CN115624628A - Preparation method of silicon dioxide drug sustained-release carrier with pore structure - Google Patents
Preparation method of silicon dioxide drug sustained-release carrier with pore structure Download PDFInfo
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- CN115624628A CN115624628A CN202211095615.8A CN202211095615A CN115624628A CN 115624628 A CN115624628 A CN 115624628A CN 202211095615 A CN202211095615 A CN 202211095615A CN 115624628 A CN115624628 A CN 115624628A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a silicon dioxide drug sustained-release carrier with a pore structure, and relates to the field of drug sustained-release carrier materials. The method comprises the following steps: 1. selecting proper adhesive and inert carrier material, and mixing or adhering; 2. preparing organic-inorganic hybrid particles 3 with good monodispersity by a suspension method, baking to remove water, preparing monodisperse unbonded powder particles 4, and removing template agent substances by high-temperature sintering to prepare carrier particles with adjustable pore structures, porosity, particle sizes and the like; 5. the carrier particles are surface modified to match the loading of different active ingredient substances. The preparation method is simple and reasonable, and the prepared carrier for drug slow release has good use effect, can ensure that the drug is slowly and uniformly released in a human body, and improves the safety of the drug use.
Description
Technical Field
The invention relates to the field of drug sustained-release carrier materials, in particular to a preparation method of a silicon dioxide drug sustained-release carrier with a pore structure.
Background
In recent years, particle design technology is often applied to the field of medicine, and is used for solving some common defects in traditional Chinese medicine production, such as poor flowability, strong hygroscopicity, low dissolution rate of active ingredients, unstable preparation, volatility, pungent smell and other pharmaceutical defects of compound preparations due to obvious property difference of medicinal materials and poor powder properties.
The particle design technology is classified into a structural particle design technology and a surface particle design technology according to different process forms. The design technology of the structural particles used in the traditional Chinese medicine preparation comprises an ultrafine grinding technology, particle mechanical compounding and the like. The surface particle design technology used in the traditional Chinese medicine preparation comprises a sol-gel method, a heterogeneous condensation method, a surface modification technology, a solvent volatilization method and the like. Under the current state of the art, the most commonly used particle design techniques for modifying Chinese medicinal powders are: superfine pulverizing technique, mechanical composition of particles, surface modifying technique and solvent volatilizing method.
The superfine grinding technology utilizes mechanical force to perform collision, friction, shearing and the like on powder particles to finish the wall breaking action of cells, and the grinding granularity of the powder particles is controlled in the micro powder range of less than 75 mu m. For base materials containing oil and volatile components, the superfine grinding technology can realize cell disruption at low temperature or in a cryogenic state, so that the maximum retention rate of unstable bioactive components is realized while other components are effectively dissolved. The superfine grinding technology realizes the cell-level grinding of the traditional Chinese medicine powder, achieves the micro-nano of the traditional Chinese medicine powder particles to the maximum extent, and has the wall-breaking rate as high as 95 percent.
The particle mechanical compounding is designed by classifying and modifying medicinal material particles on the basis of the physical and chemical properties of medicinal materials, regulating and controlling the feeding sequence, feeding proportion, compounding mode, compounding time and the like of the medicinal materials, orderly arranging the randomly dispersed and mixed traditional Chinese medicine powder, reducing the uncertainty of the powder particles and realizing the design of the specific structure and function of the medicinal material particles.
The particle mechanical composition completes the crushing of particle size by means of mechanical force, realizes the grading of particle size, wherein large particle size particles are used as mother ions as inner core particles in particle design, small particle size particles are used as outer shell particles in particle design, and the outer shell particles are converted into ultrafine particles in a high-activity state through the continuous action of mechanical force, intermolecular force and van der Waals force, and are gradually adsorbed, embedded and wrapped on the surfaces of the core particles.
The powder surface modification technology mainly utilizes the advantages of a surface modifier to carry out microencapsulation, micro-spheroidization and mechanical composite treatment on powder particles so as to realize coating, grafting, deposition and the like of the powder particles, and finally finishes surface modification, modification and property optimization of the powder particles [15].
In recent years, surface modification technology is often applied to the production and preparation of traditional Chinese medicine preparations to improve the characteristic indexes of wettability, fluidity, hygroscopicity and the like of powder materials in a prescription, and common modifiers include nanoparticles, surfactants, wetting agents, adhesives, dispersing agents, high polymer materials and the like.
Based on the action mechanism and modification advantages of the particle design technology, the solvent volatilization method can also adopt the guiding concept of 'medicine-assistant-in-one' according to the physicochemical properties of the traditional Chinese medicine powder, orderly wraps 2 or more medicinal material particles, carries out structural and functional design on the powder from a micro layer surface, and improves the performance of the powder, wherein the structural design comprises the particle shape, the composition proportion, the particle diameter, the particle size distribution, the surface characteristics, the smell, the taste and the like; functional design includes dispersion uniformity, moisture resistance, disintegration, flowability, sedimentation, stability of volatile components, solubilization of poorly soluble components, etc. [16].
The technology can effectively regulate and control the surface structure and function of the traditional Chinese medicine powder, overcome the defect of common pharmaceutics of the traditional Chinese medicine powder, and improve the preparation quality of the traditional Chinese medicine powder.
In conclusion, the invention designs a preparation method of the carrier with a pore structure for slow release of silicon dioxide drugs.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the preparation method of the silicon dioxide carrier for drug sustained release with a pore structure, the preparation method is simple and reasonable, the prepared carrier for drug sustained release has a good use effect, the drug can be slowly and uniformly released in a human body, and the use safety of the drug is improved.
In order to achieve the purpose, the invention is realized by the following technical scheme: a preparation method of a carrier with a pore structure for slow release of silicon dioxide drugs comprises the following steps:
1. selecting a proper adhesive and an inert carrier substance, and carrying out mixing processing or adhesion;
2. preparation of organic-inorganic hybrid particles with good monodispersity by using suspension method
3. Special drying process, baking to remove water, and preparing monodisperse non-adhesive powder particles
4. Removing template agent substances by high-temperature sintering to prepare carrier particles with adjustable pore structures, porosity, particle sizes and the like;
5. the carrier particles are surface modified to match the loading of different active ingredient substances.
The inert carrier materials are polyvinyl alcohol, silicon dioxide and the like.
The suspension method of the step 2 can be replaced by a micro-emulsion method and a hydrothermal method.
The void structure of the step 4 is a spherical void structure.
The invention has the beneficial effects that: the invention designs a spherical pore structure which is a hollow structure, the primary particles forming the spherical structure are nano-grade silicon dioxide, the porosity control is achieved by removing the template through sintering, the hollow structure is achieved by further using four-fluid control through spray drying, the shell thickness is controllable, the whole preparation method is simple and controllable,
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
The technical scheme adopted by the specific implementation mode is as follows: a preparation method of a carrier with a pore structure for slow release of silicon dioxide drugs comprises the following steps:
1. selecting proper adhesive and inert carrier material, and mixing or adhering;
2. preparation of organic-inorganic hybrid particles with good monodispersity by using suspension method
3. Special drying process, baking to remove water, and preparing monodisperse non-adhesive powder particles
4. Removing template agent substances by high-temperature sintering to prepare carrier particles with adjustable pore structures, porosity, particle sizes and the like;
5. the carrier particles are surface modified to match the loading of different active ingredient substances.
It is noted that the inert carrier material is polyvinyl alcohol, silica, etc.
It is noted that the suspension method of step 2 can be replaced by a microemulsion method and a hydrothermal method.
In addition, the void structure of step 4 is a spherical void structure.
The working principle of the specific embodiment is as follows: the micro-nano-scale pore and hollow inert spherical particles can adsorb and fill effective substances (medicine API, organic matters and the like) into the spherical particles to form a combined body. The combination can realize the effect of slow and uniform release (lasting for 24-48 hours) of effective components in human bodies.
The preparation method of the carrier for the slow release of the silicon dioxide drug with the pore structure is simple in preparation process, the spherical pore structure is obtained through preparation, the primary particles forming the spherical structure are nano-grade silicon dioxide, the porosity control is achieved by removing the template through sintering, the hollow structure is achieved by using four-fluid control through spray drying, and the shell thickness is controllable. The carrier particles are subjected to surface modification to match the filling of different effective substances, so that the slow release effect of the medicament is improved, the use safety of the medicament is improved, and the practicability is high.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (4)
1. A preparation method of a carrier with a pore structure for slow release of silicon dioxide drugs is characterized by comprising the following steps:
(1) Selecting a binder and an inert carrier substance, and carrying out mixing processing or binding;
(2) Preparing organic-inorganic hybrid particles with good monodispersity by adopting a suspension method;
(3) A special drying process, baking to remove water, and preparing monodisperse non-bonded powder particles;
(4) Removing the template agent substances by high-temperature sintering to prepare carrier particles with adjustable pore structures, porosity and particle sizes;
(5) The surface of the carrier particles is modified to match the loading of different active ingredient substances.
2. The method for preparing a carrier for sustained release of a drug containing silica having a pore structure according to claim 1, wherein the inert carrier material is polyvinyl alcohol or silica.
3. The method for preparing a carrier for sustained release of a silica drug with a pore structure according to claim 1, wherein the suspension method of step (2) can be replaced by a microemulsion method and a hydrothermal method.
4. The method for preparing a carrier for sustained release of a silica drug having a pore structure according to claim 1, wherein the pore structure of the step (4) is a spherical pore structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211095615.8A CN115624628A (en) | 2022-09-08 | 2022-09-08 | Preparation method of silicon dioxide drug sustained-release carrier with pore structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211095615.8A CN115624628A (en) | 2022-09-08 | 2022-09-08 | Preparation method of silicon dioxide drug sustained-release carrier with pore structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115624628A true CN115624628A (en) | 2023-01-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211095615.8A Withdrawn CN115624628A (en) | 2022-09-08 | 2022-09-08 | Preparation method of silicon dioxide drug sustained-release carrier with pore structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115624628A (en) |
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2022
- 2022-09-08 CN CN202211095615.8A patent/CN115624628A/en not_active Withdrawn
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Application publication date: 20230120 |