CN113331812A - Whole body-oriented three-dimensional magnetic particle imaging method, system and equipment - Google Patents
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Abstract
The invention belongs to the technical field of magnetic particle imaging, and particularly relates to a whole-body-oriented three-dimensional magnetic particle imaging method, system and equipment, aiming at solving the problem that the magnetic particle imaging cannot be carried out simultaneously on the whole body. The array type magnetic particle imaging system is formed by coupling a single set of magnetic particle imaging systems, and the imaging visual field is expanded from a local area to a whole size. In the signal acquisition process, each group of magnet exciting and receiving coils in the whole-body magnetic particle imaging system are synchronized, denoising and filtering amplification are carried out on the obtained electromagnetic induction signals, image reconstruction is carried out by utilizing a deconvolution or regularization method, reconstructed images in all imaging visual fields are spliced, and finally three-dimensional distribution images of magnetic particles in the whole body are obtained, so that whole-body imaging of an observed object is realized, and higher inspection and diagnosis accuracy is achieved.
Description
Technical Field
The invention belongs to the technical field of magnetic particle imaging, and particularly relates to a three-dimensional magnetic particle imaging method, system and equipment for the whole body.
Background
In biomedical imaging detection, the non-invasive observation of the anatomical structure, functional metabolism and molecular cell activity of a living organism in the living organism is always a leading research hotspot and development direction. Existing medical imaging technologies such as CT, MRI, SPECT, optics, etc. have respective technical and application bottlenecks, such as optical imaging limited by imaging depth, magnetic resonance imaging limited by imaging sensitivity, nuclide imaging limited by ionizing radiation and imaging resolution. Therefore, a new imaging technology with the characteristics of large depth, high sensitivity, no radiation and the like is needed to meet the requirements of in vivo imaging and accurate quantitative observation of tumors and lesions at the molecular cell level.
In recent years, a novel imaging mode based on superparamagnetic iron oxide nanoparticles (SPIONs), namely, Magnetic Particle Imaging (MPI), has been proposed. The technology utilizes the principle of non-linear response remagnetization of magnetic nanoparticles in a non-magnetic field space in a high-gradient magnetic field to obtain the three-dimensional concentration distribution of the magnetic nanoparticles in a living body in a high-sensitivity and quantitative manner, and has the characteristics of three-dimensional imaging, high space-time resolution and high sensitivity. In addition, MPI does not show anatomical structures and is free of background signal interference, so the intensity of the signal is directly proportional to the concentration of the tracer, which is a new imaging method with potential for medical applications.
Most of the current MPI systems are configured to have a Field Free Region (FFR), i.e., a Field Free Point (FFP) or a Field Free Line (FFL), receive a magnetization response signal of magnetic nanoparticles in the FFR Region through a high-sensitivity coil, spatially encode a FFR scanning track, and reconstruct an image based on the spatial encoding. However, since MPI imaging requires a high gradient field to ensure that the magnetic nanoparticles are in a magnetic saturation state outside the FFR, the MPI imaging field of view is usually less than ten and several centimeters, which cannot satisfy the whole-body dimension field of view imaging, especially for large-size imaging objects. Based on the method, the invention provides a whole-body-oriented three-dimensional magnetic particle imaging method and a whole-body-oriented three-dimensional magnetic particle imaging system, wherein a single group of magnetic particle imaging systems are coupled to form an array type magnetic particle imaging system, the imaging visual field is expanded from local to whole-body size, and electromagnetic shielding is arranged between magnets generating FFR and moving FFR in each group; and synchronously acquiring the magnet exciting and acquiring coils of each group of magnetic particle imaging systems by adopting a synchronous clock, and after denoising the obtained electromagnetic induction signals, reconstructing the images by utilizing a deconvolution or regularization method to finally obtain the three-dimensional distribution images of the magnetic particles on the whole body, thereby realizing the whole-body imaging of the region of interest.
Disclosure of Invention
In order to solve the above-mentioned problems in the prior art, that is, to solve the problem in the prior art that magnetic particle imaging cannot be performed simultaneously on the whole body, in a first aspect of the present invention, a three-dimensional magnetic particle imaging method for the whole body is provided, the method including the steps of:
step S100, constructing an MPI imaging system according to the size of a measured object, wherein the MPI imaging system comprises a plurality of MPI imaging units and a controller which are coaxially arranged along the length direction of the measured object, and each MPI imaging unit is respectively in communication connection with the controller through a communication link;
step S200, after the object to be detected enters an imaging cabin of the MPI imaging system, the controller changes the position of the magnetic field-free area of each MPI imaging unit by respectively adjusting the electromagnetic magnetic field intensity of each MPI imaging unit, so that each magnetic field-free area respectively scans the target field of each MPI imaging unit along a preset track;
step S300, acquiring a first data signal generated by the change of the induced voltage in each target field along with time;
step S400, filtering each first data signal respectively, removing interference signals and noise signals generated by a driving coil in an MPI imaging unit, and amplifying the filtered data signals to obtain second data signals;
step S500, converting the second data signal from a time domain to a frequency domain, and respectively reconstructing a three-dimensional image based on a preset processing method to obtain a plurality of reconstructed image blocks;
and S600, splicing the reconstruction image blocks according to the relative position relation among the reconstruction image blocks to obtain a three-dimensional reconstruction result of the whole body size of the measured object.
In some preferred technical solutions, the MPI imaging unit includes three sets of electromagnetic coil pairs and a receiving coil set, which are coaxially arranged at intervals, the three sets of electromagnetic coil pairs are respectively distributed along three orthogonal directions, axes of the three sets of electromagnetic coil pairs intersect at a point, the point is taken as an origin, axes of the three sets of electromagnetic coil pairs are respectively an x axis, a y axis and a z axis, the receiving coil set is a pair of annular induction coils, and the pair of annular induction coils are respectively arranged in parallel at an outer side of any set of electromagnetic coil pairs; the controller is in communication connection with the set of receive coils to acquire the current signals generated thereby.
In some preferred technical solutions, the MPI imaging unit further includes a cylindrical magnet, the cylindrical magnet is disposed in the enclosed space of the three sets of electromagnetic coil pairs, the cylindrical magnet has a receiving space, the receiving spaces of the cylindrical magnets together form an imaging cabin of the MPI imaging system, and the imaging cabin is used for receiving and carrying the object to be measured.
In some preferred technical solutions, the MPI imaging system further includes an imaging couch and an imaging couch moving device, the imaging couch is configured to carry a measured object, and the controller controls the imaging couch moving device to drive the imaging couch to drive the measured object to enter an imaging cabin of the MPI imaging system.
In some preferred embodiments, the method of "acquiring the first data signal generated by the induced voltage varying with time in each target field" in step S300 is acquired by the receiving coil set.
In some preferred technical solutions, the preset processing method is a deconvolution or regularization method.
In a second aspect of the present invention, a three-dimensional magnetic particle imaging system for the whole body is provided, the system includes a plurality of coaxially disposed MPI imaging units, an imaging bed and an electronic control unit, the electronic control unit is respectively connected to each MPI imaging unit through a communication link in a communication manner;
the MPI imaging unit comprises two pairs of electromagnetic coils, a cylindrical magnet, a driving coil group and a receiving coil group; two electromagnetic coils in the electromagnetic coil pair are coaxial, and the axes of the two electromagnetic coil pairs are orthogonal; the cylindrical magnet is arranged in the surrounding space of the two pairs of electromagnetic coils, the axis of the cylindrical magnet passes through the axis orthogonal point of the two pairs of electromagnetic coils and is perpendicular to the plane formed by the axes of the two pairs of electromagnetic coils, and the cylindrical magnet of each MPI imaging unit is coaxially arranged; the driving coil group comprises two driving coils which are coaxially arranged at intervals, and the axis of the driving coil group is orthogonal to the axes of the two pairs of electromagnetic coils; the receiving coil group is a pair of annular induction coils which are respectively arranged on the outer sides of any group of electromagnetic coil pairs in parallel;
the electric control unit is configured to control the two pairs of electromagnetic coils of each MPI imaging unit to construct a gradient magnetic field and form a magnetic field-free area; when the imaging bed enters a set position in the cylindrical magnet, the electric control unit changes the electromagnetic field intensity of the MPI imaging unit according to a set control instruction to change the position of a magnetic field-free area, so that the MPI imaging unit respectively scans the target field of each MPI imaging unit along a preset track, acquires a first data signal generated by the change of induced voltage in each target field along time, respectively filters each first data signal, removes interference signals and noise signals generated by a driving coil in the MPI imaging unit, amplifies the filtered data signal to obtain a second data signal, converts the second data signal from a time domain to a frequency domain, respectively reconstructs three-dimensional images based on a preset processing method to obtain a plurality of reconstructed image blocks, and splices the reconstructed image blocks according to the relative position relationship among the reconstructed image blocks, and acquiring a three-dimensional reconstruction result of the whole body size of the measured object.
In a third aspect of the present invention, an electronic device is provided, including: at least one processor; and a memory communicatively coupled to at least one of the processors; wherein the memory stores instructions executable by the processor for execution by the processor to implement the above-described whole-body-oriented three-dimensional magnetic particle imaging method.
In a fourth aspect of the present invention, a computer-readable storage medium is provided, wherein the computer-readable storage medium stores computer instructions for being executed by the computer to implement the above-mentioned whole-body-oriented three-dimensional magnetic particle imaging method.
The invention has the beneficial effects that:
the array type magnetic particle imaging system is formed by coupling a single set of magnetic particle imaging systems, and the imaging visual field is expanded from a local area to a whole size. In the signal acquisition process, each group of magnet exciting and receiving coils in the whole-body magnetic particle imaging system are synchronized, denoising and filtering amplification are carried out on the obtained electromagnetic induction signals, image reconstruction is carried out by utilizing a deconvolution or regularization method, reconstructed images in all imaging visual fields are spliced, and finally three-dimensional distribution images of magnetic particles in the whole body are obtained, so that whole-body imaging of an observed object is realized, and higher inspection and diagnosis accuracy is achieved.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the following detailed description of non-limiting embodiments thereof, made with reference to the accompanying drawings.
FIG. 1 is a schematic flow chart of a whole-body oriented three-dimensional magnetic particle imaging method according to an embodiment of the present invention;
FIG. 2 is a structural example diagram of a whole-body oriented three-dimensional magnetic particle imaging system according to an embodiment of the present invention;
FIG. 3 is an exemplary diagram of a field-free region and a gradient field generated by an MPI imaging unit of one embodiment of the present invention;
FIG. 4 is a schematic diagram of the operation of a whole-body oriented three-dimensional magnetic particle imaging system in accordance with an embodiment of the present invention;
fig. 5 is a schematic structural diagram of a computer system suitable for implementing an electronic device according to an embodiment of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the related invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The invention relates to a whole-body-oriented three-dimensional magnetic particle imaging method, which comprises the following steps as shown in figure 1:
step S100, constructing an MPI imaging system according to the size of a measured object, wherein the MPI imaging system comprises a plurality of MPI imaging units and a controller which are coaxially arranged along the length direction of the measured object, and each MPI imaging unit is respectively in communication connection with the controller through a communication link;
step S200, after the object to be detected enters an imaging cabin of the MPI imaging system, the controller changes the position of the magnetic field-free area of each MPI imaging unit by respectively adjusting the electromagnetic magnetic field intensity of each MPI imaging unit, so that each magnetic field-free area respectively scans the target field of each MPI imaging unit along a preset track;
step S300, acquiring a first data signal generated by the change of the induced voltage in each target field along with time;
step S400, filtering each first data signal respectively, removing interference signals and noise signals generated by a driving coil in an MPI imaging unit, and amplifying the filtered data signals to obtain second data signals;
step S500, converting the second data signal from a time domain to a frequency domain, and respectively reconstructing a three-dimensional image based on a preset processing method to obtain a plurality of reconstructed image blocks;
and S600, splicing the reconstruction image blocks according to the relative position relation among the reconstruction image blocks to obtain a three-dimensional reconstruction result of the whole body size of the measured object.
The invention establishes a method and a system for imaging magnetic particles with the size facing the whole body. The method is favorable for carrying out overall analysis on the detection target through the whole-body magnetic particle image, and effectively improves the accuracy of diagnosis and detection
In order to more clearly explain the whole-body-oriented three-dimensional magnetic particle imaging method of the present invention, the following describes the steps in the embodiment of the method in detail with reference to the drawings.
And S100, constructing an MPI imaging system according to the size of the measured object. The MPI imaging system comprises a plurality of MPI imaging units and a controller, wherein the MPI imaging units are arranged along the length direction of a measured object, and each MPI imaging unit is in communication connection with the controller through a communication link. Specifically, the MPI imaging unit comprises three groups of electromagnetic coil pairs and a receiving coil group, wherein coils in each group of electromagnetic coil pairs are coaxially arranged at intervals, the three groups of electromagnetic coil pairs are respectively distributed along three orthogonal directions, the axes of the three groups of electromagnetic coil pairs are intersected at one point, the point is taken as an original point 100, the axes of the three groups of electromagnetic coil pairs are respectively an x axis 20, a y axis 30 and a z axis 40, and the receiving coil group is a pair of annular induction coils which are respectively arranged on the outer sides of any group of electromagnetic coil pairs in parallel; the controller is connected with the receiving coil group in a communication mode to acquire the current signal generated by the receiving coil group.
Further, the MPI imaging unit includes two pairs of electromagnetic coils, respectively, a first electromagnetic coil pair 11 and a second electromagnetic coil pair 21, a cylindrical magnet, a driving coil group 31, and a receiving coil group 41 as shown in fig. 2; each electromagnetic coil pair comprises two electromagnetic coils which are coaxial, and the axes of the first electromagnetic coil pair 11 and the second electromagnetic coil pair 21 are orthogonal; the axis of the cylindrical magnet passes through the orthogonal point of the axis of the first electromagnetic coil pair 11 and the axis of the second electromagnetic coil pair 21 and is perpendicular to the plane formed by the axis of the first electromagnetic coil pair 11 and the axis of the second electromagnetic coil pair 21; further, the cylindrical magnets of the respective MPI imaging units in the MPI imaging system are coaxially arranged and communicated with each other; the driving coil group 31 comprises two driving coils which are coaxially arranged at intervals, and the axial line of the driving coil group 31, the axial line of the first electromagnetic coil pair 11 and the axial line of the second electromagnetic coil pair 21 are mutually orthogonal and are mutually intersected at one point; that is, with this point as the origin, the axis of the drive coil group 31 is the x-axis, the axis of the first electromagnetic coil pair 11 is the y-axis, and the axis of the second electromagnetic coil pair 21 is the z-axis; the cylindrical magnet is disposed in the space surrounded by the first electromagnetic coil pair 11, the second electromagnetic coil pair 21, and the driving coil group 31, and the receiving coil group 41 is a pair of toroidal induction coils disposed in parallel on the outer side of the first electromagnetic coil pair 11 or the outer side of the second electromagnetic coil pair 21. Preferably, the present receiver coil group 41 is disposed outside the second electromagnetic coil pair 21.
Further, referring to fig. 2, the MPI imaging system of the present application includes a plurality of MPI imaging units arranged in parallel, that is, the first electromagnetic coil pairs of the MPI imaging units are respectively arranged in parallel at intervals, and the second electromagnetic coil pairs of the MPI imaging units are connected to each other, and the receiving coil groups are a group and arranged at two ends of the second electromagnetic coil pairs of the overall MPI forming system. The cylindrical magnets are provided with accommodating spaces, and the accommodating spaces of the cylindrical magnets jointly form an imaging cabin of the MPI imaging system, and the imaging cabin is used for accommodating and carrying a measured object. The MPI imaging unit selects a gradient magnetic field 80 through the components of the first electromagnetic coil pair 11 and the second electromagnetic coil pair 21, and forms a magnetic field free region 81, namely an FFR region, and particularly refers to FIG. 3. Note that the field-free region 81 is located inside the imaging chamber.
Step S200, after the object to be tested enters an imaging cabin of the MPI imaging system, the controller respectively adjusts the electromagnetic field intensity of each MPI imaging unit to change the position of a magnetic field-free area of each MPI imaging unit, so that each magnetic field-free area respectively scans the target field 50, namely FOV, of each MPI imaging unit along a preset track;
specifically, referring to fig. 4, the system of the present application further includes an imaging bed 310 and an imaging bed moving device, the imaging bed 310 is used for carrying the object 300, and the controller 320 drives the imaging bed 310 to drive the object 300 into the imaging cabin of the MPI imaging system by controlling the imaging bed moving device.
Step S300, acquiring a first data signal generated by the variation of the induction voltage in each target field 50 along with time; preferably, the acquiring of the first data signal is performed by the receiving coil set 41, and each MPI imaging unit simultaneously and respectively acquires the first data signal in the respective target field and then sends the first data signal to the controller.
Step S400, filtering each first data signal through a controller respectively, removing interference signals generated by a driving coil and noise signals generated by the coil in an MPI imaging unit, and amplifying the filtered data signals to obtain second data signals;
step S500, converting the acquired second data signal from a time domain to a frequency domain, and respectively reconstructing a three-dimensional image based on a preset processing method to obtain a plurality of reconstructed image blocks; in some preferred embodiments, the predetermined processing method is a deconvolution or regularization method. Preferably, the present application adopts a system matrix method, i.e., a least square form based on regularization method constraint, and mine (x) | | Ax-b | + lambda | | x | | approaches the optimal solution.
The deconvolution method is wiener filtering (winner Filter), that is, the least square is used as the optimal solution, and the least square method is used to realize the optimization, which is a common filtering method. In the preferred embodiment of the present application, the target function of deconvolution is the PSF function of the magnetic nanoparticles, which is generally considered to be approximated by the derivative of the langevin function, which is expressed by the formula M (H) ═ 1/H ^2-1/sinh (H) ^ 2.
And S600, performing three-dimensional reconstruction on signals in each group of coil target fields by a parallel computing method, and finally obtaining a final three-dimensional reconstruction result of the whole body size by an image splicing method. Specifically, the reconstructed image blocks are spliced according to the relative position relationship between the reconstructed image blocks, and a three-dimensional reconstruction result 330 of the whole body size of the object to be measured is obtained.
The whole body-oriented three-dimensional magnetic particle imaging system of the second embodiment of the invention comprises a plurality of coaxially arranged MPI imaging units, an imaging bed and an electric control unit, wherein the electric control unit is respectively in communication connection with the MPI imaging units through communication links;
the MPI imaging unit comprises two pairs of electromagnetic coils, a cylindrical magnet, a driving coil group and a receiving coil group; two electromagnetic coils in the electromagnetic coil pair are coaxial, and the axes of the two electromagnetic coil pairs are orthogonal; the cylindrical magnet is arranged in the surrounding space of the two pairs of electromagnetic coils, the axis of the cylindrical magnet passes through the axis orthogonal point of the two pairs of electromagnetic coils and is perpendicular to the plane formed by the axes of the two pairs of electromagnetic coils, and the cylindrical magnet of each MPI imaging unit is coaxially arranged; the driving coil group comprises two driving coils which are coaxially arranged at intervals, the axis of the driving coil group is orthogonal to the axes of the two pairs of electromagnetic coils, and the axis of the driving coil group passes through the orthogonal points of the axes of the two pairs of electromagnetic coils; the receiving coil group is a pair of annular induction coils which are respectively arranged on the outer sides of any group of electromagnetic coil pairs in parallel; preferably, the MPI imaging unit in the whole-body-oriented three-dimensional magnetic particle imaging system of this embodiment is the MPI imaging unit in the above-mentioned embodiment, and the electronic control unit of this application is the controller in the above-mentioned embodiment.
The electric control unit is configured to control the two pairs of electromagnetic coils of each MPI imaging unit to construct a gradient magnetic field and form a magnetic field-free area; when the imaging bed enters a set position in the cylindrical magnet, the electric control unit changes the electromagnetic field intensity of the MPI imaging units according to a set control instruction so as to change the position of the magnetic field-free area, so that the MPI imaging units respectively scan the target Field (FOV) of each MPI imaging unit along a preset track, and acquiring first data signals generated by the variation of the induced voltage in each target field along with time, respectively filtering each first data signal, removing interference signals and noise signals generated by a driving coil in an MPI imaging unit, amplifying the filtered data signal to obtain a second data signal, converting the second data signal from time domain to frequency domain, and respectively reconstructing the three-dimensional image based on a preset processing method to obtain a plurality of reconstructed image blocks, and according to the relative position relationship among the reconstructed image blocks, and splicing the reconstructed image blocks to obtain a three-dimensional reconstruction result of the whole body size of the measured object. The preset processing method is a deconvolution or regularization method. Fig. 4 is a schematic diagram of an exemplary three-dimensional magnetic particle imaging system for the whole body according to the present application, in which the present embodiment can be flexibly set according to the size of the measured object, specifically, the total length of the measured object and the length of the target field FOV of each MPI imaging unit can obtain the number of MPI imaging units required by the present system, and the working process of the present system is as follows:
step A1: constructing a selection gradient magnetic field by constructing a plurality of groups of electromagnetic coil pairs in parallel, and forming an FFR region, a driving coil group and a receiving coil group;
step A2: the controller drives the imaging bed to send the object to be measured into the imaging cabin, the electromagnetic field intensity is controlled and changed, the position of the FFR area is changed, and the FFR area scans the target field of each group of magnet modules along a preset track;
step A3: the receiving coil group simultaneously records signals generated by the change of the induced voltage in each target field along with time;
step A4: filtering the signals through an electric control system, removing interference signals generated by a driving coil and noise signals generated by the coil, and amplifying the filtered signals;
step A5: transforming the obtained time domain signal into a frequency domain signal, and carrying out image reconstruction on the signal by using a deconvolution or regularization method;
step A6: and performing three-dimensional reconstruction on the signals in the FOV of each group of coils by a parallel computing method, and finally obtaining a final three-dimensional reconstruction result of the whole body size by an image splicing method.
It is clear to those skilled in the art that, for convenience and brevity of description, the specific working process and related description of the system described above may refer to the corresponding process in the foregoing method embodiment, and details are not described herein again.
It should be noted that the three-dimensional magnetic particle imaging system for the whole body provided in the above embodiment is only illustrated by the division of the above functional modules, and in practical applications, the above functions may be allocated to different functional modules according to needs, that is, the modules or steps in the embodiment of the present invention are further decomposed or combined, for example, the modules in the above embodiment may be combined into one module, or may be further split into a plurality of sub-modules, so as to complete all or part of the above described functions. The names of the modules and steps involved in the embodiments of the present invention are only for distinguishing the modules or steps, and are not to be construed as limiting the present invention
A fourth embodiment of the present invention provides an apparatus, including: at least one processor; and a memory communicatively coupled to at least one of the processors; wherein the memory stores instructions executable by the processor for execution by the processor to implement the above-described whole-body-oriented three-dimensional magnetic particle imaging method.
In a fourth embodiment of the present invention, a computer-readable storage medium is provided, wherein the computer-readable storage medium stores computer instructions for being executed by the computer to implement the above-mentioned whole-body-oriented three-dimensional magnetic particle imaging method.
It is clear to those skilled in the art that, for convenience and brevity of description, the specific working processes and related descriptions of the storage device and the processing device described above may refer to the corresponding processes in the foregoing method examples, and are not described herein again.
Referring now to FIG. 5, there is illustrated a block diagram of a computer system suitable for use as a server in implementing embodiments of the method, system, and apparatus of the present application. The server shown in fig. 5 is only an example, and should not bring any limitation to the functions and the scope of use of the embodiments of the present application.
As shown in fig. 5, the computer system includes a Central Processing Unit (CPU) 601, which can perform various appropriate actions and processes according to a program stored in a Read Only Memory (ROM) 602 or a program loaded from a storage section 608 into a Random Access Memory (RAM) 603. In the RAM603, various programs and data necessary for system operation are also stored. The CPU601, ROM 602, and RAM603 are connected to each other via a bus 604. An Input/Output (I/O) interface 605 is also connected to bus 604.
The following components are connected to the I/O interface 605: an input portion 606 including a keyboard, a mouse, and the like; an output section 607 including a Cathode Ray Tube (CRT), a Liquid Crystal Display (LCD), and the like, a speaker, and the like; a storage section 608 including a hard disk and the like; and a communication section 609 including a Network interface card such as a LAN (Local Area Network) card, a modem, or the like. The communication section 609 performs communication processing via a network such as the internet. The driver 610 is also connected to the I/O interface 605 as needed. A removable medium 611 such as a magnetic disk, an optical disk, a magneto-optical disk, a semiconductor memory, or the like is mounted on the drive 610 as necessary, so that a computer program read out therefrom is mounted in the storage section 608 as necessary.
In particular, according to an embodiment of the present disclosure, the processes described above with reference to the flowcharts may be implemented as computer software programs. For example, embodiments of the present disclosure include a computer program product comprising a computer program embodied on a computer readable medium, the computer program comprising program code for performing the method illustrated in the flow chart. In such an embodiment, the computer program may be downloaded and installed from a network through the communication section 609, and/or installed from the removable medium 611. More specific examples of a computer-readable storage medium may include, but are not limited to, an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), a compact disc read-only memory (CD-ROM), Optical storage devices, magnetic storage devices, or any suitable combination of the foregoing. In the present application, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: wireless, wire, fiber optic cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present application may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C + + or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The terms "first," "second," and the like are used for distinguishing between similar elements and not necessarily for describing or implying a particular order or sequence.
The terms "comprises," "comprising," or any other similar term are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of the present invention is obviously not limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can fall into the protection scope of the invention.
Claims (9)
1. A method of whole-body oriented three-dimensional magnetic particle imaging, the method comprising the steps of:
step S100, constructing an MPI imaging system according to the size of a measured object, wherein the MPI imaging system comprises a plurality of MPI imaging units and a controller which are coaxially arranged along the length direction of the measured object, and each MPI imaging unit is respectively in communication connection with the controller through a communication link;
step S200, after the object to be detected enters an imaging cabin of the MPI imaging system, the controller changes the position of the magnetic field-free area of each MPI imaging unit by respectively adjusting the electromagnetic magnetic field intensity of each MPI imaging unit, so that each magnetic field-free area respectively scans the target field of each MPI imaging unit along a preset track;
step S300, acquiring a first data signal generated by the change of the induced voltage in each target field along with time;
step S400, filtering each first data signal respectively, removing interference signals and noise signals generated by a driving coil in an MPI imaging unit, and amplifying the filtered data signals to obtain second data signals;
step S500, converting the second data signal from a time domain to a frequency domain, and respectively reconstructing a three-dimensional image based on a preset processing method to obtain a plurality of reconstructed image blocks;
and S600, splicing the reconstruction image blocks according to the relative position relation among the reconstruction image blocks to obtain a three-dimensional reconstruction result of the whole body size of the measured object.
2. The whole-body-oriented three-dimensional magnetic particle imaging method according to claim 1, wherein the MPI imaging unit comprises three sets of electromagnetic coil pairs and a receiving coil set, the electromagnetic coil pairs are coaxially arranged at intervals, the three sets of electromagnetic coil pairs are respectively distributed along three orthogonal directions, the axes of the three sets of electromagnetic coil pairs intersect at a point, the point is taken as an origin, the axes of the three sets of electromagnetic coil pairs are respectively an x axis, a y axis and a z axis, the receiving coil set is a pair of annular induction coils, and the pair of annular induction coils are respectively arranged on the outer sides of any set of electromagnetic coil pairs in parallel; the controller is in communication connection with the set of receive coils to acquire the current signals generated thereby.
3. The whole-body-facing three-dimensional magnetic particle imaging method according to claim 2, wherein the MPI imaging unit further comprises a cylindrical magnet disposed in the enclosed space of the three sets of electromagnetic coil pairs, the cylindrical magnet having a receiving space, the receiving spaces of the cylindrical magnets together constituting an imaging chamber of the MPI imaging system, the imaging chamber being used for receiving and carrying the object to be measured.
4. The whole-body-oriented three-dimensional magnetic particle imaging method according to claim 3, wherein the MPI imaging system further comprises an imaging bed and an imaging bed moving device, the imaging bed is used for carrying the object to be measured, and the controller drives the imaging bed to drive the object to be measured to enter an imaging cabin of the MPI imaging system by controlling the imaging bed moving device.
5. The whole-body-oriented three-dimensional magnetic particle imaging method according to claim 2, wherein the step S300 of obtaining the first data signal generated by the variation with time of the induced voltage in each target field is obtained by the receiving coil set.
6. The whole-body oriented three-dimensional magnetic particle imaging method according to any one of claims 1 to 5, wherein the predetermined processing method is a deconvolution or regularization method.
7. The three-dimensional magnetic particle imaging system for the whole body is characterized by comprising a plurality of coaxially arranged MPI imaging units, an imaging bed and an electric control unit, wherein the electric control unit is respectively in communication connection with the MPI imaging units through communication links;
the MPI imaging unit comprises two pairs of electromagnetic coils, a cylindrical magnet, a driving coil group and a receiving coil group; two electromagnetic coils in the electromagnetic coil pair are coaxial, and the axes of the two electromagnetic coil pairs are orthogonal; the cylindrical magnet is arranged in the surrounding space of the two pairs of electromagnetic coils, the axis of the cylindrical magnet passes through the axis orthogonal point of the two pairs of electromagnetic coils and is perpendicular to the plane formed by the axes of the two pairs of electromagnetic coils, and the cylindrical magnet of each MPI imaging unit is coaxially arranged; the driving coil group comprises two driving coils which are coaxially arranged at intervals, and the axis of the driving coil group is orthogonal to the axes of the two pairs of electromagnetic coils; the receiving coil group is a pair of annular induction coils which are respectively arranged on the outer sides of any group of electromagnetic coil pairs in parallel;
the electric control unit is configured to control the two pairs of electromagnetic coils of each MPI imaging unit to construct a gradient magnetic field and form a magnetic field-free area; when the imaging bed enters a set position in the cylindrical magnet, the electric control unit changes the electromagnetic field intensity of the MPI imaging unit according to a set control instruction to change the position of a magnetic field-free area, so that the MPI imaging unit respectively scans the target field of each MPI imaging unit along a preset track, acquires a first data signal generated by the change of induced voltage in each target field along time, respectively filters each first data signal, removes interference signals and noise signals generated by a driving coil in the MPI imaging unit, amplifies the filtered data signal to obtain a second data signal, converts the second data signal from a time domain to a frequency domain, respectively reconstructs three-dimensional images based on a preset processing method to obtain a plurality of reconstructed image blocks, and splices the reconstructed image blocks according to the relative position relationship among the reconstructed image blocks, and acquiring a three-dimensional reconstruction result of the whole body size of the measured object.
8. An electronic device, comprising:
at least one processor; and
a memory communicatively coupled to at least one of the processors; wherein,
the memory stores instructions executable by the processor for execution by the processor to implement the whole-body facing three-dimensional magnetic particle imaging method of any one of claims 1-6.
9. A computer-readable storage medium storing computer instructions for execution by the computer to implement the whole-body oriented three-dimensional magnetic particle imaging method of any one of claims 1-6.
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