating and refrigerating device, a temperature control system and a display operation unit, and is connected through a circuit. The heat exchange controller can change the temperature of saline in the extracorporeal saline circulation system, so that the intravascular catheter system can obtain temperature-controlled saline, and the temperature-controlled saline can exchange heat with blood of a patient through the surface of the balloon of the catheter system, and the aim of adjusting the core body temperature of a high-risk patient or a low-temperature patient in the central system is fulfilled.

Although the device realizes the adjustment of the body temperature of a patient by changing the temperature of the saline in extracorporeal circulation, the device is simple and easy to operate, but most of conventional heat exchange coils are made in a mode that heat conducting metal is sleeved outside an electric heating wire, in the heating process of the physiological saline, the heat conducting metal outside the heat exchange coils can be oxidized by salt in an accelerated mode, meanwhile, the surface of the heat conducting metal is easily oxidized into small holes by long-time high-temperature heating, the physiological saline is in contact with the electric heating wire in the heat conducting metal pipe, the conductivity of the saline-added water is stronger, the electric heating wire is easy to be in short circuit or short circuit, so that the current is instantly changed to be large to cause short circuit, the long-term stable use of the device is not facilitated, the service life of the device is shortened, the risk of an operation is increased, and therefore, the brain low-temperature perfusion instrument is provided to meet the requirements.

Disclosure of Invention

The invention aims to solve the technical problem of providing a brain low-temperature perfusion apparatus so as to solve the problems that in the process of heating physiological saline of the existing sub-low-temperature therapeutic apparatus, heat-conducting metal outside a heat exchange coil is oxidized by salt in an accelerated way, meanwhile, long-time high-temperature heating is easy to oxidize fine holes on the surface of the heat-conducting metal, the physiological saline is in contact with an electric heating wire in the heat-conducting metal pipe, the conductivity of water added with salt is stronger, the electric heating wire is easy to be short-circuited or short-circuited, the current is very large in transient, short circuit is caused, the long-term stable use of the apparatus is not facilitated, the service life of the apparatus is shortened, and the risk of operation is increased.

In order to solve the technical problems, the invention provides the following technical scheme:

the brain low-temperature perfusion apparatus comprises a perfusion apparatus main body, wherein a liquid storage tank filled with cooling liquid is installed in the perfusion apparatus main body, a liquid outlet is fixedly connected to the bottom of the liquid storage tank, a first three-way electromagnetic valve is communicated with the liquid outlet, one liquid outlet end of the first three-way electromagnetic valve is communicated with a first conduit, the liquid outlet end of the first conduit is communicated with a heat exchanger, a first pump body used for pumping cooling liquid in the liquid storage tank into the heat exchanger through the first conduit is installed on the first conduit, one liquid outlet end of the heat exchanger is communicated with a second conduit, one end, away from the heat exchanger, of the second conduit is communicated with a second three-way electromagnetic valve, the liquid inlet end of the second three-way electromagnetic valve is communicated with the liquid storage tank, the other liquid inlet end of the heat exchanger is communicated with a collection pipe, one end, away from the heat exchanger, of the collection pipe is communicated with a blood vessel in a patient, the other liquid outlet end of the heat exchanger is communicated with a liquid injection pipe, and a second pump body used for pumping blood in the liquid injection pipe back into the patient is installed on the perfusion apparatus main body; the perfusion apparatus main body is provided with a plurality of body temperature sensors for measuring the body temperature of a patient; the semiconductor refrigerating sheet drives the semiconductor refrigerating sheet to move by driving the limiting part, the semiconductor refrigerating sheet enables a heating surface or a refrigerating surface to be attached to the outer surface of the liquid storage tank by rotating, the cross section of the liquid storage tank is polygonal, a shunting part and a drainage part which are connected are arranged in the liquid storage tank, the shunting part is used for uniformly dispersing and guiding cooling liquid entering the liquid storage tank to the drainage part, and the drainage part is used for prolonging the contact time of the cooling liquid shunted by the shunting part and the side wall of the liquid storage tank; the driving part comprises a mounting shell fixedly connected in the perfusion apparatus main body, a servo motor is fixedly connected to the mounting shell, a driving gear is fixedly connected to the output end of the servo motor, a plurality of fixed shafts are rotatably sleeved on the mounting shell, driven gears meshed with the driving gear are fixedly connected to the fixed shafts, and the driving gear and the driven gears are both positioned in the mounting shell; the fixed shaft is rotatably sleeved with the liquid storage tank; the limiting component comprises a limiting frame fixedly sleeved on the fixed shaft, and the limiting frame is used for limiting the semiconductor refrigerating sheet; and the side wall of the liquid storage tank is fixedly connected with a plurality of heat conducting pads matched with the number of the semiconductor refrigerating sheets.

Preferably, the bottom of liquid storage pot is the back taper, the fixed catch tray that has cup jointed the slope and place on the liquid outlet of liquid storage pot, install the cover on the liquid storage pot, second three-way solenoid valve with the cover is linked together, another feed liquor end intercommunication of second three-way solenoid valve has the third pipe, be provided with the third pump body on the third pipe, another play liquid end intercommunication of first three-way solenoid valve has the fluid-discharge tube.

Preferably, the drainage component includes a plurality of fixed plates fixedly connected to the inner wall of the liquid storage tank, the diversion component includes a plurality of same distribution plates clamped to the fixed plates, the top of each distribution plate is arc-shaped, a plurality of first distribution plates and second distribution plates are fixedly connected to the distribution plates in a circumferentially uniform distribution manner, the first distribution plates are located in the middle of the distribution plates, the second distribution plates are located at the edge positions of the distribution plates, a plurality of same flow stabilizing sleeves are fixedly connected to the first distribution plates, the flow stabilizing sleeves are not in contact with the distribution plates, the liquid outlet ends of the second three-way solenoid valves are communicated with connecting pipes which penetrate through the tank cover and are sleeved with the flow stabilizing sleeves, one side of the second distribution plates, which is far away from the center of the distribution plates, is abutted to the inner wall of the liquid storage tank, a plurality of liquid guide ports, which are the same number as the second distribution plates, are located between two adjacent second distribution plates, and the liquid guide ports extend into the fixed plates.

Preferably, the cross sections of the first splitter plate and the second splitter plate are V-shaped, and rounded corners are formed at the tip portions of the first splitter plate and the second splitter plate.

Preferably, the drainage part still includes fixed connection and is in the fixed plate is close to two first water conservancy diversion strips of liquid storage pot inner wall one side, two one side fixedly connected with a plurality of second water conservancy diversion strips of staggering each other that first water conservancy diversion strip is close to each other, the water conservancy diversion inclined plane has all been seted up at the top of second water conservancy diversion strip, the width of drain mouth is less than two interval between the first water conservancy diversion strip, the bottom of drain mouth is less than the top of first water conservancy diversion strip.

Preferably, the bottom of the diverter tray is fixedly connected with a plurality of second clamping blocks, the number of the second clamping blocks is matched with that of the fixing plates, and the second clamping blocks abut against the top of the fixing plates.

Preferably, a plurality of grooves matched with the inner side of the second splitter plate are formed in the splitter plate, a connecting frame is fixedly connected to the bottom of the splitter plate, a liquid level sensor and a water temperature sensor are fixedly connected to the connecting frame, and a monitoring sensor module used for detecting the state of blood flowing back to the patient body through a liquid injection pipe is further installed on the liquid storage tank.

Preferably, the inboard fixedly connected with of spacing frame two with the first spacing muscle of semiconductor refrigeration piece looks adaptation, first spacing muscle runs through spacing frame, the draw-in groove has all been seted up at the both ends of spacing frame, spacing frame go up the joint have with the spacing of draw-in groove looks adaptation, two fixedly connected with on the spacing with the spacing muscle of second of semiconductor refrigeration piece side looks adaptation, the first fixture block of bottom fixedly connected with of spacing, the top fixedly connected with arm-tie of spacing, the wire casing has been seted up on the spacing frame.

Preferably, a plurality of groups of limiting angles matched with the appearance of the heat conducting pad are fixedly connected to the side wall of the liquid storage tank, each group of limiting angles comprises four limiting angles, and the four limiting angles are respectively matched with four corners of the heat conducting pad.

Preferably, a control panel is further installed on the perfusion apparatus main body, a control unit is arranged on the control panel, and the control unit is electrically connected with the semiconductor refrigeration piece, the first three-way electromagnetic valve, the first pump body, the second three-way electromagnetic valve, the second pump body, the monitoring sensor module, the third pump body, the body temperature sensor, the servo motor, the liquid level sensor and the water temperature sensor.

Compared with the prior art, the invention at least has the following beneficial effects:

among the above-mentioned scheme, through setting up the liquid storage pot, the semiconductor refrigeration piece, stop part, driver part, when needs carry out rewarming to the patient, drive stop part through driver part drive semiconductor refrigeration piece's heating surface and liquid storage pot subsides and touch, make the semiconductor refrigeration piece can heat the liquid storage pot, and realize rewarming of the internal blood of patient, avoid heating electrical components and normal saline direct contact, thereby the heating electrical components oxidation damage that causes, be favorable to the long-term stable use of this device, the life of this device has been ensured, the risk of operation has been reduced.

Through setting up the liquid storage pot, the semiconductor refrigeration piece, when needs are cooled down to the patient, make semiconductor refrigeration piece circular telegram work, a plurality of semiconductor refrigeration piece circular telegrams and cool down the liquid storage pot, through first three-way solenoid valve, the refrigerated coolant pump in the first pump body is to heat exchanger in, cool down to heat exchanger, and through the second pipe, second three-way solenoid valve pump returns the liquid storage pot, will get into in the heat exchanger through the acquisition pipe through the second pump body simultaneously, and by in the blood of the cooling of heat exchanger cooling pump back to the patient through annotating the liquid pipe in vivo, realize patient's rapid cooling, use patient self blood, through closed loop's extrinsic cycle, after cooling down to blood, fill into the intracranial artery of patient, with reach the low temperature control to patient's cranium fast, reduce the patient and appear rejection, the hemolysis, the probability that the disease propagated, reduce the treatment risk.

Through setting up the fluid-discharge tube, when the coolant liquid in the liquid storage tank is got rid of to needs, adjust first three way solenoid valve and can discharge the coolant liquid in the liquid storage tank through the fluid-discharge tube, through setting up the third pipe, when needs add the coolant liquid to the liquid storage tank in, adjust second three way solenoid valve, can go into the liquid storage tank with outside coolant liquid through the third pipe, second three way solenoid valve pump through the third pump body, accomplish the interpolation of coolant liquid, simple structure, simple operation.

Through setting up the reposition of redundant personnel part, the coolant liquid that is influenced by the blood temperature in the heat exchanger flows into the liquid storage tank through the second pipe, second three way solenoid valve, the connecting pipe, the guide through steady flow cover and first reposition of redundant personnel makes the coolant liquid homodisperse that flows on the reposition of redundant personnel dish, and under the guide of second reposition of redundant personnel board, each lateral wall of liquid storage tank is evenly flowed to through the drain mouth, through contacting with the lateral wall, improve the heating and refrigerating speed of coolant liquid, through first reposition of redundant personnel board, the fillet that second reposition of redundant personnel board point portion was seted up reduces the turbulent intensity when coolant liquid and first reposition of redundant personnel board, second reposition of redundant personnel board contacted, reduce first reposition of redundant personnel board, the second reposition of redundant personnel board influences the velocity of flow of coolant liquid that flows on the reposition of redundant personnel dish, moreover, the steam generator is simple in structure, and convenient to use.

Through setting up the drainage part, coolant liquid in the liquid guide mouth inflow fixed plate blocks down at a plurality of second water conservancy diversion strips, the falling speed of its height has been slowed down, the contact time of coolant liquid and stock solution jar lateral wall has been increased, further improve the governing speed of coolant liquid temperature, through setting up the water conservancy diversion inclined plane, avoid coolant liquid to be detained on the second water conservancy diversion strip, and then reduce the use amount of coolant liquid in the stock solution jar, improve the availability factor of coolant liquid, through setting up the liquid guide mouth, first water conservancy diversion strip, under the blockking of a plurality of second water conservancy diversion strips that are mutually wrong, flow speed is showing and is descending, if this moment, when having the coolant liquid long-pending on the second water conservancy diversion strip, the coolant liquid long-pending on the second water conservancy diversion strip can overflow first water conservancy diversion strip, directly flow in the bottom of stock solution jar through the clearance between first water conservancy diversion strip and the fixed plate, guarantee that the use of coolant liquid is stable.

Drawings

The accompanying drawings, which are incorporated herein and constitute part of the specification, illustrate embodiments of the disclosure and, together with the description, further serve to explain the principles of the disclosure and to enable a person skilled in the pertinent art to make and use the disclosure.

FIG. 1 is a schematic diagram of a cryobrain perfusion apparatus system;

FIG. 2 is a schematic view of an assembled three-dimensional structure of a liquid storage tank, a semiconductor refrigeration sheet, a limiting component and a driving component;

FIG. 3 is a schematic view of a three-dimensional enlarged structure of the semiconductor chilling plate and a limiting component after assembly;

FIG. 4 is a partially cut-away enlarged perspective view of the reservoir;

FIG. 5 is a schematic perspective view of the diverter tray;

FIG. 6 is an enlarged view of the structure at A in FIG. 4;

FIG. 7 is a schematic view of a three-dimensional enlarged structure of the diverter tray, the liquid level sensor and the water temperature sensor after assembly;

FIG. 8 is a schematic perspective view of an assembled fluid reservoir and thermal pad;

FIG. 9 is a schematic view of a partially enlarged structure of the position-limiting frame;

FIG. 10 is a schematic view of a partially enlarged structure of the stopper;

[ reference numerals ]

1. A perfusion apparatus main body; 2. a liquid storage tank; 3. a semiconductor refrigeration sheet; 4. a limiting component; 5. a drive member; 6. a flow dividing member; 7. a drainage component; 8. a first three-way solenoid valve; 9. a first conduit; 10. a first pump body; 11. a heat exchanger; 12. a second conduit; 13. a second three-way solenoid valve; 14. a collection tube; 15. a liquid injection pipe; 16. a second pump body; 17. monitoring the sensor module; 18. a third conduit; 19. a liquid discharge pipe; 20. a third pump body; 21. a body temperature sensor; 22. mounting a shell; 23. a servo motor; 24. a driving gear; 25. a fixed shaft; 26. a driven gear; 27. a limiting frame; 28. a first limiting rib; 29. a wire slot; 30. a card slot; 31. a limiting strip; 32. a first clamping block; 33. a second limiting rib; 34. pulling a plate; 35. a diverter tray; 36. a first splitter plate; 37. a flow stabilizing sleeve; 38. a second splitter plate; 39. a groove; 40. a liquid guide port; 41. a fixing plate; 42. a first flow guide strip; 43. a second flow guide strip; 44. a flow guide inclined plane; 45. a second fixture block; 46. a connecting frame; 47. a liquid level sensor; 48. a water temperature sensor; 49. a thermally conductive pad; 50. limiting the angle; 51. a can lid; 52. and a liquid collecting disc.

As shown, specific structures and devices are labeled in the figures to clearly realize the structures of the embodiments of the present invention, but this is only an illustration and is not intended to limit the present invention to the specific structures, devices and environments, and one of ordinary skill in the art can adjust or modify the devices and environments according to specific needs, and the adjusted or modified devices and environments are still included in the scope of the appended claims.

Detailed Description

The brain low-temperature perfusion apparatus provided by the invention is described in detail below with reference to the accompanying drawings and specific embodiments. Meanwhile, it is described herein that the following embodiments are the best and preferred embodiments for the purpose of making the embodiments more detailed, and may be implemented in other alternative ways by those skilled in the art; also, the drawings are only for purposes of more particularly describing embodiments and are not intended to limit the invention in any way.

It should be noted that references in the specification to "one embodiment," "an example embodiment," "some embodiments," etc., indicate that the embodiment described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic. Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it is submitted that it is within the knowledge of one skilled in the relevant art to effect such feature, structure, or characteristic in connection with other embodiments whether or not explicitly described.

In general, terms may be understood at least in part from the context in which they are used. For example, the term "one or more" as used herein may be used to describe any feature, structure, or characteristic in the singular or may be used to describe a combination of features, structures, or characteristics in the plural, depending at least in part on the context. Additionally, the term "based on" may be understood as not necessarily intended to convey an exclusive set of factors, but may instead allow for the presence of other factors not necessarily explicitly described, depending at least in part on the context.

It is to be understood that the meaning of "on … …", "over … …" and "over … …" in this disclosure should be interpreted in the broadest manner such that "on … …" means not only "directly on" something "but also includes the meaning of" on "something with intervening features or layers therebetween, and" over … … "or" over … … "means not only" over "or" over "something" but may also include the meaning of "over" or "over" something without intervening features or layers therebetween.

Furthermore, spatially relative terms such as "below …", "below …", "lower", "above …", "upper", and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or feature, as shown in the figures. Spatially relative terms are intended to encompass different orientations in use or operation of the device in addition to the orientation depicted in the figures. The device may be otherwise oriented and the spatially relative descriptors used herein interpreted accordingly.

As shown in fig. 1-3, 9 and 10, an embodiment of the invention provides a low-temperature perfusion apparatus for brain, which includes a perfusion apparatus main body 1, a liquid storage tank 2 filled with cooling liquid is installed in the perfusion apparatus main body 1, a liquid outlet is fixedly connected to the bottom of the liquid storage tank 2, a first three-way electromagnetic valve 8 is communicated with the liquid outlet, one liquid outlet end of the first three-way electromagnetic valve 8 is communicated with a first conduit 9, the liquid outlet end of the first conduit 9 is communicated with a heat exchanger 11, a first pump body 10 for pumping cooling liquid in the liquid storage tank 2 into the heat exchanger 11 through the first conduit 9 is installed on the first conduit 9, one liquid outlet end of the heat exchanger 11 is communicated with a second conduit 12, one end of the second conduit 12, which is far away from the heat exchanger 11, is communicated with a second three-way electromagnetic valve 13, the liquid inlet end of the second three-way electromagnetic valve 13 is communicated with the liquid storage tank 2, the other liquid inlet end of the heat exchanger 11 is communicated with a collection pipe 14, one end of the collection pipe 14, which is far away from the heat exchanger 11, the liquid outlet end of the heat exchanger 11 is communicated with a blood vessel, the liquid storage tank is provided with a communication pipe 15, and a second pump body 16 for returning blood pump body provided with a conventional perfusion apparatus is installed on the perfusion apparatus main body 16; a plurality of body temperature sensors 21 for measuring the body temperature of a patient are mounted on the perfusion apparatus main body 1; the semiconductor refrigeration device is characterized by further comprising a plurality of semiconductor refrigeration pieces 3 used for heating or refrigerating the liquid storage tank 2, a limiting part 4 used for limiting the semiconductor refrigeration pieces 3 is installed on the liquid storage tank 2, a driving part 5 used for driving the limiting part 4 to drive the semiconductor refrigeration pieces 3 to move is installed on the limiting part 4, the semiconductor refrigeration pieces 3 enable a heating surface or a refrigerating surface to be attached to the outer surface of the liquid storage tank 2 through rotation, the cross section of the liquid storage tank 2 is polygonal, a shunting part 6 and a drainage part 7 which are connected are installed in the liquid storage tank 2, the shunting part 6 is used for uniformly dispersing and guiding cooling liquid entering the liquid storage tank 2 to the drainage part 7, and the drainage part 7 is used for prolonging the contact time of the cooling liquid shunted by the shunting part 6 and the side wall of the liquid storage tank 2; the driving part 5 comprises a mounting shell 22 fixedly connected in the perfusion apparatus main body 1, a servo motor 23 is fixedly connected on the mounting shell 22, a driving gear 24 is fixedly connected at the output end of the servo motor 23, a plurality of fixing shafts 25 are rotatably sleeved on the mounting shell 22, driven gears 26 meshed with the driving gear 24 are fixedly connected on the fixing shafts 25, and the driving gear 24 and the driven gears 26 are both positioned in the mounting shell 22; the fixed shaft 25 is rotatably sleeved with the liquid storage tank 2; the limiting component 4 comprises a limiting frame 27 fixedly sleeved on the fixed shaft 25, and the limiting frame 27 is used for limiting the semiconductor refrigerating sheet 3; fixedly connected with a plurality of heat conduction pads 49 with 3 quantity looks adaptations of semiconductor refrigeration piece on the lateral wall of liquid storage pot 2, reduce liquid storage pot 2 through setting up heat conduction pad 49, semiconductor refrigeration piece 3 is close to one side each other because of the unsmooth contact that leads to in surface is not abundant, thereby the decay of the heat conduction efficiency who causes, improve semiconductor refrigeration piece 3's heating refrigeration effect, still install the fan in perfusion appearance main part 1, be used for carrying out the forced air cooling to semiconductor refrigeration piece 3 heating surface, guarantee that the use of 3 refrigeration functions of semiconductor refrigeration piece is stable.

Through setting up liquid storage pot 2, semiconductor refrigeration piece 3, when needs are cooled down to the patient, make semiconductor refrigeration piece 3 work of circular telegram, a plurality of semiconductor refrigeration pieces 3 circular telegram and cool down liquid storage pot 2, through first three-way solenoid valve 8, first pump body 10 is with the refrigerated coolant pump in the liquid storage pot 2 to in heat exchanger 11, cool down heat exchanger 11, and through second pipe 12, second three-way solenoid valve 13 pump back liquid storage pot 2, will get into in heat exchanger 11 through collection pipe 14 simultaneously through the second pump body 16, and the blood that is cooled down by the coolant pump in heat exchanger 11 is in the patient through annotating liquid pipe 15, realize patient's rapid cooling, use patient's own blood, through closed loop's extrinsic cycle, after cooling down blood, pour into patient's intracranial artery, in order to reach the low temperature control to patient's cranium fast, reduce the patient and appear the rejection, hemolysis, the probability of disease propagation, reduce the treatment risk.

Through setting up liquid storage pot 2, semiconductor refrigeration piece 3, stop part 4, driver part 5, when needs carry out rewarming to the patient, start servo motor 23, servo motor 23 passes through driving gear 24 and drives a plurality of driven gear 26 synchronous rotations, driven gear 26 passes through fixed axle 25, spacing frame 27 drives semiconductor refrigeration piece 3 and rotates and move to the adjacent side of liquid storage pot 2, the heating surface of semiconductor refrigeration piece 3 pastes with liquid storage pot 2 this moment and touches, make semiconductor refrigeration piece 3 circular telegram work, can heat liquid storage pot 2, and realize the rewarming of patient's internal blood, the benefit that sets up like this is, avoid heating electrical components and normal saline direct contact, thereby the heating electrical components oxidation damage that causes, be favorable to the long-term stable use of this device, the life of this device has been ensured, the risk of operation has been reduced, and carry out make full use to semiconductor refrigeration piece 3, and is ingenious practical.

As shown in fig. 1 and fig. 2, in this embodiment, a tank cover 51 is installed on the liquid storage tank 2, the second three-way electromagnetic valve 13 is communicated with the tank cover 51, another liquid inlet end of the second three-way electromagnetic valve 13 is communicated with the third conduit 18, the third conduit 18 is provided with a third pump body 20, another liquid outlet end of the first three-way electromagnetic valve 8 is communicated with the liquid discharge pipe 19, by providing the liquid discharge pipe 19, when the cooling liquid in the liquid storage tank 2 needs to be discharged, the cooling liquid in the liquid storage tank 2 can be discharged through the liquid discharge pipe 19 by adjusting the first three-way electromagnetic valve 8, and by providing the third conduit 18, when the cooling liquid needs to be added into the liquid storage tank 2, the second three-way electromagnetic valve 13 can be adjusted, and the external cooling liquid can be pumped into the liquid storage tank 2 through the third conduit 18 and the second three-way electromagnetic valve 13 by the third pump body 20, so as to complete the addition of the cooling liquid, and the structure is simple and convenient to operate.

As shown in fig. 4-6, in the present embodiment, the drainage component 7 includes a plurality of fixing plates 41 fixedly connected to the inner wall of the liquid storage tank 2, the diversion component 6 includes a same diversion plate 35 clamped to the plurality of fixing plates 41, the top of the diversion plate 35 is arc-shaped, a plurality of first diversion plates 36 and second diversion plates 38 are fixedly connected to the diversion plate 35 in a circumferentially uniform distribution manner, the first diversion plates 36 are located in the middle of the diversion plate 35, the second diversion plates 38 are located at the edge of the diversion plate 35, a same flow stabilizing sleeve 37 is fixedly connected to the plurality of first diversion plates 36, the flow stabilizing sleeve 37 is not in contact with the diversion plate 35, a connecting pipe penetrating through a tank cover 51 and sleeved with the flow stabilizing sleeve 37 is communicated with a liquid outlet end of the second three-way electromagnetic valve 13, one side of the second diversion plate 38 far from the center of the diversion plate 35 is abutted against the inner wall of the liquid storage tank 2, a plurality of liquid guiding ports 40 having the same number as the second diversion plates 38 are formed in the diversion plate 35, the liquid guiding ports 40 are located between two adjacent second diversion plates 38, the liquid guiding ports 40 extend into the fixing plates 41, the first diversion plates 36, the cross section of the first diversion plate 36 is a rounded corner 38, and the first diversion plate 36 is formed in a rounded corner 38.

By arranging the flow dividing component 6, the cooling liquid influenced by the temperature of the blood in the heat exchanger 11 flows into the liquid storage tank 2 through the second conduit 12, the second three-way electromagnetic valve 13 and the connecting pipe, the cooling liquid flowing on the flow dividing disc 35 is uniformly dispersed by the guide of the flow stabilizing sleeve 37 and the first flow dividing plate 36, and under the guide of the second flow dividing plate 38, the cooling liquid uniformly flows to each side wall of the liquid storage tank 2 through the liquid guide port 40, and is contacted with the side wall, so that the heating and refrigerating speed of the cooling liquid is improved, the turbulence intensity when the cooling liquid is contacted with the first flow dividing plate 36 and the second flow dividing plate 38 is reduced through the round angle formed at the tip part of the first flow dividing plate 36 and the second flow dividing plate 38, and the influence of the flow speed of the cooling liquid flowing on the flow dividing disc 35 by the first flow dividing plate 36 and the second flow dividing plate 38 is reduced, the structure is simple and convenient to use.

As shown in fig. 4 and fig. 6, in this embodiment, the drainage component 7 further includes two first flow guide strips 42 fixedly connected to one side of the fixing plate 41 close to the inner wall of the fluid reservoir 2, one side of the two first flow guide strips 42 close to each other is fixedly connected with a plurality of second flow guide strips 43 which are staggered, the top of each second flow guide strip 43 is provided with a flow guide inclined surface 44, the width of the fluid guide port 40 is smaller than the distance between the two first flow guide strips 42, and the bottom of the fluid guide port 40 is lower than the top of the first flow guide strip 42.

By arranging the drainage component 7, the cooling liquid flowing into the fixing plate 41 through the liquid guide port 40 is blocked by the second flow guide strips 43, the descending speed of the height of the cooling liquid is slowed down, the contact time of the cooling liquid and the side wall of the liquid storage tank 2 is increased, the adjusting speed of the temperature of the cooling liquid is further improved, by arranging the flow guide inclined plane 44, the cooling liquid is prevented from being retained on the second flow guide strips 43, the usable amount of the cooling liquid in the liquid storage tank 2 is further reduced, the use efficiency of the cooling liquid is improved, by arranging the liquid guide port 40 and the first flow guide strips 42, when the cooling liquid is blocked by the second flow guide strips 43 which are staggered, the flowing speed is remarkably reduced, if at the moment, the cooling liquid retained on the second flow guide strips 43 can flow over the first flow guide strips 42, and directly flows into the bottom of the liquid storage tank 2 through the gap between the first flow guide strips 42 and the fixing plate 41, and the use stability of the cooling liquid is guaranteed.

As shown in fig. 4, 6 and 7, in the present embodiment, a plurality of second stoppers 45 corresponding to the number of the fixing plates 41 are fixedly connected to the bottom of the diversion disc 35, and the second stoppers 45 abut against the top of the fixing plates 41.

Through setting up second fixture block 45, when installing diverter plate 35, aim at the lateral wall of liquid storage pot 2 with drain port 40 and along the vertical decline in the center of liquid storage pot 2 until second fixture block 45 contradicts with fixed plate 41 and can accomplish the installation of diverter plate 35, simple structure, it is convenient to use, has improved diverter plate 35's dismantlement maintenance convenience.

As shown in fig. 3, fig. 9 and fig. 10, in this embodiment, two first limiting ribs 28 with the adaptation of semiconductor refrigeration piece 3 are fixedly connected to the inboard of limiting frame 27, first limiting rib 28 runs through limiting frame 27, draw-in groove 30 has all been seted up at the both ends of limiting frame 27, limiting frame 27 is last to be connected with the limiting strip 31 with the adaptation of draw-in groove 30, two second limiting ribs 33 with the adaptation of semiconductor refrigeration piece 3 side looks of fixedly connected with on the limiting strip 31, the first fixture block 32 of bottom fixedly connected with of limiting strip 31, the top fixedly connected with arm-tie 34 of limiting strip 31, wire casing 29 has been seted up on the limiting frame 27.

Through setting up spacing frame 27, spacing 31, when installing semiconductor refrigeration piece 3, with semiconductor refrigeration piece 3 along spacing frame 27 opening side slide in spacing frame 27, through spacing frame 27, it is spacing that first spacing muscle 28 carries out the joint to semiconductor refrigeration piece 3, and realize semiconductor refrigeration piece 3's complete spacing through the grafting of spacing 31 and draw-in groove 30, realize spacing 31 fixed through the joint of first fixture block 32 with spacing frame 27 and the conflict of arm-tie 34 with spacing frame 27, with the spacing stability of guarantee semiconductor refrigeration piece 3, structural strength through setting up first spacing muscle 28 and having improved spacing frame 27, when avoiding spacing frame 27 to drive semiconductor refrigeration piece 3 and heat conduction pad 49 conflict, receive the reaction effect influence of heat conduction pad 49 to make semiconductor refrigeration piece 3 drive spacing frame 27 atress warp, influence the stability in use of spacing frame 27 and the laminating effect of semiconductor refrigeration piece 3 with heat conduction pad 49, improve the structural strength of spacing 31 through setting up second spacing muscle 33, with further strengthen the spacing effect of semiconductor refrigeration piece 3.

Through setting up first fixture block 32, arm-tie 34, when semiconductor refrigeration piece 3 needs to be changed, press first fixture block 32, carry and draw arm-tie 34 and can relieve the spacing of 3 sides of semiconductor refrigeration piece, can realize the dismantlement of semiconductor refrigeration piece 3 along spacing frame 27 roll-off with semiconductor refrigeration piece 3 this moment, simple structure, it is convenient to use.

As shown in fig. 8, in the present embodiment, a plurality of sets of limiting angles 50 adapted to the shape of the thermal pad 49 are fixedly connected to the side wall of the liquid storage tank 2, each set of limiting angles 50 includes four limiting angles 50, the four limiting angles 50 are respectively adapted to the four corners of the thermal pad 49, and by setting the limiting angles 50, the thermal pad 49 is positioned during the installation process, so as to improve the installation convenience of the thermal pad 49.

As shown in fig. 2 and fig. 3, in this embodiment, the bottom of the liquid storage tank 2 is in an inverted cone shape, a liquid collection tray 52 placed in an inclined manner is fixedly sleeved on a liquid outlet of the liquid storage tank 2, and by arranging the liquid collection tray 52, condensed water generated in the temperature adjustment process of the liquid storage tank 2 is guided out of the perfusion apparatus main body 1, so that the condensed water is prevented from being accumulated in the perfusion apparatus main body 1 and affecting the use stability of electrical components in the perfusion apparatus main body 1.

As shown in fig. 1, 5 and 7, in this embodiment, a plurality of grooves 39 adapted to the inner side of the second splitter plate 38 are formed on the splitter plate 35, a connecting frame 46 is fixedly connected to the bottom of the splitter plate 35, a liquid level sensor 47 and a water temperature sensor 48 are fixedly connected to the connecting frame 46, a monitoring sensor module 17 for detecting the state of blood flowing back to the patient through the injection tube 15 is further installed on the liquid storage tank 2, the safety monitoring sensor module 17 can be a bubble detection sensor (optical pair tube) in the prior art, and is composed of a pressure (pressure strain gauge) and a temperature sensor (PT 100), vapor bubble detection is the light intensity after light is scattered by bubbles, and is converted into an electrical signal by a phototriode and then digitally converted into a numerical value, and the numerical value is subjected to an empirical value numerical value fitting curve to obtain a bubble content numerical value, a control panel is further installed on the perfusion apparatus main body 1, a control unit is provided on the control panel, and the control unit is electrically connected to the semiconductor refrigeration sheet 3, the first three-way electromagnetic valve 8, the first three-way electromagnetic valve 10, the second electromagnetic valve 13, the second pump 16, the monitoring sensor 17, the third pump 20, the body temperature sensor 21, the body temperature sensor, the servo sensor 23, and the liquid level sensor 47, and the servo motor 48.

Control the electrical components on perfusion apparatus main part 1 through setting up control panel, the effectual operation convenience that improves this device, before the treatment, laminate body temperature sensor 21 and patient's head surface, through monitoring patient's head epidermis temperature, through empirical fitting curve, convert to intracranial temperature, control semiconductor refrigeration piece 3 through control panel and heat or lower the temperature to the coolant liquid, change the coolant liquid temperature, monitor the temperature of coolant liquid in the liquid storage pot 2 through water temperature sensor 48, control first pump body 10 through control panel, second pump body 16 changes blood, the temperature control of coolant liquid velocity of flow cooperation coolant liquid makes blood reach the cooling curve or the curve of heating up of settlement, through safety monitoring sensor module 17 to blood injection pressure, the detection of bubble content guarantees the safety of injecting blood, send the warning when the parameter index is greater than or less than the safe value through the bee calling organ that sets up on perfusion apparatus main part 1, remind the control personnel, simultaneously can be long-time carry out the selectivity to patient's cranium hypothermia, accurate sub-temperature control, also can keep the low temperature of slow heating curve when ending sub-treatment, be favorable to the patient, the gentle promotion of the blood of the use of this device that improves more gently.

According to the technical scheme provided by the invention, by arranging the liquid storage tank 2 and the semiconductor refrigeration sheets 3, when a patient needs to be cooled, the semiconductor refrigeration sheets 3 are electrified to work, the plurality of semiconductor refrigeration sheets 3 are electrified to cool the liquid storage tank 2, the cooled cooling liquid in the liquid storage tank 2 is pumped into the heat exchanger 11 through the first three-way electromagnetic valve 8 and the first pump body 10 to cool the heat exchanger 11, and is pumped back to the liquid storage tank 2 through the second conduit 12 and the second three-way electromagnetic valve 13, meanwhile, the blood which is cooled by the cooling liquid in the heat exchanger 11 enters the heat exchanger 11 through the collection pipe 14 through the second pump body 16 and is pumped back to the patient through the liquid injection pipe 15, so that the rapid cooling of the patient is realized, the patient's own blood is used, and is cooled through closed-loop extracorporeal circulation and then is poured into the intracranial artery of the patient, so that the low-temperature control of the cranium of the patient is rapidly achieved, the probability of rejection, hemolysis and disease propagation of the patient is reduced, and the treatment risk is reduced.

Through setting up fluid-discharge tube 19, when the coolant liquid in the liquid storage pot 2 is got rid of to needs, adjust first three way solenoid valve 8 and can discharge the coolant liquid in the liquid storage pot 2 through fluid-discharge tube 19, through setting up third pipe 18, when needs add the coolant liquid to the liquid storage pot 2 in, adjust second three way solenoid valve 13, can be through the third pump body 20 with outside coolant liquid through third pipe 18, in the liquid storage pot 2 is gone into to the pump of second three way solenoid valve 13, accomplish the interpolation of coolant liquid, moreover, the steam generator is simple in structure, and the simple operation is convenient.

Through setting up spacing frame 27, spacing 31, during installation semiconductor refrigeration piece 3, with semiconductor refrigeration piece 3 along spacing frame 27 opening side slide in spacing frame 27, through spacing frame 27, it is spacing that first spacing muscle 28 carries out the joint to semiconductor refrigeration piece 3, and realize semiconductor refrigeration piece 3's complete spacing through grafting of spacing 31 and draw-in groove 30, realize spacing 31 fixed through the joint of first fixture block 32 with spacing frame 27 and the conflict of arm-tie 34 with spacing frame 27, with guarantee semiconductor refrigeration piece 3's spacing stability, the structural strength of spacing frame 27 has been improved through setting up first spacing muscle 28, when avoiding spacing frame 27 to drive semiconductor refrigeration piece 3 and conflict with heat conduction pad 49, receive the reaction force influence of heat conduction pad 49 and make semiconductor refrigeration piece 3 drive spacing frame 27 atress warp, influence the stability in use of spacing frame 27 and the effect of pasting of semiconductor refrigeration piece 3 with heat conduction pad 49, improve the structural strength of spacing 31 through setting up spacing muscle 33 of second, with further strengthen the spacing effect of semiconductor refrigeration piece 3.

Through setting up drip pan 52, produce the comdenstion water guide outside perfusion apparatus main part 1 with liquid storage pot 2 in the temperature control process, avoid the comdenstion water long-pending in perfusion apparatus main part 1 to stay, influence the stability in use of electrical components in perfusion apparatus main part 1.

The invention is intended to cover alternatives, modifications, equivalents and alternatives which may be included within the spirit and scope of the invention. In the following description of the preferred embodiments of the present invention, specific details are set forth in order to provide a thorough understanding of the present invention, and it will be apparent to those skilled in the art that the present invention may be practiced without these specific details. In other instances, well-known methods, procedures, components, and circuits have not been described in detail as not to unnecessarily obscure aspects of the present invention.

Those skilled in the art will appreciate that all or part of the steps in the method for implementing the above embodiments may be implemented by relevant hardware instructed by a program, and the program may be stored in a computer readable storage medium, such as: ROM/RAM, magnetic disk, optical disk, etc.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.

Claims

1. Brain low temperature perfusion appearance, its characterized in that includes: the perfusion apparatus comprises a perfusion apparatus main body, wherein a liquid storage tank filled with cooling liquid is installed in the perfusion apparatus main body, a liquid outlet is fixedly connected to the bottom of the liquid storage tank, a first three-way electromagnetic valve is communicated with the liquid outlet, one liquid outlet end of the first three-way electromagnetic valve is communicated with a first conduit, the liquid outlet end of the first conduit is communicated with a heat exchanger, a first pump body used for pumping the cooling liquid in the liquid storage tank into the heat exchanger through the first conduit is installed on the first conduit, one liquid outlet end of the heat exchanger is communicated with a second conduit, one end, far away from the heat exchanger, of the second conduit is communicated with a second three-way electromagnetic valve, the liquid inlet end of the second three-way electromagnetic valve is communicated with the liquid storage tank, the other liquid inlet end of the heat exchanger is communicated with a collection pipe, one end, far away from the heat exchanger, of the collection pipe is communicated with a blood vessel in a patient, the other liquid outlet end of the heat exchanger is communicated with a liquid injection pipe, and a second pump body used for returning the blood pump in the liquid injection apparatus main body is installed on the liquid injection apparatus main body;

the perfusion apparatus main body is provided with a plurality of body temperature sensors for measuring the body temperature of a patient;

the semiconductor refrigeration piece is used for heating or refrigerating the liquid storage tank, a limiting component used for limiting the semiconductor refrigeration piece is installed on the liquid storage tank, a driving component used for driving the limiting component to drive the semiconductor refrigeration piece to move is installed on the limiting component, the semiconductor refrigeration piece enables a heating surface or a refrigerating surface to be attached to the outer surface of the liquid storage tank through rotation, the cross section of the liquid storage tank is polygonal, a shunting component and a drainage component which are connected are installed in the liquid storage tank, the shunting component is used for uniformly dispersing and guiding cooling liquid entering the liquid storage tank to the drainage component, and the drainage component is used for prolonging the contact time of the cooling liquid shunted by the shunting component and the side wall of the liquid storage tank;

the driving part comprises a mounting shell fixedly connected in the perfusion apparatus main body, a servo motor is fixedly connected to the mounting shell, a driving gear is fixedly connected to the output end of the servo motor, a plurality of fixed shafts are rotatably sleeved on the mounting shell, driven gears meshed with the driving gear are fixedly connected to the fixed shafts, and the driving gear and the driven gears are both positioned in the mounting shell;

the fixed shaft is rotatably sleeved with the liquid storage tank;

the limiting component comprises a limiting frame fixedly sleeved on the fixed shaft, and the limiting frame is used for limiting the semiconductor refrigerating sheet;

and the side wall of the liquid storage tank is fixedly connected with a plurality of heat conducting pads matched with the number of the semiconductor refrigerating sheets.

2. The brain low-temperature perfusion apparatus according to claim 1, wherein the bottom of the liquid storage tank is in an inverted cone shape, a liquid collection tray which is obliquely arranged is fixedly sleeved on a liquid outlet of the liquid storage tank, a tank cover is installed on the liquid storage tank, the second three-way electromagnetic valve is communicated with the tank cover, the other liquid inlet end of the second three-way electromagnetic valve is communicated with a third conduit, a third pump body is arranged on the third conduit, and the other liquid outlet end of the first three-way electromagnetic valve is communicated with a liquid discharge pipe.

3. The cerebral cryoperfusion apparatus according to claim 2, wherein the drainage component includes a plurality of fixing plates fixedly connected to the inner wall of the liquid storage tank, the distribution component includes a same distribution tray clamped to the fixing plates, the top of the distribution tray is arc-shaped, a plurality of first distribution plates and a plurality of second distribution plates are fixedly connected to the distribution tray in a circumferentially uniform distribution manner, the first distribution plates are located in the middle of the distribution tray, the second distribution plates are located at the edge of the distribution tray, a same flow stabilizing sleeve is fixedly connected to the first distribution plates, the flow stabilizing sleeve is not in contact with the distribution tray, a liquid outlet end of the second three-way solenoid valve is communicated with a connecting pipe penetrating through the tank cover and sleeved with the flow stabilizing sleeve, one side of the second distribution plate, which is far away from the center of the distribution tray, abuts against the inner wall of the liquid storage tank, a plurality of liquid guide ports, which are the same number as the second distribution plates, are formed in the distribution tray, the liquid guide ports are located between two adjacent second distribution plates, and extend into the fixing plates.

4. The low-temperature brain perfusion apparatus according to claim 3, wherein the first and second flow dividing plates have a V-shaped cross section, and rounded tips of the first and second flow dividing plates.

5. The brain low-temperature perfusion apparatus according to claim 3, wherein the drainage component further includes two first flow guide strips fixedly connected to one side of the fixing plate close to the inner wall of the liquid storage tank, one side of the two first flow guide strips close to each other is fixedly connected with a plurality of staggered second flow guide strips, flow guide slopes are respectively formed at the tops of the second flow guide strips, the width of the liquid guide port is smaller than the distance between the two first flow guide strips, and the bottom of the liquid guide port is lower than the tops of the first flow guide strips.

6. The low-temperature brain perfusion apparatus according to claim 3, wherein a plurality of second clamping blocks, the number of which is matched with that of the fixing plates, are fixedly connected to the bottom of the shunting plate, and the second clamping blocks abut against the top of the fixing plates.

7. The low-temperature brain perfusion apparatus according to claim 3, wherein the shunting plate is provided with a plurality of grooves adapted to the inner side of the second shunting plate, the bottom of the shunting plate is fixedly connected with a connecting frame, the connecting frame is fixedly connected with a liquid level sensor and a water temperature sensor, and the liquid storage tank is further provided with a monitoring sensor module for detecting the state of blood flowing back to the patient through the liquid injection pipe.

8. The low-temperature brain perfusion apparatus according to claim 1, wherein two first limiting ribs adapted to the semiconductor refrigerating sheet are fixedly connected to an inner side of the limiting frame, the first limiting ribs penetrate through the limiting frame, clamping grooves are formed in two end portions of the limiting frame, a limiting strip adapted to the clamping grooves is clamped on the limiting frame, two second limiting ribs adapted to the side edge of the semiconductor refrigerating sheet are fixedly connected to the limiting strip, a first clamping block is fixedly connected to a bottom of the limiting strip, a pull plate is fixedly connected to a top of the limiting strip, and a wire slot is formed in the limiting frame.

9. The low-temperature brain perfusion apparatus according to claim 1, wherein a plurality of sets of limiting angles adapted to the shape of the thermal pad are fixedly connected to the side wall of the liquid storage tank, each set of limiting angles includes four limiting angles, and the four limiting angles are respectively adapted to four corners of the thermal pad.

10. The low-temperature brain perfusion apparatus according to claim 7, wherein a control panel is further installed on the perfusion apparatus main body, a control unit is disposed on the control panel, and the control unit is electrically connected to the semiconductor refrigeration sheet, the first three-way electromagnetic valve, the first pump body, the second three-way electromagnetic valve, the second pump body, the monitoring sensor module, the third pump body, the body temperature sensor, the servo motor, the liquid level sensor, and the water temperature sensor.