CN115670549A - Surgical suture with improved properties - Google Patents
Surgical suture with improved properties Download PDFInfo
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- CN115670549A CN115670549A CN202111393092.0A CN202111393092A CN115670549A CN 115670549 A CN115670549 A CN 115670549A CN 202111393092 A CN202111393092 A CN 202111393092A CN 115670549 A CN115670549 A CN 115670549A
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- suture
- surgical suture
- barbs
- molded
- modifications
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- 238000012986 modification Methods 0.000 claims abstract description 44
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- 239000000463 material Substances 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
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- 108010035532 Collagen Proteins 0.000 claims description 3
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
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- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
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- 229960005188 collagen Drugs 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
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- 238000000465 moulding Methods 0.000 description 14
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
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- 238000000034 method Methods 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
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- 235000019322 gelatine Nutrition 0.000 description 1
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- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
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- 239000004626 polylactic acid Substances 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Abstract
The present application provides a surgical suture having improved properties, comprising a plurality of suture units, wherein each suture unit has at least two pairs of molded barbs, wherein the two molded barbs of each pair extend in opposite directions from each other, and a plurality of cut modifications between the two pairs of molded barbs; and the cutting modification and another adjacent cutting modification form an included angle delta relative to the seam line axis, wherein delta is between 0 and 180 degrees.
Description
Technical Field
The present application relates to a surgical suture having enhanced tension without creating protrusions on the tissue surface.
Background
The surgical suture line can increase the molding barb for strengthening the pulling force, is commonly used for the wound suture of the laparoscopic minimally invasive surgery, can draw the tissues on both sides of the wound close because of the molding barb structure of the suture line, removes the knotting requirement, and the tensile strength of the suture line can maintain the closure of the wound, and is the surgical suture line widely used at present.
However, although commercially available sutures with molded barbs improve the grip on the tissue due to suture-in-line barbs, they suffer from insufficient elasticity and, in use, problems of bulging on the tissue surface, such as the skin surface.
In response to the above problems, there is a need for surgical sutures with improved tissue surface protrusions.
Disclosure of Invention
To solve the above problems, the present application provides a surgical suture having improved properties, comprising a plurality of suture units, wherein each suture unit has at least two pairs of molding barbs and a plurality of cutting modifications, wherein the two molding barbs of each pair of molding barbs extend in opposite directions from each other, the plurality of cutting modifications being located between the 2 pairs of molding barbs; and the cutting modification and another adjacent cutting modification form an included angle delta relative to the seam line axis, wherein delta is between 0 and 180 degrees.
In one embodiment, the length of the suture unit is equal to or less than 10mm.
In one embodiment, there are at least 2 cutting modifications, such as 2-6, between the pair of molding barbs. In one particular embodiment, there are 5 cut modifications between the pair of molded barbs.
In one embodiment, the plurality of cutting modifications are arranged in a spirally symmetrical manner.
In one embodiment, the cutting modification and another adjacent cutting modification have an angle δ relative to the suture axis, δ being between 0 ° and 180 °, preferably between 15 ° and 90 °, preferably between 30 ° and 90 °.
In one embodiment, wherein the molded barb and the suture have an acute angle θ therebetween, θ is less than 90 °, preferably equal to or less than 45 °, more preferably equal to or less than 30 °.
In one embodiment, the molded barb 20 has a length of 5mm or less, preferably 1mm or less.
In one embodiment, the length of the suture unit is equal to or less than 10mm.
In one embodiment, each suture unit has at least two pairs of molded barbs and a plurality of cutting modifications arranged in a helical symmetry with the helical cutting modifications at an angle δ of 30-90 ° to the suture axis with another adjacent helical cut. Wherein there are preferably 2-6 cutting modifications between the pair of molding barbs; in a specific embodiment, there are 5 cut modifications between the two pairs of molded barbs.
Drawings
The present application is further illustrated in the following figures:
FIG. 1 is a schematic view of reference example 1 of the related art.
FIG. 2 is a schematic view of reference example 2 of the related art.
Fig. 3 is a cross-sectional view of reference example 2 of the related art.
Fig. 4 is a schematic diagram of embodiment 1 of the present application.
Fig. 5 is a sectional view of embodiment 1 of the present application.
Description of the reference numerals
10. Suture line
20. Molded barb
202. Molded barb
204. Cutting decoration
a suture unit
Acute angle of theta
Delta angle
Section tangent line of A-A
B-B' section tangent.
Detailed Description
The features of the present application, including those specifically set forth in the claims, are better understood from the description that follows, taken in conjunction with the description, examples of the principles of the application, and the accompanying drawings.
All technical and scientific terms used herein in the specification and claims are, unless otherwise defined, defined as commonly understood by one of ordinary skill in the art to which this application belongs. Where the singular forms "a," "an," "the," and their plural referents unless the context clearly dictates otherwise, may refer to more than one referent. As used herein, the terms "or", "and", unless otherwise indicated, refer to "or/and". Furthermore, the terms "comprising" and "including" are not intended to be limiting, open-ended terms. The foregoing definitions are merely illustrative of the meaning of the term definitions and should not be construed as limiting the authoring target.
The present application provides a surgical suture having improved properties comprising a plurality of suture units, wherein each suture unit has at least 2 pairs of molded barbs and a plurality of cut modifications, wherein the two molded barbs of each pair of molded barbs extend in opposite directions from each other, the plurality of cut modifications being located between the 2 pairs of molded barbs; and the cutting modification and another adjacent cutting modification form an included angle delta relative to the seam line axis, wherein delta is between 0 and 180 degrees.
Molded barbs are used to increase tension during suture processing, and cut to increase suture elasticity. However, the wire may be damaged by the cutting, the entire tension strength of the wire may be reduced by the entire suture, and if the tension strength is too weak, the wound tissue may not be maintained to be closed. The surgical suture with the molding barbs is modified by utilizing a cutting technology, so that the problem that the surface of the tissue is raised and uneven when the conventional surgical suture with the molding barbs is used is solved.
In this application, sutures are formed by heating a mold and heating and pressing the material of the surgical suture at a specific temperature during a molding process to form a barbed structure on the surface of the suture, and forming one or more barbs on the surface of the same length of suture by one or more sets of roller dies. The molded barb suture is then cut and trimmed by a cutting process over the molded suture.
In one embodiment of the present application, the seam with molded barbs is cut on-line using a cutter module and a fixture for holding the wire required for cutting, thereby reducing strength and increasing elasticity to achieve optimal overall operability and functionality of the seam.
In a specific embodiment, the cutting process described herein comprises the steps of:
the cutter cuts the suture, the cutting angle between the cutter and the thread body is between 15 and 90 degrees, the cutting position is on the suture body between the molding barbs, and the cutter rotates along the thread body to generate cutting decoration in a spiral arrangement.
The sutures of the present application may further comprise a coating that provides a desired property or function or therapeutic effect to the suture.
According to the invention, the suture body is a biocompatible material; more preferably, it may be a bioabsorbable material.
In a specific embodiment, examples of the material of the wire body include, but are not limited to: polylactic Acid (PLA), polycaprolactone (PCL), polyhydroxyalkanoate (PHA), polyglycolide (PGA), lactide (LA), polydioxanone strands (PDS), polydioxanone (PPDO), poly (Lactic-co-Glycolic Acid)) (PLGA), or combinations thereof. In a preferred embodiment, the wire is poly (p-dioxanone) (PPDO).
In a particular embodiment, the coating is selected from the group consisting of: vitamin C, vitamin E, collagen, hyaluronic acid, and combinations thereof. In a preferred embodiment, another embodiment of the coating is an antibiotic.
In a specific embodiment, the bioabsorbable material is selected from the group consisting of bioceramics, such as calcium carbonate, tricalcium phosphate, calcium sulfate, and combinations thereof. In another specific embodiment, the bioabsorbable material is selected from the group consisting of high molecular weight polymeric materials such as collagen, starch, cellulose, gelatin, chitin, hyaluronic acid, and combinations thereof.
According to the present application, since the surgical suture has the molded barb structure, the tissues are drawn close by the barb-like structure, so that it is not necessary to tie knots when it is used for wound suturing, but the tensile strength of the suture is reduced by 50% after it is placed in the body for about 4 weeks, and the number of molded barbs can be increased to enhance the tensile strength. But can cause problems with tissue surface bulging during use. In the present application, the reduction in tensile strength of the suture caused by the reduction in the number of molded barbs is improved by cutting the modification, and the problem of surface bulging of the tissue is improved by increasing the elasticity of the suture.
The surgical suture of example 1 shown in fig. 3, the barbs 20 are less than 5mm in length; in a more preferred embodiment, the length of the barbs 20 is equal to or less than 1mm.
Referring to the surgical suture of reference example 1 of the prior art shown in fig. 1, the suture 10 has a suture unit a of 10mm; each suture unit a includes 4 pairs of molded barbs 20 therein. Each pair of molding barbs was 2.5mm apart; the length of barbs 20 may be equal to or less than 1mm. The molded barb 20 has an acute angle θ with the suture 10 equal to or less than 45 °. Because the wire main body and the barbs are more and hard, the tensile strength is stronger, but the protrusions can be formed on the tissue surface when the wire main body and the barbs are used.
Referring to FIG. 2,base:Sub>A cross-sectional view of the suture 10 along A-A' is shown in FIG. 3, which provides reference example 2 of the prior art. The suture 10 has a suture unit a of 10mm; each suture unit a includes 2 pairs of molded barbs 20 therein. Each pair of molded barbs was 10mm apart; the length of barbs 20 may be equal to or less than 1mm. The molded barb 20 has an acute angle θ with the suture 10 equal to or less than 45 °. The problem of surface bulge is improved due to the reduction of barbs, but the tensile strength is reduced, and the application of clinical wound suturing is limited due to insufficient tensile force.
As shown in FIG. 4, a cross-sectional view of the suture 10 taken along B-B' of an embodiment of the suture 10 of the present application may be seen in FIG. 5. Suture units a having 2 pairs of molded barbs 202, each suture unit a having 10mm in length, have molded barbs 202 extending in directions opposite to each other, and between two suture units a adjacent to each other, barbs 20 provided to each suture unit a are arranged in the same direction, so that only one pair of barbs 20 can be observed in a cross-sectional view of B-B'.
In example 1, each suture unit a has a pair of barbs 202 (fig. 3); in this embodiment, there are a plurality of cutting modifications 204 between the 2 pairs of molded barbs 202 of each suture unit a, the number may be between 2 and 6, and 5 in this embodiment. Adjacent cut modifications 204 are spaced apart from each other by about 0.1-10mm; in a preferred embodiment, about 0.5-7.5mm apart; in a preferred embodiment, adjacent barbs 20 are spaced about 1-5mm from each other; the spacing between each cleavage modification may be the same or different.
The cutting modifications 204 form an included angle δ with each other when viewed from a cross-sectional view of B-B', and the included angle δ between any two adjacent cutting modifications 204 is the same and is arranged spirally and symmetrically. In other words, each cutting modification has an angle δ with respect to the suture axis with another adjacent cutting modification. The angle δ may be between 0o and 180o, preferably between 15o and 90o, more preferably between 30o and 90o.
Thus, as viewed in cross-section from B-B', the pairs of molded barbs 202 and the cut modifications 204 are arranged in substantially rotational symmetry, with two pairs of molded barbs 202 in suture unit a, and a cut modification 204 therebetween, with the number of cut modifications 204 being 6, and δ being 45.
In example 1, the length of the cutting modification 204 may be 0.5-1mm, preferably 0.6-0.9mm, and more preferably 0.61-0.7mm.
Comparing the properties of the surgical sutures of reference 1, reference 2, and example 1, the grasping power to human tissue and the degree of surface protrusion are compared as shown in table 1 below (scoring by a score of 1-10, with 10 being the best and 1 being the lowest):
TABLE 1
In comparison, the surgical suture provided by the application solves the problem of the protrusion of the tissue surface caused by the inelasticity of the traditional molding barb surgical suture, and simultaneously provides considerable holding power, thereby greatly improving the overall property of the surgical suture.
In the disclosure of the embodiments of the present disclosure, it is obvious to those skilled in the art that the foregoing embodiments are illustrative only and not limiting; those skilled in the art can implement the present invention by many variations and substitutions without departing from the technical features of the present application. Many variations of the present application are possible in light of the above teachings. The teachings of the various embodiments may be combined with each other without conflict. The claims presented in this specification define the scope of the application, which encompasses the methods and structures described above and equivalents thereof.
Claims (21)
1. A surgical suture having improved properties, comprising a plurality of suture units, wherein each suture unit has at least two pairs of molded barbs and a plurality of cut modifications, wherein the two molded barbs of each pair of molded barbs extend in opposite directions from one another, the plurality of cut modifications being located between the two pairs of molded barbs; and the cutting modification and another adjacent cutting modification form an included angle delta relative to the seam line axis, wherein delta is between 0 and 180 degrees.
2. The surgical suture as claimed in claim 1, wherein the suture unit has a length equal to or less than 10mm.
3. The surgical suture of claim 1, wherein there are at least 2 cut modifications between the pair of molded barbs.
4. The surgical suture of claim 3, wherein there are 2-6 cut modifications between the pair of molded barbs.
5. The surgical suture of claim 4, wherein there are 5 cut modifications between the pair of molded barbs.
6. The surgical suture of claim 3, wherein the plurality of cut modifications are in a helically symmetric arrangement.
7. The surgical suture as claimed in claim 1, wherein the included angle δ is between 15 ° -90 °.
8. The surgical suture as claimed in claim 3, wherein the included angle δ is between 30 ° -90 °.
9. The surgical suture as claimed in claim 1, wherein the molded barb has an acute angle θ with the suture, θ being less than 90 °.
10. The surgical suture as claimed in claim 9, wherein the acute angle θ is equal to or less than 45 °.
11. The surgical suture as claimed in claim 10, wherein the acute angle Θ is equal to or less than 30 °.
12. The surgical suture of claim 1, wherein the molded barb has a length equal to or less than 5mm.
13. The surgical suture of claim 12, wherein the molded barb has a length equal to or less than 1mm.
14. The surgical suture as claimed in claim 1, wherein each suture unit has at least two pairs of molded barbs and a plurality of cut modifications in a helically symmetrical arrangement with the helical cut modifications at an angle δ to the suture axis relative to the suture axis, δ being 30-90 °.
15. The surgical suture of claim 13, wherein there are 2-6 cut modifications between the pair of molded barbs.
16. The surgical suture of claim 13, wherein there are 5 cut modifications between the pair of molded barbs.
17. The surgical suture as claimed in claim 1, further comprising a coating.
18. The surgical suture as claimed in claim 1, wherein the suture body is a biocompatible material.
19. The surgical suture of claim 1, wherein the suture body is a bioabsorbable material.
20. The surgical suture of claim 17, wherein the coating is selected from the group consisting of: vitamin C, vitamin E, collagen, hyaluronic acid, and combinations thereof.
21. The surgical suture of claim 17, wherein the coating is an antibiotic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW110126879 | 2021-07-21 | ||
| TW110126879A TWI797686B (en) | 2021-07-21 | 2021-07-21 | Surgical suture with improved properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115670549A true CN115670549A (en) | 2023-02-03 |
Family
ID=85059718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111393092.0A Pending CN115670549A (en) | 2021-07-21 | 2021-11-23 | Surgical suture with improved properties |
Country Status (2)
| Country | Link |
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| CN (1) | CN115670549A (en) |
| TW (1) | TWI797686B (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6848152B2 (en) * | 2001-08-31 | 2005-02-01 | Quill Medical, Inc. | Method of forming barbs on a suture and apparatus for performing same |
| EP3721813A1 (en) * | 2019-04-12 | 2020-10-14 | B. Braun Surgical S.A. | Wound closure device |
| CN110279900A (en) * | 2019-08-01 | 2019-09-27 | 易浦润（上海）生物技术有限公司 | A kind of implantation piece and its preparation method and application |
| CN112043333A (en) * | 2020-09-28 | 2020-12-08 | 长春圣博玛生物材料有限公司 | Special-shaped medical operation line and preparation method thereof |
| TWM626216U (en) * | 2021-07-21 | 2022-05-01 | 國立臺北科技大學 | Surgical suture with improved properties |
-
2021
- 2021-07-21 TW TW110126879A patent/TWI797686B/en active
- 2021-11-23 CN CN202111393092.0A patent/CN115670549A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI797686B (en) | 2023-04-01 |
| TW202304388A (en) | 2023-02-01 |
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