CN115777700A - Suspending agent containing metribuzin and topramezone and preparation method thereof - Google Patents
Suspending agent containing metribuzin and topramezone and preparation method thereof Download PDFInfo
- Publication number
- CN115777700A CN115777700A CN202211520970.5A CN202211520970A CN115777700A CN 115777700 A CN115777700 A CN 115777700A CN 202211520970 A CN202211520970 A CN 202211520970A CN 115777700 A CN115777700 A CN 115777700A
- Authority
- CN
- China
- Prior art keywords
- wetting dispersant
- metribuzin
- agent
- topramezone
- wetting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005583 Metribuzin Substances 0.000 title claims abstract description 56
- FOXFZRUHNHCZPX-UHFFFAOYSA-N metribuzin Chemical compound CSC1=NN=C(C(C)(C)C)C(=O)N1N FOXFZRUHNHCZPX-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000000375 suspending agent Substances 0.000 title claims abstract description 34
- IYMLUHWAJFXAQP-UHFFFAOYSA-N topramezone Chemical compound CC1=C(C(=O)C2=C(N(C)N=C2)O)C=CC(S(C)(=O)=O)=C1C1=NOCC1 IYMLUHWAJFXAQP-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims description 15
- 239000002270 dispersing agent Substances 0.000 claims abstract description 63
- 238000009736 wetting Methods 0.000 claims abstract description 63
- 239000002562 thickening agent Substances 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000002518 antifoaming agent Substances 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 5
- 229920001577 copolymer Polymers 0.000 claims description 30
- 159000000000 sodium salts Chemical class 0.000 claims description 23
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 20
- 229920000570 polyether Polymers 0.000 claims description 20
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- -1 sulfonate ammonium salt Chemical class 0.000 claims description 15
- 239000000080 wetting agent Substances 0.000 claims description 15
- CASLETQIYIQFTQ-UHFFFAOYSA-N 3-[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylsulfonyl]-5,5-dimethyl-4h-1,2-oxazole Chemical compound CN1N=C(C(F)(F)F)C(CS(=O)(=O)C=2CC(C)(C)ON=2)=C1OC(F)F CASLETQIYIQFTQ-UHFFFAOYSA-N 0.000 claims description 14
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000005605 Pyraflufen-ethyl Substances 0.000 claims description 13
- 150000003863 ammonium salts Chemical class 0.000 claims description 12
- 229930003836 cresol Natural products 0.000 claims description 11
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 10
- 229920001732 Lignosulfonate Polymers 0.000 claims description 10
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 10
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 10
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 10
- APTZNLHMIGJTEW-UHFFFAOYSA-N pyraflufen-ethyl Chemical group C1=C(Cl)C(OCC(=O)OCC)=CC(C=2C(=C(OC(F)F)N(C)N=2)Cl)=C1F APTZNLHMIGJTEW-UHFFFAOYSA-N 0.000 claims description 10
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 10
- 239000000230 xanthan gum Substances 0.000 claims description 10
- 229920001285 xanthan gum Polymers 0.000 claims description 10
- 229940082509 xanthan gum Drugs 0.000 claims description 10
- 235000010493 xanthan gum Nutrition 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000006229 carbon black Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 241000227425 Pieris rapae crucivora Species 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 5
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- TVFWYUWNQVRQRG-UHFFFAOYSA-N 2,3,4-tris(2-phenylethenyl)phenol Chemical compound C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 TVFWYUWNQVRQRG-UHFFFAOYSA-N 0.000 claims description 4
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 claims description 4
- PQUCIEFHOVEZAU-UHFFFAOYSA-N Diammonium sulfite Chemical compound [NH4+].[NH4+].[O-]S([O-])=O PQUCIEFHOVEZAU-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229920000147 Styrene maleic anhydride Polymers 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229920002866 paraformaldehyde Polymers 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000004546 suspension concentrate Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 14
- 239000012752 auxiliary agent Substances 0.000 abstract description 7
- 238000005054 agglomeration Methods 0.000 abstract description 4
- 230000002776 aggregation Effects 0.000 abstract description 4
- 230000002528 anti-freeze Effects 0.000 abstract description 4
- 229910001566 austenite Inorganic materials 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 230000002349 favourable effect Effects 0.000 abstract description 3
- 230000008859 change Effects 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 14
- 238000011282 treatment Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- 239000013078 crystal Substances 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- 244000068988 Glycine max Species 0.000 description 7
- 235000010469 Glycine max Nutrition 0.000 description 7
- 235000013339 cereals Nutrition 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 230000002363 herbicidal effect Effects 0.000 description 6
- 239000004009 herbicide Substances 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 238000010008 shearing Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000013329 compounding Methods 0.000 description 5
- 238000005338 heat storage Methods 0.000 description 5
- 239000002689 soil Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000006303 photolysis reaction Methods 0.000 description 3
- 230000015843 photosynthesis, light reaction Effects 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 231100000674 Phytotoxicity Toxicity 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 238000009333 weeding Methods 0.000 description 2
- 238000004260 weight control Methods 0.000 description 2
- BZOVBIIWPDQIHF-UHFFFAOYSA-N 3-hydroxy-2-methylbenzenesulfonic acid Chemical class CC1=C(O)C=CC=C1S(O)(=O)=O BZOVBIIWPDQIHF-UHFFFAOYSA-N 0.000 description 1
- 241000219318 Amaranthus Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000008564 Boehmeria nivea Species 0.000 description 1
- 241000611157 Brachiaria Species 0.000 description 1
- 241000209200 Bromus Species 0.000 description 1
- 208000003643 Callosities Diseases 0.000 description 1
- 241000219312 Chenopodium Species 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000009849 Cucumis sativus Nutrition 0.000 description 1
- 235000017896 Digitaria Nutrition 0.000 description 1
- 241001303487 Digitaria <clam> Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 241000209082 Lolium Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 240000001140 Mimosa pudica Species 0.000 description 1
- 235000016462 Mimosa pudica Nutrition 0.000 description 1
- ROKXSHQOEYMQJR-UHFFFAOYSA-N N.C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 Chemical compound N.C=1C=CC=CC=1C=CC1=C(C=CC=2C=CC=CC=2)C(O)=CC=C1C=CC1=CC=CC=C1 ROKXSHQOEYMQJR-UHFFFAOYSA-N 0.000 description 1
- BOLQUPOXTWHXIX-UHFFFAOYSA-N OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 BOLQUPOXTWHXIX-UHFFFAOYSA-N 0.000 description 1
- 241000745991 Phalaris Species 0.000 description 1
- RRKHIAYNPVQKEF-UHFFFAOYSA-N Pyriftalid Chemical compound COC1=CC(OC)=NC(SC=2C=3C(=O)OC(C)C=3C=CC=2)=N1 RRKHIAYNPVQKEF-UHFFFAOYSA-N 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241000207763 Solanum Species 0.000 description 1
- 235000002634 Solanum Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000005592 Veronica officinalis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 238000010296 bead milling Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000442 meristematic effect Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 238000007517 polishing process Methods 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- YXIIPOGUBVYZIW-UHFFFAOYSA-N pyraflufen Chemical compound ClC1=C(OC(F)F)N(C)N=C1C1=CC(OCC(O)=O)=C(Cl)C=C1F YXIIPOGUBVYZIW-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a suspending agent containing metribuzin and topramezone, which comprises the following components in percentage by mass: 25 to 60 percent of active component; 3 to 11 percent of wetting dispersant; 0.2 to 5.0 percent of thickening agent; 0.2 to 3.0 percent of defoaming agent; 3 to 20 percent of antifreeze; 0.1 to 2.0 percent of preservative; the balance of water; the active ingredients comprise metribuzin and topramezone; the mass ratio of metribuzin to topramezone is (1-5): 1. according to the invention, by selecting the auxiliary agent preferably, the stability of the product is improved, the problem of austenite curing is solved, the product can tolerate the high-low temperature range of-15 ℃ to 65 ℃, the influence of environmental change in the transportation process is effectively solved, and the product quality problems of agglomeration, creaming, particle size growth and bleeding are avoided. Can resist different water qualities such as C water, D water, 3WHO water and the like, meets the use requirements of different countries and regions, and is favorable for large-scale popularization and application.
Description
Technical Field
The invention relates to the technical field of pesticide preparations, and particularly relates to a suspending agent containing metribuzin and topramezone and a preparation method thereof.
Background
Metribuzin (Metribuzin), chemical name: 4-amino-6-tert-butyl-4,5-dihydro-3-methylthio-1,2,4-triazine-5 (4H) -ketone belongs to a systemic selective triazophenone herbicide, a medicament is absorbed by the root system of weeds and is conducted towards the upper part along with transpiration, the herbicide activity is exerted by mainly inhibiting the photosynthesis of sensitive plants, the germination and emergence of sensitive weeds are not affected after application, leaves are faded after emergence, and finally nutrition is exhausted and died. The herbicide composition is mainly used for preventing and killing broadleaf weeds and gramineous weeds in dry crops such as soybeans, potatoes, tomatoes, sugarcanes, corns, cucumbers and the like.
Pyraflufen-ethyl (pyroxasulfone), chemical name: 3- (((5- (difluoromethoxy) -1-methyl-3- (trifluoromethyl) -1H-pyrazol-4-yl) methyl) sulfonyl) -5,5-dimethyl-4,5-dihydroisoxazole, which belongs to a novel isoxazole herbicide, exerts drug effects by inhibiting ultralong-chain fatty acid elongation synthase (VLCFAE), is absorbed by young roots and young buds of weeds after application, inhibits early growth of seedlings, and destroys meristematic tissues and coleoptiles. The herbicide composition is widely applied to crops such as wheat, corn, soybean and peanut, and can effectively prevent and kill weeds such as bromus, ryegrass, phalaris, digitaria, brachiaria, solanum, veronica, chenopodium, amaranthus, ramie and porcine seedling.
At present, the single application of metribuzin or pyraflufen-ethyl for agricultural weed control has the defects of narrow weeding range, poor control effect, large application dosage, easy generation of drug resistance or drug resistance, more application times, environmental pollution and the like, and researches show that the metribuzin and the pyraflufen-ethyl have a synergistic effect, and the composition of the metribuzin and the pyraflufen-ethyl has the effects of expanding the weeding spectrum and delaying the resistance of weeds.
However, the solubility of metribuzin in water is 10.7g/L (20 ℃), the industry is well known that in the development of a suspending agent, a raw pesticide with the water solubility of more than 100mg/L has a typical oxgall curing problem, namely small crystal grains are dissolved continuously and disappear due to different particle sizes and different dissolution speeds; the dissolution speed of the large crystal grains is relatively slow, the medium of the large crystal grains is supersaturated solution, and molecules in the solution crystallize on the large crystal grains, so that the phenomenon that the large crystal grains are larger and larger is caused, and the suspending agent does not meet the national standard or the FAO standard and cannot be applied in a marketable manner.
At present, no product registration of metribuzin and topramezone suspending agents exists in various countries, the metribuzin and topramezone containing suspending agents existing in the market have unstable product quality and obvious austenite curing phenomenon, the phenomenon of obvious particle size growth can occur after the suspending agents are stored at normal temperature, the suspending agents are easily influenced by environmental changes in the marine transportation process, the phenomena of caking, creaming, particle size growth, water precipitation and the like are easily caused at high temperature, and the drug effect is seriously influenced due to the crystallization risk at low temperature. In the using process, the influence of different water qualities is large, for example, the product is not tolerant to 3WHO water, and the use and popularization of the product are not facilitated.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a suspending agent containing metribuzin and pyroxasulfone and a preparation method thereof, wherein the stability of the product is improved by selecting an auxiliary agent.
The invention provides a suspending agent containing metribuzin and pyroxasulfone, which comprises the following components in percentage by mass:
the active ingredients comprise metribuzin and topramezone;
the mass ratio of metribuzin to pyroxasulfone is (1-5): 1.
the invention takes metribuzin and pyroxasulfone as active ingredients, and the mass ratio of the metribuzin to the pyroxasulfone is (1-5): 1 has synergistic effect. The mass ratio of the two is more preferably (2 to 4): 1, more preferably (2.5 to 4): 1, including but not limited to 2.5.
The total mass content of metribuzin and topramezone is preferably 25-60%, more preferably 40-60%, even more preferably 45-60%, including but not limited to 45%, 46%, 48%, 50% or 60%.
Metribuzin: the pure product is white crystalline solid. Molecular weight 214.29, solubility in water 10.7g/L (20 ℃), melting point 125.5 ℃, kowLogP =1.6 (25 ℃), density 1.26g/L. It is stable to ultraviolet light, stable in acid and alkali at 20 deg.C, and fast photolysis in water.
Sulfone pyraflufen-ethyl: the appearance was a white solid. Molecular weight 391.32, solubility in water 3.49mg/L (20 ℃), melting point 130.7 ℃, kowLogP =2.39 (pH =7, 20 ℃), density 1.598g/L. At 25 ℃, the sulphone pyraflufen-ethyl is difficult to hydrolyze under the conditions of pH 4, 7 and 9, and the half-life periods are respectively 138.6, 115.5 and 115.5d. The waterlogging anaerobic condition is more favorable for the degradation of the pyraflufen-ethyl in the soil; the photolysis type of the xaflufen in the soil surface belongs to the photolysis difficulty, and the degradation half-life period is 231h. The material is easy to photolyze in organic solvents of ethyl acetate and acetonitrile, is difficult to photolyze in acetone, and has degradation half-life periods of 1.43, 2.38 and 21.66h respectively.
From the properties of the two, the metribuzin has high water solubility, is easy to generate an austenite curing phenomenon, causes the particle size of a product to grow rapidly, and has the risks of heat storage creaming, agglomeration and low-temperature crystal precipitation, so that the two components are mixed to prepare the water suspending agent with certain difficulty, and the separation, agglomeration and layering of the original drug particles in a suspension dispersion system are easy to occur. According to the invention, a large amount of screening work is carried out on an auxiliary agent system, and a system with the best matching degree among all components is finally obtained, particularly the screening and combination of the wetting dispersant and the thickening agent are carried out, so that the processing difficulty of the preparation formulation is greatly reduced, the stability of the preparation formulation is improved, the preparation formulation has the advantages of good dispersibility and high suspension rate, and the problems of sample storage creaming, flocculation, large particle size, low-temperature precipitation and the like are effectively solved.
The wetting dispersant of the suspending agent containing metribuzin and pyriftalid is preferably two or more of epoxypropane-ethylene oxide block polyether, lignosulfonate, a naphthalenesulfonate formaldehyde condensate, styrene acrylic acid copolymer sodium salt, styrene acrylic acid copolymer ammonium salt, styrene maleic anhydride copolymer sodium salt, tristyrylphenol polyoxyethylene ether sulfate ammonium salt, maleated rosin block polyether sulfonate ammonium salt, fatty alcohol polyoxyethylene ether phosphate, castor oil polyoxyethylene ether phosphate, cresol sodium sulfonate and alkylaryl phenol polyoxyethylene polyoxypropylene ether. More preferably, the wetting and dispersing agent is selected from two or three of the above compounds for compounding.
The mass content of the wetting dispersant is preferably 3% to 11%, more preferably 5% to 7%, including but not limited to 5%, 6% or 7%.
Preferably, the wetting dispersant comprises a first wetting dispersant and a second wetting dispersant.
The first wetting dispersant is preferably any one of a styrene acrylic acid copolymer sodium salt, a styrene acrylic acid copolymer ammonium salt and a styrene maleic anhydride copolymer sodium salt.
The second wetting and dispersing agent is preferably any one of maleic rosin block polyether ammonium sulfonate, naphthalene sulfonate formaldehyde condensate, lignosulfonate and cresol sodium sulfonate.
The mass ratio of the first wetting dispersant to the second wetting dispersant is preferably (1-5): (1-5).
In some embodiments of the invention, the wetting and dispersing agent is selected from naphthalene sulfonate formaldehyde condensate and styrene acrylic acid copolymer sodium salt. The mass ratio of the two is preferably 1:2. Optionally, the mass content of the naphthalene sulfonate formaldehyde condensate is 1%, and the mass content of the styrene acrylic acid copolymer sodium salt is 2%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of ammonium salts of styrene acrylic acid copolymers and ammonium salts of maleated rosin block polyether sulfonates. The mass ratio of the two is preferably 2:3. Optionally, the mass content of the styrene acrylic acid copolymer ammonium salt is 2%, and the mass content of the maleated rosin block polyether sulfonic acid ammonium salt is 3%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of sodium salts of styrene acrylic acid copolymers and lignosulfonates. The mass ratio of the two is preferably 6:2. Optionally, the mass content of the styrene acrylic acid copolymer sodium salt is 6%, and the mass content of the lignosulfonate is 2%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of sodium salts of styrene acrylic acid copolymers and sodium salts of cresol sulfonic acid. The mass ratio of the two is preferably 2:4. Optionally, the mass content of the styrene acrylic acid copolymer sodium salt is 2%, and the mass content of the cresol sulfonic acid sodium salt is 4%.
In some other preferable embodiments of the present invention, the wetting dispersant includes a third wetting dispersant, a fourth wetting dispersant and a fifth wetting dispersant.
The third wetting and dispersing agent is preferably any one of a sodium salt of a styrene acrylic acid copolymer and an ammonium salt of a styrene acrylic acid copolymer.
The fourth wetting and dispersing agent is preferably any one of triphenylethylene phenol polyoxyethylene ether sulfate ammonium salt, naphthalene sulfonate formaldehyde condensate and lignosulfonate.
The fifth wetting dispersant is preferably any one of propylene oxide-ethylene oxide block polyether, cresol sodium sulfonate and maleated rosin block polyether ammonium sulfonate.
Further preferably, the third wetting dispersant is selected from sodium styrene acrylic acid copolymer, the fourth wetting dispersant is selected from naphthalene sulfonate formaldehyde condensate, and the fifth wetting dispersant is selected from sodium cresol sulfonate.
The mass ratio of the third wetting dispersant to the fourth wetting dispersant to the fifth wetting dispersant is 1: (1-5): (1 to 5), more preferably 1: (1-3): (1 to 3), more preferably 1.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of sodium salt of styrene acrylic acid copolymer, ammonium tristyrylphenol polyoxyethylene ether sulfate salt, and propylene oxide-ethylene oxide block polyether. The mass ratio of the three is preferably 3. Optionally, the mass content of the styrene acrylic acid copolymer sodium salt is preferably 3%, the mass content of the tristyrylphenol polyoxyethylene ether sulfate ammonium salt is 4%, and the mass content of the propylene oxide-ethylene oxide block polyether is 4%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of styrene acrylic acid copolymer sodium salt, naphthalene sulfonate formaldehyde condensate, and cresol sulfonate sodium salt. The mass ratio of the three is preferably 1. Optionally, the mass content of the styrene acrylic acid copolymer sodium salt is 2%, the mass content of the naphthalenesulfonate formaldehyde condensate is 2%, and the mass content of the cresol sulfonic acid sodium salt is 2%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of ammonium salts of styrene acrylic acid copolymers, naphthalene sulfonate formaldehyde condensates and ammonium salts of maleated rosin block polyether sulfonates. The mass ratio of the three is preferably 2. Optionally, the mass content of the styrene acrylic acid copolymer ammonium salt is 2%, the mass content of the naphthalene sulfonate formaldehyde condensate is 2%, and the mass content of the maleated rosin block polyether sulfonic acid ammonium salt is 3%.
In some embodiments of the invention, the wetting and dispersing agent is selected from the group consisting of sodium styrene acrylic acid copolymer, sodium cresol sulfonate, and lignosulfonate. The mass ratio of the three is preferably 3. Optionally, the mass content of the styrene acrylic acid copolymer sodium salt is 3%, the mass content of the cresol sodium sulfonate is 2%, and the mass content of the lignosulfonate is 2%.
Test results show that the two-component or three-component compounded wetting dispersant can improve the stability of products and improve the commodity of the products.
The mass content of the thickener is preferably 0.2% to 5.0%, more preferably 0.5% to 2.0%, including but not limited to 0.65% or 1.15%.
Preferably, the thickener is selected from one or more of common white carbon black, magnesium aluminum silicate, methyl cellulose, bentonite, xanthan gum and sodium polyacrylate.
Preferably, the thickening agent comprises a first thickening agent and a second thickening agent.
The first thickener is preferably xanthan gum.
The second thickener is preferably any one of magnesium aluminum silicate and common white carbon black.
Further preferably, the first thickener is selected from xanthan gum; the second thickening agent is selected from common white carbon black.
The mass ratio of the first thickener to the second thickener is preferably (0.05 to 0.4): 1, more preferably (0.05-0.3) 1, including but not limited to 0.075.
In some embodiments of the invention, the first thickener is present in an amount of 0.15% by mass and the second thickener is present in an amount of 0.5% by mass.
In some embodiments of the invention, the first thickener is present in an amount of 0.15% by mass and the second thickener is present in an amount of 2% by mass.
In some embodiments of the invention, the first thickener is present in an amount of 0.15% by mass and the second thickener is present in an amount of 1% by mass.
In some embodiments of the present invention, the first thickener is 0.08% by mass and the second thickener is 0.5% by mass.
In some embodiments of the invention, the thickener is selected from xanthan gum and white carbon black. The mass content of the xanthan gum is preferably 0.15%, and the mass content of the common white carbon black is preferably 0.5%.
In some embodiments of the invention, the thickening agent is selected from xanthan gum and magnesium aluminum silicate. The mass content of the xanthan gum is preferably 0.08%, and the mass content of the magnesium aluminum silicate is preferably 0.5%.
By adopting the composite thickening agent, the invention further improves the stability of the product over time and avoids the occurrence of water separation and stratification.
The mass content of the defoaming agent is preferably 0.2% to 3.0%, more preferably 0.2% to 1%, and even more preferably 0.2% to 1%, including but not limited to 0.2%, 0.5%, or 1%.
The defoaming agent is preferably one or more of a polyether defoaming agent, a silicone defoaming agent and a polyether modified polysiloxane defoaming agent. More preferably a silicone defoamer.
In some embodiments of the invention, the defoamer is selected from silicone defoamers. The mass content of the silicone defoaming agent is preferably 0.2%.
The mass content of the antifreeze is preferably 3% to 20%, more preferably 4% to 10%, including but not limited to 4%, 5% or 10%.
The antifreeze is preferably one or more of urea, potassium chloride, ethylene glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol and sodium chloride. More preferably glycerol or ethylene glycol.
In some embodiments of the invention, the antifreeze agent is selected from ethylene glycol. The mass content of the ethylene glycol is preferably 5%.
The preservative is preferably present in an amount of 0.1% to 2.0%, more preferably 0.1% to 0.3%, including but not limited to 0.1%, 0.2% or 0.3% by mass.
The preservative is preferably one or more of cason, paraformaldehyde and sodium benzoate. More preferably, cason.
In some embodiments of the invention, the preservative is selected from the group consisting of cason. The content of the cason by mass is preferably 0.1%.
The invention provides a preparation method of the suspending agent containing metribuzin and topramezone, which comprises the following steps:
s1) mixing water, a wetting dispersant, a preservative and a first defoaming agent to obtain a first mixed system;
s2) mixing and grinding the first mixed system, the thickening agent, the second defoaming agent, the antifreezing agent, metribuzin and the xaflufen to obtain the suspending agent containing metribuzin and xaflufen.
Preferably, the preparation method comprises the following steps:
s11) mixing water, a wetting dispersant, a preservative and a first defoaming agent to obtain a first mixed system;
s22) mixing the first mixing system with the thickening agent, the second defoaming agent, the antifreezing agent, metribuzin and the pyraflufen-ethyl under a high-speed shearing condition, shearing and grinding to obtain the suspending agent containing metribuzin and the pyraflufen-ethyl.
In the invention, the defoaming agent is added twice and marked as a first defoaming agent and a second defoaming agent, so that foams generated in different stages in the preparation process can be effectively eliminated.
The high-speed shearing speed is preferably 1000-10000r/min.
The shearing time is preferably 10 to 30min.
The method of polishing in the present invention is not particularly limited, and may be a method known to those skilled in the art. Milling can be carried out, for example, under a zirconia bead milling medium. After grinding, the particle size D90 is less than 7 μm as measured by a laser particle size distribution analyzer.
Compared with the prior art, the invention provides a suspending agent containing metribuzin and pyroxasulfone, which comprises the following components in percentage by mass: 25 to 60 percent of active component; 3 to 11 percent of wetting dispersant; 0.2 to 5.0 percent of thickening agent; 0.2 to 3.0 percent of defoaming agent; 3 to 20 percent of antifreeze; 0.1 to 2.0 percent of preservative; the balance of water; the active ingredients comprise metribuzin and pyroxasulfone; the mass ratio of metribuzin to pyroxasulfone is (1-5): 1. according to the invention, by selecting the auxiliary agent preferably, the stability of the product is improved, the problem of austenite curing is solved, the product can tolerate the high-low temperature range of-15 ℃ to 65 ℃, the influence of environmental change in the transportation process is effectively solved, and the product quality problems of agglomeration, creaming, large particle size and water precipitation are avoided. Can resist different water qualities such as C water, D water, 3WHO water and the like, meets the use requirements of different countries and regions, and is favorable for large-scale popularization and application. The content of metribuzin and sulfone pyraflufen can reach 60%, and the synergistic effect is beneficial to reducing the dosage and the application frequency.
Detailed Description
In order to further illustrate the invention, the suspending agent containing metribuzin and pyroxasulfone and the preparation method thereof provided by the invention are described in detail by combining the examples.
Unless otherwise specified, the following percentages are by weight.
Examples 1 to 8
The water suspension containing metribuzin and topramezone is prepared according to the mixture ratio in the table 1, and the preparation process comprises the following steps:
adding water, a wetting dispersant and a preservative into a reaction kettle, and fully mixing and uniformly dispersing; adding the thickening agent, the defoaming agent, the antifreezing agent, metribuzin and the topramezone into the reaction kettle under the high-speed shearing state at the speed of 1000-10000r/min, shearing for 10-30 minutes, and then grinding until the particle size D90 of the mixture is less than 7 mu m to obtain the water suspending agent containing metribuzin and topramezone.
Comparative examples 1 to 6
The water suspending agent containing metribuzin and pyraflufen-ethyl is prepared according to the mixture ratio in the table 1, and the preparation process is the same as that of the embodiments 1-8.
TABLE 1 EXAMPLES 1 TO 8, COMPARATIVE EXAMPLES 1 TO 4 Components AND compounding ratio
The performance of the aqueous suspensions prepared in the above examples and comparative examples was measured, and the results are shown in Table 2 below. Wherein, the suspension rate is detected according to a GB/T14825-2006 pesticide suspension rate measuring method, and the spontaneous dispersibility in water is detected according to a CIPAC MT160 measuring method.
TABLE 2 aqueous suspension product performance prepared by compounding metribuzin and xaflufen-p-ethyl
As can be seen from Table 2, comparative example 5 cannot be normally sanded for discharging, comparative examples 1,2, 3, 4 and 6 are poor in quality after thermal storage, cannot tolerate the high and low temperature range of-15 ℃ to 65 ℃, are stored for 3 days at-15 ℃, and have the phenomenon of massive water separation or loss of fluidity after being converted to normal temperature; after the sample is stored for 3 days at 65 ℃, the sample is turned to normal temperature, the phenomena of solidification, poor fluidity and the like respectively occur, the wet sieve test is unqualified, and the phenomenon of crystal precipitation exists in the microscope observation. The grain size is serious when the particles are stored and transferred at 54 ℃ and the particle size is big at normal temperature, and the suspension rate is greatly reduced. The examples 1,2, 6, 7 and 8 were slightly inferior in quality after heat storage, the particle size was increased, the heat storage suspension rate was decreased, and the examples 6 and 8 also had a certain phenomenon of water separation. The mass of the samples 3, 4 and 5 is slightly changed after heat storage, and the suspension rate is slightly high; and example 4 is good before and after heat storage, and is worth paying attention to that the grain diameter of the product does not grow but becomes smaller, so that the risk of crystal growth and precipitation is effectively avoided, and the dispersion stability in different water qualities is good. It follows that the preferred adjuvants play a critical role in product quality.
Field test
The experiment is arranged in a soybean field suburbed in the longevity city of the Weifang city in Shandong province, the topography is flat, the land is flat, irrigation and drainage facilities are complete, the field management level is consistent, and the fertility is uniform and medium. The total of 5 treatments are respectively as follows: treatment 1: spraying clear water, and blank control; and (3) treatment 2: suspending agents of examples 4, 7 and comparative example 1; and (3) treatment: 480g/L of metribuzin suspending agent; and (4) treatment: 40% of a suspension agent of the sulfone pyraflufen-ethyl.
Wherein, the treatment 2 is carried out the soil spraying treatment according to the effective component dosage of 360 g/hectare, the treatment 3 is carried out the soil spraying treatment according to the effective component dosage of 648 g/hectare, and the treatment 4 is carried out the soil spraying treatment according to the effective component dosage of 180 g/hectare.
The pesticide is applied for 1 time by a worker-farm-16 knapsack hand sprayer, and the pesticide liquid is prepared by adding 450kg of water into the pesticide liquid per hectare and is sprayed uniformly. The weather during the test was good and the daily average temperature was 18-25 ℃. No rain is present on the day of application, and no rain is present within 10 days after application.
The fresh weight control effect of each treatment on weeds and the safety of each treatment on soybeans were investigated 30 days after the application of the herbicide. The results are shown in Table 4.
The method for investigating the fresh weight control effect of the weeds comprises the following steps:
at 30 days after application, 4 points of 0.25m per point are randomly selected from each cell 2 And (4) removing annual broad-leaved weeds, classifying and weighing fresh weight of the weeds, and calculating the control effect of the fresh weight of the weeds.
The control effect was calculated according to formula (a) and the results are shown in table 4.
TABLE 3 application rates for the respective experimental groups
TABLE 4 pharmacodynamic test data
The test results in the table show that the compounding of metribuzin and topramezone has good control effect on annual weeds in soybean fields, and the control effect of the example 4 using the preferred auxiliary agent is obviously better than that of the example 7, the comparative example 1 and the contrast agent, so that the synergistic effect is shown. As can be seen from the comparison of the drug effects of the examples and the comparative examples, the selection of the auxiliary agent has an important influence on the exertion of the effective components, and improper selection of the auxiliary agent can influence the compounding effect of the metribuzin and the topramezone.
In addition, according to the whole-course observation of field experiments, the soybean field grows well within the range of the experimental dosage, and no phytotoxicity phenomenon appears, which indicates that the compound pesticide has no phytotoxicity to the soybean field.
The experiments show that the pesticide composition provided by the invention can meet the requirements of different water qualities, can tolerate the high and low temperature range of-15 ℃ to 65 ℃, has higher stability, and is beneficial to large-scale popularization and use of products.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (10)
1. A suspending agent containing metribuzin and pyroxasulfone comprises the following components in percentage by mass:
the active ingredients comprise metribuzin and pyroxasulfone;
the mass ratio of metribuzin to topramezone is (1-5): 1.
2. the suspending agent containing metribuzin and topramezone according to claim 1, wherein the wetting and dispersing agent is selected from two or more of propylene oxide-ethylene oxide block polyether, lignosulfonate, naphthalenesulfonate formaldehyde condensate, styrene acrylic acid copolymer sodium salt, styrene acrylic acid copolymer ammonium salt, styrene maleic anhydride copolymer sodium salt, tristyrylphenol polyoxyethylene ether sulfate ammonium salt, maleated rosin block polyether sulfonate ammonium salt, fatty alcohol polyoxyethylene ether phosphate ester, castor oil polyoxyethylene ether phosphate ester, cresol sulfonate sodium salt, and alkylaryl phenol polyoxyethylene polyoxypropylene ether.
3. The suspending agent containing metribuzin and topramezone according to claim 2, wherein the wetting dispersant comprises a first wetting dispersant and a second wetting dispersant;
the first wetting dispersant is selected from any one of styrene acrylic acid copolymer sodium salt, styrene acrylic acid copolymer ammonium salt and styrene maleic anhydride copolymer sodium salt;
the second wetting and dispersing agent is selected from any one of maleic rosin block polyether ammonium sulfonate, naphthalene sulfonate formaldehyde condensate, lignosulfonate and cresol sodium sulfonate;
the mass ratio of the first wetting dispersant to the second wetting dispersant is (1-5): (1-5).
4. The suspending agent containing metribuzin and topramezone according to claim 2, wherein the wetting dispersant comprises a third wetting dispersant, a fourth wetting dispersant and a fifth wetting dispersant;
the third wetting dispersant is selected from any one of styrene acrylic acid copolymer sodium salt and styrene acrylic acid copolymer ammonium salt;
the fourth wetting and dispersing agent is any one selected from tristyrylphenol polyoxyethylene ether sulfate ammonium salt, a naphthalene sulfonate formaldehyde condensate and lignosulfonate;
the fifth wetting dispersant is selected from any one of propylene oxide-ethylene oxide block polyether, cresol sodium sulfonate and maleated rosin block polyether ammonium sulfonate;
the mass ratio of the third wetting dispersant to the fourth wetting dispersant to the fifth wetting dispersant is 1: (1-5): (1-5).
5. The suspending agent containing metribuzin and topramezone according to claim 4, wherein the third wetting dispersant is selected from a styrene acrylic acid copolymer sodium salt, the fourth wetting dispersant is selected from a naphthalene sulfonate formaldehyde condensate, and the fifth wetting dispersant is selected from a cresol sulfonate sodium salt;
the mass ratio of the third wetting dispersant to the fourth wetting dispersant to the fifth wetting dispersant is 1: (1-3): (1-3).
6. The suspending agent containing metribuzin and pyraflufen-ethyl according to claim 1, wherein the thickening agent is selected from one or more of white carbon black, magnesium aluminum silicate, methyl cellulose, bentonite, xanthan gum and sodium polyacrylate.
7. The suspending agent containing metribuzin and pyroxasulfone according to claim 6, wherein the thickening agent comprises a first thickening agent and a second thickening agent;
the first thickener is selected from xanthan gum;
the second thickening agent is selected from any one of magnesium aluminum silicate and common white carbon black;
the mass ratio of the first thickening agent to the second thickening agent is (0.05-0.4): 1.
8. the suspending agent containing metribuzin and topramezone according to claim 7, characterized in that the first thickening agent is selected from xanthan gum;
the second thickening agent is selected from common white carbon black;
the mass ratio of the first thickener to the second thickener is 0.3.
9. The suspending agent containing metribuzin and pyraflufen-ethyl according to claim 1, wherein the antifoaming agent is selected from one or more of a polyether antifoaming agent, a silicone antifoaming agent and a polyether modified polysiloxane antifoaming agent;
the antifreezing agent is selected from one or more of urea, potassium chloride, ethylene glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol and sodium chloride;
the preservative is selected from one or more of cason, paraformaldehyde and sodium benzoate.
10. A process for the preparation of a suspension concentrate containing metribuzin and topramezone as claimed in any one of claims 1 to 9, comprising the steps of:
s1) mixing water, a wetting dispersant, a preservative and a first defoaming agent to obtain a first mixed system;
s2) mixing and grinding the first mixed system, the thickening agent, the second defoaming agent, the antifreezing agent, metribuzin and the xaflufen to obtain the suspending agent containing metribuzin and xaflufen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211520970.5A CN115777700A (en) | 2022-11-30 | 2022-11-30 | Suspending agent containing metribuzin and topramezone and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211520970.5A CN115777700A (en) | 2022-11-30 | 2022-11-30 | Suspending agent containing metribuzin and topramezone and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115777700A true CN115777700A (en) | 2023-03-14 |
Family
ID=85443769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211520970.5A Pending CN115777700A (en) | 2022-11-30 | 2022-11-30 | Suspending agent containing metribuzin and topramezone and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115777700A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016125188A1 (en) * | 2015-02-03 | 2016-08-11 | Gsp Crop Science Pvt. Ltd. | Title: synergistic herbicidal composition of pendimethalin and metribuzin |
| CN106614630A (en) * | 2016-09-18 | 2017-05-10 | 辽宁海佳农化有限公司 | Weedicide and preparation method of weedicide |
| CN113632798A (en) * | 2021-09-23 | 2021-11-12 | 山东潍坊润丰化工股份有限公司 | Composition containing pyraflufen-ethyl and cloransulam-methyl and application thereof |
| CN114642212A (en) * | 2022-04-20 | 2022-06-21 | 山东潍坊润丰化工股份有限公司 | Suspending agent containing terbuthylazine and pyraflufen-ethyl and preparation method thereof |
| CN114651823A (en) * | 2020-12-23 | 2022-06-24 | 山东潍坊润丰化工股份有限公司 | Suspending agent of pyraflufen-ethyl and cloransulam-methyl, and preparation method and application thereof |
| CN115363040A (en) * | 2022-08-31 | 2022-11-22 | 山东润博生物科技有限公司 | Suspending agent containing topramezone and amicarbazone and preparation method thereof |
-
2022
- 2022-11-30 CN CN202211520970.5A patent/CN115777700A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016125188A1 (en) * | 2015-02-03 | 2016-08-11 | Gsp Crop Science Pvt. Ltd. | Title: synergistic herbicidal composition of pendimethalin and metribuzin |
| CN106614630A (en) * | 2016-09-18 | 2017-05-10 | 辽宁海佳农化有限公司 | Weedicide and preparation method of weedicide |
| CN114651823A (en) * | 2020-12-23 | 2022-06-24 | 山东潍坊润丰化工股份有限公司 | Suspending agent of pyraflufen-ethyl and cloransulam-methyl, and preparation method and application thereof |
| CN113632798A (en) * | 2021-09-23 | 2021-11-12 | 山东潍坊润丰化工股份有限公司 | Composition containing pyraflufen-ethyl and cloransulam-methyl and application thereof |
| CN114642212A (en) * | 2022-04-20 | 2022-06-21 | 山东潍坊润丰化工股份有限公司 | Suspending agent containing terbuthylazine and pyraflufen-ethyl and preparation method thereof |
| CN115363040A (en) * | 2022-08-31 | 2022-11-22 | 山东润博生物科技有限公司 | Suspending agent containing topramezone and amicarbazone and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101653117B (en) | Rice field herbicide composition containing cyhalofop butyl | |
| CN114642212B (en) | Suspending agent containing terbuthylazine and fenpyrad and preparation method thereof | |
| BR112018076992B1 (en) | PLANT GROWTH REGULATORY COMPOSITION | |
| CN108378051B (en) | Penoxsulam water suspending agent | |
| CN106614617A (en) | Water dispersion granule containing flumetralin and uniconazole | |
| WO2003090533A1 (en) | Plant growth regulating composition for stress- resistance and promoting growth | |
| CN112841198A (en) | Herbicidal compositions comprising benzyl pyrimidinecarboxylates and microtubule assembly/VLCFA inhibitors and uses thereof | |
| CN114503995B (en) | Dispersible oil suspending agent containing atrazine, mesotrione and nicosulfuron and preparation method thereof | |
| CN106889106B (en) | Plant growth regulator for dry farming rice | |
| CN105028448B (en) | A kind of ternary weeding composition containing florasulam | |
| CN115777700A (en) | Suspending agent containing metribuzin and topramezone and preparation method thereof | |
| CN114467928B (en) | Suspending agent containing dimethomorph and cyazofamid and preparation method thereof | |
| CN114208833B (en) | Pesticide composition containing fluroxypyr and diclosulam as well as preparation method and application thereof | |
| CN115363040A (en) | Suspending agent containing topramezone and amicarbazone and preparation method thereof | |
| CN108432774A (en) | A kind of herbicidal composition of rice terrace | |
| CN109042689A (en) | A kind of built herbicide for rice field composition | |
| CN114223663A (en) | Suspending agent containing chlorantraniliprole and chlorfenapyr and preparation method thereof | |
| CN110973141B (en) | Weeding composition, weeding preparation and application thereof | |
| CN115251080B (en) | Weeding composition for preventing and treating wild spotted maigre and application thereof | |
| CN113331194B (en) | Weeding composition containing clethodim and halauxifen-methyl | |
| BR102022012438A2 (en) | SUSPENSION CONCENTRATE CONTAINING PYROXASULFONE AND FLUMIOXAZINE AND METHOD OF PREPARATION THEREOF | |
| CN115104622B (en) | Compound composition of glufosinate-ammonium and topramezone | |
| CN111903690B (en) | Herbicidal composition containing dithiopyr and application thereof | |
| CN111328817A (en) | Weeding composition containing metamifop and flumetsulam and application thereof | |
| CN116725019A (en) | Methanesulfonyl bacteria azole suspending agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |