CN115803689A - 时间测量装置、荧光寿命测量装置及时间测量方法 - Google Patents
时间测量装置、荧光寿命测量装置及时间测量方法 Download PDFInfo
- Publication number
- CN115803689A CN115803689A CN202180046560.9A CN202180046560A CN115803689A CN 115803689 A CN115803689 A CN 115803689A CN 202180046560 A CN202180046560 A CN 202180046560A CN 115803689 A CN115803689 A CN 115803689A
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- time
- signal
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Links
- 238000000034 method Methods 0.000 title claims description 16
- 238000005259 measurement Methods 0.000 claims abstract description 191
- 238000001514 detection method Methods 0.000 claims abstract description 93
- 230000001360 synchronised effect Effects 0.000 claims description 15
- 238000000691 measurement method Methods 0.000 claims description 8
- 230000000875 corresponding effect Effects 0.000 claims 8
- 230000001276 controlling effect Effects 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 23
- 238000010586 diagram Methods 0.000 description 10
- 230000007774 longterm Effects 0.000 description 9
- 230000005284 excitation Effects 0.000 description 8
- 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 description 7
- 102100024304 Protachykinin-1 Human genes 0.000 description 7
- 238000009795 derivation Methods 0.000 description 5
- 230000006866 deterioration Effects 0.000 description 5
- 101000655188 Homo sapiens Tachykinin-3 Proteins 0.000 description 3
- 101100243108 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDI1 gene Proteins 0.000 description 3
- 102100033009 Tachykinin-3 Human genes 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001917 fluorescence detection Methods 0.000 description 2
- 238000002189 fluorescence spectrum Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F10/00—Apparatus for measuring unknown time intervals by electric means
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F10/00—Apparatus for measuring unknown time intervals by electric means
- G04F10/005—Time-to-digital converters [TDC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F10/00—Apparatus for measuring unknown time intervals by electric means
- G04F10/10—Apparatus for measuring unknown time intervals by electric means by measuring electric or magnetic quantities changing in proportion to time
- G04F10/105—Apparatus for measuring unknown time intervals by electric means by measuring electric or magnetic quantities changing in proportion to time with conversion of the time-intervals
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F13/00—Apparatus for measuring unknown time intervals by means not provided for in groups G04F5/00 - G04F10/00
- G04F13/02—Apparatus for measuring unknown time intervals by means not provided for in groups G04F5/00 - G04F10/00 using optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
- G01N2021/6415—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence with two excitations, e.g. strong pump/probe flash
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/123—Conversion circuit
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measurement Of Unknown Time Intervals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-133839 | 2020-08-06 | ||
| JP2020133839 | 2020-08-06 | ||
| PCT/JP2021/018263 WO2022030062A1 (ja) | 2020-08-06 | 2021-05-13 | 時間計測装置、蛍光寿命計測装置、及び時間計測方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115803689A true CN115803689A (zh) | 2023-03-14 |
Family
ID=77915227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180046560.9A Pending CN115803689A (zh) | 2020-08-06 | 2021-05-13 | 时间测量装置、荧光寿命测量装置及时间测量方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230288336A1 (enrdf_load_stackoverflow) |
| EP (1) | EP4170436A4 (enrdf_load_stackoverflow) |
| JP (2) | JP6946599B1 (enrdf_load_stackoverflow) |
| KR (1) | KR20230047328A (enrdf_load_stackoverflow) |
| CN (1) | CN115803689A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025004353A1 (ja) * | 2023-06-30 | 2025-01-02 | 日本電信電話株式会社 | 測定装置、測定方法、及びプログラム |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6690463B2 (en) | 2000-02-10 | 2004-02-10 | Evotec Biosystems Ag | Fluorescence intensity and lifetime distribution analysis |
| DE102007026684B4 (de) * | 2007-06-08 | 2009-03-19 | Gesellschaft für Schwerionenforschung mbH | Zeit-Amplituden-Konverter-Bauelement |
| EP2199830B1 (en) | 2008-12-19 | 2014-07-02 | Leibniz-Institut für Neurobiologie | A position resolved measurement apparatus and a method for acquiring space coordinates of a quantum beam incident thereon |
| CN201926878U (zh) * | 2010-12-23 | 2011-08-10 | 中国科学院西安光学精密机械研究所 | 一种光子序列到达时间的连续测量装置 |
| US10079608B2 (en) * | 2011-09-08 | 2018-09-18 | Fastree 3D Bv | Time-to-digital converter and method therefor |
| US10520434B2 (en) | 2016-05-25 | 2019-12-31 | Leica Microsystems Cms Gmbh | Fluorescence lifetime imaging microscopy method having time-correlated single-photon counting, which method permits higher light intensities |
-
2021
- 2021-05-13 EP EP21853056.6A patent/EP4170436A4/en active Pending
- 2021-05-13 CN CN202180046560.9A patent/CN115803689A/zh active Pending
- 2021-05-13 KR KR1020227044160A patent/KR20230047328A/ko not_active Withdrawn
- 2021-05-13 JP JP2021541093A patent/JP6946599B1/ja active Active
- 2021-05-13 US US18/017,698 patent/US20230288336A1/en not_active Abandoned
- 2021-09-15 JP JP2021150175A patent/JP7660049B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230047328A (ko) | 2023-04-07 |
| JP6946599B1 (ja) | 2021-10-06 |
| JP7660049B2 (ja) | 2025-04-10 |
| JPWO2022030062A1 (enrdf_load_stackoverflow) | 2022-02-10 |
| US20230288336A1 (en) | 2023-09-14 |
| EP4170436A4 (en) | 2024-07-10 |
| JP2022031264A (ja) | 2022-02-18 |
| EP4170436A1 (en) | 2023-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |