CN115768416A - 图卡替尼联合曲妥珠单抗和基于奥沙利铂的化学疗法治疗her2阳性癌症的方法 - Google Patents

图卡替尼联合曲妥珠单抗和基于奥沙利铂的化学疗法治疗her2阳性癌症的方法 Download PDF

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CN115768416A
CN115768416A CN202180038814.2A CN202180038814A CN115768416A CN 115768416 A CN115768416 A CN 115768416A CN 202180038814 A CN202180038814 A CN 202180038814A CN 115768416 A CN115768416 A CN 115768416A
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cancer
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tucatinib
trastuzumab
oxaliplatin
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Chinese (zh)
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L·沃克
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Sijin Co
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Sijin Co
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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  • Medicinal Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180038814.2A 2020-05-29 2021-05-28 图卡替尼联合曲妥珠单抗和基于奥沙利铂的化学疗法治疗her2阳性癌症的方法 Pending CN115768416A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063032223P 2020-05-29 2020-05-29
US63/032,223 2020-05-29
PCT/US2021/034715 WO2021243123A1 (en) 2020-05-29 2021-05-28 Methods of treating her2 positive cancer with tucatinib in combination with trastuzumab and an oxaliplatin-based chemotherapy

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CN115768416A true CN115768416A (zh) 2023-03-07

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CN202180038814.2A Pending CN115768416A (zh) 2020-05-29 2021-05-28 图卡替尼联合曲妥珠单抗和基于奥沙利铂的化学疗法治疗her2阳性癌症的方法

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US (1) US20230173067A1 (https=)
EP (1) EP4157257A1 (https=)
JP (1) JP2023527794A (https=)
KR (1) KR20230027068A (https=)
CN (1) CN115768416A (https=)
AU (1) AU2021281336A1 (https=)
CA (1) CA3183592A1 (https=)
IL (1) IL298538A (https=)
MX (1) MX2022014886A (https=)
WO (1) WO2021243123A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025103441A1 (zh) * 2023-11-16 2025-05-22 上海复宏汉霖生物技术股份有限公司 联合抗her2抗体和化疗剂治疗胃癌的方法及用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120091828A (zh) * 2022-10-12 2025-06-03 中外制药株式会社 含有肽、表面活性剂和聚合物的组合物
WO2024130003A1 (en) * 2022-12-15 2024-06-20 Bolt Biotherapeutics, Inc. Cancer combination treatment method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU2012323890A1 (en) 2011-10-14 2014-05-29 Array Biopharma Inc. Polymorphs of arry-380, a selective ErbB2 inhibitor and pharmaceutical compositions containing them
WO2013056108A2 (en) 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
EP3344251B1 (en) * 2015-09-04 2021-04-28 Aslan Pharmaceuticals PTE Limited A combination therapy comprising varlitinib and an anticancer agent
PT3589661T (pt) * 2017-03-02 2024-01-29 Genentech Inc Tratamento com adjuvante de cancro da mama positivo para her2
BR112019022280A2 (pt) * 2017-04-28 2020-05-19 Seattle Genetics Inc tratamento de cânceres de her2 positivo
EP3727368A4 (en) * 2017-12-19 2021-10-20 Abraxis BioScience, LLC METHOD OF TREATMENT IN COLON CANCER WITH NANOPARTICLE MTOR INHIBITOR COMBINATION THERAPY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025103441A1 (zh) * 2023-11-16 2025-05-22 上海复宏汉霖生物技术股份有限公司 联合抗her2抗体和化疗剂治疗胃癌的方法及用途

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IL298538A (en) 2023-01-01
US20230173067A1 (en) 2023-06-08
AU2021281336A1 (en) 2022-12-15
KR20230027068A (ko) 2023-02-27
WO2021243123A1 (en) 2021-12-02
CA3183592A1 (en) 2021-12-02
MX2022014886A (es) 2023-01-04
EP4157257A1 (en) 2023-04-05
JP2023527794A (ja) 2023-06-30

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