CN115803000A - Cosmetic composition with stabilized retinol - Google Patents

Abstract

A cosmetic composition comprising about 0.01-3% by weight retinol; from about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate; about 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate; about 0.5 to about 7 weight percent polyglycerol-3 methyl glucose distearate; about 0.9 to about 7 weight percent sodium polyacrylate; about 0.5 to about 8 weight percent of an oil phase; and water, wherein all weight percents are based on the total weight of the cosmetic composition. In addition, cosmetic compositions are typically formulated to form oil-in-water emulsions. Also disclosed herein are methods of treating damaged skin with a cosmetic composition.

Description

Cosmetic composition with stabilized retinol

Cross Reference to Related Applications

The present application claims priority from U.S. application Ser. No.16/916,496, filed on 30/6/2020 and French patent application No.2009032, filed on 7/9/2020, which are incorporated herein by reference in their entirety.

FIELD OF THE DISCLOSURE

The present disclosure relates to cosmetic compositions having stabilized retinol. In addition, the disclosed aspects relate to methods for treating damaged skin using cosmetic compositions.

BACKGROUND OF THE DISCLOSURE

The skin acts as a natural barrier between the internal and external environment and therefore plays an important role in vital biological functions, such as protection against mechanical and chemical damage, microorganisms and ultraviolet light. However, the health and appearance of skin can deteriorate due to environmental factors, genetic makeup, nutrition, and eye exposure.

Environmental pollution conditions rapidly deteriorate and become more apparent in the daily lives of consumers all over the world. The damage of human skin by pollution is also becoming more and more evident. Human skin is also affected by various external factors, such as Ultraviolet (UV) radiation, environmental pollution, wind, heat, infrared radiation, low humidity, harsh surfactants, abrasion, and the like. Recent studies have shown that in addition to UV radiation, other environmental factors (especially air pollution) can also lead to the development of phototropic freckles. Ultimately, these factors lead to visible signs of skin damage, including small brown spots on the skin, especially in the elderly.

Typical skin lesions include fine lines, wrinkles, hyperpigmentation, sallowness, sagging, dark under-eye circles, puffy eyes, enlarged pores, visible dead skin, i.e., desquamation (flaking), peeling, dryness, and roughness. Consumers desire to slow the increase in skin damage and reduce the effects of aging, especially on the face and around the eyes. Shiny and clear skin appears youthful and is a sign of good health and vitality. Thus, there is a continuing need for new and improved formulations that improve skin health and visual appearance.

BRIEF SUMMARY OF THE PRESENT DISCLOSURE

The present disclosure relates to cosmetic compositions having stable retinol, and in particular to cosmetic compositions that provide improved penetration of such retinol into adult skin. The inventors have found that certain ingredients in specific amounts make it possible to have a cosmetic composition with stabilized retinol incorporated therein, such that the cosmetic composition may be contained in a non-protective package.

Cosmetic compositions according to one aspect of the present disclosure generally comprise:

(a) About 0.01 to about 3 weight percent retinol;

(b) From about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate;

(c) About 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate;

(d) About 0.5 to about 7 weight percent polyglycerol-3 methyl glucose distearate;

(e) About 0.9 to about 7 weight percent sodium polyacrylate;

(f) About 0.5 to about 8 weight percent of an oil phase; and

(g) The amount of water is controlled by the amount of water,

wherein the cosmetic composition is an oil-in-water emulsion and all weight percents are based on the total weight of the cosmetic composition.

In some cases, the cosmetic composition is formulated to have a weight ratio of the total amount of trisodium ethylenediamine disuccinate to the total amount of sodium polyacrylate of from about 1:1 to about 1: 2, from about 1:1 to about 1: 3, from about 1:1 to about 1: 4, from about 1:1 to about 1: 5; about 1: 1.5 to about 1: 3, about 1: 1.5 to about 1: 4, about 1: 1.5 to about 1: 5; about 1: 2 to about 1: 3, about 1: 2 to about 1: 4, about 1: 2 to about 1: 5; about 1: 2.5 to about 1: 4, about 1: 2.5 to about 1: 5; from about 1: 3 to about 1: 4, from about 1: 3 to about 1: 5.

The cosmetic composition may comprise an oil phase comprising silicone. The oil phase may additionally or alternatively comprise coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina sativa oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio nut oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil or mixtures thereof. In some cases, the oil phase may comprise fatty esters other than polyglycerol-3 methyl glucose distearate, such as those selected from isononyl isononanoate, caprylic/capric triglyceride, and mixtures thereof.

The cosmetic composition may comprise from about 0.05 to about 5 weight percent of a thickening agent that is not sodium polyacrylate. Thickeners other than sodium polyacrylate can be selected from the group consisting of ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymers, sodium polyacrylate, acrylate copolymers, polyacrylamides, carbomers, acrylate/C10-30 alkyl acrylate crosspolymer, acrylate/beheneth-25 methacrylate copolymer, and mixtures thereof.

In some cases, the cosmetic composition comprises from about 0.1 to about 10 weight percent matting agent. Preferably, the matting agent comprises aluminium starch octenyl succinate.

Additionally or alternatively, the cosmetic composition comprises from about 1 to about 30 weight percent of the polyol. Non-limiting examples of polyols include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, octylene glycol, 1, 3-propanediol, glycerol, diglycerol, polyethylene glycol, or mixtures thereof.

The cosmetic composition may comprise from about 0.05 to about 5% by weight of a skin active agent. Examples of skin active agents include, for example, hyaluronic acid, niacinamide, lanolin, retinoids, retinal, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, or mixtures thereof.

In some cases, the cosmetic composition is free of tocopherol. Additionally or alternatively, the cosmetic composition may be free of ascorbyl palmitate.

Detailed description of the disclosure

The present disclosure relates to cosmetic compositions with stabilized retinol, which provide improved penetration of retinol into adult skin. As mentioned above, the inventors have found that certain ingredients in specific amounts make it possible to have a cosmetic composition with stable retinol incorporated therein, such that the cosmetic composition may be contained in a non-protective package. For example, the cosmetic composition can stabilize retinol such that the cosmetic composition does not exhibit phase separation and retains at least 75% by weight retinol after 8 weeks of storage at 45 ℃ in a light-resistant glass container.

Surprisingly, in addition to stabilization of retinol, the cosmetic composition provides in some cases improved penetration of retinol into adult skin. Generally, cosmetic compositions that attempt to provide stabilized retinol utilize a large amount of an oil phase in which the retinol is dissolved. The penetration enhancer may be included in a cosmetic composition having a plurality of oil phases in which retinol is dissolved to eliminate the decrease in retinol penetration due to the plurality of oil phases. The present inventors have discovered that certain embodiments of cosmetic compositions stabilize retinol while providing improved penetration of retinol into adult skin.

According to one aspect of the present disclosure, there is provided a cosmetic composition generally comprising:

(a) About 0.01 to about 3 weight percent retinol;

(b) From about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate;

(c) About 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate;

(d) About 0.5 to about 7 weight percent polyglycerol-3 methyl glucose distearate;

(e) About 0.9 to about 7 weight percent sodium polyacrylate;

(f) About 0.5 to about 8 weight percent of an oil phase; and

(g) The amount of water is controlled by the amount of water,

wherein the cosmetic composition is an oil-in-water emulsion and all weight percents are based on the total weight of the cosmetic composition.

Preferably, the cosmetic composition does not phase separate and retains about 80% or more, about 82% or more, about 84% or more, about 86% or more, about 88% or more, about 90% or more, about 92% or more, about 94% or more, about 96% or more, 98% or more, about 99% or more, or about 99.5% or more by weight retinol after storage in a light-resistant glass container at 45 ℃ for 8 weeks. The inventors have surprisingly found that for certain embodiments of the cosmetic composition, 100% by weight of retinol is retained and shows no phase separation after 8 weeks of storage at 45 ℃ in a light-resistant glass container. In some cases, the cosmetic composition exhibits no phase separation and retains about 80% or more by weight retinol after 8 weeks of storage at 45 ℃ in a light-resistant glass container, with about 5% or less by weight, e.g., about 4% or less by weight, about 3% or less by weight, about 2% or less by weight, about 1% or less by weight, about 5000ppm or less, about 1000ppm or less, about 900ppm or less, about 800ppm or less, about 700ppm or less, about 600ppm or less, about 500ppm or less, about 400ppm or less, about 300ppm or less, about 200ppm or less, about 100ppm or less, about 50ppm or less of oxygen in the container. In further instances, the cosmetic composition exhibits no phase separation and retains about 80% or more by weight retinol after storage in light-resistant glass at 45 ℃ for 8 weeks, and the cosmetic composition has 1000ppm or less of oxygen, e.g., about 900ppm or less, about 800ppm or less, about 700ppm or less, about 600ppm or less, about 500ppm or less, about 400ppm or less, about 300ppm or less, about 200ppm or less, about 100ppm or less, about 50ppm or less of oxygen.

In some cases, the cosmetic composition achieves improved penetration of the skin active agent into adult skin. For example, cosmetic compositions can achieve penetration of a skin active agent (e.g., retinol) into the epidermis and dermis of the skin. In some cases, the cosmetic composition may achieve about 2 μ g/cm in the epidermis and dermis of human skin ² Or more, 2.1. Mu.g/cm ² Or more, 2.2. Mu.g/cm ² Or more, 2.3. Mu.g/cm ² Or more, 2.4. Mu.g/cm ² Or more, 2.5. Mu.g/cm ² Or more, 2.6. Mu.g/cm ² Or more, 2.7. Mu.g/cm ² Or more, 2.8. Mu.g/cm ² Or more, 2.9. Mu.g/cm ² Or more, 3. Mu.g/cm ² Or more skin active agents (e.g., retinol). In certain embodiments, the cosmetic composition achieves improved penetration of the skin active agent without the use of a penetration enhancer.

Some nutraceutical or cosmetic compositions achieve epidermal penetration through the use of skin penetration enhancing carriers or excipients. Such carriers or excipients (which are compounds or mixtures of compounds) are often described as "penetration enhancers" or "skin enhancers. Typical penetration enhancers, which may optionally be excluded from the cosmetic composition, include sulfoxides (e.g., dimethyl sulfoxide, DMSO), azones (e.g., laurocapram), pyrrolidones (e.g., 2-pyrrolidone, 2P), alcohols and alkanols (ethanol or decanol), surfactants (also commonly used dosage forms), and terpenes. Some penetration enhancers can be inserted between the hydrophobic tails of the bilayer, thereby interfering with their packing, increasing their fluidity, and subsequently causing the lipid-like penetrant to diffuse more easily. The present inventors have surprisingly found that certain cosmetic compositions according to the present disclosure provide improved penetration of retinol and/or other skin active agents into adult skin without the use of certain penetration enhancers.

In some cases, the cosmetic composition has 5% by weight or less, 4% by weight or less, 3% by weight or less, 2% by weight or less, or 1% by weight or less of any of the foregoing penetration enhancers. In at least one instance, the cosmetic composition is free or substantially free of any of the aforementioned penetration enhancers. Additionally or alternatively, the cosmetic composition may have a total amount of penetration enhancer of about 5 wt% or less, 4 wt% or less, 3 wt% or less, 2 wt% or less, or 1 wt% or less. For example, the cosmetic composition may be free or substantially free of penetration enhancers.

In some cases, the cosmetic composition may have 5% or less, 4% or less, 3% or less, 2% or less, or 1% or less by weight tocopherol. In at least one instance, the cosmetic composition is free or substantially free of tocopherol. The cosmetic composition may have 5% or less by weight, 4% or less by weight, 3% or less by weight, 2% or less by weight, or 1% or less by weight ascorbyl palmitate. In at least one instance, the cosmetic composition is free or substantially free of ascorbyl palmitate.

Cosmetic compositions are typically formulated as emulsions. Typically, cosmetic compositions are formulated as oil-in-water emulsions, in which a fatty phase is emulsified in a hydrophilic phase. However, in some cases, cosmetic compositions may be formulated to have a hydrophilic phase (e.g., alcohols, glycols, polyols, etc.) emulsified in a fatty phase. The cosmetic composition may be formulated as a lotion, essence, cream, spray, or any other suitable form of product.

The cosmetic composition may be packaged in a container containing the pump. In some cases, the pump may be a standard push pump. Preferably, the container for the cosmetic composition is a non-protective package. For example, in some cases, the cosmetic composition is contained in a container that does not include an aluminum layer or another metal layer that acts as an oxygen barrier.

In addition, the present disclosure relates to methods of treating skin comprising applying the cosmetic compositions of the present disclosure to the skin. Cosmetic compositions may also be used in methods of treating and/or repairing skin damage due to photoaging, and reducing the appearance of wrinkles, dark spots, and uneven skin texture. The above method may be non-therapeutic.

Suitable components, such as those listed below, may be included in or excluded from the formulation of the cosmetic composition, depending on the particular combination of other components, the form of the cosmetic composition, and/or the use of the formulation (e.g., lotion, essence, gel, cream, spray, etc.).

Retinol

The cosmetic composition comprises retinol, typically in an amount of from about 0.01 to about 3% by weight, based on the total weight of the cosmetic composition. For example, retinol may be present in the cosmetic composition in an amount of from about 0.01 to about 3 wt%, from about 0.01 to about 2.5 wt%, from about 0.01 to about 2 wt%, from about 0.01 to about 1.5 wt%, from about 0.01 to about 1 wt%, from about 0.01 to about 0.75 wt%, from about 0.01 to about 0.5 wt%; about 0.05 to about 3 wt%, about 0.05 to about 2.5 wt%, about 0.05 to about 2 wt%, about 0.05 to about 1.5 wt%, about 0.05 to about 1 wt%, about 0.05 to about 0.75 wt%, about 0.05 to about 0.5 wt%; about 0.1 to about 3 wt%, about 0.1 to about 2.5 wt%, about 0.1 to about 2 wt%, about 0.1 to about 1.5 wt%, about 0.1 to about 1 wt%, about 0.1 to about 0.75 wt%, about 0.1 to about 0.5 wt%; about 0.15 to about 3 wt%, about 0.15 to about 2.5 wt%, about 0.15 to about 2 wt%, about 0.15 to about 1.5 wt%, about 0.15 to about 1 wt%, about 0.15 to about 0.75 wt%, about 0.15 to about 0.5 wt%; from about 0.25 to about 3 wt%, from about 0.25 to about 2.5 wt%, from about 0.25 to about 2 wt%, from about 0.25 to about 1.5 wt%, from about 0.25 to about 1 wt%, from about 0.25 to about 0.75 wt%, from about 0.25 to about 0.5 wt%, based on the total weight of the cosmetic composition.

In addition to retinol, the cosmetic composition may optionally comprise a retinoid, such as those selected from retinoic acid, retinyl esters and other retinol derivatives. The amount of retinoid other than retinol present in the cosmetic composition can be, for example, from about 0.01 to about 3 wt%, from about 0.01 to about 2.5 wt%, from about 0.01 to about 2 wt%, from about 0.01 to about 1.5 wt%, from about 0.01 to about 1 wt%, from about 0.01 to about 0.75 wt%, from about 0.01 to about 0.5 wt%; about 0.05 to about 3 wt.%, about 0.05 to about 2.5 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1.5 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.75 wt.%, about 0.05 to about 0.5 wt.%; about 0.1 to about 3 wt%, about 0.1 to about 2.5 wt%, about 0.1 to about 2 wt%, about 0.1 to about 1.5 wt%, about 0.1 to about 1 wt%, about 0.1 to about 0.75 wt%, about 0.1 to about 0.5 wt%; about 0.15 to about 3 wt%, about 0.15 to about 2.5 wt%, about 0.15 to about 2 wt%, about 0.15 to about 1.5 wt%, about 0.15 to about 1 wt%, about 0.15 to about 0.75 wt%, about 0.15 to about 0.5 wt%; about 0.25 to about 3 wt.%, about 0.25 to about 2.5 wt.%, about 0.25 to about 2 wt.%, about 0.25 to about 1.5 wt.%, about 0.25 to about 1 wt.%, about 0.25 to about 0.75 wt.%, about 0.25 to about 0.5 wt.%, based on the total weight of the cosmetic composition.

Tetra-di-tert-butyl hydroxyhydrocinnamate

The cosmetic composition comprises tetra-di-tert-butyl hydroxyhydrocinnamate, typically in an amount of from about 0.01 to about 1% by weight, based on the total weight of the cosmetic composition. In some cases, the amount of tetra-di-tert-butyl hydroxyhydrocinnamate present in the cosmetic composition can be from about 0.01 to about 1 wt%, from about 0.01 to about 0.8 wt%, from about 0.01 to about 0.6 wt%, from about 0.01 to about 0.4 wt%, from about 0.01 to about 0.2 wt%; about 0.05 to about 1 wt%, about 0.05 to about 0.8 wt%, about 0.05 to about 0.6 wt%, about 0.05 to about 0.4 wt%, about 0.05 to about 0.2 wt%; about 0.1 to about 1 wt%, about 0.1 to about 0.8 wt%, about 0.1 to about 0.6 wt%, about 0.1 to about 0.4 wt%, about 0.1 to about 0.2 wt%; about 0.15 to about 1 wt%, about 0.15 to about 0.8 wt%, about 0.15 to about 0.6 wt%, about 0.15 to about 0.4 wt%; from about 0.2 to about 1 wt%, from about 0.2 to about 0.8 wt%, from about 0.2 to about 0.6 wt%, from about 0.2 to about 0.4 wt%, from about 0.2 to about 0.2 wt%, inclusive of ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Ethylene diamine disuccinic acid trisodium salt

The cosmetic composition comprises trisodium ethylenediamine disuccinate, typically in an amount of from about 0.01 to about 3 wt%, based on the total weight of the cosmetic composition. In some cases, trisodium ethylenediamine disuccinate may be present in the cosmetic composition in an amount of from about 0.01 to about 3 wt.%, from about 0.01 to about 2.5 wt.%, from about 0.01 to about 2 wt.%, from about 0.01 to about 1.5 wt.%, from about 0.01 to about 1 wt.%, from about 0.01 to about 0.8 wt.%, from about 0.01 to about 0.6 wt.%, from about 0.01 to about 0.4 wt.%, from about 0.01 to about 0.2 wt.%, from about 0.01 to about 0.1 wt.%; 0.05 to about 3 wt%, about 0.05 to about 2.5 wt%, about 0.05 to about 2 wt%, about 0.05 to about 1.5 wt%, about 0.05 to about 1 wt%, about 0.05 to about 0.8 wt%, about 0.05 to about 0.6 wt%, about 0.05 to about 0.4 wt%, about 0.05 to about 0.2 wt%, about 0.05 to about 0.1 wt%; 0.1 to about 3 wt%, about 0.1 to about 2.5 wt%, about 0.1 to about 2 wt%, about 0.1 to about 1.5 wt%, about 0.1 to about 1 wt%, about 0.1 to about 0.8 wt%, about 0.1 to about 0.6 wt%, about 0.1 to about 0.4 wt%, about 0.1 to about 0.2 wt%; 0.15 to about 3 wt%, about 0.15 to about 2.5 wt%, about 0.15 to about 2 wt%, about 0.15 to about 1.5 wt%, about 0.15 to about 1 wt%, about 0.15 to about 0.8 wt%, about 0.15 to about 0.6 wt%, about 0.15 to about 0.4 wt%; 0.2 to about 3 wt.%, about 0.2 to about 2.5 wt.%, about 0.2 to about 2 wt.%, about 0.2 to about 1.5 wt.%, about 0.2 to about 1 wt.%, about 0.2 to about 0.8 wt.%, or about 0.2 to about 0.6 wt.%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Polyglyceryl-3 methyl glucose distearate

The cosmetic composition comprises polyglycerol-3 methyl glucose distearate, which amount may vary, but is typically present in an amount of from about 0.5 to about 7 weight percent based on the total weight of the cosmetic composition. In some cases, the amount of polyglycerol-3 methylglucose distearate in the cosmetic composition is from about 0.5 to about 7 wt.%, from about 0.5 to about 6 wt.%, from about 0.5 to about 5 wt.%, from about 0.5 to about 4 wt.%, from about 0.5 to about 3 wt.%, from about 0.5 to about 2 wt.%, from about 0.5 to about 1 wt.%; about 0.75 to about 7 wt.%, about 0.75 to about 6 wt.%, about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%; about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, or about 1 to about 2 wt.%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

One or more sodium polyacrylates

The cosmetic composition comprises sodium polyacrylate, typically in an amount of about 0.9 to about 7 weight percent, based on the total weight of the cosmetic composition. For example, sodium polyacrylate can be present in the cosmetic composition in an amount of about 0.9 to about 7 wt.%, about 0.9 to about 6 wt.%, about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%, about 0.9 to about 1.5 wt.%; about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, or about 1 to about 2 wt.%; about 1.25 to about 7 wt.%, about 1.25 to about 6 wt.%, about 1.25 to about 5 wt.%, about 1.25 to about 4 wt.%, about 1.25 to about 3 wt.%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Generally, sodium polyacrylate can be present in the composition in particulate or non-particulate form. When the sodium polyacrylate is present in particulate form, its average size in the hydrated state is preferably less than or equal to 10 μm, and even more preferably less than or equal to 5 μm. Their average size in the non-hydrated state is preferably less than or equal to 2 μm, preferably less than or equal to 1 μm.

Non-limiting examples of commercially available sodium polyacrylates include those sold by Avecia under the names Octacare X100, X110 and RM100, those sold by SNF under the names florcare GB300 and florsorb 500; BASF those sold under the names Luquasorb 1003, luquasorb 1010, luquasorb 1280, and Luquasorb 1100; those sold by Grain Processing under the names Water Lock G400 and G430 (INCI name: acrylamide/sodium acrylate copolymer); those sold under the names Aqua Keep 10SH NF, aqua Keep 10SH NFC, sodium acrylate crosspolymer-2, supplied by Sumitomo Seika; and/or those sold by Sanyo Chemical Industries under the names Sanfresh ST-100C, ST 100MC, and IM-300MC (INCI name: sodium polyacrylate starch).

One or more oils

The cosmetic composition includes an oil phase comprising one or more oils. The amount of oil phase (e.g., total amount of oil) is typically 0.5 to 8 wt%, based on the total weight of the cosmetic composition. The oil phase may comprise one or more oils, such as silicone oils, fluoro oils, hydrocarbon-based oils, and the like. In some cases, the cosmetic composition includes an oil that is vegetable-based or vegetable-based.

The amount of oil and/or vegetable-based oil present in the cosmetic composition may be from about 0.5 to about 8 wt%, from about 0.5 to about 7 wt%, from about 0.5 to about 6 wt%, from about 0.5 to about 5 wt%; about 1 to about 8 wt%, about 1 to about 7 wt%, about 1 to about 6 wt%, about 1 to about 5 wt%; about 2 to about 8 wt%, about 2 to about 7 wt%, about 2 to about 6 wt%, about 2 to about 5 wt%; about 3 to about 8 wt%, about 3 to about 7 wt%, about 3 to about 6 wt%, about 3 to about 5 wt%; about 4 to about 8 wt%, about 4 to about 7 wt%, about 4 to about 6 wt%; from about 5 to about 8 wt%, or from about 5 to about 7 wt%, including all ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Additionally and/or alternatively, the cosmetic composition may not comprise a synthetic oil. In some cases, the cosmetic composition may exclude oils other than plant-based and vegetable-based oils. For example, the amount of synthetic oil and/or oils other than plant-based and vegetable-based oils may be about 5 wt% or less, about 4 wt% or less, about 3 wt% or less, about 2 wt% or less, about 1 wt% or less, or about 0.5 wt% or less, based on the total weight of the cosmetic composition. In at least one embodiment, the cosmetic composition is free or substantially free of synthetic oils and/or oils other than plant-based and vegetable-based oils.

The cosmetic composition may comprise an oil phase comprising low O ₂ Oil-permeable (e.g., having 0.3% or less O) ₂ A penetrating oil); medium O ₂ Permeable to oil (e.g., with 0.3% to 0.4% O) ₂ A penetrating oil); and/or higher O ₂ Permeable oils (e.g. O) ₂ Oil with a permeability greater than 0.4%). In some cases, the cosmetic composition comprises about 50% or more by weight, about 60% or more by weight, about 70% or more by weight, about 80% or more by weight, about 85% or more by weight, or about 90% or more by weight low O ₂ The oil may be permeable based on the total weight of the oil and/or oil phase. The cosmetic composition may comprise about 50% by weight or less, about 40% by weight or moreA small, about 30 wt% or less, about 20 wt% or less, about 10 wt% or less, an amount of about 5 wt% or less of medium O ₂ Is permeable to oil. Additionally or alternatively, the cosmetic composition may comprise a higher O of about 30% by weight or less, about 20% by weight or less, about 10% by weight or less, about 5% by weight or less ₂ Is permeable to oil.

The term "oil" refers to any aliphatic substance that is in liquid form at room temperature (20-25 ℃) and atmospheric pressure (760 mmHg). An "oily phase" is a phase comprising at least one oil which may comprise further fat-soluble and lipophilic ingredients and fatty substances. Oils suitable for use herein may be volatile or non-volatile. The term "volatile oil" relates to an oil capable of evaporating in less than one hour on contact with the skin or keratin fibres, at room temperature and atmospheric pressure. The volatile oil(s) are liquid at room temperature and have a non-zero vapour pressure, in particular from 0.13Pa to 40000Pa (10 Pa) at room temperature and atmospheric pressure ^-3 -300 mmHg). The term "non-volatile oil" relates to an oil which remains on the skin or keratin fibres for at least several hours at room temperature and atmospheric pressure, and which in particular has a viscosity of less than 10 ^-3 Vapor pressure of mmHg (0.13 Pa).

The term "silicone oil" relates to an oil comprising at least one silicon atom, and in particular at least one Si-O group. The term "fluoro oil" relates to an oil comprising at least one fluorine atom. The term "hydrocarbon-based oil" relates to an oil comprising mainly hydrogen and carbon atoms. The hydrocarbon-based oil may be an animal hydrocarbon-based oil, a vegetable hydrocarbon-based oil, a mineral hydrocarbon-based oil, or a synthetic hydrocarbon-based oil. Further, suitable oils may be mineral hydrocarbon based oils, vegetable hydrocarbon based oils or synthetic hydrocarbon based oils.

Silicone oil

The cosmetic compositions described herein may comprise one or more silicone oils. Non-limiting examples of silicone oils include polydimethylsiloxane, cyclomethicone, polysiloxane-11, phenyl trimethicone, trimethylsilylamino terminated polydimethylsiloxane, and stearyloxytrimethylsilane. In some cases, the cosmetic composition comprises polydimethylsiloxane, and optionally additional oils, including additional silicone oils. Typically, the one or more silicone oils are non-volatile silicone oils. In some embodiments, the silicone oil is Polydimethylsiloxane (PDMS), a polydimethylsiloxane comprising alkyl or alkoxy groups that are pendant and/or at the ends of the polysiloxane chain, each containing 2 to 24 carbon atoms, or a phenyl polysiloxane, such as phenyl trimethicone, phenyl polydimethylsiloxane, phenyl (trimethylsiloxy) diphenylsiloxane, diphenyl polydimethylsiloxane, diphenyl (methyldiphenyl) trisiloxane, or (2-phenylethyl) trimethylsiloxysilicate.

Further examples of silicone oils which may be mentioned include volatile linear or cyclic silicone oils, in particular those having a viscosity of 8 centistokes (8X 10) ⁶ m ² /s) and in particular those containing from 2 to 7 silicon atoms, these silicone oils optionally comprising alkyl or alkoxy groups containing from 1 to 10 carbon atoms. Mention may in particular be made, as volatile silicone oils which can be used in the present invention, of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane and mixtures thereof.

Fluorine oil

The cosmetic compositions described herein may comprise one or more fluoro oils. For example, the one or more fluoro oils may be selected from perfluoromethylcyclopentane, perfluoro-1, 3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane and 4-trifluoromethylperfluoromorpholine. Volatile fluoro oils such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane may also be used.

Hydrocarbon-based oils

The cosmetic compositions described herein may comprise one or more hydrocarbon-based oils. For example, the hydrocarbon-based oil may be a saturated hydrocarbon, an unsaturated hydrocarbon, a lipid, a triglyceride, a natural oil, and/or a synthetic oil. In some embodiments, the composition comprises a synthetic oil selected from the group consisting of hydrogenated polyisobutenes and hydrogenated polydecenes.

Hydrocarbon-based oils may be based on non-volatile hydrocarbons, such as:

(i) Hydrocarbon-based oils of vegetable origin, such as the triglycerides, which are generally triesters of fatty acids and glycerol, the fatty acids of which may have a C ₄ To C ₂₄ Of (a), which chains may be saturated or unsaturated and straight or branched; these oils are in particular wheat germ oil, sunflower oil, grape seed oil, sesame oil, corn oil, almond oil, castor oil, shea butter, avocado oil, olive oil, soybean oil, sweet almond oil, palm oil, rapeseed oil, cottonseed oil, hazelnut oil, macadamia nut oil, jojoba oil, alfalfa oil, poppy oil, pumpkin seed oil, marrow oil, blackcurrant oil, evening primrose oil, millet oil, barley oil, quinoa oil, rye oil, safflower oil, chinese gooseberry oil, passion flower oil and musk rose oil.

(ii) Synthetic ethers containing 10 to 40 carbon atoms;

(iii) Linear or branched hydrocarbons of mineral or synthetic origin, such as vaseline, polydecene, hydrogenated polyisobutenes, such as Parleam and 40 squalane;

(iv) Synthetic esters, for example oils of the formula RCOOR ', in which R denotes a straight-chain or branched fatty acid residue having from 1 to 40 carbon atoms and R ' denotes a, in particular branched, hydrocarbon-based chain having from 1 to 40 carbon atoms, with the proviso that R + R ' ≧ 10, for example, hundred-lol oil (cetearyl octanoate), isopropyl myristate, isopropyl palmitate, C-benzoic acid ₁₂ -C ₁₅ Alkyl esters, e.g. under the trade name Witco

Or

The product sold or under the trade name Evonik Goldschmidt

Products sold, 2-ethylphenyl benzoate, for example the commercial product sold under the name X-Tend 226 by ISP, isopropyl lanolate, hexyl laurate, diisopropyl adipateEsters, isononyl isononanoate, erucyl acid, 2-ethylhexyl palmitate, isostearyl isostearate, diisopropyl sebacate, such as the product sold under the name "Dub Dis" by Stearinerie Dubois, octanoates, silicates or ricinoleates of alcohols or polyols, such as propylene glycol dicaprylate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartrates, e.g. di (straight chain C) ₁₂ -C ₁₃ Alkyl) tartrates, e.g. Enichem Augusta Industriale under the name Cosmacol

Those sold, and di (straight chain C) ₁₄ -C ₁₅ Alkyl) tartrates, e.g. under the name cosmecol by the same company

Those sold; or an acetate ester;

(v) Fatty alcohols which are liquid at room temperature and contain branched and/or unsaturated carbon-based chains having from 12 to 26 carbon atoms, such as octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-hexyldecanol, 2-butyloctanol or 2-undecylpentadecanol;

(vi) Higher fatty acids, such as oleic acid, linoleic acid or linolenic acid;

(vii) Carbonates, e.g. dioctyl carbonate, e.g. Cognis under the name

The product being sold;

(viii) Fatty amides, e.g. isopropyl N-lauroyl sarcosinate, e.g. Ajinomoto under the trade name Ajinomoto

The product being sold; and

(ix) The essential oil is selected from sunflower oil, sesame oil, peppermint oil, macadamia nut oil, tea tree oil, evening primrose oil, sage oil, rosemary oil, coriander oil, thyme oil, pimento oil, rose oil, fennel oil, allspice oil (pimento berries oil), rose oil, cedar oil, peru balsam oil, bergamot oil, rosewood oil, cedar oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea anise oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, orange oil, patchouli oil, pepper oil, black pepper oil, orange leaf oil, pine oil, rose oil, rosemary oil, sandalwood oil, spearmint oil, wintergreen oil, and evergreen oil.

In some cases, the non-volatile hydrocarbon-based oil is a triglyceride, and in particular caprylic/capric triglyceride, a synthetic ester, and in particular isononyl isononanoate, erucic acid oil ester, benzoic acid C ₁₂ -C ₁₅ Alkyl esters, 2-ethylphenyl benzoate and fatty alcohols, for example octyldodecanol.

As volatile hydrocarbon-based oils, mention may be made of hydrocarbon-based oils containing from 8 to 16 carbon atoms, and in particular branched C ₈ -C ₁₆ Alkanes, e.g. C of petroleum origin ₈ -C ₁₆ Isoalkanes (also known as isoparaffins), for example isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane or isohexadecane, oils sold under the trade name Isopar or Permethyl, branched C ₈ -C ₁₆ Esters and isohexyl pivalate.

Preferably, the oil is selected from vegetable-based or vegetable-based oils such as coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina sativa oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil, and mixtures thereof.

One or more fatty esters other than polyglycerol-3-methyl glucose distearate

The cosmetic composition may comprise one or more fatty esters other than polyglycerol-3 methyl glucose distearate. In some cases, the fatty esters are considered part of the oil phase. The one or more fatty esters other than polyglycerol-3-methyl glucose distearate may be a glycerol fatty acid ester, a sorbitan fatty acid ester, an ethoxylated fatty acid ester, a synthetic ester, or the like. A discussion of one or more fatty esters other than polyglycerol-3 methyl glucose distearate that may be included in a cosmetic composition is provided below.

Glycerin fatty acid ester

The glycerol fatty acid esters that can be used as nonionic amphiphilic lipids can be chosen in particular from esters formed from at least one acid comprising a saturated linear alkyl chain having from 16 to 22 carbon atoms and from 1 to 10 glycerol units. One or more of these glycerin fatty acid esters may be used in the emulsions of the present disclosure.

Sorbitan fatty acid ester

Sorbitan fatty acid esters which can be used as the non-ionic amphiphilic lipid are in particular selected from esters of C16-C22 fatty acids and esters of sorbitan and ethoxylated esters of C16-C22 fatty acids and sorbitan. They are formed from at least one fatty acid comprising at least one saturated linear alkyl chain having from 16 to 22 carbon atoms respectively and sorbitol or ethoxylated sorbitol. The oxyethylenated esters generally comprise from 1 to 100 ethylene oxide units, and preferably from 2 to 40 Ethylene Oxide (EO) units.

These esters may be chosen in particular from stearates, behenates, arachinates, palmitates and mixtures thereof. Preferably, stearates and palmitates are used.

As examples of sorbitan fatty acid esters and oxyethylenated sorbitan fatty acid esters, mention may be made of sorbitan monostearate sold under the name Span 60 by the company ICI (CTFA name: sorbitan stearate), sorbitan monopalmitate sold under the name Span 40 by the company ICI (CTFA name: sorbitan palmitate), or sorbitan 20 EO tristearate sold under the name Tween 65 by the company ICI (CTFA name: polysorbate 65).

Ethoxylated fatty acid esters

Ethoxylated fatty acid esters that can be used as the nonionic amphiphilic lipid are esters composed of 1 to 100 ethylene oxide units and at least one fatty acid chain containing 16 to 22 carbon atoms. The fatty chain of the ester may be chosen in particular from stearate, behenate, arachinate and palmitate units and mixtures thereof. As examples of ethoxylated fatty acid esters, mention may be made of stearates comprising 40 ethylene oxide units, such as the one sold under the name Myrj 52 (CTFA name: PEG-40 stearate) by ICI, and behenates comprising 8 ethylene oxide units (CTFA name: PEG-8 behenate), such as the one sold under the name Comritol HD5 ATO by Gattefosse.

Synthesis of esters

Synthetic esters, for example oils of the formula RCOOR ', in which R denotes a straight-chain or branched fatty acid residue having from 1 to 40 carbon atoms and R ' denotes a particularly branched hydrocarbon-based chain having from 1 to 40 carbon atoms, with the proviso that R + R '. Gtoreq.10, for example, against oil (cetearyl octanoate), isopropyl myristate, isopropyl palmitate, C12-C15-alkyl benzoates, for example Witco, under the trade name

Or

The product sold, or Evonik Goldschmidt under the trade name Evonik Goldschmidt

Products sold under the name X-Tend 226, 2-ethylphenyl benzoate, for example the commercial product sold under the name X-Tend 226 by ISP, isopropyl lanolate, hexyl laurate, diisopropyl adipate, isononyl isononanoate, erucyl ester, 2-ethylhexyl palmitate, isostearyl isostearate, diisopropyl sebacate, for example the product sold under the name "Dub Dis" by Stearinerie Dubois, caprylic esters of alcohols or polyolsSilicates or ricinoleates, such as propylene glycol dicaprylate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartrates, e.g. di (linear C12-C13 alkyl) tartrates, e.g. Enichem Augusta Industriale, by name

Those sold, and di (linear C14-C15 alkyl) tartrates, e.g. by the same company under the name

Those sold; or an acetate ester.

The fatty acid ester other than polyglyceryl-3 methyl glucose distearate may be present in the cosmetic composition in an amount of from about 0.5 to about 8 wt.%, from about 0.5 to about 7 wt.%, from about 0.5 to about 6 wt.%, from about 0.5 to about 5 wt.%; about 1 to about 8 wt%, about 1 to about 7 wt%, about 1 to about 6 wt%, about 1 to about 5 wt%; about 2 to about 8 wt%, about 2 to about 7 wt%, about 2 to about 6 wt%, about 2 to about 5 wt%; about 3 to about 8 wt%, about 3 to about 7 wt%, about 3 to about 6 wt%, about 3 to about 5 wt%; about 4 to about 8 wt%, about 4 to about 7 wt%, about 4 to about 6 wt%; from about 5 to about 8 wt%, or from about 5 to about 7 wt%, including all ranges and subranges therebetween, based on the total weight of the cosmetic composition.

One or more thickeners other than sodium polyacrylate

The cosmetic compositions described herein may optionally comprise a thickening agent other than sodium polyacrylate. The amount of thickener other than sodium polyacrylate can be about 0.05 wt% to about 5 wt%, about 0.05 wt% to about 4 wt%, about 0.05 wt% to about 3 wt%, about 0.05 wt% to about 2 wt%, about 0.05 wt% to about 1 wt%; about 0.1 wt% to about 5 wt%, about 0.1 wt% to about 4 wt%, about 0.1 wt% to about 3 wt%, about 0.1 wt% to about 2 wt%, about 0.1 wt% to about 1 wt%; about 0.2 wt% to about 5 wt%, about 0.2 wt% to about 4 wt%, about 0.2 wt% to about 3 wt%, about 0.2 wt% to about 2 wt%, about 0.2 wt% to about 1 wt%; from about 0.3 wt% to about 5 wt%, from about 0.3 wt% to about 4 wt%, from about 0.3 wt% to about 3 wt%, from about 0.3 wt% to about 2 wt%, or from about 0.3 wt% to about 1 wt%, including ranges and subranges thereof, based on the total weight of the cosmetic composition. Further, the amount of thickener can be from 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, or 1.5 wt% to 2,3, 4, or 5 wt%, including ranges and subranges thereof, based on the total weight of the cosmetic composition.

Many thickeners are water soluble and when the cosmetic compositions of the present invention are dispersed/dissolved in water, the thickeners increase the viscosity of the water or form an aqueous gel. The aqueous solution may be heated and cooled, if desired, or neutralized to form a gel. The thickener other than sodium polyacrylate may be dispersed/dissolved in an aqueous solvent (when the aqueous solvent is dispersed/dissolved in water) soluble in water, such as ethanol.

Thickeners may be referred to as "thickeners" or "viscosity modifiers". Thickeners are typically included to increase the viscosity of the composition. However, in some cases, certain thickeners provide additional, surprising benefits to the composition. Non-limiting examples of thickeners include polyacrylate cross-linked polymers (other than sodium polyacrylate) or cross-linked polyacrylate polymers (other than cross-linked sodium polyacrylate), cationic acrylate copolymers, anionic acrylic or carboxylic acid polymers, polyacrylamide polymers, polysaccharides such as cellulose derivatives, gums, polyquaterniums, vinyl pyrrolidone homopolymers/copolymers, C8-24 hydroxy substituted aliphatic acids, C8-24 conjugated aliphatic acids, sugar fatty acid esters, polyglycerol esters, and mixtures thereof. Suitable thickeners other than sodium polyacrylate can be found in U.S. patent application No. 16/731, 654, which is incorporated herein in its entirety for all purposes.

The thickener other than sodium polyacrylate can be selected from xanthan gum, guar gum, biosaccharide gum, cellulose, gum arabic, sclerotium rolfsii gum, agarose, pectin, gellan gum, hyaluronic acid. In addition, the thickener other than sodium polyacrylate may include a polymer thickener selected from the group consisting of polyacryloyldimethyl ammonium taurate, acryloyldimethyl ammonium taurate/VP copolymer, acrylate copolymer, polyacrylamide, carbomer, and acrylate/C10-30 alkyl acrylate crosspolymer.

Specific types of thickeners that may be mentioned include the following:

homopolymers or copolymers based on carboxylic acids or carboxylic acid esters/salts, which may be linear or crosslinked:

these polymers contain one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids (acrylates) and substituted acrylic acids. Commercially available polymers include those sold under the tradenames CARBOPOL, ACRYSOL, POLYGEL, SOKALAN, CARBOPOL ULTREZ, and POLYGEL. Examples of commercially available carboxylic acid polymers include carbomers (carbomers), which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythritol. Carbomers are available as CARBOPOL 900 series (e.g., CARBOPOL 954) from b.f. goodrich. Additionally, other suitable carboxylic acid polymerization agents include ULTREZ 10 (B.F. Goodrich) and copolymers of C10-30 alkyl acrylates with one or more monomers that are acrylic acid, methacrylic acid, or one of its short chain (i.e., C1-4 alcohol) esters, where the crosslinking agent is an allyl ether of sucrose or pentaerythritol. These copolymers are known as acrylate/C10-C30 alkyl acrylate crosspolymers and are commercially available from B.F. Goodrich as CARBOPOL 1342, CARBOPOL 1382, PEMULEN TR-1 and PEMULEN TR-2.

Other suitable carboxylic acid or carboxylate ester/salt polymerization agents include copolymers of acrylic acid and C5-C10 alkyl acrylates (alkyl C5-C10 acrylates), copolymers of acrylic acid and maleic anhydride, and polyacrylate crosspolymer-6. Of the raw materials, polyacrylate crosspolymer-6 is available under the name SEPIMAX ZEN from Seppic.

Another suitable carboxylic acid or carboxylate polymeric reagent includes acrylamidopropyl trimethyl ammonium chloride/acrylate/salt copolymers, cationic acrylate/salt copolymers (or quaternary ammonium compounds) available from Seppic as a raw material known under the trade name SIMULQUAT HC 305.

In certain embodiments, the carboxylic acid or carboxylate polymer thickeners useful herein are selected from carbomers, acrylate/C10-C30 alkyl acrylate crosspolymers, polyacrylate crosspolymer-6, acrylamidopropyltrimethylammonium chloride/acrylate copolymers, and mixtures thereof.

Polyquaternary ammonium compounds

Non-limiting examples include polyquaternium-1, polyquaternium-2, polyquaternium-3, polyquaternium-4, polyquaternium-5, polyquaternium-6, polyquaternium-7, polyquaternium-8, polyquaternium-9, polyquaternium-10, polyquaternium-11, polyquaternium-12, polyquaternium-13, polyquaternium-14, polyquaternium-9, polyquaternium-4, polyquaternium-5, polyquaternium-9, polyquaternium-10 polyquaternium-15, polyquaternium-16, polyquaternium-17, polyquaternium-18, polyquaternium-19, polyquaternium-20, polyquaternium-21, polyquaternium-22, polyquaternium-23, polyquaternium-24, polyquaternium-25, polyquaternium-26, polyquaternium-27, polyquaternium-28, polyquaternium Polyquaternary ammonium salt-29, polyquaternary ammonium salt-30, polyquaternary ammonium salt-40, polyquaternary ammonium salt-41, polyquaternary ammonium salt-42, polyquaternary ammonium salt-43, polyquaternary ammonium salt-44, polyquaternary ammonium salt-45, polyquaternary ammonium salt-46, polyquaternary ammonium salt-47, polyquaternary ammonium salt-48, polyquaternary ammonium salt-49, polyquaternary ammonium salt-50, polyquaternary ammonium salt-51, polyquaternary ammonium salt-52, polyquaternary ammonium salt-53, polyquaternary ammonium salt-54, polyquaternary ammonium salt-55, polyquaternary ammonium salt-56, polyquaternary ammonium salt-57, polyquaternary ammonium salt-58, polyquaternary ammonium salt-59, polyquaternary ammonium salt-60, polyquaternary ammonium salt-61, polyquaternary ammonium salt-62, polyquaternary ammonium salt-63, polyquaternary ammonium salt-64, polyquaternary ammonium salt-65, polyquaternary ammonium salt-66, polyquaternary ammonium salt-65, polyquaternary ammonium salt-50, polyquaternary ammonium salt, polyquaternary ammonium salt-67, and the like. In some cases, preferred polyquaternium compounds include polyquaternium-10, polyquaternium-11, polyquaternium-67, and mixtures thereof. In some cases, the cosmetic composition comprises polyquaternium-10, polyquaternium-11, polyquaternium-67, or mixtures thereof.

Cellulose, process for producing the same, and process for producing the same

Non-limiting examples of cellulose include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. In some cases, the cellulose is selected from water-soluble cellulose derivatives (e.g., carboxymethyl cellulose, methyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium salts of cellulose sulfate). Further, in some cases, the cellulose is preferably hydroxypropyl cellulose (HPC). In some cases, the cosmetic composition comprises one or more cellulose thickeners (e.g., microcrystalline cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, and hydroxypropyl cellulose).

Polyvinylpyrrolidone (PVP) and copolymers

Non-limiting examples include polyvinylpyrrolidone (PVP), polyvinylpyrrolidone (PVP)/vinyl acetate copolymer (PVP/VA copolymer), polyvinylpyrrolidone (PVP)/eicosene copolymer, PVP/hexadecene copolymer, and the like. Commercially available polyvinylpyrrolidones include LUVISKOL K30, K85, K90 from BASF. Commercially available copolymers of vinyl pyrrolidone and vinyl acetate include LUVISKOL VA37, VA64 from BASF; copolymers of vinylpyrrolidone, methacrylamide and vinylimidazole (INCI: VP/methacrylamide/vinylimidazole copolymer) are commercially available as LUVISET from BASF. In some cases, PVP and PVP/VA copolymers are preferred.

Sucrose esters

Non-limiting examples include sucrose palmitate, sucrose cocoate, sucrose monocaprylate, sucrose monodecate, sucrose mono-or dilaurate, sucrose monomyristate, sucrose mono-or dipalmitate, sucrose mono-and distearate, sucrose mono-, di-or trioleate, sucrose mono-or dilinoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate or sucrose octaoleate, and mixed esters such as sucrose palmitate/stearate, and mixtures thereof.

Polyglycerol esters

Non-limiting polyglycerol esters (polyglycerol esters) of fatty acids include those of the formula:

wherein n is 2 to 20 or 2 to 10 or 2 to 5, or is 2,3, 4,5, 6, 7, 8, 9 or 10, and R ¹ 、R ² And R ³ Each independently can be a fatty acid moiety or hydrogen, provided that R ¹ 、R ² And R ³ At least one of which is a fatty acid moiety. For example, R ¹ 、R ² And R ³ May be saturated or unsaturated, linear or branched, and has a length C ₁ -C ₄₀ 、C ₁ -C ₃₀ 、C ₁ -C ₂₅ Or C ₁ -C ₂₀ 、C ₁ -C ₁₆ Or C ₁ -C ₁₀ . Additionally, non-limiting examples of nonionic polyglyceryl esters of fatty acids include polyglyceryl-4 caprylate/caprate, polyglyceryl-10 caprylate/caprate, polyglyceryl-4 caprate, polyglyceryl-10 caprate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, polyglyceryl-10 cocoate, polyglyceryl-10 myristate, polyglyceryl-10 oleate, polyglyceryl-10 stearate, and mixtures thereof.

C8-24 hydroxy-substituted aliphatic acids and C8-24 conjugated aliphatic acids

Non-limiting examples include conjugated linoleic acid, cis-stearidonic acid, trans-7-octadecenoic acid, cis-5,8, 11, 14, 17-eicosapentaenoic acid, cis-4,7, 10, 13, 16, 19-docosahexaenoic acid, colombinic acid, elaidic acid, ricinoleic acid (ricinolaidic acid), stearidonic acid, 2-hydroxystearic acid, alpha-linolenic acid, arachidonic acid, cis-11, 14-eicosadienoic acid, elaidic acid, monostearic-6-enoic acid (monoprotiselinic acid), petroselinic acid (petroselinic acid), ricinoleic acid (ricinoleic acid), trans-vaccenic acid, cis-11, 14, 17-eicosatrienoic acid, cis-5-eicosenoic acid, cis-8, 11, 14-eicosatrienoic acid, hexadecatrienoic acid, palmitoleic acid, trans-6-octadecenoic acid, trans-farnesol, cis-13, 16-docosadienoic acid, cis-vaccenic acid, cis-11-eicosenoic acid, cis-13, 16, 19-eicosatrienoic acid, cis-13-octadecenoic acid, cis-15-octadecanoic acid, cis-7, 10, 13, 16 docosatetraenoic acid, elaidic acid, gamma-linolenic acid, geranic acid, geranylgeranic acid (geranic acid), linoleic acid, oleic acid, pinolenic acid, trans-13-octadecenoic acid. More preferably, the aliphatic acid comprises 12-hydroxystearic acid, conjugated linoleic acid, or a mixture thereof.

Gum (sweet gum)

Non-limiting examples of gums include gum arabic, gum tragacanth, karaya gum, guar gum, gellan gum, tara gum, locust bean gum, tamarind gum, xanthan gum, locust bean gum, seneca gum, sclerotium rolfsii gum, and the like.

One or more matting agents

The cosmetic compositions of the present disclosure may comprise a matting agent. The amount of matting agent in the cosmetic composition can be, for example, from about 0.1 to about 10 wt.%, from about 0.1 to about 8 wt.%, from about 0.1 to about 6 wt.%, from about 0.1 to about 5 wt.%, from about 0.1 to about 4 wt.%, from about 0.1 to about 3 wt.%, from about 0.1 to about 2 wt.%, from about 0.1 to about 1 wt.%; about 0.25 to about 10 wt.%, about 0.25 to about 8 wt.%, about 0.25 to about 6 wt.%, about 0.25 to about 5 wt.%, about 0.25 to about 4 wt.%, about 0.25 to about 3 wt.%, about 0.25 to about 2 wt.%, about 0.25 to about 1 wt.%; about 0.5 to about 10 wt%, about 0.5 to about 8 wt%, about 0.5 to about 6 wt%, about 0.5 to about 5 wt%, about 0.5 to about 4 wt%, about 0.5 to about 3 wt%, about 0.5 to about 2 wt%, about 0.5 to about 1 wt%; about 0.75 to about 10 wt.%, about 0.75 to about 8 wt.%, about 0.75 to about 6 wt.%, about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%; from about 1 to about 10 wt.%, from about 1 to about 8 wt.%, from about 1 to about 6 wt.%, from about 1 to about 5 wt.%, from about 1 to about 4 wt.%, from about 1 to about 3 wt.%, or from about 1 to about 2 wt.%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Matting agents (also referred to as "matting fillers") refer to materials that impart greater transparency and hazy effect to skin tone and provide the skin with a natural and desirable appearance without imparting a greasy, reflective, and glossy appearance thereto. For this purpose, these materials are generally absorbent fillers, such as talc, silica, kaolin or fillers having light-scattering optical properties, which are known under the name "soft-focus" effect. In addition to reducing shine or oiliness, the matting agent can contribute to the overall texture and thickness of the cosmetic composition. Matting agents are typically (but not always) particulate materials or powders.

Cosmetic compositions containing a matting agent can be characterized by the following scheme. The test composition was applied at 2mg/cm using a mechanical film applicator ² Coated on a control card (sold by Erichsen company, prufkarte model 24/5-250 cm) ² ) The above. The composition was then dried at 37 ℃ overnight and its reflection measured using a variable angle reflectometer sold by Micromodule corporation. The intensity of specular reflection at 30 ° (R) and scattering at 90 ° (D) was measured continuously. The result obtained is a ratio R between specular reflection and diffuse reflection. Proportionally, the smaller the R value, the greater the matting effect provided by the filler. An R value of less than or equal to 2 generally indicates a matting effect. Matting agents according to the present disclosure include those which give an R-value of less than 1.5, and preferably less than 1, preferably at a level of 5% in the cosmetic composition.

Non-limiting examples of matting agents include: silica, clays, silicate derivatives, hydrophobic silica aerogel particles, porous silica microparticles, such as silica beads SB150 and SB700 from Miyoshi having an average size of 5 microns; sunsphere series-H products from Asahi Glass, such as Sunsphere H33, H51 and H53, each of size 3,5 and 5 μm, polytetrafluoroethylene powder, such as Clariant's PTFE Ceridust 9205F, with average size 8 microns, silicone resin powder, such as GE Silicone's Silicone Tospearl 145A, with average size 4.5 microns, hollow hemispherical Silicone particles, such as Takemoto Oil and Fail's NLK 500, NLK 506 and NLK510, acrylic copolymer powder, especially poly (methyl) acrylate,such as PMMA particles from Nihon Junyoki, jurymer MBI, with an average size of 8 microns, hollow PMMA spheres sold by Wackher company under the name Covabead LH 85, and vinylidene chloride/acrylonitrile/methyl methacrylate expanded microspheres sold under the name Expancel; wax powders, such as the paraffin particles MicroEase 114S from MicroPowders, with a mean size of 7 microns, polyethylene powders, especially comprising at least one ethylene/acrylic acid copolymer and especially consisting of ethylene/acrylic acid copolymers, such as the Flobeads EA 209 particles from Sumitomo (with a mean size of 10 microns), crosslinked elastomeric organopolysiloxane powders coated with silicone resins, especially with silsesquioxane resins, as described, for example, in U.S. Pat. No.5,538,793. Such elastomer powders are sold by the company Shin-Etsu under the names KSP-100, KSP-101, KSP-102, KSP-103, KSP-104 and KSP-105, polyamide (Nylon. RTM.) powders, such as the Orgasol type nylon 12 particles of Atofina, with an average size of 10 microns, polymethyl methacrylate (PMMA) type powders, talc, silica/TiO ₂ Or silica/zinc oxide composites, styrene/acrylic copolymer powders, and mixtures thereof.

Among the clays, mention may be made of clays of the smectite family, such as laponite, clays of the kaolinite family, such as kaolinite, dickite or nacrite, optionally modified clays of the following families: halloysite, dombasite, antigorite, magnetochlorite or pyrophyllite families, montmorillonite, beidellite, vermiculite, talc, stevensite, hectorite, saponite, chlorite, sepiolite and illite.

Clays include the following products, which are described, for example, in the following publications: minerals des argiles [ mineral of clay minerals ], s.cairle, s.henin, m.rautureau, second edition 1982, masson, which is incorporated herein by reference in its entirety. Natural clays are sedimentary rocks, mostly consisting of specific minerals, silicates, usually silicates of aluminium. Kaolin is a natural clay. The clay may also be synthetic. The clay may also be chemically modified with various compounds, such as acrylic acid, polysaccharides (e.g., carboxymethyl cellulose), or organic cations. In some cases, the cosmetic compositions of the present disclosure include a clay selected from kaolinite, montmorillonite, saponite, laponite, hectorite (including disteardimonium hectorite), and illite.

SILICA derivatives that may be mentioned include SILICA powders, such as porous SILICA microspheres sold under the name SILICA BEADS SB-700 by the company Miyoshi, SUNSPHERE H51, SUNSPHERE H33 and SUNSPHERE H53 sold by the company Asahi Glass; polydimethylsiloxane-coated amorphous silica microspheres sold by Asahi Glass company under the names SA SUNSPHERE H-33 and SA SUNSPHERE H-53; silica microbeads such as those sold under the name SB150 by Miyoshi corporation.

In some cases, the cosmetic composition comprises one or more matting agents selected from the group consisting of methyl methacrylate/glycol dimethacrylate crosspolymer, vinyl dimethicone/methicone silsesquioxane crosspolymer, methyl methacrylate crosspolymer, nylon-12, polyamides, polyethylene, talc, titanium dioxide, silica, aluminum starch octenyl succinate, clays (e.g., hectorite clays, including disteardimonium hectorite), silica, polymethylsilsesquioxane, and mixtures thereof. If present, the matting agent is preferably aluminium starch octenyl succinate.

One or more polyols

The cosmetic composition may comprise one or more polyols. If present, the amount of polyol in the cosmetic composition may be from about 1 to about 30 weight percent, based on the total weight of the cosmetic composition. For example, the cosmetic composition may comprise a water soluble solvent in an amount of from about 1 to about 30 wt.%, from about 1 to about 25 wt.%, from about 1 to about 20 wt.%, from about 1 to about 18 wt.%, from about 1 to about 16 wt.%, from about 1 to about 14 wt.%, from about 1 to about 12 wt.%, from about 1 to about 10 wt.%; about 5 to about 30 wt.%, about 5 to about 25 wt.%, about 5 to about 20 wt.%, about 5 to about 18 wt.%, about 5 to about 16 wt.%, about 5 to about 14 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%; about 10 to about 30 wt%, about 10 to about 25 wt%, about 10 to about 20 wt%, about 10 to about 18 wt%, about 10 to about 16 wt%, about 10 to about 14 wt%; about 12 to about 30 wt%, about 12 to about 25 wt%, about 12 to about 20 wt%, about 12 to about 18 wt%, about 12 to about 16 wt%; about 14 to about 30 wt%, about 14 to about 25 wt%, about 14 to about 20 wt%, about 14 to about 18 wt%; about 16 to about 30 wt%, about 16 to about 25 wt%, about 16 to about 20 wt%; about 18 to about 30 wt%, about 18 to about 25 wt%, or about 18 to about 20 wt%, including ranges and subranges thereof, based on the total weight of the cosmetic composition

Polyols are useful. Within the meaning of the present disclosure, the term "polyol" is understood to mean an organic molecule comprising at least two free hydroxyl groups. The polyol of the cosmetic composition may be a diol or a compound having a plurality of hydroxyl groups. In some cases, the one or more polyols are selected from C ₂ -C ₃₂ A polyol. The one or more polyols may be liquid at ambient temperature (25 ℃). The one or more polyols may have 2 to 32 carbon atoms, 3 to 16 carbon atoms, or 3 to 12 carbon atoms.

Non-limiting examples of polyols that may optionally be included in the cosmetic composition include and/or may be selected from alkanediols such as glycerol, 1,2, 6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentanediol, hexanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1, 4-diol, 2-ethyl-1, 3-hexanediol, 2-methyl-2, 4-pentanediol, octanediol, 1, 2-hexanediol, 1, 2-pentanediol, and 4-methyl-1, 2-pentanediol; glycol ethers, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, diethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-tert-butyl ether, diethylene glycol mono-tert-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-tert-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol monoisopropyl ether, sorbitol, sorbitan, glyceryl triacetate and mixtures thereof. The one or more polyols may optionally be glycols or glycol ethers such as, for example, the monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof, for example, the monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol, and alkyl ethers of diethylene glycol, for example, the monoethyl or monobutyl ether of diethylene glycol.

In some cases, the polyhydric alcohol includes glycerol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1, 3-butanediol, 2, 3-butanediol, 1, 4-butanediol, 3-methyl-1, 3-butanediol, 1, 5-pentanediol, tetraethylene glycol, 1, 6-hexanediol, 2-methyl-2, 4-pentanediol, polyethylene glycol, 1,2, 4-butanetriol, 1,2, 6-hexanetriol, and mixtures thereof. Polyol compounds may also be used. Non-limiting examples include aliphatic diols such as 2-ethyl-2-methyl-1, 3-propanediol, 3-dimethyl-1, 2-butanediol, 2-diethyl-1, 3-propanediol, 2-methyl-2-propyl-1, 3-propanediol, 2, 4-dimethyl-2, 4-pentanediol, 2, 5-dimethyl-2, 5-hexanediol, 5-hexene-1, 2-diol, and 2-ethyl-1, 3-hexanediol, and mixtures thereof.

In some cases, the polyol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, octanediol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol, and mixtures thereof.

One or more skin active agents

The cosmetic composition may optionally comprise one or more skin active agents, such as anti-aging agents, anti-wrinkle actives, antioxidants, humectants, moisturizing ingredients, depigmenting agents and/or agents for treating oily skin, and the like. The amount of skin active agent that may be included in the cosmetic composition is from greater than zero to about 5% by weight, based on the total weight of the composition. For example, the total amount of skin active agents can be from greater than zero to about 5 wt%, from greater than zero to about 4 wt%, from greater than zero to about 3 wt%, from greater than zero to about 2 wt%; about 10ppm to about 5 wt% (50,000ppm), about 10ppm to about 2.5 wt% (25,000ppm), about 10ppm to about 1 wt% (10,000ppm), about 10ppm to about 0.5 wt% (5,000ppm), about 10ppm to about 0.3 wt% (3,000ppm), about 10ppm to about 0.2 wt% (2,000ppm), about 10ppm to about 0.1 wt% (1,000ppm), about 10ppm to 500ppm; about 0.05 to about 5 wt%, about 0.05 to about 2.5 wt%, about 0.05 to about 1 wt%, about 0.05 to about 0.5 wt%; about 0.1 to about 5 wt%, about 0.1 to about 2.5 wt%, about 0.1 to about 1 wt%, about 0.1 to about 0.5 wt%; about 1 to about 5 wt%, about 1 to about 4 wt%, about 1 to about 3 wt%; about 2 to about 5 wt%, about 2 to about 4 wt%; or from about 3 to about 5 weight percent, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

The following provides a non-limiting discussion of skin active agents that may be included in a cosmetic composition in some cases:

humectant and/or moisturizing ingredient

Examples of humectant and/or moisturizing ingredients include glycerol and derivatives thereof, urea and derivatives thereof, in particular hydro, hyaluronic acid, sodium pyridonate, xylitol, serine, ectoin and derivatives thereof, collagen, plankton, an extract of impartation cylindra sold under the name molist 24 by Sederma, an acrylic acid homopolymer of Lipidure-HM by NOF Corporation, a mixture of beta-glucan and in particular carboxymethyl beta-glucan sodium Mibelle-AG-Biochemistry, passion oil sold under the name NutraLipids by Nestle, a mixture of apricot oil, corn oil and rice bran oil, C-glycoside derivatives, in particular C-13-D-xylopyranoside-2-hydroxypropane, in the form of an active substance sold under the name "Mexoryl SBB" by Chimex Corporation in a water/propylene glycol mixture (60/40% by weight), a 30% by weight solution of neharyl alcohol, a Zinc rich solution sold under the name of collagen Marine collagen cellulose (hyaluronic acid), and a Marine collagen extract sold under the name of collagen Marine polysaccharide.

Decolorizing agent

Depigmenting agents which may be incorporated into the cosmetic composition include those selected from: alpha and beta arbutin, eosin (lucinol) and derivatives thereof, kojic acid, resorcinol and derivatives thereof, gentisic acid (homogentisic), methyl gentisate or gentisate, diacids, calcium D pantothenate sulfonates, lipoic acid, ellagic acid, vitamin B3, linoleic acid and derivatives thereof, certain compounds derived from: plants such as chamomile, bearberry, aloe (vera, ferox, bardenis), mulberry, scutellaria, kiwi fruit sold by Gattefosse (kiwi fruit), moutan root extract, such as sold by Ichimaru Pharcos under the name Liquid Botanpi Be, brown sugar extract (sugarcane), such as sold by Taiyo Kagaku under the name Liquid Molasses, this list is non-exhaustive. Specific depigmenting agents include alpha and beta arbutin, kojic acid, resorcinol and derivatives, calcium D-pantetheinesulfonate, lipoic acid, ellagic acid, vitamin B3, kiwi fruit sold by Gattefosse (actinidia chinensis), moutan root extract, such as the product sold under the name Botanpi Liquid B by Ichimaru Pharcos.

Anti-wrinkle active agent

The cosmetic composition may comprise one or more anti-wrinkle active agents. The term "anti-wrinkle active agent" refers to a natural or synthetic compound that produces a biological effect, e.g., synthesis and/or increased activity of certain enzymes, when in contact with a wrinkled area of skin, which has the effect of reducing the appearance of wrinkles and/or fine lines. Exemplary anti-wrinkle actives may be selected from: desquamating agents, anti-glycation agents, NO synthase inhibitors, agents that stimulate the synthesis of dermal or epidermal macromolecules and/or prevent their degradation, agents that stimulate the proliferation of fibroblasts and/or keratinocytes, or agents that are reducing agents for stimulating the differentiation of keratinocytes; muscle relaxant and/or dermal relaxant, anti-radical agent and mixtures thereof. Examples of such compounds are: adenosine and its derivatives and retinoids other than retinol (as described above), ascorbic acid and its derivatives such as magnesium ascorbyl phosphate and ascorbyl glucoside; nicotinic acid and its precursors such as niacinamide; ubiquinone; glutathione and its precursors such as L-2-oxothiazolidine-4-carboxylic acid, the compound C-glycosides and derivatives thereof described in, inter alia, EP-1345919, in particular C-beta-D-xylopyranoside-2-hydroxy-propane, plant extracts including cumin and olive leaf extracts, and plants and their hydrolysates such as rice protein hydrolysate or soy protein; seaweed extract, in particular laminaria, bacterial extract, sapogenins such as diosgenin and dioscorea extract, in particular wild yam, comprising: alpha-hydroxy acids, f 3-hydroxy acids, such as salicylic acid and n-octanoyl-5-salicylic acid oligopeptides and pseudodipeptides and acyl derivatives thereof, in particular the acids {2- [ acetyl (3-trifluoromethyl-phenyl) -amino ] -3-methyl } acetic acid and lipopeptides sold by the companies under the trade names SEDERMA matrix 500 and matrix 3000; lycopene, manganese salts and magnesium salts, in particular gluconate, and mixtures thereof. In at least one case, the cosmetic composition comprises an adenosine derivative, such as a non-phosphate derivative of adenosine, for example in particular 2' -deoxyadenosine, 2',3' -isopropylidene adenosine; toyocamycin, 1-methyladenosine, N-6-methyladenosine; adenosine N-oxide, 6-methylmercaptopurine nucleoside, and 6-chloropurine nucleoside. Other derivatives include adenosine receptor agonists such as phenylisoadenosine ("PIA"), 1-methylisoguanosine, N6-Cyclohexyladenosine (CHA), N6-Cyclopentyladenosine (CPA), 2-chloro-N6-cyclopentyladenosine, 2-chloroadenosine, N6-phenyladenosine, 2-phenylaminoadenosine, MECA, N6-phenethyladenosine, 2-p- (2-carboxy-ethyl) phenethyl-amino-5 '-N-ethylcarboxamidoadenosine (CGS-21680), N-ethylcarboxamidoadenosine (NECA), 5' (N-cyclopropyl) -carboxamidoadenosine, DPMA (PD 129.944), and Adidil.

Skin active agent for oily skin

The cosmetic composition may optionally comprise an active agent to address oily skin. These agents may be sebum-regulating agents or anti-seborrheic agents capable of regulating the activity of sebaceous glands. Exemplary skin active agents for combating oily skin include: retinoic acid, retinol, benzoyl peroxide, sulfur, vitamin B6 (pyridoxine or) chloride, selenium, salicornia-cinnamon extract mixture, tea and caprylylglycine for example-sepicotrol A5 from Seppic-in particular cinnamon, a mixture of sarcosine and caprylylglycine sold under the trade name sepicotrol A5 by Seppic-zinc salts such as zinc gluconate, zinc pyrrolidone formate (or zinc pyridonate), zinc lactate, zinc aspartate, zinc formate, zinc salicylate 20, zinc cysteine; derivatives, in particular copper and copper piroxonate as extracts of Cuivridone Solabia-plants from arnica, cinchona, clove, hop, hypericum, mentha pipenta 25 rosemary, sage and thyme, all sold for example by Maruzen-an extract of meadowsweet (spiraea ulmaria), such as those sold under the name sebomonin by Silab-an extract of broad-leaved macroalgae (alga lamaria sacchara), such as those sold under the name phytoncine by biotech, such as those sold under the name phytosine 30-a root extract of the sanguisorba americana mixture (sanguisorba/sanguisorba longifolia), ginger (ginger) and cinnamon bark (cinnamon), such as a linseed extract sold under the name sebastop by Solabia, such as those sold under the name phellodendron by lucida by lucarnica, such as those sold under the name BG by lucezen Meyer or by sabia serrata liquid such as the extract of phellodendron amurense, such as those sold under the names berba oil by lucernia megalosa and extract of chervilia (SEB) such as extracts of chervilia, such as those sold under the names perzia oil, such as myrobalam extract of myrobalam, such as extracts of myrobalan extract sold under the name SEB; -Pygeum africanum extracts, such as those sold under the name Pygeum africanum sterol lipid extract by Euromed-saw palmetto extracts, such as those sold under the name vision Sabal by active International and those sold by Euromed corporation-plantain blends, extracts of berberis lividans and sodium salicylate 20, such as those sold under the name sebclear Rahn-Clove extracts, such as those sold under the name Clove extract powder by Maruzen-argan oil, such as those sold under the name lipofructan Laboratories serologic; 25-lactoprotein filtrates (1 active protein extracts), such as those sold under the name Normaseb by Sederma-seaweed laminaria extracts, such as those sold under the name lamiraghane by biotechmare-oligosaccharide seaweed palmetto, such as those sold under the name phycoscharide 30AC by Codif-extracts, such as those sold under the name Policosanol by sabina, sulfonated shale oils, such as those sold under the name ichtoyol pall by Ichthyol-extracts of the meadowfoam (spiraea ulmaria), such as those sold under the name Cytobiol ulmair by societil lipid-sebacic acids, particularly those sold under the name sodium polyacrylate gel by Sederma-extracts, such as those sold under the name sola gel-extracts by tubers and sold under the name of alkyl sulfonate chain modified dextrans-extracts, such as those sold under the name benthia by Arch under the name polio, such as those sold under the name berba extracts by berba, such as those sold under the name nigra gel, and grafted with acacia gum, such as those sold under the name rubberba extracts, such as the name acacia gum OR powder, such as the name acacia gum powder OR gum. 20-phthalimidoperoxycaproic acid-tri (C12-C13) citrate ester sold by Sasol under the name cosmecol. Trialkyl (C14-C15) citrates sold by Sasol under the name COSMACOL. RTM. ECL-10-hydroxydecanoic acid, including the mixture-October 25 hydroxydecanoate, sebacic acid and 1, 10-decanediol, such as those sold under the name Acnacidol BG by Vincience, and mixtures thereof.

Antioxidant agent

Vitamin C and derivatives may be used, including ascorbic acid, sodium ascorbate and the fat soluble esters tetrahexyldecyl ascorbate and ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl glucoside, glucosamine ascorbate, ascorbyl acetate, and the like. In addition, extracts from plants containing high amounts of vitamin C, such as camu fruit (Myrciaria dubia), acerola (acerola), emblica (Emblica officinalis), and bioflavonoids from rosehips and citrus, including water-soluble bioflavonoids, such as hesperidin methyl chalcone, may also be used.

Sesame (Sesamum indicum) or sesame lignan (lignan) may also be added. Sesame and its lignans (fiber compounds related to sesame) act as antioxidants. Sesame seed lignans significantly enhance vitamin E activity.

Other antioxidants include tocopherols (e.g., d-alpha-tocopherol, d-beta-tocopherol, d-gamma-tocopherol, d-delta-tocopherol), tocotrienols (e.g., d-alpha-tocotrienol, d-beta-tocotrienol, d-gamma-tocotrienol, d-delta-tocotrienol), and vitamin E (alpha-tocopherol acetate). These compounds may be isolated from natural sources, prepared by synthetic means, or mixtures thereof. Vitamin E products enriched in tocotrienols can be obtained by fractionating a vitamin E product to remove a portion of the biological phenols and recovering a more highly concentrated tocotrienol product. Useful tocotrienols are natural products isolated from wheat germ oil, cereal or palm oil, for example using high performance liquid chromatography, or from barley, distillers grains or oats by alcohol extraction and/or molecular distillation. The term "tocotrienol" as used herein includes tocotrienol-rich fractions obtained from these natural products as well as pure compounds. The increased glutathione peroxidase activity protects the skin from oxidative damage.

In addition, carotenoids, particularly of the xanthophyll type, are useful antioxidants that may be used. Xanthophyll carotenoids include molecules such as lutein (lutein), canthaxanthin (canthaxanthin), cryptoxanthin, zeaxanthin and astaxanthin. Xanthophylls protect compounds such as vitamin a, vitamin E and other carotenoids.

Flavonoids

The skin active agent may be selected from antioxidants of flavonoids. In some cases, the flavonoid is a flavanone (a derivative of 2, 3-dihydro-2-phenylbenzopyran-4-one). Flavanones include: butin, eriodictyol, hesperetin, hesperidin, homoeriodictyol, isosakuranetin (isosakuranetin), naringenin, naringin, pinocembrin, poncirin, sakuranetin (sakuranetin), sakuranetin, and 7-O-methyl eriodictyol (Sterubin). The flavonoid may be flavanonol (a derivative of 3-hydroxy-2, 3-dihydro-2-phenylbenzopyran-4-one). Flavanols include: taxifolin (taxifolin), aurantiol (aromaderin), chrysandroside A, chrysandroside B, xaacteol, astilbin and fustin. The flavonoid may be a flavone (derivative of 2-phenylbenzopyran-4-one). The flavone comprises: apigenin (Apigenin), luteolin, citrus flavone (tangeritin), chrysin (Chrysin), baicalein, scutellarein, wogonin, synthetic flavone: diosmin (Diosmin) and flavoxate. The flavonoid may be flavonol (a derivative of 3-hydroxy-2-phenylbenzopyran-4-one). Flavonols include: 3-hydroxyflavone, azalea flavin, fisetin, galangin, gossypetin, kaempferide, kaempferol, isorhamnetin, morin, myricetin, naringenin (natsudaiain), patchoulol (Pachypodol), quercetin, methyl rhamnosine, rhamnetin (Rhamnetin), azaleatin (Azalein), hyperoside, isoquercitrin, kaempferide, myricitrin, quercitrin, robinin (Robinin), rutin, spiraeoside, xanthorhamnonin (Xanthorhannin), dehydrophellodendrin (Amurenin), icariin and troxerutin. The flavonoid may be flavan-3-ol (a derivative of 2-phenyl-3, 4-dihydro-2H-benzopyran-3-ol). Flavan-3-ols include: catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, epicatechin (Epiafzelechin), fisetinol (Fisetinidol), guibourtiidol, mesquitol, and robinetininol. The flavonoid may be flavan-4-ol (a derivative of 2-phenylchroman-4-ol). Flavan-4-ols include: apiforol and Luteoforol. The flavonoid may be an isoflavone (derivative of 3-phenylbenzopyran-4-one). Isoflavones include: genistein, daidzein (Daidzein), biochanin A, formononetin and equol metabolites from Daidzein (Daidzein).

The antioxidant may be anthocyanidin (a derivative of a 2-phenylbenzopyrylium cation). Anthocyanins include: aurantidin (aurantidin), cyanidin, delphinidin, europinidin, luteolin (Luteolinidin), pelargonidin (Pelargonidin), malvidin (Malvidin), peoniflorin (Peonidin), morning glory pigment (petronidin), rose pigment (Rosinidin) and xanthone.

The antioxidant may be dihydrochalcone (derivatives of 1, 3-diphenyl-1-propanone). Dihydrochalcones include: phloretin, dihydrochalcone phloretin phlorizin, aspalathin, naringin dihydrochalcone, neohesperidin dihydrochalcone, and nothofarin. Without limiting the mode of action of the present invention, dihydrochalcones may exert an antioxidant effect by reducing reactive free radicals, such as reactive oxygen species and reactive nitrogen species.

The antioxidant may be an anthocyanin. Anthocyanins and their derivatives are antioxidants. Anthocyanins comprise a class of flavonoid compounds responsible for the red, purple and blue colors of many fruits, vegetables, grains and flowers, which are naturally occurring water-soluble compounds. In addition, anthocyanins are collagenase inhibitors. Inhibition of collagenase helps to prevent and reduce wrinkles caused by decreased skin collagen, increase skin elasticity, and the like. The anthocyanin can be obtained from any part of various plant sources, such as fruit, flower, stem, leaf, root, bark, or seed. One skilled in the art will appreciate that certain parts of the plant may contain higher natural levels of anthocyanins, and thus these parts are used to obtain the desired anthocyanins. In some cases, the antioxidant may include one or more betacyanins. Betacyanin, like anthocyanin, is available from natural sources and is an antioxidant.

The antioxidant may be a phenylpropanoid (derivative of cinnamic acid). The phenylpropanoids include: cinnamic acid, caffeic acid, ferulic acid, trans-ferulic acid (including its antioxidant pharmacore 2, 6-dihydroxyacetopenome), 5-hydroxyferulic acid, sinapic acid (sinapic acid), coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, eugenol, piperonyl alcohol (Chavicol), safrole, P-coumaric acid and sinapinic acid (sinapinic acid). Without limiting the mode of action of the invention, phenylpropanoids neutralize free radicals.

The antioxidant may be chalcone (a derivative of 1, 3-diphenyl-2-propen-1-one). Chalcones include: butein, ocainin (okannin), carthamin, mariside (Marein), bushikone (Sophoradin), xanthohumol (Xanthohumol), flavokavin A, flavokavin B, flavokavin C and synthetic Safalcone.

The antioxidant may be a curcuminoid. Curcuminoids include: curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and tetrahydrocurcuminoids. Curcumin and tetrahydrocurcuminoids can be derived from the rhizome of turmeric. Tetrahydrocurcumin (a metabolite of curcumin) has been found to be a more potent antioxidant than curcumin and to be more stable.

The antioxidant may be tannin. Tannins include: tannin, terflavin B, glucogallin (glucoprotein), dgallic acid and quercitin acid (Quercitannic acid).

The antioxidant may be stilbene (stilbenoid). The stilbenes comprise: resveratrol, pterostilbene, and piceatannol. Resveratrol may include, but is not limited to, 3,5,4 '-trihydroxystilbene, 3,4,3',5 '-tetrahydroxystilbene (piceatannol), 2,3',4,5 '-tetrahydroxystilbene (oxyresveratrol), 4' -dihydroxystilbene and its alpha and beta glucoside, galactoside and mannoside derivatives.

The antioxidant may be coumarin (a derivative of 2H-benzopyran-2-one). Coumarins include: 4-hydroxycoumarin, umbelliferone, aesculetin (Aesculetin), pheomedin (Herniarin), aurapten (Auraptene), and dicoumarin.

The antioxidant may be a carotenoid. Carotenoids include: beta-carotene, alpha-carotene, gamma-carotene, beta-cryptoxanthin, lycopene, lutein, and idebenone (idebenone). Semen Sesami or semen Sesami lignanoid may also be added. Sesame and its lignans (fiber compounds related to sesame) act as antioxidants. The sesame seed lignans significantly enhance the activity of vitamin E.

The antioxidant may be: xanthone, butylated hydroxytoluene, 2, 6-di-tert-butylphenol, 2, 4-dimethyl-6-tert-butylphenol, gallic acid, eugenol, uric acid, alpha-lipoic acid, ellagic acid, chicoric acid, chlorogenic acid, rosmarinic acid, salicylic acid, acetylcysteine, S-allylcysteine, pyranoisoflavone (Barbiger one), chebulagic acid (Chebulagic acid), edaravone (edaravone), ethoxyquin, glutathione, hydroxytyrosol, idebenone, melatonin, N-acetyl serotonin, nordihydroguaiaretic acid, oleocanthal, oleuropexol, paradol, piceatannol, probucol, propyl gallate, protocatechuic acid, pyritinol, rutin, linolerucin diglucoside, sesamin, sesamol, silybin, theaflavin digallate, thmoonone, trolox, methionine, thioctic acid, fatty acids and thioctic acids such as antioxidants or thioctic acids.

One or more chelating agents other than trisodium ethylenediamine disuccinate

In addition to trisodium ethylenediamine disuccinate, the cosmetic composition may optionally comprise a chelating agent, as described above. The amount of chelant other than trisodium ethylenediamine disuccinate present in the cosmetic composition can be, for example, from about 0.1 to about 10 wt.%, from about 0.1 to about 8 wt.%, from about 0.1 to about 6 wt.%, from about 0.1 to about 5 wt.%, from about 0.1 to about 4 wt.%, from about 0.1 to about 3 wt.%, from about 0.1 to about 2 wt.%, from about 0.1 to about 1 wt.%; about 0.25 to about 10 wt%, about 0.25 to about 8 wt%, about 0.25 to about 6 wt%, about 0.25 to about 5 wt%, about 0.25 to about 4 wt%, about 0.25 to about 3 wt%, about 0.25 to about 2 wt%, about 0.25 to about 1 wt%; about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 10 wt.%, about 0.75 to about 8 wt.%, about 0.75 to about 6 wt.%, about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%; from about 1 to about 10 wt.%, from about 1 to about 8 wt.%, from about 1 to about 6 wt.%, from about 1 to about 5 wt.%, from about 1 to about 4 wt.%, from about 1 to about 3 wt.%, or from about 1 to about 2 wt.%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Non-limiting examples of chemical chelators include amino trimethyl phosphonic acid, beta alanine diacetic acid, cyclodextrin, citric acid, cyclohexanediamine tetraacetic acid, diethylenetriamine pentamethylene phosphonic acid, diethanolamine N-acetic acid, ethylenediaminetetraacetic acid (EDTA or YH) ₄ ) And its sodium salt (YH) ₃ Na、Y ₂ H ₂ Na ₂ 、YHNa ₃ And YNA ₄ ) Potassium salt of (YH) ₃ K、Y ₂ H ₃ K ₃ And YK ₄ ) Calcium disodium and diammonium salts and their salts with triethanolamine (TEA-EDTA), etidronic acid, mucic acid (galactanic acid), hydroxyethylethylenediaminetetraacetic acid (HEDTA) and its trisodium salt, gluconic acid, glucuronic acid, nitrilotriacetic acid (NTA) and its trisodium salt, triaminepentaacetic acid, phytic acid, ribonic acid, diammonium hydrogen citrate, azacycloheptanediphosphodiodium phosphate, disodium dihydrogen pyrophosphate, hydroxypropyl cyclodextrin, methylcyclodextrin, potassium tripolyphosphate, pentasodium aminotrimethylene phosphonate, pentasodium ethylenediaminetetramethylenephosphonate, pentasodium diethylenetriaminepentaacetate, sodium tripolyphosphate, potassium citrate, potassium EDTMP potassium, EDTMP sodium, chitosan methylenephosphonic acid sodium, sodium hexametaphosphate, sodium metaphosphate, potassium polyphosphate, sodium trimetaphosphate, sodium dihydroxyethylglycinate, potassium gluconate, sodium glucophoeptate, sodium glyceropolyether-1 polyphosphate, potassium tetrapotassium pyrophosphate, triethanolamine polyphosphate, TEA), tetrasodium pyrophosphate, trisodium phosphate, sodium triphosphorylmethylamine oxide (sodium triphosphate), sodium orthosilicate, sodium phytate, sodium polydimethylglycylphenol sulfonate, tetrahydroxyethylethylene diamine, tetrahydroxypropylethylenediamine, tetrapotassium isethionate, tetrasodium iminodisuccinate, trisodium ethylenediamine disuccinate, hydroxyethyliminodiacetic acid, disodium acetate, dimercaptopropanol, deferoxamine mesylate, zylox, and/or the iron chelators disclosed and claimed in international patent application WO 94/61338, which are incorporated herein in their entirety for all purposes. Examples of biological chelators include metallothionein, transferrin, calmodulin, and sodium chitosan methylenephosphonate.

Nonionic emulsifiers other than polyglycerol-3-methyl glucose distearate

In some cases, the cosmetic composition may further comprise a nonionic emulsifier other than polyglycerol-3 methyl glucose distearate. The amount of nonionic emulsifier other than polyglycerol-3 methyl glucose distearate may be from about 0.1 to 20 wt.%, from about 0.1 to about 18 wt.%, from about 0.1 to about 16 wt.%, from about 0.1 to about 14 wt.%, from about 0.1 to about 12 wt.%, from about 0.1 to about 10 wt.%, from about 0.1 to about 8 wt.%, from about 0.1 to about 7 wt.%, from about 0.1 to about 6 wt.%, from about 0.1 to about 5 wt.%; about 1 to about 20 wt.%, about 1 to about 18 wt.%, about 1 to about 16 wt.%, about 1 to about 14 wt.%, about 1 to about 12 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%; about 4 to about 20 wt.%, about 4 to about 18 wt.%, about 4 to about 16 wt.%, about 4 to about 14 wt.%, about 4 to about 12 wt.%, about 4 to about 10 wt.%, about 4 to about 8 wt.%, or about 4 to about 7 wt.%, including all ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Emulsifiers are commonly used to incorporate oils and/or fatty compounds into hydrophilic media, such as aqueous media, to form oil-in-water emulsions. However, in some cases, emulsifiers may be used to incorporate a hydrophilic phase (e.g., an aqueous medium) into an oil or fat phase to form a water-in-oil emulsion. The cosmetic composition comprises one or more nonionic emulsifiers. However, additional emulsifiers, such as amphoteric, anionic and/or cationic emulsifiers, may also be included (or excluded).

For O/W emulsions, examples of emulsifiers which may be mentioned include nonionic emulsifiers, such as the oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; an oxyalkylenated fatty acid ester of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty acid esters; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers; sugar esters, such as sucrose stearate; and mixtures thereof. A more exhaustive but non-limiting list of useful nonionic emulsifiers is provided below under the heading "nonionic emulsifiers".

In some cases, a cosmetic composition containing a natural oil comprises two or more nonionic emulsifiers. In particular one or more nonionic emulsifiers having an HLB of 10 or more and one or more nonionic emulsifiers having an HLB of 5 or less. The total amount of these emulsifiers may be such that the final HLB of the hair treatment composition is within +/-0.5 of the HLB of the natural oil in the cosmetic composition. This typically results in a final HLB of the emulsified natural oil in the hair treatment composition in the range of from about 6 to about 8.

Examples of emulsifiers that may be mentioned include nonionic emulsifiers, such as the oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; an oxyalkylenated fatty acid ester of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty acid esters; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers; sugar esters, such as sucrose stearate; and mixtures thereof.

Non-limiting examples of nonionic emulsifiers include polyglycerol-based emulsifiers, polyol esters, glycerol ethers, oxyethylenated ethers, oxypropylenated ethers, glycol polymers, sorbitan esters, polysorbates, and mixtures thereof. In some cases, the one or more nonionic emulsifiers are selected from polyglyceryl 10-stearate, polyglyceryl-3-decanoate, polyglyceryl-3-diisostearate, polyglyceryl-3 methyl glucose distearate, or mixtures thereof. In at least one instance, the cosmetic composition may further comprise at least one of polyglycerol 10-stearate, polyglycerol-3-decanoate, polyglycerol-3-diisostearate, or polysorbate 20 in addition to polyglycerol-3 methylglucose distearate.

One or more pH regulators

The cosmetic composition may comprise one or more pH adjusting agents to increase or decrease the total pH of the cosmetic composition. For example, one or more acids may be included to lower the pH of the cosmetic composition. Examples of suitable acids for lowering the pH of the cosmetic composition include, but are not limited to, citric acid, acetic acid, and the like. The cosmetic composition may comprise one or more bases, such as sodium hydroxide, potassium hydroxide, and the like, to lower the pH of the cosmetic composition. Additional or alternative acids and bases suitable for adjusting the pH of the cosmetic composition will be readily known to those of ordinary skill in the art.

The cosmetic composition may, desirably, have a pH of from about 4 to about 7, preferably from about 4.5 to about 6.5 or from about 5.5 to about 6.5. In one instance, the pH of the cosmetic composition is 6 or about 6. The amount of pH adjusting agent in the cosmetic composition can be based on the desired pH of the final cosmetic composition and/or product. For example, the total amount of pH adjusting agents can be about 0.05 to about 20 weight percent, based on the total weight of the composition. In some cases, the total amount of pH adjusting agent is about 0.05 to about 15 weight percent, about 0.5 to about 10 weight percent, about 1 to about 5 weight percent, about 1.5 to about 4 weight percent, or about 2.0 to about 3 weight percent, including ranges and subranges therebetween, based on the total weight of the composition.

Water (I)

The total amount of water in the cosmetic composition can vary, but is typically from about 50 to about 95 weight percent, based on the total weight of the cosmetic composition. In some cases, the total amount of water is from about 50 to about 90 weight percent, from about 50 to about 85 weight percent, from about 50 to about 80 weight percent; about 55 to about 95 wt%, about 55 to about 90 wt%, about 55 to about 85 wt%, about 55 to about 80 wt%; about 60 to about 95 wt.%, about 60 to about 90 wt.%, about 60 to about 85 wt.%, about 60 to about 80 wt.%; about 65 to about 95 wt.%, about 65 to about 90 wt.%, about 65 to about 85 wt.%, or about 65 to about 80 wt.%; about 70 to about 95 wt%, about 70 to about 90 wt%, about 70 to about 85 wt%, about 70 to about 80 wt%, including ranges and subranges therebetween, based on the total weight of the cosmetic composition.

Production method

The present disclosure also relates to methods or processes for preparing/manufacturing the cosmetic compositions described herein. It also includes products made by these methods or processes.

The method of making certain embodiments of the cosmetic composition comprises forming an oil phase and forming a separate aqueous phase (aqueous), heating the two phases and combining while warm. Each phase may be heated to the same temperature or may be heated to a different temperature.

The thickener may be added to the aqueous phase of the cosmetic composition. However, in some cases, one or more emulsifiers and/or thickeners are added to the oil phase. Additionally or alternatively, a thickener may be added after emulsification-for example, ammonium polyacrylyldimethyltaurate may be added after emulsification.

After the oil and water phases are combined to form the emulsion, the composition is typically allowed to cool. Additional components may be added during or after the emulsification time. For example, certain perfumes, colorants, exfoliants, actives, etc. may be added to the aqueous phase, the fatty phase, or after emulsification.

Application method

The present disclosure also relates to methods of using the cosmetic compositions described herein. For example, the cosmetic composition may be used in a method comprising applying the cosmetic composition to the skin of a human. In some cases, the composition is applied to the face. In addition, the cosmetic compositions may be used in methods of treating and/or repairing skin damage (e.g., photoaging damage), as well as reducing the appearance of skin wrinkles, dark spots, and uneven skin texture. The above method is non-therapeutic.

The cosmetic composition may be applied once daily, twice daily or more than once or twice daily. In some cases, the composition is applied before and after bedtime. In other cases, the composition is administered in the morning. In other cases, the composition may be applied immediately after washing the skin. The composition may be used once, or for a series of days, weeks or months. For example, the composition may be used daily for a period of 1,2, 3,4, 5, 6, 7, 8 or more weeks or months.

Detailed Description

In certain embodiments, the cosmetic compositions of the present disclosure generally comprise:

-from about 0.01 to about 3 wt%, preferably from about 0.05 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent retinol;

-from about 0.01 to about 1 wt%, preferably from about 0.01 to about 0.8 wt%, more preferably from about 0.05 to about 0.8 wt% of tetra-di-tert-butyl hydroxyhydrocinnamate;

-from about 0.01 to about 3 wt%, preferably from about 0.01 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent trisodium ethylenediamine disuccinate;

-about 0.5 to about 7 wt%, preferably about 0.75 to about 6 wt%, more preferably about 0.75 to about 5 wt% of polyglycerol-3 methyl glucose distearate;

-from about 0.9 to about 7 wt%, preferably from about 1 to about 6 wt%, more preferably from about 1 to about 5 wt% of sodium polyacrylate;

-from about 0.5 to about 8 wt%, preferably from about 0.5 to about 6 wt%, more preferably from about 1 to about 5 wt% of an oil phase comprising silicone or at least one of the following: coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina sativa seed oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio nut oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof;

-water, preferably from about 50 to about 95 wt% water, more preferably from about 60 to about 95 wt% water, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

In a further embodiment, there is provided a product comprising:

(i) A cosmetic composition in the form of an oil-in-water emulsion comprising:

-from about 0.01 to about 3 wt%, preferably from about 0.05 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent retinol;

-from about 0.01 to about 1 wt%, preferably from about 0.01 to about 0.8 wt%, more preferably from about 0.05 to about 0.8 wt% of tetra-di-tert-butyl hydroxyhydrocinnamate;

-from about 0.01 to about 3 wt%, preferably from about 0.01 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent trisodium ethylenediamine disuccinate;

-about 0.5 to about 7 wt%, preferably about 0.75 to about 6 wt%, more preferably about 0.75 to about 5 wt% of polyglycerol-3 methyl glucose distearate;

-from about 0.9 to about 7 wt%, preferably from about 1 to about 6 wt%, more preferably from about 1 to about 5 wt% of sodium polyacrylate;

-from about 0.5 to about 8 wt%, preferably from about 0.5 to about 6 wt%, more preferably from about 1 to about 5 wt% of an oil phase comprising silicone or at least one of the following: coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina blue seed oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio nut oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof; and

-water, preferably from about 50 to about 95 wt% water, more preferably from about 60 to about 95 wt% water; and

(ii) Containers containing cosmetic compositions include, for example, non-protective packaging such as those without an aluminum layer and/or with a pump for dispensing the cosmetic composition.

In yet further embodiments, the cosmetic compositions of the present disclosure generally consist of:

-from about 0.01 to about 3 wt%, preferably from about 0.05 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent retinol;

-from about 0.01 to about 1 wt%, preferably from about 0.01 to about 0.8 wt%, more preferably from about 0.05 to about 0.8 wt% of tetra-di-tert-butyl hydroxyhydrocinnamate;

-from about 0.01 to about 3 wt%, preferably from about 0.01 to about 2.5 wt%; more preferably from about 0.1 to about 2 weight percent trisodium ethylenediamine disuccinate;

-about 0.5 to about 7 wt.%, preferably about 0.75 to about 6 wt.%, more preferably about 0.75 to about 5 wt.% of polyglycerol-3 methylglucose distearate;

-from about 0.9 to about 7 wt%, preferably from about 1 to about 6 wt%, more preferably from about 1 to about 5 wt% of sodium polyacrylate;

-from about 0.5 to about 8 wt%, preferably from about 0.5 to about 6 wt%, more preferably from about 1 to about 5 wt% of an oil phase comprising silicone or at least one of the following: coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina sativa seed oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio nut oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof;

-water, preferably from about 50 to about 95 wt% water, more preferably from about 60 to about 95 wt% water;

optionally, from about 0.05 to about 5 wt%, preferably from about 0.05 wt% to about 4 wt%, more preferably from about 0.05 wt% to about 3 wt% of a thickener other than sodium polyacrylate, such as those selected from the group consisting of ammonium polyacrylyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymer, sodium polyacrylate, acrylate copolymers, polyacrylamide, carbomer, acrylate/C10-30 alkyl acrylate crosspolymer, acrylate/beheneth-25 methacrylate copolymer, and mixtures thereof;

optionally, from about 0.1 to about 10 wt%, preferably from about 0.25 to about 8 wt%, more preferably from about 0.5 to about 6 wt% of a matting agent, for example aluminium starch octenyl succinate;

optionally, from about 1 to about 30 wt%, preferably from about 5 to about 25 wt%, more preferably from about 10 to about 20 wt% of a polyol including, for example, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, octylene glycol, 1, 3-propanediol, glycerol, diglycerol, polyethylene glycol, or mixtures thereof;

optionally, a skin active agent, such as those selected from hyaluronic acid, lanolin, niacinamide citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, octanoyl salicylic acid, retinoids, retinal, retinol, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, and mixtures thereof, in an amount of up to about 5 wt%, preferably from about 0.05 to about 5 wt%, more preferably from about 0.1 to about 4 wt%, wherein the cosmetic composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.

Examples

The following examples are provided primarily for the purpose of illustrating the benefits achieved by embodiments of the present disclosure. The examples are intended to be illustrative of the art and not limiting in nature.

Example 1

Example 2

Example composition a and eight commercial benchmarks (commercial benchmarks B-I) were stored in a controlled environment chamber in an opaque container to determine the stability of retinol over a period of eight weeks. The temperature of the controlled environment chamber was set to 45 ℃. Example composition a was stored in a container in which the composition was dispensed using a standard pump (in a container with a standard cosmetic pump having a removable top). The containers for the eight commercial benchmarks and the amounts of retinol remaining are provided in the table below.

Examples composition a and commercial references B-I were evaluated using high performance liquid chromatography to determine the retinol content remaining after storage. High performance liquid chromatography was performed as follows: using a Kinetex XB C-18 column, with 25% methanol and 75% ACN mobile phase, at a flow rate of 2mL/min and a temperature of 45 ℃. The detector is a UV/Vis detector. High performance liquid chromatography evaluates 10 μ L samples at scanning wavelengths from 250nm to 400nm during a6 minute scanning run.

The term "INCI" is an abbreviation of international nomenclature for cosmetic ingredients, which is a name system provided by the international commission on naming of the personal care product association to describe personal care ingredients.

As used herein, all ranges provided are intended to include each specific range within the given range and combinations of sub-ranges between the given ranges. Thus, a range of 1 to 5 specifically includes 1,2, 3,4, and 5, as well as sub-ranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, and so forth.

All components and elements explicitly set forth in this disclosure may be excluded from the claims. In other words, the cosmetic compositions (nanoemulsions) of the present disclosure may be free or substantially free of all components and elements specifically enumerated throughout the present disclosure.

In some cases, the cosmetic compositions of the present disclosure may be substantially free of non-incidental amounts of one or more of the ingredients or compounds described herein. A non-incidental amount of an ingredient or compound is the amount of the ingredient or compound added separately to the cosmetic composition. For example, the cosmetic composition may be substantially free of non-incidental amounts of ingredients or compounds, although such one or more ingredients or compounds may be present as part of the raw materials that are included as a blend of two or more compounds.

It is contemplated that some of the various category components may overlap. Where there may be overlap and the composition comprises two components (or the composition comprises more than two components overlapping), the overlapping compounds do not denote more than one component. For example, tocopherol can be described as both a skin active agent and a preservative. If a particular composition contains both a skin active agent and a preservative, steareth-20 will act only as a skin active agent or only as a preservative (tocopherol does not act as both a skin active agent and a preservative).

All publications and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference and set forth in its entirety herein for all purposes. In case of conflict between the present disclosure and any publication or patent application incorporated by reference herein, the present disclosure controls.

As used herein, the terms "comprising," "having," and "including" are used in their open, non-limiting sense.

The terms "a", "an" and "the" are to be understood as including the plural as well as the singular. Thus, the term "mixture thereof" also relates to "mixture thereof". Throughout the disclosure, the term "mixture thereof" is used, which follows a list of elements as shown in the following examples, wherein the letters a-F represent the elements: "one or more elements selected from the group consisting of A, B, C, D, E, F and mixtures thereof". The term "mixture thereof" does not require that the mixture include all of a, B, C, D, E, and F (although all of a, B, C, D, E, and F may be included). Rather, it represents a mixture that may contain any two or more of a, B, C, D, E, and F. In other words, it corresponds to the phrase "one or more elements selected from A, B, C, D, E, F and mixtures of any two or more of A, B, C, D, E and F"

The expression "one or more" means "at least one" and thus includes individual components as well as mixtures/combinations.

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be modified in all instances by the term "about" meaning within +/-5% of the stated number.

As used herein, the term "treating" (and grammatical variations thereof) refers to applying a composition of the present disclosure to the surface of a keratinous substrate, such as hair on the head and/or body of a user.

As used herein, the term "substantially free" means that less than about 2% by weight of a particular material is added to the composition based on the total weight of the composition. However, the composition may include less than about 1%, less than about 0.5%, less than about 0.1%, or be completely free of the specified material by weight. All components listed herein may optionally be included in or excluded from the composition/method/kit. When excluded, the composition/method/kit may be free or substantially free of components. For example, a particular composition may be free or substantially free of silicone.

Claims (20)

1. A cosmetic composition comprising:

(a) About 0.01 to about 3 weight percent retinol;

(b) From about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate;

(c) About 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate;

(d) About 0.5 to about 7 weight percent of polyglycerol-3 methyl glucose distearate;

(e) About 0.9 to about 7 weight percent sodium polyacrylate;

(f) About 0.5 to about 8 weight percent of an oil phase; and

(g) The amount of water is controlled by the amount of water,

wherein the cosmetic composition is an oil-in-water emulsion and all weight percents are based on the total weight of the cosmetic composition.

2. The cosmetic composition of claim 1, wherein the oil phase comprises a silicone.

3. The cosmetic composition of claim 1, wherein the oil phase comprises coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina blue seed oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grape seed oil, rapeseed oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, or mixtures thereof.

4. The cosmetic composition of any one of claims 1-3, wherein the oil phase comprises a fatty ester that is not polyglyceryl-3 methyl glucose distearate.

5. The cosmetic composition of claim 4 wherein said fatty ester is selected from the group consisting of isononyl isononanoate, caprylic/capric triglyceride and mixtures thereof.

6. The cosmetic composition of claim 1, further comprising:

(h) About 0.05 to about 5 weight percent of a thickener that is not sodium polyacrylate.

7. The cosmetic composition of any one of claims 1-3 having a ratio of about 1:1 to about 1:5 weight ratio of total amount of trisodium ethylenediamine disuccinate to total amount of sodium polyacrylate.

8. The cosmetic composition of any one of claims 1-3, further comprising:

(i) About 0.1 to about 10 weight percent matting agent.

9. The cosmetic composition of claim 8, wherein the matting agent comprises aluminum starch octenyl succinate.

10. The cosmetic composition of any one of claims 1-3, further comprising:

(j) About 1 to about 30 weight percent of a polyol.

11. The cosmetic composition of claim 10 wherein the polyol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, octanediol, 1,3 propanediol, glycerin, diglycerin, polyethylene glycol, and mixtures thereof.

12. The cosmetic composition of any one of claims 1-3, further comprising:

(k) About 0.05 to about 5 weight percent of a skin active agent.

13. The cosmetic composition of claim 12 wherein said active agent is selected from the group consisting of hyaluronic acid, niacinamide, lanolin, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, octanoylsalicylic acid, retinoids, retinal, retinol, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, and mixtures thereof.

14. The cosmetic composition of any one of claims 1-3, which is free of tocopherol.

15. The cosmetic composition of any one of claims 1-3, which is free of ascorbyl palmitate.

16. A cosmetic product comprising:

(I) Cosmetic composition in the form of an oil-in-water emulsion comprising:

(a) About 0.01 to about 3 weight percent retinol;

(b) From about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate;

(c) About 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate;

(d) About 0.5 to about 7 weight percent polyglycerol-3 methyl glucose distearate;

(e) About 0.9 to about 7 weight percent sodium polyacrylate;

(f) About 0.5 to about 8 weight percent of an oil phase; and

(g) Water;

wherein all weight percents are based on the total weight of the cosmetic composition, and

(II) a container containing the cosmetic composition.

17. The cosmetic product of claim 16, wherein the container does not contain an aluminum layer.

18. The cosmetic product of claim 16 or 17 wherein the composition does not phase separate and retains at least 85% by weight retinol after 8 weeks of storage at 45 ℃.

19. The cosmetic product of claim 16 or 17 wherein the composition does not yellow after 8 weeks of storage at 45 ℃.

20. A cosmetic composition consisting of:

(a) About 0.01 to about 3 weight percent retinol;

(b) From about 0.01 to about 1 weight percent tetra-di-tert-butyl hydroxyhydrocinnamate;

(c) About 0.01 to about 3 weight percent trisodium ethylenediamine disuccinate;

(d) About 0.5 to about 7 weight percent of polyglycerol-3 methyl glucose distearate;

(e) About 0.9 to about 7 weight percent sodium polyacrylate;

(f) About 0.5 to about 8 weight percent of an oil phase;

(g) Water;

(h) Optionally, from about 0.05 to about 5 weight percent of a thickener that is not sodium polyacrylate;

(i) Optionally, from about 0.1 to about 10 weight percent of a matting agent;

(j) Optionally, from about 1 to about 30 weight percent of a polyol; and

(k) Optionally, a skin active agent in an amount up to about 5% by weight,

wherein the cosmetic composition is an oil-in-water emulsion and all weight percents are based on the total weight of the cosmetic composition.