CN1156274C - Medicinal ointment containing zinc conjugated linoleate and sodium humate - Google Patents
Medicinal ointment containing zinc conjugated linoleate and sodium humate Download PDFInfo
- Publication number
- CN1156274C CN1156274C CNB021086044A CN02108604A CN1156274C CN 1156274 C CN1156274 C CN 1156274C CN B021086044 A CNB021086044 A CN B021086044A CN 02108604 A CN02108604 A CN 02108604A CN 1156274 C CN1156274 C CN 1156274C
- Authority
- CN
- China
- Prior art keywords
- conjugated linoleate
- zinc conjugated
- zinc
- linoleate
- sodium humate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a medicinal ointment containing sodium humate and zinc salt of conjugated linoleic acid, which is composed of zinc salt of conjugated linoleic acid, sodium humate, medicinal white oil, distilled water, a surface active agent and an oxidation inhibitor. The preparation method comprises the following steps: the medicinal white oil is heated, the zinc salt of conjugated linoleic acid and the oxidation inhibitor are added; then, the sodium humate is added to the distilled water and stirred so that the sodium humate is dissolved before the solution is added to a mixture of the medicinal white oil; the surface active agent is added for emulsification and cooled to a room temperature. The medicinal ointment has unique therapeutic effect lacking in the single use of the zinc salt of conjugated linoleic acid or the sodium humate; the medicinal ointment can effectively inhibit the propagation of fungi and bacteria and treat skin cancerization, namely that the medicinal ointment has double efficiency of suppressing inflammation and treating cancer; the present invention has particular effect on treating eczema, psoriasis, dermatitis and skin carcinomas.
Description
Technical field
The present invention relates to a kind of medical external-applied ointment, especially a kind of cream that contains zinc conjugated linoleate and sodium humate.
Background technology
Conjugated linoleic acid (Conjugated Linoleic Acid, be called for short CLA) is the mixture that contains a series of octadecadienoic acids of conjugated double bond, and these octadecadienoic acids exist configuration and conformation different isomer as 9-c, 11-c; 10-c, 12-c; 9-t, 11-t; 10-t, 12-t; 9-t, 11-c; 9-c, 11-t; 10-c, 12-t; 10-t, 12-c; In French cheese, found 8,10 and 11,13 isomer afterwards again.
Up to the present, discover 9-c, 11-t and 10-t, 12-c are two kinds of maximum isomers of content in the conjugated linoleic acid, and its chemical formula is:
Conjugated linoleic acid is paid close attention to by increasing scientific research both at home and abroad and medical institutions with the health care of its excellence, disease-resistant function, and competitively develops the product at food, medicine and feed industry.Conjugated linoleic acid can be induced the energy utilization and be caused the decline of body weight, and does not store fat (United States Patent (USP) 5,554,646; United States Patent (USP) 5,814,663; World patent PCT WO 97/46230), promotes effective absorption (United States Patent (USP) 5,428,072) of food, after the athlete is edible, can slow down metabolism, strengthen endurance (United States Patent (USP) 5,919,767); Can relax as immunoreactive side effect (United States Patent (USP) 5,430,066 such as anorexia, protein decomposition; United States Patent (USP) 5,585,400); Have mutation, the protection humans and animals is avoided the effects (United States Patent (USP) 6,214,372) such as injury of a series of cancers; Conjugated linoleic acid also can improve human some physiological status, as improving the level of vitamin A in the body, reduces body inner cholesterol, LDL cholesterol (European patent 779,033 A1); Can change the skeleton abnormal state, keep even increase skeleton content of mineral substances (United States Patent (USP) 5,814,210).
The potassium of conjugated linoleic acid, sodium salt can be as the antiseptic of food, feedstuff, the double simultaneously alimentary health-care function that occupies.(EP?411,101)
Double nutrition and the calcium-enriching function of occupying of the calcium salt of conjugated linoleic acid.It can change the skeleton abnormal state, keeps even increases skeleton content of mineral substances (United States Patent (USP) 5,814,210).
The zinc salt of conjugated linoleic acid can be treated the various skin disease, as eczema, psoriasis, dermatitis, skin carcinoma etc.(United States Patent (USP) 62288115)
Discover that sodium humate can be used for treating dermatitis and eczema.Sodium humate is the sodium-salt form of humic acid, comprises sodium fulvate, humic acid sodium, ulmic acid sodium.Humic acid can suppress pathogenic bacterium such as staphylococcus epidermidis, staphylococcus aureus, streptococcus pyogenes, bacillus typhi murium, Bacillus proteus, bacillus pyocyaneus, Candida albicans in finite concentration.Proved that now it can a large amount of lead of chelating and cadmium, so can be used as the heavy metal detoxification agent.Sodium fulvate has antiinflammatory, antiviral, pain relieving, hemostasis, has effect, removing the necrotic tissue and promoting granulation to promote tissue growth to ulcer, and activating blood circulation to dissipate blood stasis increases effects such as immunologic function.Sodium fulvate also has certain curative effect to its ulcer of recurrent Ah not, herpetic stomatitis, infectious stomatitis and periodontitis etc.Fields such as physiologically active are more common in research about sodium humate, and Shang Weijian has the prescription report.
In many prior arts, do not see the report that the cream that contains zinc conjugated linoleate and sodium humate is arranged both at home and abroad as yet.
Summary of the invention
The object of the invention is, according to the characteristics of inferior sour zinc salt of conjugation and sodium humate, has developed a kind of cream that contains zinc conjugated linoleate and sodium humate.This ointment is made up of zinc conjugated linoleate, sodium humate, medicinal white oils, distilled water, surfactant, antioxidant.Medicinal white oils is heated in employing, adds zinc conjugated linoleate and antioxidant under stirring condition; Sodium humate is joined in the distilled water, stirring joins solution in the mixture of medicinal white oils after making its dissolving, adds surfactant, carries out emulsifying, is cooled to room temperature and gets final product again.This cream has independent use zinc conjugated linoleate and uses the unexistent unique curative effect of sodium humate separately, can effectively suppress the breeding of fungus, antibacterial, can treat the canceration of skin again, and inflammation-inhibiting and treatment cancer double effects are promptly arranged.Treatment eczema, psoriasis, dermatitis, skin carcinoma there is specially good effect.
A kind of cream that contains zinc conjugated linoleate and sodium humate that the present invention developed, this cream is made up of zinc conjugated linoleate, sodium humate, medicinal white oils, distilled water, surfactant, antioxidant; Employing will add zinc conjugated linoleate and antioxidant in the medicinal white oils; Sodium humate is joined in the distilled water, stirring joins solution in the medicinal white oils mixture after making its dissolving, adds surfactant, carries out emulsifying again, and the method that is cooled to room temperature is made; Wherein each set of dispense ratio is: mass ratio
Zinc conjugated linoleate: sodium humate: medicinal white oils: distilled water: surfactant: antioxidant, ratio are 10-40: 10-40: 20-70: 5-45: 0.1-2: 0.01-0.3;
The preparation method of cream follows these steps to carry out:
At first medicinal white oils is heated to 50-70 ℃, stirring condition adds zinc conjugated linoleate and antioxidant down, obtains A liquid;
Sodium humate is joined in the distilled water, and stirring is heated to 50-70 ℃ after making its dissolving, obtains B liquid;
In A liquid, add B liquid and surfactant then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 0.5-3 hour.
Zinc conjugated linoleate used in the cream comprises: suitable-9, instead-11-zinc conjugated linoleate or anti--9, suitable-11-zinc conjugated linoleate or suitable-9, suitable-11-zinc conjugated linoleate or anti--9, instead-11-zinc conjugated linoleate or trans-10, suitable-12-zinc conjugated linoleate or suitable-10, instead-12-zinc conjugated linoleate or suitable-10, suitable-12-zinc conjugated linoleate or trans-10, instead-and 12-zinc conjugated linoleate or suitable-8, trans-10-zinc conjugated linoleate or anti--8, suitable-10-zinc conjugated linoleate or suitable-8, suitable-10-zinc conjugated linoleate or anti--8, trans-10-zinc conjugated linoleate or anti--11, suitable-13-zinc conjugated linoleate or suitable-11, anti--13-zinc conjugated linoleate or suitable-11, suitable-13-zinc conjugated linoleate or anti--11, anti--13-zinc conjugated linoleate or some kinds mixture wherein.
Used antioxidant comprises one or more mixture in pyrogallic acid ethyl ester or pyrogallic acid propyl ester or tertiarybutylhydroquinone or butylated hydroxyarisol or the Yoshinox BHT in the cream.
Used surfactant comprises one or more the mixture in span or castor oil polyoxyethylene ether or Olestra or glyceryl monostearate or distearin or methyl glycol fatty acid ester or xylitol fatty acid ester or the fatty acid sorbitol ester in the cream.
Used sodium humate comprises one or more the mixture in sodium fulvate or ulmic acid sodium or the humic acid sodium in the cream.
A kind of cream that contains zinc conjugated linoleate and sodium humate of the present invention, through observing to suffering from surplus acne, breast ulcer, urticaria, dermatitis, eczema, psoriasis, skin pruritus, sunburn, herpesvirus infection, the skin carcinoma etc. 100 routine patient's clinical result of use, its effective percentage 99%, cure rate 85%.
A kind of cream that contains zinc conjugated linoleate and sodium humate of the present invention is coated in the surface, affected part to acne with ointment during use, and every day one to twice, symptom is eased very soon, treats and can fully recover after one month.Ointment can be coated in the affected part to the patient who suffers from slight urticaria, eczema, dermatitis, psoriasis, skin carcinoma etc., 3-7 days, effective percentage 99%; To moderate needs of patients 15-20 days, effective percentage 99%; To severe needs of patients 1-4 month, effective percentage 99%.
To skin pruritus, sunburn, herpesvirus infection, etc. disease, ointment is coated in the affected part, relieve the pain very soon, can fully recover after 10 days.
The specific embodiment
Embodiment 1
At first taking by weighing each component by mass ratio is: suitable-9, instead-and the 11-zinc conjugated linoleate: ulmic acid sodium and humic acid sodium mixture: medicinal white oils: distilled water: Span: tertiarybutylhydroquinone, its ratio are 30.15: 31.6: 28.14: 10: 0.1: 0.01;
28.14 parts of medicinal white oils are heated to 50 ℃, and it is suitable-9 that stirring condition adds down, and 0.01 part of anti--30.15 parts of 11-zinc conjugated linoleates and antioxidant tertiarybutylhydroquinone obtain A liquid;
31.6 parts in ulmic acid sodium and humic acid sodium mixture joined in 10 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add 0.1 part of B liquid and surfactant Span then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 0.5 hour.
Embodiment 2
At first taking by weighing each component by mass ratio is: anti--9, suitable-11-zinc conjugated linoleate and trans-10, the mixture of suitable-12-zinc conjugated linoleate: ulmic acid sodium: medicinal white oils: distilled water: Olestra: butylated hydroxyarisol, its ratio are 30: 40: 24.77: 5: 0.2: 0.03;
24.77 parts of medicinal white oils are heated to 70 ℃, and it is anti--9 that stirring condition adds down, suitable-11-zinc conjugated linoleate and trans-10, and each 15 parts of suitable-12-zinc conjugated linoleates and antioxidant tertiary butyl p-hydroxyanisole obtain A liquid for 0.03 part;
40 parts in ulmic acid sodium is joined in 5 parts of the distilled water, stir and make its dissolving, be heated to 60 ℃, obtain B liquid;
In A liquid, add 0.2 part of B liquid and surfactant Olestra then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 3 hours.
Embodiment 3
At first taking by weighing each component by mass ratio is: trans-10, suitable-12-zinc conjugated linoleate and suitable-9, instead-and the mixture of 11-zinc conjugated linoleate: sodium fulvate: medicinal white oils: distilled water: glyceryl monostearate: Yoshinox BHT, its ratio are 35: 25: 20: 19.18: 0.8: 0.02;
20 parts of medicinal white oils are heated to 60 ℃, and stirring condition adds down trans-10, suitable-12-zinc conjugated linoleate and suitable-9, and 0.02 part of each 17.5 parts of anti--11-zinc conjugated linoleates and antioxidant Yoshinox BHT obtain A liquid;
25 parts of sodium fulvate are joined in 19.18 parts of the distilled water, stir and make its dissolving, be heated to 50 ℃, obtain B liquid;
In A liquid, add 0.8 part of B liquid and surfactant glyceryl monostearate then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 2 hours.
Embodiment 4
At first taking by weighing each component by mass ratio is: suitable-11, instead-13-zinc conjugated linoleate and trans-10, suitable-12-zinc conjugated linoleate and anti--9, the mixture of suitable-11-zinc conjugated linoleate: humic acid sodium: medicinal white oils: distilled water: methyl glycol fatty acid ester: pyrogallic acid ethyl ester, its ratio are 40: 10: 35: 12.8: 2: 0.2;
35 parts of medicinal white oils are heated to 70 ℃, stirring condition adds suitable-11 down, instead-13 zinc conjugated linoleate and trans-10, suitable-12-zinc conjugated linoleate and anti--9, suitable-11-zinc conjugated linoleate is respectively 0.2 part of 10 parts, 15 parts and 15 parts and antioxidant pyrogallic acid ethyl ester, obtains A liquid;
10 parts in humic acid sodium is joined in 12.8 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add 2 parts of B liquid and surfactant methyl glycol fatty acid esters then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 1.5 hours.
Embodiment 5
At first taking by weighing each component by mass ratio is: anti--11, instead-13-zinc conjugated linoleate and suitable-9, the mixture of suitable-11-zinc conjugated linoleate: sodium fulvate and ulmic acid sodium mixture: medicinal white oils: distilled water: castor oil polyoxyethylene ether and single hard fatty acids glyceride mixture: tertiarybutylhydroquinone, its ratio are 25: 15: 33: 25: 1.7: 0.3;
33 parts of medicinal white oils are heated to 60 ℃, and it is anti--11 that stirring condition adds down, and anti--13-zinc conjugated linoleate and suitable-9, suitable-11-zinc conjugated linoleate are respectively 10 parts and 15 parts and 0.3 part of antioxidant tertiarybutylhydroquinone, obtain A liquid;
15 parts in sodium fulvate and ulmic acid sodium mixture joined in 25 parts of the distilled water, stir and make its dissolving, be heated to 50 ℃, obtain B liquid;
In A liquid, add 1.7 parts in B liquid and surfactant castor oil polyoxyethylene ether and single hard fatty acids glyceride mixture then,, be cooled to room temperature, obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 2 hours.
Embodiment 6
At first taking by weighing each component by mass ratio is: suitable-10, suitable-the 12-zinc conjugated linoleate: humic acid sodium: medicinal white oils: distilled water: xylitol fatty acid ester and fatty acid sorbitol ester mixture: pyrogallic acid ethyl ester, its ratio are 15: 15: 24: 45: 0.8: 0.2;
Medicinal white oils is heated to 70 ℃ for 24 parts, and 0.2 part of suitable-10 to wherein adding, suitable under the stirring condition-15 parts of 12-zinc conjugated linoleates and antioxidant pyrogallic acid ethyl ester obtain A liquid;
15 parts in humic acid sodium is joined in 45 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add each 0.4 part in B liquid and surfactant xylitol fatty acid ester and fatty acid sorbitol ester mixture then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 1.5 hours.
Embodiment 7
At first taking by weighing each component by mass ratio is: suitable-8, trans-10-zinc conjugated linoleate: sodium fulvate and humic acid sodium and ulmic acid sodium mixture: medicinal white oils: distilled water: distearyl fatty acid glyceride: tertiarybutylhydroquinone, its ratio are 15: 24: 32: 27.2: 1.5: 0.3;
32 parts of medicinal white oils are heated to 70 ℃, and it is suitable-8 that stirring condition adds down, and 0.3 part of 15 parts of trans-10 zinc conjugated linoleates and antioxidant tertiarybutylhydroquinone obtain A liquid;
Each 8 parts in sodium fulvate and humic acid sodium and ulmic acid sodium mixture joined in 27.2 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add 1.5 parts of B liquid and surfactant tertiarybutylhydroquinonees then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 1.5 hours.
Embodiment 8
At first taking by weighing each component by mass ratio is: anti--11, instead-and the 13-zinc conjugated linoleate: ulmic acid sodium: medicinal white oils: distilled water: methyl glycol fatty acid ester and Olestra and castor oil polyoxyethylene ether mixture: butylated hydroxyarisol, its ratio are 30: 25: 28: 14.8: 2: 0.2;
28 parts of medicinal white oils are heated to 70 ℃, and it is anti--11 that stirring condition adds down, and 0.2 part of 30 parts of anti--13 zinc conjugated linoleates and antioxidant tertiary butyl p-hydroxyanisole obtain A liquid;
25 parts in ulmic acid sodium is joined in 14.8 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add 0.8,0.7,0.5 part in B liquid and surfactant methyl glycol fatty acid ester and Olestra and castor oil polyoxyethylene ether mixture then, with powerful mulser emulsifying 1.5 hours, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate.
Embodiment 9
At first taking by weighing each component by mass ratio is: suitable-10, suitable-12-zinc conjugated linoleate and trans-10, the mixture of suitable-12-zinc conjugated linoleate: humic acid sodium: medicinal white oils: distilled water: xylitol fatty acid ester and fatty acid sorbitol ester mixture: pyrogallic acid ethyl ester, its ratio are 10: 10: 70: 8.8: 1: 0.2;
Medicinal white oils is heated to 70 ℃ for 70 parts, suitable-10 under the stirring condition to wherein adding, suitable-12-zinc conjugated linoleate and trans-10,0.2 part of each 5 parts of suitable-12-zinc conjugated linoleates and antioxidant pyrogallic acid ethyl ester obtain A liquid;
10 parts in humic acid sodium is joined in 8.8 parts of the distilled water, stir and make its dissolving, be heated to 70 ℃, obtain B liquid;
In A liquid, add each 0.5 part in B liquid and surfactant xylitol fatty acid ester and fatty acid sorbitol ester mixture then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 1.5 hours.
Claims (6)
1, a kind of cream that contains zinc conjugated linoleate and sodium humate is characterized in that this cream is made up of zinc conjugated linoleate, sodium humate, medicinal white oils, distilled water, surfactant, antioxidant; Employing will add zinc conjugated linoleate and antioxidant in the medicinal white oils; Sodium humate is joined in the distilled water, stirring joins solution in the medicinal white oils mixture after making its dissolving, adds surfactant, carries out emulsifying again, and the method that is cooled to room temperature is made; Wherein each set of dispense ratio is: mass ratio
Zinc conjugated linoleate: sodium humate: medicinal white oils: distilled water: surfactant: antioxidant, ratio are 10-40: 10-40: 20-70: 5-45: 0.1-2: 0.01-0.3.
2, a kind of preparation method that contains the cream of zinc conjugated linoleate and sodium humate according to claim 1 is characterized in that following these steps to carrying out:
At first medicinal white oils is heated to 50-70 ℃, stirring condition adds zinc conjugated linoleate and antioxidant down, obtains A liquid;
Sodium humate is joined in the distilled water, and stirring is heated to 50-70 ℃ after making its dissolving, obtains B liquid;
In A liquid, add B liquid and surfactant then,, be cooled to room temperature, can obtain a kind of cream that contains zinc conjugated linoleate and sodium humate with powerful mulser emulsifying 0.5-3 hour.
3, a kind of preparation method that contains the cream of zinc conjugated linoleate and sodium humate according to claim 2, it is characterized in that used zinc conjugated linoleate comprises: suitable-9, instead-11-zinc conjugated linoleate or anti--9, suitable-11-zinc conjugated linoleate or suitable-9, suitable-11-zinc conjugated linoleate or anti--9, instead-11-zinc conjugated linoleate or trans-10, suitable-12-zinc conjugated linoleate or suitable-10, instead-12-zinc conjugated linoleate or suitable-10, suitable-12-zinc conjugated linoleate or trans-10, instead-12-zinc conjugated linoleate or suitable-8, trans-10-zinc conjugated linoleate or anti--8, suitable-10-zinc conjugated linoleate or suitable-8, suitable-10-zinc conjugated linoleate or anti--8, trans-10-zinc conjugated linoleate or anti--11, suitable-13-zinc conjugated linoleate or suitable-11, instead-and 13-zinc conjugated linoleate or suitable-11, suitable-13-zinc conjugated linoleate or anti--11, the mixture of one or more of anti--13-zinc conjugated linoleate.
4, a kind of cream that contains zinc conjugated linoleate and sodium humate according to claim 1 is characterized in that antioxidant comprises pyrogallic acid ethyl ester or pyrogallic acid ethyl ester or tertiarybutylhydroquinone or butylated hydroxyarisol or Yoshinox BHT.
5, surfactant according to claim 1 is characterized in that used surfactant comprises one or more mixture in span or castor oil polyoxyethylene ether or Olestra or glyceryl monostearate or distearin or methyl glycol fatty acid ester or xylitol fatty acid ester or the fatty acid sorbitol ester.
6, a kind of cream that contains zinc conjugated linoleate and sodium humate according to claim 1 is characterized in that used sodium humate comprises one or more the mixture in sodium fulvate or ulmic acid sodium or the humic acid sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021086044A CN1156274C (en) | 2002-03-28 | 2002-03-28 | Medicinal ointment containing zinc conjugated linoleate and sodium humate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021086044A CN1156274C (en) | 2002-03-28 | 2002-03-28 | Medicinal ointment containing zinc conjugated linoleate and sodium humate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1372926A CN1372926A (en) | 2002-10-09 |
| CN1156274C true CN1156274C (en) | 2004-07-07 |
Family
ID=4740344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021086044A Expired - Fee Related CN1156274C (en) | 2002-03-28 | 2002-03-28 | Medicinal ointment containing zinc conjugated linoleate and sodium humate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1156274C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ543486A (en) * | 2005-11-10 | 2009-03-31 | Fonterra Corporate Res And Dev | Compositions of CIS-9, trans-11 conjugated linoleic acid and vaccenic acid and uses thereof |
| TR201003579A2 (en) * | 2010-05-06 | 2010-07-21 | Di̇zman Mümi̇n | Treatment of upper and lower skin diseases with a topical and injectable wound healing agent. |
| CN104306587B (en) * | 2014-10-11 | 2017-12-22 | 昆明理工大学 | A kind of blister antipruritic liquid that disappears for bite by mosquitos |
| CN105998066A (en) * | 2016-06-28 | 2016-10-12 | 俞瑞山 | Application method of sodium humate serving as orally taken medicine for curing stomach illness and gynecological inflammation |
| CN106266453A (en) * | 2016-08-31 | 2017-01-04 | 郑向东 | A kind of composition for external application and application thereof |
| CN112451512A (en) * | 2020-11-26 | 2021-03-09 | 青海省人民医院 | Pharmaceutical composition and application thereof in treating osteoporosis |
-
2002
- 2002-03-28 CN CNB021086044A patent/CN1156274C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1372926A (en) | 2002-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1259034C (en) | Leech extract cosmetics and method for making same | |
| JP2009504588A (en) | Composition of n-3 fatty acids having a high concentration of EPA and / or DHA and containing n-6 fatty acids | |
| KR20070040369A (en) | Compositions for topical treatment | |
| US11173181B2 (en) | Camel hump-oil based herbal compositions and method of making the same | |
| US20100074963A1 (en) | Red Palm Oil and Fish Oil Wound Dressing | |
| CA2966325A1 (en) | Formulations containing pomegranate seed oil, rosa canina fruit oil and inula viscosa oleoresin or extract. | |
| US10463699B2 (en) | Fish oil topical composition | |
| CN1156274C (en) | Medicinal ointment containing zinc conjugated linoleate and sodium humate | |
| US11109607B2 (en) | Oil-based compositions for enhancing oral health and general wellness in humans | |
| DE202008006708U1 (en) | Combination of tocotrienols with long-chain fatty acids for health maintenance, pain relief and anti-inflammatory | |
| US20140005266A1 (en) | Topical formulations for administration of omega-3 fatty acids | |
| CN1122528C (en) | Composite safflower oil preparation and medicine containing it | |
| CN1393221A (en) | Liquid medicine for treating acne | |
| CN1919063A (en) | Health care food with disease removing and body strengthening function and making method thereof | |
| CN1244398A (en) | Improved tincture with both Chinese and Western medicines for dermatomycosis | |
| CN108785493B (en) | A composition for treating dermatoses, and its preparation method | |
| CN101966263A (en) | SOD (Super Oxide Dlsmutase) oxidation-resistant health product | |
| CN1921852A (en) | Use of metronidazole for preparing a pharmaceutical composition for treating pathologies related to the b-type receptor of interleukin 8 and/or to a pacap type 1 receptor | |
| CN118303531A (en) | Additive composition and application thereof | |
| KR101681907B1 (en) | Composition for promoting circulation of blood and improving skin disease | |
| JP2024065091A (en) | Compositions and methods for treating injuries and/or skin conditions | |
| CN1223355C (en) | Dermatitis treating ointment and its prepn | |
| CN1251674C (en) | Medication combinaton for treating skin disease and preparation technique | |
| CN1093896A (en) | Tonic cream for foot-xiangye jiezu cream and preparation method thereof | |
| CN1778373A (en) | Health-care composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: INJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMIS Free format text: FORMER OWNER: XINJIANG INST. OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES Effective date: 20031117 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20031117 Address after: 830011 No. 40 South Beijing Road, the Xinjiang Uygur Autonomous Region, Urumqi, attached 2 Applicant after: The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Scie Address before: 830011 No. 40 South Beijing Road, the Xinjiang Uygur Autonomous Region, Urumqi, attached 2 Applicant before: Xinjiang Institute of chemistry, Chinese Academy of Sciences |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |