CN115887532A - Pharmaceutical composition, preparation method and application thereof - Google Patents
Pharmaceutical composition, preparation method and application thereof Download PDFInfo
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- CN115887532A CN115887532A CN202211508631.5A CN202211508631A CN115887532A CN 115887532 A CN115887532 A CN 115887532A CN 202211508631 A CN202211508631 A CN 202211508631A CN 115887532 A CN115887532 A CN 115887532A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention relates to a pharmaceutical composition, a preparation method and application thereof, wherein the pharmaceutical composition comprises the following components in parts by weight: 5 to 30 portions of Yuanshu, 5 to 20 portions of borneol, 5 to 30 portions of realgar, 10 to 20 portions of angelica, 10 to 30 portions of asarum, 10 to 30 portions of rhubarb, 10 to 30 portions of rhizoma ligustici wallichii, 20 to 30 portions of angelica dahurica and 20 to 40 portions of mint. The preparation method comprises the following steps: cleaning the rhizoma atractylodis, asarum, angelica, rheum officinale, angelica dahurica, ligusticum wallichii and mint, drying in the sun, frying with slow fire for 20-30 minutes, spreading and radiating to normal temperature to obtain a dry standby product; and grinding borneol, realgar and the dried standby product into powder by using a medicine grinding machine or a grinding machine, controlling the particle size of the powder to be 200-300 meshes, and uniformly mixing according to the parts by weight. The pharmaceutical composition can enable the gingiva to subside swelling, and can be applied to the preparation of medicines for fundamentally treating toothache.
Description
Technical Field
The embodiment of the invention relates to a composition, a preparation method and application thereof, in particular to a pharmaceutical composition, a preparation method and application thereof.
Background
Teeth in the oral cavity are important gateways for human life, and if the teeth are damaged, the chewing capacity is reduced, the food quality entering the stomach of a human body is affected, and stomach diseases are easily formed in the past. In general, due to the influence of various factors, the hard tooth tissue undergoes inorganic demineralization and organic matter decomposition, which are carried out in a chronic progression, causing damage and defects to the tooth tissue, causing pain, and in the case of severe cases, causing tooth loss, pulpitis, periapical periodontitis, and the like, which become lesions.
In the prior art, a plurality of medicines for treating toothache mostly only relieve pain and cannot treat the toothache fundamentally, in addition, the toothache can cause a plurality of symptoms such as tooth root swelling and pain, tooth abscess and the like due to various reasons, and the existing medicines only relieve pain locally aiming at the toothache and cannot treat the toothache fundamentally.
Therefore, research and development of a medicament capable of fundamentally treating toothache are of great significance and pursued by many scientific researchers in the field.
Disclosure of Invention
After intensive research, the inventor provides a pharmaceutical composition, a preparation method and application thereof, and the pharmaceutical composition can fundamentally treat toothache.
In view of this, the present invention provides the following technical solutions:
a pharmaceutical composition comprises the following components in parts by weight:
5 to 30 portions of Yuanshu, 5 to 20 portions of borneol, 5 to 30 portions of realgar, 10 to 20 portions of angelica, 10 to 30 portions of asarum, 10 to 30 portions of rhubarb, 10 to 30 portions of rhizoma ligustici wallichii, 20 to 30 portions of angelica dahurica and 20 to 40 portions of mint.
Preferably, the range of 5 to 30 parts by weight includes any specific value ascribed thereto, such as 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and also includes ranges of any two of these specific values, such as 5 to 25, 5 to 20, 5 to 15, 5 to 10, 10 to 30, 10 to 25, 10 to 20, 10 to 15, 15 to 30, 15 to 25, 15 to 20, 20 to 30, 20 to 25, 25 to 30.
Preferably, the range of 5 to 20 parts by weight of borneol includes any specific value, such as 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, and also includes any two of these specific values, such as 5 to 15, 5 to 10, 10 to 20, 10 to 15, 15 to 20.
Preferably, the range of 5 to 30 parts by weight of the realgar includes any specific point value, such as 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 and 30, and also includes the range formed by any two point values of the specific point values, such as 5 to 25, 5 to 20, 5 to 15, 5 to 10, 10 to 30, 10 to 25, 10 to 20, 10 to 15, 15 to 30, 15 to 25, 15 to 20, 20 to 25 and 25 to 30.
Preferably, the asarum herb 10-30 weight parts range includes any specific value, such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and also includes any two of these specific values, such as 10-25, 10-20, 10-15, 15-30, 15-25, 15-20, 20-30, 20-25, 25-30.
Preferably, the range of 10 to 20 parts by weight of angelica includes any specific value, such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, and also includes any two of these specific values, such as 10 to 15, 15 to 20.
Preferably, the range of 10 to 30 parts by weight of rhubarb includes any specific value, such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and also includes any two of these specific values, such as 10 to 25, 10 to 20, 10 to 15, 15 to 30, 15 to 25, 15 to 20, 20 to 30, 20 to 25, 25 to 30.
Preferably, the range of 20 to 30 parts by weight of dahurian angelica root includes any specific values, such as 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and also includes any two values, such as 20 to 25, 25 to 30, of these specific values.
Preferably, the range of 10 to 30 parts by weight of chuanxiong rhizome includes any specific values, such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and also includes any two values of these specific values, such as 10 to 30, 10 to 25, 10 to 20, 10 to 15, 15 to 30, 15 to 25, 15 to 20, 20 to 30, 20 to 25, 25 to 30.
Preferably, the mint 20-40 weight parts range includes any specific value subsumed therein, such as 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 33, 34, 35, 36, 37, 38, 39, 40, and also includes any two of these specific values, such as 20-35, 20-30, 20-25, 25-40, 25-35, 25-30, 30-40, 30-35, 35-40.
The preparation method of the pharmaceutical composition comprises the following steps:
firstly, cleaning Yuanshu, asarum, angelica, rheum officinale, angelica dahurica, ligusticum wallichii and mint, drying in the sun, frying with slow fire by adopting a frying process in processing, controlling the frying time to be 20-30 minutes, preventing the stir-frying process from being overheated or pasty, spreading and radiating to a normal temperature state, and preventing the stir-frying process from being wetted to obtain a dry product to be used;
and step two, grinding the borneol, the realgar and the dried standby product into powder by using a medicine grinding machine or a grinding machine, controlling the particle size of the powder to be 200-300 meshes, and then uniformly mixing according to the parts by weight.
The application of the pharmaceutical composition in preparing the medicine for treating toothache, in particular to the application of the pharmaceutical composition in preparing the medicine for treating gingival swelling.
Compared with the prior art, the invention has the following beneficial effects:
when toothache occurs, the powder is taken and sucked in a proper amount, and pain can be relieved in a short time. The medicine is taken after 2 hours, and is taken with a proper amount of the medicine for suction, the medicine is taken not more than 3 times a day until the toothache disappears, and the medicine is stopped after the gum subsides, so that the toothache can be fundamentally treated.
The Chinese herbal medicine formula of the invention is mainly used for treating toothache by acting on the foot yangming stomach channel and the bearing meridian point of yangming two channels, such as toothache caused by tooth root swelling and pain, toothache caused by kidney deficiency and toothache caused by stomach fire and wind cold, and has obvious effects on the following diseases, namely tooth swelling and pain 1; 2. gingival inflammation and pain; 3. neuropathic toothache caused by periodontitis or pulpitis.
In the invention, yuan Shu acts on spleen and stomach; rhubarb, radix et rhizoma Rhei, purgative, purging pathogenic accumulation, clearing heat and purging fire, cooling blood and removing toxicity; realgar, for arresting epilepsy and inhibiting bacteria; borneol, which is used for inducing resuscitation and refreshing mind, can regulate excitation and inhibition of central nerves; herba asari has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, warming lung, and eliminating phlegm; angelica sinensis, having the effects of enriching and activating blood; the angelica dahurica dispels wind and removes dampness, promotes resuscitation and relieves pain, and has antibacterial effect; the ligusticum wallichii is used for dispelling wind and relieving pain and improving microcirculation; herba Menthae has effects of dispelling pathogenic wind and heat, refreshing mind, promoting eruption and relieving itching.
Detailed Description
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
The preparation method of the pharmaceutical composition provided by the invention comprises the following steps:
firstly, after Yuan Shu, asarum, angelica, rhubarb, angelica dahurica, ligusticum wallichii and mint are washed clean, aired and dried, the stir-frying process in the traditional Chinese medicine processing is adopted, stir-frying is carried out with slow fire, the stir-frying time is controlled to be 25 minutes, excessive fire or paste cannot exist, the materials are spread out and radiated to a normal temperature state and cannot be wetted, and a dry standby product is obtained;
step two, grinding borneol, realgar and the dried standby product into powder by using a medicine roller or a grinding machine, controlling the particle size of the powder to be 250 meshes, and then uniformly mixing the components in parts by weight according to the components in the table 1 to obtain the pharmaceutical compositions of the embodiments 1-7 of the invention and the corresponding proportion of the pharmaceutical compositions to be 1-3.
The clinical test method comprises the following steps: 8 adult patients suffering from toothache are adopted in each example, 5 adult patients suffering from toothache are adopted in each comparative example, the sex of each group of cases is unlimited, and the patients take the medicinal powder of the comparative example or the example once every 2 hours, the dosage is 20 mg each time, the time of one day is not more than 3 times, and the time lasts for 2 to 3 days.
TABLE 1 formulation compositions and test results of comparative examples and examples (the following components are used in parts by weight)
In conclusion, in the comparative example, when some components were absent, disappearance of toothache and gingival swelling could not be achieved. The pharmaceutical composition provided by each embodiment of the invention can relieve gingival swelling (gingival swelling disappears), and toothache disappears, so that toothache can be fundamentally treated.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications can be made without departing from the principle of the present invention, and these modifications should also be regarded as the protection scope of the present invention.
Claims (10)
1. The pharmaceutical composition is characterized by comprising the following components in parts by weight: 5 to 30 portions of Yuan shu, 5 to 20 portions of borneol, 5 to 30 portions of realgar, 10 to 20 portions of angelica, 10 to 30 portions of asarum, 10 to 30 portions of rhubarb, 10 to 30 portions of rhizoma ligustici wallichii, 20 to 30 portions of angelica dahurica and 20 to 40 portions of mint.
2. The pharmaceutical composition of claim 1, comprising the following components in parts by weight: 5 to 25 portions of Yuanshu, 5 to 20 portions of borneol, 5 to 25 portions of realgar, 10 to 20 portions of angelica, 10 to 25 portions of asarum, 10 to 25 portions of rhubarb, 10 to 25 portions of rhizoma ligustici wallichii, 20 to 30 portions of angelica dahurica and 20 to 35 portions of mint.
3. The pharmaceutical composition according to claim 2, comprising the following components in parts by weight: 5 to 20 portions of Yuanshu, 5 to 20 portions of borneol, 5 to 20 portions of realgar, 10 to 20 portions of angelica, 10 to 20 portions of asarum, 10 to 20 portions of rhubarb, 10 to 20 portions of rhizoma ligustici wallichii, 20 to 30 portions of angelica dahurica and 20 to 30 portions of mint.
4. The pharmaceutical composition of claim 3, comprising the following components in parts by weight: 5 to 15 portions of Yuanshu, 5 to 15 portions of borneol, 5 to 15 portions of realgar, 10 to 15 portions of angelica, 10 to 15 portions of asarum, 10 to 15 portions of rhubarb, 10 to 15 portions of rhizoma ligustici wallichii, 20 to 25 portions of angelica dahurica and 20 to 25 portions of mint.
5. The pharmaceutical composition of claim 4, comprising the following components in parts by weight: rhizoma atractylodis macrocephalae 5, borneol 5, realgar 5, asarum 10, angelica 10, rhubarb 10, angelica dahurica 20, ligusticum wallichii 10 and mint 20.
6. A process for preparing a pharmaceutical composition according to any one of claims 1 to 5, comprising the steps of:
firstly, cleaning Yuanshu, asarum, angelica, rheum officinale, angelica dahurica, ligusticum wallichii and mint, drying in the sun, frying with slow fire by adopting a frying process in processing, controlling the frying time to be 20-30 minutes, preventing the stir-frying process from being overheated or pasty, spreading and radiating to a normal temperature state, and preventing the stir-frying process from being wetted to obtain a dry product to be used;
and step two, grinding the borneol, the realgar and the dried standby product into powder by using a medicine grinding machine or a grinding machine, controlling the particle size of the powder to be 200-300 meshes, and then uniformly mixing according to the parts by weight.
7. The method of claim 6, wherein in step one, the stir-frying time is controlled to 25 minutes.
8. The method of claim 6, wherein in step two, the particle size of the powder is controlled to 250 mesh.
9. Use of a pharmaceutical composition according to any one of claims 1 to 5 for the manufacture of a medicament for the treatment of dental pain.
10. Use according to claim 9, wherein the pharmaceutical composition is for the manufacture of a medicament for the treatment of gingival swelling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211508631.5A CN115887532A (en) | 2022-11-29 | 2022-11-29 | Pharmaceutical composition, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211508631.5A CN115887532A (en) | 2022-11-29 | 2022-11-29 | Pharmaceutical composition, preparation method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN115887532A true CN115887532A (en) | 2023-04-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211508631.5A Pending CN115887532A (en) | 2022-11-29 | 2022-11-29 | Pharmaceutical composition, preparation method and application thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927362A (en) * | 2006-09-05 | 2007-03-14 | 魏信明 | Traditional Chinese powder medicine for treating toothache |
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- 2022-11-29 CN CN202211508631.5A patent/CN115887532A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927362A (en) * | 2006-09-05 | 2007-03-14 | 魏信明 | Traditional Chinese powder medicine for treating toothache |
Non-Patent Citations (1)
| Title |
|---|
| 柳专红;苏春芳;: "安痛滴丸压贴治疗龋齿性牙痛138例", 江西中医药, vol. 44, no. 07, pages 63 - 64 * |
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