KR20150062584A - Feedback brain stimuation device controlling in periodic and non-periodic mode - Google Patents

Feedback brain stimuation device controlling in periodic and non-periodic mode Download PDF

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KR20150062584A
KR20150062584A KR1020130147396A KR20130147396A KR20150062584A KR 20150062584 A KR20150062584 A KR 20150062584A KR 1020130147396 A KR1020130147396 A KR 1020130147396A KR 20130147396 A KR20130147396 A KR 20130147396A KR 20150062584 A KR20150062584 A KR 20150062584A
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unit
periodic
pulse
neural signal
brain
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Korean (ko)
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신현출
안혜진
유경진
강기문
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숭실대학교산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36125—Details of circuitry or electric components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems

Abstract

The present invention relates to a brain electrostimulation device capable of controlling in a periodic or non-periodic mode. The brain electrostimulation device comprises: one or more neural signal measuring unit for measuring a neural signal generated by neural activities of the brain; an amplifying unit for amplifying the measured neural signal; an AD convertor unit for converting the amplified analog-type neural signal into a digital signal; a neural signal analyzing unit for storing and analyzing the converted digital neural signal; a power generating unit for generating high frequency power and standard power; a memory unit for storing an electrostimulation pulse model to be generated using the power; a pulse control unit for controlling a shape of an output pulse based on the pulse model stored in the memory unit; and a mode settting unit for setting a mode for controlling the output pulse in a periodic wave or non-periodic wave type. According to the present invention, a pulse according to electrostimulation may be controlled in a periodic/non-periodic mode. Moreover, a feedback loop is applied for input and output, thereby sending an optimal electrostimulation pulse to the brain.

Description

주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치{FEEDBACK BRAIN STIMUATION DEVICE CONTROLLING IN PERIODIC AND NON-PERIODIC MODE}BACKGROUND OF THE INVENTION Field of the Invention [0001] The present invention relates to a feedback brain electrical stimulation device capable of controlling a periodic and non-

본 발명은 뇌에 전기자극을 발생시키는 뇌 전기자극 장치에 관한 것으로, 더욱 상세하게는 컴퓨터에 의하여 주기 및 비주기 펄스 제어가 가능한 피드백 뇌 전기자극 장치에 관한 것이다.BACKGROUND OF THE INVENTION Field of the Invention [0001] The present invention relates to a brain electrical stimulation apparatus that generates electrical stimulation in the brain, and more particularly, to a feedback brain electrical stimulation apparatus capable of periodic and non-periodic pulse control by a computer.

뇌 중추신경계에 대한 전기적 자극에 관하여서는 오랜 기간동안 연구가 진행되어 왔다. 연구 초기의 전기적 자극은 반복되는 간질이 발생되는 부분을 찾거나 수술중 뇌기능부의 특히 운동영역, 언어영역 등 뇌의 특정한 부분에 대한 기능적 지도를 얻는데 사용되었다.Electrical stimulation of the central nervous system has been studied for a long period of time. Electrical stimulation at the beginning of the study was used to find areas where repetitive epilepsy occurred, or to obtain functional maps of specific areas of the brain such as the motor area and language area, especially during surgery.

최근, 반복적경두개자기자극(repetitive transcranial magnetic stimulation: rTMS) 및 경두개직류전기자극(transcranial direct current stimulation: tDCS)을 통한 뇌 전자기자극 연구에 의하면 우울증, 파킨슨씨병, 뇌졸중 후 기능 손상, 간질, 만성 신경병증성 통증 등의 치료에 효과가 있음이 밝혀졌다.Recently, brain electromagnetic stimulation studies using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have shown that depression, Parkinson's disease, post-stroke functional impairment, Neuropathic pain and the like.

특히 뇌에 전기자극을 가하면 치매 증상을 완화시킬 수 있다는 연구결과가 나와 주목을 받고 있다. 치매 환자는 해마가 축소되고 해마가 포함된 측두엽과 기억기능에 중요한 역할을 하는 또 다른 부위인 후대상회의 포도당 사용이 정상이하로 줄어든다.In particular, research has shown that electrical stimulation of the brain can alleviate symptoms of dementia. In dementia patients, the hippocampus is reduced, and temporal lobes, including the hippocampus, and other areas of important memory function, are reduced to sub-normal glucose use.

해마에 전기파를 보내 전기 자극이 치매의 예방 또는 치료에 미치는 영향을 파악하는 데에 있어서 기존의 기술은 단순한 주기적인 펄스를 보내는 것에 한정되어 있었다.Conventional techniques have been limited to sending simple periodic pulses in determining the effect of electrical stimulation on the prevention or treatment of dementia by sending electrical waves to the hippocampus.

본 발명의 배경이 되는 기술은 대한민국 공개특허공보 제10-2011-006407호(2011.06.15)에 기재되어 있다.BACKGROUND OF THE INVENTION [0002] The art of the present invention is disclosed in Korean Patent Laid-Open Publication No. 10-2011-006407 (June 15, 2011).

본 발명이 해결하고자 하는 과제는, 주기/비주기 모드에서 제어가 가능한 피드백 뇌 전기자극 장치를 제공하는 것이다.SUMMARY OF THE INVENTION It is an object of the present invention to provide a feedback brain electrical stimulation apparatus which can be controlled in periodic / aperiodic mode.

상기한 바와 같은 목적을 달성하기 위한 본 발명의 실시예에 따른 주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치는, 뇌의 신경활동으로 발생하는 신경신호를 측정하는 하나 이상의 신경신호 측정부; 측정된 상기 신경신호를 증폭하는 증폭부; 상기 증폭된 아날로그 형태의 신경신호를 디지털 신호로 변환하는 AD 컨버터부; 상기 변환된 디지털 신경신호를 저장하여 분석하는 신경신호 분석부; 고주파 전원과 기준 전원을 발생시키는 전원발생부; 상기 전원을 이용하여 발생시키려는 전기 자극 펄스 모델이 저장되어 있는 메모리부; 상기 메모리부에 저장되어 있는 펄스 모델을 기초로 출력 펄스의 모양을 제어하는 펄스 제어부; 및 상기 출력 펄스를 주기파 또는 비주기 파 형태로 제어하기 위해 모드를 설정하는 모드 설정부를 포함한다.According to an aspect of the present invention, there is provided a feedback brain electrical stimulation apparatus capable of controlling a periodic and an aperiodic mode, comprising: at least one neural signal measuring unit for measuring a neural signal generated by a neural activity of the brain; ; An amplifying unit for amplifying the measured neural signal; An AD converter for converting the amplified analog type neural signal into a digital signal; A neural signal analyzer for storing and analyzing the converted digital neural signal; A power generator for generating a high frequency power source and a reference power source; A memory unit for storing an electrical stimulation pulse model to be generated using the power supply; A pulse control unit for controlling the shape of the output pulse based on the pulse model stored in the memory unit; And a mode setting unit for setting a mode for controlling the output pulse in the form of a periodic wave or an aperiodic wave.

또한, 상기 뇌 전기자극 장치는 PC와 연결되는 보드 형태로서 USB 포트와 PC 통신부를 더 포함할 수 있다.In addition, the brain electrical stimulation apparatus may further include a USB port and a PC communication unit as a board type connected to a PC.

또한, 발생되는 전기자극 펄스를 증폭하는 증폭부를 더 포함할 수 있다.The apparatus may further include an amplifying unit for amplifying the generated electric stimulation pulse.

본 발명인 주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치는, 전기 작극에 따른 펄스를 주기/비주기 모드에서 제어가 가능하다.The feedback brain electric stimulation apparatus which can be controlled in the periodic and aperiodic modes of the present invention is capable of controlling pulses according to electric stimulation in a periodic / non-periodic mode.

또한, 입력과 출력에서 피드백 루프를 적용하여 최적의 전기자극 펄스를 뇌에 보낼 수 있다.In addition, a feedback loop can be applied at the input and at the output to send the optimal electrical stimulation pulse to the brain.

도 1은 본 발명의 실시예에 따른 주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치의 하드 웨어 구성도이다.
도 2 내지 도 10은 본 발명의 실시에에 따른 주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치를 이용한 뇌 전기자극 장치의 회로도이다.1 is a hardware configuration diagram of a feedback brain electrical stimulation apparatus that can be controlled in a periodic and an aperiodic mode according to an embodiment of the present invention.
2 to 10 are circuit diagrams of a brain electrical stimulation apparatus using a feedback brain electrical stimulation apparatus which can be controlled in periodic and non-periodic modes according to an embodiment of the present invention.

이하에서는 첨부한 도면을 참조하여 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 본 발명의 실시예를 상세히 설명한다. 그러나 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며 여기에서 설명하는 실시예에 한정되지 않는다. 그리고 도면에서 본 발명을 명확하게 설명하기 위해서 설명과 관계없는 부분은 생략하였으며, 명세서 전체를 통하여 유사한 부분에 대해서는 유사한 도면 부호를 붙였다.Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and similar parts are denoted by like reference characters throughout the specification.

먼저 본 발명의 주기 및 비주기 모드로 제어가 가능한 뇌 전기자극 장치에 대하여 설명한다.First, a brain electrical stimulation apparatus capable of controlling the period and the aperiodic mode of the present invention will be described.

도 1은 본 발명의 실시예에 따른 주기 및 비주기 모드로 제어가 가능한 뇌 전기자극 장치의 하드웨어 구성도이다.1 is a hardware block diagram of a brain electrical stimulation apparatus that can be controlled in periodic and non-periodic modes according to an embodiment of the present invention.

도 1에 도시된 바와 같이, 주기 및 비주기 모드로 제어가 가능한 뇌 전기자극 장치는, 신경신호 측정부, 증폭부, AD 컨버터부, 신경신호 분석부, 전원발생부, 메모리부, 제어부 및 모드 설정부를 포함한다.As shown in FIG. 1, a brain electrical stimulation apparatus that can be controlled in a periodic and an aperiodic mode includes a neural signal measuring unit, an amplifying unit, an AD converter unit, a neural signal analyzing unit, a power generating unit, a memory unit, And a setting unit.

최대 4개의 채널 사용 가능하며, 채널 별 독립적으로 on/off, 주기/비주기 및 신호 수치를 설정할 수 있는 뇌 자극기이다. 이에 대한 제어는 뇌 자극기 장치와 컴퓨터를 USB 케이블로 연결한 후, 컴퓨터 프로그램을 통해 할 수 있다.It is a brain stimulator that can use up to 4 channels and can independently set on / off, period / non-period and signal value for each channel. The control can be done through a computer program after connecting the brain stimulator device to the computer with a USB cable.

S/W는 두 개의 창으로 구성되며, 하나의 창에서는 가공되지 않은 Raw data를 사용자가 직접 눈으로 확인할 수 있다. 다른 한 창에서는 자극 신호에 대한 제어를 할 수 있다. 채널 별로 on/off, 주기/비주기 및 신호 수치를 설정할 수 있으며 사용자가 원한다면 채널 1에서 입력한 수치를 버튼 하나로 나머지 채널에 동일하게 적용시킬 수 있다.S / W consists of two windows. In one window, raw raw data can be visually checked by the user. In the other window, you can control the stimulus signal. You can set on / off, cycle / non-period and signal values for each channel, and if you want, you can apply the same value to the remaining channels with one button.

Periodic Mode, Non-periodic Mode 모두에서 펄스 폭과 크기, 반복 횟수 등을 주어진 범위 내에서 지정할 수 있으며, 특히, Non-periodic Mode에서는 펄스 시작 시간을 메모장 파일을 이용하여 사용자 임의로 지정할 수 있다. 두 모드에서 수치를 지정하면 자극 신호의 특징이 보이는 그래프가 표시되며, Start/Stop 버튼으로 이 자극 신호를 전달하거나 강제로 중지 가능하다.In both periodic mode and non-periodic mode, pulse width, size, repetition frequency, etc. can be specified within a given range. In non-periodic mode, pulse start time can be arbitrarily designated by user using notepad file. If you specify a numeric value in both modes, a graph showing the characteristics of the stimulus signal is displayed. You can transmit or stop this stimulus signal with the Start / Stop button.

이와 같이 본 발명의 실시예에 따른 주기 및 비주기 모드로 제어가 가능한 피드백 뇌 전기자극 장치에 따르면, 전기 작극에 따른 펄스를 주기/비주기 모드에서 제어가 가능하다.As described above, according to the feedback brain electric stimulation apparatus capable of controlling the periodic and the aperiodic modes according to the embodiment of the present invention, it is possible to control the pulse according to the electric stimulation in the periodic / non-periodical mode.

또한, 입력과 출력에서 피드백 루프를 적용하여 최적의 전기자극 펄스를 뇌에 보낼 수 있다.In addition, a feedback loop can be applied at the input and at the output to send the optimal electrical stimulation pulse to the brain.

이제까지 본 발명에 대하여 실시예들을 중심으로 살펴보았다. 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자는 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 구현될 수 있음을 이해할 수 있을 것이다. 그러므로 개시된 실시예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 한다. 따라서 본 발명의 범위는 전술한 실시예에 한정되지 않고 특허청구범위에 기재된 내용 및 그와 동등한 범위 내에 있는 다양한 실시 형태가 포함되도록 해석되어야 할 것이다.The present invention has been described above with reference to the embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. Therefore, the scope of the present invention is not limited to the above-described embodiments, but should be construed to include various embodiments within the scope of the claims and equivalents thereof.

Claims (3)

뇌의 신경활동으로 발생하는 신경신호를 측정하는 하나 이상의 신경신호 측정부;
측정된 상기 신경신호를 증폭하는 증폭부;
상기 증폭된 아날로그 형태의 신경신호를 디지털 신호로 변환하는 AD 컨버터부;
상기 변환된 디지털 신경신호를 저장하여 분석하는 신경신호 분석부;
고주파 전원과 기준 전원을 발생시키는 전원발생부;
상기 전원을 이용하여 발생시키려는 전기 자극 펄스 모델이 저장되어 있는 메모리부;
상기 메모리부에 저장되어 있는 펄스 모델을 기초로 출력 펄스의 모양을 제어하는 펄스 제어부; 및
상기 출력 펄스를 주기파 또는 비주기 파 형태로 제어하기 위해 모드를 설정하는 모드 설정부를 포함하는 뇌 전기자극 장치.At least one neural signal measuring unit for measuring a neural signal generated by a neural activity of the brain;
An amplifying unit for amplifying the measured neural signal;
An AD converter for converting the amplified analog type neural signal into a digital signal;
A neural signal analyzer for storing and analyzing the converted digital neural signal;
A power generator for generating a high frequency power source and a reference power source;
A memory unit for storing an electrical stimulation pulse model to be generated using the power supply;
A pulse control unit for controlling the shape of the output pulse based on the pulse model stored in the memory unit; And
And a mode setting unit for setting a mode for controlling the output pulse in a periodic wave or an aperiodic wave form. 제 1항에 있어서,
상기 뇌 전기자극 장치는 PC와 연결되는 보드 형태로서 USB 포트와 PC 통신부를 더 포함하는 뇌 전기자극 장치.The method according to claim 1,
Wherein the brain electrical stimulation apparatus further comprises a USB port and a PC communication unit in the form of a board connected to the PC. 제 1항에 있어서,
발생되는 전기자극 펄스를 증폭하는 증폭부를 더 포함하는 뇌 전기자극 장치.The method according to claim 1,
And an amplification unit for amplifying the generated electric stimulation pulse.
KR1020130147396A 2013-11-29 2013-11-29 Feedback brain stimuation device controlling in periodic and non-periodic mode KR20150062584A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020163177A1 (en) * 2019-02-04 2020-08-13 The Johns Hopkins University Phase-dependent brain neuromodulation of cross-frequency coupling
CN112965595A (en) * 2021-02-26 2021-06-15 清华大学深圳国际研究生院 Modeling and predicting method for simulating touch by nerve electrical stimulation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020163177A1 (en) * 2019-02-04 2020-08-13 The Johns Hopkins University Phase-dependent brain neuromodulation of cross-frequency coupling
CN112965595A (en) * 2021-02-26 2021-06-15 清华大学深圳国际研究生院 Modeling and predicting method for simulating touch by nerve electrical stimulation
CN112965595B (en) * 2021-02-26 2023-09-05 清华大学深圳国际研究生院 Modeling and predicting method for nerve electrical stimulation simulation touch sense

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