CN1156587A - Non-crystal mannitol injection and preparing process thereof - Google Patents
Non-crystal mannitol injection and preparing process thereof Download PDFInfo
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- CN1156587A CN1156587A CN 96120548 CN96120548A CN1156587A CN 1156587 A CN1156587 A CN 1156587A CN 96120548 CN96120548 CN 96120548 CN 96120548 A CN96120548 A CN 96120548A CN 1156587 A CN1156587 A CN 1156587A
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- mannitol
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- sodium chloride
- water
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Abstract
A non-crystal mannitol injection contains mannitol, sodium chloride and water for injection, and features no crystallization at ordinary temp, no change in curative effect and convenience in clinic application without time delay to rescue emergency patient.
Description
The present invention relates to a kind of mannitol injection and preparation method thereof, specifically is a kind of non-crystal mannitol and preparation method thereof, and mannitol injection of the present invention does not have crystallization at normal temperatures and separates out.
Formula mannitol injection liquid is a dehydrant commonly used clinically, has characteristics such as rapid-action, that effect is remarkable, is widely used clinically.Formula mannitol injection liquid prescription of the prior art is: mannitol 200-250 gram, 1000 milliliters of waters for injection are a kind of supersaturation injection.But this injection exists certain shortcoming and defect in clinical practice, because existing formula mannitol injection liquid is a kind of supersaturated solution, often separates out crystallization under the room temperature, need to use after 80 ℃ of warm joltings, incur loss through delay rescue time for the critical patient, given clinical many inconvenience that brought.Therefore, be starved of the formula mannitol injection liquid that no crystallization is separated out under a kind of room temperature clinically.
The present invention seeks to develop a kind of non-crystal mannitol injection, this formula mannitol injection liquid does not have that crystallization is separated out and do not change its curative effect again at normal temperatures.
Another object of the present invention provides a kind of preparation method of non-crystal mannitol injection.
The said non-crystal mannitol injection of the present invention contains following component:
Mannitol 100-200 gram
Sodium chloride 10-100 gram
Water for injection adds to 1000 milliliters
Non-crystal mannitol injection component preferred content of the present invention is:
Mannitol 100-200 gram
Sodium chloride 30-50 gram
Water for injection adds to 1000 milliliters
Amount of sodium chloride the best is 30 grams in the non-crystal mannitol injection of the present invention.
The preparation technology of non-crystal mannitol injection of the present invention is as follows:
Get mannitol, sodium chloride by above-mentioned prescription, add an amount of water for injection and make its dissolving, add 2-10 gram active carbon then, stir, heated and boiled 8-12 minute, filter, add water for injection to total amount, filtered while hot.Embedding was with hot pressing 115-120 ℃, the sterilization of the condition of pressure 0.07-0.10Mpa 40 minutes.
Its structural formula of mannitol of the present invention is as follows:
Formula mannitol injection liquid of the present invention, its advantage are not occur crystallization at normal temperatures, have overcome crystallization of the prior art and have separated out phenomenon, need not to heat jolting before using.Particularly for the critical patient, can use at any time and be unlikely to incur loss through delay rescue opportunity.
Embodiment 1
Get mannitol 100 grams, sodium chloride 10 grams add an amount of water for injection and make its dissolving, add 2 gram active carbons then, stir, heated and boiled 8 minutes filters, and adds water for injection to 1000 milliliter, filtered while hot, embedding was sterilized 40 minutes with the condition of 115 ℃ of hot pressing, pressure 0.07Mpa, promptly.
Embodiment 2
Get mannitol 200 grams, sodium chloride 100 grams add an amount of water for injection and make its dissolving, add the active carbon of 10 grams then, stir, heated and boiled 12 minutes filters, and adds water for injection to 1000 milliliter, filtered while hot, embedding was sterilized 40 minutes with the condition of 120 ℃ of hot pressing, pressure 0.10Mpa.
Embodiment 3
Get mannitol 150 grams, sodium chloride 50 grams add an amount of water for injection and make its dissolving, add the active carbon of 4 grams then, stir, heated and boiled 10 minutes filters, and adds water for injection to 1000 milliliter, filtered while hot, embedding was sterilized 40 minutes with the condition of 120 ℃ of hot pressing, pressure 0.10Mpa.
Claims (5)
1, a kind of non-crystal mannitol injection is characterized in that the content of each component is:
Mannitol 100-200 gram
Sodium chloride 10-100 gram
Water for injection adds to 1000 milliliters
2,, it is characterized in that the content of each component is according to the injection of claim 1:
Mannitol 150 grams
Sodium chloride 30-50 gram
Water for injection adds to 1000 milliliters
3,, it is characterized in that amount of sodium chloride is 30 grams according to the injection of claim 2.
4, a kind of preparation technology of non-crystal mannitol injection, it is characterized in that getting mannitol 100-200 gram, sodium chloride 10-100 gram, add an amount of water for injection and make its dissolving, add 2-10 gram active carbon then, stir, heated and boiled 8-12 minute, filter, add water for injection to 1000 milliliter, filtered while hot, embedding was with hot pressing 115-120 ℃, the sterilization of the condition of pressure 0.07-0.10Mpa 40 minutes.
5, preparation technology according to claim 3 is characterized in that the described heated and boiled time is 10 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96120548 CN1156587A (en) | 1996-12-13 | 1996-12-13 | Non-crystal mannitol injection and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96120548 CN1156587A (en) | 1996-12-13 | 1996-12-13 | Non-crystal mannitol injection and preparing process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1156587A true CN1156587A (en) | 1997-08-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96120548 Pending CN1156587A (en) | 1996-12-13 | 1996-12-13 | Non-crystal mannitol injection and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1156587A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999059602A1 (en) * | 1998-05-15 | 1999-11-25 | Chaoying Zhao | Novel pharmaceutical composition for use in emergency treatment and preparation method thereof |
| CN102406603A (en) * | 2006-06-12 | 2012-04-11 | 齐鲁制药(海南)有限公司 | Stable supersaturated gemcitabine hydrochloride solution and preparation method thereof |
| CN103432066A (en) * | 2013-07-23 | 2013-12-11 | 蚌埠丰原涂山制药有限公司 | Compound mannitol injection and preparation method thereof |
| CN105147602A (en) * | 2015-10-23 | 2015-12-16 | 广西裕源药业有限公司 | Mannitol injection |
| CN105147600A (en) * | 2015-10-23 | 2015-12-16 | 广西裕源药业有限公司 | Compound mannitol injection |
| CN105287368A (en) * | 2015-10-23 | 2016-02-03 | 广西裕源药业有限公司 | Mannitol injection |
| CN106074372A (en) * | 2016-08-11 | 2016-11-09 | 安徽环球药业股份有限公司 | The preparation method of formula mannitol injection liquid |
| CN106551901A (en) * | 2017-01-02 | 2017-04-05 | 江苏恒丰强生物技术有限公司 | Animal compound formula mannitol injection liquid |
| CN116983258A (en) * | 2023-07-25 | 2023-11-03 | 河南双鹤华利药业有限公司 | Preparation process of mannitol injection not easy to crystallize |
-
1996
- 1996-12-13 CN CN 96120548 patent/CN1156587A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999059602A1 (en) * | 1998-05-15 | 1999-11-25 | Chaoying Zhao | Novel pharmaceutical composition for use in emergency treatment and preparation method thereof |
| EA003369B1 (en) * | 1998-05-15 | 2003-04-24 | Чаоын Жао | Novel pharmaceutical composition for use in emergency treatment and preparation method thereof |
| AP1185A (en) * | 1998-05-15 | 2003-07-04 | Chaoying Zhao | Novel pharmaceutical composition for the use in emergency treatment and preparation method thereof. |
| US6986905B1 (en) | 1998-05-15 | 2006-01-17 | Chaoying Zhao | Pharmaceutical compositions for treating and saving and the method for the preparation thereof |
| CN102406603A (en) * | 2006-06-12 | 2012-04-11 | 齐鲁制药(海南)有限公司 | Stable supersaturated gemcitabine hydrochloride solution and preparation method thereof |
| CN103432066A (en) * | 2013-07-23 | 2013-12-11 | 蚌埠丰原涂山制药有限公司 | Compound mannitol injection and preparation method thereof |
| CN105287368A (en) * | 2015-10-23 | 2016-02-03 | 广西裕源药业有限公司 | Mannitol injection |
| CN105147600A (en) * | 2015-10-23 | 2015-12-16 | 广西裕源药业有限公司 | Compound mannitol injection |
| CN105147602A (en) * | 2015-10-23 | 2015-12-16 | 广西裕源药业有限公司 | Mannitol injection |
| CN105287368B (en) * | 2015-10-23 | 2018-06-29 | 广西裕源药业有限公司 | A kind of formula mannitol injection liquid |
| CN105147600B (en) * | 2015-10-23 | 2018-06-29 | 广西裕源药业有限公司 | A kind of compound formula mannitol injection liquid |
| CN105147602B (en) * | 2015-10-23 | 2018-06-29 | 广西裕源药业有限公司 | Formula mannitol injection liquid |
| CN106074372A (en) * | 2016-08-11 | 2016-11-09 | 安徽环球药业股份有限公司 | The preparation method of formula mannitol injection liquid |
| CN106551901A (en) * | 2017-01-02 | 2017-04-05 | 江苏恒丰强生物技术有限公司 | Animal compound formula mannitol injection liquid |
| CN116983258A (en) * | 2023-07-25 | 2023-11-03 | 河南双鹤华利药业有限公司 | Preparation process of mannitol injection not easy to crystallize |
| CN116983258B (en) * | 2023-07-25 | 2024-03-22 | 河南双鹤华利药业有限公司 | Preparation process of mannitol injection not easy to crystallize |
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