CN115844986A

CN115844986A - Acanthopanax senticosus composition for relieving sore throat and tonifying qi as well as preparation method and application thereof

Info

Publication number: CN115844986A
Application number: CN202211696411.XA
Authority: CN
Inventors: 王小宇; 张洁
Original assignee: Heilongjiang Wusuli River Pharmaceutical Co ltd
Current assignee: Heilongjiang Wusuli River Pharmaceutical Co ltd
Priority date: 2022-12-28
Filing date: 2022-12-28
Publication date: 2023-03-28
Anticipated expiration: 2042-12-28
Also published as: CN115844986B

Abstract

The invention provides an acanthopanax senticosus composition for relieving sore throat and tonifying qi, and a preparation method and application thereof, wherein the acanthopanax senticosus composition comprises a combination of an extract A and an extract B; the extract A comprises the combination of acanthopanax extract and bitter almond extract; the extract B comprises the combination of a boat-fruited sterculia seed extract and a bulbus fritillariae cirrhosae extract. The extracts A and B have synergistic effect to improve the effects of strengthening spleen and supplementing qi, promoting the secretion of saliva or body fluid and benefiting lung, reducing phlegm and relieving cough of the composition, and the invention is a pure natural traditional Chinese medicine component, has no any additive component and no toxic or side effect, can be taken by oral liquid, tablets, capsules or granules and other dosage forms, does not need to be subjected to fussy decoction, can be drunk at any time, obviously improves the compliance of patients, has better treatment effect and has wide application prospect.

Description

Acanthopanax senticosus composition for relieving sore throat and tonifying qi as well as preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a acanthopanax composition for relieving sore throat and tonifying qi, and a preparation method and application thereof.

Background

Chronic pharyngitis (also called chronic pharyngitis) is a common disease, is a diffuse pharyngeal lesion caused by chronic infection, and has many causes, such as: acute pharyngitis attacks repeatedly and gradually changes into chronic pharyngitis; the mucous membrane of the posterior pharyngeal wall is often stimulated by the post-stream of inflammatory secretion of rhinitis and sinusitis; chronic tonsillitis and oral diseases irritate the pharyngeal mucosa; the nasal obstruction caused by diseases such as adenoid hypertrophy, nasal polyp, nasal septum deflection and the like loses the protective effect of the nasal cavity on the respiratory tract by oral respiration for a long time, so that dry, dusty, bacteria-rich and cold air directly stimulates pharyngeal mucosa; strong stimulation of smoke dust and chemical gas, excessive smoking and drinking, excessive speaking and other factors. According to statistics, the incidence rate of chronic pharyngitis accounts for 10% -12% of throat diseases, the chronic pharyngitis mostly occurs in adults, the urban incidence rate is high, professional practitioners such as teachers and singers are mostly used, and due to repeated attack, many discomforts are brought to patients.

The traditional Chinese medicine considers that the pathogenesis of the chronic pharyngitis is usually caused by viscera deficiency, yin deficiency and flaring up of deficient fire on the throat, or repeated attack of wind-heat and throat impediment, retention of residual evil, dust, stimulation of turbid qi, addiction to tobacco, wine, acrid taste, overexertion and the like, lung yin deficiency causes insufficient body fluid, the throat is not nourished by moistening, and the deficient fire is flaming along the channel; kidney yin deficiency, the meridians of the kidney are connected to the lung, and yin deficiency of the lung also causes up-flaming of deficient fire, which leads to obstruction of the throat. In addition, the deficient fire steaming up and causing the body fluid to turn into phlegm, and the obstruction of the channels and collaterals and the obstruction of qi movement cause qi stagnation and phlegm coagulation and phlegm-fire stagnation.

At present, no good medicine and a treatment method for treating the disease are clinically available, many patients go to each hospital repeatedly, and medicines applied in the market mostly have the defects of high medicine price, unsatisfactory treatment effect and the like, and most patients suffer from a lot of pains caused by side effects after taking a large amount of western medicines. Therefore, the existing generally applicable chronic pharyngitis treatment is mainly carried out by Chinese patent medicines, buccal tablets, aerosol inhalation and the like, but the pharyngitis is not healed for a long time due to the fact that many patients cannot insist on the treatment due to factors such as work reasons, living habits and the like, and a lot of troubles are brought to the life and work of the patients.

CN105582292A discloses a traditional Chinese medicine sore throat relieving tea for treating chronic pharyngolaryngitis and a preparation method thereof, the sore throat relieving tea is prepared from the following raw material medicines by weight: 12 parts of honeysuckle, 6 parts of dwarf lilyturf tuber, 6 parts of dark plum fruit, 6 parts of liquorice, 9 parts of radix rehmanniae, 9 parts of adenophora stricta, 6 parts of platycodon grandiflorum, 6 parts of fritillaria and 3 parts of oroxylum indicum. Weighing 12 parts of honeysuckle, 6 parts of dwarf lilyturf tuber, 6 parts of dark plum fruit, 6 parts of liquoric root, 9 parts of rehmannia root, 9 parts of adenophora stricta, 6 parts of platycodon grandiflorum, 6 parts of fritillaria and 3 parts of oroxylum indicum; drying the selected traditional Chinese medicine materials until the water content is less than or equal to 2%; putting the traditional Chinese medicine material with the water content less than or equal to 2% into a traditional Chinese medicine grinding machine for grinding, and grinding the traditional Chinese medicine material into powder with the granularity of 100 meshes; packaging the obtained medicinal powder into 12g teabags.

CN110051778B discloses a sore-throat relieving tea for treating chronic pharyngitis, which is prepared from the following raw materials in parts by weight: radix scrophulariae, radix ophiopogonis, radix rehmanniae, platycodon grandiflorum, scutellaria baicalensis, folium mori, radix pseudostellariae and honeysuckle according to a proportion of 1:1:1:1:1:1:1:1 proportion. Clinical and animal experiments prove that the sore-throat relieving tea combines various traditional Chinese medicines together to play a synergistic effect, has excellent anti-inflammatory and analgesic effects, and has remarkable improvement and treatment effects on chronic pharyngitis.

CN103816430B discloses a traditional Chinese medicine composition for treating asthma, which comprises the following components by weight: 2-10 parts of cimicifugae foetidae, 1-3 parts of indigo naturalis, 10-20 parts of houttuynia cordata, 5-10 parts of blackberry lily, 5-15 parts of platycodon grandiflorum, 5-15 parts of sterculia lychnophora, 5-15 parts of semen plantaginis, 5-15 parts of pericarpium citri reticulatae, 5-15 parts of exocarpium citri grandis, 5-15 parts of fried bighead atractylodes rhizome, 5-15 parts of acanthopanax, 10-20 parts of fried coix seed and 5-10 parts of liquorice.

The prior art discloses a plurality of composition health care products capable of treating chronic pharyngolaryngitis, however, the etiology of the chronic pharyngolaryngitis is often caused by viscera deficiency, yin deficiency and up-flaming of deficient fire in the throat, and the chronic pharyngolaryngitis treatment needs the functions of relieving sore throat and cough, tonifying qi and lung, strengthening spleen and kidney and the like, so that the development of a preparation capable of tonifying spleen and qi, promoting fluid production and benefiting lung, and reducing phlegm and stopping cough is the research focus in the field.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide an acanthopanax composition and a preparation method and application thereof, and particularly provides the acanthopanax composition for relieving sore throat and tonifying qi and the preparation method and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides an acanthopanax senticosus composition for relieving sore throat and tonifying qi, which comprises a combination of an extract A and an extract B.

The extract A comprises the combination of acanthopanax extract and bitter apricot seed extract.

The extract B comprises the combination of a boat-fruited sterculia seed extract and a bulbus fritillariae cirrhosae extract.

In the acanthopanax composition with the effects of relieving sore throat and tonifying qi, acanthopanax senticosus has the effects of tonifying qi and spleen, tonifying kidney and soothing nerves, and can be used for relieving symptoms such as spleen-lung qi deficiency, physical weakness and hypodynamia, inappetence, lung-kidney deficiency, chronic cough and asthma, heart-spleen deficiency and the like; the bitter apricot seeds have the effects of depressing qi, relieving cough and asthma and relaxing bowel, and can be used for relieving the symptoms of cough and asthma, fullness in chest and excessive phlegm, blood deficiency and fluid depletion, intestinal dryness and constipation and the like; semen Scaphii Lychnophori has effects of clearing heat, moistening lung, relieving sore throat, relieving constipation, and relieving hoarseness due to lung heat, dry cough without phlegm, dry throat, pain, heat accumulation, constipation, headache, conjunctival congestion, etc.; bulbus Fritillariae Cirrhosae has effects of clearing heat, moistening lung, eliminating phlegm, and relieving cough, and can be used for relieving and treating cough due to asthenia, expectoration, hemoptysis, heart and chest stagnation, pulmonary abscess, goiter, lymphoid tuberculosis, pharyngitis, and acute mastitis. The invention combines the acanthopanax extract and the bitter almond extract to obtain the extract A, thereby playing the main effects of relieving sore throat and tonifying qi; the extract B is obtained by combining the boat-fruited sterculia seed extract and the bulbus fritillariae cirrhosae extract, the extracts A and B can further enhance the effects of strengthening spleen and replenishing qi, promoting the production of body fluid and benefiting lung, reducing phlegm and stopping cough and the like of the composition under the synergistic action, and the acanthopanax senticosus composition is a pure natural traditional Chinese medicine component, has no additive component, no toxic or side effect, better treatment effect and wide application prospect.

Preferably, the acanthopanax composition comprises 3-5 parts of extract A, such as 3.5 parts, 4 parts, or 4.5 parts, etc., and 5-7 parts of extract B, such as 5.5 parts, 6 parts, or 6.5 parts, etc., in parts by weight.

Preferably, the extract a comprises 1 to 2 parts by weight of acanthopanax root extract, such as 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts, etc., and 2 to 3 parts by weight of bitter apricot seed extract, such as 2.2 parts, 2.4 parts, 2.6 parts or 2.8 parts, etc.

Preferably, the extract B comprises 2 to 3 parts by weight of the extract of scaphium scaphigerum, such as 2.2 parts, 2.4 parts, 2.6 parts or 2.8 parts, etc., and 3 to 4 parts by weight of the extract of fritillaria cirrhosa, such as 3.2 parts, 3.4 parts, 3.6 parts or 3.8 parts, etc.

Preferably, the acanthopanax senticosus extract is prepared by the following method, wherein the method comprises the following steps: extracting radix Acanthopanacis Senticosi, concentrating the extractive solution, and precipitating with ethanol to obtain radix Acanthopanacis Senticosi extract.

Preferably, the extracted extractant is water.

Preferably, the mass ratio of acanthopanax senticosus to water in the extraction is 1 (4-8), and can be, for example, 1.

Preferably, the extraction comprises reflux extraction or ultrasonic extraction, preferably ultrasonic extraction.

Preferably, the extraction time is 0.6-1.2h, for example, 0.7h, 0.8h, 0.9h, 1.0h or 1.1h, etc.

Preferably, the extraction is repeated 1-3 times, for example 1, 2 or 3 times, preferably 2 times.

Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

Preferably, the solvent used for alcohol precipitation is an aqueous ethanol solution.

Preferably, the volume fraction of ethanol in the ethanol aqueous solution is 85-95%, for example, 86%, 88%, 90%, 92%, 94%, etc.

Preferably, the material-liquid ratio of the alcohol precipitation is 1 (3-5), and for example, the material-liquid ratio can be 1.

Preferably, the alcohol precipitation time is 10-14h, for example, 11h, 12h or 13h and the like.

Preferably, the alcohol precipitation is repeated 1-3 times, for example 1, 2 or 3 times, preferably 2 times.

Preferably, the ethanol precipitation also comprises drying.

Preferably, the drying temperature is 50-70 ℃, for example, 55 ℃, 60 ℃ or 65 ℃, and the drying time is 0.5-1.5h, for example, 0.6h, 0.8h, 1.0h, 1.2h or 1.4 h.

Preferably, the drying further comprises crushing and sieving.

Preferably, the mesh number of the screen for sieving is 110-130 meshes, and for example, the mesh number can be 115 meshes, 120 meshes, 125 meshes and the like.

Preferably, the bitter almond extract is prepared by a method comprising: extracting semen Armeniacae amarum, and concentrating the obtained extractive solution to obtain semen Armeniacae amarum extract.

Preferably, the extracted extractant is water.

Preferably, the mass ratio of the bitter almond to the extractant is 1 (4-8), and can be, for example, 1.

Preferably, the extraction time is 0.8-1.5h, for example, 0.9h, 1.0h, 1.2h or 1.4h, etc.

Preferably, the concentration of the extract solution further comprises drying, crushing and sieving.

Preferably, the drying temperature is 50-70 ℃, for example, 55 ℃, 60 ℃ or 65 ℃, and the drying time is 0.8-1.5h, for example, 0.9h, 1.0h, 1.2h or 1.4 h.

Other specific values within the above ranges can be selected, and are not described in detail herein.

Preferably, the extract B also comprises a platycodon root extract and/or a jujube extract.

Preferably, the extract B comprises, by weight, 2 to 3 parts of a scaphium scaphigerum extract, such as 2.2 parts, 2.4 parts, 2.6 parts or 2.8 parts, etc., 3 to 4 parts of a fritillaria cirrhosa extract, such as 3.2 parts, 3.4 parts, 3.6 parts or 3.8 parts, etc., 2 to 3 parts of a platycodon grandiflorum extract, such as 2.2 parts, 2.4 parts, 2.6 parts or 2.8 parts, etc., 3 to 6 parts of a jujube extract, such as 3.5 parts, 4 parts, 4.5 parts, 5 parts or 5.5 parts, etc.

According to the invention, platycodon grandiflorum and jujube can be selectively added into the extract B, and the platycodon grandiflorum has the effects of dispersing lung qi, relieving sore throat, eliminating phlegm and expelling pus, and can be used for relieving symptoms such as cough with excessive phlegm, chest distress, sore throat, hoarseness, lung carbuncle and empyesis; the Chinese date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, and can be used for relieving the symptoms of spleen deficiency, poor appetite, weakness, loose stool and the like.

Preferably, the extract B is prepared by a method comprising: mixing semen Scaphii Lychnophori, bulbus Fritillariae Cirrhosae, optionally radix Platycodi, and optionally fructus Jujubae, and extracting to obtain extract B.

Preferably, the extracted extractant is water.

Preferably, the ratio of the extracted materials to the liquid is 1 (6-12), and for example, the ratio can be 1.

Preferably, the extraction further comprises concentrating the extract, drying, pulverizing, and sieving.

Preferably, the acanthopanax composition further comprises an extract C, wherein the extract C comprises any one or a combination of at least two of a liquorice extract, a codonopsis pilosula extract, an American ginseng extract and a Chinese yam extract.

Preferably, the extract C includes, by weight, 2 to 4 parts of licorice extract, for example, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, 3.2 parts, 3.4 parts, 3.6 parts, or 3.8 parts, etc., 2 to 3 parts of codonopsis pilosula extract, for example, 2.2 parts, 2.4 parts, 2.6 parts, or 2.8 parts, etc., 1 to 2 parts of american ginseng extract, for example, 1.2 parts, 1.4 parts, 1.6 parts, or 1.8 parts, etc., and 3 to 5 parts of yam extract, for example, 3.5 parts, 4 parts, or 4.5 parts, etc.

Preferably, the acanthopanax senticosus extract comprises 3-6 parts of extract C by weight, for example, 3.5 parts, 4 parts or 5 parts.

In the invention, the radix glycyrrhizae, the codonopsis pilosula, the American ginseng and the Chinese yam are added into the acanthopanax composition, and the radix glycyrrhizae has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the other drugs; the codonopsis pilosula has the effects of tonifying spleen and lung, nourishing blood and promoting the production of body fluid; american ginseng has the effects of tonifying qi, nourishing yin, clearing heat and promoting fluid production; the Chinese yam has the effects of tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney and arresting seminal emission, and the addition of the four raw materials further enhances the effects of relieving sore throat and tonifying qi of the composition.

Preferably, the extract C is prepared by a method comprising: mixing Glycyrrhrizae radix, radix Codonopsis, radix Panacis Quinquefolii, and rhizoma Dioscoreae, and extracting to obtain extract C.

Preferably, the extracted extractant is water.

Preferably, the ratio of the extracted materials to the liquid is 1 (4-10), and for example, the ratio can be 1.

In a second aspect, the present invention provides a method for preparing the acanthopanax root composition according to the first aspect, comprising: mixing extract A, extract B and optionally extract C uniformly to obtain the radix Acanthopanacis Senticosi composition.

In a third aspect, the present invention provides a use of the acanthopanax root composition according to the first aspect in health care products or medicines.

Preferably, the health product and the medicine respectively and independently comprise any one of oral liquid, tablets, capsules or granules.

Compared with the prior art, the invention has the following beneficial effects:

the acanthopanax senticosus composition with the effects of relieving sore throat and tonifying qi provided by the invention has the effects of tonifying qi and spleen, tonifying kidney and soothing nerves; the bitter apricot seeds have the effects of depressing qi, relieving cough and asthma and relaxing bowel; the boat-fruited sterculia seed has the effects of clearing heat, moistening lung, relieving sore throat, easing up voice and relaxing bowel; bulbus Fritillariae Cirrhosae has effects of clearing heat, moistening lung, eliminating phlegm, and relieving cough. The radix acanthopanacis senticosi, the bitter apricot kernel, the boat-fruited sterculia seed and the unibract fritillary bulb are combined together to improve the effects of strengthening spleen and supplementing qi, promoting the secretion of saliva or body fluid and benefiting lung, reducing phlegm and stopping cough and the like of the composition under the synergistic action, and through the design and further optimization of the components, the platycodon root and the Chinese date can be selectively added, the platycodon root has the effects of freeing lung, relieving sore throat, eliminating phlegm and expelling pus; the Chinese dates have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, and the Chinese dates can increase the flavor of the composition, improve the effects of relieving sore throat and tonifying Qi of the composition and simultaneously enhance the compliance of patients. The acanthopanax composition is a pure natural traditional Chinese medicine component, has no additive component and no toxic or side effect, can be taken by oral liquid, tablets, capsules or granules and other dosage forms, does not need to be decocted in a fussy way, can be drunk at any time, obviously improves the compliance of patients, has better treatment effect and has wide application prospect.

Detailed Description

The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.

The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

"optional" or "either" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

The indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the number clearly indicates the singular.

Reference throughout this specification to "one embodiment," "some embodiments," "exemplary," "specific examples" or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this document, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example.

Preparation example 1

The preparation example provides an extract A, which comprises the following components in parts by weight: 2 parts of acanthopanax root extract and 2 parts of bitter apricot seed extract.

The preparation method of the extract A comprises the following steps:

(1) Preparing an acanthopanax extract: cleaning radix Acanthopanacis Senticosi, oven drying in a 60 deg.C drying oven, crushing properly, weighing 2 parts, adding 6 times of water, ultrasonic extracting for 1h with power of 250W and frequency of 50kHz, filtering, collecting filtrate, adding 8 times of water, ultrasonic extracting for 50min under the same conditions, filtering, mixing filtrates obtained by two water extractions, concentrating the filtrate with a rotary evaporator to obtain extractive solution, adding 3 times of 90% ethanol water solution, stirring, precipitating with ethanol for 12h, removing supernatant, repeating the same conditions for one time, drying the obtained precipitate in a 60 deg.C drying oven for 1h, pulverizing, and sieving with 120 mesh sieve to obtain radix Acanthopanacis Senticosi extract.

(2) Preparing bitter almond extract: cleaning bitter almond, drying in a drying oven at 60 ℃, crushing properly, weighing 2 parts, adding 6 times of water, extracting with ultrasound (power 250W and frequency 50 kHz) for 1h, filtering, taking filtrate, adding 8 times of water, extracting with ultrasound for 50min under the same condition, filtering, combining filtrates obtained by two water extractions, concentrating the filtrate with a rotary evaporator to obtain extract, drying in the drying oven for 1.5h, crushing, and sieving with a 120-mesh sieve to obtain bitter almond extract.

(3) Mixing radix Acanthopanacis Senticosi extract and semen Armeniacae amarum extract uniformly to obtain extract A.

Preparation example 2

The preparation method of the extract A comprises the following steps:

the only difference from the preparation method in preparation example 1 is that the preparation method of acanthopanax senticosus extract, namely step (1), is different, and step (1) of the preparation example is as follows:

cleaning radix Acanthopanacis Senticosi, oven drying at 60 deg.C, crushing, weighing 2 parts, adding 6 times of water, ultrasonic extracting for 1 hr with power of 250W and frequency of 50kHz, filtering, collecting filtrate, adding 8 times of water, ultrasonic extracting for 50min under the same conditions, filtering, mixing filtrates obtained by two water extractions, concentrating the filtrate with rotary evaporator to obtain extractive solution, drying at 60 deg.C for 1 hr, pulverizing, and sieving with 120 mesh sieve to obtain radix Acanthopanacis Senticosi extract.

Preparation example 3

The preparation example provides an extract B, which comprises the following components in parts by weight: 2 parts of boat-fruited sterculia seed extract and 3 parts of bulbus fritillariae cirrhosae extract.

The preparation method of the extract B comprises the following steps:

cleaning semen Scaphii Lychnophori and Bulbus Fritillariae Cirrhosae, oven drying in a drying oven at 60 deg.C, crushing properly, weighing 2 parts of semen Scaphii Lychnophori and 3 parts of Bulbus Fritillariae Cirrhosae, mixing, adding 8 times of water, ultrasonic (power 250W, frequency 50 kHz) extracting for 1h, filtering, collecting filtrate, repeatedly extracting with water under the same conditions for one time, filtering, mixing filtrates obtained by two water extractions, concentrating the filtrate with rotary evaporator to obtain extractive solution, drying in the drying oven for 1.5h, pulverizing, and sieving with 120 mesh sieve to obtain extract B.

Preparation example 4

The preparation example provides an extract B, which comprises the following components in parts by weight: 2 parts of boat-fruited sterculia seed extract, 3 parts of bulbus fritillariae cirrhosae extract, 2 parts of platycodon root extract and 3 parts of jujube extract.

The preparation method of the extract B comprises the following steps:

cleaning semen Scaphii Lychnophori, bulbus Fritillariae Cirrhosae, radix Platycodi and fructus Jujubae, oven drying in a 60 deg.C drying oven, crushing properly, weighing semen Scaphii Lychnophori 2 parts, bulbus Fritillariae Cirrhosae 3 parts, radix Platycodi 2 parts and fructus Jujubae 3 parts, mixing, adding 8 times of water, ultrasonic extracting for 1 hr with ultrasonic wave (power 250W and frequency 50 kHz), filtering, collecting filtrate, repeatedly extracting with water under the same condition, filtering, mixing filtrates obtained by two water extractions, concentrating the filtrate with rotary evaporator to obtain extractive solution, drying in the drying oven for 1.5 hr, pulverizing, and sieving with 120 mesh sieve to obtain extract B.

Preparation example 5

The preparation example provides an extract C, which comprises the following components in parts by weight: 2 parts of licorice extract, 3 parts of codonopsis pilosula extract, 2 parts of American ginseng extract and 3 parts of Chinese yam extract.

The preparation method of the extract C comprises the following steps:

cleaning Glycyrrhrizae radix, radix Codonopsis, radix Panacis Quinquefolii, and rhizoma Dioscoreae, oven drying in a 60 deg.C drying oven, crushing moderately, weighing Glycyrrhrizae radix extract 2 parts, radix Codonopsis extract 3 parts, radix Panacis Quinquefolii extract 2 parts, and rhizoma Dioscoreae extract 3 parts, mixing, adding 7 times of water, ultrasonic (power 250W, frequency 50 kHz) extracting for 1.2h, filtering, collecting filtrate, repeatedly extracting with water under the same conditions, filtering, mixing filtrates obtained by two water extractions, concentrating the filtrate with rotary evaporator to obtain extractive solution, drying in the drying oven for 1.5h, pulverizing, and sieving with 120 mesh sieve to obtain extract C.

Comparative preparation example 1

This comparative preparation provides an extract a, which was prepared as follows:

the only difference from the preparation method in preparation example 1 is that only step (1) is performed to obtain the acanthopanax senticosus extract, i.e. extract a, and step (2) and step (3) are not performed.

Comparative preparation example 2

the difference from the preparation method in preparation example 1 is that only step (2) is performed to obtain the bitter apricot kernel extract, namely extract A, and step (1) and step (3) are not performed.

Example 1

The embodiment provides a radix acanthopanacis senticosi composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 5 parts of extract A, 6 parts of extract B and 5 parts of extract C.

The preparation method of the acanthopanax composition comprises the following steps: mixing 5 parts of extract A obtained in preparation example 1, 6 parts of extract B obtained in preparation example 4, and 5 parts of extract C obtained in preparation example 5, and subpackaging 16g per bag to obtain radix Acanthopanacis Senticosi composition.

Example 2

The embodiment provides a radix acanthopanacis senticosi composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 5 parts of extract A, 5 parts of extract B and 4 parts of extract C.

The preparation method of the acanthopanax composition comprises the following steps: 5 parts of extract A obtained in preparation example 1, 5 parts of extract B obtained in preparation example 4 and 4 parts of extract C obtained in preparation example 5 were mixed uniformly, and the mixture was packed in 16g portions per bag to obtain an Acanthopanax senticosus composition.

Example 3

The preparation method of the acanthopanax composition comprises the following steps: the only difference from the preparation method of example 1 is that the extract B obtained in preparation example 4 was replaced with the extract B obtained in preparation example 3 of equal quality, and the remaining components, amounts and preparation method were the same as in example 1.

Example 4

The embodiment provides a radix acanthopanacis senticosi composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 8 parts of extract A, 3 parts of extract B and 5 parts of extract C.

The preparation method of the acanthopanax senticosus composition is the same as that in the example 1.

Example 5

The embodiment provides a radix acanthopanacis senticosi composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 2 parts of extract A, 9 parts of extract B and 5 parts of extract C.

Example 6

The preparation method of the acanthopanax composition comprises the following steps: the only difference from the preparation method of example 1 is that the extract a obtained in preparation example 1 was replaced with the extract a obtained in preparation example 2 of equal quality, and the remaining components, amounts and preparation methods were the same as those of example 1.

Example 7

The embodiment provides a radix acanthopanacis senticosi composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 7.2 parts of extract A and 8.8 parts of extract B.

The preparation method of the acanthopanax composition comprises the following steps: 7.2 parts of the extract A obtained in preparation example 1 and 8.8 parts of the extract B obtained in preparation example 4 were mixed uniformly, and the mixture was packed in bags of 16g each to obtain an Acanthopanax senticosus composition.

Comparative example 1

The comparative example provides an acanthopanax composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 5 parts of extract A, 6 parts of extract B and 5 parts of extract C.

The preparation method of the acanthopanax composition comprises the following steps: the only difference from the preparation method of example 1 is that the extract a obtained in preparation example 1 is replaced by the extract a obtained in comparative preparation example 1 of equal quality, and the remaining components, amounts and preparation methods are the same as those of example 1.

Comparative example 2

The preparation method of the acanthopanax composition comprises the following steps: the only difference from the preparation method of example 1 is that the extract a obtained in preparation example 1 was replaced with the extract a obtained in comparative preparation example 2 of equal quality, and the remaining components, amounts and preparation methods were the same as those of example 1.

Comparative example 3

The comparative example provides an acanthopanax composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 8 parts of extract A and 8 parts of extract C.

The preparation method of the acanthopanax composition comprises the following steps: mixing 8 parts of extract A obtained in preparation example 1 and 8 parts of extract C obtained in preparation example 5, and packaging 16g per bag to obtain radix Acanthopanacis Senticosi composition.

Comparative example 4

The comparative example provides an acanthopanax composition for relieving sore throat and tonifying qi, which comprises the following components in parts by weight: 8.8 parts of extract B and 7.2 parts of extract C.

The preparation method of the acanthopanax composition comprises the following steps: 8.8 parts of the extract B obtained in preparation example 4 and 7.2 parts of the extract C obtained in preparation example 5 were mixed uniformly, and the mixture was packed in 16g portions per bag to obtain an Acanthopanax senticosus composition.

Test example 1

According to the throat clearing function inspection method specified in health food inspection and evaluation specifications, a rat toe swelling experiment is selected to research and discuss the throat clearing function of the throat clearing sugar, inflammation diminishing and throat clearing.

The test method comprises the following steps: rats were randomly divided into 5 groups of 10 rats each by body mass. The 3 dose groups were 2.0g/kg, 4.0g/kg, and 8.0 g/kg. The acanthopanax senticosus composition obtained in example 1 is pulverized, and low, medium and high 3 dosage groups are respectively added with water and steam according to 3 concentrations of 0.2g/ml, 0.4g/ml and 0.8g/ml, stirred and dissolved fully, and steam-released water is used as blank control to be administered by oral gavage, wherein the gavage volume is 10ml/kg body mass, and the administration is carried out continuously for 30 days. On the day of experiment termination, after the last 1-time administration of the test substance, the rats were inflamed by injecting 1% carrageenan (0.1 ml/mouse) subcutaneously into the right hind paw plantar region, and the thickness of the plantar region of each rat was measured at 1h, 3h and 6h after the inflammation, and 3 times of measurement of the same site, and the average value was taken. The differences in thickness of the plantar region of the foot at different time points were compared between the rats in each dose group and the rats in the control group.

And (3) testing results: compared with a blank control group, the difference of the thicknesses of the foot soles before and after stimulation at any time point is obviously reduced, the difference has statistical significance, and the animal test result of the test sample can be judged to be positive.

Statistical treatment: experimental data were analyzed for one-way anova with SPSS 11.5 software. Through the homogeneity of variance test, the experimental data with the uniform variance is statistically analyzed by adopting an LSD method, the experimental data with the non-uniform variance is statistically analyzed by adopting a Tambane method, and the difference P <0.05 is taken as the statistical significance.

The throat clearing function test researches the throat clearing effect of the acanthopanax composition obtained in example 1 by an animal anti-inflammation experiment, and in the test process, rats in a sample group and a control group have normal lives and have no bad characteristics.

Test example 2

According to the standard in the guideline for prevention and treatment of bronchial asthma (the guideline for prevention and treatment of bronchial asthma of the division of respiratory pathology of the Chinese medical society, china tuberculosis and journal of respiration, 1997, 20 (5): 261), the patient is diagnosed as bronchial asthma by X-ray radiography, blood routine examination and the like. The traditional Chinese medicine diagnosis conforms to the clinical research guide principle of new traditional Chinese medicines (the national Ministry of public health department of the people's republic of China, the clinical research guide principle of new traditional Chinese medicines CN103816430A, page 43/3, 5 beds), the 1 st edition Nanjing: nanjing university Press, 1994), and the syndrome belongs to phlegm-heat \39252lung. The clinical manifestations are as follows: cough and asthma, wheezy phlegm in the throat, yellow and sticky sputum, little and unsmooth sputum, vexation in the chest, inability to lie down at night, red tongue with yellow and greasy coating.

The patients meeting the above criteria are selected for 360 cases and divided into 12 groups (11 groups are treatment groups, 1 group is control group), wherein 185 cases of men and 175 cases of women are aged 15-67 years old, the average age is 43.5 years old, the average course is 25 days, and the course and the symptom of each group of cases are basically consistent, have no obvious difference and are comparable.

The acanthopanax senticosus composition for relieving sore throat and tonifying qi is taken by a treatment group, 3 times a day, 1 bag each time in the morning, noon and evening, and is continuously taken for 15 days, and the dosage of patients with serious disease conditions is increased according to the advice of doctors.

And (3) judging the curative effect:

and (3) curing: the pharyngalgia, cough and complication disappear completely, the body returns to normal;

the effect is shown: the symptoms of pharyngalgia, cough and complication are obviously relieved, and the body is obviously improved;

the method has the following advantages: the symptoms of pharyngalgia, cough and complication are relieved, and the body is improved;

and (4) invalidation: the symptoms were not reduced or exacerbated.

The results are shown in table 1:

TABLE 1

According to the data in the table 1, when the proportion of the extract A is too high or too low, the product of the application is not beneficial to exerting the effects of relieving sore throat and tonifying qi, and the absence of acanthopanax or bitter apricot seeds in the extract A is not beneficial to exerting the effects of relieving sore throat and tonifying qi, the acanthopanax and bitter apricot seeds have a synergistic effect, so that the treatment effect is better; in the preparation process of the acanthopanax senticosus extract, an alcohol precipitation process is used, so that the obtained product has more excellent curative effect; the platycodon root and the Chinese date are added into the extract B, so that the sore throat relieving and qi tonifying effects of the acanthopanax composition provided by the invention can be effectively improved; the extract A, the extract B and the extract C have synergistic effect, so that the acanthopanax composition provided by the invention has good effects of relieving sore throat and tonifying qi.

The applicant states that the present invention is illustrated by the above embodiments, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must be implemented depending on the above embodiments. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims

1. The acanthopanax senticosus composition for relieving sore throat and tonifying qi is characterized by comprising a combination of an extract A and an extract B;

the extract A comprises the combination of acanthopanax extract and bitter apricot seed extract;

2. The acanthopanax root composition according to claim 1, comprising 3-5 parts of extract A, 5-7 parts of extract B;

preferably, the extract A comprises 1-2 parts of acanthopanax root extract and 2-3 parts of bitter almond extract in parts by weight;

preferably, the extract B comprises 2-3 parts of boat-fruited sterculia seed extract and 3-4 parts of bulbus fritillariae cirrhosae extract by weight.

3. The acanthopanax senticosus composition according to claim 1 or 2, wherein the acanthopanax senticosus extract is prepared by the following method comprising: extracting radix Acanthopanacis Senticosi, concentrating the obtained extractive solution, and precipitating with ethanol to obtain radix Acanthopanacis Senticosi extract;

preferably, the extracted extractant is water;

preferably, the mass ratio of the acanthopanax senticosus to the water during extraction is 1 (4-8);

preferably, the extraction comprises reflux extraction or ultrasonic extraction, preferably ultrasonic extraction;

preferably, the extraction time is 0.6-1.2h;

preferably, the extraction is repeated 1-3 times.

4. The acanthopanax senticosus composition according to claim 3, wherein the solvent used for alcohol precipitation is an aqueous ethanol solution;

preferably, the volume fraction of ethanol in the ethanol aqueous solution is 85-95%;

preferably, the material-liquid ratio of the alcohol precipitation is 1 (3-5);

preferably, the alcohol precipitation time is 10-14h;

preferably, the alcohol precipitation is repeated for 1-3 times;

preferably, the alcohol precipitation also comprises drying;

preferably, the drying temperature is 50-70 ℃, and the drying time is 0.5-1.5h;

preferably, the drying further comprises crushing and sieving;

preferably, the mesh number of the screen is 110-130 meshes.

5. The Acanthopanax senticosus composition according to any one of claims 1 to 4, wherein the almond extract is prepared by a method comprising: extracting semen Armeniacae amarum, and concentrating the obtained extractive solution to obtain semen Armeniacae amarum extract;

preferably, the extracted extractant is water;

preferably, the mass ratio of the bitter almond to the extracting agent is 1 (4-8);

preferably, the extraction time is 0.8-1.5h;

preferably, the extraction is repeated 1-3 times;

preferably, the step of concentrating the extracting solution further comprises drying and sieving;

preferably, the drying temperature is 50-70 ℃, and the drying time is 0.8-1.5h;

preferably, the mesh number of the screen for sieving is 110-130 meshes.

6. The Acanthopanax senticosus composition according to any one of claims 1 to 5, wherein the extract B further comprises a Platycodon grandiflorum extract and/or a Zizyphi fructus extract;

preferably, the extract B comprises 2-3 parts by weight of boat-fruited sterculia seed extract, 3-4 parts by weight of bulbus fritillariae cirrhosae extract, 2-3 parts by weight of platycodon grandiflorum extract and 3-6 parts by weight of jujube extract.

7. The Acanthopanax senticosus composition according to any one of claims 1 to 6, wherein the extract B is prepared by a method comprising: mixing semen Scaphii Lychnophori, bulbus Fritillariae Cirrhosae, optionally radix Platycodi, and optionally fructus Jujubae, and extracting to obtain extract B;

preferably, the extractant of the extraction is water;

preferably, the ratio of the extracted materials to the extracted liquids is 1 (6-12);

preferably, the extraction is repeated 1-3 times;

preferably, the extraction also comprises concentrating the extract, drying and sieving;

preferably, the mesh number of the screen is 110-130 meshes.

8. The Acanthopanax senticosus composition according to any one of claims 1 to 7, further comprising an extract C comprising any one or a combination of at least two of an extract of licorice, an extract of Codonopsis pilosula, an extract of Panax quinquefolium, and an extract of Dioscorea opposita;

preferably, the extract C comprises 2-4 parts of licorice extract, 2-3 parts of codonopsis pilosula extract, 1-2 parts of American ginseng extract and 3-5 parts of Chinese yam extract in parts by weight;

preferably, the extract C is prepared by a method comprising: mixing Glycyrrhrizae radix, radix Codonopsis, radix Panacis Quinquefolii, and rhizoma Dioscoreae, and extracting to obtain extract C;

preferably, the extracted extractant is water;

preferably, the ratio of the extracted materials to the extracted liquids is 1 (4-10);

preferably, the extraction is repeated 1-3 times;

preferably, the mesh number of the screen for sieving is 110-130 meshes.

9. A method for preparing the acanthopanax senticosus composition according to any one of claims 1-8, comprising: mixing extract A, extract B and optionally extract C uniformly to obtain the radix Acanthopanacis Senticosi composition.

10. Use of the acanthopanax senticosus composition according to any one of claims 1-8 in health care products or medicines;