CN115803689A - 时间测量装置、荧光寿命测量装置及时间测量方法 - Google Patents

时间测量装置、荧光寿命测量装置及时间测量方法 Download PDF

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Publication number
CN115803689A
CN115803689A CN202180046560.9A CN202180046560A CN115803689A CN 115803689 A CN115803689 A CN 115803689A CN 202180046560 A CN202180046560 A CN 202180046560A CN 115803689 A CN115803689 A CN 115803689A
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CN
China
Prior art keywords
time
signal
measurement
tac
detection signal
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Pending
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CN202180046560.9A
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English (en)
Chinese (zh)
Inventor
新仓史智
吉见步
北泽健
井上贵之
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Hamamatsu Photonics KK
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Hamamatsu Photonics KK
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Publication date
Application filed by Hamamatsu Photonics KK filed Critical Hamamatsu Photonics KK
Priority claimed from PCT/JP2021/018263 external-priority patent/WO2022030062A1/ja
Publication of CN115803689A publication Critical patent/CN115803689A/zh
Pending legal-status Critical Current

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    • GPHYSICS
    • G04HOROLOGY
    • G04FTIME-INTERVAL MEASURING
    • G04F10/00Apparatus for measuring unknown time intervals by electric means
    • GPHYSICS
    • G04HOROLOGY
    • G04FTIME-INTERVAL MEASURING
    • G04F10/00Apparatus for measuring unknown time intervals by electric means
    • G04F10/005Time-to-digital converters [TDC]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G04HOROLOGY
    • G04FTIME-INTERVAL MEASURING
    • G04F10/00Apparatus for measuring unknown time intervals by electric means
    • G04F10/10Apparatus for measuring unknown time intervals by electric means by measuring electric or magnetic quantities changing in proportion to time
    • G04F10/105Apparatus for measuring unknown time intervals by electric means by measuring electric or magnetic quantities changing in proportion to time with conversion of the time-intervals
    • GPHYSICS
    • G04HOROLOGY
    • G04FTIME-INTERVAL MEASURING
    • G04F13/00Apparatus for measuring unknown time intervals by means not provided for in groups G04F5/00 - G04F10/00
    • G04F13/02Apparatus for measuring unknown time intervals by means not provided for in groups G04F5/00 - G04F10/00 using optical means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G01N2021/6415Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence with two excitations, e.g. strong pump/probe flash
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/123Conversion circuit

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of Unknown Time Intervals (AREA)
CN202180046560.9A 2020-08-06 2021-05-13 时间测量装置、荧光寿命测量装置及时间测量方法 Pending CN115803689A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-133839 2020-08-06
JP2020133839 2020-08-06
PCT/JP2021/018263 WO2022030062A1 (ja) 2020-08-06 2021-05-13 時間計測装置、蛍光寿命計測装置、及び時間計測方法

Publications (1)

Publication Number Publication Date
CN115803689A true CN115803689A (zh) 2023-03-14

Family

ID=77915227

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180046560.9A Pending CN115803689A (zh) 2020-08-06 2021-05-13 时间测量装置、荧光寿命测量装置及时间测量方法

Country Status (5)

Country Link
US (1) US20230288336A1 (enrdf_load_stackoverflow)
EP (1) EP4170436A4 (enrdf_load_stackoverflow)
JP (2) JP6946599B1 (enrdf_load_stackoverflow)
KR (1) KR20230047328A (enrdf_load_stackoverflow)
CN (1) CN115803689A (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025004353A1 (ja) * 2023-06-30 2025-01-02 日本電信電話株式会社 測定装置、測定方法、及びプログラム

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6690463B2 (en) 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
DE102007026684B4 (de) * 2007-06-08 2009-03-19 Gesellschaft für Schwerionenforschung mbH Zeit-Amplituden-Konverter-Bauelement
EP2199830B1 (en) 2008-12-19 2014-07-02 Leibniz-Institut für Neurobiologie A position resolved measurement apparatus and a method for acquiring space coordinates of a quantum beam incident thereon
CN201926878U (zh) * 2010-12-23 2011-08-10 中国科学院西安光学精密机械研究所 一种光子序列到达时间的连续测量装置
US10079608B2 (en) * 2011-09-08 2018-09-18 Fastree 3D Bv Time-to-digital converter and method therefor
US10520434B2 (en) 2016-05-25 2019-12-31 Leica Microsystems Cms Gmbh Fluorescence lifetime imaging microscopy method having time-correlated single-photon counting, which method permits higher light intensities

Also Published As

Publication number Publication date
KR20230047328A (ko) 2023-04-07
JP6946599B1 (ja) 2021-10-06
JP7660049B2 (ja) 2025-04-10
JPWO2022030062A1 (enrdf_load_stackoverflow) 2022-02-10
US20230288336A1 (en) 2023-09-14
EP4170436A4 (en) 2024-07-10
JP2022031264A (ja) 2022-02-18
EP4170436A1 (en) 2023-04-26

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