CN115633687A - Composition for preventing and treating mites, insects and nematodes and application - Google Patents
Composition for preventing and treating mites, insects and nematodes and application Download PDFInfo
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- CN115633687A CN115633687A CN202110813291.6A CN202110813291A CN115633687A CN 115633687 A CN115633687 A CN 115633687A CN 202110813291 A CN202110813291 A CN 202110813291A CN 115633687 A CN115633687 A CN 115633687A
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Abstract
The invention relates to binary compositions comprising a compound of formula (A-I) and another active ingredient; and methods of controlling or preventing plant damage and animal infection; and formulations, concentrates and seed treatments comprising such combinations.
Description
Technical Field
The present invention relates to compositions primarily for controlling damage caused by acarina and other pests and/or nematodes, especially damage to plants and animals.
Background
The present invention describes certain active ingredients and combinations of active ingredients for controlling pest infestation. A series of insecticidal and acaricidal compositions are provided which are significantly improved in terms of, for example, biological properties, synergistic properties, and particularly in controlling pests, mites and nematodes. In addition, safety, physicochemical properties, biodegradability and the like are also improved.
The research shows that when the composition with specific active ingredients is applied to plants, animals or relevant places thereof, the specific combination is used for controlling harm to the plants or the animals, and an unexpected prevention and control effect is generated.
Disclosure of Invention
The present invention provides a composition comprising as component (a) a compound of formula (a-I):
or a salt thereof
And as component (B) one or more compounds selected from the group consisting of:
b-1[3- (2, 4-dichlorophenyl) -2-oxo-1-oxaspiro [4.5] dec-3-en-4-yl ] carbonate butyl ester (CAS 1305319-70-3)
B-2 Fluthrin (CAS 101007-06-1)
B-3 fenazaquin (CAS 120928-09-8)
B-4Flipper TM (contact biological insecticide/acaricide containing C7-C20 fatty acid)
B-5N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl ] phenyl ] methyl ] cyclopropanecarboxamide (CAS 1365070-72-9)
B-6 (S) -N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl ] phenyl ] methyl ] cyclopropanecarboxamide (CAS 2044701-44-0)
B-7Fluxametamide(CAS 928783-29-3)
B-8Spidoxamat(CAS 907187-07-9)
B-9 Bromocha-Fluorobene bisamide (CAS 1207727-04-5)
B-10Nicofluprole(CAS 1771741-86-6)
B-11 Cyclopropanflufenoxuron (CAS 2375110-88-4)
B-12- [ [3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichloro-cyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide (CAS 2220132-55-6)
B-13- [ [ (1R, 3R) -3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichloro-cyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide)
B-14- [ [ (1S, 3S) -3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichloro-cyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide)
B-15 Tetrachlorfenapyr benzamide (CAS 1104384-14-6)
B-16Afidopyropen(CAS 915972-17-7)
B-17-dimethyl-2- [2- (3-pyridinyl) indazol-5-yl ] -1,2, 4-triazolidine-3, 5-dione
B-18N- [ 3-chloro-1- (3-pyridinyl) pyrazol-4-yl ] -2-methanesulfonyl-propionamide (CAS 2396747-83-2)
B-19 Tyclopyrazoflor(CAS 1477919-27-9)
B-20N- (1-methylcyclopropyl) -2- (3-pyridyl) indazole-4-carboxamide (CAS 1689545-27-4)
B-21 Dimppyridaz (chemical abstractor No. 1403615-77-9)
B-22 flonicamid (CAS 158062-67-0)
B-23 Pyrifluquinazon(CAS 337458-27-2)
B-24 pymetrozine (CAS 123312-89-0)
B-25 fipronil (CAS 120068-37-3)
B-26- (2-Chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol salt (CAS 2413839-57-1)
B-27 (3R) -3- (2-Chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (CAS 2413390-32-4)
B-28 (3R) -3- (2-Chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (enolate tautomer) (CAS 2413839-58-2)
B-29 (3R) -3- (2-Chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (dione) (CAS 2246757-58-2)
B-30 Trifluoropyrimidine (CAS 1263133-33-0)
B-31- (2-cyanoethyl) -4-oxo-3- [3- (trifluoromethyl) phenyl ] pyrido [1,2-a ] pyrimidin-1-2-ium-2-ol (CAS 2032403-97-5)
B-32 Chlorothiapyrantel (CAS 1263629-39-5)
B-33 Imidacloprid (CAS 138261-41-3)
B-34 Fluopyranone (CAS 951659-40-8)
B-35 Thiacloprid (CAS 111988-49-9)
B-36 sulfoxaflor (CAS 946578-00-3)
B-37 acetamiprid (CAS 135410-20-7)
B-38Flupyrimin(CAS 1363400-41-2)
B-39 dinotefuran (CAS 165252-70-0)
B-40 nitenpyram (CAS 150824-47-8)
B-41 clothianidin (CAS 210880-92-5)
B-42 thiamethoxam (CAS 153719-23-4)
B-43 Tetratolanilide (CAS 1229654-66-3)
B-44 Flubendiamide (CAS 272451-65-7)
B-45 Chlorantraniliprole (CAS 500008-45-7)
B-46 Cyantraniliprole (CAS 736994-63-1)
B-47-bromo-2- (3-chloro-2-pyridinyl) -N- [4, 6-dichloro-3-fluoro-2- (methylcarbamoyl) phenyl ] pyrazole-3-carboxamide (CAS 2129147-03-9)
B-48 Cyclobromantraniliprole (CAS 1031756-98-5)
B-49 Cyhalodiamide (CAS 1262605-53-7)
B-50-bromo-2- (3-chloro-2-pyridinyl) -N- [2, 4-dichloro-6- (isopropylaminomethionyl) phenyl ] pyrazole-3-carboxamide (CAS 1442448-92-1)
B-51- [6- (2, 2-difluoro-7-methyl- [1,3] dioxolo [4,5-f ] benzimidazol-6-yl) -5-ethanesulfonyl-3-pyridinyl ] cyclopropanecarbonitrile (CAS 2408220-94-8)
B-52- (5-cyclopropyl-3-ethylsulfonyl-2-pyridyl) -2, 2-difluoro-7-methyl- [1,3] dioxolo [4,5-f ] benzimidazole (CAS 2408220-91-5)
B-53 2- (5-cyclopropyl-3-ethanesulfonyl-2-pyridyl) -5- (trifluoromethylsulfonyl) -1, 3-benzoxazole
B-54 2- [ 3-ethylsulfonyl-5- (trifluoromethyl) pyrazolo [1,5-a ] pyridin-2-yl ] -3-methyl-6- (trifluoromethyl) imidazo [4,5-B ] pyridine (CAS 2133042-44-9)
B-55- [ 3-ethylsulfonyl-6- (trifluoromethyl) pyrazolo [1,5-a ] pyridin-2-yl ] -3-methyl-6- (trifluoromethyl) imidazo [4,5-B ] pyridine (CAS 2133042-31-4)
B-56- [ 3-ethylsulfonyl-6- (1, 2, 4-triazol-1-yl) -2-pyridinyl ] -3-methyl-6- (trifluoromethyl) imidazo [4,5-B ] pyridine (CAS 1808115-49-2)
B-57 2- (3-ethylsulfonyl-2-pyridyl) -5- (2, 3-pentafluoropropoxy) pyrazine (CAS 2095470-94-1)
B-58 Oxazosulfyl(CAS 1616678-32-0)
B-59 Benzpyrimoxan(CAS 1449021-97-9)
B-60 indoxacarb (CAS 173584-44-6)
B-61 metaflumizone (CAS 139968-49-3)
B-62 deltamethrin (CAS 52918-63-5)
B-63 bifenthrin (CAS 82657-04-3)
B-64 efficient cyhalothrin (CAS 76703-62-3)
B-65 beta-cypermethrin (CAS 1315501-18-8)
B-66 alpha-cypermethrin (CAS 67375-30-8)
B-67 fenvalerate (CAS 51630-58-1)
B-68 cis-fenvalerate B-68 (CAS 66230-04-4)
B-69 cyhalothrin (CAS 91465-08-6)
B-70 tefluthrin (CAS 79538-32-2)
B-71 (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one
B-72 (R) - (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one
B-73- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 1445684-82-1)
B-74 Flupentiofenox(CAS 1472050-04-6)
B-75 Flufenerim(CAS 170015-32-4)
B-76 fluhexafon(CAS 1097630-26-6)
B-77 methoxyfenozide (CAS 161050-58-4)
B-78 tebufenozide (CAS 112410-23-8)
B-79 Fluopyram(CAS 658066-35-4)
B-80 Fluazaindolizine(CAS 1254304-22-7)
B-81 Guadipyr(CAS 1227849-60-6)
B-82 Triflupirtine Ether (CAS 179101-81-6)
B-83, 4-Trifluorobut-3-enyl 2- (2-methoxyphenyl) -5-oxo-tetrahydrofuran-3-carboxylate (CAS 2074661-82-6)
B-84 Tioxazafen(CAS 330459-31-9)
B-85 Afoxolaner(CAS 1093861-60-9)
B-86 Fluralaner(CAS 864731-61-3)
B-87 Sarolaner(CAS 1398609-39-6)
B-88Tigolaner (CAS 1621436-41-6) or a salt thereof.
Secondly, the present invention also provides a method for controlling or combating insect pests on plants, which method comprises applying to the plants or to the respective habitat the different components of a composition comprising, as component (a), a compound of formula (a-I) as defined above or an agrochemically acceptable salt thereof, and as component (B), one or more compounds selected from B-1 to B-84 as defined above or an agrochemically acceptable salt thereof, simultaneously or in any desired order.
In some embodiments of the invention as described above, it is preferred that component (B) is selected from compounds B-1 to B-82 as defined above.
In some embodiments of the invention as described above, it is preferred that component (B) is selected from compounds B-1 to B-70 as defined above.
In some embodiments of the present invention as described above, it is most preferred that component (B) comprises a compound selected from compounds B-1 to B-15 as defined above.
In a third aspect, the present invention provides a method of controlling or combating pests, which comprises applying to an animal or to a corresponding habitat different components of a composition comprising as components (a) a compound of formula (a-I) as defined above or an acceptable salt thereof, and (B) at least one compound selected from compounds B-85 to B-88 as defined above or an acceptable salt thereof, simultaneously or in any desired order.
In a fourth aspect, the composition of the invention, comprising as component (a) a compound of formula (a-I) as defined above or an acceptable salt thereof, and as component (B) at least one compound selected from the compounds B-85 to B-88 as defined above, or an acceptable salt thereof, for use in the hygiene control of animals.
In a fifth aspect, the composition of the invention is useful as an acaricide and/or miticide and a nematicide and/or insecticide.
In a sixth aspect, the composition of the present invention comprises 0.01 to 90% by mass of the active ingredient, 0 to 25% by mass of an agriculturally or pharmaceutically acceptable surfactant, and 10 to 99.9% by mass of solid or liquid formulation inert materials and adjuvants.
In a seventh aspect, the present invention provides a concentrate composition for dilution by a user, the concentrate composition comprising the composition of the present invention in a concentration range of 2-80% by mass, preferably in a concentration range of 5-70% by mass.
In an eighth aspect, the present invention also provides the use of a combination or composition as defined above for controlling acarids or acarids and insect and/or nematode pests.
The compositions and combinations of the present invention further comprise one or more adjuvants and/or diluents.
The mass fraction ratio of the combination of component (A) such as the compound of formula (A-I) and each compound of component (B) is in the range of 500: 1 to 1: 500, 100: 1 to 1: 100, 50:1 to 1: 50 or 20: 1 to 1: 20, preferably 10: 1 to 1: 10 or 5: 1 to 1: 5, or 3: 1 to 1: 3, with some specific ratios in the range of 2: 1 to 1: 2, most preferably 1: 1.
In addition to any synergistic effect, the compositions of the present invention may also achieve other unexpected advantageous properties. Including more favorable degradability, improved toxicology and/or ecotoxicology behavior, or improved characteristics of useful plants, including emergence of seedlings, crop yield, more developed root systems, increased tillering, increased plant height, larger leaves, less dead leaves at the base, stronger tillering, darker leaves, reduced fertilizer usage, saved seeds, more tillering, earlier flowering, earlier kernel maturation, less lodging of the plants, increased growth of new shoots, improved plant vigor, and early germination.
Certain weight ratios of component (a) to component (B) may produce synergistic activity. Further, the present invention provides a composition wherein component (a) and component (B) are present in the composition in amounts that produce a synergistic effect. This synergistic activity is evident because the activity of the composition comprising component (a) and component (B) is greater than the sum of the respective activities of component (a) and component (B) alone. The synergistic effect of component (A) and component (B) is thus manifested in two ways. First, the amounts of component (a) and component (B) can be reduced, and even when the effects of the two components used alone are low, pest control can be achieved. Second, the range of pests that can be controlled is expanded.
The active ingredients of the combination of the invention may be applied to the pests, plants and their habitat simultaneously (e.g. as a pre-formulated mixture or tank mix) or in a suitable order.
The compositions, i.e. components (a) and (B), can be used as pure active ingredients or, preferably, are formulated with at least one adjuvant, also known as adjuvant, for example a synergist, a solvent or a solid carrier, or a surface-active compound (surfactant) components (a) and (B) as described herein, usually in the form of a formulation, each containing one or more customary formulation auxiliaries.
Also, the components (A) and (B) may be used in the form of separate preparations. The application to the plants to be controlled and their habitat can be carried out simultaneously or successively at short intervals, for example on the same day, if desired together with further carriers, surfactants or other application-promoting adjuvants customarily employed in formulation technology. In a preferred embodiment, both (a) and (B) are applied simultaneously. An additional benefit of the co-or simultaneous application of components (a) and (B) is that the time for the farmer to apply the product to the crop is reduced. Compositions described for the present invention may also include specific plant traits incorporated into plants using any method, such as conventional breeding or genetic modification.
When the compounds of components (a) and (B) of the compositions of the present invention are applied simultaneously, they may be applied in combination as a composition comprising components (a) and (B), and in some cases, components (a) and (B) may be derived from separate formulations and mixed together (known as tank mixing, premixing, simultaneous spraying). Components (a) and (B) may be combined as a single formulation, optionally with other insecticides (known as premixes, concentrates, formulations) and optionally with other pesticides.
In such embodiments, the formulation of the composition comprises agriculturally acceptable adjuvants. Further, the present invention provides a composition comprising component (a), component (B) and an agriculturally acceptable adjuvant. The formulations of the compositions of the present invention include, among other things, the usual formulation adjuvants, such as carriers, solvents and Surfactants (SFAs)
The compositions of the present invention are effective in controlling pests, increasing tolerance of crop plants to abiotic stress conditions, and/or increasing yield of crop plants. In certain embodiments, the compositions of the present invention are effective against insect and/or acarina pests and/or nematode pests. The present invention provides a method for controlling pests in or on crops of plants, to increase the tolerance of crop plants to abiotic stress conditions, and/or to increase the yield of crop plants, said method comprising a method for treating pests, plants, plant parts, plant propagation material or the habitat thereof.
The compositions of the present invention are useful for extending the duration of protection of plants and their habitat. In certain embodiments, the compositions of the present invention may exhibit both a better rapid onset of action and a better sustained protective effect.
The compositions of the present invention can be used to extend the range of crops that can be used and/or to extend the range of pests that the compositions provide effective control.
Accordingly, the compositions of the present invention exhibit enhanced biological characteristics, including an expanded pesticidal spectrum and/or complementation of mechanisms of action. More particularly, the component (a) compound and the component (B) compound may exhibit complementary migratory properties in plants. In certain specific compositions, the compound of component (a) has a systemic activity in plants compared to that of component (B), so that the compound of component (a) can provide more effective protection to plants.
In other compositions, the component (a) compounds have a certain ability to move upwards in the plant compared to the component (B) compounds, so that the component (a) compounds can provide more effective protection.
As appears in the context of the present invention, the sequence of numbers following "CAS" refers to the chemical literacy notation of the active ingredient. The generic names of the active ingredients, which appear in the text of the present invention, are expressed in terms of "ISO 1750-1981-pesticides and other agrochemicals-generic name", where available or known.
Said compounds of formula (A-I) are described in patents CN 105541682 and WO 2017/067500.
The compounds B-1 to B-88 of component B are known compounds having insecticidal, nematicidal and/or acaricidal activity.
Compounds B-1 to B-88 are known in the art. For example, B-1, butyl [3- (2, 4-dichlorophenyl) -2-oxo-1-oxaspiro [4.5] dec-3-en-4-ylbutyl carbonate (CAS 1305319-70-3) is disclosed in CN 102060818 (2011). B-2, fluthrin (CAS 101007-06-1) is disclosed in US 4542142 (1985). B-3 fenazaquin (CAS 120928-09-8) is disclosed in EP 326329 (1989). B-5, N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl ] phenyl ] methyl ] cyclopropanecarboxamide (CAS 1365070-72-9) and B-6, (S) -N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl ] phenyl ] methyl ] cyclopropanecarboxamide (CAS 2044701-44-0) are disclosed in WO 2012035011. B-7,Fluxametamide (CAS 928783-29-3) is disclosed in WO 2007026965. B-8, spidoxaat (CAS 907187-07-9) is disclosed in WO 2006089633. B-9,x Bromoin fluorobenzamide (CAS 1207727-04-5) is disclosed in WO 2010018714. B-10, nicofluprolole (CAS 1771741-86-6) is disclosed in WO 2015067647. B-11, cyclopropanamide (CAS 2375110-88-4) is disclosed in WO 2020001067. B-12,5- [ [3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichloro-cyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide (chemical abstracts number 2220132-55-6), B-13,5- [ [ (1R, 3R) -3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichlorocyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide, and B-14,5- [ [ (1s, 3s) -3- [3, 5-bis (trifluoromethyl) phenyl ] -2, 2-dichloro-cyclopropanecarbonyl ] amino ] -2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino ] -2, 4-difluoro-phenyl ] benzamide, WO2018071327 is disclosed in WO 807180327. B-15, tetrachloro-insect benzamide (CAS 1104384-14-6) is disclosed in CN101333213 (2008). B-16,afidopyropen (CAS 915972-17-7) is disclosed in WO 2006129714. B-17, 4-dimethyl-2-2- (3-pyridyl) indazol-5-yl ] -1,2, 4-triazolidine-3, 5-dione (CAS 2171099-09-3) is disclosed in WO 2018011111. B-18,N-3-chloro-1- (3-pyridyl) pyrazol-4-yl ] -2-methylsulfonyl-propionamide (CAS 2396747-83-2) is disclosed in WO 2019236274. B-19,Tyclonazolor (CAS 1477919-27-9) is disclosed in WO 2013162715. B-20, N- (1-methylcyclopropyl) -2- (3-pyridyl) indazole-4-carboxamide (CAS 1689545-27-4) is disclosed in WO 2015038503. B-21, dimppyridazz (CAS 1403615-77-9) is disclosed in WO 2012143317. B-22, flonicamid (CAS 158062-67-0) is disclosed in EP 580374 (1994). B-23, pyrifluquinazon (CAS 337458-27-2) is disclosed in EP 1097932 (2001). B-24, pymetrozine (CAS 123312-89-0) is disclosed in EP 31461 (1989). B-25, fipronil (CAS 120068-37-3) is disclosed in EP 295117 (1988). B-26,3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (CAS 2413839-57-1), b-27, (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (CAS 2413390-32-4), B-28, (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (enolate tautomer) (CAS 2413839-58-2) and B-29, (3R) -3- (2-Chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ] pyrimidin-8-ium-7-ol (dione) (CAS 2246757-58-2) is disclosed in WO 2018177970. B-30, trifluorophenylpyrimidine (CAS 1263133-33-0) is disclosed in WO 2011017351. B-31,1- (2-cyanoethyl) -4-oxo-3- [3- (trifluoromethyl) phenyl ] pyrido [1,2-a ] pyrimidin-1-2-ium-2-ol salt (CAS 2032403-97-5) is disclosed in WO 2016171053. B-32, clopyralid (CAS 1263629-39-5) is disclosed in WO 2011017342. B-33, imidacloprid (CAS 138261-41-3) is disclosed in DE 3818163 (1989). B-34, fluopyranone (CAS 951659-40-8) is disclosed in DE 102006015467 (2007). B-35, thiacloprid (CAS 111988-49-9) is disclosed in EP 235725 (1987). B-36, sulfoxaflor (CAS 946578-00-3) is disclosed in WO 2007095229. B-37 acetamiprid (CAS 135410-20-7) is disclosed in JP 2001288004. B-38,Fluporyimin (CAS 1363400-41-2) is disclosed in WO 2012029672. B-39, dinotefuran (CAS 165252-70-0) is disclosed in EP 649845 (1995). B-40, nitenpyram (CAS 150824-47-8) is disclosed in EP 392560 (1990). B-41, clothianidin (CAS 210880-92-5) is disclosed in JP 2000247821 (2000). B-42, thiamethoxam (CAS 153719-23-4) is disclosed in EP 580553 (1994). B-43, tetrazoxamide (CAS 1229654-66-3) is disclosed in WO 2010069502. B-44, flubendiamide (CAS 272451-65-7) is disclosed in EP 1006107 (2000). B-45, chlorantraniliprole (CAS 500008-45-7) is disclosed in WO 2003015519. B-46, cyantraniliprole (CAS 736994-63-1) is disclosed in WO 2004067528. B-47, 5-bromo-2- (3-chloro-2-pyridinyl) -N- [4, 6-dichloro-3-fluoro-2- (methylcarbamoyl) phenyl ] pyrazole-3-carboxamide (CAS 2129147-03-9) is disclosed in CN 106977494 (2017). B-48, cyclic bromoamides (CAS 1031756-98-5) are disclosed in WO 2005077934. B-49, cyhalodiamide (CAS 1262605-53-7) is disclosed in CN 101935291 (2011). B-50, 5-bromo-2- (3-chloro-2-pyridyl) -N- [2, 4-dichloro-6- (isopropylcarbamoylthio) phenyl ] pyrazole-3-carboxamide (CAS 1442448-92-1) is disclosed in CN 103130770 (2013). B-51,1- [6- (2, 2-difluoro-7-methyl- [1,3] dioxolo [4,5-f ] benzimidazol-6-yl) -5-ethanesulfonyl-3-pyridinyl ] cyclopropanecarbonitrile (CAS 2408220-94-8) is disclosed in WO 2020013147. B-52,6- (5-cyclopropyl-3-ethanesulfonyl-2-pyridyl) -2, 2-difluoro-7-methyl- [1,3] dioxolo [4,5-f ] benzimidazole (CAS 2408220-91-5) is disclosed in WO 2020013147. B-53,2- (5-cyclopropyl-3-ethylsulfonyl-2-pyridyl) -5- (trifluoromethylsulfonyl) -1, 3-benzoxazole (CAS 2128706-05-6) is disclosed in WO 2017146226. B-54 and B55,2- [ 3-ethylsulfonyl-5- (trifluoromethyl) pyrazolo [1,5-a ] pyridin-2-yl ] -3-methyl-6- (trifluoromethyl) imidazo [4,5-B ] pyridine (CAS 2133042-44-9 and CAS 2133042-31-4) is disclosed in WO 2017155103. B-56,2- [ 3-ethylsulfonyl-6- (1, 2, 4-triazol-1-yl) -2-pyridyl ] -3-methyl-6- (trifluoromethyl) imidazo [4,5-B ] pyridine (CAS 1808115-49-2) is disclosed in WO 2015133603. B-57,2- (3-ethylsulfonyl-2-pyridyl) -5- (2,2,3,3,3-pentafluoropropyloxy) pyrazine (CAS 2095470-94-1) is disclosed in WO 2017065228. B-58,azolufyl (CAS 1616678-32-0) is disclosed in WO 2014104407. B-59, a benzopyrimidine (CAS 1449021-97-9) is disclosed in WO 2013115391. B-60, indoxacarb (CAS 173584-44-6) is disclosed in WO 9529171. B-61, metaflumizone (CAS 139968-49-3) is disclosed in EP 462456 (1991). B-62 deltamethrin (CAS 52918-63-5) is disclosed in DE 2439177 (1975). B-63 bifenthrin (CAS 82657-04-3) is disclosed in GB 2085005 (1982). B-64, gamma-cyhalothrin (CAS 76703-62-3) is disclosed in GB 2143823 (1985). B-65, beta-cypermethrin (CAS 1315501-18-8) is disclosed in WO 2008005764 (2008). B-66, alpha-cypermethrin (CAS 67375-30-8) is disclosed in JP 55164608 (1980). B-67, fenvalerate (CAS 51630-58-1) is disclosed in DE 2335347 (1974). B-68, cis-fenvalerate (CAS 66230-04-4) is disclosed in DE 2737297 (1978). B-69, lambda-cyhalothrin (CAS 91465-08-6) is disclosed in EP 106469 (1984). B-70, tefluthrin (CAS 79538-32-2) is disclosed in JP 55111445 (1980). B-71, (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 1445683-71-5), B-72, (R) - (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 2377084-09-6) and B-73,2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 1445684-82-1) are disclosed in WO 2013092350. B-74, flupentiofenox (CAS 1472050-04-6) is disclosed in WO 2013157229. B-75,Fluffeneim (CAS 170015-32-4) is disclosed in EP 665225. B-76,Fluhexafon (CAS 1097630-26-6) is disclosed in WO 2009005110. B-77 methoxyfenozide (CAS 161050-58-4) is disclosed in CA 2103110. B-78, tebufenozide (CAS 112410-23-8) is disclosed in JP 62167747 (1987). B-79 fluoparam (CAS 658066-35-4) is disclosed in EP 1389614 (2004). B-80, fluazaindolizine (CAS 1254304-22-7) is disclosed in WO 2010129500. B-81, guadipyr (CAS 1227849-60-6) is disclosed in WO 2010060231. B-82, pyridalyl (CAS 179101-81-6) is disclosed in WO 9611909. B-83,3, 4-trifluoro-3-butenyl-2- (2-methoxyphenyl) 5-oxo-tetrahydrofuran-3-carboxylate (CAS 2074661-82-6) is disclosed in CN 106342882 (2017). B-84,tioxazafen (CAS 330459-31-9) is disclosed in WO 2006114400. B-85, afoxonolaner (CAS 1093861-60-9) is disclosed in WO 2009002809. B-86, fluralane (CAS 864731-61-3) is disclosed in WO 2005085216. B-87, sarolaner (CAS 1398609-39-6) is disclosed in WO 2012120399. B-88,Tigolaner (CAS 1621436-41-6) is disclosed in WO 2014122083.
Pests to which the present invention relates include, but are not limited to, the following examples:
<xnotran> , (Acalitus spp.), (Aculus spp), (Acaricalus spp.), (Aceria spp.), (Acarus siro), (Amblyomma spp.), (Argas spp.), (Boophilus spp.), (Brevipalpus spp.), (Bryobia spp), (Calipitrimerus spp.), (Chorioptes spp.), (Dermanyssus gallinae), (Dermatophagoides spp), (Eotetranychus spp), (Eriophyes spp.), (Hemitarsonemus spp), (Hyalomma spp.), (Ixodes spp.), (Olygonychus spp), (Ornithodoros spp.), (Polyphagotarsone latus), (Panonychus spp.), (Phyllocoptruta oleivora), (Phytonemus spp.), (Polyphagotarsonemus spp), (Psoroptes spp.), (Rhipicephalus spp.), (Rhizoglyphus spp.), (Sarcoptes spp.), (Steneotarsonemus spp), (Tarsonemus spp.) (Tetranychus spp.); </xnotran>
From the order of the Anoplura, for example the genera Sauropus (Haematopinus spp.), pestalotidae (Linoganthus spp.), pediculus (Pediculus spp.), miyasu (Pemphigus spp.), and Peshilago (Phyllotre spp.)
<xnotran> , (Agriotes spp.), (Amphimallon majale), (Anomala orientalis), (Anthonomus spp.), (Aphodius spp), (Astylus atromaculatus), (Ataenius spp), (Atomaria linearis), (Chaetocnema tibialis), (Cerotoma spp), (Conoderus spp), (Cosmopolites spp.), (Cotinis nitida), (Curculio spp.), (Cyclocephala spp), (Dermestes spp.), (Diabrotica spp.), (Diloboderus abderus), (Epilachna spp.), eremnus spp., (Heteronychus arator), (Hypothenemus hampei), lagria vilosa, (Leptinotarsa decemLineata), (Lissorhoptrus spp.), liogenys spp, maecolaspis spp, (Maladera castanea), megascelis spp, melighetes aeneus, (Melolontha spp.), myochrous armatus, (Orycaephilus spp.), (Otiorhynchus spp.), (Phyllophaga spp), (Phlyctinus spp.), (Popillia spp.), (Psylliodes spp.), rhyssomatus aubtilis, (Rhizopertha spp.), (Scarabeidae), </xnotran> Rice weevil (Sitophilus spp.), hornworm (Sitotrogaga spp.), pseudorhizopus (Somaticus spp.), aphanidermatum (Sphenophorus spp.), soybean stem weevil (Sternechus subsignatus), walker (Tenebrio spp.), darkling (Tribolium spp.), and spotted bark beetle (Trooderma spp.);
is from the order of the Diptera, such as the genera Aedes (Aedes spp.), anopheles (Anopheles spp), sargassu (Anotherodon sorbita), sarcophaga (Anthericona sorbita), sarcophaga olivaceus (Bactrocera oleae), aedes hortorum (Bibio hortula), hizikia (Bradysia spp.), sarcophaga rubra (Callyphora erythropolis), sarcophaga (Ceratitis spp.), chrysomyelia (Chrysomyelia spp.), culex (Culex spp.), flas (Cuterebra spp.), agrostis (Dacus spp.), sarcophaga (Delia spp.), sarcophaga (Drosophila melanogaster), sarcophaga (Fabricius spp.), gastrophila (Gastrophania spp.), and Geotrichu (Germinula spp.). Pisca (Hypoderma spp.), pediculus (Hypmobosa spp.), hyppomosa (Hypmobosa spp.), musca (Liriomyza spp.), lucilia (Lucilia spp.), scirpus (Melanagermyza spp.), musca (Musca spp.), musca (Oestrus spp.), hyriopsis (Orseolia spp.), thankara (Oscenella frit), haynaud fly (Pegomyhyglomamia), phlebia (Phorbid spp.), tabanus (Rhagonotus spp.), rivelia drifera, scattera spp, scutella (Scenaria spp.), musca (Scira spp.), scena spp.);
<xnotran> , (Acanthocoris scabrator), , , (Amblypelta nitida), (Bathycoelia thalassina), , , clavigralla tomentosicollis, (Creontiades spp.), , dichelops furcatus, , edessa spp, (Euchistus spp.), (Eurydema pulchrum), , , (Horcias nobilellus), (Leptocorisa spp.), , , (Murgantia histrionic), (Neomegalotomus spp), (Nesidiocoris tenuis), , (Nysius simulans), (Oebalus insularis), , , , , (Scaptocoris castanea), (Scotinophara spp.), thyanta spp, , (Vatiga illudens); </xnotran> <xnotran> , adalges spp, agalliana ensigera, (Agonoscena targionii), (Aleurodicus spp.), (Aleurocanthus spp), , (Aleurothrixus floccosus), (Aleyrodes brassicae), (Amarasca biguttula), (Amritodus atkinson), , (Aonidiella auranti), , , (Aspidiotus spp.), , (Bactericera cockerelli), , (Brachycaudus spp), , , (Cavariella aegopodii Scop.), , , , (Cicadella spp), (Cofana spectra), , (Cicadulina spp), , , , , , , , , , , (Glycaspis brimblecombei), , (Hyalopterus spp), , (Idioscopus clypealis), (Jacobiasca lybica), , , , (Lopaphis erysimi), lyogenys maidis, , (Mahanarva spp), (Metcalfa pruinosa), , myndus crudus, , , , (Nilaparvata spp.), </xnotran> Greater green aphid of pear, sinapis dactylorum (Odonaspsis ruthae), miyaya parasitica, bemisia myrica, coccinum, scobius pellucida, agkistrodon sp, agkistrodon gall, corn Cercosphaera, pectinopus deltoides, aphis neglectum, rhizobium, planococcus spp, scobius albus, gecko, lygus lucorum (Pseudobulbus seriatus), carpesium, cotton scales (Pulvinaria aethiopica), tolyphaera, quesada gigas, odonia gigantea, odonia peltata, odonia viridans, odonia littora, odonia variola, odonia pelagi, odonia pelagitans, odonia litura, odonia sinensis, odonia pelagina, and Odonia pelagina electric leafhopper (Recilia dorsalis), sisinonova, erysipelothrix, pectinopus, diploptera, myzus (Sitobion spp.), white-backed planthopper, lucercus triangularis (Spissileus festinus), striped spotted planthopper (Tarophagus prosecutis), achnus, bemisia, tridiscus sporoooli, bellevium spp., african psyllid, arrowhead, irvingia fusca (Zygina flammigera), and Zyginidia sculus cutellaris;
from the order hymenoptera, for example, the genera acrophylla (Acromyrmex), trichogramma (Arge spp.), brevifolia (Atta spp.), stemona (cephalospora spp.), coniferae (Diprion spp.), cera serrulata (trichoderma spp.), cera serrulata (Diprion family), coniferae (Diprionidae), coniferae (Gilpinia polytoma), pyricularia (hoppleocampisp.), chaetophora (Lasius spp.), solenopsis (soleus spp.), solenopsis minutissima (monorions), neoconidia (neodriron spp.), agrimonia (pogomomy spp.), pyricularia (podomorph spp.), pyricularia (scrinopsis invincina), termitornus (Solenopsis spp.), and Vespa spp.);
from the order of the Isoptera, e.g., coptotermes spp, termite (Corniteneres cumulans), acanthotermes spp, macrotermes spp, macastermes spp, microtermes spp, reticulitermes spp; imported tropical fire ants (Solenopsis geminate);
<xnotran> , , , , , , amylois , , , (Argyresthia spp.), , , , , , , , , (Chrysote uchia topiaria), , , , , , , cosmophila flava, , , , , , , , , , , , (Epinotia spp), , etiella zinckinella, , , , , feltia jaculiferia, grapholita , , , , (Herpetogramma spp), , , lasmopalpus lignosellus, , , , loxostege bifidalis, , , , , , mythimna , , , orniodes indica, , , , , , pectinophora gossypi-ela, , , , , , , , , , (Richia albicosta), (Scirpophaga spp.), , , , , </xnotran> The genus Homoptera, isonavicula, heliothis, trichoplusia, liriomyza lycopersici, and Neplutella;
from the order of the mallophaga, for example, the genera louse and rodentia;
from the order orthoptera, such as the genera Periplaneta, gryllotalpa, blatta madder, locusta, gryllus chinensis (Neourilla hexadactyla), periplaneta, gryllus chinensis (Scapertiscus spp), and Acridium desert;
from the order rodentia, e.g. the genus cisselis spp;
from the order Siphonaptera, for example, siphonaptera (Ceratophyllus spp.), ctenocephalides (Ctenocephalides spp.), and Xenopsylla cheopis (Xenopsylla cheopis);
from the order of the Thysanoptera, such as Calliothrips phaseoli, frankliniella spp, silybum spp (Heliothrips spp), frankliniella spp (Hercinothrips spp.), silybum spp (Parthenothrips spp.), cirsium spp (Parthenothrips spp.), nereid-Hethistle (Scoththrips aurantii), thrips sojae (Sericothrips variabilis), thrips spp (Taeniothiopsis spp.), and Thrips spp (Thrips spp.);
from the order of the Thysanoptera, for example, lepisma saccharina (Lepisma saccharana).
In another aspect, the invention also relates to a method of controlling damage to plants and parts thereof by plant-parasitic nematodes (endoparasitic, hemiendoparasitic and ectoparasitic nematodes), in particular plant-parasitic nematodes such as root-knot nematodes (root knot nematodes), northern root-knot nematodes (Meloidogyne hapla), southern root-knot nematodes (Meloidogyne incognita), java root-knot nematodes (Meloidogyne javanica), floral root-knot nematodes (Meloidogyne arenaria) and other species of Meloidogyne species (Meloidogyne species); cyst-forming nematodes (cyst-forming nematodes), potato nematodes (Globodera rostochiensis) and other coccidioidomycosis species (Globodera species); heterodera avenae (Heterodera avenae), heterodera glycines (Heterodera glycines), heterodera betanae (Heterodera schachtii), heterodera erythraea (Heterodera trifolii), and other Heterodera species (Heterodera species); seed gall nematodes (Seed grain nematodes), granulomatous species (Anguina species); stem and foliar nematodes (Stem and leaf nematodes), aphelenchoides species (Aphelenchoides species); nematodiasis (stinging nematodies), nematodiasis longus (elenoloimus longicaudatus) and other nematodiasis species (Belonolaimus species); pine nematodes (Pine nematodes), pine wood nematodes (Bursaphelenchus xylophilus) and other Umbelliferae species (Bursaphelenchus species); roundworm (Ringnematodas), cyclonematode species (Criconema species), cyclonematode species (Criconemoidea species), mesociconema species (Mesociconema species); stem and bulb nematodes (Stem and bulb nematodes), rot Stem nematodes (Ditylenchus destructor), bulb nematodes (Ditylenchus dipsci) and other phyla species (Ditylenchus species); conus nematodes (Awl nematodes), conus species (Dolichodorus species); helicoptera (Spiral nematodes), helicoptera multicephala (helicocortices multicinctus) and other species of the genus helicoptera (Helicotylenchus species); sheath and Sheath nematodes (Sheath and sheathoid nematodes), coleptonematode species (Hemicyophora species), and hemicycle nematode species (Hemicomoneoides species); the species Meloidogyne spp (Hirshmanniella species); branch nematodes (lancet nematodies), coronarium species (hoplaeimus species); pseudoroot knot nematodes (false rootknot nematodes), phyllanthus species (Nacobbus species); acicular nematodes (Needle nematodes), longilineans (longidrus elongatus) and other longtylenchus species (longidrus species); pin nematodes (Pin nematodes), pratylenchus species (Pratylenchus species); pythium aphrodisiae (nematodes), pratylenchus negectis (Pratylenchus negectius), pratylenchus penetrans (Pratylenchus penetans), pratylenchus curvatus (Pratylenchus curvatus), pratylenchus guli (Pratylenchus goodyyi), and other Pratylenchus species (Pratylenchus species); citrus piercing nematodes (Burrowing nematodes), banana piercing nematodes (Radopholus simiis) and other endoparasitic species (Radopholus species); reniform nematodes (Reniform nematodies), rotifers' helicoptera (Rotylenchus robustus), reniform gyrus (Rotylenchus reniformis) and other species of gyrus (Rotylenchus species); the species of the genus Scutellaria (Scutellonema species); nematodes (Stubby root nematodes), primitive ragworms (tricholorus priviivus), and other species of burred nematodes (tricholorus species), pseudoburred nematodes (parterrichorus species); dwarf nematodes (Stunt nematodes), portulaca dwarfis (Tylenochlornchus clavoni), cis-trans dwarfing nematodes (Tylenochlornchus dubius) and other species of dwarfing nematodes (Tylenochlornchus species); citrus nematodes (Citrus nematodes), piercing nematode species (Tylenchulus species); nematodes (Dagger nematates), sisalanobis species (xiphilima species); and other plant parasitic nematode species such as, for example, subglobium spp, meloidogyne spp, megastronghomia spp, strongyloides, dwarfed nematode mellinius spp, punctuated cyst spp, and quinsulius spp.
The combinations and compositions of the invention may also have activity against molluscs. Examples of such molluscs include, for example, the spiroid family (Ampullaridae); arrowia (Arion) (Arrowia griseoae (A. Ater), arrowia giraldii (A. Circumscript), arrowia couragea (A. Terrens), and Arrowia palmata (A. Rufus)); babacaidae (bradbaenidae) (bradbaena fructicum)); snails (Cepaea) (yard snail (c. Hortens), forest snail (c. Nemoralis)); ochlodina; gray slug genera (Deroceras) (wild gray slugs (d. Agrestis), d. Empiricorum, field gray slugs (d. Laeve), yard gray slugs (d. Particulate)); discos (discoid) (d.rotundatus); euomphalia; cochlear (Galba) (truncated cochlear (g.))); small snails (hellicelia) (eata snails (h.itala), buwei snail (h.obvia)); the family of the giant snailaceae (helicoidae) heliconia arbustorum); helicodis; snail (Helix) (open big snail (h. Aperta)); slug genera (Limax) (ash black slugs (l.ringoniger), yellow slugs (l.flavus), marginal slugs (l.marginatus), large slugs (l.maxima), soft slugs (l.tenellus)); lymnaea (Lymnaea); milax (greenhouse slug) (m.gagates, m.marginatus, m.sowerbyi); genus treponema (Opeas); oncomelania (pomocea) (canaliculata); the genera Melandrium (Vallonia) and Anaestheta (Zanitioides).
The compositions according to the invention can be used for controlling pests of the type mentioned above, which pests preferably occur on plants, in particular on plants and ornamentals useful in agriculture, horticulture and forestry, or on tissue organs of these plants, such as fruits, flowers, leaves, stems, tubers or roots, and in some cases remain protected against these pests even on plant organs which are formed later.
Particularly suitable crops are, in particular, cereals, such as wheat, barley, rye, oats, rice, maize or sorghum fruits, for example pomes, stone or soft fruits, such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberry, raspberry or blackberry mustard, olives, sunflowers, coconuts, castor-oil plants, cocoa or ground nuts such as cotton, flax, hemp or jute asparagus, cabbage, carrots, onion, tomatoes, potatoes or sweet pepper nuts, coffee, eggplants, sugar cane, tea, peppers, vines, hops, plantainaceae and latex plants.
The compositions of the present invention may also be used on any ornamental and/or vegetable crop, including flowers, shrubs, broad-leaved trees and evergreens.
For example, the present invention may be used in any of the following ornamental species, but is not limited to: ageratum spp, alonsou (Alonsoa spp.), anemone (Anemone spp.), anisodamine, chamomile, goldenrod, aster and begonia. (e.g. B.Elatior, B.Semperflores, B.Tubreux), gekko gecko (Bougainavillea spp.), theobroma (Brachynome spp.), eupatorium (ornamental), typhae flower, capsicum annuum, catharanthus roseus, calliana, centaurea procumbens, chrysanthemum (C.maritime), chrysanthemum (Coreopsis spp.), rhodiola rosea (Crulaca cocinina), dahlia (Cuphea ignea), dahlia (Dahlia spp.), chlorophytum (Dicentra spectabilis), myrtle (Doratula spp.), eustoma grandiflorum (Eustoloniferula, forsythia spp.), helianthus rubrum (Gomphrena globosa, helichrysum spp.), rhododendron (Helichrysum spp.), hippo (Helichia spp.), hippo spp.), hibiscus (Helichia spp.), hibiscus spp.), kalancholla spp.), kalanchoma spp., helichia spp.), kasanura spp. Lavatera trimestris, leonotis Leonerus, lilium (Lilium spp.), anoectochilus roxburghii (Nemesia spp.), tagetes erecta (Tagetes spp.), dianthus chinensis spp., carcinia Maultflora champ, canna, oxalium, pelargonium graveolens, dioscorea peltata (P.Zonale), viola (Viola spp., viola tricolor, petunia, folum, camellia, poinsettia, tinospora (Euphorbia pentandra, euphorbia trilobata), primula (Primula spp.), ranunculus (Ranunculus spp.), dudu (Rhododendron spp., rose, rucoreca, sapodia spp., intpaulia spp., salivaa, rhodiola saaeda spp., schizophylla stoseula spp., sal, rhodiola sayta spodopsis, salicornia spp.
For example, the invention may be used in any of the following plant species but is not limited to: allium plants (a.sativum, a.cepa, a.oschaninii, a.porrum, a.ashalocum, a.fistulosum), anthriscus sylvestris (Anthriscus cerefolium), celery (Apium graveolus), asparagus (Asparagus officinalis), beet (Beta vulgaris vulgarus), brassica (Brassica spp.), cabbage, beijing chicory (b.rapa), capsicum (Capsicum annuum), chickpea (Cicer arietinum), chicory (cichorinemia), cichorium intybus (Cichorium spp.), endosvia, citrobacter (Citrillus lanatus), cucumis (Cucumis spp.), c.sativus, c.melolus, c.melolo, cucurbita (Cucurbita spp.), c.pepo, c.maxima, cyanobacteria (Cyanara spp.), c.scolymus, c.carduulus, carrot (Daucus carota), fennel (Foeniculum vulgare), hypericum (euphorbia spp.), l.esceucutium, l.lycopersicum, mentha (Mentha spp.), basil (Ocimum basilicum), parsley (Petroselinum crispum), kidney bean (Phaseolus spp.), p.vulgares, p.coccineus, pea, radish, sage, rosemary, and the like; scorzonera hispanica, solanum melogana, spinacea, valeriananella spp.
Preferred ornamental species include african violet, begonia, dahlia, gerbera, hydrangea, verbena, rose, kalanchoe, poinsettia, aster, cornflower, chamomile, delphinium, unipetalum, prosapocarpus, rhodiola, sedum, petunia, viola, balsamine, geranium, chrysanthemum, ranunculus, crimson, sage, wild aucklandia, rosemary, sage, saint johnswort, mint, sweet pepper, tomato, and cucumber.
The combinations and compositions of the invention are particularly useful for controlling
Pests of the order Hemiptera, e.g. one or more of Bemisia tabaci, aphis fabae, myzus persicae, aphis graminicola, nilaparvata and Orgus plant (preferably in vegetables, soya and sugar cane)
Lepidoptera pests, such as one or more of Spodoptera littoralis (Spodoptera littoralis), spodoptera frugiperda (Spodoptera frugiperda), plutella xylostella (Plutella xylostella), cnaphalocrocis medinalis (Cnaphalocrocis medinalis), codling moth (Cydia pomonella), arthrobotrys agnus (Chrysodynia insipidus), chilo suppressalis, diatraea grandiflora (Elasmopalpus lignosella), spodoptera somnifera (Pseudoplusia inclusians) and Lycopersicon esculentum (Tuta abscolus) (preferably in rice, vegetables and maize)
Pests of the order Thysanoptera (Thysanoptera), e.g. thrips (Thripidae), e.g. one or more of cynara scolymus and circium occidentalis (preferably in vegetables)
Soil pests (e.g. coleoptera), for example: striped beetles (Diabrotica balteata), golden beetles (Agriotes spp) and potato beetles (leptinotara decemlineata) (preferably in vegetables and corn).
Reference herein to "crops" is to be understood as also including transgenic plants which are capable of synthesising one or more selectively acting toxins, for example from toxin-producing bacteria, particularly those of the genus bacillus and the like, by the use of recombinant DNA techniques.
Such transgenic plant expressed toxins include, for example, insecticidal proteins, such as insecticidal proteins from bacillus cereus or bacillus japonicus, e.g., delta-endotoxins. For example Cry1Ab, cry1Ac, cry1F, cry1Fa2, cry2Ab, ccry3A, ccry3BB1 or Cry9C, or a plant insecticidal protein (VIP), for example VIP1, VIP2, VIP3 or VIP3A, such as photobacterium, xenorhabdus nematophilus wasp toxin and other insect-specific neurotoxins barley lectins or snowflake lectin melon protease inhibitors, such as ricin, zein, abrin, lupin, adenophora or brookfield protein ecdysteroid-UDP-glycosyltransferase, cholesterol oxidase, ecdysone inhibitors, HMG-CoA-reductase, ion channel blockers, such as sodium or calcium channel blockers, juvenile hormone esterase, diuretic hormone receptor, stilbene synthase, bibenzyl synthase chitinase and glucanase.
The delta-endotoxins described herein are understood to include, but are not limited to, e.g., cry1Ab, cry1Ac, cry1F, cry1Fa2, cry2Ab, cy 3 ACCy 3Bb1 or Cry9c, or Vegetative Insecticidal Proteins (VIP) such as VIP1, VIP2, VIP3 or VIP3A, particularly hybrid, truncated, and modified toxins. Hybrid toxins are recombinantly produced by a new combination of the different domains of these proteins (see, e.g., WO 02/15701). Truncated toxins, such as truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are substituted. In such amino acid substitutions, it is preferred to insert a non-naturally occurring protease recognition sequence into the toxin, for example, in the case of Cry3A055, a cathepsin-G-recognition sequence into the Cry3A toxin (see WO 03/018810).
Examples of such toxins or transgenic plants capable of synthesizing such toxins are disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073.
Methods for the production of such transgenic plants are generally known to the person skilled in the art and are described in the publications mentioned in the examples. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95/34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651.
The toxin contained in the transgenic plant confers tolerance to harmful insects to the plant. Such insects may occur in any of the classified insect groups, but are particularly common in beetles (coleoptera), diptera (diptera) and moths (lepidoptera).
Transgenic plants are known to contain one or more genes encoding insecticidal resistance and expressing one or more toxins, and most products are on the market. Examples of such plants are YieldGard Symbol 210 \/f Symbol "\/s 11 (Cry 1Ab toxin expressing maize variety) YieldGard Rootwork Symbol 210 \/f 'Symbol s 11 (Cry 3Bb1 toxin expressing maize variety) YieldGard Plus Symbol 210/f' Symbol" \/s 11 (Cry 3Bb1 toxin expressing maize variety) Star ink Symbol 210 f Symbol "\/s 11 (Cry 9C toxin expressing maize variety) Herculex I Symbol f Symbol s 11 (Cry 1Fa2 toxin and phosphinothricin N-acetyltransferase (PAT) expressing maize variety) and COmbol 33B achieving tolerance to herbicide tolerance to Bombol I Symbol I Symbol S11 (Cry 1Fa2 toxin and phosphinothricin N-acetyltransferase (PAT) expressing Cry 210. Lamymboll s 11) to the herbicide tolerance to Bombol I Symbol
(Cotton varieties expressing Cry1Ac and Cry2Ab toxins) VIPCOT SYMBOL 210\ "F" SYMBOL S11 (cotton varieties expressing VIP3A and Cry1Ab toxins) NewLeaf Symbol 210\ "f" Symbol S11 (potato varieties expressing Cry3A toxins) Nature Gard Symbol 210\ "f" Symbol S11,
GT Advantage (GA 21 glyphosate tolerance trait),
CB Advantage (BT 11 Corn Borer (CB)) characteristic) and Protecta.
Examples of such transgenic crops include, but are not limited to:
BT11 maize, from Syngenta Seeds SAS, chemin de l Hobit 27, F-31 St. Sauveur, france, registration number C/FR/96/05/10. Transgenic maize is resistant to attack by Ostrinia nubilalis and sesami nonagrioides by transgenic expression of a truncated Cry1Ab toxin. BT11 maize also transgenically expresses the PAT enzyme to achieve tolerance to the herbicide glufosinate.
BT176 maize, from Syngenta Seeds SAS, chemin de l Hobit 27, F-31 790 St. Sauveur, france, registration number C/FR/96/05/10. Transgenic maize that is rendered resistant to attack by european corn borers (Ostrinia nubilalis and sesami nonagrioides) by transgenic expression of Cry1Ab toxin. Bt176 maize also transgenically expresses the PAT enzyme to achieve tolerance to the herbicide glufosinate-ammonium.
3. MIR604 maize from Syngenta Seeds SAS, chemin de l Hobit 27, F-31 790 St. Sauveur, france, registration number C/FR/96/05/10. Maize that is rendered insect resistant by transgenic expression of the modified Cry3A toxin. The toxin is Cry3a055 modified by insertion of a cathepsin-G-protease recognition sequence. The production of such transgenic maize plants is described in WO 03/018810.
MON 863 corn, available from Monsanto Europe S.A.270-272 Avenue DE Tervuren, B-1150 Brussels, belgium, registration number C/DE/02/9.MON 863 expresses Cry3Bb1 toxin, which is resistant to certain coleopteran insects.
5. IPC 531 Cotton from Monsanto Europe S.A.270-272 Avenue de Tervuren, B-1150 Brussels, belgium, accession number C/ES/96/02.
6.1507 maize was from Pioneer overseas company, address Brussels 7B-1160 Tedesco Avenue, belgium, registration number C/NL/00/10. Transgenic maize for expressing the protein Cry1F to obtain resistance to certain lepidopteran insects and the PAT protein to obtain tolerance to the herbicide glufosinate.
NK603 XMON 810 maize, from Monsanto Europe S.A.270-272 Avenue de Tervuren, B1150 Brussels, belgium, accession number C/GB/02/M3/03.Consists of a conventional hybrid corn variety which is formed by hybridizing a transgenic variety NK603 and MON 810. NK603 × MON810 maize transgene expresses the protein CP4 EPSPS obtained from agrobacterium. Strain CP4 with weed-removing agent
Tolerance (with glyphosate) and Cry1Ab toxin obtained from Bacillus thuringiensis subspecies. Kurstaki is tolerant to certain lepidopteran insects including european corn borer.
Transgenic crops of insect-resistant plants are also described in BATS (Zentrum fur Bioscherheunit Nachhattgeitkeit, zentrum BATS, clarastrasse 13, 4058 Basel, switzerland) report 2003 (http:// BATS. Ch.).
"crops" are to be understood as also including crop plants which have been so transformed by using recombinant DNA techniques and which are capable of synthesizing pathogen-resistant substances having a selective action, for example the so-called "disease-related proteins" (PRPs, see for example EP-A-0 392 225). Examples of such anti-pathogenic substances and transgenic plants capable of synthesizing such anti-pathogenic substances are known, for example, from EP-A-0 392225, WO 95/33818 and EP-A-0 353 191. Methods for producing such transgenic plants are generally known to the person skilled in the art, as described in the above-mentioned publications.
"crop" may also be a crop modified to enhance resistance to fungal (e.g., fusarium, anthracnose, or phytophthora), bacterial (e.g., pseudomonas), or viral (e.g., potato leafroll virus, tomato spotted wilt virus, cucumber mosaic virus) pathogens.
"crops" also include those crops having increased resistance to nematodes, such as crop varieties resistant to soybean cyst nematodes.
Crops that are tolerant to abiotic stress include those that have enhanced tolerance to drought, high salt, high temperature, cold, frost or light radiation, for example, by expressing NF-YB or other proteins known in the art.
Such transgenic plant-expressed antipathogenic substances include, for example, ion channel blockers, blockers of the sodium and calcium channels, viruses KP1, KP4 or KP6 (toxin glucanases such as EP-A-0 392225) (described in WO 95/33818) or protein or polypeptide factors involved in the defense of plant pathogens (so-called "plant resistance genes", as described in WO 03/000906)
Further areas of use of the compositions according to the invention are the protection of stored goods and storage rooms and of raw materials, such as wood, textiles, floor coverings or buildings, and in the hygiene sector, in particular the protection of humans, domestic animals and productive livestock against the abovementioned pests.
The present invention provides a method of increasing the tolerance of a plant to abiotic stress, wherein the method comprises applying to the plant, plant tissue, plant propagation material or the habitat thereof a composition as described herein.
The present invention provides a method for regulating or improving the growth of a plant, wherein the method comprises applying to the plant, plant tissue, plant propagation material or the habitat a composition as described herein. In certain embodiments, the growth of a plant is modulated or improved when the plant is subjected to abiotic stress conditions.
By "regulating or improving the growth of a crop" is meant an improvement in the vigour of the plant, an improvement in the quality of the plant, an improvement in tolerance to stress factors and/or an improvement in the efficiency of input utilization.
By "plant" is meant all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, branches, leaves, and fruits.
The term "locus" as used herein refers to a field in or on which plants are grown, or on which seeds of cultivated plants are sown, or in which seeds are placed in the soil. It includes soil, seeds and seedlings, as well as established vegetation.
The term "plant propagation material" denotes all reproductive parts of a plant, for example seeds or vegetative parts of a plant, such as cuttings and tubers. It includes seeds in the strict sense, as well as roots, fruits, tubers, bulbs, rhizomes and parts of plants.
When a numerical range is disclosed herein (e.g., 1 to 10), this is intended to include all numbers and intermediate values within the range (e.g., 1, 1.1, 2,3, 3.9, 4,5, 6, 6.5, 7, 8, 9, and 10) and any sub-ranges of numbers and intermediate values within the range (e.g., 2 to 8, 1.5 to 5.5, and 3.1 to 4.7). Further, both the specified upper and lower limits are included in this range.
When a range or value is used herein before the term "about" is used, the term is intended to provide support for the exact number before it and a number near or approximate to it. In determining whether a number is near or approximately the specifically recited number, the near or approximate number may be a number that will be rounded to or substantially equal to the specifically recited number. For example, the term "about 5" includes 5.0, 4.5, 5.4, 4.92, 5.01, and the like.
The composition may be in the form of a concentrate, which is diluted prior to use, although ready-to-use compositions may also be prepared. The final dilution is usually performed with water, but may be performed with, for example, liquid fertilizers, micronutrients, biological organisms, oils or solvents instead of or in addition to water.
The compositions of the present invention are generally formulated in various ways using formulation aids such as carriers, solvents and surface active substances. The formulations may be in various physical forms, such as polymer films impregnated with powders, gels, wettable powders, water dispersible granules, water dispersible tablets, effervescent pellets, emulsifiable concentrates, micro-emulsifiable concentrates, oil-in-water emulsions, oil flowable, aqueous dispersions, oily dispersions, suspoemulsions, capsule suspensions, emulsifiable granules, soluble liquids, water soluble concentrates (with water or water miscible organic solvents as the carrier) or other known forms, such as from the manuals of formulation and use of the agro-pharmaceutical specifications of the grain and defense organizations, united nations, first edition, second edition (2010). Such formulations may be used as is or diluted prior to use. For example, dilution may be performed with water, liquid fertilizer, micronutrients, biological organisms, oil, or solvents.
The formulations may be prepared by mixing the active ingredient with formulation auxiliaries to obtain compositions in the form of finely divided solids, particles, solutions, dispersions or emulsions. The active ingredients can also be formulated with other adjuvants such as finely divided solids, mineral oils, oils of vegetable or animal origin, modified oils of vegetable or animal origin, organic solvents, water, surface-active substances or combinations thereof.
The active ingredient may also be contained in very fine microcapsules. Microcapsules contain the active ingredient in a porous carrier. This enables the active ingredient to be released into the environment in controlled amounts (e.g. sustained release). The microcapsules typically have a diameter of 0.1 to 500 microns. They contain the active ingredient in an amount of about 25-95% by weight of the capsule weight. The active ingredient may be in the form of a monolithic solid, in the form of fine particles in a solid or liquid dispersion or in the form of a suitable solution. The encapsulating film may comprise, for example, natural or synthetic rubbers, cellulose, styrene/butadiene copolymers, polyacrylonitrile polyacrylates, polyesters, polyamides, polyurea polyurethanes or chemically modified polymers and starch xanthates or other polymers known to the person skilled in the art. Alternatively, very fine microcapsules may be formed in which the active ingredient is contained in the form of finely divided particles in a solid matrix of matrix S, but the microcapsules themselves are not encapsulated.
Formulation auxiliaries suitable for preparing the compositions according to the invention are known per se. <xnotran> , : , , , , , , , , , , ,2- , , , , , , ,1,2- , , , , , , , , N, N- , ,1,4- , , , , , , ,2- , ,1,1,1- ,2- , α - , D- , , , , , γ - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , </xnotran> Paraffin wax, mineral oil, trichloroethylene, tetrachloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol, and higher molecular weight alcohols such as pentanol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol glycerol, N-methyl-2-pyrrolidone, and the like.
Suitable solid carriers are, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, diatomaceous earth, limestone, calcium carbonate, bentonite, calcium montmorillonite, cottonseed hulls, wheat flour, soybean flour, pumice, wood flour, ground walnut hulls, lignin, and the like.
Large amounts of surface-active substances can be used advantageously in solid and liquid formulations, in particular in those which can be diluted with a carrier before use. Surface-active substances can be anionic, cationic, nonionic or polymeric and they can be used as emulsifying, wetting or suspending agents or for other purposes. Typical surface-active substances include, for example, alkyl sulfates, such as diethanolammonium lauryl sulfate;
alkyl aryl sulfonates such as calcium dodecylbenzenesulfonate;
alkylphenol/alkylene oxide addition products, such as nonylphenol ethoxylate;
alcohol/alkylene oxide addition products, such as tridecyl alcohol ethoxylate;
soaps, such as sodium stearate;
alkyl naphthalene sulfonates such as sodium dibutylnaphthalene sulfonate;
dialkyl esters of sulfosuccinates, such as sodium bis (2-ethylhexyl) sulfosuccinate;
sorbitol esters, such as sorbitol oleate;
quaternary amines, such as lauryl trimethyl ammonium chloride, polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate;
block copolymers of ethylene oxide and propylene oxide;
and salts of monoalkyl and dialkyl phosphates;
and others as described, for example, in McCutcheons Detergents and Emulsifiers Annual, MC Publishing Corp., ridgewood New Jersey (1981).
Other adjuvants that may be used in the pesticide formulation include crystallization inhibitors, viscosity modifiers, suspending agents, dye antioxidants, foaming agents, light absorbers, mixing aids, defoamers, complexing or pH adjusting substances and buffers, corrosion inhibitors, fragrances, wetting agents, absorption promoters, micronutrient plasticizers, glidants, lubricants, dispersants, thickeners, antifreeze, bactericides, and liquid and solid fertilizers.
The compositions according to the invention may comprise oils of vegetable or animal origin, mineral oils, alkyl esters of these oils or mixtures of these oils and oil derivatives. The amount of oil additive in the compositions according to the invention is generally from 0.01 to 10%, based on the mixture to be applied. For example, after the spray mixture is prepared, the oil additive may be added to the spray tank at a desired concentration. Preferred oil additives include mineral oils or oils of vegetable origin, such as rapeseed oil, olive oil or sunflower oil, emulsified vegetable oils, alkyl esters of oils of vegetable origin, such as methyl derivatives, or oils of animal origin, such as fish oils or beef oils. Preferred oil additives include alkyl esters of C8-C22 fatty acids, in particular methyl derivatives of C12-C18 fatty acids, such as the methyl esters of lauric, palmitic and oleic acids (methyl laurate, methyl palmitate and methyl oleate, respectively.) a number of oil derivatives are known from the compendium of herbicide adjuvants (10 th edition, university of southern illinois 2010).
The compositions according to the invention generally comprise from 0.1 to 99% by weight, in particular from 0.1 to 95% by weight, of active ingredient and from 1 to 99.9% by weight of formulation auxiliaries, preferably comprising from 0 to 25% by weight of surface-active substances. While commercial products may preferably be formulated as concentrates, end users typically use dilute formulations.
The amount applied varies widely and depends on the nature of the soil, the method of application, the crop, the pests to be controlled, the prevailing climatic conditions and other factors controlled by the method of application, the time of application and the target crop. As a general guideline, the active ingredients may be applied at a rate of from 1 to 2000g/ha, especially from 10 to 1000 g/ha.
In certain embodiments, component (A) is applied in an amount of 20 to 200g/ha. In some examples, the application rate of component (a) is from 50 to 150g/ha, optionally from 50 to 70g/ha or about 100g/ha.
In certain embodiments, component (B) is applied in an amount of 20 to 200g/ha.
Preferred formulations may have the following composition (in weight%):
missible oil:
1-95%, preferably 60-90% of active ingredients;
1-30% of surfactant, preferably 5-20%;
1-80% of liquid carrier, preferably 1-35%;
powder preparation:
0.1-10% of active ingredients, preferably 0.1-5%;
solid carrier 99.9 to 90%, preferably 99.9 to 99%;
suspending agent:
5-75%, preferably 10-50% of active ingredients;
94-24% of water, preferably 88-30%;
1-40% of surfactant, preferably 2-30%;
wettable powder:
0.5-90%, preferably 1-80% of active ingredient;
0.5-20% of surfactant, preferably 1-15%;
5-95% of solid carrier, preferably 15-90%;
granules:
0.1-30% of active ingredient, preferably 0.1-15%;
99.5 to 70 percent of solid carrier, preferably 97 to 85 percent;
the following examples further illustrate the invention without limiting it.
| Wettable powder | a) | B) | C) |
| Active ingredient | 25％ | 50％ | 75％ |
| Lignosulfonic acid sodium salt | 5％ | 5％ | - |
| Sodium dodecyl sulfate | 3％ | - | 5％ |
| Di (isobutyl) naphthalene sulfonic acid sodium salt | - | 6％ | 10％ |
| Phenol polyethylene glycol ether | - | 2％ | - |
| (7-8 mol ethylene oxide) | |||
| Highly dispersed silicic acid | 5％ | 10％ | 10％ |
| Kaolin clay | 62％ | 27％ | - |
The composition is mixed well with the auxiliaries and the mixture is ground well in a suitable mill to give a wettable powder which can be diluted with water to give a suspension of the desired concentration.
| Powder for dry seed treatment | a) | B) | C) |
| Active ingredient | 25％ | 50％ | 75％ |
| Light mineral oil | 5％ | 5％ | 5％ |
| Highly dispersed silicic acid | 5％ | 5％ | - |
| Kaolin clay | 65％ | 40％ | - |
| Talc | - | 20 |
The composition is thoroughly mixed with the adjuvant and the mixture is thoroughly ground in a suitable grinder to give a powder which can be used directly for seed treatment.
| Emulsifiable concentrate | |
| Active ingredient | 10％ |
| Octyl phenol polyglycol ether | 3％ |
| (4-5 mol ethylene oxide) | |
| Calcium dodecyl benzene sulfonate | 3％ |
| Castor oil polyglycol ether (35 mol ethylene oxide) | 4％ |
| Cyclohexanone | 30％ |
| Xylene mixture | 50％ |
Any desired diluted emulsion which can be used for plant protection can be obtained from this concentrate by dilution with water.
| Powder preparation | a) | B) | C) |
| Active ingredient | 5％ | 6％ | 4％ |
| Talc | 95％ | - | - |
| Kaolin clay | - | 94％ | - |
| Mineral fillers | - | - | 96％ |
A ready-to-use powder is obtained by mixing the composition with a carrier and milling the mixture in a suitable mill. This powder can also be used for dry dressing of seeds.
| Granules | |
| Active ingredient | 15％ |
| Lignosulfonic acid sodium salt | 2％ |
| Carboxymethyl cellulose | 1％ |
| Kaolin clay | 82％ |
The composition is mixed with the adjuvant, ground and the mixture is moistened with water. The mixture was extruded and then dried in a stream of air.
| Coated particles | |
| Active ingredient | 8％ |
| Polyethylene glycol (molecular weight 200) | 3％ |
| Kaolin clay | 89％ |
In the mixer, the finely ground composition was applied uniformly onto the kaolin wetted with polyethylene glycol. In this way dust-free coated granules are obtained.
| Suspending agent | |
| Active ingredient | 40％ |
| Propylene glycol | 10％ |
| Nonyl phenol polyethylene glycol ether (15 mol ethylene oxide) | 6％ |
| Lignosulfonic acid sodium salt | 10％ |
| Carboxymethyl cellulose | 1％ |
| Silicone oils (in the form of a 75% aqueous emulsion) | 1％ |
| Water (W) | 32％ |
The finely ground combination is thoroughly mixed with the auxiliaries to give a suspension concentrate from which any desired diluted suspension can be obtained by dilution with water. With such dilutions, living plants and plant propagation material can be treated and protected against infestation by microorganisms by spraying, pouring or immersion.
| Flowable concentrate for seed treatment | |
| Active ingredient | 40％ |
| Propylene glycol | 5％ |
| Copolymerized butanol Po/EO | 2％ |
| Triphenylethylene phenols with 10-20 moles EO | 2％ |
| 1, 2-benzisothiazolesLin-3-one (in the form of a 20% aqueous solution) | 0.5％ |
| Calcium salts of monoazo pigments | 5％ |
| Silicone oils (in the form of a 75% aqueous emulsion) | 0.2％ |
| Water (I) | 45.3％ |
The finely ground combination is thoroughly mixed with the auxiliaries to give a suspension concentrate from which any desired diluted suspension can be obtained by dilution with water. With such dilutions, living plants and plant propagation material can be treated and protected against infestation by microorganisms by spraying, pouring or immersion.
Sustained release capsule suspension
28 parts of this combination are mixed with 2 parts of an aromatic solvent and 7 parts of a toluene diisocyanate/polymethylene-polyphenyl isocyanate mixture RE (8).. 6 parts of water until the desired particle size is reached. To this emulsion was added 2.8 parts of 1, 6-diaminohexane at 5. 3 parts of water are added. The mixture was stirred until the polymerization reaction was complete. The obtained capsule suspension was stabilized by adding 0.25 parts of thickener and 3 parts of dispersant. The capsule suspension formulation contained 28% active ingredient. The diameter of the middle capsule is 8-15 microns. The resulting formulation is applied to seeds in the form of an aqueous suspension in equipment suitable for this purpose.
The combination or composition of the invention may be applied to a plant, part of a plant, plant organ, plant propagation material or plant growing locus. Application is usually carried out by spraying (a) and (B) separately (i.e. in combination) or together (a) and (B) (i.e. composition), usually by a knapsack sprayer or a sprayer mounted on a tractor, but other methods such as dusting (for powders), drip application or drench application may also be used. Alternatively, the combination or composition may be applied in furrow or directly onto the seed prior to or at the time of planting.
The combinations or compositions of the present invention may be applied pre-emergence or post-emergence. When the combination or composition is used to modulate the growth of crop plants or to enhance tolerance to abiotic stress, it may be applied post-emergence of the crop. When the combination or composition is used to inhibit or delay seed germination, it may be applied pre-emergence. When the combination or composition is used to control pests, it can be applied as a prophylactic agent (before the pests are harmed). Or therapeutic (after pest damage) treatment.
The present invention contemplates applying the combinations and compositions of the present invention to plant propagation material, or any combination of these, before, during or after planting.
The active ingredient may be applied to the plant propagation material in any state, one common method being to use the seed in a sufficiently durable state to prevent damage by treating the seed. Typically, the seeds will be harvested from the field and removed from any cob, stalk, husk and surrounding pulp or other non-seed plant material of the plant. The seed is preferably also biostable to the extent that the treatment does not cause biological damage to the seed. The seeds may be treated at any time between harvest and sowing of the seeds, including during sowing.
Methods of applying or treating active ingredients to plant propagation material or a planting site are known in the art and include spraying, coating, granulating, drenching and plug application, furrow application, drenching, soil injection, drip irrigation, application by sprinklers or central pivots, or incorporation into soil (broad throw or strip), alternatively or additionally, the active ingredients may be applied to a suitable substrate which is sown with the plant propagation material.
The application rates of the combinations and compositions of the invention can vary within wide limits, the methods of application (pre-or post-emergence, seed dressing, furrow application, no-tillage application, etc.), the crop plants, the prevailing climatic conditions and other factors controlled by the method of application, the time of application and the target crop. For foliar or drench application, the combinations and compositions of the invention are generally applied at a rate of from 1 to 2000g/ha, in particular from 5 to 1000 g/ha. For seed treatment, the application rate is generally from 0.0005 to 150g per 100kg of seeds.
The combinations and compositions of the present invention may be used in combination with other pesticides, including other pesticides such as insecticides, acaricides, nematicides, fungicides or agents that enhance the activity of the compositions of the present invention, for example in chemical treatment or pest control programs. This combination may have further surprising advantages, which may be described as a synergistic effect.
Suitable further pesticides are, for example, pesticides of the classes of active ingredients such as organophosphates, nitrophenol derivatives, thiourea, juvenile hormones, formamidine, benzophenone derivatives, urea, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acyl ureas, pyridylmethyleneamino derivatives, macrolides, benzoylureas, neonicotinoids and biologicals such as Bacillus thuringiensis strains or bacterially derived insecticides such as spinosyns, avermectins and Cry proteins.
The composition of the present invention can be applied to dicotyledonous crops or monocotyledonous crops. Crops of useful plants in which the compositions of the invention may be used include perennial and annual crops, for example berry plants such as blackberry, blueberry, cranberry, raspberry and strawberry, cereals such as barley, corn (maize) millet, oat, rice, rye, sorghum, triticale and wheat, fibre plants such as cotton, flax, hemp, jute and sisal, field crops such as sugar and fodder beet, coffee, hops, mustard, rape, sugarcane, sunflower, tea and tobacco, fruit trees such as apple, apricot, avocado, banana, cherry, citrus, nectarine, peach, pear and plum, grasses such as bermuda grass, benthos, agrostis, centipede, fescue, ryegrass, st. Augustine Grass and Zoysia Grass, grasses such as basil, borage, chives, coriander, lavender, lovage, mint, oregano, parsley, rosemary sage and thyme, beans such as beans, lentils, peas and soybeans, nuts such as almonds, cashews, ground nuts, hazelnuts, peanuts, pecans, pistachios and walnuts, palm such as oil palm, ornamental plants such as flowers, bushes and trees, other trees such as cocoa, coconut, olives and rubber, vegetables such as asparagus, eggplant, cauliflower, cabbage, carrot, cucumber, garlic, lettuce, bone marrow, melon, okra, onion, pepper, potato, pumpkin, rhubarb, spinach and tomato, and grapevines such as grapes.
Crop plants are to be understood as meaning naturally occurring crop plants which have been obtained by conventional breeding methods or have been obtained by genetic engineering. They include crops that contain so-called yield traits (e.g. improved storage stability, higher nutritional value and improved flavour).
Crops are to be understood as also including those which are tolerant to herbicides such as bromoxynil or which are resistant to such herbicides as ALS-, EPSPS-, GS-, HPPD-and PPO-inhibitors. An example of a crop plant which has been rendered imidazolinone tolerant, e.g.IMAZAMOX grown by conventional methods
Canola in summer. Examples of genetically engineered crop plants tolerant to herbicides include, for example, those under the trade name
Herculex
And
commercial glyphosate and glufosinate resistant corn varieties.
Crops are also to be understood as meaning those crops which naturally have or already have resistance to harmful insects. This includes plants transformed by using recombinant DNA techniques, e.g., capable of synthesizing one or more selectively acting toxins, e.g., toxins known from toxin-producing bacteria. Examples of toxins that may be expressed include D-endotoxins, insecticidal proteins of bacteria of the plant insecticidal protein (VIP) parasitic nematode, and toxins produced by scorpions, spiders, wasps, and fungi.
An example of a crop that has been modified to express a bacillus thuringiensis toxin is a Bt maize knockout (syngenta seed). An example of a crop comprising more than one gene encoding pesticidal resistance and thus expressing more than one toxin is VIPCOT (pro-anodal) seed crop or seed material thereof may also be resistant to multiple types of pests (so-called stacked transgenic events, when produced by genetic modification) TION)
(Dow AgroSciences，Pioneer Hi-Breed International)
Typically, in the management of crops, in addition to the compositions of the present invention, the grower will use one or more other agricultural chemicals or biologicals.
The invention also provides the use of a combination or composition as defined above for controlling pests of the order acarina or pests of the order acarina and insects and/or nematodes.
According to certain aspects of the invention described above, a combination of component (A) selected from A-1 and component (B) selected from compounds B-85 to B-88 can be used to control parasites in or on animals. The invention also provides the use of such a combination for controlling endoparasites and ectoparasites in animals.
The term "control" when used with respect to a parasite in or on an animal means reducing the number of pests or parasites, eliminating the pests or parasites and/or preventing further pest or parasite infestation.
The term "treating" when applied to a parasite in or on an animal refers to inhibiting, slowing, stopping or reversing the progression or severity of an existing symptom or disease.
The term "preventing" when applied to a parasite in or on an animal refers to avoiding the appearance of symptoms or disease in the animal.
The term "animal" when used in the context of parasites in or on an animal can refer to mammals and non-mammals, such as birds or fish. In the case of a mammal, it may be a human or non-human mammal. Non-human mammals include, but are not limited to, livestock animals and companion animals. Livestock includes, but is not limited to, cattle, camellia, pigs, sheep, goats, and horses. Companion animals include, but are not limited to, dogs, cats, and rabbits.
A "parasite" is a pest living in or on a host animal that benefits from gaining nutrition at the expense of the host animal. An "endoparasite" is a parasite that lives in the host animal. An "ectoparasite" is a parasite that is parasitic on a host animal. Ectoparasites include, but are not limited to, mites, insects, nematodes, and crustaceans (e.g., sea lice). The subclass Acarina includes ticks and mites. Ticks include, but are not limited to, members of the genera Scirpus, such as Scirpus fasciatus (Boophilus) Boophilus microplus and Rhipicephalus sanguineus and Orthosiphon. Acarids include, but are not limited to, members of the genera Choroids, such as bovine Choroids, such as ovine itch mite, such as scabies mite insects including, but not limited to, the orders Siphonaptera, diptera, anoploptera, lepidoptera, coleoptera, and Homoptera. Members of the order Siphonaptera include, but are not limited to, ctenocephalides felis and Ctenocephalides canis. Members of the Diptera include, but are not limited to, musca spp. Members of the Haematobia species, such as Haematobia enterogastica and ovine rabies, e.g., the Haematobia irritanssPhhthiraptera species, include, but are not limited to, blood-sucking lice and chewing lice, such as Bovicola ovis and Bovicola bovis.
The term "effective amount" when used with respect to parasites in or on animals, means an amount or dose of a compound of the invention, or a salt thereof, which provides a desired effect in or on the animal when administered in single or multiple doses to the animal. As one skilled in the art, an effective amount can be readily determined by the attending physician, using known techniques and by observing results obtained under analogous circumstances. In determining an effective amount, the dosage regimen selected by the attending diagnostician takes into account a number of factors, including, but not limited to, the particular compound administered for a particular disease or condition involving a species of mammal
The combination of the invention may be administered to an animal by any route having the desired effect, but is not limited to topical, oral, parenteral and subcutaneous administration. Topical administration is preferred. Formulations suitable for topical administration include, for example, solutions, emulsions and suspensions, by spotting, spraying, channeling or dipping. Alternatively, the compounds of the invention may be administered via an ear tag or a collar.
Salt forms of the compounds of the invention include pharmaceutically and veterinarily acceptable salts, which may be different from the agrochemically acceptable salts.
Pharmaceutically and veterinarily acceptable salts and common methods for preparing them are well known in the art. See, for example, gould, P.L. "salt selection of basic drugs", international Journal of pharmaceutics, 33-217 (1986) "salt selection and optimization procedure for Pharmaceutical New chemical entities", organic Process research and development, 4. One skilled in the art of synthesis will recognize that the compounds of the present invention are readily converted to salts and may be isolated as salts, e.g., hydrochloride salts, using techniques and conditions well known to those of ordinary skill in the art. Furthermore, one skilled in the art of synthesis will recognize that the compounds of the invention are readily converted to the corresponding compounds, and that the corresponding compounds can be isolated and the free base removed from the corresponding salt.
The term "seed treatment" generally refers to the application of material to seeds prior to or during planting of the seeds in the soil to improve the germination characteristics of Han seeds, to protect the seeds prior to germination, to support germination and/or to support the growth of the resulting plants. Some seed treatments are intended only to improve the treatment characteristics or other physical characteristics of the seed and do not include agriculturally active ingredients. Other seed treatments incorporate one or more active ingredients onto the seed for various beneficial purposes. For example, seed treatments containing one or more active ingredients are often used to ensure uniform stand establishment by preventing soil-borne diseases. Diseases and insects. Typical examples include the use of insecticides such as fungicides, insecticides, and plant growth regulators. Systemic seed treatment can eliminate, or at least reduce, traditional foliar fungicides or insecticides sprayed for certain early season, airborne diseases and insects.
The seed treatment mixture may also comprise or may be applied together and/or sequentially with other active compounds. These additional compounds may be fertilizers or micronutrient donors or other preparations that influence plant growth, such as inoculants.
As long as the effect of the combination of active ingredients is greater than the sum of the effects of the individual components, there is a synergistic effect. The expected effect E for a given combination of active ingredients follows the so-called Colby formula and can be calculated as follows (Colby, s.r. "calibrating synthetic and antibacterial responses of antibiotic combination". Weeds, vol.15, pages 20-22 1967):
ppm = mg of active ingredient (active ingredient) per liter of liquid medicine
X = percent action with p ppm of first active ingredient
Y = percent action using q ppm of the second active ingredient.
The expected effect of active ingredients A + B using p + q ppm of active ingredient according to the Colby formula is
If the actually observed effect O is greater than the expected effect E, the combined effect is synergistic, i.e. there is a synergistic effect. In mathematical terms, synergy corresponds to positive values of the difference between (O-E). Said difference (O-E) being zero represents an additive effect. A negative value for the difference (O-E) indicates antagonism compared to the expected activity.
Claims (12)
1. A composition characterized by: comprising as component (A) a compound of the formula (A-I) or a salt thereof and as component (B) at least one compound selected from the group consisting of;
at least one compound of component (B) selected from the group consisting of: b-1[ 2- (2, 4-dichlorophenyl) -2-oxo-1-oxaspiro [4.5]]Dec-3-en-4-yl]Butyl carbonate (CAS 1305319-70-3), B-2-flupropathrin (CAS 101007-06-1), B-3 fenazaquin (CAS 120928-09-8), and B-4Flipper TM (C7-C20 fatty acid-containing contact biopesticide/acaricide), B-5N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl]Phenyl radical]Methyl radical]Cyclopropanecarboxamides (CAS 1365070-72-9), B-6 (S) -N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl]Phenyl radical]Methyl radical]Cyclopropanecarboxamide (CAS 2044701-44-0), B-7 Fluxamide (CAS 928783-29-3), B-8Spidoxamat (CAS 907187-07-9), B-9 bromofenoxanilide (CAS 1207727-04-5), B-10Nicofluprole (CAS 1771741-86-6), B-11 cyclopropylflubendiamide (CAS 2375110-88-4), B-12- [ [3- [3, 5-bis (trifluoromethyl) phenyl ] benzamide]-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino]-2, 4-difluoro-phenyl]Benzamide (CAS 2220132-55-6), B-13- [ [ (1R, 3R) -3- [3, 5-bis (trifluoromethyl) phenyl)]-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino group]-2, 4-difluoro-phenyl]Benzamide), B-14- [ [ (1S, 3S) -3- [3, 5-bis (trifluoromethyl) phenyl]-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino]-2, 4-difluoro-phenyl]Benzamide), B-15 tetrachloro-insect benzamide (CAS 1104384-14-6), B-16Afidopyropen (CAS 915972-17-7), B-17-dimethyl-2- [2- (3-pyridinyl) indazol-5-yl]-1,2, 4-triazolidine-3, 5-dione, B-18N- [ 3-chloro-1- (3-pyridyl) pyrazol-4-yl]-2-methanesulfonyl-propionamide (CAS 2396747-83-2), B-19 Tycyclopyrazoflor (CAS 1477919-27-9), B-20N- (1-methylcyclopropyl) -2- (3-pyridyl) indazole-4-carboxamide (CAS 1689545-27-4), B-21 Dimpropyradaz (chemical abstracts No. 1403615-77-9), B-22 flonicamid (CAS 06215867-0), B-23Pyrifluquinazon (CAS 337458-27-2), B-24 pymetrozine (CAS 123312-89-0), B-25 fipronil (CAS 120068-37-3), B-26 3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-benzeneRadical-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-ol salt (CAS 2413839-57-1), B-27 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-alkoxide (CAS 2413390-32-4), B-28 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-olate (enolate tautomer) (CAS 2413839-58-2), B-29 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-alkoxide (dione) (CAS 2246757-58-2), B-30 trifluorophenylpyrimidine (CAS 1263133-33-0), B-31 1- (2-cyanoethyl) -4-oxo-3- [3- (trifluoromethyl) phenyl ] phenyl]Pyrido [1,2-a ]]Pyrimidine-1-2-alkoxide (CAS 2032403-97-5), B-32 imidaclothizine (CAS 1263629-39-5), B-33 imidacloprid (CAS 138261-41-3), B-34 flupirfuranone (CAS 951659-40-8), B-35 thiacloprid (CAS 111988-49-9), B-36 flonicamid (CAS 946578-00-3), B-37 acetamiprid (CAS 135410-20-7), B-38Flupyrimin (CAS 1360-41-2), B-39 dinotefuran (CAS 165252-70-0), b-40 nitenpyram (CAS 150824-47-8), B-41 clothianidin (CAS 210880-92-5), B-42 thiamethoxam (CAS 153719-23-4), B-43 tetrazolium amide (CAS 1229654-66-3), B-44 flubendiamide (CAS 272451-65-7), B-45 chlorantraniliprole (CAS 500008-45-7), B-46 cyantraniliprole (CAS 736994-63-1), B-47 5-bromo-2- (3-chloro-2-pyridyl) -N- [4, 6-dichloro-3-fluoro-2- (methylcarbamoyl) phenyl.]Pyrazole-3-carboxamide (chemical abstracts Co., ltd. No. 2129147-03-9), B-48 Cyclobromantraniliprole (CAS 1031756-98-5), B-49 Chlorofluorocyanide (CAS 1262605-53-7), B-50-bromo-2- (3-chloro-2-pyridyl) -N- [2, 4-dichloro-6- (isopropylaminomethionyl) phenyl]Pyrazole-3-carboxamide (CAS 1442448-92-1), B-51- [6- (2, 2-difluoro-7-methyl- [1, 3)]Dioxolo [4,5-f ]]Benzoimidazol-6-yl) -5-ethanesulfonyl-3-pyridinyl]Cyclopropanecarbonitrile (CAS 2408220-94-8), B-52 6- (5-cyclopropyl-3-ethylsulfonyl-2-pyridinyl) -2, 2-difluoro-7-methyl- [1,3]Dioxacyclopenteno [4,5-f]Benzimidazole (CAS 2408220-91-5), B-53 2- (5-cyclopropyl-3-ethanesulfonyl-2-pyridyl) -5- (trifluoromethylsulfonyl) -1, 3-benzoxazole, B-54 2- [ 3-ethylsulfonyl-5- (trifluoromethyl) pyrazolo [1,5-a ]]Pyridin-2-yl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (C)AS 2133042-44-9), B-55 2- [ 3-ethylsulfonyl-6- (trifluoromethyl) pyrazolo [1,5-a ]]Pyridin-2-yl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (CAS 2133042-31-4), B-56 2- [ 3-ethylsulfonyl-6- (1, 2, 4-triazol-1-yl) -2-pyridinyl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (CAS 1808115-49-2), B-57 2- (3-ethylsulfonyl-2-pyridyl) -5- (2, 3-pentafluoropropoxy) pyrazine (CAS 2095470-94-1), B-58Oxazosulfyl (CAS 1616678-32-0), B-59Benzpyrimoxan (CAS 1449021-97-9), B-60 indoxacarb (CAS 173584-44-6), B-61 metaflumizone (CAS 139968-49-3), B-62 deltamethrin (CAS 52918-63-5), B-63 bifenthrin (CAS 657-04-3) B-64 lambda-cyhalothrin (CAS 76703-62-3), B-65 lambda-cyhalothrin (CAS 1315501-18-8), B-66 alpha-cypermethrin (CAS 67375-30-8), B-67 fenvalerate (CAS 51630-58-1), B-68 cis-fenvalerate B-68 (CAS 66230-04-4), B-69 lambda-cyhalothrin (CAS 91465-08-6), B-70 tefluthrin (CAS 79538-32-2), B-71 (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one, B-72 (R) - (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one, B-73 2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 1445684-82-1), B-74 Flutheniofenox (CAS 1472050-04-6), B-75 Fluffeneim (CAS 170015-32-4), B-76Fluhexafon (CAS 1097630-26-6), B-77 methoxyfenozide (CAS 161050-58-4), B-78 tebufenozide (CAS 112410-23-8), B-79Fluopyram (CAS 658066-35-4), B-80Fluazaindolizine (CAS 1254304-22-7), B-81Guadipyr (CAS 1227849-60-6) B-82 Triflupiride (CAS 179101-81-6), B-83, 4-trifluorobut-3-enyl 2- (2-methoxyphenyl) -5-oxo-tetrahydrofuran-3-carboxylate (CAS 2074661-82-6), B-84Tioxazafen (CAS 330459-31-9), B-85Afoxolaner (CAS 1093861-60-9), B-86Fluralaner (CAS 864731-61-3), B-87Sarolaner (CAS 8613909-39-6), and B-88Tigolaner (CAS 1621436-41-6) or salts thereof.
2. The composition of claim 1, wherein: the weight ratio of (A) to (B) is 500: 1 to 1: 500, 100: 1 to 1: 100, 50:1 to 1: 50 or 20: 1 to 1: 20, or preferably 10: 1 to 1: 10 or 5: 1 to 1: 5.
3. The composition according to claim 1 or claim 2, characterized in that: which further comprises one or more auxiliaries and/or diluents.
4. A method of controlling or preventing damage to a plant, comprising: which comprises applying on the plant, its locus or its propagation material, in any desired sequence or simultaneously, as component (a) a mixture comprising a compound of formula (a-I), an agrochemically acceptable salt thereof and as component (B) at least one compound selected from the group consisting of;
b-1[ 2- (2, 4-dichlorophenyl) -2-oxo-1-oxaspiro [4.5]]Dec-3-en-4-yl]Butyl carbonate (CAS 1305319-70-3), B-2-flupropathrin (CAS 101007-06-1), B-3 fenazaquin (CAS 120928-09-8), and B-4Flipper TM (C7-C20 fatty acid-containing contact biopesticide/acaricide), B-5N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl]Phenyl radical]Methyl radical]Cyclopropanecarboxamides (CAS 1365070-72-9), B-6 (S) -N- [ [ 2-fluoro-4- [ 2-hydroxy-3- (3, 4, 5-trichlorophenyl) -3- (trifluoromethyl) pyrrolidin-1-yl]Phenyl radical]Methyl radical]Cyclopropanecarboxamide (CAS 2044701-44-0), B-7 Fluxamide (CAS 928783-29-3), B-8Spidoxamat (CAS 907187-07-9), B-9 bromofenoben-ben-zamide (CAS 1207727-04-5), B-10 Nicofluprolole (CAS 1771741-86-6), B-11 Cyclopropaneflunomide (CAS 2375110-88-4), B-12- [ [3- [3, 5-bis (trifluoromethyl) phenyl ] 5- [ []-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino group]-2, 4-difluoro-phenyl]Benzamide (CAS 2220132-55-6), B-13- [ [ (1R, 3R) -3- [3, 5-bis (trifluoromethyl) phenyl)]-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino]-2, 4-difluoro-phenyl]Benzamide), B-14- [ [ (1S, 3S) -3- [3, 5-bis (N-methyl-N-ethyl-) (1S, 3S)Trifluoromethyl) phenyl]-2, 2-dichloro-cyclopropanecarbonyl]Amino group]-2-chloro-N- [3- [ (2, 2-difluoroacetyl) amino]-2, 4-difluoro-phenyl]Benzamide), B-15 tetrachloro-insect benzamide (CAS 1104384-14-6), B-16Afidopyropen (CAS 915972-17-7), B-17-dimethyl-2- [2- (3-pyridinyl) indazol-5-yl]-1,2, 4-triazolidine-3, 5-dione, B-18N- [ 3-chloro-1- (3-pyridyl) pyrazol-4-yl]-2-methanesulfonyl-propionamide (CAS 2396747-83-2), B-19Tyclopyrazoflor (CAS 1477919-27-9), B-20N- (1-methylcyclopropyl) -2- (3-pyridyl) indazole-4-carboxamide (CAS 1689545-27-4), B-21Dimpropyridaz (chemical abstracts No. 1403615-77-9), B-22 flonicamid (CAS 06215867-0), B-23Pyrifluquinazon (CAS 7458-27-2), B-24 pymetrozine (CAS 123312-89-0), B-25 fipronil (CAS 120068-37-3), B-26 3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-alkoxide (CAS 2413839-57-1), B-27 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-alkoxide (CAS 2413390-32-4), B-28 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-ol (enolate tautomer) (CAS 2413839-58-2), B-29 (3R) -3- (2-chlorothiazol-5-yl) -8-methyl-5-oxo-6-phenyl-2, 3-dihydrothiazolo [3,2-a ]]Pyrimidin-8-ium-7-alkoxide (dione) (CAS 2246757-58-2), B-30 trifluoropyrimidine (CAS 1263133-33-0), B-31- (2-cyanoethyl) -4-oxo-3- [3- (trifluoromethyl) phenyl]Pyrido [1,2-a ]]Pyrimidine-1-2-alkoxide (CAS 2032403-97-5), B-32 imidaclothizine (CAS 1263629-39-5), B-33 imidacloprid (CAS 138261-41-3), B-34 flupirfuranone (CAS 951659-40-8), B-35 thiacloprid (CAS 111988-49-9), B-36 flonicamid (CAS 946578-00-3), B-37 acetamiprid (CAS 135410-20-7), B-38Flupyrimin (CAS 1360-41-2), B-39 dinotefuran (CAS 165252-70-0), b-40 nitenpyram (CAS 150824-47-8), B-41 clothianidin (CAS 210880-92-5), B-42 thiamethoxam (CAS 153719-23-4), B-43 tebuconazole (CAS 1229654-66-3), B-44 flubendiamide (CAS 272451-65-7), B-45 chlorantraniliprole (CAS 500008-45-7), B-46 cyantraniliprole (CAS 736994-63-1), B-47 5-bromo-2- (3-chloro-2-pyridyl) -N- [4, 6-dichloro-3-fluoro-2- (methylcarbamoyl) phenyl.]Pyrazole-3-carboxamides(chemical abstracts Co., ltd. No. 2129147-03-9), B-48 Cyclobromantraniliprole (CAS 1031756-98-5), B-49 chlorofluorocarbonaniliprole (CAS 1262605-53-7), B-50 5-bromo-2- (3-chloro-2-pyridyl) -N- [2, 4-dichloro-6- (isopropylaminomethionyl) phenyl ] -2, 4-dichloro-6-methyl-aminothionamide]Pyrazole-3-carboxamide (CAS 1442448-92-1), B-51- [6- (2, 2-difluoro-7-methyl- [1, 3)]Dioxolo [4,5-f ]]Benzoimidazol-6-yl) -5-ethanesulfonyl-3-pyridinyl]Cyclopropanecarbonitrile (CAS 2408220-94-8), B-52 6- (5-cyclopropyl-3-ethylsulfonyl-2-pyridyl) -2, 2-difluoro-7-methyl- [1,3]Dioxolo [4,5-f ]]Benzimidazole (CAS 2408220-91-5), B-53 2- (5-cyclopropyl-3-ethanesulfonyl-2-pyridyl) -5- (trifluoromethylsulfonyl) -1, 3-benzoxazole, B-54 2- [ 3-ethylsulfonyl-5- (trifluoromethyl) pyrazolo [1,5-a ]]Pyridin-2-yl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (CAS 2133042-44-9), B-55 2- [ 3-ethylsulfonyl-6- (trifluoromethyl) pyrazolo [1,5-a ]]Pyridin-2-yl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (CAS 2133042-31-4), B-56 2- [ 3-ethylsulfonyl-6- (1, 2, 4-triazol-1-yl) -2-pyridinyl]-3-methyl-6- (trifluoromethyl) imidazo [4,5-b]Pyridine (CAS 1808115-49-2), B-57 2- (3-ethylsulfonyl-2-pyridyl) -5- (2, 3-pentafluoropropoxy) pyrazine (CAS 2095470-94-1), B-58Oxazosulfyl (CAS 1616678-32-0), B-59Benzpyrimoxan (CAS 1449021-97-9), B-60 indoxacarb (CAS 173584-44-6), B-61 metaflumizone (CAS 139968-49-3), B-62 deltamethrin (CAS 52918-63-5), B-63 bifenthrin (82657-04-3) B-64 lambda-cyhalothrin (CAS 76703-62-3), B-65 lambda-cyhalothrin (CAS 1315501-18-8), B-66 alpha-cypermethrin (CAS 67375-30-8), B-67 fenvalerate (CAS 51630-58-1), B-68 cis-fenvalerate B-68 (CAS 66230-04-4), B-69 lambda-cyhalothrin (CAS 91465-08-6), B-70 tefluthrin (CAS 79538-32-2), B-71 (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl ] ethyl-5]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one, B-72 (R) - (2Z) -2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one, B-73 2- [ 2-fluoro-4-methyl-5- (2, 2-trifluoroethylsulfinyl) phenyl]Imino-3- (2, 2-trifluoroethyl) thiazolidin-4-one (CAS 1445684-82-1), B-74Flupentiofenox (CAS 1472050-04-6), B-75Flufenerim (C)AS 170015-32-4), B-76Fluhexafon (CAS 1097630-26-6), B-77 methoxyfenozide (CAS 161050-58-4), B-78 tebufenozide (CAS 112410-23-8), B-79Fluopyram (CAS 658066-35-4), B-80Fluazaindolizine (CAS 1254304-22-7), B-81Guadipyr (CAS 1227849-60-6), B-82 trifluralin (CAS 179101-81-6), B-83,3, 4-trifluorobut-3-enyl 2- (2-methoxyphenyl) -5-oxo-tetrahydrofuran-3-carboxylate (CAS 2074661-82-6), B-84Tioxazafen (CAS 330459-31-9), or an agrochemically acceptable salt thereof.
5. The method according to claim 4, characterized in that: the amount of component (A) applied is from 1 to 2000g/ha, preferably from 10 to 1000g/ha, more preferably from 20 to 200g/ha.
6. A method of controlling or preventing infection in an animal comprising: which comprises administering to an animal, in any desired sequence or simultaneously, a composition comprising as component (a) a compound of formula (a-I), a veterinarily acceptable salt thereof and as component (B) at least one compound selected from the group consisting of or a pharmaceutically or veterinarily acceptable salt thereof;
at least one compound of component (B) selected from the group consisting of or a pharmaceutically or veterinarily acceptable salt thereof;
B-85Afoxolaner(CAS 1093861-60-9)
B-86Fluralaner(CAS 864731-61-3)
b-87Sarolaner (CAS 1398609-39-6) and
b-88 Tigolner (CAS 1621436-41-6) or a pharmaceutically or veterinarily acceptable salt thereof.
7. Use of a combination comprising as component (a) a compound of formula (a-I) characterized in that: the use of a compound of formula (a-I), a veterinarily acceptable salt thereof, of component (a) and as component (B) at least one compound selected from the following or a pharmaceutically or veterinarily acceptable salt thereof, in the control or prevention of an animal; wherein, the first and the second end of the pipe are connected with each other,
or a pharmaceutically or veterinarily acceptable salt thereof;
B-85Afoxolaner(CAS 1093861-60-9)、
B-86Fluralaner(CAS 864731-61-3)、
b-87Sarolaner (CAS 1398609-39-6) and
b-88Tigolaner (CAS 1621436-41-6) or a pharmaceutically or veterinarily acceptable salt thereof.
8. Use of the composition according to any one of claims 1 to 3 as acaricide or acaricide, insecticide and/or nematicide.
9. The method of any one of claims 4 to 6 or the use of claim 7 or claim 8, wherein components (A) and (B) are administered sequentially, simultaneously or as a composition comprising (A) and (B).
10. The method of any one of claims 4 to 6 or claim 9, or the use of any one of claims 7 to 9, wherein the combination is used to control one or more pests of insects, acarids and nematodes.
11. A formulation, characterized by: comprising a composition according to any one of claims 1 to 3, said formulation comprising 0.01 to 90 weight percent of active ingredient, 0 to 25 weight percent of agriculturally or pharmaceutically acceptable surfactant and 10 to 99.9 weight percent of solid or liquid formulation inerts and adjuvants.
12. A concentrate composition for dilution by a user, the concentrate composition characterized by: the concentrate composition comprising the composition of any one of claims 1 to 3, comprising 2 to 80% by weight active ingredient, preferably about 5 to 70% by weight active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110813291.6A CN115633687A (en) | 2021-07-19 | 2021-07-19 | Composition for preventing and treating mites, insects and nematodes and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110813291.6A CN115633687A (en) | 2021-07-19 | 2021-07-19 | Composition for preventing and treating mites, insects and nematodes and application |
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| Publication Number | Publication Date |
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| CN115633687A true CN115633687A (en) | 2023-01-24 |
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116508749A (en) * | 2023-07-03 | 2023-08-01 | 四川科宏达集团有限责任公司 | Herbicide synergistic auxiliary agent and application thereof |
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2021
- 2021-07-19 CN CN202110813291.6A patent/CN115633687A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116508749A (en) * | 2023-07-03 | 2023-08-01 | 四川科宏达集团有限责任公司 | Herbicide synergistic auxiliary agent and application thereof |
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