CN115737892A

CN115737892A - Elastic dressing carrying repair matrix and preparation method thereof

Info

Publication number: CN115737892A
Application number: CN202211454435.4A
Authority: CN
Inventors: 陈丽; 侯新国; 吕彬; 刘福强; 段武; 王海鹏; 和法莲; 高双; 吴蓉
Original assignee: Nolai Biomedical Technology Co ltd; Qilu Hospital of Shandong University
Current assignee: Nolai Biomedical Technology Co ltd; Qilu Hospital of Shandong University
Priority date: 2022-11-21
Filing date: 2022-11-21
Publication date: 2023-03-07

Abstract

The present disclosure describes an elastic dressing for carrying a repair substrate, which includes a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of receiving portions having receiving spaces for receiving the repair substrate, the receiving portions being recesses recessed from the lower surface to the upper surface, the recesses having openings at the lower surface, the repair substrate being in a dry powder form and being located in the receiving spaces, the carrier layer having a natural state and a stretched state, the openings being in a collapsed state to hold the repair substrate in the receiving spaces when the carrier layer is in the natural state, and the openings being in an open state to release the repair substrate in the receiving spaces when the carrier layer is in the stretched state. According to the present disclosure, an elastic dressing which can carry a large amount of repair matrix and is convenient to use can be provided. In addition, the disclosure also provides a preparation method for preparing the elastic dressing.

Description

Elastic dressing carrying repair matrix and preparation method thereof

Technical Field

The invention relates to the technical field of biomedical engineering, in particular to an elastic dressing carrying a repair matrix and a preparation method thereof.

Background

With the development of modern medical technology, people gradually realize that the wound healing is related to the environment of the wound in recent years, and the repair matrix with proper form and proper dosage is applied to the wound, so that the wound healing is facilitated.

The wound dressing is an article used for bandaging wounds, and can be used for carrying medicaments so as to repair the wound surface when in application. Traditional medical dressings usually spread the medicine on the surface of the dressing facing the wound surface, and the medicine is contacted with the surface of the wound surface when the dressing is applied; or the medicine is absorbed in the absorption layer of the dressing, and when the dressing is applied to the wound, the dressing can absorb the exudate of the wound, and the medicine can move to the wound through the molecular diffusion effect between liquids when being dissolved in the exudate; or mixing the medicine and carrier to form ointment, arranging the ointment on gauze, cotton, bandage, etc., and applying the dressing to the wound surface to make the medicine contact with the surface of the wound surface.

However, in the solution of spreading the medicine on the surface of the dressing facing the wound surface and then contacting the medicine with the surface of the wound surface during application, it is difficult to uniformly spread the medicine on the surface of the dressing, and the operation procedure is complicated because the medicine needs to be spread first and then applied; in the scheme of adsorbing the medicine in the adsorption layer of the dressing, the quantity of the medicine carried by the adsorption structure in the adsorption layer is often less, and the repair effect is not ideal; in the scheme that the medicine and the carrier agent are uniformly mixed to form the ointment and then the ointment is arranged on the dressing, the effective active factors in the ointment are less, and the wound repairing effect of the dressing can be influenced.

Disclosure of Invention

In view of the above-described conventional circumstances, an object of the present disclosure is to provide an elastic dressing that can be mounted with a large amount of a repair base and is easy to use, and a method for producing the same.

To this end, a first aspect of the present disclosure provides an elastic dressing for carrying a prosthetic substrate, comprising a carrier layer having elasticity, the carrier layer having a lower surface facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of receiving portions having receiving spaces for receiving the prosthetic substrate, the receiving portions being recesses recessed from the lower surface to the upper surface, the recesses having openings at the lower surface, the prosthetic substrate being in a dry powder form and being located in the receiving spaces, the carrier layer having a natural state and a stretched state, the openings being collapsed when the carrier layer is in the natural state to hold the prosthetic substrate in the receiving spaces, and the openings being open when the carrier layer is in the stretched state to release the prosthetic substrate in the receiving spaces.

In a first aspect of the present disclosure, an elastic dressing includes a carrier layer having elasticity, the carrier layer having a plurality of receiving portions having receiving spaces for receiving a repair substrate, the receiving portions having the receiving spaces therein can be made elastic by providing the carrier layer to have elasticity, thereby facilitating the receiving portions to receive a predetermined amount range of the repair substrate; by arranging the accommodating part in a groove shape which is concave from the lower surface to the upper surface, the repairing matrix can be conveniently filled in the accommodating part, and meanwhile, the accommodating part can better accommodate the repairing matrix; the repair matrix in a dry powder state per unit volume can contain more effective active factors than the repair matrix in a liquid state per unit volume, and in this case, the repair matrix is set to be in a dry powder state, so that the accommodating part can accommodate the repair matrix with more effective active factors, the wound healing can be facilitated, and meanwhile, the effective active factors can also have a longer storage life in the repair matrix in a dry powder state; the groove is provided with an opening positioned on the lower surface, the elastic dressing has a natural state and a stretching state, when the elastic dressing is in the natural state, the opening is in a furled state, the repairing matrix can be kept in the accommodating space through the furled opening, and meanwhile, the repairing matrix can be effectively separated from the external environment, so that the storage life of the repairing matrix can be prolonged; when the elastic dressing is in a stretching state, the opening is in an open state, and the repair matrix positioned in the accommodating space can be released to the outside through the open opening; when the target surface is a wound surface, applying the elastic dressing of the present disclosure to the wound surface enables the repair matrix to come into contact with the wound, thereby enabling the wound to be promoted to heal. Thus, with the elastic dressing of the present disclosure, a large number of repair substrates can be carried and the use is convenient.

Further, in the elastic dressing according to the first aspect of the present disclosure, optionally, when the carrier layer is in the natural state, a natural widest inner diameter of the receiving portion is 0.5mm to 0.8mm, and when the carrier layer is in the stretched state, a stretched widest inner diameter of the receiving portion is 150% to 300% of the natural widest inner diameter. In this case, when the shape of the receiving portion is determined, filling of a desired amount of the repair matrix into the receiving portion can be facilitated by adjusting the natural widest inner diameter of the receiving portion, and releasing of the repair matrix in the receiving space can be facilitated by stretching the stretched widest inner diameter of the receiving portion to 150% to 300% of the natural widest inner diameter, while the possibility of undesired deformation of the structure of the receiving portion and/or the carrier layer due to elastic deformation of the carrier layer beyond the elastic limit can be effectively reduced.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the plurality of receptacles are arranged in an array, and when the carrier layer is in the natural state, a distance between two adjacent openings of the plurality of receptacles is 3mm to 5mm. Under this condition, arrange the portion of holding through the array, can be favorable to repairing matrix and evenly release to the surface of a wound, through the interval of two adjacent openings in the opening of adjusting a plurality of portions of holding, can be convenient for control the density of the portion of holding in the bearer layer, can be convenient for from this control to the volume of the repair matrix of the surface of a wound release of unit area to be favorable to the healing of wound.

Further, in the elastic dressing according to the first aspect of the present disclosure, optionally, the carrier layer has super-hydrophilicity. In this case, when the elastic dressing is stretched and applied to the target surface having the liquid layer, part of the liquid on the region of the target surface corresponding to the opening enters the receiving portion through the opening and is absorbed by the carrier layer, so that the possibility of occurrence of dead wound space (i.e., cavity mainly composed of necrotic tissue) and/or wound infection due to accumulation of excessive exudate on the wound surface for a long time can be effectively reduced, thereby facilitating the healing of the wound.

In addition, in the elastic dressing according to the first aspect of the present disclosure, an area of the lower surface other than the opening is optionally referred to as a first area, and the elastic dressing further includes a superhydrophobic structure disposed on the first area. In this case, when the elastic dressing is stretched and applied to the target surface having the liquid layer, the liquid on the region of the target surface corresponding to the first region can be at least partially retained by the superhydrophobic structure disposed on the first region, so that the region of the target surface corresponding to the first region is in a wet environment, thereby providing a good healing environment for the wound surface, and furthermore, when the elastic dressing needs to be peeled off from the wound surface, since the region of the target surface corresponding to the first region is in a wet environment, the superhydrophobic performance on the surface of the superhydrophobic structure contacting the wound can make the superhydrophobic structure exhibit adhesion resistance to wound secretions and granulation tissue and the like on the wound surface, thereby reducing adhesion between the elastic dressing and the granulation tissue regenerated from the wound surface, making it easy to peel off from the wound surface, thereby reducing the possibility of the elastic dressing peeling off from the wound surface to cause secondary damage to the wound.

Further, in the elastic dressing according to the first aspect of the present disclosure, optionally, the superhydrophobic structure includes a plurality of micro-scale protrusions arranged on the first region at intervals, and nanoparticles disposed on surfaces of the micro-scale protrusions. Thereby, the hydrophobic property of the superhydrophobic structure can be enhanced.

Further, in the elastic dressing relating to the first aspect of the present disclosure, optionally, the elastic dressing further includes a release layer having hydrophobicity, and the release layer is provided on the upper surface. Under this condition, through the isolation layer that sets up the hydrophobicity at the upper surface of carrier layer, can effectively resist the pollutant among the external environment and get into the dressing, play the barrier effect to can effectively reduce the infection risk of the surface of a wound.

Further, in the elastic dressing according to the first aspect of the present disclosure, optionally, the elastic moduli of the isolation layer, the carrier layer, and the superhydrophobic structure are the same or similar. Under the condition, when the elastic dressing is stretched or the elastic dressing is stopped to be stretched and the elastic dressing is retracted to a natural state, the isolation layer, the bearing layer and the super-hydrophobic structure can be synchronously deformed, so that the phenomenon that the elastic dressing is undesirably deformed when being stretched and/or retracted due to the fact that the elastic modulus difference exists in the internal structure of the elastic dressing can be effectively avoided.

In addition, in the elastic dressing according to the first aspect of the present disclosure, optionally, the elastic dressing further includes a sealing film disposed on the lower surface, and the sealing film completely covers the plurality of openings when the carrier layer is in the natural state. Under the condition, the sealing film covers the opening, so that the storage stability of the repair matrix in the accommodating part can be improved, and the repair matrix is effectively prevented from being scattered to the outside through the opening when the bearing layer is in a natural state.

A second aspect of the present disclosure provides a method for preparing an elastic dressing carrying a repair matrix, wherein the method comprises: preparing a resilient carrier layer having a lower surface facing a target surface when applied, and an upper surface opposite the lower surface; transversely stretching the bearing layer to enable the bearing layer to be in a stretching state; processing the lower surface of the bearing layer in the stretching state to form a plurality of accommodating parts with accommodating spaces, wherein the accommodating parts are grooves which are concave from the lower surface to the upper surface, and the grooves are provided with openings positioned on the lower surface; filling the repair matrix into the receiving space via the opening, the repair matrix being in a dry powder form; stopping the stretching of the carrier layer, retracting the carrier layer to a natural state and the opening to collapse to retain the repair matrix within the containment space, resulting in the elastic dressing. In the second aspect of the present disclosure, by preparing an elastic dressing by the preparation method, an elastic dressing that can carry a large amount of a repair substrate and is convenient to use can be obtained.

According to the present disclosure, an elastic dressing that can carry a large amount of repair base and is convenient to use, and a method for manufacturing the same can be provided.

Drawings

Fig. 1 is a schematic diagram illustrating a first embodiment of an elastic dressing according to examples of the present disclosure.

Fig. 2 is a schematic sectional view showing an elastic dressing according to an example of the present disclosure in a natural state.

Fig. 3 is a schematic cross-sectional view showing an elastic dressing according to an example of the present disclosure in a stretched state.

Fig. 4 is a schematic structural view showing a housing part according to an example of the present disclosure.

Fig. 5 is a schematic structural view showing another embodiment of a housing part according to an example of the present disclosure.

Fig. 6 is a schematic diagram showing a housing-mounted repair substrate according to an example of the present disclosure.

Fig. 7 is a schematic diagram illustrating a containment release repair matrix according to an example of the present disclosure.

Fig. 8 is a schematic diagram illustrating a receptacle releasing a repair matrix to a target surface according to an example of the present disclosure.

Fig. 9 is a schematic diagram illustrating a superhydrophobic structure according to an example of the present disclosure.

Fig. 10 is a schematic diagram illustrating another embodiment of an elastic dressing according to examples of the present disclosure.

Fig. 11 is a flow chart illustrating a method of making an elastic dressing in accordance with examples of the present disclosure.

Description of reference numerals:

1 method 8230, an elastic dressing 10 method 8230, an ultra-hydrophobic structure 11 method 8230, micron-sized protrusions 12 method 8230, nanoparticles 20 method 8230, a bearing layer 21 method 8230, an upper surface 22 method 8230, a lower surface 23 method 8230, an accommodating part 231 method 8230, a lower half part 232 method 8230, an upper half part 24 method 8230, an opening 25 method 8230, a sealing film 30 method 8230, an isolation layer 40 method 8230, a first protection film 50 method 8230, a second protection film 9 method 8230, a wound surface 90 method 8230, a liquid layer S8230and a first area.

Detailed Description

All references cited in this disclosure are incorporated by reference in their entirety as if fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same components are denoted by the same reference numerals, and redundant description thereof is omitted. The drawings are schematic, and the proportions of the dimensions of the components and the shapes of the components may be different from the actual ones.

A first aspect of the present disclosure relates to an elastic dressing carrying a repair matrix, which is a dressing that can be used to protect and repair a target surface. The elastic dressing carrying the repair matrix according to the first aspect of the present disclosure may be simply referred to as "elastic dressing" or "dressing", and may also be referred to as dressing carrying the repair matrix, drug delivery dressing, repair dressing, wound dressing, or the like. According to the elastic dressing, a proper amount of repair matrix can be uniformly provided for a wound surface.

In the present disclosure, the target surface may be a wound surface. The wound surface is a lesion caused by injury to normal skin (tissue), and may be a wound caused by conditions such as scald, abrasion, cut wound, sprain, ulcer, and cold injury. That is, the wound bed may refer to the surface of a wound. In other examples, the target surface may also be other surfaces, such as a skin surface. It is noted that the elastic dressing according to the present disclosure may also be applied as a protective layer to, for example, a semi-healed wound that has scabbed and dried.

Hereinafter, an elastic dressing according to the present disclosure will be described with reference to the drawings, taking a target surface as an example of a wound surface.

Fig. 1 is a schematic diagram showing a first embodiment of an elastic dressing 1 according to examples of the present disclosure. Fig. 2 is a schematic sectional view showing an elastic dressing 1 according to an example of the present disclosure in a natural state. Fig. 3 is a schematic sectional view showing an elastic dressing 1 according to an example of the present disclosure in a stretched state.

In some examples, the elastic dressing 1 may include a carrier layer 20 (see fig. 1). In some examples, the carrier layer 20 may have a plurality of receiving portions 23 (see fig. 2) having receiving spaces for receiving the repair matrix. In this case, the carrier layer 20 can accommodate a large amount of the repair base material by the plurality of accommodating portions 23 provided on the carrier layer 20, and thus it is advantageous to promote recovery of the wound surface 9 during use.

In some examples, the carrier layer 20 may have a lower surface 22 that faces the target surface when applied, and an upper surface 21 opposite the lower surface 22 (see FIG. 2). In some examples, the receiving portion 23 may be a groove recessed toward the upper surface 21 from the lower surface 22 (see fig. 2). In this case, by providing the accommodating portion 23 in a recessed form recessed from the lower surface 22 toward the upper surface 21, filling of the accommodating portion 23 with the repair matrix can be facilitated, while the accommodating portion 23 can be made to accommodate the repair matrix better. In some examples, the recess may have an opening 24 in the lower surface 22. In this case, the opening 24 allows the repair matrix to be transferred inside and outside the housing portion 23.

In some examples, the repair matrix may be located within the containment space. This makes it possible to facilitate the mounting of the repair base on the elastic dressing 1. In some examples, the repair matrix may be in a dry powder form. The repair matrix in dry powder form can contain a higher concentration of active factors than the repair matrix in liquid/gel form, in other words, the repair matrix in dry powder form per unit volume can contain more active factors than the repair matrix in liquid form per unit volume, in which case, by setting the repair matrix in dry powder form, the accommodating portion 23 can be made to accommodate the repair matrix with more active factors, so that the healing of the wound surface 9 can be facilitated, and at the same time, the active factors can also have a longer shelf life in the repair matrix in dry powder form.

In some examples, the carrier layer 20 may be elastic. In some examples, the load bearing layer 20 may have a natural state and a stretched state (see fig. 2, 3). The openings 24 may be in a collapsed condition when the load bearing layer 20 is in its natural condition (see fig. 2). The openings 24 may be open when the carrier layer 20 is in a stretched state (see fig. 3). In this case, the collapsed opening 24 allows the repair matrix to be retained within the containment space while being effectively isolated from the external environment, thereby facilitating extended shelf life of the repair matrix; the repair matrix in the accommodating space can be released to the outside through the open opening 24 by stretching the carrier layer 20, and when the target surface is the wound surface 9, the repair matrix can be released to the wound surface 9, so that the repair matrix is in contact with the wound, and the wound healing can be promoted.

It should be noted that, in the present disclosure, the natural state of the bearing layer 20 may refer to a state that the bearing layer 20 assumes when it is not affected by an external force. The tensile state of the load bearing layer 20 may refer to a state in which the load bearing layer 20 is deformed by an external tensile force. For example, the carrier layer 20 may be stretched laterally to open the openings 24. In the example shown in fig. 3, the left and right ends of the bearing layer 20 are respectively subjected to external tensile forces in the left and right directions (D1 and D2 directions shown in fig. 3), and the openings 24 are changed from the closed state shown in fig. 2 to the open state shown in fig. 3. In some examples, a plurality of external tensile forces may also be applied to the carrier layer 20 along a direction parallel to the upper surface 21 or the lower surface 22 of the carrier layer 20 and directed outward of the carrier layer 20 to stretch it to a predetermined configuration. In some examples, the plurality of external pulling forces may be oppositely disposed. For example, when the number of external tensile forces is 2, the direction of the 2 external tensile forces may be set to be directed from the center of the carrier layer 20 to the outside of the carrier layer 20 and the direction of the 2 external tensile forces is opposite. This can facilitate uniform stretching of the carrier layer 20.

In some examples, the natural widest inner diameter of the receptacle 23 may be 0.5mm to 0.8mm when the load bearing layer 20 is in a natural state. In this case, when the shape of the accommodating portion 23 is determined, the volume of the accommodating space can be adjusted by adjusting the natural widest inner diameter of the accommodating portion 23, whereby it is possible to facilitate filling of the accommodating portion 23 with a desired amount of the repair matrix.

In some examples, the stretched widest inner diameter of the pocket 23 may be 150% to 300% of the natural widest inner diameter when the load bearing layer 20 is in a stretched state. In this case, by stretching the carrier layer 20, the release of the repair matrix in the receiving space can be facilitated, while the probability of undesired deformation of the structure of the carrier layer 20 and/or the receiving portion 23 due to elastic deformation of the carrier layer 20 beyond the superelastic limit can be effectively reduced.

In some examples, the plurality of receptacles 23 may be arranged in an array. This can facilitate a uniform release of the repair matrix in the receptacle 23 to the wound surface 9. In some examples, when the bearing layer 20 is in a natural state, a distance between two adjacent openings 24 among the openings 24 of the plurality of receiving portions 23 may be 3mm to 5mm. In this case, by adjusting the distance between two adjacent openings 24 of the plurality of receiving portions 23, the density of the receiving portions 23 in the carrier layer 20 can be easily controlled, and thus the amount of the repair matrix released to the wound surface 9 per unit area can be easily controlled, thereby facilitating the healing of the wound.

Fig. 4 is a schematic structural view showing the accommodating portion 23 according to an example of the present disclosure.

In some examples, the receptacle 23 may be substantially ellipsoidal (see fig. 4). In this case, by providing the accommodating portions 23 with a relatively regular shape, it is possible to facilitate processing of the carrier layer 20 to form the accommodating portions 23; meanwhile, when the elastic dressing 1 is in a natural state, the inner wall of the ellipsoidal accommodating part 23 can more uniformly generate pressure towards the inside of the accommodating space for the repairing matrix in the accommodating space, so that the repairing matrix can be more stably kept in the accommodating space.

In some examples, the receptacle 23 may be ellipsoidal with an opening 24 at the bottom (see fig. 4). In this case, by disposing the opening 24 at the bottom of the accommodating portion 23, when the carrier layer 20 is in a natural state, the bottom of the accommodating portion 23 can be made to assume a shape gathered from the periphery toward the center, and the repair matrix can be further stably held; since the inner wall of the accommodating portion 23 has a smoothly curved shape, when the support layer 20 is in a stretched state to release the repair matrix, it is possible to facilitate guiding the repair matrix to be transferred from the opening 24 to the outside.

Fig. 5 is a schematic structural view showing another embodiment of the accommodating portion 23.

In some examples, the lower half 231 of the receptacle 23 may be semi-ellipsoidal with the opening 24, and the upper half 232 of the receptacle 23 may be cylindrical to match the lower half 231 (see fig. 5). In some examples, the upper half 232 of the receptacle 23 may mate with the lower half 231 meaning that the upper half 232 of the receptacle 23 engages the lower half 231. In this case, the bottom of the containing part 23 is in a shape folded from the periphery to the center, and meanwhile, the cylindrical upper half part 232 has a larger containing space than the semi-ellipsoidal upper half part 232, so that the cylindrical upper half part 232 can contain more repairing matrixes, and the matching of the upper half part 232 and the lower half part 231 of the containing part 23 can enable the elastic dressing 1 to carry more repairing matrixes and smoothly release the repairing matrixes in a stretching state, thereby being capable of better adapting to the requirements in different scenes. The present disclosure is not limited thereto, and the shape of the accommodating portion 23 may be adjusted according to actual needs, for example, the accommodating portion 23 may have an inverted conical shape with an opening 24 at the bottom. In some examples, the receptacle 23 may be any regular or irregular shape having an opening 24 with a closed configuration at the bottom.

Fig. 6 is a schematic diagram showing the housing 23 carrying the repair substrate according to the example of the present disclosure. Fig. 7 is a schematic view showing that the accommodation portion 23 releases the repair matrix according to an example of the present disclosure. In fig. 7, the arrow schematically indicates the moving direction of the repair matrix.

In some examples, the elastic dressing 1 may further include a sealing film 25 disposed on the lower surface 22 (see fig. 6). The sealing film 25 may completely cover the plurality of openings 24 when the carrier layer 20 is in a natural state. In this case, the sealing film 25 covers the opening 24, so that the storage stability of the repair base material in the housing portion 23 can be improved, the repair base material can be effectively prevented from being scattered to the outside through the opening 24 when the support layer 20 is in a natural state, and the contact between the repair base material in the housing portion 23 and the external environment can be reduced, thereby prolonging the storage life.

In some examples, the number of the sealing films 25 may be plural, and each sealing film 25 may cover each opening 24, respectively. When the carrier layer 20 is in a stretched state, the inner diameter of the opening 24 is widened, and the sealing film 25 at least does not completely cover the opening 24, and at this time, the internal space of the container 23 can communicate with the outside through the opening 24. Thereby, the repair matrix in the accommodation portion 23 can be released through the opening 24 in a stretched state.

In some examples, the sealing film 25 may be separated from the opening 24 when the carrier layer 20 is in a stretched state. In other words, the sealing film 25 may be completely detached from the opening 24. In this case, the transfer of the repair substrate to the outside through the opening 24 can be facilitated.

Referring to fig. 6 and 7, when the carrier layer 20 is in a natural state, the sealing film 25 may completely cover the opening 24; when the carrier layer 20 is in a stretched state, the inner diameter of the opening 24 is widened, the sealing film 25 can be separated from the opening 24, and the repair matrix located in the receptacle 23 can be transferred to the outside through the opening 24.

In some examples, the sealing film 25 may also be a unitary sheet and completely cover the lower surface 22 of the carrier layer 20. In this case, the sheet sealing film 25 covering the lower surface 22 can completely cover each opening 24, improving the storage stability of the repair base material in the housing portion 23; further, the operation of applying the sealing film 25 to cover each opening 24 can be simplified as compared with the case where a plurality of sealing films 25 are provided.

In some examples, the unitary sheet of sealing film 25 may not completely cover all of the opening 24 when the carrier layer 20 is in a stretched state. In this case, the carrier layer 20 is stretched, that is to say the elastic dressing 1 is also stretched, the entire sheet-like sealing film 25 is broken under the effect of the stretching, and the repair matrix in the receptacle 23 can be released via the opening 24, since the opening 24 is no longer covered by the sealing film 25 and the inner diameter of the opening 24 is widened under the effect of the stretching.

In some examples, a unitary piece of sealing film 25 may be detachably disposed on the lower surface 22 of the carrier layer 20. Before use, the sealing film 25 may be peeled off the lower surface 22 and the carrier layer 20 may be stretched to release the healing matrix.

In some examples, the sealing film 25 may be water soluble. In this case, the sealing film 25, when in contact with the exudate on the wound bed 9, is capable of dissolving in the exudate, thereby facilitating the release of the repair matrix located in the containment space.

In some examples, the sealing film 25 may include a substance that facilitates promoting wound healing. For example, the composition of the sealing film 25 may be similar or identical to the composition of the repair matrix. In this case, it is possible to promote the healing of the wound surface 9.

In some examples, the carrier layer 20 may have a superhydrophilic property. In this case, when the elastic dressing 1 is stretched and the elastic dressing 1 is applied to the target surface having the liquid layer 90, a part of exudate on the region of the target surface corresponding to the opening 24 enters the receiving portion 23 through the opening 24 and is absorbed by the support layer 20, thereby effectively reducing the possibility of occurrence of dead wound space (i.e., a cavity mainly composed of necrotic tissue) and/or wound infection due to accumulation of excessive exudate on the wound surface 9 for a long time, and thus facilitating the healing of the wound.

In some examples, the region on the lower surface 22 other than the opening 24 may be referred to as a first region S (see fig. 2). In some examples, the elastic dressing 1 may further include a superhydrophobic structure 10 disposed at the first region S (see fig. 2). In this case, when stretching the elastic dressing 1 and applying the elastic dressing 1 to the target surface having the liquid layer 90, the liquid on the region of the target surface corresponding to the first region S can be at least partially retained by the superhydrophobic structure 10 provided on the first region S, so that the region of the target surface corresponding to the first region S is in a wet environment, thereby being able to provide a suitable healing environment for the wound bed 9. In addition, when the elastic dressing 1 needs to be peeled off from the wound surface 9, since the region of the target surface corresponding to the first region S is in a proper humid environment, the superhydrophobic performance on the surface of the superhydrophobic structure 10 contacting with the wound can enable the superhydrophobic structure to play an anti-adhesion role on wound secretions, granulation tissues and the like on the surface of the wound, so that adhesion between the elastic dressing 1 and the regenerated granulation tissues of the wound can be reduced, the elastic dressing can be easily peeled off from the wound surface 9, and the possibility of secondary injury to the wound caused by peeling of the elastic dressing 1 from the wound surface 9 can be reduced.

It should be noted that, in the present disclosure, providing a suitable moist environment/healing environment for the wound surface 9 means that the wound surface 9 can be moistened without being soaked in a liquid by the elastic dressing 1 of the present disclosure.

In some examples, the sealing film 25 may be disposed on a surface of the superhydrophobic structure 10 relatively distant from the carrier layer 20. In some examples, the area of the sealing film 25 may be no less than the area of the surface of the superhydrophobic structure 10 and the sealing film 25 can completely cover the surface of the superhydrophobic structure 10. This can further improve the stability of holding the repair substrate in the housing portion 23.

In some examples, when it is desired to apply the elastic dressing 1 to the wound bed 9, the elastic dressing 1 may be stretched prior to applying the elastic dressing 1 in the stretched state to the wound bed 9. In this case, the open opening 24 enables the repair matrix located in the receiving space to be released continuously to the wound bed 9, promoting wound healing. In some examples, the opening 24 of the receptacle 23 may be applied to the wound bed 9 in an upwardly facing configuration during stretching of the elastic dressing 1 and application of the elastic dressing 1 in the stretched state to the wound bed 9. In this case, by orienting the opening 24 of the accommodation portion 23 upward, the prosthetic substrate can be effectively prevented from spilling from the accommodation space to the outside during the stretching of the elastic dressing 1.

In some examples, when it is desired to apply the elastic dressing 1 to the wound surface 9, the elastic dressing 1 may be stretched with the opening 24 of the receptacle 23 facing the wound surface 9 to partially release the repair matrix to the wound surface 9, then the stretching of the elastic dressing 1 is stopped, the elastic dressing 1 is retracted to a natural state, and then the elastic dressing 1 is applied to the wound surface 9. In this case, after the part of the repair matrix is released to the wound surface 9, the amount of the remaining repair matrix in the receiving portion 23 decreases, and the overall density decreases, at which time even if the elastic dressing 1 rebounds to the natural state, the inner wall of the receiving portion 23 no longer exerts a pressure on the remaining repair matrix sufficient to keep it in the receiving space, and when the elastic dressing 1 in the natural state is applied to the wound surface 9, the repair matrix in the receiving portion 23 can be gradually transferred to the wound surface 9 through the opening 24; simultaneously can effectively reduce the condition that the elastic dressing 1 makes the surface of a wound 9 that is applied with the dressing shrink, the skin that is applied with the dressing beyond the surface of a wound 9 is tightened because of the rebound effect after being applied with the surface of a wound 9, thereby improving the use comfort of the elastic dressing 1.

Fig. 8 is a schematic diagram illustrating the receptacle 23 releasing the repair matrix to the target surface according to an example of the present disclosure. In fig. 8, the arrow schematically indicates the moving direction of the repair matrix.

In some examples, the superhydrophobic structure 10 may be in contact with the wound bed 9 when the elastic dressing 1 is applied to the wound bed 9 (see fig. 8). In some examples, a liquid layer 90 (see fig. 8) of exudate secreted by the wound bed 9 may be present between the wound bed 9 and the first area S of the superhydrophobic structure 10. In this case, by providing a suitable moist environment for the wound bed 9, wound healing can be facilitated.

In some examples, the repair matrix may be water soluble. In this case, when the elastic dressing 1 in a stretched state is applied to the wound surface 9, the repair matrix can be released to the wound surface 9, and the repair matrix can dissolve in exudate on the wound surface 9 to repair the wound surface 9 by contacting the wound surface 9. In some examples, the repair matrix may diffuse through liquid layer 90 to the area of wound bed 9 corresponding to first region S. This can facilitate healing of the wound surface 9. In some examples, the sealing film 25 may also have water solubility.

In some examples, the repair matrix may move downward by osmosis after spreading into the area of the wound bed 9. It is understood that the repair matrix can move downward by osmosis, which means that the repair matrix can move from the wound bed 9 to deep in the skin by osmosis. This can further promote the healing of the wound.

In some examples, when the repair matrix dissolves in the exudate, excess exudate on the area of the wound bed 9 corresponding to the opening 24 may also move into the receptacle 23 by osmosis in the repair matrix. The bearing layer 20 has super-hydrophilicity, that is, the inner wall of the accommodating portion 23 also has super-hydrophilicity, and redundant exudate can be absorbed by the bearing layer 20 by moving to the accommodating portion 23 and contacting with the inner wall of the accommodating portion 23, so that the possibility of wound dead space (i.e. cavity mainly containing necrotic tissue) and/or wound infection caused by the accumulation of excessive exudate on the wound surface 9 for a long time can be effectively reduced, and the wound healing is facilitated.

In some examples, the repair matrix may include mesenchymal stem cells and/or derivatives of mesenchymal stem cells. For example, in some examples, the repair matrix may include a supernatant of mesenchymal stem cells. The supernatant of the mesenchymal stem cells contains a substance capable of promoting wound healing, in which case healing of the wound can be facilitated when the repair matrix is in contact with the wound bed 9.

In some examples, the repair matrix may be in the form of a lyophilized powder. In this case, compared with the stem cell supernatant existing in a liquid state, the concentration of the effective active cytokine in the unit volume of the lyophilized stem cell supernatant is higher, and the preservation period of the bioactive substance is longer, and when the lyophilized mesenchymal stem cell supernatant is carried on the carrier layer 20, the elastic dressing 1 of the present disclosure can be conveniently stored and clinically applied.

In some examples, mesenchymal stem cell-derived exosomes may be included in the supernatant of mesenchymal stem cells. Among them, exosomes are extracellular vesicles containing complex RNAs and proteins secreted by cells. Under the condition, the exosome derived from the mesenchymal stem cells can promote the healing of the wound surface 9 by using the paracrine effect, inhibit the inflammatory reaction of the wound surface 9, promote the angiogenesis, improve the extracellular matrix environment, mobilize the cells of the organism to migrate to the damaged part, and repair the wound surface 9.

In some examples, the supernatant of the mesenchymal stem cells may further include one or more of vascular endothelial growth factor, epidermal growth factor, transforming growth factor-beta, liver growth factor, superoxide dismutase, interleukin-6, collagen, fibronectin, and platelet-derived factor. In this case, the healing of the wound can be advantageously promoted by the prosthetic matrix.

In some examples, the supernatant of the mesenchymal stem cells may include one or more of exosomes of mesenchymal stem cells, vascular endothelial growth factor, epidermal growth factor, transforming growth factor-beta, liver growth factor, superoxide dismutase, interleukin-6, collagen, fibronectin, and platelet-derived factor. In this case, the repair ability of the repair matrix can be further improved, thereby promoting wound healing.

The present disclosure is not limited thereto, and the corresponding repair matrix may be selected according to the actual condition of the wound surface 9. For example, in some examples, the repair matrix may also include other components that aid in wound healing. For example, the repair matrix may also include a hemostatic powder, and the like.

In some examples, the mesenchymal stem cell may be an umbilical cord mesenchymal stem cell, a bone marrow mesenchymal stem cell, or an adipose mesenchymal stem cell. The repair matrix may include a plurality of mesenchymal stem cells and/or derivatives of mesenchymal stem cells. That is, in some examples, the repair matrix may include derivatives of one or more of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, and adipose mesenchymal stem cells. Under the condition, various mesenchymal stem cells and derivatives thereof can be beneficial to wound healing, have rich sources, and can conveniently adjust the components of the repair matrix according to actual needs.

In some examples, the medicament may be applied to the wound bed 9 before the elastic dressing 1 is applied to the wound bed 9, and the elastic dressing 1 is then applied to the wound bed 9. The components of the medicine can be the same as those of the repairing matrix, and can also be other components capable of promoting wound healing. In this case, the repair matrix can be used in combination with a drug to further improve the ability of the repair to the wound, thereby promoting wound healing.

For example, in some examples, the composition of the drug may also include exosomes of umbilical cord mesenchymal stem cells, and the drug may also be present in the form of a lyophilized powder, at which time the drug may be uniformly sprinkled on the wound surface 9 before the elastic dressing 1 is applied to the wound surface 9. Under the condition, the exosome of the umbilical cord mesenchymal stem cells can exert the biological effect of the umbilical cord mesenchymal stem cells, and the wound surface 9 is promoted to heal.

Fig. 9 is a schematic diagram illustrating a superhydrophobic structure 10 according to an example of the present disclosure. Fig. 9 is an enlarged view of a region a in fig. 6.

In some examples, the superhydrophobic structure 10 may include a plurality of micro-scale protrusions 11 arranged on the first region S at intervals, and nanoparticles 12 disposed on surfaces of the micro-scale protrusions 11 (see fig. 9). In this case, when the liquid droplet contacts the surface of the superhydrophobic structure 10, due to the existence of the micro-scale protrusions 11 and the nano-particles 12, an air film is formed between the liquid droplet and the surface of the superhydrophobic structure 10, so as to hinder the liquid from wetting the surface of the superhydrophobic structure 10, and thus a superhydrophobic state can be formed, so that the surface of the superhydrophobic structure 10 has superhydrophobicity. In the present disclosure, the superhydrophobic structure 10 including the micro-scale protrusions 11 and the nanoparticles 12 may also be referred to as a micro-nano structure.

In some examples, the micro-scale protrusions 11 may be in the shape of mastoids, cones, or columns. In some examples, the height of the micro-scale protrusions 11 is 20 μm to 150 μm. In this case, it is possible to advantageously improve the hydrophobic property of the superhydrophobic structure 10, thereby facilitating maintenance of a wet environment, and easy peeling.

In some examples, the micro-scale protrusions 11 may be arranged in an array. In some examples, the pitch of two adjacent micro-scale protrusions 11 may be 20 μm to 200 μm. In this case, the hydrophobic property of the superhydrophobic structure 10 is relatively uniform, and the thickness of the liquid layer 90 formed by the liquid held between the superhydrophobic structure 10 and the wound surface 9 is substantially uniform, so that the healing speed of the wound surface 9 corresponding to the superhydrophobic structure 10 tends to be uniform, which is beneficial to healing of the wound surface 9.

In some examples, the nanoparticles 12 may have a particle size in the range of 50nm to 1000nm. The particle size range refers to the diameter of the nanoparticles 12 when they are spherical, and refers to the equivalent diameter of the three-dimensional structure when they are not spherical. In some examples, the number of nanoparticles 12 may be plural, and the particle size and shape of the plural nanoparticles 12 may be the same or different (see fig. 9).

In some examples, the contact angle of the micro water drop on the surface of the superhydrophobic structure 10 may be greater than 150 ° and the rolling angle is less than 10 °. In this case, the superhydrophobic structure 10 has superhydrophobic performance, and by providing the superhydrophobic structure 10 in the first area S, the moist environment between the first area S and the wound surface 9 can be maintained, and the elastic dressing 1 is easily peeled off from the wound surface 9.

In some examples, the thickness of the superhydrophobic structure 10 can be 0.1mm to 2mm. It should be noted that, in the present disclosure, the thickness of the superhydrophobic structure 10 is the thickness including the micro-scale protrusions 11 and the nanoparticle 12 as a whole. In this case, the superhydrophobic structure 10 is moderately thin and thick, can maintain good air permeability, and can also facilitate migration of exudate into the receiving portion 23 by permeation in the repair matrix to be absorbed by the carrier layer 20 having superhydrophilic properties. In some examples, the thickness of the superhydrophobic structure 10 may be 0.1mm to 1mm, preferably.

In some examples, the superhydrophobic structure 10 can be composed of a hydrophobic material. In some examples, the material of the superhydrophobic structure 10 can be a silica gel. In some examples, the superhydrophobic structure 10 can be a silicone rubber film, which can also be referred to as a PDMS (polydimethylsiloxane) film. In this case, the superhydrophobic structure 10 is soft in texture and has good biocompatibility and air permeability, and is non-irritating to human tissue, and can be beneficial to healing of the wound surface 9.

In some examples, the elastic dressing 1 may further include a barrier layer 30 having hydrophobicity. In some examples, the isolation layer 30 may be disposed on the upper surface 21 of the carrier layer 20 (see fig. 1). In this case, by arranging the hydrophobic isolation layer 30 on the upper surface 21 of the bearing layer 20, the contaminants in the external environment can be effectively prevented from entering the dressing, so as to play a role of a barrier, and thus, the infection risk of the wound surface 9 can be effectively reduced.

In some examples, the elastic moduli of the isolation layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be the same or similar. In some examples, the elastic moduli of the separation layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be similar in meaning that the elastic moduli of any two of the separation layer 30, the carrier layer 20, and the superhydrophobic structure 10 differ by no more than 10% above or below. For example, the elastic moduli of any two of the separator layer 30, the carrier layer 20, and the superhydrophobic structure 10 may differ by 1%, 2%, 5%, 8%, or 10%. In this case, when the elastic dressing 1 is stretched or the elastic dressing 1 is stopped from being stretched to retract the elastic dressing 1 to the natural state, the isolation layer 30, the carrier layer 20, and the superhydrophobic structure 10 can be deformed synchronously, so that undesired deformation of the elastic dressing 1 during stretching and/or retraction due to the difference of the elastic modulus of the internal structure of the elastic dressing 1 can be effectively avoided.

In some examples, adjacent two of the release layer 30, the carrier layer 20, and the superhydrophobic structure 10 may be bonded to each other by an adhesive, and no adhesive is disposed in regions of the carrier layer 20 corresponding to the openings 24. In this case, the layers can be tightly bonded to each other and the elastic dressing 1 is facilitated to release the repair matrix through the opening 24.

Fig. 10 is a schematic diagram illustrating another embodiment of an elastic dressing 1 according to examples of the present disclosure.

In some examples, the elastic dressing 1 may further include a first protective film 40 (see fig. 10) that peelably covers a surface of the superhydrophobic structure 10. In this case, by providing the first protective film 40, the surface of the superhydrophobic structure 10 can be maintained in a clean state before being used, and when the elastic dressing 1 needs to be attached to the wound surface 9, the first protective film 40 may be peeled off from the surface of the superhydrophobic structure 10.

In some examples, the shape of the first protective film 40 may match the shape of the surface of the superhydrophobic structure 10. In some examples, the shape of the first protective film 40 may match the shape of the surface of the superhydrophobic structure 10 means that the area of the first protective film 40 is not smaller than the area of the surface of the superhydrophobic structure 10 and the first protective film 40 can completely cover the surface of the superhydrophobic structure 10. Thereby, the first protection film 40 can be enabled to better protect the superhydrophobic structure 10.

In some examples, the elastic dressing 1 may further include a second protective film 50 (see fig. 10) releasably covering a surface of the barrier layer 30 relatively remote from the carrier layer 20. In this case, the surface of the isolation layer 30 relatively far from the bearing layer 20 can be maintained in a clean state before being used by providing the second protection film 50, and when the elastic dressing 1 needs to be attached to the wound surface 9, the second protection film 50 is peeled off from the surface, so that the air permeability of the isolation layer 30 is not affected.

In some examples, the first protective film 40 and/or the second protective film 50 may be a release paper. This enables effective protection.

In some examples, the spacer layer 30, the carrier layer 20, and the superhydrophobic structure 10 can be sheet-like. In this case, it can be facilitated that the elastic dressing 1 covers the target surface.

In some examples, the elastic dressing 1 may be in the form of a long roll. The elastic dressing 1 may be cut to a desired size (e.g. a shape that can cover the wound bed 9) for use.

In some examples, the elastic dressing 1 may be attached to the wound bed 9 by medical adhesive tape. Or both ends of the isolation layer 30 can be directly extended outwards, and the inner walls of both ends of the isolation layer 30 extended outwards are provided with adhesives, so that a form of a band-aid can be formed, and the elastic dressing 1 can be attached to the wound surface 9.

In view of the above, in the first aspect of the present disclosure, it is possible to provide an elastic dressing 1 that can carry a large number of repair substrates and is convenient to use, and a method for manufacturing the same.

In a second aspect of the present disclosure, a method of making a repair matrix-bearing elastic dressing 1 is provided. The method for producing the repair matrix-mounted elastic dressing 1 according to the second aspect of the present disclosure may be simply referred to as "a method for producing a dressing" or "a method for producing", and may also be referred to as a method for producing the elastic dressing 1, a method for producing a repair dressing, a method for producing a wound dressing, or the like.

Fig. 11 is a flowchart illustrating a method of manufacturing an elastic dressing 1 according to an example of the present disclosure.

The preparation method of the present disclosure comprises: preparing a resilient carrier layer 20, the carrier layer 20 having a lower surface 22 facing the target surface when applied, an upper surface 21 opposite the lower surface 22; stretching the carrier layer 20 in the transverse direction to place the carrier layer 20 in a stretched state; processing the lower surface 22 of the bearing layer 20 in a stretching state to form a plurality of accommodating parts 23 with accommodating spaces, wherein the accommodating parts 23 are grooves which are concave towards the upper surface 21 from the lower surface 22 and are provided with openings 24 positioned on the lower surface 22; filling the containment space with a healing matrix via the opening 24, the healing matrix being in the form of dry powder; the stretching of the carrier layer 20 is stopped, the carrier layer 20 is retracted to the natural state and the openings 24 are closed to retain the repair matrix in the containment space, resulting in an elastic dressing 1 (see fig. 11). The elastic dressing 1 manufactured by the manufacturing method according to the second aspect of the present disclosure is identical to the elastic dressing 1 according to the first aspect of the present disclosure, and specific description of the elastic dressing 1 can refer to the description of the elastic dressing 1 above, and will not be described herein again.

In the manufacturing method according to the second aspect of the present disclosure, the opening 24 of the housing portion 23 may be directed upward, and the repair matrix may be filled into the housing space through the opening 24. In this case, the repair matrix can be made to slide down to the bottom of the accommodating space (i.e., the end of the accommodating portion 23 facing the upper surface 21) under its own weight, thereby facilitating filling of the accommodating space with the repair matrix having a predetermined density for holding by the inner wall of the accommodating portion 23 exerting pressure thereon.

In some examples, laterally stretching the carrier layer 20 may refer to stretching the edges of the carrier layer 20 by a plurality of external pulling forces directed toward the outside of the carrier layer 20 along a direction parallel to the upper surface 21 or the lower surface 22 of the carrier layer 20. In some examples, the plurality of external pulling forces may be oppositely disposed. For example, when the number of external tensile forces is 2, the direction of the 2 external tensile forces may be set to be directed from the center of the carrier layer 20 to the outside of the carrier layer 20 and the direction of the 2 external tensile forces is opposite. This enables the carrier layer 20 to be relatively uniformly stretched, and facilitates filling of the plurality of housing portions 23 with the repair matrix.

In some examples, when the repair matrix is filled into the accommodating space through the opening 24, the filling amount of the repair matrix may be determined according to the elastic modulus of the bearing layer 20 and the size of the accommodating space of the bearing layer 20 in a natural state. Thereby, it is possible to facilitate filling of the accommodation space with an appropriate amount of the repair base material.

In some examples, when the repair matrix is filled into the receiving space via the opening 24, the volume of the filled repair matrix may be slightly larger than the volume of the receiving space of the carrier layer 20 in a natural state. Since the bearing layer 20 has elasticity, the accommodating portion 23 also has elasticity, in this case, the accommodating portion 23 can accommodate the repair substrate having a volume larger than that of the accommodating space of the bearing layer 20 in a natural state, and the inner wall of the accommodating portion 23 can generate a pressure on the repair substrate in the accommodating space toward the inside of the accommodating space, thereby being capable of facilitating the repair substrate to be more stably held in the accommodating space.

In some examples, the spill plate may be covered at the opening 24 during the process of stopping the stretching of the carrier layer 20, retracting the carrier layer 20 to a natural state, and collapsing the opening 24 to retain the repair substrate within the receiving space. During the retraction of the carrier layer 20 from the stretched state into the natural state, the receiving space is also compressed, in which case, by covering the spill plate at the opening 24, spillage of the repair substrate from the opening 24 under the pressing action of the inner wall of the receptacle 23 can be effectively prevented. In some examples, the spill plate may be removed when the carrier layer 20 is retracted to a natural state and the repair matrix in the receptacle 23 remains stable under the pressure of the inner walls of the receptacle 23.

In some examples, after the stretching of the carrier layer 20 is stopped and the carrier layer 20 is retracted to the natural state to obtain the elastic dressing 1, the elastic dressing 1 may be placed and stored with the opening 24 facing upward. This enables the repair substrate to be more stably mounted on the elastic dressing 1 during storage of the elastic dressing 1.

As described above, in the second aspect of the present disclosure, by using the manufacturing method, an elastic dressing 1 that carries a large amount of a repair substrate and is convenient to use can be obtained.

While the present disclosure has been described in detail above with reference to the drawings and the embodiments, it should be understood that the above description does not limit the present disclosure in any way. Those skilled in the art can make modifications and variations to the present disclosure as needed without departing from the true spirit and scope of the disclosure, which fall within the scope of the disclosure.

Claims

1. An elastic dressing for carrying a prosthetic substrate, the elastic dressing comprising a carrier layer having elasticity, the carrier layer having a lower surface for facing a target surface when applied, an upper surface opposite to the lower surface, and a plurality of receiving portions having receiving spaces for receiving the prosthetic substrate, the receiving portions being recesses recessed from the lower surface to the upper surface, the recesses having openings at the lower surface, the prosthetic substrate being in a dry powder form and being located in the receiving spaces, the carrier layer having a natural state and a stretched state, the openings being collapsed when the carrier layer is in the natural state to hold the prosthetic substrate in the receiving spaces, and the openings being open when the carrier layer is in the stretched state to release the prosthetic substrate in the receiving spaces.

2. The elastic dressing of claim 1, wherein a natural widest inner diameter of the containment portion is between 0.5mm and 0.8mm when the carrier layer is in the natural state and a stretched widest inner diameter of the containment portion is between 150% and 300% of the natural widest inner diameter when the carrier layer is in the stretched state.

3. The elastic dressing of claim 1, wherein said plurality of receptacles are arranged in an array, and wherein adjacent two of said openings of said plurality of receptacles are spaced apart from each other by 3mm to 5mm when said carrier layer is in said natural state.

4. The elastic dressing of claim 1, wherein said carrier layer is super hydrophilic.

5. The elastic dressing of claim 1, wherein the area of said lower surface other than said opening is referred to as a first area, said elastic dressing further comprising a superhydrophobic structure disposed at said first area.

6. The elastic dressing of claim 5, wherein the superhydrophobic structure comprises a plurality of micro-scale protrusions spaced apart on the first region, and nanoparticles disposed on surfaces of the micro-scale protrusions.

7. The elastic dressing of claim 5, wherein said elastic dressing further comprises a hydrophobic barrier layer, and said barrier layer is disposed on said upper surface.

8. The elastic dressing of claim 7, wherein the elastic moduli of the barrier layer, the carrier layer, and the superhydrophobic structure are the same or similar.

9. The elastic dressing of claim 1, further comprising a sealing film disposed on said lower surface, said sealing film completely covering said plurality of openings when said carrier layer is in said natural state.

10. A method for preparing an elastic dressing carrying a repair matrix, the method comprising: preparing a resilient carrier layer having a lower surface facing a target surface when applied, and an upper surface opposite the lower surface; transversely stretching the bearing layer to enable the bearing layer to be in a stretching state; processing the lower surface of the bearing layer in the stretching state to form a plurality of accommodating parts with accommodating spaces, wherein the accommodating parts are grooves which are recessed from the lower surface to the upper surface and are provided with openings positioned on the lower surface; filling the repair matrix into the accommodating space through the opening, wherein the repair matrix is in a dry powder state; stopping the stretching of the carrier layer, retracting the carrier layer to a natural state and collapsing the openings to retain the repair matrix within the containment space, resulting in the elastic dressing.