CN115610805A

CN115610805A - Sealing box for plastic ampoule

Info

Publication number: CN115610805A
Application number: CN202211200143.8A
Authority: CN
Inventors: 程园茹
Original assignee: Huaxiashengsheng Pharmaceutical Beijing Co ltd
Current assignee: Huaxiashengsheng Pharmaceutical Beijing Co ltd
Priority date: 2022-09-29
Filing date: 2022-09-29
Publication date: 2023-01-17

Abstract

The invention relates to the field of medicines, in particular to a sealing box for a plastic ampoule, which comprises a plurality of back plates and a plurality of ampoule bins, wherein the back plates are of an integrated structure, the joints of the adjacent back plates are provided with creases, the ampoule bins are rectangular concave bins, the edges of the ampoule bins are provided with fixing eaves, the front surfaces of the ampoule bins are provided with indicator tubes and color cards, the outer surfaces of the ampoule bins and the front surfaces of the back plates are covered with aluminum foils, the fixing eaves are detachably and fixedly connected with a bone sealing strip which is connected with the back plates through a binding way, and the back plates and the ampoule bins are combined into the sealing box; the invention uses the air impermeability of the aluminum foil to isolate the sealed box from oxygen, creates an oxygen-free storage environment for the ampoule bottle, and prevents oxygen from permeating into the medicine through the plastic bottle body of the ampoule bottle so as to lead the medicine to be oxidized and overdue; judging the time for taking out the ampoule bottle by comparing the indicator with the colorimetric card, and assisting in deducing the quality guarantee condition of the medicine; by arranging the antioxidant coating on the front surface of the back plate, the unused medicines can be put back into the sealed box again, and an oxygen-free storage environment is created again.

Description

Sealing box for plastic ampoule

Technical Field

The invention relates to the field of medicines, in particular to a sealing box for a plastic ampoule.

Background

At present, the ampoule is mainly divided into a glass ampoule and a plastic ampoule, the glass ampoule is easy to generate glass slag in the process of breaking off the nipple, the plastic ampoule can avoid the problem, but the plastic ampoule is relative, the plastic ampoule has higher oxygen permeability due to the characteristics of the material of the plastic ampoule, and after oxygen permeates the body of the plastic ampoule and permeates into the ampoule, the oxygen can be contacted with the medicine in the ampoule, and partial medicine can be oxidized to cause overdue, the plastic ampoule is generally stored in a paper or plastic storage box at present, and the problem of oxygen permeation of the plastic ampoule is solved.

Regarding the problem of oxygen permeability of plastics, an article published in the journal of the Chinese plastics, namely research on testing oxygen permeability of plastic pipes by a differential pressure method (article number: 1001-9278 (2021) 01-0073-05), shows that plastic materials with different structures all have oxygen permeability to a certain extent.

For the permeation of oxygen in ampoules, an oxygen indicator needs to be added into a dark part sealing box to observe the specific oxygen permeation situation, for this, the invention patent CN106841187B (published: 2019-06-04) in china discloses a rapid liquid oxygen indicator and a preparation method and application thereof, and the oxygen indicator comprises active black 5, klebsiella pneumoniae KL1, a liquid culture medium and distilled water, and can be used for detecting oxygen in a food sealing storage environment, detecting whether oxygen exists or not in a medical anaerobic environment, an anaerobic bacteria culture environment and other anaerobic operation environments and determining the oxygen concentration.

In order to prevent the oxidative failure of the medicines, the Chinese invention patent CN110371356A (published: 2019-10-25) discloses an easily-oxidized medicine vacuum packaging machine, a sealing device is arranged in the machine body of the packaging machine, and the medicines are stored in a vacuum state by sucking away air in a packaging bag, so that the oxidative deterioration of the medicines is avoided. The invention provides an anti-oxidation solution, namely, the medicine is in a vacuum environment and completely isolates air, which is the most common solution, but the mechanism comprises a plurality of parts and has a very complex structure, once the vacuum-packaged medicine is taken out, the medicine is immediately exposed in oxygen and needs to be used up as soon as possible, and if the medicine is used up at one time, the medicine is wasted.

In view of the above problems, the present invention provides a sealing box for a plastic ampoule to improve the storage environment of the plastic ampoule, so that the storage and transportation of the medicine are more convenient.

Disclosure of Invention

The technical problems to be solved by the invention are as follows: the utility model provides a seal box for plastic ampoule can completely cut off ampoule and outside oxygen, prevents that oxygen from passing through the plastics body infiltration entering medicine of ampoule, avoids medicine oxidation overdue, can take out the time of medicine by the record simultaneously, and the supplementary medicine situation of guaranteeing the quality of judging.

The invention provides the following technical scheme: a sealing box for plastic ampoules comprises a plurality of back plates and a plurality of ampoule bins; the back plates are rectangular thin sheets; the back plates are of an integrated structure, and creases are arranged at the joints of the adjacent back plates; rectangular fixed eaves are arranged at the edges of the ampoule bins, and the size of each fixed eaves is consistent with that of the back plate; the ampoule cabin is a plastic thin plate of which the outer surface is covered with an aluminum foil; the back plate is a plastic thin plate with the front surface covered with an aluminum foil; the fixed eaves are fixedly connected with the front surface of the back plate; each back plate and each ampoule bin are fixedly connected and combined into a sealing box.

As an implementation mode of the invention, a bone-attached sealing strip is arranged at the fixed connection part of the front surface of the back plate and the fixed eave; the backboard and the ampoule bin are detachably and fixedly connected through a bone-sticking sealing strip.

As an embodiment of the invention, the front surface of the ampoule cabin is also provided with an indicator tube; the indicator pipe is a transparent closed pipeline which is vertically arranged, the inner diameter of the indicator pipe is 0.5-0.8mm, and the wall thickness is 0.1mm; and an oxygen indicator is injected into the indicator pipe.

In one embodiment of the present invention, the indicator tube is made of polyvinyl chloride on the outside and is a waterproof and breathable film made of ePTFE expanded polytetrafluoroethylene on the inside.

In an embodiment of the present invention, a color chart is further disposed on a side of the indicator tube.

As an embodiment of the invention, the rear side of the sealing box is also provided with a hoop; the hoop is fixedly connected with the rear surface of the back plate; the hoop is an elastic curled strip.

As an embodiment of the present invention, a buckle is disposed on the rear surface of the back plate; the sealing box positioned at the outermost ring is detachably and fixedly connected with the hoop through a buckle.

As an embodiment of the present invention, the back plate front surface is further provided with an antioxidant coating; the antioxidant coating material is tea polyphenol.

As an embodiment of the invention, the fold is provided with a plurality of spindle-shaped tearing-assistant openings along the axial direction; the upper end and the lower end of the crease are provided with notches.

As an embodiment of the invention, an easy-to-tear label is arranged at the upper end of the fixed eave; and anti-slip strips are arranged on the surfaces of the easy-to-tear labels.

The invention has the following beneficial effects:

1. according to the invention, the aluminum foil covers the front surface of the back plate and the outer surface of the ampoule bin, and the sealing box is isolated from external oxygen by utilizing the impermeability of the aluminum foil, so that an oxygen-free storage environment is created for the ampoule, and oxygen is prevented from permeating into the medicine through the plastic bottle body of the ampoule so as to ensure that the medicine is oxidized and overdue.

2. According to the invention, the indicator tube is arranged on the front surface of the ampoule bin, the oxygen indicator is injected into the indicator tube, the colorimetric card is arranged on the side edge of the indicator tube, and the color of the oxygen indicator is compared with the colorimetric card, so that the time for taking out the ampoule can be displayed, and the quality guarantee condition of the medicine can be deduced in an auxiliary manner.

3. According to the invention, the antioxidant coating is arranged on the front surface of the back plate, the bone-sticking sealing strip is arranged between the front surface of the back plate and the fixing eave, so that the back plate and the ampoule bin can be detached, the unused medicine can be placed back into the sealing box for storage again, the oxygen filled in the sealing box is consumed through the antioxidant coating, an oxygen-free storage environment is created again, and the medicine is stored continuously.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic front side view of a seal cartridge of the present invention;

FIG. 2 is a rear side schematic view of the seal box of the present invention;

FIG. 3 is a front side view of the back plate of the present invention;

FIG. 4 is a rear side view of the back plate of the present invention;

FIG. 5 is a schematic front side view of an ampoule storage of the present invention;

FIG. 6 is a rear side schematic view of an ampoule storage of the present invention;

FIG. 7 is a schematic view of the seal cartridge of the present invention;

FIG. 8 is a schematic view of a ferrule of the present invention;

FIG. 9 is a schematic view of the overall package crimping of the present invention;

fig. 10 is a schematic drawing of the overall package of the present invention.

In the figure: the sealing box 1, the hoop 2, the back plate 11, the fold 111, the buckle 112, the antioxidant coating 113, the ampoule bin 12, the fixing brim 121, the indicator tube 122, the easy-to-tear label 123, the color chart 124 and the bone sealing strip 13.

Detailed Description

In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.

Referring to fig. 1 to 10, the present invention discloses a sealing box for plastic ampoules, which comprises a plurality of back plates 11 and a plurality of ampoule bins 12; the back plates 11 are rectangular thin plates; the back plates 11 are of an integrated structure, and creases 111 are arranged at the joints of the adjacent back plates 11; rectangular fixed eaves 121 are arranged at the edges of the ampoule bins 12, and the size of each fixed eaves 121 is consistent with that of the back plate 11; the shape of the ampoule bin 12 can be designed by pasting a specific ampoule, so that the volume can be reduced as much as possible, the shake of the ampoule in the ampoule bin 12 can be reduced, and for a plastic ampoule with low storage requirement, the shape of the ampoule bin 12 can be designed into a rectangle and a circle, so that the ampoule bin is convenient to process and manufacture;

the ampoule bin 12 is a plastic thin plate with the outer surface covered with an aluminum foil; the back plate 11 is a plastic thin plate with the front surface covered with an aluminum foil; the aluminum foil has difficult air permeability, can isolate external oxygen and prevent the oxygen from entering the ampoule bin 12 to cause the oxygen to permeate the ampoule so as to cause the medicine to deteriorate; the materials of the ampoule cabin 12 and the back plate 11 are not fixed, any material can be used as the materials of the ampoule cabin 12 and the back plate 11 as long as the material meets the conditions of oxygen isolation, no toxicity and low price, and the packaging selection material of the medicine with the light-shielding storage requirement also needs to have light-tightness; the fixed eaves 121 are fixedly connected with the front surface of the back plate 11; each back plate 11 and each ampoule bin 12 are fixedly connected and combined to form a sealing box 1, and ampoules are stored in the sealing box 1 in an oxygen-free environment in a sealed mode.

Referring to fig. 1 and 2, a bone-attaching sealing strip 13 is arranged at the fixed connection position of the front surface of the back plate 11 and the fixed eave 121; the back plate 11 is detachably and fixedly connected with the ampoule bin 12 through a bone-sticking sealing strip 13; the bone-sticking sealing strip 13 can keep the air tightness of the sealing box 1, if the ampoule taken out of the sealing box 1 cannot be used up at one time, the ampoule can be put back into the sealing box 1 for storage, and the back plate 11 and the ampoule bin 12 can still be sealed and stuck through the bone-sticking sealing strip 13;

the width and the cross-sectional structure of the bone sealing strip 13 should be adapted to the size of the sealing box 1, if the size of the sealing box 1 is large, the width of the bone sealing strip should be increased, and the cross-sectional complexity is increased, so as to ensure the firmness of the attachment of the back plate 11 and the ampoule bin 12.

Referring to fig. 5, the front surface of ampoule chamber 12 is further provided with an indicator tube 122; the indicator pipe 122 is a transparent closed pipeline which is vertically arranged, the inner diameter of the indicator pipe 122 is 0.5-0.8mm, and the wall thickness is 0.1mm; too large or too small a volume of the indicator tube 122 may result in too much filling amount of the oxygen indicator to cause waste or too little oxygen indicator to cause color to be difficult to see, and the wall thickness of the indicator tube 122 may also have a certain effect on observing the color of the oxygen indicator; on the rectangular round ampoule bin 12, the shape of the indicator tube 122 is a long strip, and for some ampoule bins 12 with special shapes, the shape of the indicator tube 122 can be correspondingly designed, for example, the curvature change of the surface of the ampoule bin 12 is complex, the indicator tube 122 can be designed to be round and placed in a relatively flat area, even if the indicator tube 122 is arranged on the back plate 11, the design of the indicator tube 122 needs to facilitate the observation of the color of the oxygen indicator;

an oxygen indicator is injected into the indicator tube 122; when the sealing box 1 is opened to take out the ampoule, the oxygen indicator is simultaneously contacted with oxygen, the color begins to change, the time for taking out the ampoule can be deduced according to the change of the color of the oxygen indicator, and then whether the medicine in the ampoule is overdue or not can be judged; the oxygen indicator can reflect whether the sealing box 1 is completely closed; the shelf life of different drugs exposed to oxygen varies, and the oxygen indicator is selected and configured to be specific to the drug, and the time span of color change is about the same as the shelf life of the drug.

Referring to fig. 5, the indicator tube 122 is made of polyvinyl chloride on the outside and is a waterproof and breathable film made of ePTFE expanded polytetrafluoroethylene on the inside; the polyvinyl chloride material on the outer side of the indicator tube 122 is transparent, nontoxic and oxygen-insulating, so that the color change of the oxygen indicator can be observed conveniently, the oxygen indicator can be prevented from contacting oxygen outside the sealing box 1, and other transparent, nontoxic and oxygen-insulating materials can be used as the material of the indicator tube 122; the indicator tube 122 is bonded with the ampoule bin 12 through oxygen-isolating glue; a color comparison card 124 is arranged on the side edge of the indicator tube 122, and for different types of oxygen indicators, the color provided by the color comparison card 124 needs to be adjusted correspondingly; by comparing the color of the oxygen indicator with the color comparison card, the medicine taking time and the quality guarantee condition can be more conveniently and accurately inferred.

Referring to fig. 8-10, the rear side of the sealing box 1 is also provided with a hoop 2; the hoop 2 is fixedly connected with the rear surface of the back plate 11; the hoop 2 is an elastic curled strip; when the sealing box 1 is in a general storage state, the hoop 2 is in a curling state, and the plurality of sealing boxes 1 form a polygonal cylinder under the constraint of the hoop 2; when the sealing boxes 1 are taken, the hoop rings 2 can be straightened and kept in a straightened state, the sealing boxes 1 on the outermost side can be taken conveniently, after the taking is finished, the hoop rings 2 can be folded lightly to restore the hoop rings 2 to a bent state, and the sealing boxes 1 enclose a column body, so that the occupied space is reduced, and the storage and the transportation are convenient; the back surface of the back plate 11 is provided with a buckle 112; the sealing box 1 positioned at the outermost ring is detachably and fixedly connected with the hoop 2 through a buckle 112; the used ampoule and the corresponding sealing box 1 can be detached from the hoop 2, and the whole volume is reduced.

Referring to fig. 3, the front surface of the back plate 11 is further provided with an antioxidant coating 113; when the ampoule in the bottle is not used up, the ampoule is put back into the sealing box 1, and the sealing box 1 is filled with oxygen because the ampoule is opened, and the anti-oxidation coating can consume the oxygen in the sealing box 1 at the moment, so that the oxygen is prevented from oxidizing the medicine; the antioxidant coating 113 is made of tea polyphenol which is low in price and is a natural extraction material, so that toxicity is avoided; besides tea polyphenols, other antioxidants can be used as the material of the antioxidant coating, such as natural antioxidant phytic acid, synthetic antioxidants BHA, BHT, PG, etc.

Referring to fig. 7, a plurality of spindle-shaped tearing-assistant openings are formed in the crease 111 along the axial direction; notches are arranged at the upper end and the lower end of the crease 111; the adjacent back boards 11 can be torn along the crease 111, and the notches and the tearing-assistant openings enable the crease 111 to have high tensile strength and be easy to cut, so that the back boards 11 can be prevented from being torn when the back boards 11 are torn off, and the air tightness of the sealing box 1 is reduced; the upper end of the fixed eave 121 is provided with an easy-to-tear label 123; the back plate 11 and the ampoule bin 12 can be more conveniently detached by lifting and pulling the easy-tear label 123; the surface of the easy-to-tear label 123 is provided with an anti-slip strip; the cleats increase the friction when pulling the peel off label 123.

When the ampoule storage box is used, the hoop 2 is firstly straightened, the ampoule bin 12 located on the outermost side is detached from the back plate 11 by lifting the easy-tear label 123, an ampoule in the sealing box 1 is taken out for use, when the sealing box 1 is opened, oxygen enters the ampoule bin 12, the oxygen indicator contacts with the waterproof breathable film, the color of the oxygen indicator changes along with time and can be observed through the transparent indicator tube 122, the length of time that the ampoule has been taken out can be deduced by comparing the colorimetric cards, and then the quality guarantee condition of the medicine in the ampoule is judged.

If the medicine in the ampoule is not used up once and is not overdue, the ampoule can be placed back into the sealed box 1 again, the edge of the fixing brim 121 and the edge of the back plate 11 are kneaded, the bone-attached sealing strip 13 is clamped in a sealing mode again, oxygen is filled in the sealed box 1 at the moment, the oxygen in the sealed box 1 can be consumed by the antioxidant coating 113, the medicine in the ampoule is prevented from being oxidized by the oxygen and deteriorating, and meanwhile, the color change of the oxygen indicator is stopped due to the fact that the inside of the sealed box 1 is restored to the oxygen-free environment.

When the medicine in the ampoule is completely used up or overdue, the ampoule and the corresponding sealing box 1 can be taken down from the hoop 2 and discarded, the hoop 2 is folded slightly to restore the curling state, and the hoop 2 drives the remaining sealing boxes 1 to enclose into a cylinder, so that the occupied area is reduced, and the storage and the transportation are convenient.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides a seal box for plastics ampoule which characterized in that: comprises a plurality of back plates (11) and a plurality of ampoule bins (12); the back plates (11) are rectangular thin sheets; the back plates (11) are of an integrated structure, and creases (111) are arranged at the joints of the adjacent back plates (11); rectangular fixed eaves (121) are arranged at the edges of the ampoule bins (12), and the size of each fixed eaves (121) is consistent with that of the back plate (11); the ampoule cabin (12) is a plastic thin plate with the outer surface covered with an aluminum foil; the back plate (11) is a plastic thin plate with the front surface covered with an aluminum foil; the fixed eave (121) is fixedly connected with the front surface of the back plate (11); each back plate (11) and each ampoule bin (12) are fixedly connected and combined into a sealing box (1).

2. The sealing case for plastic ampoules according to claim 1, wherein: a bone-attached sealing strip (13) is arranged at the fixed connection part of the front surface of the back plate (11) and the fixed eave (121); the back plate (11) is detachably and fixedly connected with the ampoule bin (12) through a bone-sticking sealing strip (13).

3. The sealing case for plastic ampoules according to claim 1, wherein: an indicator tube (122) is further arranged on the front surface of the ampoule cabin (12); the indicator pipe (122) is a transparent closed pipeline which is vertically arranged, the inner diameter of the indicator pipe (122) is 0.5-0.8mm, and the wall thickness is 0.1mm; an oxygen indicator is injected into the indicator tube (122).

4. The sealing case for plastic ampoules according to claim 3, wherein: the outer side of the indicator tube (122) is made of polyvinyl chloride, and the inner side of the indicator tube is a waterproof breathable film made of ePTFE (expanded polytetrafluoroethylene).

5. The sealing case for plastic ampoules according to claim 3, wherein: a color comparison card (124) is arranged on the side edge of the indicator tube (122).

6. The sealing case for plastic ampoules according to claim 1, wherein: a hoop (2) is arranged on the rear side of the sealing box (1); the hoop (2) is fixedly connected with the rear surface of the back plate (11); the hoop (2) is an elastic curling strip.

7. The sealing case for plastic ampoules according to claim 6, wherein: the rear surface of the back plate (11) is provided with a buckle (112); the sealing box (1) positioned at the outermost ring is detachably and fixedly connected with the hoop (2) through a buckle (112).

8. The sealing case for plastic ampoules according to claim 1, wherein: the front surface of the back plate (11) is also provided with an antioxidant coating (113); the antioxidant coating (113) is made of tea polyphenol.

9. The sealing case for plastic ampoules according to claim 1, wherein: the crease (111) is provided with a plurality of fusiform tearing-assistant openings along the axial direction; notches are arranged at the upper end and the lower end of the crease (111).

10. The sealing case for plastic ampoules according to claim 1, wherein: an easily-torn label (123) is arranged at the upper end of the fixed eave (121); and the surface of the easy-to-tear label (123) is provided with an anti-slip strip.