CN115836989A - Whitening toothpaste composition and preparation method of toothpaste thereof - Google Patents
Whitening toothpaste composition and preparation method of toothpaste thereof Download PDFInfo
- Publication number
- CN115836989A CN115836989A CN202211666208.8A CN202211666208A CN115836989A CN 115836989 A CN115836989 A CN 115836989A CN 202211666208 A CN202211666208 A CN 202211666208A CN 115836989 A CN115836989 A CN 115836989A
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- percent
- toothpaste
- whitening
- sodium
- pyrophosphate
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Abstract
The invention relates to the technical field of whitening oral care products and preparation methods thereof, in particular to a whitening toothpaste composition and a preparation method of toothpaste thereof. The whitening toothpaste composition consists of sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate. The whitening anti-allergy toothpaste comprises the following raw materials: 20 to 70 percent of humectant, 12 to 25 percent of abradant, 1 to 15 percent of thickening agent, 0.2 to 2.0 percent of adhesive, 0.5 to 5 percent of surfactant, 0.3 to 0.5 percent of strontium chloride, 0.3 to 4 percent of potassium nitrate, 0.1 to 2 percent of abrasive particles, 0.05 to 0.5 percent of sweetening agent, 0.5 to 2 percent of essence and 0.7 to 7.5 percent of whitening toothpaste composition. When the toothpaste of the whitening and anti-allergy toothpaste is frequently used for brushing teeth, the dentin sensitivity can be effectively reduced and relieved, exogenous color stains can be prevented, the surface glossiness of teeth can be improved, the formation of color stains can be reduced, the natural color of the teeth can be restored, and the toothpaste is ideal in stability and has an ideal application prospect.
Description
Technical Field
The invention relates to the technical field of whitening oral care products and preparation methods thereof, in particular to a whitening toothpaste composition and a preparation method of toothpaste thereof.
Background
With the improvement of economic and living standards, consumers pay more and more attention to their own physical health, the oral health is closely related to the physical health and life quality of people, and a white and clean tooth can increase the social confidence among people. How to safely, mildly and effectively prevent and remove stains from teeth has become one of the oral problems of high concern to most consumers.
The tooth staining is classified into endogenous staining and exogenous staining, wherein the endogenous tooth staining is caused by abnormal tooth development or pulp cavity infection and commonly comprises pulp necrosis, dental fluorosis, tetracycline pigmentation and the like. Extrinsic staining of teeth is the change in tooth color caused by long-term ingestion of dark foods, beverages, tobacco, etc., or occupational exposure to certain minerals such as iron, sulfur, copper, etc. According to the Nielsen data, the market share of the whitening toothpaste is stable in the first two of the efficacy toothpaste market, and is popular with the consumers, but the actual whitening effect is also a doubtful worry in the mind of the consumers.
The whitening effect of toothpaste is mainly divided into physical whitening, i.e. the mechanical friction effect of an abrasive in toothpaste, and chemical whitening, i.e. the whitening of teeth by means of mechanisms such as chelation, biological decomposition, redox reaction and the like, of a surfactant, a calcium chelating agent, an enzyme, a polymer, an oxidant and the like in toothpaste. The single abrasive has limited physical whitening effect, and too high friction force easily causes tooth abrasion, thereby causing other problems such as tooth allergy and the like. It is difficult to achieve a good whitening effect by only surfactants and calcium chelating agents, the formulation requirements are high by adding biological enzymes to toothpaste, and some anionic surfactants can reduce or kill the enzyme activity. The oxidant is one of the common tooth whitening modes of professional medical institutions, for example, hydrogen peroxide has a good tooth whitening effect but strong irritation and may cause tooth sensitivity, and when the hydrogen peroxide is added into toothpaste, the stability problems of paste instability, gas expansion, water diversion and the like are easily caused. Therefore, the stable, mild and effective whitening toothpaste composition is researched, the tooth sensitivity is effectively prevented, the chemical whitening effect of the toothpaste is very necessary to be improved, the consumer can really and intuitively feel the obvious change of the tooth chromaticity, and the confidence of the whitening effect of the whitening toothpaste is established again.
Disclosure of Invention
The invention aims to provide a whitening toothpaste composition to solve the technical problems that the whitening toothpaste in the prior art has unsatisfactory whitening effect and stability and is easy to cause tooth sensitivity or tooth abrasion.
In order to achieve the purpose, the invention adopts the following technical scheme:
a whitening toothpaste composition comprises sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate.
The invention also provides whitening anti-allergy toothpaste containing the whitening toothpaste composition, which comprises the following raw materials in percentage by weight: 20 to 70 percent of humectant, 12 to 25 percent of abradant, 1 to 15 percent of thickening agent, 0.2 to 2.0 percent of adhesive, 0.5 to 5 percent of surfactant, 0.3 to 0.5 percent of strontium chloride, 0.3 to 4 percent of potassium nitrate, 0.1 to 2 percent of abrasive particles, 0.05 to 0.5 percent of sweetening agent, 0.5 to 2 percent of essence, 0.7 to 7.5 percent of whitening toothpaste composition and the balance of water.
The invention also provides a preparation method of the whitening anti-allergy toothpaste, which comprises the following steps:
s1: mixing a humectant and a liquid surfactant to obtain a mixture A; under the condition of stirring, sequentially adding a water solution of a sweetening agent, a mixed water solution of sodium phytate and sodium pyrophosphate, disodium dihydrogen pyrophosphate, potassium nitrate and strontium chloride into the mixture A, and uniformly mixing to obtain a mixed mixture B;
s2: mixing an abrasive, a thickening agent, abrasive particles, a solid surfactant and a binder to obtain a mixture C; uniformly mixing the mixture C and the mixture B to obtain a mixture D;
s3: and adding the essence into the mixture D, uniformly mixing, preparing the paste, degassing and filling to obtain the whitening and anti-allergy toothpaste.
The principle and the advantages of the scheme are as follows:
according to the technical scheme, the sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate are combined for the first time and are applied to the preparation of the toothpaste, and the combined use of the sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate shows a synergistic effect on oral whitening, so that an unexpected technical effect is obtained. In the toothpaste, sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate are all anti-stain/stain-removing agents, and compared with the single use of sodium phytate, disodium dihydrogen pyrophosphate or sodium pyrophosphate, the three anti-stain/stain-removing agents are compounded for use, the dissolving capacity of the toothpaste on exogenous stains of teeth can be enhanced better through the exertion of the synergistic promotion effect, and the use amount of a single active ingredient and the influence on the formula stability can be reduced. The sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate with specific contents and proportions are added into the toothpaste, and under the combined action of the sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate, the whitening effect of the toothpaste is better. Strontium chloride and potassium nitrate are anti-allergic active ingredients, and the addition amount of the strontium chloride and the potassium nitrate is not less than the clinical dosage, so that the anti-allergic effect is better. However, the compatibility of whitening components such as strontium chloride, sodium phytate and the like is poor, so that the respective activity of the strontium chloride or the sodium phytate is reduced, and the addition process of the two active components is explored to exert the effects of the strontium chloride and the sodium phytate to the maximum extent.
Wherein the sodium phytate is prepared from phytic acid, and is mainly derived from plants. The main functional group of the sodium phytate is a six-membered ring structure, contains 6 non-coplanar phosphate ester bonds, has strong chelating force, and organic anions (phosphate groups) contained in the sodium phytate can react with colored stains such as tea stains, coffee stains and the like deposited on the tooth surface or in an acquired membrane to generate organic composite salt capable of being dissolved in water, so that the stain removing effect is achieved; the phosphate group of the sodium phytate can generate chelation with hydroxyapatite which is the main component of the enamel, has stronger adsorbability, and can form a smooth and ion-selective permeation protective film on the surface of the enamel, on one hand, the deposition of the hydroxyapatite on the surface of the tooth can be increased through the adsorbability, on the other hand, the desorption of protein and pigment on the surface of the enamel can be promoted, and the formation of coffee stain, tea stain and the like on the surface of the tooth is reduced.
Disodium dihydrogen pyrophosphate is widely used in the food industry, and is commonly used as a buffering agent, a chelating agent, a stabilizer, an emulsifier, a color improver and the like, but is less used in oral care products. Disodium dihydrogen pyrophosphate can effectively dissolve alkaline dental calculus and chelate Fe 2+ 、Ca 2+ 、Mg 2+ The plasma converts the ions in the dental calculus into stable soluble complex, thereby inhibiting the formation of calcium phosphate deposit, removing the dental calculus and exogenous pigment penetrating into the dental calculus, and whitening teeth.
Sodium pyrophosphate, an effective anticalculus agent, is readily soluble in water, and alkaline in solution, and contains crystalline calcium hydroxy phosphate as main ingredient, and polyphosphate anion capable of chelating Ca in pyrophosphate 2+ 、Mg 2+ The plasma generates soluble complex, and the dental calculus can be removed by brushing teeth to achieve the effect of whitening teeth.
The strontium chloride anti-sensitive toothpaste has long use history, has obvious treatment effect on dentin hypersensitivity caused by exposure of tooth roots due to wedge-shaped defects and gingival recession, and can effectively block and seal small dentin orifices. The action mechanism of potassium nitrate is that potassium ions are released by tooth brushing and act on nerve endings of dentinal tubules, so that the excitability of nerve fibers is reduced, and the dentinal tubules can be blocked. The desensitization mechanism is that the potassium ion concentration around the dental pulp sensory nerve receptor is increased, the depolarization phenomenon is generated to reduce the nerve excitability, insoluble substances are generated to block dentinal tubules, and the dentin sensitivity symptom is relieved. The strontium chloride and the potassium nitrate are simultaneously added into the toothpaste, and the dentin sensitivity can be effectively relieved under the condition that the clinical dosage is not less than that, the technology is a double anti-sensitivity patent technology ZL03134926.9 of Dengkang oral care products GmbH.
In the preparation method of the whitening toothpaste, the sweetening agent, the strontium chloride, the potassium nitrate, the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate are respectively dissolved by water, and the aqueous solutions are completely mixed. Sodium phytate is very hygroscopic and is easy to absorb water and agglomerate when exposed to air, so that the sodium phytate is dissolved preferentially. Sodium pyrophosphate is dissolved by heating and boiling, and can be decomposed into disodium hydrogen phosphate, so that the complexing ability of the disodium hydrogen phosphate is reduced, and the disodium hydrogen phosphate is prevented from being dissolved by heating to boiling. The raw materials that this technical scheme used can not add simultaneously when mixing, and need add while stirring to according to certain order of adding, otherwise can seriously influence the lotion stability. The abrasive, abrasive particles, thickener, solid surfactant, and binder are thoroughly mixed to obtain mixture C. And mixing the mixture B and the mixture C, adding essence after uniformly stirring, continuously and uniformly stirring, then adding the mixture into a paste making machine for uniformly stirring and degassing for 40min under high vacuum to obtain the whitening toothpaste.
Further, the mass ratio of the sodium phytate to the disodium dihydrogen pyrophosphate is 1:3 to 4:1, the mass ratio of sodium pyrophosphate to disodium dihydrogen pyrophosphate is 1:3 to 2:1.
the inventor researches and discovers that sodium phytate generates thickening effect in the paste, and when the ratio of sodium phytate to disodium dihydrogen pyrophosphate is more than 4. The inventor also researches and finds that when the adding ratio of the disodium dihydrogen pyrophosphate to the sodium phytate is more than 3, the pH value of the paste is low, the paste is separated from water and oil, the tooth demineralization is easy to cause, the influence on the taste of the product is large, and the sour and astringent feeling is obvious when the product is used. Research shows that when sodium pyrophosphate with a certain proportion is added into the formula, the problems of the paste such as viscosity, pH value, water and oil separation, surface fineness, taste and the like are obviously improved. Mixing sodium pyrophosphate and disodium dihydrogen pyrophosphate in a mass ratio of 1:3 to 2:1, the paste has good stability and better whitening effect.
Further, the whitening toothpaste composition accounts for 0.7 to 7.5 percent of the toothpaste by mass.
Further, the whitening anti-allergy toothpaste comprises the following raw materials in percentage by weight: 22 to 60 percent of humectant, 12 to 25 percent of abradant, 1 to 12 percent of thickener, 0.5 to 1.5 percent of adhesive, 0.6 to 4.2 percent of surfactant, 0.1 to 2 percent of abrasive particles, 0.3 percent of strontium chloride, 4 percent of potassium nitrate, 0.05 to 0.35 percent of sweetener, 0.7 to 1.6 percent of essence, 0.3 to 2.5 percent of disodium dihydrogen pyrophosphate, 0.1 to 3 percent of sodium phytate, 0.3 to 2 percent of sodium pyrophosphate and the balance of water.
Toothpaste also contains other ingredients: humectant, thickener, binder, surfactant, anti-allergy active ingredient, sweetener and essence. The components selected by the invention are all raw materials which can be used in the oral cavity, and the dosage of the components can be selected according to the actual requirements such as the taste and the effect of the required toothpaste.
Further, the humectant includes at least one of sorbitol, glycerin, polyethylene glycol, and propylene glycol; the surfactant comprises at least one of sodium dodecyl sulfate, amino acid type surfactant and betaine type surfactant.
The humectant has the functions of keeping moisture of the paste, preventing freezing and maintaining the fluidity of the paste; the surfactant has the functions of emulsifying, foaming and enhancing the cleaning effect.
Further, the thickener is thickening silica; the abrasive is high-cleaning silicon dioxide; the friction particles are silicon dioxide friction particles; more than or equal to 70 percent of the silicon dioxide friction particles have the particle size distribution of 80-140 meshes.
The abrasive agent can remove tooth stain by mechanical friction, has high cleaning power, and does not damage enamel. The selected high-cleaning type silicon dioxide (abrasive) has high cleaning force and low abrasion to enamel. The thickening agent has a shaping effect.
The silicon dioxide friction particles are used as a polishing agent, the silicon dioxide friction particles are granular, and the gel polymerization method is adopted for preparation, so that the gel polymerization type silicon dioxide friction particles can bring mild friction feeling in the using process, can be rapidly and uniformly dispersed in the product, and cannot be aggregated. The particle size of the silicon dioxide friction particles is 80-140 meshes, so that a more ideal cleaning effect can be achieved. After the silica abrasive particles are added into the toothpaste, the substances have synergistic effect with sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate, the whitening effect of the toothpaste can be obviously enhanced, and the prepared toothpaste can effectively remove exogenous color stains on teeth, such as tea stains, coffee stains and the like. Improve the smoothness of the tooth surface and reduce the re-formation of pigment and stain on the tooth surface.
Further, the binder comprises at least one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, xanthan gum, hydroxypropyl guar and carbomer; the sweetener comprises at least one of saccharin sodium, sucralose, stevioside, xylitol, and acesulfame potassium.
The sweetener can improve the taste of toothpaste. The adhesive has the functions of endowing paste with stable three-dimensional space structure and enabling the prepared toothpaste to have better thixotropy and stability
Further, the thickness of the whitening anti-allergy toothpaste is 9-15 mm.
The inventor researches and explores that the thickness of the paste is controlled to be 9-15 mm by optimizing the viscosity of the paste, the phenomena of surface thickening, moisture and oil separation and shelling of the paste can be avoided, and the paste has good taste.
Compared with the prior art, the invention has the beneficial effects that:
(1) The toothpaste takes sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate as stain removers, and under the combined action of the sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate, compared with a single whitening agent, the toothpaste has better whitening effect.
(2) The toothpaste further comprises a plurality of effective components such as sodium phytate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, an abrasive, abrasive particles, potassium nitrate, strontium chloride and the like and orally acceptable raw materials, the chelating dissolution, the friction cleaning, the polishing whitening and the dentin sensitivity prevention and relief are tightly combined together, the effects of the effective components in the toothpaste are exerted to the maximum extent through a synergistic effect, and the problems of the compatibility of the active components and the conglomeration, roughness, water and oil separation, shelling, low pH value, poor taste and the like of the toothpaste caused by the compatibility of the active components are solved, so that the aims of cleaning, removing stains, improving the tooth surface smoothness, reducing the re-formation of pigments and stains on the tooth surface and effectively enhancing the whitening effect of the toothpaste are achieved.
(3) The preparation method of the toothpaste has simple process, and the provided toothpaste has smooth, fine, uniform and stable paste, is easy to disperse when in use, has comfortable mouthfeel, and is suitable for daily use.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the technical means used in the following examples and experimental examples are conventional means well known to those skilled in the art, and the materials, reagents and the like used therein are commercially available.
The whitening functional components used in the whitening toothpaste in the scheme are composed of sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate. The mass ratio of the sodium phytate to the disodium dihydrogen pyrophosphate is 1:3 to 4:1 (more preferably 5: 3 to 2:1 (more preferably 3. The mass sum of the sodium phytate, the disodium dihydrogen pyrophosphate and the sodium pyrophosphate accounts for 0.7-7.5% (more preferably 1.1-6.3%) of the toothpaste.
Besides the whitening efficacy components, the formula of the whitening toothpaste also comprises: 20 to 70 percent of humectant, 1 to 15 percent of thickener, 0.2 to 2.0 percent of adhesive, 0.5 to 5 percent of surfactant, 0.3 to 0.5 percent of strontium chloride, 0.3 to 4 percent of potassium nitrate, 0.05 to 0.5 percent of sweetener and 0.5 to 2 percent of essence.
Preferably, the formula of the whitening toothpaste in the scheme is as follows: a humectant 22 to 60% (more preferably 24 to 53%), an abrasive 12 to 25% (more preferably 12 to 22%), a thickener 1 to 12% (more preferably 1.5 to 10%), a surfactant 0.6 to 4.2% (more preferably 1.5 to 4.0%), a sweetener 0.05 to 0.4% (more preferably 0.12 to 0.4%), a perfume 0.7 to 1.6% (more preferably 0.8 to 1.5%), disodium dihydrogen pyrophosphate 0.3 to 2.5% (more preferably 0.5 to 2.0%), sodium phytate 0.1 to 3% (more preferably 0.3 to 2.5%), a particle 0.1 to 2% (more preferably 0.1 to 1.8%), a binder 0.5 to 1.5% (more preferably 0.6 to 1.4%), strontium chloride 0.3%, potassium nitrate 4%, and the balance water.
Wherein, the humectant comprises at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol;
the thickener is thickening silicon dioxide (Jinsanjiang silicon material Co., ltd., H type, has the characteristic of high water absorption capacity and can play a thickening role);
the abrasive is high-cleaning silicon dioxide (Jinsanjiang silicon material Co., ltd., MIC type, has the characteristic of large friction value and has ideal cleaning effect);
the adhesive comprises at least one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, xanthan gum, hydroxypropyl guar gum and carbomer;
the surfactant comprises at least one of sodium dodecyl sulfate, sodium dodecyl sulfonate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate and cocamidopropyl betaine;
the sweetener comprises at least one of saccharin sodium, sucralose, stevioside, xylitol, and acesulfame potassium.
The friction particles are silicon dioxide friction particles which are used as a polishing agent, the silicon dioxide friction particles are granular, and the gel polymerization method is adopted for preparation, so that the gel polymerization type silicon dioxide friction particles can bring mild friction feeling in the using process, and can be rapidly and uniformly dispersed in the product without aggregation. The specification of the silicon dioxide friction particles used in the scheme is as follows: more than or equal to 70 percent of the silicon dioxide friction particles have a particle size distribution of 80-140 meshes (the particle size distribution of less than 30 percent of the silicon dioxide friction particles is more than 140 meshes; the particle size distribution of less than 5 percent of the silicon dioxide friction particles is less than 80 meshes), and the silicon dioxide friction particles with a main particle size distribution of 80-140 meshes are used in the subsequent examples. The silicon dioxide abrasive particles were purchased from jin san jiang (Zhaoqing) silicon materials, inc., model number: white W3 type, the technical characteristics of the product are as follows: the total salt is less than or equal to 1.0 percent, the pH value is 5.5-8.5, and the volatile matter at 105 ℃ is less than or equal to 10 percent. The gel polymerization method is a method of preparing organic or inorganic salt into a solution, then adding a solution capable of nucleating and gelling the solution, controlling the gelling process to obtain gel with spherical particles, and calcining and decomposing the gel at a certain temperature to obtain a required phase. The silica abrasive particles of the present invention were prepared by the above-mentioned method and commercially available.
The essence is an aromatizing agent and has the functions of endowing the toothpaste with pleasant aroma, cool mouthfeel and fresh breath. Can be selected from essence such as herba Menthae, herba Menthae Rotundifoliae, flower fragrance, fruit fragrance, tea fragrance, medicinal fragrance, etc., and composition or toothpaste with skin whitening and anti-allergy effects.
Example 1
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
53% of sorbitol, 22% of high-cleanness silicon dioxide, 2.5% of thickening silicon dioxide, 2% of sodium dodecyl sulfate, 0.28% of saccharin sodium, 1% of essence, 0.5% of disodium dihydrogen pyrophosphate, 0.3% of sodium phytate, 0.5% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 0.1% of abrasive particles, 0.7% of sodium carboxymethylcellulose and the balance of deionized water.
The preparation method of the toothpaste in the embodiment comprises the following steps:
(1) Mixing humectant and liquid surfactant, adding sweetener solution (dissolving with appropriate amount of water), pre-mixing uniform mixed solution of sodium phytate and sodium pyrophosphate (dissolving with appropriate amount of water), adding disodium dihydrogen pyrophosphate solution (dissolving with appropriate amount of water), and adding potassium nitrate and strontium chloride solution (dissolving with appropriate amount of water). The amount of solvent water used for each solution is not a constant value, as long as the water is capable of sufficiently dissolving the material without exceeding the total amount of water in the formulation that is available to dissolve the soluble material. The above-mentioned operation processes are all under the condition of stirring, slowly adding, after adding, continuously stirring until uniformly mixing.
(2) Mixing high-cleaning silicon dioxide, a thickening agent, abrasive particles, a solid surfactant and a binding agent, and then adding the mixture into the liquid obtained in the step (1) to stir uniformly.
(3) And (3) adding essence into the paste body obtained in the step (2), uniformly stirring, transferring to paste making equipment, performing conventional vacuum degassing in the prior art for 40min, and filling to obtain the whitening and anti-allergy toothpaste.
The toothpaste prepared in this example had a consistency of 15mm.
Example 2
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
48% of sorbitol, 5% of polyethylene glycol, 18% of high-cleanness silicon dioxide, 3% of thickening silicon dioxide, 1.5% of sodium dodecyl sulfate, 0.5% of sodium lauroyl sarcosinate, 0.28% of saccharin sodium, 1% of essence, 0.5% of disodium dihydrogen pyrophosphate, 1% of sodium phytate, 0.5% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 0.3% of abrasive particles, 0.6% of sodium carboxymethylcellulose, 0.2% of carrageenan and the balance of deionized water;
the preparation method of the toothpaste described in this example is the same as that of example 1, and the thickness of the toothpaste in this example is 12mm.
Example 3
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
40% of sorbitol, 5% of glycerol, 17% of high-cleaning type silicon dioxide, 4% of thickening type silicon dioxide and 2.3% of sodium lauroyl sarcosinate; 0.14% of saccharin sodium, 0.04% of sucralose, 1.1% of essence, 0.8% of disodium dihydrogen pyrophosphate, 0.5% of sodium phytate, 1% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 0.5% of abrasive particles, 1.0% of hydroxypropyl guar gum, 0.3% of carrageenan and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The toothpaste of this example had a consistency of 12mm.
Example 4
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
35% of sorbitol, 3% of propylene glycol, 15% of high-cleanness silicon dioxide, 1.5% of thickening silicon dioxide, 2.0% of sodium dodecyl sulfate, 0.25% of saccharin sodium, 1.2% of essence, 0.8% of disodium dihydrogen pyrophosphate, 1% of sodium phytate, 0.3% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 0.7% of abrasive particles, 1.0% of sodium carboxymethylcellulose, 0.4% of carbomer and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The toothpaste of this example had a consistency of 9mm.
Example 5
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
28% of sorbitol, 5% of polyethylene glycol, 8% of glycerol, 14.5% of high-cleanness silicon dioxide, 4% of thickening silicon dioxide, 3% of sodium dodecyl sulfate, 0.35% of acesulfame, 0.9% of essence, 1.1% of disodium dihydrogen pyrophosphate, 0.8% of sodium phytate, 0.8% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 0.7% of abrasive particles, 1.4% of carboxyethyl cellulose and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The consistency of the toothpaste of this example was 12mm.
Example 6
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
20% of sorbitol, 4% of polyethylene glycol, 14% of high-cleaning silicon dioxide, 3% of thickening silicon dioxide, 2.5% of cocamidopropyl betaine, 0.1% of sucralose, 0.05% of stevioside, 0.8% of essence, 1.2% of disodium dihydrogen pyrophosphate, 0.5% of sodium phytate, 1% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 1.2% of abrasive particles, 0.5% of xanthan gum, 0.5% of sodium alginate and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The toothpaste of this example had a consistency of 9mm.
Example 7
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
21% of glycerin, 6% of propylene glycol, 13% of high-cleaning silicon dioxide, 7% of thickening silicon dioxide, 4.0% of sodium cocoyl methyl taurate, 0.4% of acesulfame potassium, 1.5% of essence, 1.5% of disodium dihydrogen pyrophosphate, 1.5% of sodium phytate, 1.5% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 1.5% of abrasive particles, 0.6% of xanthan gum, 0.4% of carrageenan and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The consistency of the toothpaste of this example was 15mm.
Example 8
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
30% of sorbitol, 12% of high-cleanness silicon dioxide, 10% of thickening silicon dioxide, 1.5% of cocamidopropyl betaine, 0.12% of sucralose, 1.3% of essence, 1% of disodium dihydrogen pyrophosphate, 1.5% of sodium phytate, 1% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 1.5% of abrasive particles, 0.2% of xanthan gum, 0.55% of carrageenan and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The toothpaste of this example had a consistency of 12mm.
Example 9
In an embodiment of the whitening toothpaste of the present invention, the toothpaste comprises the following components by mass:
35% of glycerin, 13.5% of high-cleaning silicon dioxide, 9% of thickening silicon dioxide, 2.0% of sodium cocoyl methyl taurate, 2.0% of sodium lauroyl sarcosinate, 0.2% of stevioside, 1% of essence, 2% of disodium dihydrogen pyrophosphate, 2.5% of sodium phytate, 1.8% of sodium pyrophosphate, 0.3% of strontium chloride, 4% of potassium nitrate, 1.8% of abrasive particles, 0.6% of sodium carboxymethylcellulose and the balance of deionized water.
The preparation method of the toothpaste described in this example is the same as that of example 1. The consistency of the toothpaste of this example was 15mm.
Table 1: toothpaste formulations of examples 1-9
Experimental example 1: evaluation of stain-proofing and stain-removing whitening efficacy
A whitening anti-sensitivity toothpaste was formulated according to the components shown in table 2 and the method of example 1.
Table 2: toothpaste formula
Hydroxyapatite (HA) powder was used as a substrate to simulate human teeth, and black tea was used as an exogenous pigment to stain HA. According to the experiment, the black tea is used for dyeing the hydroxyapatite powder which is treated by the supernatant of the toothpaste slurry in advance, and the effect of preventing the exogenous tooth stain of the toothpaste is evaluated by comparing the dyeing depth; the hydroxyapatite powder dyed by black tea is treated by using the supernatant of the toothpaste slurry, and the effect of the toothpaste on removing the exogenous dental stain is evaluated by comparing the fading depth of the color. The experimental results were evaluated qualitatively and quantitatively using visual comparison and UV qualitative analysis.
(1) And (3) stain prevention experiment:
0.40g of hydroxyapatite powder is weighed into 4 centrifuge tubes, the numbers of the centrifuge tubes are 1, 2, H and L respectively, 1 tube is an experimental group (experimental group 1, 3-15), 2 tubes is a control group (experimental group 2), H tube is a positive control of smokeless tea stain treatment, and L tube is a negative control of non-toothpaste liquid treatment (the same below).
Adding 10mL experimental group toothpaste liquid (experimental group 1, 3-15) and control group toothpaste liquid (experimental group 2) into 1 and 2 tubes respectively, adding 10mL water into H and L tubes, stirring with six-joint stirrer for 3min,7500r/min, centrifuging for 10min, and discarding supernatant. Respectively adding 20mL of water, stirring for 2min,7500r/min, centrifuging for 10min, discarding supernatant, and repeating the steps for 2 times. The preparation method of the toothpaste liquid comprises the following steps: 5g of toothpaste is dispersed in 15mL of deionized water, fully mixed and then centrifuged (7500 r/min for 10 min) to obtain a toothpaste slurry supernatant.
Adding 10mL of water into H tube, adding 10mL of black tea leachate into other tubes, stirring with six-joint stirrer for 2min,7500r/min, centrifuging for 10min, and discarding supernatant. Respectively adding 20mL of water, stirring with a six-joint stirrer for 2min,7500r/min, centrifuging for 10min, and discarding the supernatant. 20mL of water was added, the six-up stirrer was stirred for 2min, then filtered, and the precipitate on the filter paper was washed 1 time with 10mL of water. The mixture was left in air overnight and air-dried. The preparation method of the black tea leachate comprises the following steps: soaking 8g black tea in 100 deg.C deionized water dispersed in 100mL for 30min, and filtering to obtain tea water to obtain black tea leachate. To ensure the parallelism of the experiments, the same black tea was used for all experiments.
(2) Stain removal experiment
0.40g of hydroxyapatite powder was weighed into 4 centrifuge tubes numbered 1, 2, H, L, respectively.
Adding 10mL of water into tube H, adding 10mL of black tea leachate into other tubes, stirring with six-joint stirrer for 3min,7500r/min, centrifuging for 10min, and discarding supernatant. Adding 20mL of water, stirring with a six-connection stirrer for 2min,7500r/min, centrifuging for 10min, discarding the supernatant, and repeating the step for 2 times.
Adding 10mL experimental group toothpaste solution and control group toothpaste solution into 1 and 2 tubes, adding 10mL water into H and L tubes, stirring with six-joint stirrer for 2min,7500r/min, centrifuging for 10min, and discarding supernatant. Then respectively adding 20mL of water, stirring for 2min by a six-connection stirrer, 7500r/min, centrifuging for 10min, and removing supernatant. Then 20mL of water was added, and the mixture was stirred for 2min with a six-joint stirrer, followed by filtration, and the precipitate on the filter paper was washed 1 time with 10mL of water. The mixture was left in air overnight and air-dried.
(3) Colorimetric observation
The color of the treated hydroxyapatite powder is observed by naked eyes, and the darker the color is, the poorer the whitening effect is; conversely, the lighter the color, the better the whitening effect.
(4) UV analysis
0.1g of the treated powder (i.e., the powder adhered to the filter paper) was weighed, 10mL of 1mol/L hydrochloric acid was added, and the mixture was stirred for 3 minutes in a six-up stirrer to be dissolved. 7500r/min, centrifuging for 10min. The supernatant was taken and the absorbance of all solutions at a wavelength of 350nm was measured with 1mol/L hydrochloric acid as a reference. The data was processed according to the following formula:
E＝(A1-As)/(A1-Ah)×100
a1: absorbance of the L-tube; ah: absorbance of H-tube; as: absorbance of 1 tube or 2 tubes.
Description of the drawings: the higher the E value, the better the stain-preventing effect of the toothpaste. Since the effect of the stain on the results is very great and it is very difficult to obtain the same stain source, the stain control efficacy E values are used here for evaluation of the results of different experiments without direct comparison with absolute absorbance values. See table 3 for experimental results.
Table 3: evaluation results of stain-preventing and stain-removing whitening efficacy
From the experimental data, when the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate are used simultaneously, the whitening effect is most ideal. More specifically, comparing experimental group 1 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate + abrasive particles), experimental group 4 (sodium pyrophosphate + abrasive particles), experimental group 5 (sodium phytate + abrasive particles) and experimental group 6 (disodium dihydrogen pyrophosphate + abrasive particles) in table 3, it was found that: compared with the toothpaste which contains one of disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate as an anti-stain/cleaning agent, the toothpaste has obviously improved whitening effect when the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate are simultaneously contained in the toothpaste. Furthermore, the inventors should emphasize that although disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate can be used as stain-preventing/removing agents, theoretically, the combined effect is only the superposition of the three, and in the present embodiment, when the total amount of the three used in combination and the amount of the three used in each case are consistent, the whitening effect (stain-preventing test and stain-removing test E value) of the experimental group 1 is better than that of the experimental group 4, the experimental group 5 and the experimental group 6, which indicates that the combined use of disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate produces synergistic effect.
Comparing the experiment group 9 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate), the experiment group 10 (disodium dihydrogen pyrophosphate), the experiment group 14 (sodium phytate) and the experiment group 15 (sodium pyrophosphate) in table 3, it was found that the whitening effect of the toothpaste is remarkably improved when one of the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate is contained as the stain preventing/removing agent, compared with the toothpaste containing one of the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate alone, when the amount of the one of the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate is the same.
Comparing experiment group 9 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate), experiment group 11 (disodium dihydrogen pyrophosphate + sodium phytate), experiment group 12 (disodium dihydrogen pyrophosphate + sodium pyrophosphate), and experiment group 13 (sodium phytate + sodium pyrophosphate) in table 3, it was found that: any two whitening components of disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate are combined, and under the condition that the total dosage is consistent, the whitening effect is obviously lower than that of the whitening effect of the composition containing disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate. The same conclusions can be drawn by comparing the experimental group 1 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate + abrasive particles), the experimental group 7 (disodium dihydrogen pyrophosphate + sodium phytate + abrasive particles), and the experimental group 8 (disodium dihydrogen pyrophosphate + sodium pyrophosphate + abrasive particles) in table 3.
Comparing in table 3, experimental group 1 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate + abrasive particles) and experimental group 9 (disodium dihydrogen pyrophosphate + sodium phytate + sodium pyrophosphate), it was found that: the abrasive particles can enhance the whitening effect of disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate on the toothpaste, and in fact, when the toothpaste contains disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate, the whitening effect is better, and it is very difficult to enhance the whitening effect to the effect of the experimental group 1 after the abrasive particles are added, which is hard to be expected by those skilled in the art. The particle size distribution of the silica friction particles used in the experimental group 1 is 80-140 meshes (not less than 70%, more than 140 meshes, less than 30%, less than 80 meshes, less than 5%), and the silica friction particles can be well matched with disodium dihydrogen pyrophosphate, sodium phytate and sodium pyrophosphate to realize the whitening effect.
The inventors have also tried to change the particle size of the abrasive particles in order to find the most suitable abrasive particles. The inventors tried to use silica abrasive particles having a particle size distribution of 150 to 190 mesh (> 80%, > 190 mesh, < 20%, < 150 mesh, < 5%) prepared by a gel polymerization method, and other preparation conditions were the same as those of experiment group 1, and since the particle size was too small, the silica abrasive particles were very easily aggregated, so that the stability of the paste prepared was poor, and the phenomena of oil separation, shelling, coarsening, and granulation occurred in the accelerated experiments (90 days at 45 ℃). In addition, the anti-stain test and the stain removal test also show the disadvantage of using the silica friction particles with the particle size distribution of 150-190 meshes, and the E value is reduced by about 15 percent and even worse than the experimental group 9. This indicates that the use of silica abrasive particles having a particle size distribution of 150 to 190 mesh does not increase the cleaning effect, but also decreases the stability of the product due to agglomeration. The inventor tried to use silica abrasive particles with a particle size distribution of 40-70 mesh (not less than 60%; not less than 70 mesh; not more than 40%; not less than 40 mesh; not more than 5%) prepared by a gel polymerization method, and other preparation conditions were the same as those of experiment group 1, and the prepared paste had poor stability, exhibited phenomena such as moisture and oil separation, peeling, thickening, etc. in accelerated experiments (45 ℃ for 90 days), had strong gritty feel, and easily damaged teeth. However, the cleaning effect (E value) of the abrasive particles using silica having a particle size distribution of 40 to 70 mesh was not much different from that of the experimental group.
In addition to the use of silica abrasive particles, the inventors have tried to use ordinary high-cleaning silica instead of silica abrasive particles, and the other preparation conditions are the same as those in experimental group 1, and found that in this way, the E values shown in the stain prevention test and the stain removal test are similar to those in experimental group 9, and the whitening effect is not improved.
In table 3, the experiment group 5 and the experiment group 14 separately added sodium phytate, the whitening effect was general, and the paste had higher viscosity. The experiment groups 6 and 10 independently add the disodium dihydrogen pyrophosphate, so that the whitening effect is good, but the pH value of the paste is low, so that the stability of the paste is poor, the phenomena of water separation, oil separation, shelling and the like occur, and the taste is poor. In the experimental group 15, sodium pyrophosphate is added alone, so that the paste stability and the taste are normal, but the whitening effect is general. The experimental group 4 also had problems similar to the experimental group 15, but the situation was slightly better due to the addition of the friction particles. The addition of disodium dihydrogen pyrophosphate can solve the problem that the single use of the sodium phytate under the condition of higher concentration can increase the viscosity of the product. The use of disodium dihydrogen pyrophosphate alone at higher concentrations leads to more serious paste stability problems, but the addition of sodium phytate and sodium pyrophosphate in addition to disodium dihydrogen pyrophosphate can overcome the above problems. Therefore, the ideal whitening effect cannot be achieved by adding a certain whitening active ingredient alone or by simply combining two ingredients, and the problems of poor paste stability and poor mouthfeel can be caused. Meanwhile, the inventor also inspects the effects of the whitening anti-allergy toothpaste in the embodiments 1-9 according to the method of the experimental example, the toothpaste product does not have the phenomena of oil separation, shelling and the like, and has good taste, normal viscosity and pH value of 6-8; in the stain resistance test and the stain removal test, the color score is 1, the E of the stain resistance test is more than 50, and the E of the stain removal test is more than 90. In addition, the technical parameters of the whitening anti-allergy toothpaste can be maintained at the following levels, so that the effects can be achieved: the mass sum of the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate accounts for 0.7-7.5% of the toothpaste, and the mass ratio of the sodium phytate to the disodium dihydrogen pyrophosphate is 1:3 to 4:1, the mass ratio of sodium pyrophosphate to disodium dihydrogen pyrophosphate is 1:3 to 2:1; the percentage of the mass of the friction particles to the mass of the toothpaste is 0.1-2%; 20 to 70 percent of humectant, 12 to 25 percent of abrasive, 1 to 15 percent of thickening agent, 0.5 to 5 percent of surfactant, 0.05 to 0.5 percent of sweetening agent, 0.7 to 1.6 percent of essence, 0.5 to 1.5 percent of adhesive, 0.3 percent of strontium chloride, 4 percent of potassium nitrate and the balance of water. Researches show that the components of the whitening toothpaste have the effects when other values are taken within the range, and the details are not repeated herein.
In conclusion, when the 4 substances, namely the disodium dihydrogen pyrophosphate, the sodium phytate and the sodium pyrophosphate, act together, the prepared toothpaste can not only effectively resist the color stains and remarkably reduce the formation of pigments and stains on the tooth surfaces, but also effectively remove the exogenous color stains generated on the tooth surfaces, and the toothpaste has good stability and mouthfeel. Therefore, the whitening toothpaste has stable quality and obvious whitening effect and meets the public requirements.
Comparative example 1:
the comparative example used the toothpaste formulation of experimental group 1 of experimental example 1, but the preparation method was different and specifically as follows:
(1) Mixing humectant and liquid surfactant, adding water, sweetener, sodium phytate, sodium pyrophosphate, disodium dihydrogen pyrophosphate, potassium nitrate and strontium chloride, and stirring.
(2) Mixing high-cleaning silicon dioxide, a thickening agent, abrasive particles, a solid surfactant and a binding agent, and then adding the mixture into the liquid obtained in the step (1) to stir uniformly.
(3) And (3) adding essence into the paste body obtained in the step (2), uniformly stirring, transferring to paste making equipment, performing conventional vacuum degassing in the prior art for 40min, and filling to obtain the whitening and anti-allergy toothpaste.
After the step (2) of mixing, the mixture is normal, but the whitening anti-allergy toothpaste prepared by the method has the problem of unstable paste, and the phenomena of coarsening, granulation and the like appear after 90 days of high-temperature accelerated experiment at 45 ℃, and do not meet the related standards of toothpaste.
Comparative example 2
The comparative example used the toothpaste formulation of experimental group 1 of experimental example 1, but the preparation method was different and specifically as follows:
(1) Mixing humectant and liquid surfactant, adding sweetener solution (dissolved in appropriate amount of water), strontium chloride solution (dissolved in appropriate amount of water), sodium phytate solution (dissolved in appropriate amount of water), potassium nitrate (dissolved in appropriate amount of water), sodium pyrophosphate solution (dissolved in appropriate amount of water), and disodium dihydrogen pyrophosphate solution (dissolved in appropriate amount of water). The above-mentioned operation processes are all under the condition of stirring, slowly adding, after adding, continuously stirring until uniformly mixing.
(2) Mixing the high-cleanness silicon dioxide, the thickening agent, the friction particles, the solid surfactant and the adhesive, and then adding the mixture into the liquid obtained in the step 1 to be uniformly stirred.
(3) And (3) adding essence into the paste body obtained in the step (2), uniformly stirring, transferring to paste preparation equipment, performing conventional vacuum degassing for 40min in the prior art, and filling to obtain the whitening and anti-allergy toothpaste.
In the liquid-material mixing process, a small amount of insoluble substances can be seen after the strontium chloride and the sodium phytate are added, the whitening and anti-allergy toothpaste prepared in the manner has the problem of instable paste, and the phenomena of oil separation, shelling, coarse turning, granulation and the like appear after 90 days of high-temperature acceleration experiment at 45 ℃, and do not meet the related standards of the toothpaste.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. A whitening toothpaste composition is characterized by comprising sodium phytate, disodium dihydrogen pyrophosphate and sodium pyrophosphate.
2. The whitening toothpaste composition according to claim 1, wherein the mass ratio of the sodium phytate to the disodium dihydrogen pyrophosphate is 1:3 to 4:1, the mass ratio of sodium pyrophosphate to disodium dihydrogen pyrophosphate is 1:3 to 2:1.
3. the whitening toothpaste composition according to claim 2, wherein the whitening toothpaste composition is contained in the toothpaste in an amount of 0.3 to 7.5% by mass.
4. Whitening anti-sensitivity toothpaste containing a whitening toothpaste composition according to any one of claims 1 to 3, characterized in that the whitening anti-sensitivity toothpaste comprises the following raw materials in percentage by weight: 20 to 70 percent of humectant, 12 to 25 percent of abradant, 1 to 15 percent of thickening agent, 0.2 to 2.0 percent of adhesive, 0.5 to 5 percent of surfactant, 0.3 to 0.5 percent of strontium chloride, 0.3 to 4 percent of potassium nitrate, 0.1 to 2 percent of abrasive particles, 0.05 to 0.5 percent of sweetening agent, 0.5 to 2 percent of essence, 0.7 to 7.5 percent of whitening toothpaste composition and the balance of water.
5. The whitening and anti-allergy toothpaste according to claim 4, which is prepared from the following raw materials in percentage by weight: 22 to 60 percent of humectant, 12 to 25 percent of abradant, 1 to 12 percent of thickener, 0.5 to 1.5 percent of adhesive, 0.6 to 4.2 percent of surfactant, 0.1 to 2 percent of abrasive particles, 0.3 percent of strontium chloride, 4 percent of potassium nitrate, 0.05 to 0.35 percent of sweetener, 0.7 to 1.6 percent of essence, 0.3 to 2.5 percent of disodium dihydrogen pyrophosphate, 0.1 to 3 percent of sodium phytate, 0.3 to 2 percent of sodium pyrophosphate and the balance of water.
6. The whitening and anti-sensitivity toothpaste according to claim 5, wherein the humectant comprises at least one of sorbitol, glycerin, polyethylene glycol and propylene glycol; the surfactant comprises at least one of sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate and cocamidopropyl betaine.
7. The whitening and anti-sensitivity toothpaste according to claim 5, wherein the thickener is thickening silica; the abrasive is high-cleaning silicon dioxide; the friction particles are silicon dioxide friction particles; more than or equal to 70 percent of the silicon dioxide friction particles have the particle size distribution of 80-140 meshes.
8. The whitening anti-sensitivity toothpaste according to claim 5, wherein the binder comprises at least one of sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, xanthan gum, hydroxypropyl guar gum, and carbomer; the sweetener comprises at least one of saccharin sodium, sucralose, stevioside, xylitol, and acesulfame potassium.
9. The whitening and anti-sensitivity toothpaste according to claim 5, wherein the thickness is 9-15 mm.
10. The preparation method of the whitening and anti-allergy toothpaste according to any one of claims 5 to 9, characterized by comprising the following steps:
s1: mixing a humectant and a liquid surfactant to obtain a mixture A; under the condition of stirring, sequentially adding a water solution of a sweetening agent, a mixed water solution of sodium phytate and sodium pyrophosphate, a disodium dihydrogen pyrophosphate water solution, a potassium nitrate water solution and a strontium chloride water solution into the mixture A, and uniformly mixing to obtain a mixed mixture B;
s2: mixing an abrasive, a thickening agent, abrasive particles, a solid surfactant and a binder to obtain a mixture C; uniformly mixing the mixture C and the mixture B to obtain a mixture D;
s3: and adding the essence into the mixture D, uniformly mixing, preparing the paste, degassing and filling to obtain the whitening and anti-allergy toothpaste.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100000068A (en) * | 2008-06-24 | 2010-01-06 | 김승광 | Composition of whitening toothpast |
| CN106333866A (en) * | 2016-08-31 | 2017-01-18 | 重庆登康口腔护理用品股份有限公司 | High-salinity composition having functions of resisting dentine hypersensitivity and whitening, toothpaste and preparation method of toothpaste |
| CN107625659A (en) * | 2017-09-04 | 2018-01-26 | 美晨集团股份有限公司 | A kind of whitening toothpaste and preparation method thereof |
| CN110840813A (en) * | 2019-12-09 | 2020-02-28 | 上海绿瑞生物科技有限公司 | Whitening composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100000068A (en) * | 2008-06-24 | 2010-01-06 | 김승광 | Composition of whitening toothpast |
| CN106333866A (en) * | 2016-08-31 | 2017-01-18 | 重庆登康口腔护理用品股份有限公司 | High-salinity composition having functions of resisting dentine hypersensitivity and whitening, toothpaste and preparation method of toothpaste |
| CN107625659A (en) * | 2017-09-04 | 2018-01-26 | 美晨集团股份有限公司 | A kind of whitening toothpaste and preparation method thereof |
| CN110840813A (en) * | 2019-12-09 | 2020-02-28 | 上海绿瑞生物科技有限公司 | Whitening composition and application thereof |
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