CN115644881A - Flexible neural electrode implantation device and system - Google Patents
Flexible neural electrode implantation device and system Download PDFInfo
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- CN115644881A CN115644881A CN202211098005.3A CN202211098005A CN115644881A CN 115644881 A CN115644881 A CN 115644881A CN 202211098005 A CN202211098005 A CN 202211098005A CN 115644881 A CN115644881 A CN 115644881A
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Abstract
The invention relates to the technical field of brain-computer interfaces, in particular to a flexible nerve electrode implantation device and system. The device includes: the flexible nerve electrode, the fixing frame and the implantation auxiliary component are arranged on the fixing frame; the flexible nerve electrode comprises an electrode interface unit and at least one flexible nerve probe; the electrode interface unit is arranged on the fixed frame; the flexible nerve probe comprises an implantation tail end and an implantation front end, and the implantation tail end is connected with the electrode interface unit; the implantation auxiliary assembly comprises at least one implantation auxiliary piece, one end of the implantation auxiliary piece is correspondingly connected with the implantation front end one by one, and the implantation auxiliary piece is used for assisting the implantation of the flexible nerve probe; the implantation auxiliary part is detachably connected with the fixing frame. Through carrying out one-to-one ground with implanting auxiliary member and flexible nerve probe and preassembling together, can directly utilize when implanting to implant auxiliary member with flexible nerve probe, greatly reduced and implanted the time that consumes, improve implantation efficiency, the security of guarantee flexible nerve probe implantation.
Description
Technical Field
The invention relates to the technical field of brain-computer interfaces, in particular to a flexible nerve electrode implantation device and system.
Background
Implantable neural electrodes are the most widely used tool in brain-computer interfaces for recording single-cell, sub-millisecond resolution neural activity, and existing implantable neural electrodes include hard silicon-based electrodes and flexible neural electrodes. After the hard silicon-based electrode is implanted, rejection reaction can be caused, peripheral nerve necrosis, chronic inflammation and neuron cell inactivation of an implanted area are caused, and further, signals received by the implantable nerve electrode are degraded along with the time. The flexible nerve electrode has smaller Young modulus, the neuron generation state is good after implantation, and rejection response is little. Therefore, the flexible electrode is the first choice for brain-computer interface.
However, since the young's modulus of the flexible nerve electrode is small, the implantation cannot be performed only by the stiffness of the flexible nerve electrode itself. In addition, since the nerve electrodes are implanted, the skull needs to be removed to expose the brain tissue, and the long-term exposure of the brain tissue increases the risk of surgery and infection. Therefore, there is a need for a flexible neural electrode implant device that can achieve rapid implantation into brain tissue.
Disclosure of Invention
The invention provides a flexible nerve electrode implantation device and a flexible nerve electrode implantation system.
In a first aspect, an embodiment of the present application discloses a flexible neural electrode implantation device, including: the flexible nerve electrode, the fixing frame and the implantation auxiliary component are arranged on the fixing frame;
the flexible nerve electrode comprises an electrode interface unit and at least one flexible nerve probe;
the electrode interface unit is arranged on the fixed frame;
the flexible nerve probe comprises an implantation tail end and an implantation front end, and the implantation tail end is connected with the electrode interface unit;
the implantation auxiliary assembly comprises at least one implantation auxiliary piece, one end of the implantation auxiliary piece is correspondingly connected with the implantation front end one by one, and the implantation auxiliary piece is used for assisting the implantation of the flexible nerve probe;
the implantation auxiliary part is detachably connected with the fixing frame.
Further, the fixing frame comprises a first side surface and a second side surface;
the electrode interface unit is arranged on the first side surface;
the implant aid is removably coupled to the second side.
Furthermore, the connection mode of the electrode interface unit and the first side face is one of bonding, clamping and adsorption connection.
Furthermore, the implantation auxiliary part is connected with the second side surface in one of bonding, clamping and adsorption connection.
Furthermore, a connecting part is arranged at the other end of the implantation auxiliary part and is used for being connected with an implantation tool.
Further, the projection of the connecting portion on the second side surface is at least partially misaligned with the second side surface.
Further, one end of the implantation aid is bonded to the implantation front end by a soluble biocompatible substance.
Furthermore, the implantation front end is provided with a connecting hole, and one end of the implantation auxiliary piece is connected with the implantation front end through the connecting hole.
Furthermore, an implantation part is arranged between the implantation front end and the implantation tail end, and the implantation part is fixed on the electrode interface unit in a folding mode.
Furthermore, a fixing structure is arranged on the fixing frame and used for being connected with the implantation auxiliary equipment.
In a second aspect, embodiments of the present application disclose a flexible nerve electrode implant system, which includes a flexible nerve electrode implant device as described above.
In a third aspect, an embodiment of the present application discloses a flexible neural electrode implantation method, including:
arranging a flexible nerve electrode implantation device in an area to be implanted;
removing the implantation aid from the fixation frame;
implanting an implantation aid into brain tissue of an organism;
and taking the implantation auxiliary component out of the brain tissue of the organism to complete the implantation of the flexible nerve electrode.
By adopting the technical scheme, the technical scheme has the following beneficial effects:
this device is implanted to flexible neural electrode guides the implantation of flexible neural electrode through setting up implantation auxiliary assembly to set up the mount and fix flexible neural electrode and implant auxiliary assembly, can realize the implantation of flexible neural electrode. In addition, the implantation auxiliary part and the flexible nerve probe are pre-assembled together in a one-to-one correspondence mode, the implantation auxiliary part can be directly used for implanting the flexible nerve probe, time consumed by implantation is greatly reduced, implantation efficiency is improved, and implantation safety of the flexible nerve probe is guaranteed.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a flexible nerve electrode implantation device provided by an embodiment of the present application;
fig. 2 is a schematic structural diagram of an implantation assistance assembly according to an embodiment of the present disclosure;
FIG. 3 is a partial schematic view of an implant aid according to an embodiment of the present disclosure coupled to an implant front end;
FIG. 4 is a schematic structural diagram of another flexible neuroprobe implant device according to an embodiment of the present application;
FIG. 5 is a schematic side view of a flexible nerve probe implant device according to an embodiment of the present application;
fig. 6 is a schematic flowchart of a method for implanting a flexible neural electrode according to an embodiment of the present disclosure;
fig. 7 is a schematic structural diagram of an implantation assistance device according to an embodiment of the present application.
The following is a supplementary description of the drawings:
10-a flexible neural electrode; 110-an electrode interface unit; 120-a flexible nerve probe; 121-implant front end; 122-implantation tip; 123-an implant; 20-a fixing frame; 201-a fixed structure; 30-implantation aid assembly; 310-an implantation aid; 311-a connecting part; 40-implantation aid; 401 — connecting arm.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic may be included in at least one implementation of the present application. In the description of the present application, it is to be understood that the terms "upper", "lower", "top", "bottom", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing the present application and simplifying the description, and do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present application. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," and the like are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are capable of operation in sequences other than those illustrated or described herein.
In the prior art, the implantation of the flexible nerve electrode is generally guided by a needle-like guiding device. Specifically, the probe of the flexible nerve electrode is attached to the needle-shaped lead-in device to assist in implanting into the brain tissue, and the needle-shaped lead-in device is recovered after the probe of the flexible nerve electrode is implanted into the brain tissue. This solution is generally only applicable to the case where the flexible nerve electrode only contains one probe, and when the flexible nerve electrode only contains a plurality of probes, the needle-like guide device can be connected with the next probe only after the needle-like guide device is retrieved after the implantation of one probe. As such, implantation takes a significant amount of time, increasing the risk of flexible nerve electrode implantation. In addition, in the case where the flexible nerve electrode includes a plurality of probes, the scattered probes are easily entangled, and thus the probe structure may be damaged.
In view of this, the present application provides a flexible neural electrode implantation device, which can achieve rapid implantation of a flexible neural probe by using a flexible neural probe and an implantation auxiliary member connected in a one-to-one correspondence. And fix flexible neural electrode respectively and implant auxiliary assembly through setting up the mount, isolation and orderliness between each subassembly in can making whole structure to can guarantee the use convenience of flexible neural electrode implantation device, further improve the implantation efficiency who realizes flexible neural electrode.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a flexible neural electrode implantation device according to an embodiment of the present application. As shown in fig. 1, the flexible nerve electrode implant device includes: flexible nerve electrode 10, fixation frame 20 and implantation assistance assembly 30.
In the embodiment of the present application, as shown in fig. 1, the flexible nerve electrode 10 includes an electrode interface unit 110 and at least one flexible nerve probe 120. One or more flexible nerve probes 120 may be included in one flexible nerve electrode 10, and may be specifically configured according to actual needs, which is not limited herein. The flexible nerve probe 120 is made of a flexible material having biocompatibility, such as polyimide, SU8 photoresist, and the like. The flexible nerve probe 120 is provided with an electrode site for collecting electroencephalogram signals. The electrode interface unit 110 is used to connect with a signal processing device, and the electrode interface unit 110 can transmit the electroencephalogram signals collected by the flexible neural probe 120 to the signal processing device for processing. Alternatively, the electrode interface unit 110 may be an integrated chip, or may be an integrated circuit board, such as a Printed circuit board (Printed circuit boards, PCBs), or the like.
In the embodiment of the present application, fig. 2 is a schematic structural diagram of an implantation assistance assembly 30 provided in the embodiment of the present application, and as shown in fig. 2, the implantation assistance assembly 30 includes at least one implantation assistance part 310, and the implantation assistance part 310 is used for assisting in implanting the flexible nerve probe 120. The number of the implantation aids 310 is equal to the number of the flexible nerve probes 120, and they are connected in a one-to-one correspondence. Specifically, the two ends of the flexible nerve probe 120 are respectively an implantation front end 121 and an implantation tail end 122, and the implantation tail end 122 is connected with the electrode interface unit 110, so as to realize the transmission of electroencephalogram signals. Specifically, a metal wire connected to the electrode site is disposed in the flexible nerve probe 120, a metal wire connected to the pad is disposed in the electrode interface unit 110, and the metal wire in the electrode interface unit 110 is connected to the metal wire in the flexible nerve probe 120, so that the flexible nerve probe 120 is connected to the motor interface unit. The implantation front end 121 is connected to one end of the implantation aid 310 so that the implantation aid 310 can guide the flexible nerve probe 120 to be implanted into the brain tissue. To facilitate implantation, the implantation aid 310 may be a needle-like or filament-like structure having a high stiffness. Alternatively, the implantation aid 310 may be an implantation needle made of metal or nonmetal. It should be noted that the material of the implantation needle needs to have non-toxicity or biocompatibility. Optionally, the implant needle may be made of metal such as tungsten and titanium, nonmetal such as silicon and silicon oxide, or organic biological material such as hardened protein and hardened polysaccharide.
As an alternative embodiment, the implantation aid 310 can be adhesively connected to the implantation front 121. Specifically, one end of the implantation aid 310 is bonded to the implantation front end 121 by a soluble biocompatible substance. Alternatively, soluble biocompatible materials include, but are not limited to, proteins, carbohydrates, and the like. The implantation assisting assembly 30 and the implantation front end 121 can be bonded by using biologically metabolizable substances such as protein, saccharides and the like, when the implantation assisting element 310 guides the flexible nerve probe 120 to be implanted into the brain tissue, the soluble biological material with the adhesion function is dissolved by the brain tissue fluid, so that the implantation assisting element 310 is separated from the implantation front end 121, the implantation assisting element 310 can be taken out of the brain tissue, the flexible nerve probe 120 is left in the brain tissue, and the implantation of the flexible nerve probe 120 is realized. In this embodiment, when the implantation aid 310 can be bonded to the implantation front end 121 using the soluble biocompatible substance, a solution of the soluble biocompatible substance is first obtained, and then one end of the implantation aid 310 and the implantation front end 121 of the flexible nerve probe 120 are immersed in the soluble biocompatible solution to be bonded. As an example, one end of the implantation aid 310 and the implantation leading end 121 of the flexible nerve probe 120 are immersed in a solution of a soluble biocompatible substance and the implantation aid 310 and the implantation leading end 121 are brought into contact in the solution of the soluble biocompatible substance, then the implantation aid 310 and the flexible nerve probe 120 are taken out of the solution of the soluble biocompatible substance, and then the solution of the soluble biocompatible substance is subjected to a curing process to cure the solution of the soluble biocompatible substance, thereby adhering one end of the implantation aid 310 and the implantation leading end 121 of the flexible nerve probe 120 together. Alternatively, the soluble biocompatible solution may include, but is not limited to, fibroin solution, collagen solution, polysaccharide solution, polylactic-co-glycolic acid solution, chitosan solution, etc.
It should be understood that the above-mentioned example of bonding one end of the implantation aid 310 and the implantation front end 121 of the flexible nerve probe 120 by immersing them in a soluble biocompatible solution is only one possible example of bonding the implantation aid 310 and the implantation front end 121, and in the practical application, one skilled in the art can bond one end of the implantation aid 310 and the implantation front end 121 of the flexible nerve probe 120 by other methods without creative work.
As another alternative, fig. 3 is a partial structural schematic view illustrating the connection between the implantation aid 310 and the implantation front end 121 according to an embodiment of the present application, as shown in fig. 3, a connection structure may also be disposed on the implantation front end 121 of the flexible nerve probe 120, and the implantation aid 310 is connected to the implantation front end 121 through the connection structure on the implantation front end 121. Specifically, the implantation front end 121 is provided with a coupling hole, and one end of the implantation auxiliary member 310 is coupled to the implantation front end 121 through the coupling hole. As an example, one end of the implantation aid 310 is a tapered end portion, a tip size of the tapered end portion is smaller than a size of the coupling hole on the implantation front end 121, and a tip portion size of the tapered end portion is larger than the size of the coupling hole on the implantation front end 121. The tip of the tapered end portion penetrates through the connection hole on the implantation front end 121, so that the tapered end portion is clamped in the connection hole, and the implantation auxiliary member 310 can drive the flexible nerve probe 120 to move, thereby realizing the implantation of the flexible nerve probe 120. In this embodiment, in order to improve the reliability of the connection of the implantation assistant fitting 310 to the implantation front end 121, after the tapered end portion is inserted through the connection hole, the tapered end portion and the connection hole may be further bonded using a soluble biocompatible material. Alternatively, soluble biocompatible materials include, but are not limited to, proteins, carbohydrates, and the like.
In the embodiment of the present application, as shown in fig. 1, the fixing frame 20 is used to fix the flexible nerve electrode 10 and the implantation assisting assembly 30, so that the flexible nerve electrode 10 and the implantation assisting assembly 30 are fixed together, thereby facilitating the carrying and the transfer, and further improving the convenience of using the flexible nerve electrode 10 and the implantation assisting assembly 30. As an alternative embodiment, the fixing frame 20 may be a fixing plate having a plate-shaped structure. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be respectively disposed on the same side of the fixation plate. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be provided on different sides of the fixation plate, respectively. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be provided on the same side of the fixation plate, respectively. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be provided on different sides of the fixation plate, respectively. As another alternative, the holder 20 may be a fixed box having a box-like structure. Alternatively, the fixing case has at least one side surface, and the flexible nerve electrode 10 and the implantation assistance assembly 30 may be respectively disposed on the side surfaces of the fixing case. Specifically, as an example, the fixing case is a cylindrical case assembly structure having one side surface on which the flexible nerve electrode 10 and the implantation assistance assembly 30 may be respectively disposed. As another example, the stationary box is a box-like structure having two sides. Optionally, both sides may be curved. Optionally, one side surface of the two side surfaces may be a curved surface, and the other side surface may be a flat surface. As another example, the fixing box is a box-shaped structure having three or more sides. Alternatively, the side surfaces may be both curved surfaces or both flat surfaces. Optionally, the side surfaces may be a part of the side surfaces which are curved surfaces, and a part of the side surfaces which are flat surfaces. Optionally, the curved surface in the above example may be a circular arc surface. As another example, the mounting box also has a top surface and/or a bottom surface. Alternatively, the flexible nerve electrode 10 and the implant assist assembly 30 may be disposed on the top and bottom surfaces, respectively. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be provided on the top surface and the side surface, respectively. Alternatively, the flexible nerve electrode 10 and the implantation assistance assembly 30 may be provided on the bottom surface and the side surface, respectively. Alternatively, the flexible neural electrode 10 and the implantation assistance assembly 30 may be provided on the top surface and/or the ground at the same time.
In some embodiments, the fixture 20 may also be the electrode interface unit 110 itself. As an example, the electrode interface unit 110 is a PCB board, one surface of which may be provided with pads for connecting electronic components, and the other surface of which may be used for connecting the implantation assistance assembly 30. As another example, the electrode interface unit 110 has a housing, and the implantation assistance assembly 30 may also be disposed on the housing of the electrode interface unit 110.
In the embodiment of the present application, as shown in fig. 1, the fixing structure 201 is further disposed on the fixing frame 20, and the fixing structure 201 is used for connecting with the implantation assisting device 40. In particular, the implantation assistance device 40 is used to secure a flexible nerve electrode implant assembly. Alternatively, the implantation assisting device 40 may be a suspension frame, a support frame, a robot arm of a surgical robot, or the like. As shown in fig. 1, the fixing structure 201 may be a connection column, and a fixing hole is formed on the connection column. In some embodiments, the fixing structure 201 may also be other structures, such as hooks, slots, and the like. The specific arrangement of the fixing structure 201 is not limited to a large extent.
In the embodiment of the present application, when the fixing frame 20 is a fixing box having two or more side surfaces, the flexible nerve electrode 10 and the implantation assisting assembly 30 may be respectively disposed on the same side surface of the fixing box, or may be respectively disposed on different side surfaces of the fixing box. As an example, the holder 20 is a fixed box including a first side and a second side. The first side surface may be a plane surface and the second side surface may be a circular arc surface. Electrode interface unit 110 is disposed on a first side and implant assist assembly 30 is removably disposed on a second side. As another example, fig. 4 is a schematic structural diagram of another flexible neural probe 120 implantation device provided in this embodiment of the present application, and as shown in fig. 4, the fixing frame 20 is a fixing box, and the fixing box includes a first side and a second side. The first side surface and the second side surface are planes, the first side surface and the second side surface are arranged asymmetrically, namely the first side surface is arranged obliquely relative to the second side surface, and an included angle is formed by the extension of the first side surface and the extension of the second side surface. Electrode interface unit 110 is disposed on a first side and implant assist assembly 30 is removably disposed on a second side.
In the present embodiment, an implant portion 123 is located between the implant front end 121 and the implant tail end 122 of the flexible neural probe 120. In some cases, the flexible nerve probe 120 may have a long length, and if the flexible nerve probe 120 is not fixed, in the case that the flexible nerve electrode 10 includes a plurality of flexible nerve probes 120, the implant portion 123 of the flexible nerve probe 120 may be entangled, which may affect the implantation efficiency of the flexible nerve electrode 10. Fig. 5 is a schematic side view of a flexible nerve probe 120 implantation device according to an embodiment of the present invention, and as shown in fig. 5, the flexible nerve probe 120 implantation device according to an embodiment of the present invention employs a folding structure to fix an implant portion 123 on an electrode interface unit 110, so that the implant portions 123 of a plurality of flexible nerve probes 120 can be prevented from being twisted together, and thus the implantation efficiency of the flexible nerve electrode 10 can be improved. Alternatively, the implant 123 may be folded and fixed by means of adhesion. In some embodiments, the implant 123 may also be folded and fixed by means of a snap-fit.
In the embodiment of the present application, as shown in fig. 1, the connection manner between the electrode interface unit 110 and the fixing frame 20 may be a fixed connection or a detachable connection. Alternatively, the electrode interface unit 110 may be detachably provided on the fixing frame 20. Optionally, the connection mode between the electrode interface unit 110 and the fixing frame 20 may be one of adhesion, clamping, adsorption connection, and screw fixation connection. Alternatively, the suction connection includes, but is not limited to, magnetic suction, negative pressure system suction, and the like. As an example, the fixing frame 20 may be provided with an electrode interface unit fixing structure, such as a mounting hole, through which the electrode interface unit 110 is fixed on the fixing frame 20.
In the present embodiment, as shown in fig. 1, each of the implantation aids 310 in the implantation aid assembly 30 may be detachably provided directly on the holder 20. Alternatively, a plurality of implant aids 310 can be disposed on the fixation frame 20 in a uniform or non-uniform manner. The above-mentioned detachable means that the implantation aid 310 can be directly detached from the holder 20 without using a detaching tool, that is, when the implantation aid 310 is subjected to a peeling force, the implantation aid 310 can be detached from the holder 20, thereby facilitating the operation during implantation and reducing the time taken for implantation. Alternatively, the connection between the implantation aid 310 and the fixation frame 20 may be one of an adhesive, a snap, and an absorption connection. As an example, the surface of holder 20 on which implant aid assembly 30 is attached has adhesive properties, and a plurality of implant aids 310 are positioned side-by-side on this surface. As another example, holder 20 may be provided with an implant aid 310 attachment structure, such as a slot, through which electrode interface unit 110 is attached to holder 20. Alternatively, the attachment of multiple implant aids 310 to fixation frame 20 may or may not be the same. For example, portions of implant aid 310 can be adhesively attached to holder 20, and portions of implant aid 310 can be adhesively attached to holder 20. In some embodiments, implant assist elements 310 in implant assist assembly 30 can also be pre-secured by a connector that is then connected to holder 20. Optionally, the implantation aid 310 is removably attached to the connector.
It should be noted that, when the implantation assistance assembly 30 includes a plurality of implantation assistance parts 310, the plurality of implantation assistance parts 310 are arranged on the fixing frame 20 according to the arrangement order of the flexible neural probe 120 connected thereto in the electrode interface unit 110, so as to avoid the flexible neural probe 120 from being entangled and affecting the implantation operation efficiency.
In the embodiment of the present application, as shown in fig. 1 and 2, a connection part 311 is provided on the other end of the implantation aid 310, and the connection part 311 is used for connecting with an implantation tool. Alternatively, the implantation tool includes, but is not limited to, forceps, a holding arm or a suction arm of a surgical robot, and the like. The implantation tool may peel the implantation aid 310 off of the holder 20 and implant into a specific area of biological tissue. In an alternative embodiment, the connection portion 311 is flat with a flat surface, and one end of the implantation tool is a vacuum tube, and the vacuum tube is aligned with the flat surface of the connection portion 311 and then vacuumized, so that the implantation tool can form a fixed connection with the implantation aid 310. To facilitate the attachment of the implantation tool to the attachment portion 311 and thus the removal of the implantation aid 310 from the holder 20, the projection of the attachment portion 311 onto the second side is at least partially offset from the second side. That is, the connecting portion 311 is shielded by the structure in the fixing frame 20, the implantation tool can be directly connected to the connecting portion 311 without adjusting the position of the fixing frame 20 or the implantation assistant member 310.
In the embodiment of the present application, since the implantation aids 310 are used to implant the flexible neural electrode 10 into the brain tissue of a living body, and the implantation aids 310 themselves are easily damaged, a protective film may be disposed on each implantation aid 310 to protect the implantation aid 310. Alternatively, the protective film may be a protective sticker. In some embodiments, the protective membrane may also be integrally disposed over the entire implant assist assembly 30.
The embodiment of the application also provides a flexible nerve electrode 10 implantation system, which comprises the flexible nerve electrode implantation device.
In the embodiment of the present application, the flexible nerve electrode 10 implantation system may further include an implantation assisting device 40, an implantation tool, and the like, in addition to the flexible nerve electrode implantation apparatus described above.
An embodiment of the present application further provides an implantation method of the flexible neural electrode 10, and fig. 6 is a schematic flow chart of the implantation method of the flexible neural electrode 10 provided in the embodiment of the present application, and as shown in fig. 6, the method may include:
s601: a flexible nerve electrode implant device is positioned at the area to be implanted.
In the embodiment of the present application, before the flexible neural electrode 10 is implanted into the brain tissue of the living body, it is necessary to first perform a craniotomy on the living body according to the site to be implanted, thereby exposing the brain tissue of the living body. The region to be implanted refers to a region near the brain of the organism to be implanted. The flexible nerve electrode implant device may be secured to the implantation aid 40 so that the implantation aid 40 may move the flexible nerve electrode implant device to the area to be implanted. The implantation assistance apparatus 40 is used to fix the flexible nerve electrode implant device. Alternatively, the implantation assisting device 40 may be a suspension frame, a support frame, a robot arm of a surgical robot, or the like. As an example, fig. 7 is a schematic structural diagram of an implantation assisting apparatus 40 provided in an embodiment of the present application, and as shown in fig. 7, an attachment arm 401 capable of being attached to a fixture 20 of a flexible nerve electrode implantation device is provided on the implantation assisting apparatus 40, and a fixing structure 201 on the fixture 20 can be in matching connection with the attachment arm 401, so that the flexible nerve electrode implantation device can be fixed on the implantation assisting apparatus 40.
S603: the implantation aid 310 is removed from the holder 20.
In the embodiment of the present application, the flexible nerve electrode implanting device includes an implantation assisting assembly 30, a fixing frame 20, and a flexible nerve electrode 10. The flexible nerve electrode 10 includes one to a plurality of flexible nerve probes 120, the implantation assistance assembly 30 includes the same number of implantation assistance pieces 310 as the number of the flexible nerve probes 120, and the implantation assistance pieces 310 are connected to the flexible nerve probes 120 in a one-to-one correspondence. The implantation aid 310 is detachably arranged on the holder 20 together with the holder 20. When the flexible nerve electrode 10 is implanted into the brain tissue of a living body, the implantation aid 310 may be removed from the fixing frame 20 and then an implantation operation may be performed. During this process, implant aid 310 can be peeled away from holder 20 using an implant tool. A coupling part 311 is provided at the other end of the implantation aid 310, and the coupling part 311 is used to couple with an implantation tool. Alternatively, the implantation tool includes, but is not limited to, forceps, a holding arm or a suction arm of a surgical robot, and the like.
S605: the implantation aid 310 is implanted into the brain tissue of an organism.
In the present embodiment, the implantation front end 121 of the flexible nerve probe 120 is connected to one end of the implantation aid 310, so that the implantation aid 310 can be implanted into the brain tissue of the living body with the flexible nerve probe 120.
S607: the implantation aid 310 is removed from the brain tissue of the living body, completing the implantation of the flexible nerve electrode 10.
In the embodiment of the present application, the implantation aid 310 and the flexible nerve probe 120 are bonded by a soluble biocompatible material, or connected by a connection structure on the implantation front end 121. As an alternative embodiment, in the case that the implantation aid 310 and the flexible nerve probe 120 are connected by adhesion of a soluble biocompatible material, after the implantation aid 310 is implanted into the brain tissue of the living body, the soluble biocompatible material is dissolved by tissue fluid in the brain tissue of the living body after a predetermined time, so that the implantation aid 310 is separated from the flexible nerve probe 120, and then the implantation aid 310 may be removed from the brain tissue of the living body while the flexible nerve probe 120 is left in the brain tissue, so that the implantation of the flexible nerve probe 120 connected thereto is completed, and then the implantation of the next implantation aid 310 may be performed. In order to further reduce the time taken for implanting the flexible nerve electrode 10, after one implantation aid 310 is implanted into the brain tissue of the living body, the implantation aid 310 may not be removed from the brain tissue of the living body, but the implantation of the next implantation aid 310 may be directly performed. After all the implantation aids 310 are implanted, the implantation aids 310 are taken out from the brain tissue of the living body one by one, so that the time consumed by the tissue fluid in the brain tissue of the living body to dissolve the soluble biocompatible substances can be saved, and the implantation efficiency is further improved. As another alternative embodiment, in the case where the implantation assisting element 310 and the flexible nerve probe 120 are connected by the connection structure on the implantation front end 121, after the implantation assisting element 310 is implanted into the brain tissue of the living body, the implantation assisting element 310 may be directly taken out from the brain tissue of the living body, or after all the implantation assisting elements 310 are implanted into the brain tissue of the living body, the implantation assisting elements 310 may be taken out from the brain tissue of the living body one by one.
In the embodiment of the present application, after all the implantation aids 310 are implanted, the electrode interface unit 110 of the flexible nerve electrode 10 can be detached from the fixing frame 20, so that the fixing frame 20 can be recycled as a recyclable component.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (11)
1. A flexible neural electrode implant device, comprising: the flexible nerve electrode (10), the fixing frame (20) and the implantation auxiliary assembly (30);
the flexible neural electrode (10) comprises an electrode interface unit (110) and at least one flexible neural probe (120);
the electrode interface unit (110) is arranged on the fixing frame (20);
the flexible neural probe (120) comprises an implantation tip (122) and an implantation front end (121), the implantation tip (122) being connected with the electrode interface unit (110);
the implantation auxiliary assembly (30) comprises at least one implantation auxiliary piece (310), one end of the implantation auxiliary piece (310) is connected with the implantation front end (121) in a one-to-one correspondence mode, and the implantation auxiliary piece (310) is used for assisting the implantation of the flexible nerve probe (120);
the implantation aid (310) is detachably connected to the holder (20).
2. The flexible neural electrode implant device of claim 1, wherein the anchor (20) includes a first side and a second side;
the electrode interface unit (110) is disposed on the first side;
the implantation aid (310) is removably coupled to the second side.
3. The flexible neural electrode implant device of claim 2, wherein the electrode interface unit (110) is attached to the first side surface in one of an adhesive, a snap-fit, and an adhesive attachment.
4. The flexible neural electrode implant device of claim 2, wherein the implant aid (310) is attached to the second side surface by one of an adhesive, a snap-fit, and a suction attachment.
5. The flexible nerve electrode implant device according to claim 2, characterized in that a connecting part (311) is provided on the other end of the implant aid (310), the connecting part (311) being used for connecting with an implant tool.
6. The flexible nerve electrode implant device according to claim 5, characterized in that the projection of the connection portion (311) on the second side is at least partially non-coincident with the second side.
7. The flexible nerve electrode implant device of claim 1, wherein one end of the implant aid (310) is bonded to the implant front end (121) by a soluble biocompatible substance.
8. The flexible nerve electrode implanting device according to claim 1, wherein the implanting front end (121) is provided with a connecting hole, and one end of the implanting auxiliary member (310) is connected with the implanting front end (121) through the connecting hole.
9. The flexible nerve electrode implant device according to any one of claims 1 to 8, characterized in that between the implant front end (121) and the implant tip (122) is an implant part (123), the implant part (123) being folded and fixed on the electrode interface unit (110).
10. The flexible neural electrode implant device as claimed in any one of claims 1 to 8, wherein the fixture (20) is provided with a fixture (201), and the fixture (201) is used for connecting with an implant aid (40).
11. A flexible nerve electrode (10) implant system, characterized in that the system comprises a flexible nerve electrode implant device according to any one of claims 1-10.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116616780A (en) * | 2023-04-19 | 2023-08-22 | 上海脑虎科技有限公司 | Flexible electrode and preparation method thereof |
| CN117481764A (en) * | 2023-12-28 | 2024-02-02 | 北京智冉医疗科技有限公司 | Flexible electrode auxiliary implantation device |
| CN117679034A (en) * | 2024-02-04 | 2024-03-12 | 北京智冉医疗科技有限公司 | Auxiliary implantation assembly and implantation system of flexible nerve electrode |
| CN117942144A (en) * | 2024-03-27 | 2024-04-30 | 北京智冉医疗科技有限公司 | Electrode implantation mechanism and electrode implantation device with same |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102277297A (en) * | 2011-08-16 | 2011-12-14 | 中国科学院深圳先进技术研究院 | Implanted in vivo electrotransfection device |
| CN108903916A (en) * | 2018-07-31 | 2018-11-30 | 浙江大学 | The implant needle and method for implantation of flexible implanted biosensor and photoelectric device |
| CN110870846A (en) * | 2018-08-31 | 2020-03-10 | 中科微针（北京）科技有限公司 | Rapidly implantable sustained-release microneedle patch and preparation method thereof |
| CN112244850A (en) * | 2020-09-29 | 2021-01-22 | 中国科学院上海微系统与信息技术研究所 | Intracranial deep electrode recording device and preparation method and system thereof |
| CN112999511A (en) * | 2021-03-10 | 2021-06-22 | 中国科学院半导体研究所 | Flexible electrode lead-in device |
| CN114469117A (en) * | 2022-02-25 | 2022-05-13 | 武汉衷华脑机融合科技发展有限公司 | Neural interface with degradable coating |
| CN114631822A (en) * | 2022-02-17 | 2022-06-17 | 上海脑虎科技有限公司 | Flexible nerve electrode, preparation method and equipment |
| CN114788700A (en) * | 2022-02-25 | 2022-07-26 | 武汉衷华脑机融合科技发展有限公司 | Neural interface with auxiliary structure |
| CN114796858A (en) * | 2022-06-29 | 2022-07-29 | 中国科学院自动化研究所 | Flexible electrode implantation method, device, equipment and storage medium |
| CN114947869A (en) * | 2021-02-25 | 2022-08-30 | 哈尔滨工业大学 | Flexible neural electrode assisted implantation system and method with integrated sensing needle tip |
| CN114950858A (en) * | 2022-05-24 | 2022-08-30 | 中国科学院自动化研究所 | Dispensing device and implantation system of flexible electrode |
| CN114948232A (en) * | 2021-02-22 | 2022-08-30 | 哈尔滨工业大学 | Flexible nerve electrode implantation surgical robot and control method |
-
2022
- 2022-09-08 CN CN202211098005.3A patent/CN115644881B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102277297A (en) * | 2011-08-16 | 2011-12-14 | 中国科学院深圳先进技术研究院 | Implanted in vivo electrotransfection device |
| CN108903916A (en) * | 2018-07-31 | 2018-11-30 | 浙江大学 | The implant needle and method for implantation of flexible implanted biosensor and photoelectric device |
| CN110870846A (en) * | 2018-08-31 | 2020-03-10 | 中科微针（北京）科技有限公司 | Rapidly implantable sustained-release microneedle patch and preparation method thereof |
| CN112244850A (en) * | 2020-09-29 | 2021-01-22 | 中国科学院上海微系统与信息技术研究所 | Intracranial deep electrode recording device and preparation method and system thereof |
| CN114948232A (en) * | 2021-02-22 | 2022-08-30 | 哈尔滨工业大学 | Flexible nerve electrode implantation surgical robot and control method |
| CN114947869A (en) * | 2021-02-25 | 2022-08-30 | 哈尔滨工业大学 | Flexible neural electrode assisted implantation system and method with integrated sensing needle tip |
| CN112999511A (en) * | 2021-03-10 | 2021-06-22 | 中国科学院半导体研究所 | Flexible electrode lead-in device |
| CN114631822A (en) * | 2022-02-17 | 2022-06-17 | 上海脑虎科技有限公司 | Flexible nerve electrode, preparation method and equipment |
| CN114469117A (en) * | 2022-02-25 | 2022-05-13 | 武汉衷华脑机融合科技发展有限公司 | Neural interface with degradable coating |
| CN114788700A (en) * | 2022-02-25 | 2022-07-26 | 武汉衷华脑机融合科技发展有限公司 | Neural interface with auxiliary structure |
| CN114950858A (en) * | 2022-05-24 | 2022-08-30 | 中国科学院自动化研究所 | Dispensing device and implantation system of flexible electrode |
| CN114796858A (en) * | 2022-06-29 | 2022-07-29 | 中国科学院自动化研究所 | Flexible electrode implantation method, device, equipment and storage medium |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116616780A (en) * | 2023-04-19 | 2023-08-22 | 上海脑虎科技有限公司 | Flexible electrode and preparation method thereof |
| CN117481764A (en) * | 2023-12-28 | 2024-02-02 | 北京智冉医疗科技有限公司 | Flexible electrode auxiliary implantation device |
| CN117481764B (en) * | 2023-12-28 | 2024-04-19 | 北京智冉医疗科技有限公司 | Flexible electrode auxiliary implantation device |
| CN117679034A (en) * | 2024-02-04 | 2024-03-12 | 北京智冉医疗科技有限公司 | Auxiliary implantation assembly and implantation system of flexible nerve electrode |
| CN117679034B (en) * | 2024-02-04 | 2024-05-03 | 北京智冉医疗科技有限公司 | Auxiliary implantation assembly and implantation system of flexible nerve electrode |
| CN117942144A (en) * | 2024-03-27 | 2024-04-30 | 北京智冉医疗科技有限公司 | Electrode implantation mechanism and electrode implantation device with same |
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