CN115919509A - Heart valve steady-state flow testing system - Google Patents
Heart valve steady-state flow testing system Download PDFInfo
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- CN115919509A CN115919509A CN202310145512.6A CN202310145512A CN115919509A CN 115919509 A CN115919509 A CN 115919509A CN 202310145512 A CN202310145512 A CN 202310145512A CN 115919509 A CN115919509 A CN 115919509A
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- 210000003709 heart valve Anatomy 0.000 title claims abstract description 106
- 238000012360 testing method Methods 0.000 title claims abstract description 82
- 239000012530 fluid Substances 0.000 claims abstract description 41
- 230000008439 repair process Effects 0.000 claims abstract description 32
- 238000005259 measurement Methods 0.000 claims abstract description 31
- 238000005086 pumping Methods 0.000 claims abstract description 29
- 238000009530 blood pressure measurement Methods 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 238000000338 in vitro Methods 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 210000003540 papillary muscle Anatomy 0.000 claims description 5
- 210000003698 chordae tendineae Anatomy 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims 5
- 238000013461 design Methods 0.000 abstract description 6
- 238000010586 diagram Methods 0.000 description 8
- 206010067171 Regurgitation Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 3
- 206010067660 Heart valve incompetence Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000001765 aortic valve Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004115 mitral valve Anatomy 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 210000003102 pulmonary valve Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000000591 tricuspid valve Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
Abstract
The invention provides a heart valve steady-state flow testing system, which comprises: the measuring unit comprises a flow measuring module, a first differential pressure measuring module and a second differential pressure measuring module; the pipeline system is sequentially connected with a pumping module, an in vitro heart valve, a calibration standard nozzle, a flow measurement module and a fluid storage module in series, the pumping module extracts test liquid in the fluid storage module and pumps the test liquid so that the test liquid returns to the fluid storage module after flowing through the in vitro heart valve, the calibration standard nozzle and the flow measurement module in sequence; the first differential pressure measurement module of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module is connected in parallel at two ends of the calibration standard nozzle. The invention can measure the data of the pressure difference and the backflow leakage amount of the isolated heart valve, can also test and calibrate the pressure difference and the backflow leakage amount of the standard nozzle, and provides a near-real test data support for the design of a valve repair instrument.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a heart valve steady-state flow testing system.
Background
When blood flows through the heart valve, a certain pressure difference across the valve is generated, and a certain amount of regurgitation leakage is caused when the valve is closed, so that the characteristics of the artificial heart valve in hemodynamics need to be known by how to reasonably design the artificial heart valve. In the prior art, two schemes of a heart valve repair instrument or a replacement instrument are commonly adopted for solving the problem of the backflow leakage of the heart valve. The biggest difference between the former and the latter is that the repair device is applied to the native valve tissue, i.e. the valve leaflets or valve annulus are clamped by mechanical structure on the basis of the native valve tissue, without replacing the native valve tissue. Therefore, it is important to measure the effectiveness of the prosthetic device in heart valve repair. In the prior art, no steady-state flow testing system related to heart valve repair devices exists; and the repairing effect of the repairing instrument cannot be compared.
Disclosure of Invention
To overcome at least one of the problems in the related art, the present invention provides a heart valve steady-state flow testing system.
The test system comprises:
a system of pipes is provided, which is provided with a plurality of pipes,
the device comprises a measuring unit, a control unit and a control unit, wherein the measuring unit comprises a flow measuring module, a first differential pressure measuring module and a second differential pressure measuring module;
the pipeline system is sequentially connected with a pumping module, an in-vitro heart valve, a calibration standard nozzle, a flow measurement module and a fluid storage module in series, the pumping module extracts test liquid in the fluid storage module and pumps the test liquid so that the test liquid returns to the fluid storage module after flowing through the in-vitro heart valve, the calibration standard nozzle and the flow measurement module in sequence;
the first differential pressure measurement module of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module is connected in parallel at two ends of the calibration standard nozzle.
In an optional embodiment, a buffer device is further arranged on the pipeline between the pumping module and the isolated heart valve, and a plurality of through holes are formed in the buffer device.
In an optional embodiment, the isolated heart valve is connected in the pipeline system through a mounting bracket, two ends of the mounting bracket are respectively abutted to corresponding pipeline end faces, and the isolated heart valve is mounted in the mounting bracket.
In an optional embodiment, the mounting bracket includes a first fixing seat and a second fixing seat, one of the first fixing seat and the second fixing seat is provided with an annular protrusion, the other one of the first fixing seat and the second fixing seat is provided with a groove matched with the annular protrusion, the isolated heart valve is mounted between the protrusion and the groove, and a fluid channel formed by the isolated heart valve extends along the pipeline system.
In an optional embodiment, sealing rings are disposed on end surfaces of the first fixing seat and the second fixing seat respectively facing the pipeline, and the sealing rings are used for sealing a gap between the mounting bracket and the pipeline.
In an optional embodiment, the mounting bracket further comprises a first nut, a second nut, a third nut and a bolt, one end of the bolt passes through the through hole on the mounting bracket and is locked with the mounting bracket through the first nut, the other end of the bolt is provided with the second nut and the third nut, and the second nut and the third nut are used for fixing papillary muscles and/or chordae tendinae of the isolated heart valve.
In an alternative embodiment, after the ex vivo heart valve test is completed, a repair device is installed on the ex vivo heart valve to verify the repair effect of the repair device on the regurgitation of the heart valve.
In an optional embodiment, at least one evacuation module is disposed on the pipeline system, and the evacuation module is connected to the gas extraction module to evacuate gas in the pipeline system.
In an alternative embodiment, the evacuation module may be switched between an open state and a closed state, and the evacuation module is switched to the closed state after the gas in the piping system is evacuated.
In an optional embodiment, the test system further comprises a control module electrically connected to at least one of the pumping module, the flow measurement module, the first differential pressure measurement module, and the second differential pressure measurement module.
The technical scheme of the invention has the following advantages or beneficial effects:
(1) The pipeline system is sequentially connected with a pumping module, an isolated heart valve, a calibration standard nozzle, a flow measurement module and a fluid storage module in series, wherein the pumping module extracts and pumps test liquid in the fluid storage module, so that the test liquid returns to the fluid storage module after sequentially flowing through the isolated heart valve, the calibration standard nozzle and the flow measurement module; the first differential pressure measurement module of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module is connected in parallel at two ends of the calibration standard nozzle; the structure enables the testing system of the invention to synchronously measure the pressure difference and the backflow leakage rate of the isolated heart valve and calibrate the pressure difference and the leakage flow rate of the standard nozzle; and calibrating the standard nozzle serves a comparative function by obtaining the differential pressure of the standard nozzle to calculate an acceptable accuracy tolerance. The data measurement through calibration standard nozzle can ensure that the test data of the pressure difference and the backflow leakage amount of the isolated heart valve is reasonable and reliable, and provides the close to real test data support for the design of valve repair equipment.
(2) Arranging a buffer device on a pipeline between a pumping module and an isolated heart valve, wherein the buffer device is provided with a plurality of through holes; the fluid uniformity in the pipeline can be improved, the simulation effect is more fit with the actual blood flowing process, and the measured backflow leakage amount and pressure difference data are more fit with the real situation.
(3) The mounting bracket comprises a first fixing seat and a second fixing seat, one of the first fixing seat and the second fixing seat is provided with an annular bulge, the other one of the first fixing seat and the second fixing seat is provided with a groove matched with the annular bulge, and the in-vitro heart valve is mounted between the bulge and the groove; the groove and the bulge structure ensure that the isolated heart valve can be firmly fixed on the mounting bracket, and can be kept on the mounting bracket without being taken out even though the repaired device is acted by external force; the complex fitting surface that concave-convex structure formed has guaranteed the leakproofness for test solution can not leak away from the fitting surface between first fixing base and the second fixing base.
(4) The in-vitro heart valve can be further provided with a repair instrument, after the instrument is installed, the in-vitro heart valve is installed in an installation support, then the combined body is installed in a pipeline system, and a pumping module is started to simulate backflow leakage of the heart valve, so that whether the designed repair instrument meets the use requirement or not is verified; therefore, ideal test conditions are provided for the design of the repair instrument, and the reliability of the design of the repair instrument is improved.
Drawings
The drawings are included to provide a better understanding of the invention and are not to be construed as unduly limiting the invention. Wherein:
FIG. 1 is a schematic diagram of a heart valve steady-state flow testing system according to an embodiment of the present invention;
FIG. 2 is an exploded schematic view of a heart valve mounting bracket according to an embodiment of the invention;
FIG. 3 is a schematic view of a heart valve mounted to a mounting bracket according to an embodiment of the invention;
FIG. 4 is a schematic view of a water pump according to an embodiment of the invention;
FIG. 5 is a schematic view of a piping structure of a piping system according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of a flow measurement module according to an embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a fluid storage module according to an embodiment of the invention;
FIG. 8 is a schematic structural diagram of a buffer module according to an embodiment of the present invention;
FIG. 9 is a schematic illustration of a longitudinal cross-section of a cushion module according to an embodiment of the invention;
FIG. 10 is a schematic assembly diagram of an evacuation module and a differential pressure measurement module according to an embodiment of the invention;
FIG. 11 is a schematic diagram of a calibrated standard nozzle, according to an embodiment of the present invention;
FIG. 12 isbase:Sub>A schematic cross-sectional view of the A-A position ofbase:Sub>A calibrated standard nozzle in accordance with an embodiment of the present invention;
FIG. 13 is a schematic structural diagram of an evacuation module according to an embodiment of the invention;
FIG. 14 is a schematic illustration of an evacuation process according to an embodiment of the invention;
FIG. 15 is a schematic view of evacuation completion according to an embodiment of the present invention;
FIG. 16 is an exploded view of a prosthetic device according to an embodiment of the invention mounted to a heart valve;
FIG. 17 is a schematic diagram of a physical connection of a test system according to an embodiment of the present invention;
FIG. 18 is a partially schematic cross-sectional view of a physical connection of a test system according to an embodiment of the invention.
Detailed Description
Exemplary embodiments of the present invention are described below with reference to the accompanying drawings, in which various details of embodiments of the invention are included to assist understanding, and which are to be considered as merely exemplary. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the invention. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
It is to be understood that although the terms first, second, third, etc. may be used herein to describe various information, such information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present application. The word "if" as used herein may be interpreted as "at" \8230; "or" when 8230; \8230; "or" in response to a determination ", depending on the context.
Heart valve regurgitation leakage is one of the major conditions of heart disease. Two methods of valve replacement and valve repair are commonly used in the prior art for treatment. For the latter, how to determine the heart valve regurgitation parameters and how to evaluate the repairing effect of the repairing device after implantation are key indicators to be considered by designers. Therefore, how to systematically and accurately evaluate the backflow leakage amount of the heart valve and the repair effect of the repair instrument is a core problem to be solved by the invention. To this end, the invention proposes a heart valve steady-state flow testing system comprising: the system comprises a pipeline system and a measuring unit, wherein the measuring unit comprises a flow measuring module, a first differential pressure measuring module and a second differential pressure measuring module; the pipeline system is sequentially connected with a pumping module, an in-vitro heart valve, a calibration standard nozzle, a flow measurement module and a fluid storage module in series, the pumping module extracts test liquid in the fluid storage module and pumps the test liquid so that the test liquid returns to the fluid storage module after flowing through the in-vitro heart valve, the calibration standard nozzle and the flow measurement module in sequence; the first differential pressure measurement module of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module is connected in parallel at two ends of the calibration standard nozzle.
In the embodiment shown in fig. 1, a heart valve steady-state flow testing system is illustratively shown. The testing system mainly comprises a pipeline system and a measuring unit. The measuring unit comprises a flow measuring module, a first differential pressure measuring module and a second differential pressure measuring module. The flow measurement module is used for measuring the flow in the pipeline system under the valve backflow state, and the flow is used for reflecting the leakage amount flowing through the isolated valve under the backflow state. For example, the flow measurement module may be a flow meter, etc., and this is only an example and does not limit the scope of the present invention. The first differential pressure measuring module and the second differential pressure measuring module are used for measuring the differential pressure of the fluid on the upstream and the downstream of the element to be measured. As shown in fig. 1, the pipeline system is formed by splicing a plurality of test channels (or called pipelines), and the end face of each test pipeline is provided with a flange end face to facilitate connection with each other or other elements. Specifically, as shown in the example of fig. 1, the pipeline system includes a test channel No. 1 104, a test channel No. 2 105, a test channel No. 3 106, a test channel No. 4 107, a test channel No. 5 108, a test channel No. 4 107, a test channel No. 6 111, and a test channel No. 7, which are connected in sequence. In addition, the pipeline system is also sequentially connected with the pumping module 101, the isolated heart valve 205, the calibration standard nozzle 115, the flow measurement module 114 and the fluid storage module 113 in series. The sequential series connection refers to that the elements are connected in series through pipelines or test channels. During operation, the pumping module 101 extracts and pumps the test liquid in the fluid storage module 113, so that the test liquid sequentially flows through the isolated heart valve, the calibration standard nozzle and the flow measurement module and then returns to the fluid storage module. In practice, the pumping module 101 may be selected as a water pump, which is a name only and can pump a plurality of fluids, such as test fluids used in the test of the present invention. Fig. 4 illustrates a conventional water pump 301 having two ports, each port having a conduit 302 and a conduit 303 connected thereto, the conduit 302 being connected to the fluid storage module described above, and the conduit 303 being connected to test channel No. 1. The isolated heart valve can be a heart valve of an animal body. The fluid storage module 113 may be selected as a reservoir container. The reservoir may take a variety of configurations, such as the rectangular parallelepiped configuration shown in fig. 7. In the embodiment shown in fig. 1, 17, and 18, the fluid pumped by the pumping module into the isolated heart valve can simulate the regurgitation flow process of the isolated heart valve. The calibrated standard nozzles are used to calculate acceptable accuracy tolerances that are required to be used with the flow measurement module and the differential pressure measurement module, as described in detail below. The first differential pressure measurement module 118 of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module 116 is connected in parallel at two ends of the calibration standard nozzle. The backflow leakage amount of the isolated heart valve and the flow rate flowing through the calibrated standard nozzle are monitored by installing a flow measurement module in the pipeline system. The first pressure difference measuring unit is used for measuring the pressure difference of the test fluid before and after crossing the isolated heart valve, and the pressure difference reflects the pressure difference before and after the isolated heart valve; the second differential pressure measurement unit is used for measuring the differential pressure of the test fluid across the front and the back of the standard calibration nozzle, and the differential pressure reflects the front and the back differential pressure of the standard calibration nozzle. In the example shown in fig. 5 and 10, an assembly drawing of the differential pressure measurement unit is shown. The pipeline of the pipeline system is provided with a differential pressure connection hole 402, a differential pressure connector 1004 is installed in the differential pressure connection hole 402, the other connector of the differential pressure connector 1004 is used for connecting a differential pressure measurement unit, and the differential pressure measurement unit can be a pressure sensor 1003. In one implementation, in order to reduce the processing difficulty of the pipeline, the through holes arranged on the pipeline of the pipeline system are all used for connecting the emptying module, and the differential pressure measurement unit is connected through the interface on the emptying module. The mode not only reduces the processing difficulty of the pipeline, but also is convenient for flexibly adjusting the number of the emptying modules in the emptying process, and is more convenient for connecting the differential pressure measuring unit. In the embodiment shown in fig. 11 and 12, the calibration standard nozzle is a disk structure, and a through hole is formed in the center of the disk structure; and the through hole has a tapered structure, namely the sectional area of the inlet of the fluid is larger than that of the outlet, so that the fluid is accelerated by the standard calibration nozzle and then is sprayed out in a spraying state. Through the testing system, the pressure difference and the backflow leakage rate of the isolated heart valve can be synchronously measured, and the pressure difference and the leakage flow rate of the standard nozzle can be calibrated. It should be noted that the calibration of the standard nozzle herein is used for comparison purposes, specifically to obtain the differential pressure of the standard nozzle to calculate acceptable accuracy tolerances. Furthermore, a pressure-leakage curve of the standard calibration nozzle is obtained, and the curve is compared with the gradient of the industry standard backflow nozzle to judge whether the test data is reasonable and reliable, so that the test data of the pressure difference and the backflow leakage of the isolated heart valve are reasonable and reliable. Therefore, the technical scheme disclosed by the embodiment of the invention can measure the isolated heart valve data, can monitor the reliability of the measured data, and provides a near-real test data support for the design of the valve repair instrument.
In an optional embodiment, a buffer device is further arranged on the pipeline between the pumping module and the isolated heart valve, and a plurality of through holes are formed in the buffer device. As in the examples shown in fig. 1, 8 and 9, a cushioning device 102 is also connected between the pumping module and the isolated heart valve. The buffer device 102 comprises a pipeline part 801 and a through hole 802 arranged in the pipeline part 801, wherein the through hole 802 extends along the axis of the buffer device 102 and penetrates through the buffer device to form a flow passage. In one embodiment, the through holes 802 are provided in a plurality and uniformly distributed along the end surface of the pipe portion 801. In use, because the pressure of the fluid pumped by the pumping device is high, and the flow rate, the pressure and the like are not uniformly distributed along the pipeline, if the fluid pumped by the pumping device is directly sent to the isolated heart valve, the pressure intensity of the fluid received by the isolated heart valve is not uniformly distributed, and the accuracy of the measurement result is influenced. Therefore, after the buffering device is arranged, the flow speed and the pressure difference of fluid passing through the through holes are reduced, the flow speed and the pressure of the outlet end of each through hole are basically equal, the water flow is more linear, and the simulation result of the test system is more consistent with the real situation.
In an optional embodiment, the isolated heart valve is connected in the pipeline system through a mounting bracket, two ends of the mounting bracket are respectively abutted to corresponding pipeline end surfaces, and the isolated heart valve is mounted in the mounting bracket. In the embodiment shown in fig. 1 and 3, the isolated heart valve 205 is shown attached to a conduit by a mounting bracket 103. Because the isolated heart valve has a certain flexibility, it is difficult to directly mount the isolated heart valve on the connecting end surface of the tube, for example, on the mating surface between the test tube No. 2 105 and the test tube No. 3 106 shown in fig. 1. Furthermore, even if it is forcibly attached to the mating surface, there is a greater or lesser amount of fluid leakage that affects the safety of the test device and the accuracy of the measurement. To this end, in one embodiment of the present invention, a mounting bracket is provided as shown in fig. 2 and 3, wherein the mounting bracket provides a structure for clamping or fixing the isolated heart valve, and when the isolated heart valve is mounted on the mounting bracket, the assembly of the two can be mounted on the matching surface. It will be appreciated that the mounting bracket may be pre-designed with a connection interface that mates with the end face of the test tube.
In an optional embodiment, the mounting bracket includes a first fixing seat and a second fixing seat, one of the first fixing seat and the second fixing seat is provided with an annular protrusion, the other one of the first fixing seat and the second fixing seat is provided with a groove matched with the annular protrusion, the isolated heart valve is mounted between the protrusion and the groove, and a fluid channel formed by the isolated heart valve extends along the pipeline system. In the embodiment shown in fig. 2 and 3, the mounting bracket includes a first fixing base 202 and a second fixing base 204, and the two fixing bases may be made of Acrylonitrile-Butadiene-Styrene (ABS), polycarbonate (PC), polystyrene (PS), and the like. The relative terminal surface of first fixing base and second fixing base on be provided with annular protrusion and annular groove, when first fixing base and second fixing base assembly together, protrusion and recess can the card be in the same place. When assembling an isolated heart valve, the edges of the valve can be crimped between the protrusions and recesses. The groove and the bulge structure ensure that the isolated heart valve can be firmly fixed on the mounting bracket, and can be kept on the mounting bracket without being carried out even after being acted by an external force by a repair device. Therefore, when the repair effect of the repair device is verified subsequently, an operator can easily install the repair device on the isolated heart valve without considering whether the heart valve is separated from the installation space. Moreover, the complex fitting surface that concave-convex structure formed has guaranteed the leakproofness for test solution can not leak away from the fitting surface between first fixing base and the second fixing base. After clamping the isolated heart valve on the mounting bracket, the flow passage formed by the isolated heart valve extends along the fluid flow direction 109 of the pipeline, so that the fluid pumped by the pumping module can be ensured to be reversely delivered to the isolated heart valve to simulate the backflow leakage phenomenon. In the experiment, the isolated heart valve can be a tricuspid valve, a mitral valve, an aortic valve, a pulmonary valve and the like.
In an optional embodiment, sealing rings are disposed on end surfaces of the first fixing seat and the second fixing seat respectively facing the pipeline, and the sealing rings are used for sealing a gap between the mounting bracket and the pipeline. In the embodiment shown in fig. 2, the first fixing seat and the second fixing seat are respectively provided with a sealing member mounting portion at a portion facing the end surface of the pipeline, and the sealing members may be a left sealing ring 201 and a right sealing ring 203. When the mounting bracket is mounted with the pipeline in a matching way, the end face of the pipeline and the mounting bracket jointly extrude the sealing element and deform the sealing element to generate a sealing effect.
In an optional embodiment, the mounting bracket further comprises a first nut, a second nut, a third nut and a bolt, one end of the bolt passes through the through hole on the mounting bracket and is locked with the mounting bracket through the first nut, the other end of the bolt is provided with the second nut and the third nut, and the second nut and the third nut are used for fixing papillary muscles and/or chordae tendineae of the isolated heart valve. In the embodiment shown in fig. 3, the mounting bracket further comprises a plurality of nuts and bolts 211, wherein the nuts include a first nut 206, a second nut 207, and a third nut 209. The bolts and the nuts comprise three groups, one bolt in each group is provided with the first nut, the second nut and the third nut, and the second nut and the third nut are positioned at the end part of the screw rod far away from the mounting bracket main body. The second nut and the third nut are arranged at intervals and are used for fixing papillary muscles and/or chordae tendineae 210 of the isolated heart valve. In particular, the papillary muscles and/or chordae tendineae may be packed in the gap between the first nut and the second nut and then secured in the gap with the securing element. As shown in fig. 3, it is secured with a tie 208. The other end of the screw is fixed to the mounting bracket by a first nut 206. Specifically, three through holes may be provided in the mounting bracket, and after the bolt is inserted into the through hole, the screw and the mounting bracket are locked together by the first nut 206.
In an alternative embodiment, after the ex vivo heart valve test is completed, a repair device is installed on the ex vivo heart valve to verify the repair effect of the repair device on the regurgitation of the heart valve. As shown in fig. 16, a repair device 1601 may be further mounted on the isolated heart valve, after the device is mounted, the isolated heart valve is mounted in the mounting bracket, and then the combined body is mounted in the pipeline system, and the pumping module is started to simulate the backflow leakage of the heart valve, so as to verify whether the designed repair device meets the use requirements. During specific operation, the repair effect can be confirmed by collecting test data of the isolated heart valve with the repair instrument installed, such as pressure difference and leakage amount data, and comparing the test data with the test data without the repair instrument installed.
In an optional embodiment, at least one evacuation module is disposed on the pipeline system, and the evacuation module is connected to the gas extraction module to evacuate gas in the pipeline system. In an alternative embodiment, the evacuation module may be switched between an open state and a closed state, and the evacuation module is switched to the closed state after the gas in the piping system is evacuated. In practice, the tubing system needs to be evacuated of gas before the test device is turned on in order to restore the blood flow as much as possible. In particular, an evacuation module may be provided on the pipe system. It will be appreciated that when a plurality of evacuation modules are provided, evacuation can be performed from different locations for the piping system, increasing the efficiency of the evacuation operation. In the embodiment shown in fig. 17, each pipe in the pipe system is provided with an evacuation connection hole and connected to a corresponding evacuation module. As shown in fig. 5 and 10, it is shown how an evacuation valve connection hole 401 is provided in the pipe to perform an evacuation operation on the length of pipe. Specifically, an evacuation module such as an evacuation valve 1002 may be mounted on the connection hole 401, and then an air-extracting module may be connected to the connection hole of the evacuation module. In one embodiment, an injector is used to evacuate the gas in the conduit. For example, referring to the embodiment shown in fig. 14 and 15, when the syringe 1001 is connected to the connection port 1402 of the purge module, the operating handle 1403 (or called OFF flag) of the purge module is placed in an open state, such as the vertical position shown in fig. 14, and then the plunger 1401 of the syringe is pulled to drive the fluid flow in the tubing, the gas 1405 will leave the tubing as the plunger moves and enter the injection session. If the gas in the pipeline is more, the operation can be repeatedly executed until the gas in the pipeline is completely discharged. After the evacuation operation is completed, the operating handle of the evacuation module can be placed in a closed state, such as the horizontal state shown in fig. 15.
In an optional embodiment, the test system further comprises a control module electrically connected to at least one of the pumping module, the flow measurement module, the first differential pressure measurement module, and the second differential pressure measurement module. In order to improve the automation degree of the test system and collect and store corresponding data in real time for various data analyses, in one example, a control module 1701 is further integrated into the test system, and the control module may be provided with a data collection card to collect data measured by various measurement modules, for example, the control module is respectively connected with a flow measurement module, a first differential pressure measurement module and a second differential pressure measurement module to collect flow and differential pressure data in real time; alternatively, the control module may be electrically connected to the pumping module for remotely controlling the pumping module to be remotely turned on or off.
The above-described embodiments should not be construed as limiting the scope of the invention. Other embodiments of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure disclosed herein. This application is intended to cover any variations, uses, or adaptations of the disclosure following, in general, the principles of the disclosure and including such departures from the present disclosure as come within known or customary practice within the art to which the disclosure pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the disclosure being indicated by the following claims.
It will be understood that the present disclosure is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The scope of the present disclosure is limited only by the appended claims.
Claims (10)
1. A heart valve steady-state flow testing system, comprising:
a system of pipes is provided, which is provided with a plurality of pipes,
the device comprises a measuring unit, a control unit and a control unit, wherein the measuring unit comprises a flow measuring module, a first differential pressure measuring module and a second differential pressure measuring module;
the method is characterized in that:
the pipeline system is sequentially connected with a pumping module, an in-vitro heart valve, a calibration standard nozzle, a flow measurement module and a fluid storage module in series, the pumping module extracts test liquid in the fluid storage module and pumps the test liquid so that the test liquid returns to the fluid storage module after flowing through the in-vitro heart valve, the calibration standard nozzle and the flow measurement module in sequence;
the first differential pressure measurement module of the measurement unit is connected in parallel at two ends of the isolated heart valve, and the second differential pressure measurement module is connected in parallel at two ends of the calibration standard nozzle.
2. The test system of claim 1,
the pipeline between the pumping module and the isolated heart valve is also provided with a buffer device, and the buffer device is provided with a plurality of through holes.
3. The test system of claim 1,
the heart valve separation device is characterized in that the heart valve separation device is connected in a pipeline system through a mounting support, two ends of the mounting support are respectively abutted against corresponding pipeline end faces, and the heart valve separation device is mounted in the mounting support.
4. The test system of claim 3,
the installing support include first fixing base and second fixing base, first fixing base and second fixing base on be provided with annular protrusion, be provided with on the other with annular protrusion complex recess, separation heart valve install between arch and the recess, and the fluid passage that separation heart valve formed follows pipe-line system extend.
5. The test system of claim 4,
the first fixing seat and the second fixing seat are respectively provided with a sealing ring on the end faces facing the pipeline, and the sealing rings are used for sealing a gap between the mounting support and the pipeline.
6. The test system of claim 3,
the mounting bracket further comprises a first nut, a second nut, a third nut and a bolt, one end of the bolt penetrates through a through hole in the mounting bracket and is locked with the mounting bracket through the first nut, the second nut and the third nut are mounted at the other end of the bolt, and the second nut and the third nut are used for fixing papillary muscles and/or chordae tendineae of the isolated heart valve.
7. The test system of claim 1,
after the isolated heart valve test is completed, a repair instrument is installed on the isolated heart valve to verify the repair effect of the repair instrument on the backflow of the heart valve.
8. The test system of claim 1,
the pipeline system is provided with at least one evacuation module, and the evacuation module is connected with the air extraction module to evacuate gas in the pipeline system.
9. The test system of claim 8,
the evacuation module can be switched between an open state and a closed state, and after gas in the pipeline system is evacuated, the evacuation module is switched to the closed state.
10. The test system of claim 1,
the test system further comprises a control module electrically connected with at least one of the pumping module, the flow measurement module, the first differential pressure measurement module and the second differential pressure measurement module.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310145512.6A CN115919509A (en) | 2023-02-22 | 2023-02-22 | Heart valve steady-state flow testing system |
| CN202321651446.1U CN220293713U (en) | 2023-02-22 | 2023-06-28 | Heart valve steady-state flow test system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310145512.6A CN115919509A (en) | 2023-02-22 | 2023-02-22 | Heart valve steady-state flow testing system |
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| Publication Number | Publication Date |
|---|---|
| CN115919509A true CN115919509A (en) | 2023-04-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310145512.6A Pending CN115919509A (en) | 2023-02-22 | 2023-02-22 | Heart valve steady-state flow testing system |
| CN202321651446.1U Active CN220293713U (en) | 2023-02-22 | 2023-06-28 | Heart valve steady-state flow test system |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202321651446.1U Active CN220293713U (en) | 2023-02-22 | 2023-06-28 | Heart valve steady-state flow test system |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495049A (en) * | 2005-01-21 | 2009-07-29 | 梅约医学教育与研究基金会 | Thorascopic heart valve repair method and apparatus |
| CN101902975A (en) * | 2007-10-18 | 2010-12-01 | 尼奥绰德有限公司 | Minimally invasive repair of a valve leaflet in a beating heart |
| CN111437069A (en) * | 2020-04-26 | 2020-07-24 | 科凯(南通)生命科学有限公司 | Heart valve flow performance detection device |
| CN114533346A (en) * | 2022-02-15 | 2022-05-27 | 上海盈阁智能科技有限公司 | Valve steady-state flow performance testing system and method |
-
2023
- 2023-02-22 CN CN202310145512.6A patent/CN115919509A/en active Pending
- 2023-06-28 CN CN202321651446.1U patent/CN220293713U/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495049A (en) * | 2005-01-21 | 2009-07-29 | 梅约医学教育与研究基金会 | Thorascopic heart valve repair method and apparatus |
| CN101902975A (en) * | 2007-10-18 | 2010-12-01 | 尼奥绰德有限公司 | Minimally invasive repair of a valve leaflet in a beating heart |
| CN111437069A (en) * | 2020-04-26 | 2020-07-24 | 科凯(南通)生命科学有限公司 | Heart valve flow performance detection device |
| CN114533346A (en) * | 2022-02-15 | 2022-05-27 | 上海盈阁智能科技有限公司 | Valve steady-state flow performance testing system and method |
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|---|---|
| CN220293713U (en) | 2024-01-05 |
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Application publication date: 20230407 |