CN115844366A - Hand-held type breast tumour detection device based on magnetic particle formation of image - Google Patents
Hand-held type breast tumour detection device based on magnetic particle formation of image Download PDFInfo
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Abstract
The invention belongs to the technical field of magnetic particle imaging, and particularly relates to a handheld breast tumor detection device and method based on magnetic particle imaging, and electronic equipment, aiming at solving the problems of large equipment volume, high specialization degree and low sensitivity of the existing tumor detection method. The device comprises: the device comprises a coil module, a power supply module, a mechanical auxiliary module, a signal preprocessing module and a control, signal processing and visualization module; the coil module comprises a plurality of groups of coil probes arranged in parallel; the coil probe includes a driving coil unit, a receiving coil unit, and a compensation coil unit. The breast tumor detection device is smaller in size, convenient and fast to detect in a handheld mode, improves the breast tumor detection sensitivity, reduces the difficulty in interpreting the breast tumor, and is more beneficial to treatment of the breast tumor.
Description
Technical Field
The invention belongs to the technical field of magnetic particle imaging, and particularly relates to a handheld breast tumor detection device and method based on magnetic particle imaging, and electronic equipment.
Background
At present, the commonly used detection means of breast tumors mainly comprise CT imaging, X-ray tomography, nuclear magnetic resonance and the like, but the detection means have the defects of large equipment volume, high specialization degree, high detection cost and the like, so the equipment cannot be portable and can only be used in professional medical places. In addition, some portable detection devices designed according to the physicochemical properties of the cancer site, such as a detector based on bioelectrical impedance imaging and based on the content of nitrogen oxides in blood, have low detection sensitivity and high detection accuracy due to the fact that the physicochemical properties of the human body are interfered by various factors and fluctuation of the physicochemical properties of the human body. The detection effect of the equipment still needs to be verified experimentally and clinically, and the equipment is not used on a large scale. Therefore, there is a need in clinical practice for a portable device that can detect breast tumors with high sensitivity.
Magnetic particle imaging is a new medical imaging modality, and has the advantages of high sensitivity, no signal attenuation along with depth, safety and no tissue background signal interference. The handheld device based on the imaging modality can be used for high-sensitivity detection of breast tumors so as to realize early detection and early treatment of the breast tumors. Based on the above, the invention provides a handheld breast tumor detection device based on magnetic particle imaging.
Disclosure of Invention
In order to solve the above problems in the prior art, that is, to solve the problems of large volume, high specialization degree and low sensitivity of the existing breast tumor detection device, the present invention provides a handheld breast tumor detection device based on magnetic particle imaging, which comprises:
the coil module comprises a plurality of groups of coil probes arranged in parallel; the coil probe comprises a driving coil unit, a receiving coil unit and a compensating coil unit;
the driving coil unit comprises a driving coil wound on the outer surface of the first cylinder; the first cylinder is a hollow cylinder; the driving coil unit is configured to construct a driving field, so that the magnetic particles generate a nonlinear response;
the receiving coil unit comprises a receiving coil wound at one end of the outer surface of the second cylinder; the second cylinder is positioned inside the first cylinder, and the second cylinder is coaxial with the first cylinder; the receiving coil unit is configured to convert the change of the magnetic field caused by the nonlinear response into a voltage signal as a first voltage signal;
the compensation coil unit comprises a compensation coil wound at the other end of the outer surface of the second cylinder; the compensation coil unit is configured to acquire magnetic field information and compensate the receiving coil;
the mechanical auxiliary module comprises a coil fixing device, device fixing equipment and a hand-held mechanical arm;
the coil fixing device is arranged at one end close to the compensation coil; the coil fixing device is configured to fix each coil in the coil module and maintain the relative position of the coils;
the handheld mechanical arm is a multi-degree-of-freedom mechanical arm, one end of the handheld mechanical arm is connected with the device fixing equipment, and the other end of the handheld mechanical arm is connected with the coil fixing device; the handheld mechanical arm is configured to move and rotate the coil module and the coil fixing device;
the device fixing equipment is of a box structure and is connected with the tail end of the hand mechanical arm; the device fixing equipment is used for fixing the mechanical arm device;
the signal preprocessing module is configured to preprocess the first voltage signal to obtain a second voltage signal;
the control, signal processing and visualization module is configured to control current change of a driving coil in the coil module according to a set control instruction, so as to realize scanning imaging of a target to be detected.
In some preferred embodiments, the handheld breast tumor detection device based on magnetic particle imaging further comprises a power supply module; the mechanical auxiliary module also comprises a coil cooling device;
the power supply module comprises a voltage transformer, a frequency conversion circuit, a filter circuit and a voltage stabilizing circuit; the power supply module is configured to convert a first alternating current into a second alternating current according to a control signal and input the second alternating current into a driving coil in the coil module; the first alternating current is the alternating current input by the handheld breast tumor detection device based on magnetic particle imaging;
the coil cooling device is a thin tube wound outside the driving coil; and the coil cooling device is used for cooling heat generated when the driving coil works.
In some preferred embodiments, the device fixing apparatus is further configured to install a hardware device of the control module of the power supply module, the signal preprocessing module and the control, signal processing and visualization module, and a single chip device of the signal processing and visualization module.
In some preferred embodiments, the non-linear response is expressed by the langevin equation:
In some preferred embodiments, the first alternating current is converted to a second alternating current by;
receiving control signals of alternating current needed by each module in the handheld breast tumor detection device based on magnetic particle imaging; reading parameters of the alternating current required by the driving coil unit according to the control signal; the parameters comprise wave forms and frequencies;
and combining the parameters, reducing the voltage of the first alternating current input voltage transformer, inputting the first alternating current input voltage into a rectification circuit for rectification, reducing the current variation amplitude of periodic variation through a wave filtering circuit, finally inputting the first alternating current into a voltage stabilizing circuit to obtain standard direct current, and obtaining pulses with voltage, frequency and waveform required by equipment through pulse width modulation to serve as second alternating current.
In some preferred embodiments, the signal preprocessing module comprises a band-stop notch filter, a signal amplifying circuit and a filtering circuit;
the band-elimination notch filter is configured to screen the frequency of the first voltage signal and attenuate the first voltage signal within a set frequency range;
the signal amplification circuit is configured to amplify the first voltage signal through weak signal measurement;
the filter circuit is configured to remove the first voltage signal below a set signal-to-noise ratio threshold.
In some preferred embodiments, the control, signal processing and visualization module completes the input of the control signal and the processing and visualization of the second voltage signal through an upper computer; the upper computer comprises a single chip microcomputer device and a remote computer;
the single chip microcomputer device is used for setting device parameters and sending the second voltage signal to the remote computer;
the remote computer is used for processing the second voltage signal and visualizing the processed second voltage signal through a visualization algorithm integrated with dynamic nonlinear magnetic field response; the remote computer is configured with CPU multithreading and GPU hardware and is used for accelerating the visualization algorithm;
the single chip microcomputer device and the remote computer receive and transmit signals through wireless communication, and both have a display function.
In a second aspect of the present invention, a handheld breast tumor detection method based on magnetic particle imaging is provided, the method comprising:
s100, injecting magnetic particles targeting breast tumor cells or cell molecules into a to-be-detected part of a target object; converting the first alternating current into a second alternating current based on control signals of alternating currents required by modules in the handheld breast tumor detection device based on magnetic particle imaging;
s200, inputting the second alternating current into the coil module to construct a driving field, enabling the coil module to be close to the part to be detected of the target object, moving the coil module according to requirements, and collecting magnetic particle imaging voltage signals as first voltage signals;
s300, inputting the first voltage signal into the signal preprocessing module for preprocessing to obtain a second voltage signal;
and S400, inputting the second voltage signal into the control, signal processing and visualization module for processing and visualization to obtain a magnetic particle imaging result of the part to be detected of the target object.
In a third aspect of the present specification, an electronic device is presented, at least one processor; and a memory communicatively coupled to at least one of the processors, wherein the memory stores instructions executable by the processors for execution by the processors to implement the magnetic particle imaging-based handheld breast tumor detection apparatus described above.
In a fourth aspect of the present specification, a computer-readable storage medium is provided, which stores computer instructions for being executed by the computer to implement the above-mentioned handheld breast tumor detection apparatus based on magnetic particle imaging.
The invention has the beneficial effects that:
the breast tumor detection device is smaller in size, convenient and fast to detect in a handheld mode, improves the breast tumor detection sensitivity, reduces the difficulty in interpreting the breast tumor, and is more beneficial to treatment of the breast tumor.
1) The invention provides a handheld breast tumor detection device based on magnetic particle imaging, which is small in size and avoids the defects of large equipment size, high specialization degree and the like in the traditional tumor detection method;
2) The invention optimizes the circuit design and improves the sensitivity perception of the nonlinear response signal of the magnetic nano particles and the sensitivity of breast tumor detection;
3) According to the invention, magnetic particle imaging signals are acquired through the coil sensor, converted into voltage signals and processed, and the detection result is visualized through the hardware and software design of the upper computer, so that the difficulty in interpretation of breast tumors is reduced;
4) The invention is based on a new biomedical imaging modality of magnetic particle imaging, realizes the detection of the breast tumor through hardware and software design, has the advantages of high sensitivity, high time resolution, safety, no radiation and the like, can realize handheld convenient detection, can effectively solve the limitations of large equipment volume, high specialization degree and the like when conventional equipment such as CT imaging, X-ray tomography, nuclear magnetic resonance and the like carries out tumor detection, provides more convenient detection means, realizes the early discovery of the breast tumor, guides the selection of a treatment scheme in clinical practice and improves the treatment effect of the breast tumor.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments made with reference to the accompanying drawings in which:
FIG. 1 is a schematic diagram of a mechanical auxiliary module of a handheld breast tumor detection device based on magnetic particle imaging according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a coil module of a handheld breast tumor detection device based on magnetic particle imaging according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a frame of a handheld breast tumor detection device based on magnetic particle imaging according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of the hardware and software design of the upper computer of the handheld breast tumor detection device based on magnetic particle imaging according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of the use of a handheld breast tumor detection device based on magnetic particle imaging in accordance with one embodiment of the present invention;
FIG. 6 is a schematic diagram of the detection result of the handheld breast tumor detection device based on magnetic particle imaging according to an embodiment of the present invention;
FIG. 7 is a flow chart of a hand-held breast tumor detection method based on magnetic particle imaging according to an embodiment of the present invention;
fig. 8 is a schematic structural diagram of a computer system suitable for implementing an electronic device according to an embodiment of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the related invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
The invention provides a hand-held breast tumor detection device based on magnetic particle imaging, which comprises:
the coil module comprises a plurality of groups of coil probes arranged in parallel; the coil probe comprises a driving coil unit, a receiving coil unit and a compensating coil unit;
the driving coil unit comprises a driving coil wound on the outer surface of the first cylinder; the first cylinder is a hollow cylinder; the driving coil unit is configured to construct a driving field to enable the magnetic particles to generate nonlinear response;
the receiving coil unit comprises a receiving coil wound at one end of the outer surface of the second cylinder; the second cylinder is positioned inside the first cylinder, and the second cylinder is coaxial with the first cylinder; the receiving coil unit is configured to convert the change of the magnetic field caused by the nonlinear response into a voltage signal as a first voltage signal;
the compensating coil unit comprises a compensating coil wound at the other end of the outer surface of the second cylinder; the compensation coil unit is configured to collect magnetic field information and compensate the receiving coil;
the mechanical auxiliary module comprises a coil fixing device, device fixing equipment and a hand-held mechanical arm;
the coil fixing device is arranged at one end close to the compensation coil; the coil fixing device is configured to fix each coil in the coil module and maintain the relative position of the coils;
the handheld mechanical arm is a multi-degree-of-freedom mechanical arm, one end of the handheld mechanical arm is connected with the device fixing equipment, and the other end of the handheld mechanical arm is connected with the coil fixing device; the handheld mechanical arm is configured to move and rotate the coil module and the coil fixing device;
the device fixing equipment is of a box structure and is connected with the tail end of the hand mechanical arm; the device fixing equipment is used for fixing the mechanical arm device;
the signal preprocessing module is configured to preprocess the first voltage signal to obtain a second voltage signal;
and the control, signal processing and visualization module is configured to control the current change of a driving coil in the coil module according to a set control instruction, so as to realize the scanning imaging of the target to be detected.
In order to more clearly describe the handheld breast tumor detection device based on magnetic particle imaging of the present invention, the following describes each module in the embodiment of the device in detail with reference to the accompanying drawings.
A handheld breast tumor detection device based on magnetic particle imaging, as shown in fig. 3, the device comprising: the system comprises a coil module 100, a power supply module 200, a mechanical auxiliary module 300, a signal preprocessing module 400 and a control, signal processing and visualization module 500;
the coil module 100, as shown in fig. 2, includes a plurality of sets of coil probes arranged in parallel; the coil probe comprises a driving coil unit, a receiving coil unit and a compensating coil unit; configured to perform signal detection at a plurality of locations; the coil module is configured to establish a driving field and realize acquisition of magnetic particle imaging signals by designing a driving coil, a receiving coil and other matched coils;
the driving coil unit comprises a driving coil wound on the outer surface of the first cylinder; the first cylinder is a hollow cylinder, and the cross section of the first cylinder is preferably circular; the driving coil unit is configured to introduce alternating current into a driving coil to construct a driving field, and the magnetic field of the driving field changes along with time to enable the magnetic particles to generate nonlinear response;
in this embodiment, the alternating current is preferably a square wave pulse of 25kHz, and the nonlinear response is expressed by the langevin equation:
(ii) a Wherein +>
Is averaged moment->
For a distribution of magnetic particles>
Is a unit direction vector>
Is a function of the boy>
Is a proportionality factor>
Is the magnetic field strength of the drive field.
The receiving coil unit comprises a receiving coil wound on one end of the outer surface of the second cylinder; the second cylinder is positioned inside the first cylinder, and the second cylinder is coaxial with the first cylinder; the receiving coil unit is configured to convert the change of the magnetic field caused by the nonlinear response into a voltage signal as a first voltage signal;
the compensation coil unit comprises a compensation coil wound at the other end of the outer surface of the second cylinder; the compensation coil unit is configured to acquire magnetic field information and compensate the receiving coil;
through the design of the coil module circuit, high-sensitivity sensing of the nonlinear response signal of the magnetic nanoparticles is realized.
The power supply module 200 comprises a voltage transformer, a frequency conversion circuit, a filter circuit and a voltage stabilizing circuit; the power supply module is configured to convert a first alternating current into a second alternating current according to a control signal and input the second alternating current into a driving coil in the coil module; the first alternating current is the alternating current input by the handheld breast tumor detection device based on magnetic particle imaging;
in the embodiment, control signals of alternating current needed by each module in the handheld breast tumor detection device based on magnetic particle imaging are received; reading parameters of the alternating current required by the driving coil unit according to the control signal; the parameters comprise wave forms and frequencies;
the method for converting the first alternating current into the second alternating current comprises the following steps: and finally, inputting the voltage stabilizing circuit to obtain standard direct current, and obtaining square wave pulses with voltage, frequency and waveform required by equipment as second alternating current through pulse width modulation.
A mechanical assistance module 300, as shown in fig. 1, including a coil fixture, a hand-held robotic arm, a fixture, and a coil cooling apparatus;
the coil fixing device is arranged at one end close to the compensation coil; the coil fixing device is configured to fix each coil in the coil module and keep the relative position of the coils so as to avoid the change of a magnetic field caused by the handheld movement of the equipment and improve the reliability of the equipment;
the handheld mechanical arm is a multi-degree-of-freedom mechanical arm, one end of the handheld mechanical arm is connected with the device fixing equipment, and the other end of the handheld mechanical arm is connected with the coil fixing device; the handheld mechanical arm is configured to move and rotate the coil module and the coil fixing device, and is used for carrying out multi-position and multi-angle detection on the breast tumor;
the device fixing equipment is of a box structure, is connected with the tail end of the hand-held mechanical arm, is used for fixing the hand-held mechanical arm, and is also used for installing hardware equipment of a control module in the power supply module, the signal preprocessing module and the control, signal processing and visualization module and single chip equipment of the signal processing and visualization module;
the coil cooling device is a thin tube wound outside the driving coil and circularly filled with water during working; the coil generates heat when working, and the change of temperature can cause the accuracy of the collected signals to be reduced, so that a coil cooling device is arranged for cooling the heat generated when the driving coil works, and the influence of heating of the electrified coil on tumor detection is avoided;
the signal preprocessing module 400 is configured to preprocess the first voltage signal to obtain a second voltage signal, so as to reduce the processing load of the upper computer;
in this embodiment, the signal preprocessing module includes a band-stop notch filter, a signal amplifying circuit, and a filter circuit;
the band-elimination notch filter is configured to screen the frequency of the first voltage signal and attenuate the first voltage signal within a set frequency range so as to reduce the influence of noise, background signals and the like on setting sensitivity;
the signal amplification circuit is configured to amplify the first voltage signal through weak signal measurement;
the filter circuit is configured to remove the first voltage signal lower than a set signal-to-noise ratio threshold value, and the signal transmission and processing cost is reduced.
The control, signal processing and visualization module 500 is configured to control current change of a driving coil in the coil module and hydraulic pressure of a coil cooling device according to a set control instruction, so as to scan and image a target to be detected.
In this embodiment, as shown in fig. 4, the control, signal processing and visualization module completes the input of the control signal and the processing and visualization of the second voltage signal through an upper computer; the upper computer comprises a single chip microcomputer device and a remote computer;
the single chip microcomputer device is used for setting device parameters and sending the second voltage signal to the remote computer;
the remote computer is used for processing the second voltage signal and visualizing the processed second voltage signal through a visualization algorithm integrated with dynamic nonlinear magnetic field response; the remote computer is configured with CPU multithreading and GPU hardware and is used for accelerating the visualization algorithm;
the single chip microcomputer device and the remote computer receive and transmit signals through wireless communication, and both have a display function.
It should be noted that, the handheld breast tumor detection device based on magnetic particle imaging provided in the foregoing embodiment is only illustrated by dividing the functional modules, and in practical applications, the functions may be allocated to different functional modules according to needs, that is, the modules or steps in the embodiments of the present invention are further decomposed or combined, for example, the modules in the embodiments may be combined into one module, or further split into multiple sub-modules, so as to complete all or part of the functions described above. The names of the modules and steps involved in the embodiments of the present invention are only for distinguishing the modules or steps, and are not to be construed as unduly limiting the present invention.
A second embodiment of the present invention relates to a handheld breast tumor detection method based on magnetic particle imaging, as shown in fig. 7, the method includes:
s100, injecting magnetic particles targeting breast tumor cells or cell molecules into a to-be-detected part of a target object; converting the first alternating current into a second alternating current based on control signals of alternating currents required by modules in the handheld breast tumor detection device based on magnetic particle imaging;
in this embodiment, the first alternating current is an alternating current input by the handheld breast tumor detection device based on magnetic particle imaging; converting the first alternating current into a second alternating current, wherein the method comprises the following steps:
receiving control signals of alternating current needed by each module in the handheld breast tumor detection device based on magnetic particle imaging; reading parameters of the alternating current required by the driving coil unit according to the control signal; the parameters comprise wave forms and frequencies;
and finally, inputting the voltage stabilizing circuit to obtain standard direct current, and obtaining square wave pulses with voltage, frequency and waveform required by equipment as second alternating current through pulse width modulation.
S200, inputting the second alternating current into the coil module to construct a driving field, enabling the coil module to be close to the part to be detected of the target object, moving the coil module according to requirements, and collecting magnetic particle imaging voltage signals as first voltage signals;
in this embodiment, the coil module includes a plurality of sets of coil probes arranged in parallel; the coil probe comprises a driving coil unit, a receiving coil unit and a compensating coil unit; configured to perform signal detection at a plurality of locations;
the driving coil unit comprises a driving coil wound on the outer surface of the first cylinder; the first cylinder is a hollow cylinder; the driving coil unit is configured to introduce alternating current into a driving coil to construct a driving field, and the magnetic field of the driving field changes along with time to enable the magnetic particles to generate nonlinear response;
alternating current is preferably a square wave pulse of 25kHz, and the nonlinear response is expressed by the langevin equation:
The receiving coil unit comprises a receiving coil wound at one end of the outer surface of the second cylinder; the second cylinder is positioned inside the first cylinder, and the second cylinder is coaxial with the first cylinder; the receiving coil unit is configured to convert the change of the magnetic field caused by the nonlinear response into a voltage signal as a first voltage signal;
the compensation coil unit comprises a compensation coil wound at the other end of the outer surface of the second cylinder; the compensation coil unit is configured to be used for acquiring magnetic field information and compensating the receiving coil.
S300, inputting the first voltage signal into the signal preprocessing module for preprocessing to obtain a second voltage signal;
in this embodiment, the signal preprocessing module includes a band-stop notch filter, a signal amplifying circuit and a filter circuit;
the band-elimination notch filter is configured to screen the frequency of the first voltage signal and attenuate the first voltage signal within a set frequency range so as to reduce the influence of noise, background signals and the like on setting sensitivity;
the signal amplification circuit is configured to amplify the first voltage signal through weak signal measurement;
the filter circuit is configured to remove the first voltage signal lower than a set signal-to-noise ratio threshold value, and the signal transmission and processing cost is reduced.
And S400, inputting the second voltage signal into the control, signal processing and visualization module for processing and visualization to obtain a magnetic particle imaging result of the part to be detected of the target object.
In this embodiment, a mammary gland phantom model is used as a target, and the tracer particles injected into the phantom are superparamagnetic iron oxide (SPIO).
The control, signal processing and visualization module completes the input of a control signal and the processing and visualization of the second voltage signal through an upper computer;
the upper computer comprises a single chip microcomputer device and a remote computer; the single chip microcomputer device is used for setting device parameters and sending the second voltage signal to the remote computer;
the remote computer is used for processing the second voltage signal and visualizing the processed second voltage signal through a visualization algorithm integrated with dynamic nonlinear magnetic field response; the remote computer is configured with CPU multithreading and GPU hardware and is used for accelerating the visualization algorithm;
the single chip microcomputer device and the remote computer receive and transmit signals through wireless communication, and both have a display function;
and observing a detection result on a display screen of the upper computer hardware, wherein the detection result is shown in fig. 6.
An electronic device according to a third embodiment of the present invention includes at least one processor; and a memory communicatively coupled to at least one of the processors, wherein the memory stores instructions executable by the processors for execution by the processors to implement the magnetic particle imaging-based handheld breast tumor detection apparatus described above.
A computer-readable storage medium of a fourth embodiment of the present invention stores computer instructions for execution by the computer to implement the above-mentioned handheld breast tumor detection apparatus based on magnetic particle imaging.
It can be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working processes and related descriptions of the electronic device and the computer-readable storage medium described above may refer to corresponding processes in the foregoing method examples, and are not described herein again.
Referring now to FIG. 8, there is illustrated a block diagram of a computer system suitable for use as a server in implementing embodiments of the method, system, and apparatus of the present application. The server shown in fig. 8 is only an example, and should not bring any limitation to the functions and the scope of use of the embodiments of the present application.
As shown in fig. 8, the computer system includes a Central Processing Unit (CPU) 801 that can perform various appropriate actions and processes according to a program stored in a Read Only Memory (ROM) 802 or a program loaded from a storage section 808 into a Random Access Memory (RAM) 803. In the RAM 803, various programs and data necessary for system operation are also stored. The CPU 801, ROM802, and RAM 803 are connected to each other via a bus 804. An Input/Output (I/O) interface 805 is also connected to the bus 804.
The following components are connected to the I/O interface 805: an input portion 806 including a keyboard, a mouse, and the like; an output section 807 including a Cathode Ray Tube (CRT), a Liquid Crystal Display (LCD), and a speaker; a storage portion 808 including a hard disk and the like; and a communication section 809 including a Network interface card such as a LAN (Local Area Network) card, a modem, and the like. The communication section 809 performs communication processing via a network such as the internet. A drive 810 is also connected to the I/O interface 805 as necessary. A removable medium 811 such as a magnetic disk, an optical disk, a magneto-optical disk, a semiconductor memory, or the like is mounted on the drive 810 as necessary, so that a computer program read out therefrom is mounted on the storage section 808 as necessary.
In particular, according to an embodiment of the present invention, the processes described above with reference to the flowcharts may be implemented as computer software programs. For example, embodiments of the invention include a computer program product comprising a computer program embodied on a computer-readable medium, the computer program comprising program code for performing the method illustrated in the flow chart. In such an embodiment, the computer program may be downloaded and installed from a network through the communication section 809 and/or installed from the removable medium 811. The computer program performs the above-described functions defined in the method of the present application when executed by the Central Processing Unit (CPU) 801. It should be noted that the computer readable medium mentioned above in the present application may be a computer readable signal medium or a computer readable storage medium or any combination of the two. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples of the computer readable storage medium may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this application, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: wireless, wire, fiber optic cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present application may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, smalltalk, C + +, and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems that perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The terms "first," "second," and the like are used for distinguishing between similar elements and not necessarily for describing or implying a particular order or sequence.
The terms "comprises," "comprising," or any other similar term are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
So far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the accompanying drawings.
The above description is only an example of the present application and is not intended to limit the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.
Claims (10)
1. A handheld breast tumor detection device based on magnetic particle imaging, the device comprising:
the coil module comprises a plurality of groups of coil probes arranged in parallel; the coil probe comprises a driving coil unit, a receiving coil unit and a compensating coil unit;
the driving coil unit comprises a driving coil wound on the outer surface of the first cylinder; the first cylinder is a hollow cylinder; the driving coil unit is configured to construct a driving field to enable the magnetic particles to generate nonlinear response;
the receiving coil unit comprises a receiving coil wound at one end of the outer surface of the second cylinder; the second cylinder is positioned inside the first cylinder, and the second cylinder is coaxial with the first cylinder; the receiving coil unit is configured to convert the change of the magnetic field caused by the nonlinear response into a voltage signal as a first voltage signal;
the compensation coil unit comprises a compensation coil wound at the other end of the outer surface of the second cylinder; the compensation coil unit is configured to collect magnetic field information and compensate the receiving coil;
the mechanical auxiliary module comprises a coil fixing device, device fixing equipment and a hand-held mechanical arm;
the coil fixing device is arranged at one end close to the compensation coil; the coil fixing device is configured to fix each coil in the coil module and maintain the relative position of the coils;
the handheld mechanical arm is a multi-degree-of-freedom mechanical arm, one end of the handheld mechanical arm is connected with the device fixing equipment, and the other end of the handheld mechanical arm is connected with the coil fixing device; the handheld mechanical arm is configured to move and rotate the coil module and the coil fixing device;
the device fixing equipment is of a box structure and is connected with the tail end of the hand mechanical arm; the device fixing equipment is used for fixing the handheld mechanical arm;
the signal preprocessing module is configured to preprocess the first voltage signal to obtain a second voltage signal;
the control, signal processing and visualization module is configured to control current change of a driving coil in the coil module according to a set control instruction, so as to realize scanning imaging of a target to be detected.
2. The magnetic particle imaging-based handheld breast tumor detection device of claim 1, further comprising a power supply module; the mechanical auxiliary module also comprises a coil cooling device;
the power supply module comprises a voltage transformer, a frequency conversion circuit, a filter circuit and a voltage stabilizing circuit; the power supply module is configured to convert a first alternating current into a second alternating current according to a control signal and input the second alternating current into a driving coil in the coil module; the first alternating current is the alternating current input by the handheld breast tumor detection device based on magnetic particle imaging;
the coil cooling device is a thin tube wound outside the driving coil; and the coil cooling device is used for cooling heat generated when the driving coil works.
3. The magnetic particle imaging-based handheld breast tumor detection device of claim 1, wherein the device fixing apparatus is further configured to install a hardware device of the power supply module, the signal preprocessing module and a control module of the control, signal processing and visualization module, and a single chip device of the signal processing and visualization module.
4. The magnetic particle imaging-based handheld breast tumor detection device of claim 1, wherein the nonlinear response is expressed by the langevin equation:
5. The device of claim 1, wherein the first AC power is converted to a second AC power by a method comprising;
receiving control signals of alternating current needed by each module in the handheld breast tumor detection device based on magnetic particle imaging; reading parameters of the alternating current required by the driving coil unit according to the control signal; the parameters comprise wave forms and frequencies;
and finally, inputting the voltage stabilizing circuit to obtain standard direct current, and obtaining pulses of voltage, frequency and waveform required by equipment as second alternating current through pulse width modulation.
6. The handheld breast tumor detection device based on magnetic particle imaging of claim 1, wherein the signal preprocessing module comprises a band-stop notch filter, a signal amplifying circuit and a filter circuit;
the band-elimination notch filter is configured to screen the frequency of the first voltage signal and attenuate the first voltage signal within a set frequency range;
the signal amplification circuit is configured to amplify the first voltage signal through weak signal measurement;
the filter circuit is configured to remove the first voltage signal below a set signal-to-noise ratio threshold.
7. The handheld breast tumor detection device based on magnetic particle imaging of claim 1, wherein the control, signal processing and visualization module completes the input of the control signal and the processing and visualization of the second voltage signal through an upper computer;
the upper computer comprises a single chip microcomputer device and a remote computer;
the single chip microcomputer device is used for setting device parameters and sending the second voltage signal to the remote computer;
the remote computer is used for processing the second voltage signal and visualizing the processed second voltage signal through a visualization algorithm integrated with dynamic nonlinear magnetic field response; the remote computer is provided with CPU multithreading and GPU hardware and is used for accelerating the visualization algorithm;
the single chip microcomputer device and the remote computer receive and transmit signals through wireless communication, and both have a display function.
8. A handheld breast tumor detection method based on magnetic particle imaging, which is based on the handheld breast tumor detection device based on magnetic particle imaging of any one of claims 1 to 7, and is characterized in that the method comprises the following steps:
s100, injecting magnetic particles targeting breast tumor cells or cell molecules into a to-be-detected part of a target object; converting the first alternating current into a second alternating current based on control signals of alternating currents required by modules in the handheld breast tumor detection device based on magnetic particle imaging;
s200, inputting the second alternating current into the coil module to construct a driving field, enabling the coil module to be close to the part to be detected of the target object, moving the coil module according to requirements, and collecting magnetic particle imaging voltage signals as first voltage signals;
s300, inputting the first voltage signal into the signal preprocessing module for preprocessing to obtain a second voltage signal;
and S400, inputting the second voltage signal into the control, signal processing and visualization module for processing and visualization to obtain a magnetic particle imaging result of the part to be detected of the target object.
9. An electronic device, comprising:
at least one processor; and a memory communicatively coupled to at least one of the processors;
wherein the memory stores instructions executable by the processor for execution by the processor to implement the magnetic particle imaging-based handheld breast tumor detection method of claim 8.
10. A computer readable storage medium storing computer instructions for execution by the computer to implement the magnetic particle imaging-based handheld breast tumor detection method of claim 8.
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