CN117229108A - Liquid preparation containing urease inhibitor and application thereof - Google Patents
Liquid preparation containing urease inhibitor and application thereof Download PDFInfo
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- CN117229108A CN117229108A CN202211418158.1A CN202211418158A CN117229108A CN 117229108 A CN117229108 A CN 117229108A CN 202211418158 A CN202211418158 A CN 202211418158A CN 117229108 A CN117229108 A CN 117229108A
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- CN
- China
- Prior art keywords
- propanol
- urease inhibitor
- ethylene glycol
- cosolvent
- liquid preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002601 urease inhibitor Substances 0.000 title claims abstract description 31
- 229940090496 Urease inhibitor Drugs 0.000 title claims abstract description 26
- 239000007788 liquid Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 22
- 239000003337 fertilizer Substances 0.000 claims abstract description 19
- 239000006184 cosolvent Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 10
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 7
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
- -1 alkyl diethanolamine Chemical compound 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 4
- 150000002009 diols Chemical class 0.000 claims abstract description 4
- 150000004072 triols Chemical class 0.000 claims abstract description 3
- 239000012669 liquid formulation Substances 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims description 8
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 8
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 8
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 8
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 claims description 8
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims description 8
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 8
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- JOLQKTGDSGKSKJ-UHFFFAOYSA-N 1-ethoxypropan-2-ol Chemical compound CCOCC(C)O JOLQKTGDSGKSKJ-UHFFFAOYSA-N 0.000 claims description 4
- 229940054273 1-propoxy-2-propanol Drugs 0.000 claims description 4
- FENFUOGYJVOCRY-UHFFFAOYSA-N 1-propoxypropan-2-ol Chemical compound CCCOCC(C)O FENFUOGYJVOCRY-UHFFFAOYSA-N 0.000 claims description 4
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims description 4
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 4
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims description 4
- YEYKMVJDLWJFOA-UHFFFAOYSA-N 2-propoxyethanol Chemical compound CCCOCCO YEYKMVJDLWJFOA-UHFFFAOYSA-N 0.000 claims description 4
- XHMWPVBQGARKQM-UHFFFAOYSA-N 3-ethoxy-1-propanol Chemical compound CCOCCCO XHMWPVBQGARKQM-UHFFFAOYSA-N 0.000 claims description 4
- JDFDHBSESGTDAL-UHFFFAOYSA-N 3-methoxypropan-1-ol Chemical compound COCCCO JDFDHBSESGTDAL-UHFFFAOYSA-N 0.000 claims description 4
- LDMRLRNXHLPZJN-UHFFFAOYSA-N 3-propoxypropan-1-ol Chemical compound CCCOCCCO LDMRLRNXHLPZJN-UHFFFAOYSA-N 0.000 claims description 4
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims description 4
- 229960004063 propylene glycol Drugs 0.000 claims description 4
- HHRGNKUNRVABBN-UHFFFAOYSA-N 2-[2-hydroxyethyl(propan-2-yl)amino]ethanol Chemical compound OCCN(C(C)C)CCO HHRGNKUNRVABBN-UHFFFAOYSA-N 0.000 claims description 2
- OZICRFXCUVKDRG-UHFFFAOYSA-N 2-[2-hydroxyethyl(propyl)amino]ethanol Chemical compound CCCN(CCO)CCO OZICRFXCUVKDRG-UHFFFAOYSA-N 0.000 claims description 2
- GVNHOISKXMSMPX-UHFFFAOYSA-N 2-[butyl(2-hydroxyethyl)amino]ethanol Chemical compound CCCCN(CCO)CCO GVNHOISKXMSMPX-UHFFFAOYSA-N 0.000 claims description 2
- QRUOTIJTSNETKW-UHFFFAOYSA-N 4-ethoxybutan-1-ol Chemical compound CCOCCCCO QRUOTIJTSNETKW-UHFFFAOYSA-N 0.000 claims description 2
- KOVAQMSVARJMPH-UHFFFAOYSA-N 4-methoxybutan-1-ol Chemical compound COCCCCO KOVAQMSVARJMPH-UHFFFAOYSA-N 0.000 claims description 2
- VVOBKXXECUQKBZ-UHFFFAOYSA-N 4-propoxybutan-1-ol Chemical compound CCCOCCCCO VVOBKXXECUQKBZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 2
- 150000003997 cyclic ketones Chemical class 0.000 claims description 2
- CGZZMOTZOONQIA-UHFFFAOYSA-N cycloheptanone Chemical compound O=C1CCCCCC1 CGZZMOTZOONQIA-UHFFFAOYSA-N 0.000 claims description 2
- CRVGTESFCCXCTH-UHFFFAOYSA-N methyl diethanolamine Chemical compound OCCN(C)CCO CRVGTESFCCXCTH-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Oxohexane Chemical compound CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 claims 1
- FFWSICBKRCICMR-UHFFFAOYSA-N 5-methyl-2-hexanone Chemical compound CC(C)CCC(C)=O FFWSICBKRCICMR-UHFFFAOYSA-N 0.000 claims 1
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 claims 1
- 230000010100 anticoagulation Effects 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 150000002576 ketones Chemical class 0.000 abstract description 2
- HEPPIYNOUFWEPP-UHFFFAOYSA-N n-diaminophosphinothioylbutan-1-amine Chemical compound CCCCNP(N)(N)=S HEPPIYNOUFWEPP-UHFFFAOYSA-N 0.000 description 18
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 11
- 239000004202 carbamide Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 11
- 239000007787 solid Substances 0.000 description 9
- 238000003860 storage Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 239000013543 active substance Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000005456 alcohol based solvent Substances 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 150000004862 dioxolanes Chemical class 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- 239000000618 nitrogen fertilizer Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Fertilizers (AREA)
Abstract
The present invention relates to a fertilizer additive, and in particular to a liquid preparation containing a urease inhibitor. The liquid preparation comprises the following components in parts by weight: urease inhibitors: 16-36, solvent: 41-150, cosolvent: 3-14, regulator: 0.6-3; wherein the urease inhibitor is N-N-butyl thiophosphoric triamide; the solvent is one or more than one of ketones with 3-7 carbon atoms; the cosolvent is one or a mixture of more than one of diol or triol derivatives; the regulator is one or more of triethanolamine or diethanolamine or alkyl diethanolamine with alkyl of 1-4 carbon atoms. The liquid preparation containing urease inhibitor has excellent solubility and anticoagulation performance at normal temperature and low temperature and may be maintained stably at both normal temperature and high temperature. When applied to fertilizer, the fertilizer did not dissolve and did not agglomerate either.
Description
Technical Field
The present invention relates to a fertilizer additive, and in particular to a liquid preparation containing a urease inhibitor.
Background
Urease in the soil can catalyze urea hydrolysis, released ammonia is relatively easy to volatilize, the urea loss of the part is up to more than 60%, and the urease is also a main cause of urea nitrogen fertilizer loss. To delay the hydrolysis process, urease inhibitors have been widely used in urea-based nitrogen fertilizers, and have been shown to slow down the urea hydrolysis rate and effectively increase the crop nitrogen uptake into the soil. N-butyl thiophosphoric triamide (NBPT) is the most typical and widely applied compound of the inhibitor, is widely applied in the field of foreign fertilizers, and achieves excellent weight-losing and emission-reducing effects.
However, since NBPT is a white fine powdery solid, a substance sensitive to heat and water cannot be used in its solid form, and when it is used at a low concentration, it is difficult to uniformly distribute on urea blocks (i.e., large particles) and in soil. In order to distribute the NBPT evenly over the urea, it should be dispersed in an ideal solvent system that enables the NBPT to be evenly distributed over the particulate urea (e.g. urea blocks) and in the urea-containing liquid fertilizer prior to spraying the NBPT onto the urea.
Therefore, the type of solvent is particularly critical for liquid formulations of NBPT, and the choice of solvent is generally required to meet the following properties and requirements: the aqueous emulsion has the advantages of (1) good dissolving capacity for active ingredients of the urease inhibitor, (2) stable chemical property, no chemical reaction with the active ingredients of the inhibitor or other components, (3) safety, no toxicity or low toxicity, good environmental compatibility, safe storage, use and transportation, and the like, (4) moderate or low volatility, meets VOC control indexes, (5) no phytotoxicity to plants, safety to soil, water, atmosphere and the like, easy degradation, no residual pollution or metabolism into other toxic and harmful products, and (6) moderate condensation point, good fluidity at normal temperature and even at proper low temperature, and difficult solidification. The solvents of the liquid formulations of urease inhibitors disclosed in the prior art are mainly concentrated on dimethyl sulfoxide, N-methyl (alkyl) pyrazolone, N-dimethyl methyl (ethyl) amide, dioxolane compounds, diols and derivatives, ether alcohols, amine solvents, heterocyclic alcohol solvents, alkyl lactate and the like. Dimethyl sulfoxide, heterocyclic alcohol solvents are generally costly, however, N-dimethylformamide has potential biotoxicity, dioxolane compounds and amine solvents are susceptible to deterioration, and thus new solvent systems need to be studied.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a liquid preparation containing a urease inhibitor and application thereof.
The liquid preparation comprises the following components in parts by weight:
urease inhibitors: 16-36,
solvent: 41-150,
cosolvent: 3-14,
and (3) a regulator: 0.6-3,
wherein the urease inhibitor is N-N-butyl thiophosphoric triamide;
the solvent is one or more than one of chain or cyclic ketones with 3-7 carbon atoms;
the cosolvent is one or a mixture of more than one of diol or triol derivatives;
the regulator is one or more of triethanolamine or diethanolamine or alkyl diethanolamine with alkyl of 1-4 carbon atoms.
Preferably, the weight percentage of the urease inhibitor is 9% -40%.
Preferably, the solvent is one or more of cyclohexanone, cyclopentanone, cycloheptanone, butanone, acetone, 2-pentanone, 3-pentanone, ethyl 3-butanoate, methyl 3-butanoate, propyl 3-butanoate, isopropyl 3-butanoate, diacetone alcohol.
More preferably, the solvent is one or more of cyclohexanone, cyclopentanone, butanone, acetone, 3-butanone ethyl ester, diacetone alcohol.
Preferably, the cosolvent is one or more of ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, 1, 2-propylene glycol, 1, 3-propylene glycol, 1-methoxy-2-propanol, 1-ethoxy-2-propanol, 1-propoxy-2-propanol, 1-methoxy-3-propanol, 1-ethoxy-3-propanol, 1-propoxy-3-propanol, 1, 4-butanediol, 1-methoxy-4-butanol, 1-ethoxy-4-butanol, 1-propoxy-4-butanol, 1, 3-butanediol, 2, 3-butanediol, glycerol.
More preferably, the cosolvent is one or more of ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, 1, 2-propylene glycol, 1, 3-propylene glycol, 1-methoxy-2-propanol, 1-ethoxy-2-propanol, 1-propoxy-2-propanol, 1-methoxy-3-propanol, 1-ethoxy-3-propanol, 1-propoxy-3-propanol, 1, 4-butanediol, glycerol.
Preferably, the cosolvent is one or more of triethanolamine, diethanolamine, methyldiethanolamine, n-propyldiethanolamine, isopropyl diethanolamine and n-butyldiethanolamine.
More preferably, the regulator is triethanolamine or diethanolamine.
The use of any of the above-described liquid formulations comprising a urease inhibitor in a fertiliser.
The liquid preparation containing the urease inhibitor has the following beneficial effects:
the main solvent, the cosolvent and the regulator are preferable to form a synergistic effect (because the urease inhibitor is a large polar substance, the active substance can be conveniently dissolved by adopting a ketone solvent with large polarity, meanwhile, the cosolvent with hydroxyl can not only increase the solubility by the action of hydrogen bonds among molecules, but also improve the flow performance of a system at different temperatures, aiming at the physicochemical properties of the urease inhibitor, the stability of the active substance in the system can be effectively improved by selectively adding the regulator, the compatibility of the active substance at the application end of the fertilizer is improved, and the prepared liquid preparation containing the urease inhibitor has good solubility and anticoagulation performance at normal temperature and low temperature and can stably exist at normal temperature and high temperature. When applied to fertilizer, the fertilizer did not dissolve and did not agglomerate either.
Detailed Description
The following detailed description is of the invention further illustrating the invention, but the following detailed description is merely illustrative of the invention and is not meant to limit the scope of the invention, as all equivalents of the invention are within the scope of the invention.
1. Preparing liquid preparation
N-N-butyl thiophosphoric triamide, solvent, cosolvent and regulator are added into a reaction kettle, and liquid solutions of the examples and the comparative examples are obtained after uniform mixing, and the liquid formulations are shown in the following table.
2. Clarity test at ambient temperature
The prepared liquid formulations of examples 1-0 to 1-21 and comparative examples 2-1 to 2-6 were stored at 25℃for 1 week, 2 weeks, 4 weeks, 2 months and 3 months under sealed conditions, and the properties of the samples were visually examined.
The observation results show that the liquid formulas 1-0 to 1-21 are all clear solutions in different storage periods, and no solid crystals or solids are separated out. It can be seen that NBPT has good solubility properties in this solvent system.
The observations showed that liquid formulations 2-1, 2-2, 2-4, 2-5 were clear solutions with no solid crystals or solid precipitation at different storage periods, with the 2-3, 2-6 colors changing from initially colorless transparent to brownish black. It can be seen that the 2-3, 2-6 system is not suitable as a formulation choice for NBPT.
3. Clarity test at low temperature
The prepared liquid formulations of examples 1-0 to 1-21 and comparative examples 2-1 to 2-6 were stored under sealed conditions at 0℃for 1 week, and the properties of the samples were visually examined.
The observations show that liquid formulation examples 1-0 to 1-21 are clear solutions at different storage periods, and no solid crystals or solids are precipitated. It can be seen that NBPT has good solubility and anticoagulation performance in this solvent system.
The observations showed that the liquid formulations 2-1, 2-2, 2-4, 2-5 had solids precipitated. It can be seen that the 2-1, 2-2, 2-4, 2-5 system is not suitable as a formulation choice for NBPT.
4. Loss test at ambient temperature
The prepared selected liquid formulation examples and comparative examples were stored at 25 degrees for 15, 30, 60 and 90 days with sealed storage, and the mass percent of NBPT in each liquid composition was measured by HPLC.
From the above results, it was found that the NBPT content was reduced at normal temperature in the examples except for individual detection errors, but the loss rate was less than 2%, indicating that NBPT could be stably stored for a long period of time in the preparation system.
The formulation of comparative example 2-1 exhibited similar results to the examples, with comparative example 2-2 showing significant degradation at ambient temperature, and comparative example 2-3 changed color from initially colorless transparent to brown-black.
5. Accelerated loss test at high temperature
The prepared selected liquid formulation examples and comparative examples were stored at 45 ℃ for 7, 15, 30 and 60 days with sealed storage, and the mass percent of NBPT in each liquid composition was measured by HPLC.
From the above results, it was found that the NBPT content was reduced at a high temperature of 45℃in the examples, but the loss rate was less than 5%, indicating that the NBPT was stably present at a high temperature in the examples.
The formulation of comparative example 2-1 exhibited similar results to the examples, with comparative example 2-2 rapidly degrading at a high temperature of 45℃and with comparative example 2-3 changing color from initially colorless transparent to deep black.
6. Fertilizer application of liquid preparation
| Fertilizer | Recipe numbering | kg/ton NBPT |
| Urea | 1-21 | 4 |
| Compound fertilizer (18-18-18) | 1-21 | 3.2 |
| Compound fertilizer (15-15-15) | 1-20 | 2.7 |
| Nitro-compound fertilizer | 1-21 | 3.0 |
In all cases, the liquid formulation was applied uniformly to the fertilizer. During coating, drying and storage, there was no partial dissolution of the fertilizer and no caking.
Claims (9)
1. A liquid formulation comprising a urease inhibitor, the liquid formulation comprising the following components in parts by weight:
urease inhibitors: 16-36,
solvent: 41-150,
cosolvent: 3-14,
and (3) a regulator: 0.6-3;
wherein the urease inhibitor is N-N-butyl thiophosphoric triamide;
the solvent is one or more than one of chain or cyclic ketones with 3-7 carbon atoms;
the cosolvent is one or a mixture of more than one of diol or triol derivatives;
the regulator is one or more of triethanolamine or diethanolamine or alkyl diethanolamine with alkyl of 1-4 carbon atoms.
2. The liquid formulation containing a urease inhibitor according to claim 1, wherein the weight percentage of the urease inhibitor is 9% to 40%.
3. The liquid preparation containing a urease inhibitor according to claim 1, wherein the solvent is one or more of cyclohexanone, cyclopentanone, cycloheptanone, butanone, acetone, 2-pentanone, 3-pentanone, ethyl 3-butanone acid ester, methyl 3-butanone acid ester, propyl 3-butanone acid ester, isopropyl 3-butanone acid ester, diacetone alcohol.
4. The liquid preparation containing a urease inhibitor according to claim 1, wherein the solvent is one or a mixture of more than one of cyclohexanone, cyclopentanone, butanone, acetone, 3-butanone ethyl ester, diacetone alcohol.
5. The liquid preparation containing a urease inhibitor according to claim 1, wherein the cosolvent is one or more of ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, 1, 2-propylene glycol, 1, 3-propylene glycol, 1-methoxy-2-propanol, 1-ethoxy-2-propanol, 1-propoxy-2-propanol, 1-methoxy-3-propanol, 1-ethoxy-3-propanol, 1-propoxy-3-propanol, 1, 4-butanediol, 1-methoxy-4-butanol, 1-ethoxy-4-butanol, 1-propoxy-4-butanol, 1, 3-butanediol, 2, 3-butanediol, glycerol.
6. The liquid formulation containing a urease inhibitor according to claim 1, wherein the cosolvent is one or more of ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, 1, 2-propylene glycol, 1, 3-propylene glycol, 1-methoxy-2-propanol, 1-ethoxy-2-propanol, 1-propoxy-2-propanol, 1-methoxy-3-propanol, 1-ethoxy-3-propanol, 1-propoxy-3-propanol, 1, 4-butanediol, glycerol.
7. The liquid preparation containing a urease inhibitor according to claim 1, wherein the cosolvent is one or more of triethanolamine, diethanolamine, methyldiethanolamine, n-propyldiethanolamine, isopropyldiethanolamine, n-butyldiethanolamine.
8. The liquid formulation containing a urease inhibitor according to claim 1, wherein the regulator is triethanolamine, diethanolamine.
9. Use of a liquid formulation comprising a urease inhibitor according to any one of claims 1 to 8 in a fertiliser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211418158.1A CN117229108A (en) | 2022-11-14 | 2022-11-14 | Liquid preparation containing urease inhibitor and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211418158.1A CN117229108A (en) | 2022-11-14 | 2022-11-14 | Liquid preparation containing urease inhibitor and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117229108A true CN117229108A (en) | 2023-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211418158.1A Pending CN117229108A (en) | 2022-11-14 | 2022-11-14 | Liquid preparation containing urease inhibitor and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117229108A (en) |
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2022
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