CN115918671A - Insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned aerial defense - Google Patents

Insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned aerial defense Download PDF

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Publication number
CN115918671A
CN115918671A CN202211302296.3A CN202211302296A CN115918671A CN 115918671 A CN115918671 A CN 115918671A CN 202211302296 A CN202211302296 A CN 202211302296A CN 115918671 A CN115918671 A CN 115918671A
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cyfluthrin
stirring
insecticidal
constant speed
weight ratio
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祝春华
朱永杰
李献
李伟
王战
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Chitianhua Technology Group Co ltd
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Chitianhua Technology Group Co ltd
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to an imidacloprid and cyfluthrin-containing insecticidal composition suitable for unmanned flying prevention, which comprises the following raw materials in parts by weight: 3-10 parts of insecticidal factor, 1-10 parts of imidacloprid and 1-5 parts of cyfluthrin; the insecticidal factor can be made into aqua, granules, suspending agent, wettable powder and microemulsion according to actual requirements, the insecticidal factor directly acts on acetylcholine receptors of insects to generate toxic action on organisms of the insects, and generates stomach toxicity on the insects to effectively kill lepidoptera, diptera and other pests, and the insecticidal factor does not generate drug mutual resistance with imidacloprid and cyfluthrin, can be used in a synergistic manner to enhance the insecticidal effect.

Description

Insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned aerial defense
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to an insecticidal composition containing imidacloprid and cyfluthrin, which is suitable for unmanned aerial defense.
Background
Chemical control is an important means of preventing and controlling pests in agriculture. However, currently, there are cases where effective control cannot be achieved due to the type of pest, living characteristics, living environment, and the like, which are poor in effect, developed in resistance, and the like. In particular, it is becoming increasingly difficult to control lepidopteran, coleopteran, homopteran, and thysanopteran pests using conventional agents.
Imidacloprid is a nitro methylene systemic insecticide, belonging to chloronicotinyl insecticides, also known as neonicotinyl insecticides. The pesticide has the characteristics of broad spectrum, high efficiency, low toxicity and low residue, is not easy to generate resistance by pests, and has multiple effects of contact poisoning, stomach toxicity, systemic absorption and the like;
cyfluthrin, also known as cyfluthrin, cyfluthrin and permethrin, is an organic substance with a chemical formula of C 22 H 18 Cl 2 FNO 3 A viscous, partially crystalline amber oil.
However, in order to improve the insecticidal effect in the current market, imidacloprid and cyfluthrin are compounded to improve the control effect on insect pests, but the actual discovery shows that the compound imidacloprid and cyfluthrin have limited improvement degree on the final insecticidal effect and do not make great breakthrough.
Disclosure of Invention
In order to solve the problems, the invention aims to provide an insecticidal composition containing imidacloprid and cyfluthrin, which is suitable for unmanned flight control.
The purpose of the invention can be realized by the following technical scheme:
the insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned flying prevention comprises the following raw materials in parts by weight: 3-10 parts of insecticidal factor, 1-10 parts of imidacloprid and 1-5 parts of cyfluthrin;
the insecticidal factor is prepared by the following steps:
step S1, adding calcium cyanamide into deionized water, stirring at a constant speed for 10min, adding a potassium hydroxide aqueous solution with the mass fraction of 20% and polyethylene glycol 400, maintaining the reaction temperature at 0-10 ℃, stirring at a constant speed, slowly dropwise adding carbon disulfide, heating to 45 ℃ after dropwise addition, continuously stirring for 6h, filtering while hot to obtain a product, performing rotary evaporation until water is removed, washing with absolute ethyl alcohol for three times, and drying to obtain an intermediate 1, wherein the weight ratio of the calcium cyanamide to the potassium hydroxide aqueous solution to the polyethylene glycol 400 to the carbon disulfide to the deionized water is controlled to be 20: 52.0-52.2: 1.5-1.6: 10.5-12.0: 100;
in the step S1, calcium cyanamide, carbon disulfide and potassium hydroxide react to generate an intermediate 1, and the reaction process is as follows:
s2, adding the intermediate 1 into a mixed solvent, stirring at a constant speed for 30min, sequentially adding zirconium oxide, polyethylene glycol 400 and dimethyl carbonate, heating to 180 ℃, carrying out reflux reaction for 10h, extracting after the reaction is finished, extracting with dichloromethane for three times, combining organic phases collected each time, washing with water and recrystallizing to obtain an intermediate 2, and controlling the weight ratio of the intermediate 1, the zirconium oxide, the polyethylene glycol 400, the dimethyl carbonate and the mixed solvent to be 10: 0.5-0.6: 0.5: 45-50: 50;
in the step S2, the intermediate 1 reacts with dimethyl carbonate in a mixed solvent to generate an intermediate 2, and the reaction process is as follows:
s3, adding the intermediate 2 into ethanol, stirring at a constant speed for 10min at room temperature, slowly dropwise adding the solution a, removing methyl mercaptan in the reaction process, heating to 40 ℃ after dropwise adding, stirring at a constant speed, reacting for 4h, distilling under reduced pressure to remove ethanol, and performing suction filtration to obtain an intermediate 3, wherein the weight ratio of the intermediate 2 to the solution a is 43.5-45: 100-105;
the solution a is formed by mixing 2-aminoethanethiol hydrochloride and a sodium hydroxide aqueous solution with the mass fraction of 15% according to the weight ratio of 1: 2.
In step S3, the intermediate 2 reacts with 2-aminoethanethiol hydrochloride to produce an intermediate 3, the reaction process is as follows:
step S4, adding the intermediate 3 and sodium carbonate into acetonitrile, slowly dropwise adding chloroacetonitrile after stirring at a constant speed for 15min, heating up, refluxing for 4h, cooling to room temperature after the reaction is finished, removing the solvent by rotary evaporation, and performing column chromatography (purifying with V acetic acid: V petroleum ether = 1: 1) to obtain an intermediate 4, wherein the weight ratio of the intermediate 3, the sodium carbonate, the acetonitrile and the chloroacetonitrile is controlled to be 12.5: 12.5-13: 120: 7.5-7.8;
in the step S4, the intermediate 3 reacts with chloroacetonitrile to prepare an intermediate 4, and the reaction process is as follows:
and S5, sequentially adding the intermediate 4 and sodium tert-butoxide into ethanol, slowly adding p-fluorobenzaldehyde dropwise after magnetic stirring for 10min, stirring at a constant speed and reacting for 4h, performing suction filtration after the reaction is finished, and purifying by column chromatography (V acetic acid: V petroleum ether = 1: 1) to prepare the insecticidal factor, wherein the weight ratio of the intermediate 4 to the sodium tert-butoxide to the p-fluorobenzaldehyde to the ethanol is controlled to be 2: 1.3-1.5: 1.6-1.8: 100.
In the step S5, the intermediate 4 reacts with p-fluorobenzaldehyde to prepare the insecticidal factor, and the reaction process is as follows:
the insecticidal factor is prepared by the reaction of the intermediate 4 and p-fluorobenzaldehyde, and structurally, the insecticidal factor is a thiazole derivative containing benzene ring fluorine atoms, and when the insecticidal factor acts on an insect body, the insecticidal factor can directly act on an acetylcholine receptor of the insect to generate a toxic action on the body of the insect, and can generate a stomach toxicity action on the insect to effectively kill pests such as Lepidoptera and Diptera, and the insecticidal factor does not generate drug mutual resistance with imidacloprid and cyfluthrin, so that the insecticidal factor can be used synergistically to enhance the insecticidal effect.
Further: the formulation of the composition is any one of aqueous solution, granules, suspending agent, wettable powder and microemulsion.
Further: the mixed solvent in the step S2 is formed by mixing deionized water, ethylene glycol, dodecyl phenol polyoxyethylene ether and Turkey red oil according to the weight ratio of 10: 1: 0.5.
The invention has the beneficial effects that:
the insecticidal factor is structurally a thiazole derivative containing benzene ring and fluorine atoms, when the insecticidal factor acts on insects, the insecticidal factor can directly act on acetylcholine receptors of the insects to further generate a toxic action on organisms of the insects, and the insecticidal factor has a stomach toxicity effect on the insects to effectively kill lepidoptera, diptera and other pests, and the insecticidal factor does not generate drug mutual resistance with the imidacloprid and cyfluthrin, so that the insecticidal factor can be cooperatively used to enhance the insecticidal effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The insecticidal factor is prepared by the following steps:
step S1, adding calcium cyanamide into deionized water, stirring at a constant speed for 10min, adding a potassium hydroxide aqueous solution with the mass fraction of 20% and polyethylene glycol 400, maintaining the reaction temperature at 0 ℃, stirring at a constant speed, slowly dropwise adding carbon disulfide, heating to 45 ℃ after dropwise addition, continuously stirring for 6h, filtering while hot to obtain a product, performing rotary evaporation until water is removed, washing with absolute ethyl alcohol for three times, and drying to obtain an intermediate 1, wherein the weight ratio of the calcium cyanamide to the potassium hydroxide aqueous solution to the polyethylene glycol 400 to the carbon disulfide to the deionized water is controlled to be 20: 52.0: 1.5: 10.5: 100;
s2, adding the intermediate 1 into a mixed solvent, stirring at a constant speed for 30min, sequentially adding zirconium oxide, polyethylene glycol 400 and dimethyl carbonate, heating to 180 ℃, carrying out reflux reaction for 10h, extracting after the reaction is finished, extracting with dichloromethane for three times, combining organic phases collected each time, washing with water and recrystallizing to obtain an intermediate 2, and controlling the weight ratio of the intermediate 1, the zirconium oxide, the polyethylene glycol 400, the dimethyl carbonate and the mixed solvent to be 10: 0.5: 45: 50;
the mixed solvent is formed by mixing deionized water, ethylene glycol, dodecyl phenol polyoxyethylene ether and Turkey red oil according to the weight ratio of 10: 1: 0.5.
S3, adding the intermediate 2 into ethanol, stirring at a constant speed for 10min at room temperature, slowly dropwise adding the solution a, removing methyl mercaptan in the reaction process, heating to 40 ℃ after dropwise adding, stirring at a constant speed, reacting for 4h, distilling under reduced pressure to remove ethanol, and performing suction filtration to obtain an intermediate 3, wherein the weight ratio of the intermediate 2 to the solution a is 43.5: 100;
the solution a is formed by mixing 2-aminoethanethiol hydrochloride and 15 percent sodium hydroxide aqueous solution according to the weight ratio of 1: 2.
Step S4, adding the intermediate 3 and sodium carbonate into acetonitrile, slowly dropwise adding chloroacetonitrile after stirring at a constant speed for 15min, heating up, refluxing for reaction for 4h, cooling to room temperature after the reaction is finished, removing the solvent by rotary evaporation, and performing column chromatography (purifying with V acetic acid: V petroleum ether = 1: 1) to obtain an intermediate 4, wherein the weight ratio of the intermediate 3, the sodium carbonate, the acetonitrile and the chloroacetonitrile is controlled to be 12.5: 120: 7.5;
and S5, sequentially adding the intermediate 4 and sodium tert-butoxide into ethanol, slowly adding p-fluorobenzaldehyde dropwise after magnetically stirring for 10min, stirring at a constant speed and reacting for 4h, performing suction filtration after the reaction is finished, and purifying by column chromatography (V acetic acid: V petroleum ether = 1: 1) to prepare the insecticidal factor, wherein the weight ratio of the intermediate 4 to the sodium tert-butoxide to the p-fluorobenzaldehyde to the ethanol is controlled to be 2: 1.3: 1.6: 100.
Example 2
The insecticidal factor is prepared by the following steps:
step S1, adding calcium cyanamide into deionized water, stirring at a constant speed for 10min, adding a potassium hydroxide aqueous solution with the mass fraction of 20% and polyethylene glycol 400, maintaining the reaction temperature at 10 ℃, stirring at a constant speed, slowly dropwise adding carbon disulfide, heating to 45 ℃ after dropwise addition, continuously stirring for 6h, filtering while hot to obtain a product, performing rotary evaporation until water is removed, washing with absolute ethyl alcohol for three times, and drying to obtain an intermediate 1, wherein the weight ratio of the calcium cyanamide to the potassium hydroxide aqueous solution to the polyethylene glycol 400 to the carbon disulfide to the deionized water is controlled to be 20: 52.1: 1.55: 11: 100;
s2, adding the intermediate 1 into a mixed solvent, stirring at a constant speed for 30min, sequentially adding zirconium oxide, polyethylene glycol 400 and dimethyl carbonate, heating to 180 ℃, carrying out reflux reaction for 10h, extracting after the reaction is finished, extracting with dichloromethane for three times, combining organic phases collected each time, washing with water and recrystallizing to obtain an intermediate 2, and controlling the weight ratio of the intermediate 1, the zirconium oxide, the polyethylene glycol 400, the dimethyl carbonate to the mixed solvent to be 10: 0.55: 0.5: 48: 50;
the mixed solvent is formed by mixing deionized water, ethylene glycol, dodecyl phenol polyoxyethylene ether and Turkey red oil according to the weight ratio of 10: 1: 0.5.
S3, adding the intermediate 2 into ethanol, stirring at a constant speed for 10min at room temperature, slowly dropwise adding the solution a, removing methyl mercaptan in the reaction process, heating to 40 ℃ after dropwise adding, stirring at a constant speed, reacting for 4h, distilling under reduced pressure to remove ethanol, and performing suction filtration to obtain an intermediate 3, wherein the weight ratio of the intermediate 2 to the solution a is 44.5: 102;
the solution a is formed by mixing 2-aminoethanethiol hydrochloride and 15 percent sodium hydroxide aqueous solution according to the weight ratio of 1: 2.
Step S4, adding the intermediate 3 and sodium carbonate into acetonitrile, slowly dropwise adding chloroacetonitrile after stirring at a constant speed for 15min, heating up, refluxing for reaction for 4h, cooling to room temperature after the reaction is finished, removing the solvent by rotary evaporation, and performing column chromatography (purifying with V acetic acid: V petroleum ether = 1: 1) to obtain an intermediate 4, wherein the weight ratio of the intermediate 3, the sodium carbonate, the acetonitrile and the chloroacetonitrile is controlled to be 12.5: 12.8: 120: 7.6;
and S5, sequentially adding the intermediate 4 and sodium tert-butoxide into ethanol, slowly adding p-fluorobenzaldehyde dropwise after magnetically stirring for 10min, stirring at a constant speed and reacting for 4h, performing suction filtration after the reaction is finished, and purifying by column chromatography (V acetic acid: V petroleum ether = 1: 1) to prepare the insecticidal factor, wherein the weight ratio of the intermediate 4 to the sodium tert-butoxide to the p-fluorobenzaldehyde to the ethanol is controlled to be 2: 1.4: 1.7: 100.
Example 3
The insecticidal factor is prepared by the following steps:
step S1, adding calcium cyanamide into deionized water, stirring at a constant speed for 10min, adding a potassium hydroxide aqueous solution with the mass fraction of 20% and polyethylene glycol 400, maintaining the reaction temperature at 10 ℃, stirring at a constant speed, slowly dropwise adding carbon disulfide, heating to 45 ℃ after dropwise addition, continuously stirring for 6h, filtering while hot to obtain a product, performing rotary evaporation until water is removed, washing with absolute ethyl alcohol for three times, and drying to obtain an intermediate 1, wherein the weight ratio of the calcium cyanamide to the potassium hydroxide aqueous solution to the polyethylene glycol 400 to the carbon disulfide to the deionized water is controlled to be 20: 52.2: 1.6: 12.0: 100;
s2, adding the intermediate 1 into a mixed solvent, stirring at a constant speed for 30min, sequentially adding zirconium oxide, polyethylene glycol 400 and dimethyl carbonate, heating to 180 ℃, carrying out reflux reaction for 10h, extracting after the reaction is finished, extracting with dichloromethane for three times, combining organic phases collected each time, washing with water and recrystallizing to obtain an intermediate 2, and controlling the weight ratio of the intermediate 1, the zirconium oxide, the polyethylene glycol 400, the dimethyl carbonate and the mixed solvent to be 10: 0.6: 0.5: 50;
the mixed solvent is formed by mixing deionized water, ethylene glycol, dodecyl phenol polyoxyethylene ether and Turkey red oil according to the weight ratio of 10: 1: 0.5.
S3, adding the intermediate 2 into ethanol, stirring at a constant speed for 10min at room temperature, slowly dropwise adding the solution a, removing methyl mercaptan in the reaction process, heating to 40 ℃ after dropwise adding, stirring at a constant speed, reacting for 4h, distilling under reduced pressure to remove ethanol, and performing suction filtration to obtain an intermediate 3, wherein the weight ratio of the intermediate 2 to the solution a is 45: 105;
the solution a is formed by mixing 2-aminoethanethiol hydrochloride and 15 percent sodium hydroxide aqueous solution according to the weight ratio of 1: 2.
Step S4, adding the intermediate 3 and sodium carbonate into acetonitrile, slowly dropwise adding chloroacetonitrile after stirring at a constant speed for 15min, heating up, refluxing for reaction for 4h, cooling to room temperature after the reaction is finished, removing the solvent by rotary evaporation, and performing column chromatography (purifying with V acetic acid: V petroleum ether = 1: 1) to obtain an intermediate 4, wherein the weight ratio of the intermediate 3, the sodium carbonate, the acetonitrile and the chloroacetonitrile is controlled to be 12.5: 13: 120: 7.8;
and S5, sequentially adding the intermediate 4 and sodium tert-butoxide into ethanol, slowly adding p-fluorobenzaldehyde dropwise after magnetically stirring for 10min, stirring at a constant speed and reacting for 4h, performing suction filtration after the reaction is finished, and purifying by column chromatography (V acetic acid: V petroleum ether = 1: 1) to prepare the insecticidal factor, wherein the weight ratio of the intermediate 4 to the sodium tert-butoxide to the p-fluorobenzaldehyde to the ethanol is controlled to be 2: 1.5: 1.8: 100.
Example 4
The insecticidal composition (wettable powder) containing imidacloprid and cyfluthrin and suitable for unmanned flying prevention comprises the following raw materials in parts by weight: 3 parts of insecticidal factor, 1 part of imidacloprid, 1 part of cyfluthrin, 5 parts of sodium lignosulfonate, 1 part of Arabic gum and 30 parts of diatomite;
the insecticidal composition (wettable powder) is prepared by the following steps:
weighing the raw materials according to the formula ratio, mixing, crushing and grinding to obtain the insecticidal composition containing the chlorantraniliprole and the clothianidin for unmanned aerial defense.
Example 5
The insecticidal composition (wettable powder) containing imidacloprid and cyfluthrin and suitable for unmanned flying prevention comprises the following raw materials in parts by weight: 8 parts of insecticidal factor, 5 parts of imidacloprid, 3 parts of cyfluthrin, 8 parts of sodium lignosulfonate, 2 parts of Arabic gum and 40 parts of diatomite;
the insecticidal composition (wettable powder) is prepared by the following steps:
weighing the raw materials according to the formula ratio, mixing, crushing and grinding to obtain the insecticidal composition containing the chlorantraniliprole and the clothianidin for unmanned aerial defense.
Example 6
The insecticidal composition (wettable powder) containing imidacloprid and cyfluthrin and suitable for unmanned flying prevention comprises the following raw materials in parts by weight: 10 parts of insecticidal factor, 10 parts of imidacloprid, 5 parts of cyfluthrin, 10 parts of sodium lignosulfonate, 3 parts of Arabic gum and 50 parts of diatomite;
the insecticidal composition (wettable powder) is prepared by the following steps:
weighing the raw materials according to the formula ratio, mixing, crushing and grinding to obtain the insecticidal composition containing the chlorantraniliprole and the clothianidin for unmanned aerial defense.
Comparative example 1
This comparative example compares to example 4, without the addition of an insecticidal factor.
Comparative example 2
This comparative example is an imidacloprid-containing insecticidal composition prepared by a commercially available company.
The treatment agents of example 4 to example 6 and comparative example 1 to comparative example 2 were mixed with water by a mist sprayer every 7 th late month for spraying, 18 kg of the liquid medicine per mu was sprayed, and the mortality of insect pests 14 days after spraying was calculated as relative control effects, and the results are shown in the following table:
example 4 Example 5 Example 6 Comparative example 1 Comparative example 2
The control effect is% 96.73 96.75 96.72 76.65 71.53
From the above table, it can be seen that the control effects of examples 4 to 6 are 96.72 to 96.75%, and the control effects of comparative examples 1 to 2 are 71.53 to 76.65%; therefore, when the insecticidal factor acts on insects, the insecticidal factor can directly act on acetylcholine receptors of the insects, and then generates toxic action on organisms of the insects, and generates stomach toxicity on the insects, so that lepidoptera, diptera and other pests are effectively killed, drug mutual resistance is not generated between the insecticidal factor and imidacloprid and cyfluthrin, the insecticidal factor can be cooperatively used, the insecticidal effect is enhanced, in addition, fluorine atoms are introduced into the structure of the insecticidal factor, and have good biological affinity, and the insecticidal effect on the insect organisms is further enhanced.
In the description of the specification, reference to the description of "one embodiment," "an example," "a specific example" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to limit the invention to the precise embodiments described, and various modifications, additions, and substitutions may be made by those skilled in the art without departing from the scope of the invention or exceeding the scope of the claims.

Claims (8)

1. The insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned flying prevention is characterized in that: the feed comprises the following raw materials in parts by weight: 3-10 parts of insecticidal factor, 1-10 parts of imidacloprid and 1-5 parts of cyfluthrin;
the insecticidal factor is prepared by the following steps:
step S1, adding calcium cyanamide into deionized water, stirring at a constant speed for 10min, adding 20% potassium hydroxide aqueous solution and polyethylene glycol 400, maintaining the reaction temperature at 0-10 ℃, stirring at a constant speed, slowly dropwise adding carbon disulfide, heating to 45 ℃ after dropwise adding, continuously stirring for 6h, filtering while hot to obtain a product, performing rotary evaporation until water is removed, washing with absolute ethyl alcohol for three times, and drying to obtain an intermediate 1;
step S2, adding the intermediate 1 into a mixed solvent, stirring at a constant speed for 30min, sequentially adding zirconium oxide, polyethylene glycol 400 and dimethyl carbonate, heating to 180 ℃, carrying out reflux reaction for 10h, and extracting and purifying after the reaction is finished to obtain an intermediate 2;
step S3, adding the intermediate 2 into ethanol, stirring at room temperature for 10min at a constant speed, slowly dropwise adding the solution a, heating to 40 ℃ after dropwise adding, stirring at a constant speed, reacting for 4h, distilling under reduced pressure to remove ethanol, and performing suction filtration to obtain an intermediate 3;
step S4, adding the intermediate 3 and sodium carbonate into acetonitrile, stirring at a constant speed for 15min, slowly dropwise adding chloroacetonitrile, stirring at a constant speed for 15min, heating, refluxing for 4h, cooling to room temperature after the reaction is finished, removing the solvent by rotary evaporation, and purifying to obtain an intermediate 4;
and S5, sequentially adding the intermediate 4 and sodium tert-butoxide into ethanol, slowly dropwise adding p-fluorobenzaldehyde after magnetically stirring for 10min, stirring at a constant speed, reacting for 4h, filtering after the reaction is finished, and purifying to obtain the insecticidal factor.
2. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: the formulation of the composition is any one of aqueous solution, granules, suspending agent, wettable powder and microemulsion.
3. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: the mixed solvent in the step S2 is formed by mixing deionized water, ethylene glycol, dodecyl phenol polyoxyethylene ether and Turkey red oil according to the weight ratio of 10: 1: 0.5.
4. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: in the step S3, the solution a is formed by mixing 2-aminoethanethiol hydrochloride and a sodium hydroxide aqueous solution with the mass fraction of 15% according to the weight ratio of 1: 2.
5. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: in the step S1, the weight ratio of the calcium cyanamide to the potassium hydroxide aqueous solution to the polyethylene glycol 400 to the carbon disulfide to the deionized water is controlled to be 20: 52.0-52.2: 1.5-1.6: 10.5-12.0: 100.
6. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: in the step S2, the weight ratio of the intermediate 1, the zirconia, the polyethylene glycol 400, the dimethyl carbonate and the mixed solvent is controlled to be 10: 0.5-0.6: 0.5: 45-50: 50.
7. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: the weight ratio of the intermediate 2 to the solution a in the step S3 is 43.5-45: 100-105.
8. The insecticidal composition containing imidacloprid and cyfluthrin suitable for unmanned flight control according to claim 1, wherein: in the step S4, the weight ratio of the intermediate 3, the sodium carbonate, the acetonitrile and the chloroacetonitrile is controlled to be 12.5: 12.5-13: 120: 7.5-7.8, and in the step S5, the weight ratio of the intermediate 4, the sodium tert-butoxide, the p-fluorobenzaldehyde and the ethanol is controlled to be 2: 1.3-1.5: 1.6-1.8: 100.
CN202211302296.3A 2022-10-24 2022-10-24 Insecticidal composition containing imidacloprid and cyfluthrin and suitable for unmanned aerial defense Pending CN115918671A (en)

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