CN115737892B

CN115737892B - Elastic dressing carrying repair matrix and preparation method thereof

Info

Publication number: CN115737892B
Application number: CN202211454435.4A
Authority: CN
Inventors: 陈丽; 侯新国; 吕彬; 刘福强; 段武; 王海鹏; 和法莲; 高双; 吴蓉
Original assignee: Nolai Biomedical Technology Co ltd; Qilu Hospital of Shandong University
Current assignee: Nolai Biomedical Technology Co ltd; Qilu Hospital of Shandong University
Priority date: 2022-11-21
Filing date: 2022-11-21
Publication date: 2024-06-14
Anticipated expiration: 2042-11-21
Also published as: CN115737892A

Abstract

The present disclosure describes an elastic dressing for carrying a repair matrix, comprising a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of receiving parts having receiving spaces and for receiving the repair matrix, the receiving parts being recesses from the lower surface to the upper surface, the recesses having openings located on the lower surface, the repair matrix being dry powder-like and located in the receiving spaces, the carrier layer having a natural state and a stretched state, the openings being in a collapsed state to hold the repair matrix in the receiving spaces when the carrier layer is in the natural state, and the openings being in an open state to release the repair matrix in the receiving spaces when the carrier layer is in the stretched state. According to the present disclosure, an elastic dressing that can carry a large number of repair matrices and is easy to use can be provided. In addition, the present disclosure also provides a method for preparing the above elastic dressing.

Description

Elastic dressing carrying repair matrix and preparation method thereof

Technical Field

The invention relates to the technical field of biomedical engineering, in particular to an elastic dressing carrying a repair matrix and a preparation method thereof.

Background

With the development of modern medical technology, in recent years, people gradually recognize that wound healing is related to the environment where a wound is located, and a repair matrix with proper form and proper dosage is applied to the wound, so that the wound healing is facilitated.

The wound dressing is an article used for dressing a wound, and can carry medicines through the dressing to repair the wound surface when the dressing is applied. Traditional medical dressings are usually prepared by spreading a drug on the surface of the dressing facing the wound surface, and bringing the drug into contact with the surface of the wound surface during application; or the medicine is adsorbed in the adsorption layer of the dressing, when the dressing is applied to the wound surface, the dressing can adsorb the exudates of the wound surface, and when the medicine is dissolved in the exudates, the medicine can move to the wound surface through the molecular diffusion action between the liquids; or mixing the medicine with carrier to form ointment, and applying the ointment onto gauze, cotton, bandage, etc. to make the medicine contact with the surface of wound.

However, in the scheme of spreading the medicine on the surface of the dressing facing the wound surface and bringing the medicine into contact with the surface of the wound surface during application, the medicine is difficult to uniformly spread on the surface of the dressing, and meanwhile, the operation flow is complicated because the medicine needs to be spread firstly and then applied; in the scheme that the medicine is adsorbed in the adsorption layer of the dressing, the amount of the medicine which can be carried by the adsorption structure in the adsorption layer is often less, and the repairing effect is also less ideal; in the scheme of uniformly mixing the medicine and the carrier agent to form the ointment and then arranging the ointment on the dressing, the ointment has fewer effective active factors and can influence the repairing effect of the dressing on the wound.

Disclosure of Invention

In view of the above-described conventional circumstances, an object of the present disclosure is to provide an elastic dressing which can carry a large amount of repair matrix and is easy to use, and a method for producing the same.

To this end, a first aspect of the present disclosure provides an elastic dressing for carrying a repair matrix, comprising a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of accommodating parts having accommodating spaces for accommodating the repair matrix, the accommodating parts being grooves recessed from the lower surface toward the upper surface, the grooves having openings in the lower surface, the repair matrix being in a dry powder form and being located in the accommodating spaces, the carrier layer having a natural state and a stretched state, the openings being in a collapsed state to hold the repair matrix in the accommodating spaces when the carrier layer is in the natural state, and the openings being in an open state to release the repair matrix in the accommodating spaces when the carrier layer is in the stretched state.

In a first aspect of the present disclosure, an elastic dressing includes a carrier layer having elasticity, the carrier layer having a plurality of receiving parts having receiving spaces for receiving a repair matrix, the receiving parts having the receiving spaces therein can be made elastic by providing the carrier layer to have elasticity, thereby facilitating the receiving parts to receive a predetermined range of amounts of repair matrix; by providing the accommodating portion in a recessed groove form recessed from the lower surface toward the upper surface, filling of the repairing matrix into the accommodating portion can be facilitated, and the accommodating portion can be made to better accommodate the repairing matrix; the unit volume of the dry powder type repair matrix can store more effective active factors than the unit volume of the liquid type repair matrix, in this case, the accommodating part can accommodate the repair matrix with more effective active factors by setting the repair matrix into the dry powder type, thereby being beneficial to the healing of wound surfaces, and meanwhile, the effective active factors can have longer retention period in the dry powder type repair matrix; the groove is provided with an opening positioned on the lower surface, the elastic dressing is in a natural state and a stretching state, when the elastic dressing is in the natural state, the opening is in a furled state, the repair matrix can be kept in the accommodating space through the furled opening, and meanwhile, the repair matrix can be effectively separated from the external environment, so that the storage period of the repair matrix is prolonged; when the elastic dressing is in a stretched state, the opening is in an open state, and the repair matrix in the accommodating space can be released to the outside through the open opening; when the target surface is a wound surface, applying the elastic dressing of the present disclosure to the wound surface can bring the repair matrix into contact with the wound, thereby being capable of promoting wound healing. Thus, with the elastic dressing of the present disclosure, a large amount of repair matrix can be carried and convenient to use.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, when the carrier layer is in the natural state, a natural widest inner diameter of the accommodating portion is 0.5mm to 0.8mm, and when the carrier layer is in the stretched state, a stretched widest inner diameter of the accommodating portion is 150% to 300% of the natural widest inner diameter. In this case, when the shape of the receiving portion is determined, it is possible to facilitate filling the receiving portion with a desired amount of the repair matrix by adjusting the natural widest inner diameter of the receiving portion, to make the stretched widest inner diameter of the receiving portion 150% to 300% of the natural widest inner diameter by stretching, to facilitate releasing the repair matrix in the receiving space, and to effectively reduce the possibility of undesired deformation of the structure of the receiving portion and/or the receiving portion due to the elastic deformation of the receiving layer exceeding the elastic limit.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the plurality of accommodating portions are arranged in an array, and when the carrier layer is in the natural state, a pitch of two adjacent openings among the plurality of accommodating portions is 3mm to 5mm. Under this circumstance, through arranging the accommodation portion in an array, the repair matrix can be favorably released to the wound surface uniformly, and through adjusting the interval between two adjacent openings in the openings of the plurality of accommodation portions, the density of the accommodation portions in the bearing layer can be conveniently controlled, thereby the amount of the repair matrix released to the wound surface of unit area can be conveniently controlled, and the healing of the wound is favorably realized.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the carrier layer has super hydrophilicity. In this case, when the elastic dressing is stretched and applied to the target surface having the liquid layer, part of the liquid on the region of the target surface corresponding to the opening enters the accommodating portion via the opening to be absorbed by the carrier layer, whereby the possibility of occurrence of wound dead space (i.e., a cavity mainly composed of necrotic tissue) and/or wound infection due to accumulation of excessive exudates on the wound surface for a long period of time can be effectively reduced, thereby facilitating wound healing.

In addition, in the elastic dressing according to the first aspect of the present disclosure, an area of the lower surface other than the opening may be referred to as a first area, and the elastic dressing may further include a superhydrophobic structure disposed in the first area. In this case, when the elastic dressing is stretched and applied to the target surface having the liquid layer, the liquid on the region of the target surface corresponding to the first region can be at least partially held by the superhydrophobic structure provided on the first region, thereby leaving the region of the target surface corresponding to the first region in a moist environment, thereby providing a good healing environment for the wound surface, and in addition, when the elastic dressing needs to be peeled from the wound surface, since the region of the target surface corresponding to the first region is in a moist environment, the superhydrophobic property on the surface of the superhydrophobic structure in contact with the wound can cause it to exhibit anti-blocking properties against wound secretions, granulation tissue on the wound surface, and the like, thereby enabling the adhesion of the elastic dressing to the granulation tissue newly generated by the wound to be reduced, enabling it to be easily peeled from the wound surface, thereby enabling the possibility of secondary damage to the wound caused by peeling of the elastic dressing from the wound surface to be reduced.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the superhydrophobic structure includes a plurality of micrometer-scale protrusions arranged at intervals on the first region, and nanoparticles disposed on surfaces of the micrometer-scale protrusions. Thus, the hydrophobic performance of the superhydrophobic structure can be enhanced.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the elastic dressing further includes an insulating layer having hydrophobicity, and the insulating layer is provided on the upper surface. Under the condition, the hydrophobic isolation layer is arranged on the upper surface of the bearing layer, so that pollutants in the external environment can be effectively resisted from entering the dressing, a barrier effect is achieved, and the infection risk of a wound surface can be effectively reduced.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the elastic moduli of the isolation layer, the carrier layer, and the superhydrophobic structure are the same or similar. Under the condition, when the elastic dressing is stretched or the elastic dressing is stopped from being stretched and the elastic dressing is retracted to a natural state, the isolation layer, the bearing layer and the super-hydrophobic structure can be synchronously deformed, so that the phenomenon that the elastic dressing is undesirably deformed during stretching and/or retraction due to the fact that the elastic modulus difference exists in the inner structure of the elastic dressing can be effectively avoided.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the elastic dressing further includes a sealing film provided on the lower surface, the sealing film completely covering the plurality of openings when the carrier layer is in the natural state. In this case, the storage stability of the repair matrix in the accommodating portion can be improved by the covering effect of the sealing film on the opening, and the repair matrix can be effectively prevented from being scattered to the outside through the opening when the carrying layer is in a natural state.

A second aspect of the present disclosure provides a method for preparing an elastic dressing carrying a repair matrix, characterized in that the method comprises: preparing a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface; transversely stretching the bearing layer to enable the bearing layer to be in a stretched state; machining the lower surface of the bearing layer in the stretched state to form a plurality of accommodating parts with accommodating spaces, wherein the accommodating parts are grooves which are concave from the lower surface to the upper surface, and the grooves are provided with openings positioned on the lower surface; filling the repair matrix into the accommodating space through the opening, wherein the repair matrix is in a dry powder form; stopping stretching the bearing layer, retracting the bearing layer to a natural state, and gathering the opening to keep the repair matrix in the accommodating space, so as to obtain the elastic dressing. In the second aspect of the present disclosure, by using the manufacturing method to manufacture an elastic dressing, an elastic dressing that can carry a large amount of repair matrix and is easy to use can be obtained.

According to the present disclosure, an elastic dressing that can carry a large amount of repair matrix and is easy to use and a method for producing the same can be provided.

Drawings

Fig. 1 is a schematic diagram illustrating a first embodiment of an elastic dressing to which examples of the present disclosure relate.

Fig. 2 is a schematic cross-sectional view showing an elastic dressing according to an example of the present disclosure in a natural state.

Fig. 3 is a schematic cross-sectional view showing an elastic dressing according to an example of the present disclosure in a stretched state.

Fig. 4 is a schematic structural view showing a housing portion according to an example of the present disclosure.

Fig. 5 is a schematic structural view showing another embodiment of the housing part according to the example of the present disclosure.

Fig. 6 is a schematic diagram showing a housing-mounted repair matrix according to an example of the present disclosure.

Fig. 7 is a schematic diagram illustrating the release of a repair matrix by a receptacle according to an example of the present disclosure.

Fig. 8 is a schematic diagram illustrating a receptacle according to an example of the present disclosure releasing a repair matrix to a target surface.

Fig. 9 is a schematic diagram illustrating a superhydrophobic structure to which examples of the present disclosure relate.

Fig. 10 is a schematic diagram illustrating another embodiment of an elastic dressing to which examples of the present disclosure relate.

Fig. 11 is a flowchart illustrating a method of preparing an elastic dressing according to an example of the present disclosure.

Reference numerals illustrate:

1 … elastic dressing, 10 … super-hydrophobic structure, 11 … micron-sized bulges, 12 … nano particles, 20 … bearing layer, 21 … upper surface, 22 … lower surface, 23 … containing part, 231 … lower half, 232 … upper half, 24 … opening, 25 … sealing film, 30 … isolation layer, 40 … first protective film, 50 … second protective film, 9 … wound surface, 90 … liquid layer and S … first region.

Detailed Description

All references cited in this disclosure are incorporated by reference in their entirety as if fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same members are denoted by the same reference numerals, and overlapping description thereof is omitted. In addition, the drawings are schematic, and the ratio of the sizes of the components to each other, the shapes of the components, and the like may be different from actual ones.

A first aspect of the present disclosure relates to an elastic dressing carrying a repair matrix, which is a dressing that can be used to protect and repair a target surface. The elastic dressing carrying the repair matrix according to the first aspect of the present disclosure may be simply referred to as an "elastic dressing" or "dressing", and may also be referred to as a dressing carrying the repair matrix, an administration dressing, a repair dressing, a wound dressing, or the like. According to the elastic dressing, a proper amount of repair matrix can be uniformly provided for a wound surface.

In the present disclosure, the target surface may be a wound surface. The wound surface is a damage caused by injury of normal skin (tissue), and can be a wound caused by scald, abrasion, cutting injury, sprain, ulcer, frostbite and the like. That is, a wound surface may refer to the surface of a wound. In other examples, the target surface may also be other surfaces, such as a skin surface. It is noted that the elastic dressing according to the present disclosure may also be applied as a protective layer to e.g. a scabbed dried semi-healing wound.

The elastic dressing according to the present disclosure will be described below with reference to the accompanying drawings, taking the target surface as a wound surface as an example.

Fig. 1 is a schematic diagram showing a first embodiment of an elastic dressing 1 to which examples of the present disclosure relate. Fig. 2 is a schematic cross-sectional view showing the elastic dressing 1 according to the example of the present disclosure in a natural state. Fig. 3 is a schematic cross-sectional view showing the elastic dressing 1 according to the example of the present disclosure in a stretched state.

In some examples, the elastic dressing 1 may include a carrier layer 20 (see fig. 1). In some examples, the carrier layer 20 may have a plurality of receiving portions 23 (see fig. 2) having receiving spaces for receiving the repair matrix. In this case, the plurality of receiving portions 23 provided on the support layer 20 can allow the support layer 20 to receive a large amount of repair matrix, thereby facilitating recovery of the wound surface 9 when in use.

In some examples, the carrier layer 20 may have a lower surface 22 that faces the target surface when applied, and an upper surface 21 opposite the lower surface 22 (see fig. 2). In some examples, the receptacle 23 may be a recess recessed from the lower surface 22 toward the upper surface 21 (see fig. 2). In this case, by providing the accommodating portion 23 in the form of a groove recessed from the lower surface 22 toward the upper surface 21, filling of the accommodating portion 23 with the repair matrix can be facilitated, while enabling the accommodating portion 23 to better accommodate the repair matrix. In some examples, the recess may have an opening 24 located at the lower surface 22. In this case, the repair matrix can be transferred to and from the housing portion 23 through the opening 24.

In some examples, the repair matrix may be located within the containment space. This can facilitate the elastic dressing 1 to carry the repair matrix. In some examples, the repair matrix may be in the form of a dry powder. The dry powdered healing matrix can contain a higher concentration of the active factor than the liquid/gel-state healing matrix, in other words, the dry powdered healing matrix can store a larger amount of the active factor per unit volume than the liquid-state healing matrix, in which case, by setting the healing matrix to the dry powder, the accommodating portion 23 can accommodate the healing matrix with a larger amount of the active factor, thereby facilitating the healing of the wound surface 9, and at the same time, the active factor can have a longer shelf life in the dry powdered healing matrix.

In some examples, the carrier layer 20 may have elasticity. In some examples, the carrier layer 20 may have a natural state and a stretched state (see fig. 2, 3). When the carrier layer 20 is in a natural state, the opening 24 may be in a folded state (see fig. 2). The opening 24 may be in an open state when the carrier layer 20 is in a stretched state (see fig. 3). In this case, the restoration matrix can be held in the accommodation space by the folded opening 24 while being effectively separated from the external environment, thereby contributing to the prolongation of the storage life of the restoration matrix; the healing matrix located in the receiving space can be released to the outside through the open opening 24 by stretching the carrier layer 20, and when the target surface is the wound surface 9, the healing matrix can be released to the wound surface 9, so that the healing matrix is brought into contact with the wound, whereby the wound healing can be promoted.

It should be noted that, in the present disclosure, the natural state of the carrier layer 20 may refer to a state that the carrier layer 20 is not affected by an external force. The stretched state of the carrier layer 20 may refer to a state in which the carrier layer 20 is deformed by an external tensile force. For example, the carrier layer 20 may be laterally stretched to open the openings 24. In the example shown in fig. 3, the left and right ends of the carrier layer 20 are respectively subjected to external pulling forces in the left and right directions (directions D1 and D2 shown in fig. 3), and the folded state of the opening 24 shown in fig. 2 is changed to the open state shown in fig. 3. In some examples, a plurality of external pulling forces may also be applied to the carrier layer 20 along a direction parallel to the upper surface 21 or the lower surface 22 of the carrier layer 20 and toward the outside of the carrier layer 20 to stretch it to a predetermined configuration. In some examples, the plurality of external pulling forces may be oppositely disposed. For example, when the amount of external pulling force is 2, the directions of the 2 external pulling forces may be set to be directed from the center of the carrier layer 20 to the outside of the carrier layer 20 and the directions of the 2 external pulling forces are opposite. This can facilitate uniform stretching of the support layer 20.

In some examples, the natural widest inner diameter of the receiving portion 23 may be 0.5mm to 0.8mm when the bearing layer 20 is in a natural state. In this case, when the shape of the accommodating portion 23 is determined, the volume of the accommodating space can be adjusted by adjusting the natural widest inner diameter of the accommodating portion 23, whereby filling a desired amount of repair matrix into the accommodating portion 23 can be facilitated.

In some examples, the stretched widest inner diameter of the receptacle 23 may be 150% to 300% of the natural widest inner diameter when the carrier layer 20 is in a stretched state. In this case, by stretching the support layer 20, it is possible to facilitate release of the repair matrix in the accommodating space, while at the same time it is possible to effectively reduce the possibility of undesired deformation of the structure of the support layer 20 and/or the accommodating portion 23 due to the elastic deformation of the support layer 20 exceeding the superelastic limit.

In some examples, the plurality of receptacles 23 may be arranged in an array. Thereby, it is possible to facilitate the repair matrix in the accommodation portion 23 to be uniformly released to the wound surface 9. In some examples, when the carrier layer 20 is in a natural state, a pitch of adjacent two openings 24 among the openings 24 of the plurality of receiving portions 23 may be 3mm to 5mm. In this case, by adjusting the interval between adjacent two openings 24 among the openings 24 of the plurality of receiving portions 23, it is possible to facilitate control of the density of the receiving portions 23 in the carrier layer 20, whereby it is possible to facilitate control of the amount of the repair matrix released to the wound surface 9 per unit area, thereby facilitating the healing of the wound.

Fig. 4 is a schematic diagram showing the structure of the accommodation portion 23 according to an example of the present disclosure.

In some examples, the receptacle 23 may be generally ellipsoidal (see fig. 4). In this case, by providing the accommodating portion 23 in a relatively regular shape, it is possible to facilitate processing of the carrier layer 20 to form the accommodating portion 23; meanwhile, when the elastic dressing 1 is in a natural state, the inner wall of the ellipsoidal accommodating part 23 can generate pressure towards the inside of the accommodating space to the repairing matrix in the accommodating space more uniformly, so that the repairing matrix can be maintained in the accommodating space more stably.

In some examples, the receiving portion 23 may have an ellipsoidal shape with an opening 24 at the bottom (see fig. 4). In this case, by disposing the opening 24 at the bottom of the accommodating portion 23, when the carrier layer 20 is in a natural state, the bottom of the accommodating portion 23 can be made to assume a form of being folded from the periphery toward the center, and the repair matrix can be further firmly held; since the inner wall of the accommodating portion 23 has a smoothly curved shape, it is possible to facilitate guiding the transfer of the repair matrix from the opening 24 to the outside when the support layer 20 is in a stretched state to release the repair matrix.

Fig. 5 is a schematic structural view showing another embodiment of the accommodating portion 23.

In some examples, the lower half 231 of the receiving portion 23 may have a semi-elliptical shape having the opening 24, and the upper half 232 of the receiving portion 23 may have a cylindrical shape (see fig. 5) that matches the lower half 231. In some examples, the mating of the upper half 232 of the receptacle 23 with the lower half 231 means that the upper half 232 of the receptacle 23 engages with the lower half 231. In this case, the bottom of the accommodating portion 23 is in a form of being folded from the periphery to the center, and the cylindrical upper half 232 has a larger accommodating space than the hemispherical upper half 232, so that the cylindrical upper half 232 can accommodate more repair matrix, and the elastic dressing 1 can be provided with more repair matrix by matching the upper half 232 with the lower half 231 of the accommodating portion 23 and smoothly release the repair matrix in a stretched state, thereby being better adapted to the needs in different scenes. The present disclosure is not limited thereto, and the shape of the accommodating portion 23 may be adjusted according to actual needs, for example, the accommodating portion 23 may have a rounded cone shape with an opening 24 at the bottom. In some examples, the receptacle 23 may be any regular or irregular shape with a bottom having an opening 24 in a collapsed configuration.

Fig. 6 is a schematic diagram showing mounting of the repair matrix in the housing portion 23 according to an example of the present disclosure. Fig. 7 is a schematic view showing that the accommodating portion 23 according to the example of the present disclosure releases the repair matrix. In fig. 7, arrows schematically represent the moving direction of the repair matrix.

In some examples, the elastic dressing 1 may further include a sealing film 25 (see fig. 6) provided to the lower surface 22. When the carrier layer 20 is in a natural state, the sealing film 25 may completely cover the plurality of openings 24. In this case, the covering effect of the sealing film 25 on the opening 24 can improve the storage stability of the repair matrix in the accommodating portion 23, effectively prevent the repair matrix from being spilled to the outside through the opening 24 when the carrier layer 20 is in a natural state, and can reduce the contact between the repair matrix in the accommodating portion 23 and the external environment, thereby prolonging the shelf life.

In some examples, the number of sealing films 25 may be plural, and each sealing film 25 may cover each opening 24, respectively. When the support layer 20 is in a stretched state, the inner diameter of the opening 24 becomes wider, and the sealing film 25 does not completely cover at least the opening 24, and at this time, the inner space of the accommodating portion 23 can communicate with the outside through the opening 24. Thereby, the repair matrix in the accommodation portion 23 can be released in a stretched state via the opening 24.

In some examples, sealing film 25 may be separated from opening 24 when carrier layer 20 is in a stretched state. In other words, the sealing film 25 may be completely separated from the opening 24. In this case, the repair matrix can be facilitated to be transferred to the outside through the opening 24.

Referring to fig. 6 and 7, when the carrier layer 20 is in a natural state, the sealing film 25 may entirely cover the opening 24; when the support layer 20 is in a stretched state, the inner diameter of the opening 24 becomes wider, the sealing film 25 can be separated from the opening 24, and the repair matrix in the receiving part 23 can be transferred to the outside through the opening 24.

In some examples, the sealing film 25 may also be in a whole sheet shape and completely cover the lower surface 22 of the carrier layer 20. In this case, the sheet-like sealing film 25 covering the lower surface 22 can completely cover the respective openings 24, improving the preservation stability of the repair matrix in the accommodating portion 23; further, the application of the sealing film 25 to the covering of the respective openings 24 can be simplified with respect to the case where a plurality of sealing films 25 are provided.

In some examples, the entire sheet of sealing film 25 may not completely cover all of the openings 24 when the carrier layer 20 is in a stretched state. In this case, the carrier layer 20 is stretched, that is to say the elastic dressing 1 is also stretched, and the whole sheet-shaped sealing film 25 breaks under the stretching, since the sealing film 25 no longer covers the opening 24, and at the same time the inner diameter of the opening 24 widens under the stretching, the healing matrix in the receiving portion 23 can be released via the opening 24.

In some examples, a unitary sheet of sealing film 25 may be detachably disposed to the lower surface 22 of the carrier layer 20. Before use, the sealing film 25 may be peeled off the lower surface 22, and then the carrier layer 20 may be stretched to release the repair matrix.

In some examples, the sealing film 25 may have water solubility. In this case, when the sealing film 25 is in contact with exudates on the wound surface 9, it can be dissolved in the exudates, thereby facilitating the release of the healing matrix located in the receiving space.

In some examples, sealing film 25 may include a substance that facilitates wound healing. For example, the composition of the sealing film 25 may be similar or identical to the composition of the repair matrix. In this case, it can be advantageous to promote healing of the wound surface 9.

In some examples, the carrier layer 20 may have super-hydrophilicity. In this case, when the elastic dressing 1 is stretched and the elastic dressing 1 is applied to the target surface having the liquid layer 90, a part of exudates on the region of the target surface corresponding to the opening 24 enters the containing portion 23 via the opening 24 and is absorbed by the carrier layer 20, whereby the possibility of occurrence of dead wound cavities (i.e., cavities mainly of necrotic tissue) and/or wound infections due to accumulation of excessive exudates on the wound bed 9 for a long period of time can be effectively reduced, thereby facilitating wound healing.

In some examples, the area of the lower surface 22 other than the opening 24 may be referred to as a first area S (see fig. 2). In some examples, the elastic dressing 1 may further comprise a superhydrophobic structure 10 (see fig. 2) disposed at the first region S. In this case, when the elastic dressing 1 is stretched and the elastic dressing 1 is applied to the target surface having the liquid layer 90, the liquid on the region of the target surface corresponding to the first region S can be at least partially held by the superhydrophobic structure 10 provided on the first region S, so that the region of the target surface corresponding to the first region S is in a moist environment, thereby enabling to provide a suitable healing environment for the wound surface 9. In addition, when the elastic dressing 1 needs to be peeled off from the wound surface 9, since the region of the target surface corresponding to the first region S is in a suitable moist environment, the superhydrophobic property on the surface of the superhydrophobic structure 10 in contact with the wound can make it play an anti-adhesion role on wound secretions, granulation tissues on the surface of the wound and the like, so that adhesion of the elastic dressing 1 to the granulation tissues newly generated by the wound can be reduced, the elastic dressing 1 is easy to peel off from the wound surface 9, and the possibility of secondary injury to the wound caused by peeling off the elastic dressing 1 from the wound surface 9 can be reduced.

It should be noted that in the present disclosure, providing a suitable moist/healing environment for the wound surface 9 means that the wound surface 9 can be moist but not soaked in liquid by the elastic dressing 1 of the present disclosure.

In some examples, the sealing film 25 may be disposed on a surface of the superhydrophobic structure 10 that is relatively far from the carrier layer 20. In some examples, the area of the sealing film 25 may be not less than the area of the surface of the superhydrophobic structure 10 and the sealing film 25 can completely cover the surface of the superhydrophobic structure 10. This can further improve the stability of holding the repair matrix in the accommodating portion 23.

In some examples, when it is desired to apply the elastic dressing 1 to the wound surface 9, the elastic dressing 1 may be stretched first, and then the elastic dressing 1 in the stretched state may be applied to the wound surface 9. In this case, the repair matrix in the receiving space can be released continuously to the wound bed 9 through the open opening 24, promoting wound healing. In some examples, during stretching of the elastic dressing 1 and application of the elastic dressing 1 in a stretched state to the wound surface 9, the opening 24 of the accommodating portion 23 may be applied to the wound surface 9 in a state of being kept facing upward. In this case, by making the opening 24 of the accommodating portion 23 face upward, the repair matrix can be effectively prevented from being scattered from the accommodating space to the outside during the stretching of the elastic dressing 1.

In some examples, when it is desired to apply the elastic dressing 1 to the wound surface 9, the opening 24 of the receiving portion 23 may be first stretched toward the wound surface 9 to release the repair matrix portion to the wound surface 9, then the stretching of the elastic dressing 1 is stopped, the elastic dressing 1 is retracted to a natural state, and then the elastic dressing 1 is applied to the wound surface 9. In this case, after the repair matrix is partially released to the wound surface 9, the amount of the remaining repair matrix in the accommodating portion 23 is reduced, and the overall density is lowered, at which time even if the elastic dressing 1 is rebounded to the natural state, the inner wall of the accommodating portion 23 no longer generates a pressure sufficient to hold the remaining repair matrix in the accommodating space, and when the elastic dressing 1 in the natural state is applied to the wound surface 9, the repair matrix in the accommodating portion 23 can be gradually transferred to the wound surface 9 through the opening 24; meanwhile, the situation that the wound surface 9 to which the dressing is applied is shrunk and the skin except the wound surface 9 to which the dressing is applied is tensed due to the rebound effect of the elastic dressing 1 after the elastic dressing is applied to the wound surface 9 can be effectively reduced, and therefore the use comfort of the elastic dressing 1 is improved.

Fig. 8 is a schematic view showing that the accommodating portion 23 according to the example of the present disclosure releases the repair matrix to the target surface. In fig. 8, arrows schematically indicate the moving direction of the repair substrate.

In some examples, the superhydrophobic structure 10 may be in contact with the wound surface 9 when the elastic dressing 1 is applied to the wound surface 9 (see fig. 8). In some examples, there may be a liquid layer 90 between the wound surface 9 and the first region S of the superhydrophobic structure 10, which is constituted by exudates secreted by the wound surface 9 (see fig. 8). In this case, wound healing can be facilitated by providing the wound bed 9 with a suitably moist environment.

In some examples, the repair matrix may have water solubility. In this case, when the elastic dressing 1 in a stretched state is applied to the wound surface 9, the repair matrix can be released to the wound surface 9, and the repair matrix can repair the wound surface 9 by contacting the wound surface 9, being dissolved in exudates on the wound surface 9. In some examples, the repair matrix may diffuse through the liquid layer 90 to the area of the wound 9 corresponding to the first region S. Thereby, the healing of the wound surface 9 can be facilitated. In some examples, sealing film 25 may also have water solubility.

In some examples, the repair matrix may move downward by osmosis after diffusing into the area of the wound 9. It will be appreciated that migration of the repair matrix downwards by osmosis means that the repair matrix may migrate from the wound 9 deep into the skin by osmosis. Thereby, the healing of the wound can be further promoted.

In some examples, when the healing matrix dissolves in the exudates, the excess exudates on the area of the wound surface 9 corresponding to the opening 24 may also migrate into the receptacle 23 by osmosis in the healing matrix. The carrier layer 20 has super-hydrophilicity, that is, the inner wall of the accommodating portion 23 also has super-hydrophilicity, and excessive exudates can be absorbed by the carrier layer 20 by moving toward the accommodating portion 23 and contacting the inner wall of the accommodating portion 23, thereby effectively reducing the possibility of occurrence of dead wound cavities (i.e., cavities mainly composed of necrotic tissue) and/or wound infection due to accumulation of excessive exudates on the wound surface 9 for a long time, and facilitating wound healing.

In some examples, the repair matrix may include mesenchymal stem cells and/or derivatives of mesenchymal stem cells. For example, in some examples, the repair matrix may include a supernatant of mesenchymal stem cells. The supernatant of the mesenchymal stem cells contains a substance capable of promoting wound healing, in which case healing of the wound can be facilitated when the repair matrix is in contact with the wound surface 9.

In some examples, the repair matrix may be in a lyophilized powder form. In this case, the concentration of the effective active cytokine per unit volume of the stem cell supernatant in the form of a lyophilized powder is higher and the shelf life of the bioactive substance is longer than that of the stem cell supernatant in the form of a liquid, and when the mesenchymal stem cell supernatant in the form of a lyophilized powder is mounted on the carrier layer 20, the elastic dressing 1 of the present disclosure can be made convenient for storage and clinical application.

In some examples, mesenchymal stem cell-derived exosomes may be included in the supernatant of mesenchymal stem cells. Wherein the exosomes are extracellular vesicles secreted by the cells comprising complex RNAs and proteins. In this case, the exosomes derived from the mesenchymal stem cells can promote the healing of the wound surface 9 by paracrine action, inhibit inflammatory reaction of the wound surface 9, promote angiogenesis, improve extracellular matrix environment, and mobilize cells of the body to migrate to the damaged part, thereby repairing the wound surface 9.

In some examples, the supernatant of the mesenchymal stem cells may further include one or more of vascular endothelial growth factor, epidermal growth factor, transforming growth factor-beta, liver growth factor, superoxide dismutase, interleukin-6, collagen, fibronectin, and platelet derived factor. In this case, the healing of the wound can be facilitated by the repair matrix.

In some examples, the supernatant of the mesenchymal stem cells may include one or more of exosomes of the mesenchymal stem cells, vascular endothelial growth factor, epidermal growth factor, transforming growth factor- β, liver growth factor, superoxide dismutase, interleukin-6, collagen, fibronectin, and platelet derived factor. In this case, the repair ability of the repair matrix can be further improved, thereby promoting wound healing.

The present disclosure is not limited thereto, and a corresponding repair matrix may be selected according to the actual condition of the wound 9. For example, in some examples, the repair matrix may also include other components that aid in wound healing. For example, the repair matrix may also include hemostatic powders and the like.

In some examples, the mesenchymal stem cells may be umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, or adipose mesenchymal stem cells. The repair matrix may include a variety of mesenchymal stem cells and/or derivatives of mesenchymal stem cells. That is, in some examples, the repair matrix may include derivatives of one or more of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, and adipose mesenchymal stem cells. Under the condition, various mesenchymal stem cells and derivatives thereof can be beneficial to wound healing, are rich in source, and can conveniently adjust the components of the repair matrix according to actual needs.

In some examples, the medicament may be applied to the wound surface 9 prior to applying the elastic dressing 1 to the wound surface 9, and then the elastic dressing 1 is applied to the wound surface 9. Wherein, the components of the medicine can be consistent with the components of the repair matrix, and can also be other components capable of promoting wound healing. In this case, the repair matrix in combination with the drug can further enhance the repair ability to the wound, thereby promoting wound healing.

For example, in some examples, the composition of the drug may also include exosomes of umbilical mesenchymal stem cells, and the drug may also be present in the form of a lyophilized powder, at which time the drug may be uniformly sprayed onto the wound surface 9 before the elastic dressing 1 is applied to the wound surface 9. In this case, the exosomes of the umbilical cord mesenchymal stem cells can exert their biological effects, promoting the healing of the wound surface 9.

Fig. 9 is a schematic diagram illustrating a superhydrophobic structure 10 related to an example of the present disclosure. Fig. 9 is an enlarged view of a region a in fig. 6.

In some examples, the superhydrophobic structure 10 may include a plurality of micrometer-scale protrusions 11 arranged at intervals on the first region S, and nanoparticles 12 disposed on surfaces of the micrometer-scale protrusions 11 (see fig. 9). In this case, when the droplet is in contact with the surface of the superhydrophobic structure 10, a layer of air film is formed between the droplet and the surface of the superhydrophobic structure 10 due to the presence of the micro-scale protrusions 11 and the nano-particles 12, which hinders wetting of the surface of the superhydrophobic structure 10 by the liquid, thereby forming a superhydrophobic state and rendering the surface of the superhydrophobic structure 10 superhydrophobic. In the present disclosure, the superhydrophobic structure 10 including the micro-scale protrusions 11 and the nanoparticles 12 may also be referred to as a micro-nano structure.

In some examples, the micrometer-scale protrusions 11 may be mastoid, cone-shaped, or columnar. In some examples, the height of the micrometer-scale protrusions 11 is 20 μm to 150 μm. In this case, it is possible to advantageously improve the hydrophobic performance of the superhydrophobic structure 10, thereby facilitating maintenance of a wet environment, and easy peeling.

In some examples, the micrometer-scale protrusions 11 may be arranged in an array. In some examples, the pitch of two adjacent micrometer-scale protrusions 11 may be 20 μm to 200 μm. In this case, the hydrophobic performance of the superhydrophobic structure 10 is relatively uniform, so that the thickness of the liquid layer 90 formed by the liquid held between the superhydrophobic structure 10 and the wound surface 9 is substantially uniform, and the healing speed of the wound surface 9 corresponding to the superhydrophobic structure 10 tends to be uniform, which is beneficial to the healing of the wound surface 9.

In some examples, the nanoparticle 12 may have a particle size in the range of 50nm to 1000nm. The particle diameter range refers to the diameter of the nanoparticle 12 when it is spherical, and refers to the equivalent diameter of the three-dimensional structure when it is not spherical. In some examples, the number of nanoparticles 12 may be multiple, and the particle sizes and shapes of the multiple nanoparticles 12 may be the same or different (see fig. 9).

In some examples, the micro-drop contact angle of the surface of the superhydrophobic structure 10 can be greater than 150 ° and the roll angle is less than 10 °. In this case, the superhydrophobic structure 10 has superhydrophobic performance, and by providing the superhydrophobic structure 10 in the first region S, it is possible to facilitate maintenance of a moist environment between the first region S and the wound surface 9, and to easily peel the elastic dressing 1 from the wound surface 9.

In some examples, the thickness of the superhydrophobic structure 10 can be 0.1mm to 2mm. It should be noted that, in the present disclosure, the thickness of the superhydrophobic structure 10 is the thickness including the micrometer-scale protrusions 11 and the nanoparticles 12 as a whole. In this case, the superhydrophobic structure 10 is moderately thin and thick, can maintain good air permeability, and can also facilitate movement of exudates into the accommodating portion 23 by permeation in the healing matrix to be absorbed by the carrier layer 20 having superhydrophilicity. In some examples, the thickness of the superhydrophobic structure 10 may preferably be 0.1mm to 1mm.

In some examples, the superhydrophobic structure 10 can be composed of a hydrophobic material. In some examples, the material of the superhydrophobic structure 10 can be silica gel. In some examples, the superhydrophobic structure 10 can be a silicone rubber film, which can also be referred to as a PDMS (polydimethylsiloxane) film. In this case, the superhydrophobic structure 10 is soft in texture and has good biocompatibility and air permeability, has no irritation to human tissues, and can be beneficial to healing of the wound surface 9.

In some examples, the elastic dressing 1 may further comprise an isolating layer 30 having hydrophobicity. In some examples, the release layer 30 may be disposed on the upper surface 21 of the carrier layer 20 (see fig. 1). In this case, by providing the hydrophobic isolation layer 30 on the upper surface 21 of the carrier layer 20, contaminants in the external environment can be effectively resisted from entering the dressing, and a barrier effect is achieved, so that the infection risk of the wound surface 9 can be effectively reduced.

In some examples, the modulus of elasticity of the barrier layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be the same or similar. In some examples, the elastic moduli of the separation layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be similar, meaning that the elastic moduli of any two of the separation layer 30, the carrier layer 20, and the superhydrophobic structure 10 differ by no more than 10%. For example, the elastic moduli of any two of the barrier layer 30, the support layer 20, and the superhydrophobic structure 10 may differ by 1%, 2%, 5%, 8%, or 10%. In this case, when the elastic dressing 1 is stretched, or the elastic dressing 1 is stopped from being stretched to retract the elastic dressing 1 to a natural state, the separation layer 30, the carrier layer 20, and the superhydrophobic structure 10 can be simultaneously deformed, so that undesired deformation of the elastic dressing 1 at the time of stretching and/or retracting due to the difference in elastic modulus of the internal structure of the elastic dressing 1 can be effectively avoided.

In some examples, the separator layer 30, the carrier layer 20, and two adjacent layers in the superhydrophobic structure 10 may be joined to one another by an adhesive, and no adhesive is disposed in the region of the carrier layer 20 corresponding to the opening 24. In this case, a tight bond between the layers is possible and the elastic dressing 1 is facilitated to release the repair matrix via the opening 24.

Fig. 10 is a schematic diagram showing another embodiment of an elastic dressing 1 to which examples of the present disclosure relate.

In some examples, the elastic dressing 1 may further include a first protective film 40 (see fig. 10) that peelably covers the surface of the superhydrophobic structure 10. In this case, by providing the first protective film 40, the surface of the superhydrophobic structure 10 can be maintained in a clean state before use, and when the elastic dressing 1 needs to be attached to the wound surface 9, the first protective film 40 may be peeled off from the surface of the superhydrophobic structure 10.

In some examples, the shape of the first protective film 40 may match the shape of the surface of the superhydrophobic structure 10. In some examples, the shape of the first protective film 40 may match the shape of the surface of the superhydrophobic structure 10, meaning that the area of the first protective film 40 is not less than the area of the surface of the superhydrophobic structure 10 and the first protective film 40 can completely cover the surface of the superhydrophobic structure 10. Thereby, the first protective film 40 can be made to better protect the superhydrophobic structure 10.

In some examples, the elastic dressing 1 may further include a second protective film 50 (see fig. 10) that peelably covers a surface of the release layer 30 that is relatively far from the carrier layer 20. In this case, by providing the second protective film 50, the surface of the separator 30 relatively far from the carrier layer 20 can be maintained in a clean state before use, and when the elastic dressing 1 needs to be attached to the wound surface 9, the second protective film 50 is peeled off from the surface without affecting the air permeability of the separator 30.

In some examples, the first protective film 40 and/or the second protective film 50 may be release paper. This enables effective protection.

In some examples, the barrier layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be sheet-like. In this case, the elastic dressing 1 can be facilitated to cover the target surface.

In some examples, the elastic dressing 1 may be in the form of a long roll. The elastic dressing 1 can be cut to a desired size (e.g., a shape that can cover the wound surface 9) for use and then reused.

In some examples, the elastic dressing 1 may be attached to the wound 9 by medical tape. The two ends of the isolation layer 30 can be directly extended outwards, and the inner walls of the two ends of the isolation layer 30 extended outwards are provided with adhesives, namely, the adhesive bandage is formed, so that the elastic dressing 1 can be attached to the wound surface 9.

In summary, in the first aspect of the present disclosure, an elastic dressing 1 that can carry a large amount of repair matrix and is easy to use and a method for producing the same can be provided.

A second aspect of the present disclosure provides a method of preparing an elastic dressing 1 carrying a repair matrix. The preparation method of the elastic dressing 1 carrying the repair matrix according to the second aspect of the present disclosure may be simply referred to as "preparation method of dressing" or "preparation method", and may also be referred to as preparation method of the elastic dressing 1, preparation method of repair dressing, preparation method of wound dressing, or the like.

Fig. 11 is a flowchart showing a method of manufacturing the elastic dressing 1 according to an example of the present disclosure.

The preparation method of the present disclosure comprises: preparing a support layer 20 having elasticity, the support layer 20 having a lower surface 22 facing the target surface when applied, an upper surface 21 opposite to the lower surface 22; transversely stretching the bearing layer 20 to enable the bearing layer 20 to be in a stretched state; processing the lower surface 22 of the carrier layer 20 in a stretched state to form a plurality of accommodating parts 23 having accommodating spaces, the accommodating parts 23 being grooves recessed from the lower surface 22 toward the upper surface 21, the grooves having openings 24 located at the lower surface 22; filling the accommodating space with a repair matrix through the opening 24, wherein the repair matrix is in a dry powder form; the stretching of the carrier layer 20 is stopped, the carrier layer 20 is retracted to a natural state and the openings 24 are closed to hold the repair matrix in the receiving space, resulting in the elastic dressing 1 (see fig. 11). The elastic dressing 1 manufactured by the manufacturing method according to the second aspect of the present disclosure is consistent with the elastic dressing 1 according to the first aspect of the present disclosure, and the detailed description of the elastic dressing 1 may refer to the description of the elastic dressing 1 above, and will not be repeated here.

In the production method according to the second aspect of the present disclosure, the opening 24 of the accommodating portion 23 may be directed upward, and the repair matrix may be filled into the accommodating space through the opening 24. In this case, it is possible to make the healing matrix slide down to the bottom of the accommodation space (i.e., the end of the accommodation portion 23 facing the upper surface 21) by its own weight, thereby facilitating filling of the accommodation space with the healing matrix to have a predetermined density so as to facilitate holding by applying pressure thereto by the inner wall of the accommodation portion 23.

In some examples, stretching the carrier layer 20 in the transverse direction may refer to stretching the edges of the carrier layer 20 by a plurality of external pulling forces parallel to the upper surface 21 or the lower surface 22 of the carrier layer 20 and directed towards the outside of the carrier layer 20. In some examples, the plurality of external pulling forces may be oppositely disposed. For example, when the amount of external pulling force is 2, the directions of the 2 external pulling forces may be set to be directed from the center of the carrier layer 20 to the outside of the carrier layer 20 and the directions of the 2 external pulling forces are opposite. This allows the support layer 20 to be stretched relatively uniformly, thereby facilitating filling of the plurality of storage portions 23 with the repair matrix.

In some examples, when the repair matrix is filled into the receiving space via the opening 24, the filling amount of the repair matrix may be determined according to the elastic modulus of the bearing layer 20 and the size of the receiving space of the bearing layer 20 in a natural state. Thereby, filling of the accommodating space with an appropriate amount of repair matrix can be facilitated.

In some examples, when filling the repair matrix into the accommodation space via the opening 24, the volume of the filled repair matrix may be slightly larger than the volume of the accommodation space of the carrier layer 20 in a natural state. Since the carrying layer 20 has elasticity, the accommodating portion 23 also has elasticity, in which case the accommodating portion 23 can accommodate the repair substrate having a volume larger than that of the accommodating space of the carrying layer 20 in a natural state, and the inner wall of the accommodating portion 23 can generate pressure toward the inside of the accommodating space to the repair substrate in the accommodating space, thereby being capable of facilitating the repair substrate to be more stably held in the accommodating space.

In some examples, the spill plate may be covered at the openings 24 during the process of stopping the stretching of the carrier layer 20, retracting the carrier layer 20 to a natural state, and collapsing the openings 24 to hold the repair matrix within the receiving space. The receiving space is also compressed during the retraction of the carrier layer 20 from the stretched state to the natural state, in which case by covering the spill plate at the opening 24, the repair matrix can be effectively prevented from overflowing from the opening 24 under the pressing action of the inner wall of the receiving portion 23. In some examples, the spill plate may be removed when the carrier layer 20 is retracted to a natural state and the repair matrix in the receptacle 23 remains stable under the pressure of the inner wall of the receptacle 23.

In some examples, after stopping stretching of the carrier layer 20 and retracting the carrier layer 20 to a natural state, the elastic dressing 1 may be placed and stored with the opening 24 facing upward. Thereby, the repair matrix can be more stably carried on the elastic dressing 1 during storage of the elastic dressing 1.

In summary, in the second aspect of the present disclosure, by using this production method, an elastic dressing 1 that mounts a large amount of repair matrix and is easy to use can be obtained.

While the disclosure has been described in detail in connection with the drawings and embodiments, it should be understood that the foregoing description is not intended to limit the disclosure in any way. Modifications and variations of the present disclosure may be made as desired by those skilled in the art without departing from the true spirit and scope of the disclosure, and such modifications and variations fall within the scope of the disclosure.

Claims

1. An elastic dressing for carrying a repair matrix, the elastic dressing comprising a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of accommodating parts having accommodating spaces for accommodating the repair matrix, the accommodating parts being grooves recessed from the lower surface toward the upper surface, the grooves having openings in the lower surface, the repair matrix being in a dry powder form and being in the accommodating spaces, the carrier layer having a natural state and a stretched state, the openings being in a collapsed state to hold the repair matrix in the accommodating spaces when the carrier layer is in the natural state, the openings being in an open state to release the repair matrix in the accommodating spaces when the carrier layer is in the stretched state;

The elastic dressing further comprises sealing films arranged on the lower surface, the sealing films are multiple in number and cover all openings respectively, when the bearing layer is in the natural state, the sealing films completely cover the openings, and when the bearing layer is in the stretching state, the sealing films at least incompletely cover the openings;

the region of the lower surface other than the opening is referred to as a first region, and the elastic dressing further includes a superhydrophobic structure disposed at the first region.

2. The elastic dressing of claim 1, wherein a natural widest internal diameter of said containment portion is from 0.5mm to 0.8mm when said carrier layer is in said natural state, and wherein a stretched widest internal diameter of said containment portion is from 150% to 300% of said natural widest internal diameter when said carrier layer is in said stretched state.

3. The elastic dressing of claim 1, wherein the receptacles are arranged in an array and adjacent two of the plurality of receptacles have a spacing of 3mm to 5mm when the carrier layer is in the natural state.

4. The elastic dressing of claim 1 wherein said carrier layer has super-hydrophilicity.

5. The elastic dressing of claim 1, wherein the superhydrophobic structure comprises a plurality of microscale protrusions disposed on the first region at intervals, and nanoparticles disposed on a surface of the microscale protrusions.

6. The elastic dressing of claim 1, further comprising an insulating layer having hydrophobicity, and wherein the insulating layer is disposed on the upper surface.

7. The elastic dressing of claim 6, wherein the elastic modulus of the barrier layer, the carrier layer, and the superhydrophobic structure are the same or similar.

8. A method for preparing an elastic dressing carrying a repair matrix, the method comprising: preparing a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface; transversely stretching the bearing layer to enable the bearing layer to be in a stretched state; machining the lower surface of the bearing layer in the stretched state to form a plurality of accommodating parts with accommodating spaces, wherein the accommodating parts are grooves which are concave from the lower surface to the upper surface, and the grooves are provided with openings positioned on the lower surface; filling the repair matrix into the accommodating space through the opening, wherein the repair matrix is in a dry powder form; stopping stretching the bearing layer, retracting the bearing layer to a natural state, and gathering the opening to keep the repair matrix in the accommodating space to obtain the elastic dressing; the elastic dressing further comprises sealing films arranged on the lower surface, the sealing films are multiple in number and cover all openings respectively, when the bearing layer is in the natural state, the sealing films completely cover the openings, and when the bearing layer is in the stretching state, the sealing films at least incompletely cover the openings; the region of the lower surface other than the opening is referred to as a first region, and the elastic dressing further includes a superhydrophobic structure disposed at the first region.