CN115677429A - Liquid formulations containing urease inhibitors - Google Patents
Liquid formulations containing urease inhibitors Download PDFInfo
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- CN115677429A CN115677429A CN202211178344.2A CN202211178344A CN115677429A CN 115677429 A CN115677429 A CN 115677429A CN 202211178344 A CN202211178344 A CN 202211178344A CN 115677429 A CN115677429 A CN 115677429A
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- urease inhibitor
- ethylene glycol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
- Y02P60/21—Dinitrogen oxide [N2O], e.g. using aquaponics, hydroponics or efficiency measures
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Abstract
The invention discloses a liquid preparation containing urease inhibitor, which comprises 1 to 35 mass percent of urease inhibitor and a mixed solvent, wherein the mixed solvent consists of DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol. The solvent system used by the liquid preparation is DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol, and has good solubility on urease inhibitors. The urease inhibitor can be stably stored in a solvent system for a long time. The liquid preparation of the invention has simple components and convenient preparation.
Description
Technical Field
The present invention relates to a liquid formulation containing a urease inhibitor.
Background
After the nitrogen fertilizer enters the soil, the nitrogen fertilizer is easily and rapidly degraded into nitrogen-containing substances by urease in the soil, and the substances are more easily lost through evaporation, leaching and runoff than urea per se.
The urease inhibitor is a general term of substances capable of inhibiting the activity of urease in soil, and can be used for slowing down the hydrolysis of a nitrogen fertilizer and increasing the utilization rate of the nitrogen fertilizer. N- (N-butyl) thiophosphoric triamide (NBPT) belongs to ammonium phosphate compounds, is the most mature representative of the chemicals, is one of the most effective compounds for improving the utilization rate of nitrogen fertilizers, and is widely applied abroad at present.
Industrial grade NBPT is a white powder that readily agglomerates, rapidly decomposes in the presence of water, acids and high temperatures, and is difficult to bind to fertilizer granules when used directly, compromising the effectiveness of the inhibitor. The current improved mode is to prepare the NBPT into a liquid preparation form, and evenly coat the NBPT on the surface of the nitrogen fertilizer by a granulation or infiltration mode.
As for the liquid formulation of urease inhibitor, the solvents of the liquid formulation of urease inhibitor disclosed in the prior art are dimethylsulfoxide, dioxolane compounds, glycols and derivatives, alkoxyalcohols, ether alcohols, amine alcohols, polar aprotic solvents, amine solvents, heterocyclic alcohol solvents, alkyl lactate, ethyl levulinate, and the like.
For example, CN104736500A discloses a liquid preparation containing urease inhibitor and arylalkyl alcohol, including urease inhibitor and arylalkyl alcohol, and also including glycol or glycol derivative.
Disclosure of Invention
The invention aims to provide a low-toxicity and stable liquid preparation.
The technical scheme for realizing the aim of the invention is that the liquid preparation containing the urease inhibitor comprises the urease inhibitor and a mixed solvent, wherein the mass percentage of the urease inhibitor is 1-35%, and the mixed solvent consists of DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol.
In the liquid preparation, the mass percent of DMF is 25-70%, the mass percent of ethylene glycol monoethyl ether is 5-30%, the mass percent of diethylene glycol is 5-15%, and the mass percent of ethylene glycol is 5-10%.
The urease inhibitor is phosphoric triamide or thiophosphoryl triamide derivative.
Further, the urease inhibitor is N- (N-butyl) thiophosphoryl triamide.
Preferably, the mass percentage of the urease inhibitor is 15 to 35 percent.
The invention has the positive effects that:
1. the solvent system used by the liquid preparation is DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol, and has good solubility on urease inhibitor.
2. The urease inhibitor in the liquid preparation of the present invention can be stably preserved in a solvent system for a long period of time.
3. The liquid preparation of the invention has simple components and convenient preparation.
Detailed Description
(example 1)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 15% of N- (N-butyl) thiophosphoric triamide, 70% of DMF, 5% of ethylene glycol monoethyl ether, 5% of diethylene glycol and 5% of ethylene glycol.
The N- (N-butyl) thiophosphoric triamide in the liquid preparation can be replaced by other urease inhibitors, such as other phosphoric triamide or thiophosphoric triamide derivatives, so as to obtain the corresponding liquid preparation containing the urease inhibitors.
The preparation method of the liquid preparation containing the urease inhibitor comprises the following steps: adding DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol which are used as solvents into a reaction kettle, weighing a certain amount of NBPT into the reaction kettle under the stirring state, and stirring until the NBPT is completely dissolved to obtain the liquid preparation.
When in use, the liquid preparation is mixed with the solid nitrogen fertilizer, and the NBPT is uniformly coated on the surface of the nitrogen fertilizer by the liquid preparation in a granulation or infiltration mode.
(example 2)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 25% of N- (N-butyl) thiophosphoric triamide, 50% of DMF, 15% of ethylene glycol monoethyl ether, 5% of diethylene glycol and 5% of ethylene glycol.
(example 3)
The liquid preparation containing urease inhibitor of the present example comprises the following components by weight: 25% of N- (N-butyl) thiophosphoric triamide, 40% of DMF (dimethyl formamide), 10% of ethylene glycol monoethyl ether, 15% of diethylene glycol and 10% of ethylene glycol.
(example 4)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 35% of N- (N-butyl) thiophosphoric triamide, 45% of DMF, 10% of ethylene glycol monoethyl ether, 5% of diethylene glycol and 5% of ethylene glycol.
(example 5)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 35% of N- (N-butyl) thiophosphoric triamide, 45% of DMF, 5% of ethylene glycol monoethyl ether, 10% of diethylene glycol and 5% of ethylene glycol.
(example 6)
The liquid preparation containing urease inhibitor of the present example comprises the following components by weight: 25% of N- (N-butyl) thiophosphoric triamide, 45% of DMF, 10% of ethylene glycol monoethyl ether, 10% of diethylene glycol and 10% of ethylene glycol.
(example 7)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 35% of N- (N-butyl) thiophosphoric triamide, 40% of DMF, 15% of ethylene glycol monoethyl ether, 5% of diethylene glycol and 5% of ethylene glycol.
(example 8)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 30% of N- (N-butyl) thiophosphoric triamide, 25% of DMF, 30% of ethylene glycol monoethyl ether, 10% of diethylene glycol and 5% of ethylene glycol.
(example 9)
The liquid preparation containing urease inhibitor of this example comprises the following components in weight percent: 25% of N- (N-butyl) thiophosphoric triamide, 30% of DMF, 30% of ethylene glycol monoethyl ether, 10% of diethylene glycol and 10% of ethylene glycol.
Examples 2 to 9 reference example 1 for the preparation and method of use.
(Experimental example 1)
Test group: liquid formulations of example 1 to example 9.
The test method comprises the following steps: the liquid formulations of examples 1 to 9 were hermetically stored in glass bottles at room temperature of 20 to 25 ℃ respectively, and the mass percentage of NBPT in the liquid formulations was tested on days 15, 30, 60, and 90 respectively.
The results are as follows:
initial concentration 15 days, 30 days, 60 days, 90 days
Example 1% 14.99% 14.98% 14.95% 14.90%
Example 2 25% 24.98% 24.95% 24.93% 24.89%
Example 3 25% 24.98% 24.95% 24.93% 24.89%
Example 4% 35.96% 34.92% 34.90% 34.86%
Example 5% 34.96% 34.94% 34.91% 34.88%
Example 6% 24.99% 24.96% 24.93% 24.90%
Example 7% 34.97% 34.94% 34.91% 34.88%
Example 8% 29.98% 29.95% 29.91% 29.89%
Example 9% 24.97% 24.95% 24.89% 24.85%
As can be seen from the above results, the NBPT content was hardly decreased, indicating that the urease inhibitor can be stably stored for a long period of time in the mixed solvent.
(Experimental example 2)
Test group: liquid formulations of example 1 to example 9.
The test method comprises the following steps: the liquid formulations of examples 1 to 9 were left at 0 ℃, and after 14 days, the appearance of the composition was observed and the concentration of NBPT in the liquid was detected:
whether initial concentration crystallized after 14 days
Example 1% no 14.99%
Example 2 No. 25.97%
Example 3% no 24.98%
Example 4 No 35.34.97%
Example 5% no 34.98%
Example 6% No 24.98%
Example 7% no 34.98%
Example 8% No. 30.98%
Example 9% No 24.99%
From the above results, it can be seen that the liquid formulation of the present invention is stable at low temperatures.
(Experimental example 3)
Test group: liquid formulations of example 1 to example 9.
The test method comprises the following steps: the liquid formulations of examples 1 to 9 were left at 40 ℃ for 5 days, 10 days, 15 days to adjust the concentration of NBPT in the liquid:
initial concentration 5 days (%) 10 days (%) 15 days (%)
Example 1% 15.96% 14.95% 14.92%
Example 2 25% 24.98% 24.96% 24.93%
Example 3 25% 24.98% 24.95% 24.94%
Example 4% 35.96% 34.93% 34.91%
Example 5% 34.96% 34.94% 34.91%
Example 6% 24.98% 24.96% 24.95%
Example 7% 34.97% 34.94% 34.91%
Example 8% 29.98% 29.95% 29.90%
Example 9% 24.97% 24.95% 24.91%
As can be seen from the above results, the liquid formulation of the present invention is stable at high temperatures.
Claims (5)
1. A liquid formulation comprising a urease inhibitor characterized by: the urease inhibitor comprises 1 to 35 mass percent of urease inhibitor and a mixed solvent, wherein the mixed solvent consists of DMF, ethylene glycol monoethyl ether, diethylene glycol and ethylene glycol.
2. The liquid urease inhibitor-containing formulation according to claim 1, wherein: in the liquid preparation, the mass percent of DMF is 25-70%, the mass percent of ethylene glycol monoethyl ether is 5-30%, the mass percent of diethylene glycol is 5-15%, and the mass percent of ethylene glycol is 5-10%.
3. The liquid urease inhibitor-containing formulation according to claim 1, wherein: the urease inhibitor is phosphoric triamide or thiophosphoryl triamide derivative.
4. The liquid urease inhibitor-containing formulation according to claim 2, wherein: the urease inhibitor is N- (N-butyl) thiophosphoryl triamide.
5. The liquid urease inhibitor-containing formulation according to claim 1, wherein: the mass percentage content of the urease inhibitor is 15 to 35 percent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211178344.2A CN115677429A (en) | 2022-09-27 | 2022-09-27 | Liquid formulations containing urease inhibitors |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211178344.2A CN115677429A (en) | 2022-09-27 | 2022-09-27 | Liquid formulations containing urease inhibitors |
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| CN115677429A true CN115677429A (en) | 2023-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202211178344.2A Pending CN115677429A (en) | 2022-09-27 | 2022-09-27 | Liquid formulations containing urease inhibitors |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104640826A (en) * | 2012-08-15 | 2015-05-20 | 科氏农艺服务有限责任公司 | Improved liquid compositions containing urease inhibitors and glycol alkyl ethers and methods of making and using thereof |
| CN105001024A (en) * | 2015-07-23 | 2015-10-28 | 浙江奥复托化工有限公司 | Preparation with nitration inhibition and urease inhibition functions and preparing method thereof |
| CN107787183A (en) * | 2015-04-20 | 2018-03-09 | 三井化学Agro株式会社 | Fertilizer and agrochemical formulation |
| WO2021124223A1 (en) * | 2019-12-20 | 2021-06-24 | Koch Agronomic Services, Llc | Low temperature stable aqueous formulations of n-(n-butyl) thiophosphoric triamide |
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2022
- 2022-09-27 CN CN202211178344.2A patent/CN115677429A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104640826A (en) * | 2012-08-15 | 2015-05-20 | 科氏农艺服务有限责任公司 | Improved liquid compositions containing urease inhibitors and glycol alkyl ethers and methods of making and using thereof |
| CN107787183A (en) * | 2015-04-20 | 2018-03-09 | 三井化学Agro株式会社 | Fertilizer and agrochemical formulation |
| CN105001024A (en) * | 2015-07-23 | 2015-10-28 | 浙江奥复托化工有限公司 | Preparation with nitration inhibition and urease inhibition functions and preparing method thereof |
| WO2021124223A1 (en) * | 2019-12-20 | 2021-06-24 | Koch Agronomic Services, Llc | Low temperature stable aqueous formulations of n-(n-butyl) thiophosphoric triamide |
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