CN115814266A - Electric field generating device - Google Patents

Abstract

The application relates to an electric field generating device, which comprises a processing module, a signal generating module and at least one electric field acting component which are connected in sequence, wherein the processing module is used for acquiring characteristic data of a target object and generating waveform parameters for stimulating the target object according to the characteristic data; the signal generation module is used for generating an electric field signal matched with the waveform parameters; the at least one electric field acting component is used for receiving the electric field signal to form a space electric field acting on the target object. The electric field generating device provided by the embodiment of the application can generate space electric fields with different electric field parameters such as different frequencies and different electric field strengths according to the characteristic data of the target object when acting on the target object, so as to meet the requirements of various electric field strengths or various working frequencies and the like when stimulating the target object, and enable the suppression effect to meet the requirements of personalized treatment.

Description

Electric field generating device

Technical Field

The application relates to the technical field of medical treatment, in particular to an electric field generating device.

Background

Electric field therapy (TTF), a new mode of cell therapy, is called electric field therapy. The cell electric field therapy can output alternating electric field with low intensity and medium frequency in a focus area to interfere the division process of cancer cells, so that the tumor cells are killed, and the aim of treatment is fulfilled. The basic principle of tumor electric field therapy is based on that the electric field has the effect of inhibiting and destroying the mitosis of tumor cells, and the electric field generated by the electric signal of 200kHz can be generally used for inhibiting the rapid growth of the tumor cells of a patient so as to achieve the therapeutic effect.

In the related art, electric field signals with a single frequency are often applied to tumor cells, but the application capability of the single frequency has certain limitations, and the single frequency cannot produce a high effect on inhibiting all types of tumor cells.

Disclosure of Invention

In view of the above, the present application provides an electric field generating apparatus, which can solve the technical requirement of the related art that the inhibition of tumor cells by using electric field signals with a single waveform parameter has limitations.

In a first aspect, an embodiment of the present application provides an electric field generating apparatus, which includes a processing module, a signal generating module, and at least one electric field acting component, which are connected in sequence,

the processing module is used for acquiring characteristic data of a target object and generating waveform parameters for stimulating the target object according to the characteristic data;

the signal generation module is used for generating an electric field signal matched with the waveform parameters;

the at least one electric field acting component is used for receiving the electric field signal to form a space electric field acting on the target object.

The electric field generating device provided by the embodiment of the application can be used for inhibiting mitosis of a target object such as tumor cells, and specifically, waveform parameters matched with characteristic data of the target object can be generated according to the characteristic data of the target object. The target object is different, and the corresponding characteristic data is different. Correspondingly, the waveform parameters of the electric field signals are different, and the generated space electric fields are also different. Therefore, when the electric field generating device is used for acting on the target object, the space electric fields with different electric field parameters, such as different frequencies and different electric field strengths, can be generated according to the characteristic data of the target object, so as to meet the requirements of stimulating the target object on various electric field strengths or various working frequencies and the like, and the inhibition effect meets the requirement of personalized treatment.

Optionally, in an embodiment of the present application, the electric field generating device is coupled to the terminal for receiving characteristic data of the target object.

Optionally, in an embodiment of the present application, the terminal is further configured to receive a reference waveform parameter input by a user; correspondingly, the processing module is further configured to generate waveform parameters for stimulating the target object according to the feature data and the reference waveform parameters.

Optionally, in an embodiment of the present application, the number of the signal generating modules is multiple, and the multiple signal generating modules are configured to generate electric field signals with different waveform parameters; correspondingly, the processing module is used for selecting the target signal generating module at the time of frequency switching, and the target signal generating module generates the electric field signal of the frequency to be switched before the time.

Optionally, in an embodiment of the present application, the signal generating module includes a plurality of registers, and the plurality of registers are used for storing waveform parameters of different electric field signals; the signal generating module is further configured to receive a waveform switching instruction sent by the processing module, and select a target register from the plurality of registers according to the waveform switching instruction, where the target register stores waveform parameters of an electric field signal with a frequency to be switched.

Optionally, in an embodiment of the present application, the feature data of the target object includes a cell size distribution ratio of the target object; correspondingly, the processing module is specifically configured to determine an action duration of a sensitive frequency or a sensitive frequency range corresponding to the target cell size in a unit cycle according to a distribution ratio of the target cell size, so that the action duration is positively correlated with the distribution ratio of the target cell size, so as to generate a waveform parameter for stimulating the target object.

Optionally, in an embodiment of the present application, the processing module is further configured to obtain a reference frequency and a reference frequency range; correspondingly, the processing module is used for generating the waveform parameters for stimulating the target object according to the reference frequency, the frequency variation range and the characteristic data.

Optionally, in an embodiment of the present application, the electric field generating apparatus further includes a visualization parameter configuration interface, and the visualization parameter configuration interface is configured to provide the user with an authority to input the reference waveform parameter and/or the feature data of the target object.

Optionally, in an embodiment of the present application, the electric field generating device further includes a temperature sensor connected to the electric field acting component, and the temperature sensor is connected to the processing module and configured to send the collected temperature information of the electric field acting component to the processing module; correspondingly, the processing module stops outputting the waveform parameters for stimulating the target object under the condition that the temperature information is determined to be greater than a preset temperature threshold value; correspondingly, the signal generation module stops outputting the electric field signal for stimulating the target object.

Optionally, in an embodiment of the present application, the electric field application component includes at least one set of electrode patches, each set of electrode patches is attached to a surface of the target object in different directions, so as to receive the electric field signal to form a spatial electric field that can penetrate through the target object.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.

FIG. 1 is a schematic block diagram of an electric field generating apparatus according to an embodiment;

FIG. 2 is a schematic diagram illustrating an electric field generating device coupled to a terminal according to one embodiment;

FIG. 3 is a diagram illustrating an application scenario according to one embodiment;

FIG. 4 is a block diagram illustrating a filtering block and a transforming block according to one embodiment;

FIG. 5 is a visualization parameter configuration interface schematic diagram shown in accordance with an embodiment.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be described and illustrated below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments provided in the present application without any inventive step are within the scope of protection of the present application. Moreover, it should be appreciated that such a development effort might be complex and tedious, but would nevertheless be a routine undertaking of design, fabrication, and manufacture for those of ordinary skill having the benefit of this disclosure, given the benefit of this disclosure, without departing from the scope of this disclosure.

Reference in the specification to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the specification. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of ordinary skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments without conflict.

Unless defined otherwise, technical or scientific terms referred to herein shall have the ordinary meaning as understood by those of ordinary skill in the art to which this application belongs. Reference to "a," "an," "the," and similar words throughout this application are not to be construed as limiting in number, and may refer to the singular or the plural. The present application is directed to the use of the terms "including," "comprising," "having," and any variations thereof, which are intended to cover non-exclusive inclusions; for example, a process, method, system, article, or apparatus that comprises a list of steps or modules (elements) is not limited to the listed steps or elements, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus. Reference to "connected," "coupled," and the like in this application is not intended to be limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. Reference herein to "a plurality" means greater than or equal to two. Reference herein to the terms "first," "second," "third," and the like, are merely to distinguish similar objects and do not denote a particular ordering for the objects.

Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present application. It will be understood by those skilled in the art that the present application may be practiced without some of these specific details. In some instances, devices, means, elements and circuits that are well known to those skilled in the art have not been described in detail so as not to obscure the present application.

The technical environment of the technical scheme of the application is described below. At present, taking tumor cells as an example, a tumor inhibiting electric field can periodically act on the tumor cells, prevent the formation of spindle microtubules and the separation of intracellular organelles in the cell division period during the mitosis process of the tumor cells, and induce the apoptosis of cells in the mitosis period so as to effectively destroy the mitosis of the tumor cells, thereby realizing the effect of inhibiting the proliferation of the tumor cells and achieving the purpose of treatment. The tumor cells may comprise malignant tissue of uncontrollable growing degenerative cells, among others. For example, lymphoma, myeloma, chordoma, angiosarcoma, lymphangiosarcoma, and the like may be included. In actual cell experiments, the electric field generated by the electric signal with the same waveform parameter is used for inhibiting the rapid growth of tumor cells at different positions or different sizes, and the inhibition effects are different. Obviously, the waveform parameters of the electric field signals applied to different tumor cells are different. For example, if a single frequency of electric field is used to inhibit different tumor cells, the inhibition may not be therapeutically effective. That is, the waveform parameters of the electric field signal applied to tumor cells are different.

Based on the technical environment, the electric field generating device provided by the application can adjust the waveform parameters of the electric field signals according to the characteristic data of the tumor cells in the process of treating different cells so as to generate different inhibition electric fields, so that the inhibition electric fields can inhibit different tumor cells, and the inhibition effect meets the treatment requirement.

Referring to fig. 1, fig. 1 is a schematic structural diagram illustrating an electric field generating apparatus 100 according to an embodiment of the present disclosure. Illustratively, the electric field generating apparatus 100 may comprise a processing module 101, a signal generating module 103, and at least one electric field acting part 105, which are connected in sequence, wherein,

the processing module 101 is configured to obtain feature data of a target object, and generate a waveform parameter for stimulating the target object according to the feature data;

the signal generation module 103 is configured to generate an electric field signal matched with the waveform parameter;

the at least one electric field application part 105 is configured to receive the electric field signal to form a spatial electric field applied to the target object.

In an embodiment of the present application, the target object may be a tissue or an organ of a human or animal body. Further, the target object may be a tumor cell, for example, a lung tumor cell, a stomach tumor cell, a lymphoid tumor cell, or the like. The characteristic data of the target object may be the size, the tissue or organ to which it belongs, the number, etc. of the target object. The processing module 101 may be an electronic device having data processing capability and data transceiving capability, for example, the processing module 101 may be a module capable of controlling waveform parameters of an electric field signal. Specifically, the Processing module 101 may include, but is not limited to, a Field Programmable Gate Array (FPGA), an Application Specific Integrated Circuit (ASIC), a Central Processing Unit (CPU), a Complex Programmable Logic Device (CPLD), a Micro Control Unit (MCU), a Data Signal Processor (DSP) or other Programmable Logic Device, a transistor Logic Device, and the like, and the type of the Processing module 101 is not limited herein. In one embodiment of the present application, the processing module 101 may obtain specific characteristic data of the target object, for example, directly obtain the tissue of the tumor cell as lung, the cell size as 16 μm, and the number as 1000. In other embodiments of the present application, the processing module 101 may also obtain a medical image of the target object and then perform analysis processing on the medical image to determine the feature data of the target object. The medical image may be a medical image obtained by an imaging device such as a CT scanning device, a PET scanning device, an MR scanning device, or a pathological section with respect to a target object. For example, the processing module 101 may pre-establish a medical image recognition model, which is trained by using a plurality of medical image samples. The medical image recognition model may include a model trained using machine learning. The machine learning mode may include a deep learning mode, a reinforcement learning mode, and the like, and the generated model may include a Convolutional Neural Network model (CNN), a Recurrent Neural Network model (RNN), leNet, resNet, a Long Short-Term Memory Network model (Long Short-Term Memory, LSTM), a bidirectional Long Short-Term Memory Network model (Bi-LSTM), and the like, which is not limited herein. The medical image recognition model may process a medical image of a target object and output corresponding feature data.

In an embodiment of the present application, the processing module 101 may directly obtain the feature data of the target object, or may indirectly obtain the feature data of the target object. For example, the characteristic data input by the user may be received through a terminal coupled to the electric field generating device 100. Specifically, as shown in fig. 2, the electric field generating apparatus 100 is coupled to a terminal 201 for receiving characteristic data of a target object.

In the embodiment of the present application, the terminal 201 is signal-coupled to the electric field generating apparatus 100, and is configured to receive a waveform parameter of a target object input by a user. The terminal 201 may be connected to the electric field generating apparatus 100 in a wired or wireless manner, and the wireless connection may include connection modes such as bluetooth and WIFI. The terminal 201 may be a smart phone, a tablet computer, a notebook computer, a desktop computer, a palm computer, a Mobile Internet Device (MID), a wearable Device (e.g., a smart watch, a smart bracelet, etc.), a smart computer, a smart car-mounted Device, etc., and the type of the terminal 201 is not limited herein. The user may directly input parameters and parameter values of specific feature data on the terminal 201, or may input only a medical image of a target object, and the like, and the processing module 101 performs analysis processing to determine final feature data. The user inputs the characteristic data of the target object to the electric field generating device 100 through the terminal 201, so that the interaction between the user and the electric field generating device 100 can be realized, and the requirement of personalized treatment of the user can be met.

In the embodiment of the present application, after the feature data of the target object is acquired, the waveform parameter for stimulating the target object may be generated according to the feature data. Different parameters of the stimulating electric field suitable for different target objects are different, and correspondingly, the waveform parameters of the electric field signal for generating the stimulating electric field are also different. The waveform parameters may include amplitude, frequency, peak value, effective value, duty cycle, and the like. In an embodiment of the application, the processing module 101 may preset a corresponding relationship between the feature data and the waveform parameter, so that after the feature data is determined, the corresponding waveform parameter may be determined according to the corresponding relationship. The correspondence relationship has a plurality of expression forms, and may include, for example, a correspondence relationship table, a correspondence function, a correspondence relationship model, and the like. In one example, the correspondence table of the characteristic data and the waveform parameter is shown in table 1 below.

TABLE 1 corresponding relationship table of characteristic data and waveform parameters

Characteristic data (organization and size)	Waveform parameters (frequency kHz, amplitude/V)
		Lung, 19 μm	200kHz、20V
Stomach, 25 μm	160kHz、50V

In one embodiment of the present application, in order to improve the efficiency and accuracy of determining the waveform parameters, the final waveform parameters may be determined by adjusting the reference waveform parameters input by the user. Specifically, the terminal 201 is further configured to receive a reference waveform parameter input by a user; correspondingly, the processing module 101 is further configured to generate waveform parameters for stimulating the target object according to the feature data and the reference waveform parameters.

In the embodiment of the present application, a user may input reference waveform parameters through the terminal 201, where the reference waveform parameters may be preset by the user according to actual treatment requirements and application scenarios. It is understood that the reference waveform parameters are waveform parameters set by a user, and may be adjusted according to the feature data of the target object in order to further determine more accurate waveform parameters. For example, when the size of the target object is larger, the frequency of the electric field signal may be reduced to obtain a better therapeutic effect. In an embodiment of the present application, the user may also input the waveform type, the action duration and the switching time through the terminal 201. The waveform type may include a linear type, a step type, an exponential type, and the like. The processing module 101, upon receiving the waveform type, duration of action, and switching time, may determine waveform parameters for stimulating the target object in conjunction with the characteristic data. For example, in one example, as shown in fig. 3, the waveform type selected by the user is a staircase type, the action time is 0-t3, and the switching time is t1, t2 (t 2=2 × t 1), t3 (t 2=3 × t 1). In the case where the maximum frequency of the waveform is fH and the minimum frequency is fL as determined from the feature data of the target object such as the cell size, it can be determined that the frequency change information of the waveform is f = fL + { (fc-fL)/t 1} × t within the action time period of 0-t 1; the frequency of the waveform is fixed and can be a reference frequency fc, i.e., f = fc, during the duration of action of t1-t 2. Wherein the reference frequency may be determined from the characteristic data, such as cell type.

In the embodiment of the present application, the signal generating module 103 may include a device capable of generating electrical signals with various frequencies, various waveforms, and output levels, for example, a device capable of generating sine waves, square waves, triangular waves, sawtooth waves, positive and negative pulse wave signals with different frequencies, and the like. And may specifically include, but is not limited to, a pulse signal generator, a function generator, a radio frequency generator, a microwave signal generator, and the like. Preferably, in an embodiment of the present application, the signal generating module 103 may include a Direct Digital Synthesizer (DDS), and the DDS may generate waveforms of different types, such as a sine wave, a triangular wave, a square wave, and a sawtooth wave, and has advantages of low cost, low power consumption, high resolution, and fast switching, so that fast switching of multiple waveform types or different waveform frequencies can be achieved, and efficient requirements in a tumor cell inhibition process are met. The signal generation module 103 may receive the waveform parameters sent by the processing module 101, and may generate an electric field signal matching the waveform parameters. The at least one electric field acting part 105 is coupled to the signal generating module 103, and can receive the electric field signal and form a space electric field acting on the target object. The coupling means may comprise a wired connection or a wireless connection. It will be appreciated that the electric field application component 105 may be directly connected or coupled to the signal generation module 103, or may be indirectly connected to the signal generation module 103 through intermediate elements, which may include, for example, filters, amplifiers, and the like. In an embodiment of the present application, as shown in fig. 4, the signal generating module 103 may be connected to a filtering module 107, and the filtering module 107 may perform low-pass filtering processing on the generated electric field signal, for example, set a suitable cut-off frequency to filter a harmonic part of a high-frequency signal in the electric field signal, where a waveform type and a frequency of the electric field signal before and after filtering do not change. The filtering module 107 is connected to the transforming module 109, and the transforming module 109 is configured to boost the filtered electric field signal and generate a target electric field signal. Moreover, because the voltage transformation module 109 only has a magnetic path and no electric path, the voltage transformation module 109 has an electric isolation function, and can isolate the high current of the input end from the output end, so that the output target electric field signal is a low current signal, thereby preventing the high current signal from damaging a human body and improving the personal safety guarantee of a user. It should be noted that, in an embodiment of the present application, the electric field generating apparatus 100 may further include a clock module 1011, where the clock module 1011 is connected to the signal generating module 103 and is used for providing a clock signal to the signal generating module 103.

In the embodiment of the present application, the electric field application part 105 may include a probe, an electrode patch, and the like. In the case where the electric field application member 105 is a probe, the electric field application member 105 may be inserted into a target object. The probe may include a plurality of electrodes that may contact a biological tissue or organ. In the case where the electric field application member 105 is an electrode patch, the electrode patches are paired and placed on the surface of the target object, for example, may be placed on the skin of the target object. It is understood that, in the case where the electric field application part 105 is an electrode patch, a spatial electric field penetrating the target object can be formed, so that mitosis of cells can be effectively inhibited, and a therapeutic effect can be improved.

The electric field generating apparatus 100 provided by the embodiment of the present application can be used for inhibiting mitosis of a target object, such as a tumor cell, and specifically, can generate waveform parameters matched with characteristic data of the target object according to the characteristic data. The target object is different, and the corresponding characteristic data is different. Correspondingly, the waveform parameters of the electric field signals are different, and the generated space electric fields are also different. Thus, when the electric field generating device 100 is used for acting on a target object, a spatial electric field with different electric field parameters, such as different frequencies and different electric field intensities, can be generated according to the characteristic data of the target object, so as to meet the requirements of various electric field intensities or various working frequencies and the like when the target object is stimulated, and the inhibition effect meets the requirements of personalized treatment.

In order to accurately determine the waveform parameters of the electric field signal and the frequency variation of the electric field signal, in one embodiment of the present application, the characteristic data of the target object includes a cell size distribution ratio of the target object; correspondingly, the processing module 101 is specifically configured to determine an action duration of a sensitive frequency or a sensitive frequency range corresponding to a target cell size in a unit cycle according to a distribution ratio of the target cell size, so that the action duration is positively correlated with the distribution ratio of the target cell size, so as to generate a waveform parameter for stimulating the target object.

In the embodiment of the present application, the cell distribution ratio of the target object may be determined according to the feature data. The cell distribution ratio of the target subject may include the ratio of the number of tumor cells of different sizes to the total number of tumor cells. For example, in one example, the distribution of cell sizes a is 30%, the distribution of cell sizes B is 20%, and the distribution of cell sizes C is 50%. In determining the distribution ratio, the processing module 101 may control an action duration of a sensitive frequency or a sensitive frequency range corresponding to the target cell size in a unit cycle according to the distribution ratio of the target cell size, so that the action duration is in positive correlation with the distribution ratio of the target cell size. Wherein the sensitivity frequency range may include a fluctuation above and below a sensitivity frequency point corresponding to the target cell size. The positive correlation means that the action time is increased in the case where the distribution ratio of the target cell size is increased. In one embodiment, the positive correlation may comprise a positive correlation of the length of action versus the cell size distribution. For example, in one example, in a case where the distribution ratio of the cell size a is 30%, the distribution ratio of the cell size B is 20%, and the distribution ratio of the cell size C is 50%, if the unit cycle of the electric field signal is 60s, the action time period of the sensitive frequency corresponding to the cell size a is 18s, the action time period of the sensitive frequency corresponding to the cell size B is 12s, and the action time period of the sensitive frequency corresponding to the cell size a is 30s. It should be noted that the frequency variation of the electric field signal may be continuous or discrete. In one embodiment of the present application, after determining the corresponding action durations of different cell size distribution ratios, the processing module 101 may fit a plurality of discrete action durations, so that the frequency change of the electric field signal is continuous.

With the above embodiment, the processing module 101 may determine the action duration of the sensitive frequency or the sensitive frequency range corresponding to each cell size according to each cell size distribution ratio, so that the action duration is in positive correlation with the size distribution ratio. Thus, the action time of the sensitive frequency corresponding to the cell size with larger cell size distribution is longer, so that the division of the part of cells can be fully inhibited by the electric field generated by the electric field generating device 100, and a better treatment effect can be obtained. On the other hand, the action duration of the sensitive frequency corresponding to the cell size with less cell size distribution is shorter, so that the harm of electric field radiation to a human body is reduced while cell division is inhibited, and the use experience of a user is improved. In summary, the spatial electric field generated by the electric field generating apparatus 100 can enhance the suppression efficiency while most of the tumor cell mitosis is sufficiently suppressed by the spatial electric field.

In order to save computation time and improve the efficiency of controlling the frequency variation of the electric field signal, in another embodiment of the present application, the frequency variation may be simply and quickly determined according to the acquired reference frequency and the reference frequency range. Specifically, the processing module 101 is further configured to obtain a reference frequency and a reference frequency range; correspondingly, the processing module 101 is configured to generate the waveform parameters for stimulating the target object according to the reference frequency, the frequency variation range and the feature data.

In the embodiment of the present application, the reference frequency may be a reference frequency of the electric field signal, for example, a sensitive frequency reference point found by a method for selecting a sensitive frequency based on the characteristic data. The reference frequency may be determined, for example, based on the cell type to which the target object corresponds. In one example, four types of lung tumor cells are common, A549, MSTO-211H, NCI-H1299, and NCI-H2052, all with an applicable sensitivity frequency of 150kHz. Thus, in case the cell type is determined to be lung, the reference frequency can be determined to be 150kHZ. It should be noted that the reference frequency may be a reference frequency input by the user through the terminal, or may be a reference frequency determined by the processing module 101 according to the feature data or the cell size distribution ratio. In one embodiment of the present application, the reference frequency range may include a frequency range encompassed by a maximum frequency and a minimum frequency of the electric field signal. Wherein the minimum frequency may comprise a first sensitive frequency corresponding to a cell size smaller than a first preset size threshold. The first preset size threshold may be determined by a user according to actual application requirements, for example, the first preset size threshold may include a size corresponding to a cell with a largest cell size in the target object, and may also include a size determined according to several cell sizes with a larger cell size in the target object, such as an average value, a median, and the like. After determining the cell size smaller than the first preset threshold, the first sensitive frequency may be determined according to a correspondence between the cell size and the sensitive frequency. The corresponding relation can be set by a user according to an actual experiment result. The correspondence may be represented by a correspondence table, a correspondence function, and a correspondence model, which is not limited herein. Correspondingly, the maximum frequency may include a second sensitive frequency corresponding to a cell size greater than a second predetermined size threshold. The second preset size threshold is determined by the same method as the first preset size threshold, but the first preset size threshold is different from the second preset size threshold in value, and the first preset size threshold is larger than the second preset size threshold. Of course, in other embodiments of the present application, the maximum frequency and the minimum frequency may be set to constant values by a user according to empirical values and basic theory, for example, the maximum frequency may be set to the reference frequency +20kHz, and the minimum frequency may be set to the reference frequency-20 kHz. It should be noted that the reference frequency range may be a reference frequency range input by the user through the terminal, or the reference frequency range determined by the processing module 101 according to the feature data or the cell size distribution ratio.

In order to improve the generation efficiency of the electric field signal and the fast switching efficiency of the electric field signals with different frequencies, the electric field generating apparatus 100 may include a plurality of signal generating modules 103, and the plurality of signal generating modules 103 are used alternately to generate the electric field signal with a frequency varying continuously. Specifically, in one embodiment of the present application, the number of the signal generating modules 103 is multiple, and multiple signal generating modules 103 are used for generating electric field signals with different waveform parameters; correspondingly, the processing module 101 is configured to select the target signal generating module 103 at a time of frequency switching, and the target signal generating module 103 generates an electric field signal of a frequency to be switched before the time.

In this embodiment, the signal generating modules 103 may generate electric field signals with different waveform parameters. Specifically, the processing module 101 may send different waveform parameters to different signal generating modules 103, and the different signal generating modules 103 may generate corresponding electric field signals according to the different waveform parameters. For example, the signal generation module 103-a generates the electric field signal a, the signal generation module 103-B may generate the electric field signal B, and the waveform parameters of the electric field signal a and the electric field signal B may be different. In one embodiment of the present application, the optimal electric field frequency for the target object is different due to the different cell types or sizes of the target object. Therefore, a frequency parameter of the waveform parameters needs to be switched over time, for example, the frequency of the electric field signal at the time t1 is different from the frequency at the time t 2. On this basis, in order to improve the frequency switching efficiency, the processing module 101 may select the corresponding signal generating module 103 according to the difference of the frequency. Since the plurality of signal generators generate the electric field signals with a plurality of different waveform parameters in advance, the processing module 101 may select the target signal generation module 103 from the plurality of signal generation modules 103 at the time of switching the frequency, where the frequency of the electric field signal generated by the target signal generation module 103 is the same as the frequency to be switched. In an embodiment of the present application, the processing module 101 may control the switching of the signal generating module by controlling the on and off of a control switch connected to the signal generating module 103. It is understood that the frequency variation range of the electric field signal is wide due to the difference of the characteristic data of the target object. That is, the frequency of the electric field signal in a unit period is varied, and if more signal generating modules 103 are provided, the cost is increased, and the switching efficiency cannot be expected. On this basis, a fixed number of signal generation modules 103 may be provided, so that the waveform parameters of the electric field signals generated by the fixed number of signal generation modules 103 change with the change of the switching timing. Specifically, in one example, the electric field generating apparatus 100 includes a signal generating module 103-a and a signal generating module 103-B, and when the unit period is 100ms, the frequency of the electric field signal A1 generated by the signal generating module 103-a is A1 and the frequency of the electric field signal B1 generated by the signal generating module 103-B is B1 at the action time 1 ms. When the acting time is 2ms, the signal generation module 103 generating the electric field signal can be switched from the signal generation module 103-a to the signal generation module 103-B, and the frequency of the electric field signal A2 generated by the signal generation module 103-a is set to A2 in advance. Therefore, when the action time is 3ms, the frequency of the electric field signal can be quickly switched to A2 by switching the signal generation module 103-B to the signal generation module 103-A, so that the electric field signal with continuous frequency change can be generated circularly, and the frequency change trend is matched with the waveform parameters.

In the above embodiment, a plurality of signal generating modules 103 may be disposed in the electric field generating apparatus 100, and the frequencies of the electric field signals generated by the plurality of signal generating modules 103 are different. Thus, the target signal generating module 103 can be selected from the plurality of signal generating modules 103 at the time of frequency switching, so that the frequency of the generated electric field signal meets the treatment requirement, and the frequency switching efficiency is improved.

Of course, in other embodiments of the present application, the register in the signal generating module 103 may also store the waveform parameters of the required electric field signal in advance, so that the corresponding electric field signal may be generated quickly when the frequency switching instruction is received, thereby further optimizing the therapeutic effect of the electric field generating apparatus 100. Specifically, in an embodiment of the present application, the signal generating module 103 includes a plurality of registers, and the plurality of registers are used for storing waveform parameters of different electric field signals; the signal generating module 103 is further configured to receive a waveform switching instruction sent by the processing module 101, and select a target register from the plurality of registers according to the waveform switching instruction, where the target register stores waveform parameters of an electric field signal with a frequency to be switched.

In this embodiment, the signal generating module 103 may include a plurality of registers, and the plurality of registers may receive and store the waveform parameters sent by the processing module 101 in advance. The processing module 101 may send a waveform switching instruction according to an actual treatment requirement or a time variation of a unit cycle, where the waveform switching instruction may include a waveform parameter that needs to be switched. The signal generation module 103 may determine, after receiving the waveform switching instruction, a target register corresponding to the waveform parameter included in the waveform switching instruction from a plurality of registers. That is, the target register stores therein a waveform parameter corresponding to the waveform switching instruction. In an embodiment of the present application, the processing module 101 may send the waveform switching instruction through a fsselect pin between the processing module and the signal generating module 103. It is understood that, after selecting the target register, the signal generating module 103 may control the target register to generate a corresponding electric field signal according to the pre-stored waveform parameters, so as to perform subsequent processing on the electric field signal.

In one embodiment of the present application, the electric field generating apparatus 100 further comprises a visualization parameter configuration interface for providing a user with permission to input the reference waveform parameters and/or the characteristic data of the target object.

In the embodiment of the application, the visualization logic configuration interface may include a plurality of data input boxes, and the functions corresponding to the plurality of data input boxes are respectively marked. On the basis, the user can fill the corresponding reference waveform parameters or characteristic data into the data input boxes according to the requirement. Of course, the visualization logic configuration interface may further include a control, and the control may include a trigger button such as "determine" or the like, which is interacted with by a user. Of course, the visualization logic configuration interface may also store and display the parameters of each parameter area in a table form, which is not limited herein. The visual logic configuration interface may be displayed on the client or the terminal, which is not limited herein. Specifically, in an example, as shown in fig. 5, the visualization parameter configuration interface 500 may be used to provide the user with the authority to input the characteristic data of the target object, such as the cell type and the cell size, and also provide the user with the authority to input the waveform parameters, such as the reference frequency and the output power.

By the embodiment, the characteristic data of the reference waveform parameter and/or the target object can be acquired through the visual logic configuration interface, so that the subsequent waveform parameter determination is simpler, and the use experience of a user is improved.

In practical applications, since the electric field applying part 105 applies a certain amount of heat to the contact surface during the process of applying the target object, the temperature of the contact surface gradually increases. Considering that there is a certain maximum tolerated temperature in both human or animal body, if the temperature of the skin surface of the human or animal body exceeds this maximum tolerated temperature, discomfort may be caused, thereby reducing the experience of the human or animal body. Based on this, in an embodiment of the present application, the electric field generating apparatus 100 further includes a temperature sensor connected to the electric field acting part 105, the temperature sensor is connected to the processing module 101, and is configured to transmit the collected temperature of the electric field acting part 105 to the processing module 101; correspondingly, the processing module 101 stops outputting the waveform parameters for stimulating the target object when it is determined that the temperature is greater than a preset temperature threshold; correspondingly, the signal generation module 103 stops outputting the electric field signal for stimulating the target object.

In the embodiment of the present application, a temperature sensor may be provided in the electric field generating apparatus 100. For example, in one example, as shown in fig. 4, in the case where the electric field application member 105 is an electrode patch, the temperature sensor 1013 may be placed against the electrode patch to collect the temperature generated by the electrode patch. The temperature sensor 1013 may include a thermistor, a Resistance Temperature Detector (RTD), a thermocouple, and the like. In one embodiment of the present application, the temperature sensor 1013 is connected to the processing module 101, and is configured to transmit the collected temperature of the electric field application part 105 to the processing module 101. The temperature may be a specific value, such as 35 degrees celsius, 36 degrees celsius, 37 degrees celsius, or may be a temperature level, such as a medium temperature, a high temperature, or the like. The processing module 101 may determine in real time whether the received temperature is greater than a preset temperature threshold, so as to stop outputting in time to prevent scalding when the temperature is greater than the preset temperature threshold. The preset temperature threshold may be set by a user according to an actual application scenario and common living knowledge, for example, may be set to 41 degrees celsius. It is understood that the processing module 101 may re-output the waveform parameters to generate the electric field signal when it is determined that the temperature collected by the temperature sensor is less than the preset temperature threshold or the set temperature is, for example, 36 degrees celsius.

Further, in an embodiment of the present application, the electric field application part 105 includes at least one set of electrode patches, each set of electrode patches is attached to a surface of the target object in different directions, so as to receive the electric field signal to form a spatial electric field capable of penetrating through the target object.

In the embodiment of the present application, two electrode patches in a group of electrode patches are located at opposite positions of a target object, and a spatial electric field penetrating through the target object can be formed. In one embodiment of the present application, in order to improve coverage, flexibility or adaptability of the spatial electric field to the target object, in one embodiment of the present application, the sets of electrodes may be attached to the surface of the target object in different directions, so as to form the spatial electric field that can penetrate through the target object in different directions. For example, as shown in fig. 4, the electrode patches B and D may be relatively attached to the surface of the target object in the x-axis direction; the electrode patches A and C can be oppositely attached to the surface of the target object in the y-axis direction.

The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of apparatus, systems, methods according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of instructions, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. An electric field generating device is characterized by comprising a processing module, a signal generating module and at least one electric field acting component which are connected in sequence,

the processing module is used for acquiring characteristic data of a target object and generating waveform parameters for stimulating the target object according to the characteristic data;

the signal generation module is used for generating an electric field signal matched with the waveform parameters;

the at least one electric field acting component is used for receiving the electric field signal to form a space electric field acting on the target object.

2. The electric field generating apparatus according to claim 1, wherein the electric field generating apparatus is coupled to a terminal for receiving characteristic data of a target object.

3. The electric field generating apparatus according to claim 2, wherein the terminal is further configured to receive a reference waveform parameter input by a user; correspondingly, the processing module is further configured to generate waveform parameters for stimulating the target object according to the feature data and the reference waveform parameters.

4. The electric field generating device according to claim 1, wherein the number of the signal generating modules is plural, and the plural signal generating modules are used for generating electric field signals with different waveform parameters; correspondingly, the processing module is used for selecting the target signal generating module at the time of frequency switching, and the target signal generating module generates the electric field signal of the frequency to be switched before the time.

5. The electric field generating device according to claim 1, wherein the signal generating module comprises a plurality of registers for storing waveform parameters of different electric field signals; the signal generating module is further configured to receive a waveform switching instruction sent by the processing module, and select a target register from the plurality of registers according to the waveform switching instruction, where the target register stores waveform parameters of an electric field signal with a frequency to be switched.

6. The electric field generating apparatus according to claim 1, wherein the characteristic data of the target object includes a cell size distribution ratio of the target object; correspondingly, the processing module is specifically configured to determine an action duration of a sensitive frequency or a sensitive frequency range corresponding to the target cell size in a unit cycle according to a distribution ratio of the target cell size, so that the action duration is positively correlated with the distribution ratio of the target cell size, so as to generate a waveform parameter for stimulating the target object.

7. The electric field generating apparatus according to claim 6, wherein the processing module is further configured to obtain a reference frequency and a reference frequency range; correspondingly, the processing module is used for generating the waveform parameters for stimulating the target object according to the reference frequency, the frequency variation range and the characteristic data.

8. The electric field generation device according to claim 1, further comprising a visualization parameter configuration interface for providing a user with permission to input reference waveform parameters and/or characteristic data of a target object.

9. The electric field generating device according to claim 1, further comprising a temperature sensor connected to the electric field acting part, wherein the temperature sensor is connected to the processing module, and is configured to send the collected temperature of the electric field acting part to the processing module; correspondingly, the processing module stops outputting the waveform parameters for stimulating the target object when the temperature is determined to be greater than a preset temperature threshold; correspondingly, the signal generation module stops outputting the electric field signal for stimulating the target object.

10. The electric field generating apparatus according to claim 1, wherein the electric field acting member comprises at least one set of electrode patches, each set of electrode patches is attached to the surface of the target object in different directions, so as to receive the electric field signal and form a spatial electric field capable of penetrating through the target object.

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