CN115669663A - Insecticidal aerosol - Google Patents
Insecticidal aerosol Download PDFInfo
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- CN115669663A CN115669663A CN202210823383.7A CN202210823383A CN115669663A CN 115669663 A CN115669663 A CN 115669663A CN 202210823383 A CN202210823383 A CN 202210823383A CN 115669663 A CN115669663 A CN 115669663A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses an insecticidal aerosol, which comprises the following components in percentage by weight: 0.1 to 2 percent of component A, 0.1 to 5 percent of component B, 1 to 70 percent of component C and 23 to 98.8 percent of component D; the component A is a compound shown as a formula I; the component B is any one of permethrin, cis-cypermethrin, beta-cypermethrin, phenothrin, transfluthrin, meperfluthrin, permethrin, trans-permethrin, transfluthrin and metofluthrin, or two or more of permethrin, cis-cypermethrin, beta-cypermethrin and alpha-fluthrinThe above are mixed in any proportion to form a mixture; the component C is a solvent; the component D is a propellant; the insecticidal aerosol can control the sprayed liquid medicine amount to be 0.05ml-1ml through a special nozzle device, can quickly diffuse in space, and has the advantages of high knockdown speed and high lethality rate on pests such as mosquitoes, flies and the like;
Description
Technical Field
The invention relates to an insecticidal aerosol, which can quantitatively spray liquid medicine into a space through a quantitative spraying device, so that liquid medicine particles are dispersed more uniformly, the quick action and the lasting effect are improved, the use is convenient, the use amount of a preparation can be reduced, and the aim of effectively preventing and controlling sanitary pests is finally fulfilled.
Background
The pyrethroid compound shown in the formula I is a novel sanitary insecticide and has good basic activity for preventing and controlling sanitary pests; the pyrethroid compound shown in the formula I can be prepared according to the following reaction scheme:
wherein R is methyl or ethyl, M is sodium or potassium and R1 is hydrogen.
For example, methyl 3-formyl-2, 2-dimethylcyclopropanecarboxylate (CAS No. 62138-41-4) as a starting material is subjected to a condensation reaction with acetonitrile at 60 ℃ for 4 hours under the action of sodium ethoxide, then the pH is neutralized to 8 by addition of ethylene hydrochloric acid, ethyl acetate and water are added for liquid separation, and the oil layer is subjected to desolvation to obtain an intermediate methyl 3- (2-cyano-1-vinyl) -2, 2-dimethylcyclopropanecarboxylate.
Adding 2,3,5, 6-tetrafluorobenzyl alcohol, a catalytic amount of tetraisopropyl titanate and a toluene solvent into the obtained 3- (2-cyano-1-vinyl) -2, 2-dimethyl cyclopropane carboxylic acid methyl ester, slowly heating until a byproduct methanol is extracted by reflux, controlling in a gas phase, cooling to 0-5 ℃ after the raw materials are completely converted, dropwise adding a small amount of water, separating liquid, and desolventizing to obtain the pyrethroid compound shown in the formula I.
The pyrethroid compound with the corresponding configuration can be obtained by taking cyclopropane carboxylic acid esters with different single configurations as starting materials, for example, (1R, 3R) -3-formyl-2, 2-dimethyl cyclopropane carboxylic acid methyl ester (CAS number 27335-33-7) is taken as a starting material to be synthesized, the product of the chrysanthemic acid part 1R,3R is obtained, then distributed crystallization is carried out, double-bond CN group Z, E isomers are separated, and single 2,3,4, 5-tetrafluorobenzyl- (1R, 3R) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethyl cyclopropyl carboxylic ester or 2,3,4, 5-tetrafluorobenzyl- (1R, 3R) -3- [ (1E) -2-cyano-1-vinyl ] -2, 2-dimethyl cyclopropyl carboxylic ester can be obtained. With methyl (1R, 3S) -3-formyl-2, 2-dimethylcyclopropanecarboxylate (CAS number 55701-02-5), 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- (-2-cyano-1-vinyl) -2, 2-dimethylcyclopropylcarboxylate or 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate or 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1E) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate can be obtained.
The pyrethroid compound has the advantages of high efficiency, low toxicity, low residue and the like, has good insecticidal activity for preventing and controlling sanitary pests such as mosquitoes, flies, german cockroaches and the like, and is widely applied for many years. However, with the use of the pesticide for many years, sanitary pests such as mosquitoes, flies or German cockroaches have resistance to part of traditional pesticides, so that the control effect is reduced.
Disclosure of Invention
The invention aims to solve the technical problem of providing an insecticidal aerosol, aiming at the defects in the prior art, the pyrethroid compound shown in the formula I, in particular to 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylic ester is used as a main component; the insecticidal aerosol has very good control effect on sanitary pests such as mosquitoes, flies, bugs, fleas and the like by quantitative injection, and also provides a preparation method of the insecticidal composition and application thereof in the aspect of controlling the sanitary pests.
In order to achieve the purpose, the invention adopts the following technical scheme:
an insecticidal aerosol comprises the following components in percentage by weight: 0.1-2% of component A, 0.1-5% of component B, 1-70% of component C and 23-98.8% of component D;
the component A is a compound shown in a formula I, namely 2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylic ester;
the component B is any one of permethrin, cis-cypermethrin, beta-cypermethrin, phenothrin, transfluthrin, cyhalothrin, d-trans-chlorprophrin, transfluthrin and metofluthrin, and a mixture of two or more of the permethrin, the cis-cypermethrin, the beta-cypermethrin, the phenothrin, the transfluthrin and the metofluthrin is mixed in any proportion;
the component C is a solvent; the component D is a propellant;
in the technical scheme, the component A shown in the formula I has stereoisomerism due to asymmetric carbon atoms of the chrysanthemic acid part, and the component A is any one of all active isomers or stereoisomers thereof in the compound shown in the formula I, or a mixture of two or more of the active isomers and the stereoisomers in any proportion.
In the above technical scheme, the component A is preferably 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylic ester, i.e. a compound with the three-membered ring of the chrysanthemic acid part having a three-dimensional structure of 1R in trans.
In the technical scheme, the component B is preferably any one of permethrin, transfluthrin, right-handed trans-chloropropynthrin, transfluthrin and methoxybenzathifluthrin, or a mixture of two or more of permethrin, transfluthrin and methoxybenzathifluthrin in any proportion.
In the technical scheme, the component C is any one of water, dimethyl carbonate, propylene glycol methyl ether, glycerol butyl ether, propylene glycol butyl ether, tetrahydrofurfuryl alcohol, dimethyl adipate, dibutyl carbonate, dimethyl succinate, decanamide, 5-ethylthio-1H-tetrazole, N-dimethyldecanamide, N-diethylformamide, dimethyl glutarate, dipropylene glycol dimethyl ether, dimethyl amide, cyclohexanediol monomethyl ether, methyl tert-butyl ether, tributyl acetylcitrate, C8-18 alkane solvents and C2-8 alcohol solvents, or a mixture of two or more of the above solvents mixed in any proportion.
In the above embodiment, the C8-18 alkane solvent is preferably any one of D60 (Exxon Mobil petrochemical Co.), D80 (Exxon Mobil petrochemical Co.), D100 (Exxon Mobil petrochemical Co.), D110 (Exxon Mobil petrochemical Co.), isopar-E (Exxon Mobil petrochemical Co.), isopar-G (Exxon Mobil petrochemical Co.), isopar-H (Exxon Mobil petrochemical Co.), isopar-L (Exxon Mobil petrochemical Co.), isopar-M (Exxon Mobil petrochemical Co.), octane, nonane, squalane, undecane, dodecane, tridecane, tetradecane, pentadecane, and hexadecane, or a mixture of two or more thereof mixed in any ratio.
In the above technical scheme, the C2-8 alcohol solvent is preferably any one of ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomers, n-hexanol and its isomers, n-heptanol and its isomers, and n-octanol and its isomers, or a mixture of two or more thereof mixed in any ratio.
In the technical scheme, the component D is liquefied petroleum gas, propane and butane, dimethyl ether or compressed air.
The pesticidal aerosol of the present invention may contain a synergist (e.g., PBO), a fragrance, and an antioxidant (e.g., BHA, BHT, etc.), as required.
The invention also provides a preparation method of the insecticidal aerosol, which comprises the following steps: mixing the component A, the component B and the component C (and the synergist, the aromatic and the bactericide which are selected according to the situation) in the proportion at the temperature of 30-50 ℃, adding the mixture into a spray can provided with a quantitative spray valve (0.05 ml-1ml of the valve), and adding the component D into the spray can under the pressure to obtain the insecticidal aerosol capable of being sprayed quantitatively.
The invention also provides application of the insecticidal aerosol in the aspect of preventing and controlling sanitary pests in public places.
In the technical scheme, when the insecticidal aerosol is used for preventing and controlling sanitary pests in public places, the insecticidal aerosol is sprayed for 2 times or more in a certain space through a quantitative spray valve, the spraying times are determined according to the space size, and the average spraying time is 5m 3 Sprayed 1 time.
In the above technical solution, the public places refer to schools, residences, hotels, shopping malls, and other places.
In the technical scheme, the sanitary pests refer to mosquitoes, flies, bugs, fleas and other sanitary pests.
In the above technical solution, the sanitary insect pests further include culex pipiens pallens, culex fatigues, culex tritaeniorhynchus, aedes albopictus, aedes aegypti, anopheles sinensis, aedes molesta, aedes volvatus, housefly, city fly, chrysomyia megacephala, lucilia cuprina, lucilia glauca, summer fly, metatoilet fly, bed bug, flea, and the like.
The pesticide aerosol of the invention is used as follows: opening a valve of the quantitative spray valve, generating high-speed airflow under the pressure action of the propellant, and dispersing and atomizing the effective component liquid medicine in the aerosol tank to form fogdrops by utilizing the vaporization energy of the propellant; after the spray is sprayed into the space, the sprayed fog drops can be quickly dispersed and diffused in the space, and can not fall to the ground for 1-2 hours, and the quick action is good; the fog drops can be adhered to ceilings, wall surfaces, floors and the like, and the effect lasts well.
The inventionThe pesticide aerosol in (1) is sprayed for 2 times or more in a certain space by controlling the sprayed pesticide amount through the quantitative spray valve, and sprayed droplets can be rapidly dispersed in the space, so that compared with the conventional aerosol, the pesticide aerosol is relatively small in quantitative sprayed dose, less in sprayed solvent and safer to environment and human bodies; and the spraying times can be customized according to the space size, for example, one-time spraying can reach 5m 3 Prevention of space, 20m 3 The space can achieve prevention effect only by spraying for 1 time at each of 4 corners of the space, so that the aim of effectively helping liquid medicine to be distributed more uniformly in spaces with different sizes can be fulfilled, the conventional aerosol can enter the space after being sprayed for at least 30min and then the indoor space is ventilated, the use method of the invention does not need to be the same, and people can stay indoors after the liquid medicine is sprayed, so that the invention is safer for human health.
The insecticidal aerosol disclosed by the invention has the characteristics of knock-down block, high lethality and low toxicity, is good in quick-acting property and persistence, accords with the national policy of synergy and reduction of administration, and is more environment-friendly, lower in carbon, safer and more convenient in use compared with the conventional aerosol.
Detailed Description
The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following descriptions:
the invention will now be illustrated with reference to specific examples:
formulation example 1
An insecticidal aerosol is prepared by the following method:
formulation example 1 was prepared by mixing 0.2g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of permethrin, and D11027.8g at 35 deg.C, charging into a spray can, loading a 0.5ml metered dose spray valve, forcing 70g of propane-butane into the can, shaking thoroughly and then loading the spray can with a spray head.
Formulation example 2
An insecticidal aerosol is prepared by the following method:
formulation example 2 was prepared by mixing 0.2g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of permethrin, 10g of ethanol, 17.8g of propylene glycol monobutyl ether at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 3
An insecticidal aerosol is prepared by the following method:
formulation example 3 was prepared by mixing 0.2g of 2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropanecarboxylate, 2g of permethrin, 10g of ethanol, and 17.8g of butyl cellosolve at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting a spray head onto the spray can.
Formulation example 4
An insecticidal aerosol is prepared by the following method:
formulation example 4 was prepared by mixing 0.6g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2.4g of cis-cypermethrin, D10010g, dimethyl carbonate at 35 deg.C, charging to a spray can, fitting a 0.5ml metered spray valve, pressing 70g of propane butane into the can, shaking thoroughly, and fitting the spray can with a spray head.
Formulation example 5
An insecticidal aerosol is prepared by the following method:
formulation example 5 was prepared by mixing 1g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of beta-cypermethrin, 15g of propyleneglycol methylether, and D8012g at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 6
An insecticidal aerosol is prepared by the following method:
formulation example 6 was prepared by mixing 1g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of beta-cypermethrin, 12g of propyleneglycol monobutyl ether, and 15g of isopar-E at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly, and fitting the spray can with a spray head.
Formulation example 7
An insecticidal aerosol is prepared by the following method:
formulation example 7 was prepared by mixing 0.6g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropanecarboxylate, 2.5g of phenothrin, 8g of dibutyl adipate, 18.9g of ethanol at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 8
An insecticidal aerosol is prepared by the following method:
formulation example 8 was prepared by mixing 1.2g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropanecarboxylate, 3.8g of phenothrin, 11g of dibutyl carbonate, and 14g of ethanol at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 9
An insecticidal aerosol is prepared by the following method:
formulation example 9 was prepared by mixing 1.5g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropanecarboxylate, 2.5g of transfluthrin, 8g of dimethyl succinate, and 18g of isopropyl alcohol at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly, and fitting the spray can with a spray head.
Formulation example 10
An insecticidal aerosol is prepared by the following method:
formulation example 10 was prepared by mixing 0.4G of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2.6G of transfluthrin, 1.2G of dipropylene glycol dimethyl ether, and 15G of isopar-G at 35 deg.C, charging to a spray can, fitting a 0.5ml metered dose spray valve, pressing 70G of propane-butane into the can, shaking thoroughly, and fitting the spray can with a spray head.
Formulation example 11
An insecticidal aerosol is prepared by the following method:
formulation example 11 was prepared by mixing 0.4g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2.6g of tetrafluoroethane, 12g of methyl tert-butyl ether, and 15g of isopar-H at 35 ℃ in a spray can, filling the spray can with a 0.5ml metered dose valve, filling 70g of propane-butane into the can, shaking thoroughly and filling the spray can with a spray head.
Formulation example 12
An insecticidal aerosol is prepared by the following method:
formulation example 12 was prepared by mixing 0.4g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2.6g of tetrafluoroethane, 13.5g of tributyl acetylcitrate, and 13.5g of isopar-L at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, forcing 70g of propane-butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Formulation example 13
An insecticidal aerosol is prepared by the following method:
formulation example 13 was prepared by mixing 0.4g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylic acid ester, 1.5g of meperfluthrin, 15g of tributyl acetylcitrate, and 13.1g of isopar-M at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane-butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Formulation example 14
An insecticidal aerosol is prepared by the following method:
formulation example 14 was prepared by mixing 0.8g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylate, 1.2g of meperfluthrin, 15g of ethanol, 13g of cyclohexanediol monomethyl ether at 35 deg.C, charging to a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 15
An insecticidal aerosol is prepared by the following method:
formulation example 15 was prepared by mixing 0.8g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.4g of d-trans-propargyl chloride, 15g of ethanol, 13.8g of tributyl acetyl citrate at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane-butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Formulation example 16
An insecticidal aerosol is prepared by the following method:
formulation example 16 was prepared by mixing 1.2g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.6g of d-trans-propargyl chloride, 20g of ethanol, and 8.2g of tetrahydrofurfuryl alcohol at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, forcing 70g of propane-butane into the can, shaking thoroughly and then fitting the spray can with a spray head.
Formulation example 17
An insecticidal aerosol is prepared by the following method:
formulation example 17 was prepared by mixing 0.4g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.6g of tetrafluoromethothrin, 15g of ethanol, and 14g of D11014g at 35 ℃ into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Formulation example 18
An insecticidal aerosol is prepared by the following method:
formulation example 18 was prepared by mixing 0.6g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 0.8g of tetrafluoromethothrin, 8g of oleamide, and D6020.6g at 35 ℃ into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly, and fitting the spray can with a spray head.
Formulation example 19
An insecticidal aerosol is prepared by the following method:
formulation example 19 was prepared by mixing 0.7g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylic acid ester, 0.9g of methoprene, 8g of ethanol, and 20.4g of D8020 at 35 deg.C, charging to a spray can, fitting a 0.5ml metered dose spray valve, forcing 70g of propane butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Formulation example 20
An insecticidal aerosol is prepared by the following method:
formulation example 20 was prepared by mixing 0.5g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylate, 1.2g of bifenthrin, 15g of dibutyl adipate, and D10013.3g at 35 deg.C, charging into a spray can, fitting a 0.5ml metered dose spray valve, pressing 70g of propane butane into the can, shaking thoroughly and fitting the spray can with a spray head.
Comparative example 1
Comparative example 1 was prepared by mixing 0.2g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2g of permethrin, and D11027.8g at 35 ℃ and charging into a spray can, charging a conventional spray valve, charging 70g of propane-butane into the can, shaking sufficiently and then charging the spray can with a spray head.
Comparative example 2
Comparative example 2 was prepared by mixing 0.4g of 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, 2.6g of tetrafluoroethane, 12g of tributyl acetylcitrate, and 15g of isopar-H at 35 ℃ in a spray can, installing a conventional spray valve, pressing 70g of propane-butane into the can, shaking sufficiently and then installing a head on the spray can.
Application examples
Test reagents: formulation examples 1, 2,3,5,6, 11, 12 of the present invention and comparative examples 1 and 2;
testing insects: culex pipiens pallens, female adults who have not taken blood 3-5 days after eclosion;
the first test method comprises the following steps: at 28m 3 In a simulation room (length 3.16m, width 3.16m, height 2.8 m), 100 culex pipiens pallens are put, four corners of the simulation room are sprayed 1 time each at 2m from the ground (preparation example), the total spraying amount is 2ml, the comparative example sprays normally and weighs, the volume of the sprayed preparation is calculated according to specific gravity, the number of culex pipiens pallens knocked down is observed within one hour, and the half knock down time (KT 50) of culex pipiens pallens is calculated;
table 1 test methods-results of drug effect comparison
| Formulation number | Total dose of the preparation | Active ingredient (mg) | KT50 (minute) |
| Formulation example 1 | 2ml | 44 | 32.6 |
| Formulation example 2 | 2ml | 44 | 28.7 |
| Formulation example 3 | 2ml | 44 | 34.2 |
| Comparative example 1 | 1.6g (reduced about 2 ml) | 44 | 62.8 |
| Comparative example 1 | 3.2g (reduced by about 4 ml) | 88 | 49.7 |
| Comparative example 1 | 4.8g (reduced to about 6 ml) | 132 | 33.7 |
| Formulation example 11 | 2ml | 60 | 18.6 |
| Formulation example 12 | 2ml | 60 | 19.2 |
| Comparative example 2 | 1.6g (reduced about 2 ml) | 60 | 38.7 |
| Comparative example 2 | 4.8g(reduced to about 6 ml) | 180 | 19.5 |
As can be seen from table 1, the efficacy of the conventional aerosol, as shown in comparative examples 1 and 2, is far worse than that of the metered dose spray, and from experimental data, the efficacy of the metered dose aerosol is about 3 times that of the conventional aerosol under the same formulation condition, and the quick action is better.
And a second test method: at 28m 3 In the simulation room (length 3.16m, width 3.16m, height 2.8 m), four corners of the simulation room are sprayed 1 time each at 2m above the ground (preparation example), the total spraying amount is 2ml, the comparative example sprays normally and weighs, the volume of the sprayed preparation is calculated according to specific gravity, 100 culex pipiens pallens are put after 1 hour, the number of the knocked down culex pipiens pallens is observed in one hour, and the half knocking down time of the culex pipiens pallens is calculated (KT 50);
table 2 test methods two drug effect comparison results
As can be seen from table 2, the efficacy of the formulation example or the comparative example is reduced after the test insects are sprayed for 1 hour, but the efficacy of the comparative examples 1 and 2 is reduced remarkably, and the efficacy of the formulation example is reduced but the reduction range is small, so that the quantitatively sprayed droplets are smaller, are easier to diffuse in the air, and have a slower rate of drop, while most of the droplet particles fall onto the ground after 1 hour in the conventional aerosol, which is also the reason for the remarkable reduction of efficacy.
And it can be seen from the comparison of formulation examples 1 and 2, 11 and 12 that, also for quantitative spraying, the same effective component ratio and concentration, the medicinal effect of which is different, mainly the influence of solvent components in the formulation, propylene glycol butyl ether in formulation example 2 and tributyl acetyl citrate in formulation example 12 have certain promotion effect on the atomization performance, and the size of the sprayed droplets is determined by the spraying device and the amount of propane and butane on the one hand, and the solvent in the formulation system on the other hand.
The test method III comprises the following steps: at 28m 3 In the simulated room (length 3.16m, width 3.16m, height 2.8 m), four corners of the simulated room are sprayed 1 time respectively at 2m above the ground (preparation example), the total spraying amount is 2ml, the comparative example sprays normally and weighs, the volume of the sprayed preparation is calculated according to specific gravity, after 1 hour, an exhaust device is started, air in the simulated room is replaced for 0.5 hour, then 100 culex pipiens pallens are put in, the number of the culex pipiens pallens knocked down is observed within one hour, and the half knock-down time of the culex pipiens pallens is calculated (KT 50);
table 3 test methods three efficacy comparison results
| Formulation number | Total dose of the preparation | Active ingredient (mg) | KT50 (minute) |
| Formulation example 1 | 2ml | 44 | 158.6 |
| Formulation example 2 | 2ml | 44 | 62.7 |
| Formulation example 5 | 2ml | 60 | 55.3 |
| Formulation example 6 | 2ml | 60 | 40.6 |
After air replacement, the simulated indoor space should have no medicament, most of the medicament falls to the ground or the medicament remaining in the space is exhausted and removed, theoretically, the medicament effects of the preparation examples 1 and 2 should be almost the same, the medicament effects of the preparation examples 5 and 6 should be almost the same, but the difference is very large from the test data, and the research shows that the medicament is not present in the simulated indoor space. The addition of the propylene glycol butyl ether and the propylene glycol methyl ether in the formula can enable the sprayed fog drops to have certain viscosity, when the fog drops fill the whole space, a part of fog drops can be adhered to the wall surface and the ceiling, and the normal habit of the culex pipiens pallens is inhabited on the ground, the wall surface and the ceiling, so that the drug effect is relatively durable.
The above examples are only for illustrating the technical idea and technical features of the present invention, and the protection scope of the present invention is not limited thereby. All equivalent changes and modifications made according to the spirit of the present invention should be covered in the protection scope of the present invention.
Claims (10)
1. The insecticidal aerosol is characterized by comprising the following components in percentage by weight: 0.1 to 2 percent of component A, 0.1 to 5 percent of component B, 1 to 70 percent of component C and 23 to 98.8 percent of component D;
the component A is a compound shown in a formula I, namely 2,3,4, 5-tetrafluorobenzyl-3- [ -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropyl carboxylic acid ester;
the component B is any one of permethrin, cis-cypermethrin, beta-cypermethrin, phenothrin, transfluthrin, cyhalothrin, d-trans-chlorprophrin, transfluthrin and metofluthrin, and a mixture of two or more of the permethrin, the cis-cypermethrin, the beta-cypermethrin, the phenothrin, the transfluthrin and the metofluthrin is mixed in any proportion;
the component C is a solvent; the component D is a propellant;
2. the insecticidal aerosol as claimed in claim 1, wherein the component A is any one of, two of and a mixture of any ratio of all active isomers or stereoisomers thereof in the compound shown in the formula I.
3. The insecticidal aerosol formulation according to claim 2, wherein the component A is 2,3,4, 5-tetrafluorobenzyl- (1R, 3S) -3- [ (1Z) -2-cyano-1-vinyl ] -2, 2-dimethylcyclopropylcarboxylate, which is a compound having a three-membered ring with a 1R, trans-form structure in the chrysanthemic acid moiety.
4. The insecticidal aerosol as claimed in claim 1, wherein the component B is any one of permethrin, transfluthrin, permethrin-permethrin and permethrin-bifenthrin, and a mixture of two or more of permethrin, transfluthrin and permethrin in any proportion.
5. The insecticidal aerosol formulation according to claim 1, wherein the component C is any one of water, dimethyl carbonate, propylene glycol methyl ether, glycerol butyl ether, propylene glycol butyl ether, tetrahydrofurfuryl alcohol, dimethyl adipate, dibutyl carbonate, dimethyl succinate, decanoamide, 5-ethylthio-1H-tetrazole, N-dimethyldecanoamide, N-diethylformamide, dimethyl glutarate, dipropylene glycol dimethyl ether, dimethylamide, cyclohexanediol monomethyl ether, methyl t-butyl ether, tributyl acetylcitrate, C8-18 alkane solvents, C2-8 alcohol solvents, or a mixture of two or more thereof mixed in any ratio.
6. The insecticidal aerosol of claim 1, wherein the component D is liquefied petroleum gas, propane and butane, dimethyl ether or compressed air.
7. A process for producing an insecticidal aerosol according to any one of claims 1 to 6, comprising the steps of: mixing the component A, the component B and the component C in the proportion at the temperature of 30-50 ℃, adding the mixture into a spray can with a quantitative spray valve, and adding the component D into the spray can under the pressure action to obtain the insecticidal aerosol capable of being sprayed quantitatively.
8. Use of an insecticidal aerosol formulation according to any one of claims 1 to 6 for controlling sanitary pests in public places.
9. The use of claim 8, wherein the aerosol formulation is applied to control sanitary pests in public places by spraying 2 or more times through a metered dose spray valve in a space, the number of spraying being determined according to the size of the space, and the average is 5m 3 Sprayed 1 time.
10. The application of claim 8, wherein the public places refer to schools, residences, hotels, shopping malls, and the like; the sanitary insect pests refer to mosquito, fly, bed bug, flea and other sanitary insect pests.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101646345A (en) * | 2007-03-30 | 2010-02-10 | 住友化学株式会社 | Pesticidal aerosol composition |
| CN102349536A (en) * | 2011-08-16 | 2012-02-15 | 江苏扬农化工股份有限公司 | Long-acting insecticidal spraying agent and application thereof |
| CN102870772A (en) * | 2012-10-18 | 2013-01-16 | 江苏扬农化工股份有限公司 | Pesticide spray |
| CN103651339A (en) * | 2012-09-13 | 2014-03-26 | 住友化学株式会社 | Composition for aerosol for controlling flying-insect pest |
| CN104273120A (en) * | 2012-10-18 | 2015-01-14 | 江苏扬农化工股份有限公司 | Insecticide spray |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101646345A (en) * | 2007-03-30 | 2010-02-10 | 住友化学株式会社 | Pesticidal aerosol composition |
| CN102349536A (en) * | 2011-08-16 | 2012-02-15 | 江苏扬农化工股份有限公司 | Long-acting insecticidal spraying agent and application thereof |
| CN103651339A (en) * | 2012-09-13 | 2014-03-26 | 住友化学株式会社 | Composition for aerosol for controlling flying-insect pest |
| CN102870772A (en) * | 2012-10-18 | 2013-01-16 | 江苏扬农化工股份有限公司 | Pesticide spray |
| CN104273120A (en) * | 2012-10-18 | 2015-01-14 | 江苏扬农化工股份有限公司 | Insecticide spray |
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