CN115608181B - Mixing and dissolving device and wet granulation method - Google Patents

Abstract

The invention provides a mixing and dissolving device and a wet granulation method, and belongs to the technical field of mixing and stirring equipment. The device comprises a mixing kettle, a flow guide cover, a power assembly, a stirring paddle and a rolling assembly, wherein the flow guide cover is of a conical structure and is buckled in the mixing kettle, the upper part of the flow guide cover is provided with an overflow port, an overflowing channel is arranged between the lower part of the flow guide cover and the bottom of the mixing kettle, and the inner side of the flow guide cover is provided with a heater; the power assembly is arranged on the mixing kettle and is provided with a power shaft, and the power shaft extends into the mixing kettle and penetrates through the overflow port; the stirring paddle is arranged at the lower part of the mixing kettle and is connected with the power shaft; the rolling component is arranged in the overflow port and is connected with the power shaft. The method comprises the step of mixing and dissolving the raw materials by adopting the mixing and dissolving device. The invention does not need to adopt a high-power high-speed stirrer, can improve the production safety, reduce noise pollution, reduce the abrasion of equipment, save a large amount of energy, reduce energy consumption, and is more energy-saving and environment-friendly.

Description

Mixing and dissolving device and wet granulation method

Technical Field

The invention belongs to the technical field of mixing and stirring equipment, and particularly relates to a mixing and dissolving device and a wet granulation method.

Background

In the process of pharmacy or other industrial production, starch paste raw materials are often needed, the existing method for preparing the starch paste mainly utilizes a pulping pot to prepare the starch, a stirrer is used for strong stirring to form starch suspension during preparation, and then the pulping pot is heated to prepare the starch paste.

However, the method has high energy consumption, noise, environmental friendliness and high production cost, and is difficult to expand the production scale. Firstly, the pulping pot is basically externally heated, the heat dissipation is serious, and the energy utilization rate is low; secondly, the starch is very easy to agglomerate after being pressed or moistened, and the starch agglomeration phenomenon is also easy to generate when the starch is mixed with an adhesive (water), so that the starch liquid has agglomeration and particles which are not easy to mix uniformly, so that the starch needs to be fully crushed before starch pulping, a filter screen is also needed to be arranged at a discharging part to filter the agglomeration and the particles if necessary, so as to avoid influencing the subsequent product quality, not only increasing the working procedure and energy consumption, but also easily introducing impurities such as scrap iron and the like when crushing and grinding are carried out, and the filter is not timely treated and is easy to generate pollution; moreover, due to the starch agglomeration, the starch agglomeration can be substantially eliminated by sufficiently stirring with a high-power stirrer during stirring, the high-power stirrer not only consumes a large amount of electricity during operation, is dangerous to operate, but also generates noise, and is easy to wear during strong friction with liquid, so that metal substances are dispersed into the starch liquid, and the size of the pulping pot is limited under the limitation of the rotating speed and the material strength of the high-power stirrer, so that the pulping pot is difficult to be made large, otherwise, the stirring is not uniform.

Disclosure of Invention

The invention aims to provide a mixing and dissolving device and a wet granulation method, which are used for solving the technical problems of high energy consumption and environmental pollution of starch paste raw materials in the pulping process in the prior art.

In order to realize the purpose, the invention adopts the technical scheme that: the utility model provides a mixing and dissolving device, which comprises a mixing kettle, a flow guide cover, a power component, a stirring paddle and a rolling component, wherein the flow guide cover is in a conical structure and is buckled in the mixing kettle, the upper part of the flow guide cover is provided with an overflow port, an overflowing channel is arranged between the lower part of the flow guide cover and the bottom of the mixing kettle, and the inner side of the flow guide cover is provided with a heater for heating the liquid in the mixing kettle; the power assembly is arranged on the mixing kettle and is provided with a power shaft, and the power shaft extends into the mixing kettle and penetrates through the overflow port to provide rotary power; the stirring paddle is arranged at the lower part of the mixing kettle, is connected with the power shaft, and is used for rotating under the driving of the power shaft so as to stir the liquid in the mixing kettle and push the liquid in the air guide sleeve to the outside of the air guide sleeve through the overflowing channel; the rolling component is arranged in the overflow port and is connected with the power shaft for rolling away particles in the liquid.

In a possible implementation mode, the rolling component comprises a filter screen and a pressing plate, the filter screen is arranged below an overflow port of the air guide sleeve, and the pressing plate is located above the filter screen and connected with the power shaft at one end so as to roll particles on the filter screen under the driving of the power shaft.

In one possible implementation mode, an overflow adjusting pipe is arranged on the overflow port, the overflow adjusting pipe is connected with the overflow port in a sliding and sealing mode along the vertical direction and used for adjusting the height of overflow, a filter screen is arranged in the overflow adjusting pipe, and a power shaft penetrates through the overflow adjusting pipe and the filter screen; the pressure plate is arranged on the power shaft in a vertical sliding manner.

In a possible implementation mode, the filter screen is arranged in the overflow adjusting pipe in an inward inclined mode, the height of the filter screen gradually rises in the direction from the inner wall of the overflow adjusting pipe to the power shaft, and the angle of the pressing plate is matched with the angle of the filter screen.

In one possible implementation mode, the pressure plate is connected with the power shaft in a sliding mode through a sliding sleeve, the pressure plate is connected with the sliding sleeve in a rotating mode, and the rotating shaft is perpendicular to the power shaft; the pressure plate is provided with a first magnet,

a plurality of second magnets are distributed on the filter screen, and the first magnets and the second magnets are arranged in a repelling manner; one side of clamp plate towards the filter screen is equipped with the holding tank.

In a possible implementation mode, a traction adjusting component is arranged on the overflow adjusting pipe and used for adjusting the height of the overflow adjusting pipe; the traction adjusting assembly comprises a traction rod, one end of the traction rod is connected with the overflow adjusting pipe, and the other end of the traction rod extends to the outside of the mixing kettle, or the traction adjusting assembly comprises a floating ball which is arranged at the lower part of the overflow adjusting pipe.

In a possible implementation mode, the mixing and dissolving device further comprises a feeding assembly, a spraying assembly and a discharging assembly, wherein the feeding assembly and the spraying assembly are arranged at the upper part of the mixing kettle and are respectively used for feeding powder and liquid materials, the discharging assembly is arranged at the lower part of the mixing kettle, and the spraying assembly faces towards the inner wall of the mixing kettle and the outer wall of the flow guide cover; the mixing kettle is of a sealing structure, and a negative pressure assembly is arranged on the mixing kettle and is used for forming a negative pressure environment in the mixing kettle; the guide cover is provided with a vibrator; the air guide sleeve is fixedly connected with the mixing kettle through a plurality of support rods, and the support rods are elastic rods.

In a possible implementation mode, the stirring paddle comprises an inner stirring portion, a material pushing portion and an outer stirring portion, the inner stirring portion is located in the air guide sleeve and connected with the power shaft and used for stirring materials in the air guide sleeve, the material pushing portion is connected with the outer end of the inner stirring portion and located below the lower edge of the air guide sleeve and used for pushing liquid in the air guide sleeve to the outside of the air guide sleeve from the overflowing channel, and the outer stirring portion is connected with the outer end of the material pushing portion and used for driving the liquid outside the air guide sleeve to rotate.

The mixing and dissolving device provided by the invention has the beneficial effects that: compared with the prior art, the invention ensures that the liquid in the mixing kettle is continuously circulated between the inside and the outside of the air guide sleeve under the action of the stirring blade through the matching of the mixing kettle, the air guide sleeve, the power component, the stirring blade and the rolling component, so that the starch in the starch is agglomerated and overflows to the rolling component through the overflow port to be rolled, and the starch is fully dissolved and mixed in the liquid, thereby ensuring that the mixing process is mainly carried out in low-speed flow, and the starch is softer without adopting a high-power high-speed stirrer or excessively high requirement on the prior crushing, not only improving the production safety and reducing the noise pollution, but also reducing the abrasion of equipment, and reducing the energy consumption; and then the liquid is heated by the heater positioned on the inner side of the air guide sleeve, so that the starch is heated and gelatinized from inside to outside, the heat dissipation can be reduced, a large amount of energy can be saved, the energy consumption is reduced, and the starch heating device is more energy-saving and environment-friendly.

In order to realize the purpose, the invention adopts the following technical scheme: there is provided a wet granulation process comprising the steps of:

the raw materials are mixed and dissolved by adopting the mixing and dissolving device.

In one possible implementation, the method further includes the following steps:

A. crushing, namely crushing the medicine raw materials into powder;

B. pulping, namely mixing and dissolving starch and water in a mixing and dissolving device to form starch slurry;

C. granulating, namely mixing the medicine raw materials which are crushed into powder in the step A and the starch slurry formed in the step B by adopting a wet granulator to prepare granules;

D. drying, drying the granules prepared in the step C;

E. and D, preparing the dried granules in the step D into granules, tablets or capsules according to the required dosage form, and packaging.

The wet granulation method provided by the invention has the beneficial effects that: compared with the prior art, the raw materials are mixed and dissolved by adopting the mixing and dissolving device, so that the mixing process is mainly carried out in low-speed flow, the mixing process is softer, a high-power high-speed stirrer is not required to be adopted, the requirement on the prior crushing is not required to be too high, the production safety can be improved, the noise pollution is reduced, the abrasion of equipment is reduced, and the energy consumption can be reduced; and then the liquid is heated by the heater positioned on the inner side of the air guide sleeve, so that the heating gelatinization of the starch is carried out from inside to outside, the heat dissipation can be reduced, a large amount of energy can be saved, the energy consumption is reduced, and the energy-saving and environment-friendly effects are achieved.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.

FIG. 1 is an external view of a mixing and dissolving apparatus according to an embodiment of the present invention;

fig. 2 is a schematic view of an internal structure of a mixing and dissolving apparatus according to an embodiment of the present invention;

FIG. 3 is a schematic cross-sectional view of a mixing and dissolving apparatus according to an embodiment of the present invention;

FIG. 4 is an enlarged schematic view of the mixing and dissolving device shown in FIG. 3 at A;

fig. 5 is a schematic diagram of a wet granulation process provided by an embodiment of the present invention.

Wherein, each reference number in the figures is as follows:

10. a mixing kettle;

20. a pod; 21. an overflow port; 22. an overflow channel;

23. an overflow regulating pipe; 24. a support bar; 25. a vibrator; 26. a heater;

30. a power assembly; 31. a power shaft;

40. a stirring paddle; 41. an inner stirring section; 42. a material pushing section; 43. an outer stirring section;

50. rolling the component; 51. filtering with a screen; 52. pressing a plate;

53. a sliding sleeve; 54. a first magnet; 55. a second magnet; 56. accommodating grooves;

60. a feeding assembly; 70. a spray assembly; 80. a discharging assembly; 90. and a negative pressure assembly.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.

It should be further understood that the drawings and embodiments of the present invention mainly describe the concept of the present invention, and on the basis of the concept, the specific forms and arrangements of some connection relationships, position relationships, power mechanisms, power supply systems, hydraulic systems, control systems, etc. may not be completely described, but those skilled in the art can implement the specific forms and arrangements in a known manner on the premise that those skilled in the art understand the concept of the present invention.

When an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

The terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship indicated in the drawings for convenience in describing the invention and to simplify the description, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and is therefore not to be construed as limiting the invention.

The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more, and "several" means one or more unless specifically limited otherwise.

The mixing and dissolving apparatus and the wet granulation method according to the present invention will now be described.

Referring to fig. 1 to 4, a mixing and dissolving apparatus according to a first embodiment of the present invention includes a mixing kettle 10, a diversion cover 20, a power assembly 30, a stirring blade 40 and a rolling assembly 50, wherein the diversion cover 20 is a tapered structure and is fastened in the mixing kettle 10, an overflow port 21 is disposed at an upper portion of the diversion cover 20, an overflow channel 22 is disposed between a lower portion of the diversion cover and a bottom of the mixing kettle 10, and a heater 26 is disposed at an inner side of the diversion cover for heating liquid inside; the power assembly 30 is arranged on the mixing kettle 10 and is provided with a power shaft 31, and the power shaft 31 extends into the mixing kettle 10 and penetrates through the overflow port 21 to provide rotary power; the stirring paddle 40 is arranged at the lower part of the mixing kettle 10, is connected with the power shaft 31, and is used for rotating under the driving of the power shaft 31 so as to stir the liquid in the mixing kettle 10 and push the liquid in the air guide sleeve 20 to the outside of the air guide sleeve 20 through the overflowing channel 22; a crushing assembly 50 is provided in the overflow 21 and is connected to the power shaft 31 for crushing particles in the liquid.

When pulping is carried out, firstly, feeding materials into the mixing kettle 10, opening the power assembly 30 to drive the stirring blade 40 and the rolling assembly 50 to move, wherein the stirring blade 40 pushes the liquid inside the air guide sleeve 20 to the outside of the air guide sleeve 20 through the overflow channel 22, so that a liquid level difference is generated between the inside and the outside of the air guide sleeve 20, and further the liquid outside the air guide sleeve 20 overflows at the overflow port 21 of the air guide sleeve 20, and the starch agglomerates in the liquid contain gas and are cone-shaped, so that the starch agglomerates outside the air guide sleeve 20 gradually float upwards to the liquid surface as the liquid moves more slowly, overflow to the rolling assembly 50 below the overflow port 21, are rolled by the rolling assembly 50, are dissolved under the washing of the overflow above and continuously enter the inside of the air guide sleeve 20, and continuously circulate in the above way until the starch agglomerates basically disappear, then, the heater 26 inside the air guide sleeve 20 is started to heat the liquid, so that the temperature reaches a reasonable range, and starch paste is formed.

Compared with the prior art, the mixing and dissolving device provided by the embodiment has the advantages that through the cooperation of the mixing kettle 10, the air guide sleeve 20, the power assembly 30, the stirring paddle 40 and the rolling assembly 50, liquid in the mixing kettle 10 is enabled to continuously circulate between the inside and the outside of the air guide sleeve 20 under the action of the stirring paddle 40, starch in the liquid is agglomerated and overflows to the rolling assembly 50 through the overflow port 21 to be rolled open, so that the starch is fully dissolved and mixed in the liquid, the mixing process is mainly carried out in low-speed flow, the mixing device is softer, a high-power high-speed stirrer is not needed, the requirement on pre-crushing is not high, the production safety can be improved, the noise pollution is reduced, the equipment abrasion is reduced, and the energy consumption can be reduced to some extent; then, the liquid is heated by the heater 26 positioned on the inner side of the air guide sleeve 20, so that starch is heated and gelatinized from inside to outside, the heat dissipation can be reduced, a large amount of energy can be saved, the energy consumption is reduced, and the energy-saving and environment-friendly effects are achieved.

Referring to fig. 1 to fig. 4, a first embodiment of the present invention is further provided as follows:

the rolling component 50 comprises a filter screen 51 and a pressing plate 52, the filter screen 51 is arranged below the overflow port 21 of the flow guide cover 20, the pressing plate 52 is arranged above the filter screen 51, and one end of the pressing plate is connected with the power shaft 31 so as to roll particles on the filter screen 51 under the driving of the power shaft 31. The overflow port 21 is provided with a flow guiding brim for preventing the liquid flowing down from the overflow port 21 from flowing along the inner wall of the flow guiding cover 20, and the liquid flowing down from the overflow port 21 falls on the filter screen 51.

Referring to fig. 3 and fig. 4, a first embodiment of the present invention is further provided as follows:

an overflow adjusting pipe 23 is arranged on the overflow port 21, the overflow adjusting pipe 23 is in sliding sealing connection with the overflow port 21 along the vertical direction and is used for adjusting the height of overflow, a filter screen 51 is arranged in the overflow adjusting pipe 23, and the power shaft 31 penetrates through the overflow adjusting pipe 23 and the filter screen 51; the pressure plate 52 is vertically slidably disposed on the power shaft 31.

The filter screen 51 is arranged in the overflow adjusting pipe 23 in an inward inclined manner, the height of the filter screen gradually rises in the direction from the inner wall of the overflow adjusting pipe 23 to the power shaft 31, and the angle of the pressure plate 52 is matched with that of the filter screen 51.

The pressure plate 52 is connected with the power shaft 31 in a sliding manner through a sliding sleeve 53, the pressure plate 52 is connected with the sliding sleeve 53 in a rotating manner, and the rotating shaft is vertical to the power shaft 31; the pressing plate 52 is provided with a first magnet 54, the filter screen 51 is distributed with a plurality of second magnets 55, and the first magnet 54 and the second magnets 55 are arranged in a repelling manner, so that the pressing plate 52 can be just suspended on the filter screen 51, the friction between the pressing plate 52 and the filter screen 51 is avoided, the service life of the filter screen 51 is prolonged, and the possibility of generating metal debris is reduced; the side of the pressure plate 52 facing the sieve 51 is provided with a receiving groove 56 for receiving magnetically attracted metal particles.

And a traction adjusting component is arranged on the overflow adjusting pipe 23 and is used for adjusting the height of the overflow adjusting pipe 23.

The traction adjusting assembly comprises a traction rod, one end of the traction rod is connected with the overflow adjusting pipe 23, the other end of the traction rod extends to the outside of the mixing kettle 10, and the height of the overflow adjusting pipe 23 is adjusted outside the mixing kettle 10 through driving the traction rod.

Or, the traction adjusting component comprises a floating ball which is arranged at the lower part of the overflow adjusting pipe 23 so as to drive the overflow adjusting pipe 23 to move up and down through buoyancy and gravity.

The mixing and dissolving device further comprises a feeding assembly 60, a spraying assembly 70 and a discharging assembly 80, wherein the feeding assembly 60 and the spraying assembly 70 are arranged on the upper portion of the mixing kettle 10 and are respectively used for feeding powder and liquid materials, the discharging assembly 80 is arranged on the lower portion of the mixing kettle 10, and the spraying assembly 70 faces the inner wall of the mixing kettle 10 and the outer wall of the air guide sleeve 20, so that the materials adhered to the upper portion can be washed away when the materials are fed, and meanwhile, the cleaning is facilitated.

Mixing kettle 10 is seal structure, is equipped with negative pressure subassembly 90 on the mixing kettle 10 for make and form negative pressure environment in the mixing kettle 10, so that reduce the atmospheric pressure in the mixing kettle 10, make the granule in the liquid float more easily, and contain less air in making the liquid, the leading-in of the material of can being convenient for simultaneously.

When using, in order to avoid too much starch conglomeration to be located mixing kettle 10, utilize negative pressure subassembly 90 to pressure boost in the mixing kettle 10 earlier, make starch conglomeration volume compression, can flow to the kuppe 20 outside under stirring paddle 40's effect, later recycle negative pressure subassembly 90 to mixing kettle 10 decompression, form the negative pressure, make starch conglomeration volume increase and come-up, thereby the overflow gets into rolling subassembly 50 and is rolled out, if there is starch conglomeration in the kuppe 20, can repeat above-mentioned step.

The vibration device 25 is arranged on the air guide sleeve 20 to drive the air guide sleeve 20 to vibrate, so that the adhesion of materials is reduced; kuppe 20 is connected fixedly through a plurality of bracing pieces 24 with mixing cauldron 10, and bracing piece 24 is the elastic rod to carry out the shock attenuation, avoid too much vibrations to transmit to mixing cauldron 10 from kuppe 20 on, produce too big noise.

The stirring paddle 40 comprises an inner stirring portion 41, a pushing portion 42 and an outer stirring portion 43, the inner stirring portion 41 is located in the air guide sleeve 20 and connected with the power shaft 31 and used for stirring materials in the air guide sleeve 20, the pushing portion 42 is connected with the outer end of the inner stirring portion 41 and located below the lower edge of the air guide sleeve 20 and used for pushing liquid in the air guide sleeve 20 to the outside of the air guide sleeve 20 from the overflowing channel 22, and the outer stirring portion 43 is connected with the outer end of the pushing portion 42 and used for driving the liquid outside the air guide sleeve 20 to rotate.

Referring to fig. 5, a wet granulation method according to a second embodiment of the present invention includes the following steps:

the raw materials are mixed and dissolved by adopting the mixing and dissolving device.

Compared with the prior art, the wet granulation method provided by the embodiment has the advantages that the raw materials are mixed and dissolved by adopting the mixing and dissolving device, so that the mixing process is mainly carried out in low-speed flow, the mixing is softer, a high-power high-speed stirrer is not required, the requirement on the prior crushing is not high, the production safety can be improved, the noise pollution is reduced, the equipment abrasion is reduced, and the energy consumption is reduced; then, the liquid is heated by the heater 26 positioned on the inner side of the air guide sleeve 20, so that starch is heated and gelatinized from inside to outside, the heat dissipation can be reduced, a large amount of energy can be saved, the energy consumption is reduced, and the energy-saving and environment-friendly effects are achieved.

The invention further provides a specific implementation mode based on the second implementation mode, which comprises the following steps:

the wet granulation process further comprises the steps of:

A. crushing, namely crushing the medicine raw materials into powder;

B. pulping, namely mixing and dissolving starch and water in a mixing and dissolving device to form starch slurry;

C. granulating, namely mixing the medicine raw materials crushed into powder in the step A and the starch slurry formed in the step B by adopting a wet granulator to prepare granules;

D. drying, drying the granules prepared in the step C;

E. and D, preparing the dried granules in the step D into granules, tablets or capsules according to the required dosage form, and packaging.

Specifically, a specific embodiment is exemplified below.

1. Pre-processing (granulation) procedure

(1) Pulverizing

And raw and auxiliary materials are taken from a storehouse according to a production instruction and enter a raw and auxiliary material temporary storage chamber through a material inlet, a buffer room and a bag removal. The materials are crushed and sieved according to the prescription requirement, and the sieving machine set utilizes the relative motion between the movable fluted disc and the fixed fluted disc to crush the materials through tooth impact, friction and mutual impact of the materials. The crushed materials automatically enter the trapping bag under the action of the rotary centrifugal force. And screening the mixture and then feeding the mixture into a material turnover barrel. And weighing and calculating the turnover barrel according to the prescription to complete the batching.

(2) Preparation of

Firstly, fully stirring weighed starch by the mixing and dissolving device to prepare 10% starch paste for later use, wherein the 10% starch paste is a paste prepared by heating starch liquid with the starch content of 10%, and mainly has an adhesion effect.

(3) Granulating

The method is characterized in that wet granulation is adopted, weighed raw material medicines and dry starch are conveyed to a granulation chamber in a closed mode through a material transfer cart, the raw material medicines and the dry starch are conveyed to a wet granulator through a full-automatic feeding machine, the wet granulation adopts the principle of high-speed flowing and cutting granulation, and 10% of starch paste is added and stirred. The operation took 8 minutes per pot. The principle is as follows: in the material pot, due to the rotary motion of the main stirring paddle, the material circularly moves in the pot, moves towards the pot wall along the paddle, then rises and falls. Thereby forming a parabolic revolution and billowing motion. The granulating cutter rotates at high speed in the flowing area of the revolution motion of the materials, so that the materials form high-speed turbulence and are cut into small particles in the area.

(4) Drying by baking

The wet granulator and the dryer are connected by a pipeline and used for conveying particles, the dryer forms negative pressure in a starting state, materials enter the evaporator from an inlet arranged at the lower end of the separation cylinder body in a tangential direction and are continuously and uniformly distributed on the inner wall of the evaporation cylinder body through the distributor arranged in the separation cylinder body, secondary evaporation steam evaporated from the evaporation cylinder body rises to the separation cylinder, liquid drops or foams possibly carried by the secondary steam are separated through the gas-liquid separator arranged in the separation cylinder body, and the secondary evaporation steam is led out of the evaporator from an outlet at the upper end. The scrapers are arranged in the four scraping guide grooves of the rotor, the surface is radially thrown to the inner wall surface of the evaporation cylinder under the action of centrifugal force generated by the rotation of the rotor and simultaneously moves circularly along with the rotor, the scrapers scrape the materials to enable the materials to be in a film turbulent flow state on the evaporation wall surface, so that the aim of quick drying is fulfilled, the particles enter a dryer and are dried for 40 minutes in an environment at 55-65 ℃, and the particles are placed into a material turnover barrel after being dried.

(5) Whole granule

The granular materials are conveyed to a quick granulating machine through a full-automatic feeding machine, are combined and cut by a high-speed rotating blade, and are discharged to a material turnover barrel through a screen plate.

(6) Total mixing

The material turnover barrel enters the main mixing chamber through a turnover vehicle, and is conveyed to a rotary drum of the main mixing machine mixer through a full-automatic feeding machine to simultaneously perform two movements, wherein one movement is the rotation of the rotary drum, and the other movement is the swinging of the rotary drum along with the swinging frame. The materials to be mixed are rotated, turned and mixed in the rotary drum along with the rotary drum, and simultaneously, the materials to be mixed are subjected to mixing movement back and forth left and right along with the swing of the rotary drum, and under the combined action of the two movements, the materials are fully mixed within 5 minutes. After mixing, the particles are discharged to a material turnover barrel through the reverse rotation of the impeller. The material turnover barrel enters the transfer chamber for standby through the turnover vehicle.

2. Post-processing procedure

(1) Tablet production process

(1) Tablet press

First, sampling and measuring the content, and determining the weight of the tablet. After the weight of the tablet is determined, the tablet particles are taken and conveyed to a tabletting chamber by a turnover vehicle for tabletting, the tablet particles are conveyed to the tabletting chamber by a full-automatic feeding machine for tabletting, and the pressed finished tablets are sieved by a powder sieving machine to remove attached medicinal powder, then enter a turnover barrel and are conveyed to a turnover chamber for standby.

(2) Package (I)

And (4) taking the finished product sheets according to the batch packaging instruction, and conveying the finished product sheets to a bottling packaging line through a material transfer vehicle. The medicine packaging process is completed by a bottle arranging machine, a tablet counting machine, a paper plugging machine, a cap screwing machine, an aluminum foil sealing machine, a labeling machine, a film laminating machine and a box sealing machine. And is transported to a finished product warehouse by a transfer vehicle.

(2) Granule production process

(1) Inner bag

Firstly, sampling and measuring the content of the particles, and determining the loading of the particles. After the particle loading amount is determined, the granules are taken and conveyed to a granule inner packaging chamber by a turnover vehicle, the granules are conveyed to a granule inner packaging machine by a full-automatic feeding machine, and finished product particle bags are placed in a turnover box and conveyed to the turnover chamber for later use.

(2) Package (I)

And (4) taking the semi-finished bagged products according to the batch packaging instructions, manually packaging the inner boxes and the packaging boxes according to the process requirements to complete the granule packaging process, and conveying the granules to a finished product warehouse by a transfer car.

(3) Capsule production process

(1) Filling

Sampling and measuring the content to determine the capsule filling amount. After the loading capacity of the capsules is determined, the capsule particles are taken and conveyed to a tabletting chamber by a transfer vehicle for tabletting, the capsules are conveyed to a capsule filling machine by a full-automatic feeding machine (an automatic feeder) for filling, and finished capsules are conveyed to a transfer barrel by a polishing machine and are conveyed to the transfer chamber for later use.

(2) Package (I)

And (4) taking finished capsules according to the batch packaging instruction, conveying the finished capsules to a bottled packaging line through a material transfer vehicle, and conveying the finished capsules to a finished product warehouse through a packaging process by the transfer vehicle.

3. Cleaning yard

The method only produces one medicament each time, changes varieties once every 5 days on average, and needs cleaning the field before changing varieties each time, and when cleaning the field, the equipment is washed by tap water for three times, and the water consumption is about 8m each time ³ Then washing with purified water for one time, wherein the water consumption is 8m ³ Finally, the tablet press or the intragranular or capsule filler is wiped with alcohol in an amount of about 500mL each time.

The present invention is not limited to the above preferred embodiments, and any modifications, equivalents and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (7)

1. A hybrid dissolution device, comprising:

a mixing kettle (10);

the guide flow cover (20) is of a conical structure and is buckled in the mixing kettle (10), an overflow port (21) is formed in the upper part of the guide flow cover (20), an overflowing channel (22) is formed between the lower part of the guide flow cover and the bottom of the mixing kettle (10), and a heater (26) is arranged on the inner side of the guide flow cover and used for heating liquid in the guide flow cover;

the power assembly (30) is arranged on the mixing kettle (10) and is provided with a power shaft (31), and the power shaft (31) extends into the mixing kettle (10) and penetrates through the overflow port (21) to provide rotary power;

the stirring paddle (40) is arranged at the lower part of the mixing kettle (10), is connected with the power shaft (31), and is used for rotating under the driving of the power shaft (31) to stir the liquid in the mixing kettle (10) and push the liquid in the flow guide cover (20) to the outside of the flow guide cover (20) through the overflowing channel (22);

the rolling component (50) is arranged in the overflow port (21), is connected with the power shaft (31) and is used for rolling off starch clusters in the starch liquid;

the rolling component (50) comprises a filter screen (51) and a pressing plate (52), the filter screen (51) is arranged below an overflow port (21) of the air guide sleeve (20), the pressing plate (52) is positioned above the filter screen (51), one end of the pressing plate is connected with the power shaft (31), and particles on the filter screen (51) are rolled under the driving of the power shaft (31);

an overflow adjusting pipe (23) is arranged on the overflow port (21), the overflow adjusting pipe (23) is connected with the overflow port (21) in a sliding and sealing mode along the vertical direction and used for adjusting the height of overflow, the filter screen (51) is arranged in the overflow adjusting pipe (23), and the power shaft (31) penetrates through the overflow adjusting pipe (23) and the filter screen (51); the pressing plate (52) is arranged on the power shaft (31) in a sliding manner along the vertical direction;

the pressure plate (52) is connected with the power shaft (31) in a sliding mode through a sliding sleeve (53), the pressure plate (52) is connected with the sliding sleeve (53) in a rotating mode, and a rotating shaft is perpendicular to the power shaft (31); a first magnet (54) is arranged on the pressing plate (52), a plurality of second magnets (55) are distributed on the filter screen (51), and the first magnet (54) and the second magnets (55) are arranged in a repelling manner; one side of the pressure plate (52) facing the filter screen (51) is provided with a containing groove (56).

2. The mixing and dissolving apparatus according to claim 1, wherein: the filter screen (51) is in overflow regulation pipe (23) leanin sets up, and by the height risees gradually in the direction of overflow regulation pipe (23) inner wall to power shaft (31), the angle of clamp plate (52) with the angle of filter screen (51) cooperatees.

3. The hybrid dissolving apparatus as defined in claim 2, wherein: the overflow adjusting pipe (23) is provided with a traction adjusting assembly for adjusting the height of the overflow adjusting pipe (23); the traction adjusting assembly comprises a traction rod, one end of the traction rod is connected with the overflow adjusting pipe (23), the other end of the traction rod extends to the outside of the mixing kettle (10), or the traction adjusting assembly comprises a floating ball, and the floating ball is arranged on the lower portion of the overflow adjusting pipe (23).

4. The mixing and dissolving apparatus according to claim 1, wherein: the mixing and dissolving device further comprises a feeding assembly (60), a spraying assembly (70) and a discharging assembly (80), wherein the feeding assembly (60) and the spraying assembly (70) are arranged at the upper part of the mixing kettle (10) and are respectively used for feeding powder and liquid materials, the discharging assembly (80) is arranged at the lower part of the mixing kettle (10), and the spraying assembly (70) faces towards the inner wall of the mixing kettle (10) and the outer wall of the flow guide cover (20); the mixing kettle (10) is of a sealing structure, and a negative pressure assembly (90) is arranged on the mixing kettle (10) and used for forming a negative pressure environment in the mixing kettle (10); a vibrator (25) is arranged on the air guide sleeve (20); the air guide sleeve (20) is fixedly connected with the mixing kettle (10) through a plurality of support rods (24), and the support rods (24) are elastic rods.

5. The hybrid dissolving apparatus as defined in claim 1, wherein: the stirring paddle (40) comprises an inner stirring portion (41), a pushing portion (42) and an outer stirring portion (43), the inner stirring portion (41) is located in the flow guide cover (20) and connected with the power shaft (31) and used for stirring materials in the flow guide cover (20), the pushing portion (42) is connected with the outer end of the inner stirring portion (41) and located below the lower edge of the flow guide cover (20) and used for pushing liquid in the flow guide cover (20) to the outside of the flow guide cover (20) from the overflowing channel (22), and the outer stirring portion (43) is connected with the outer end of the pushing portion (42) and used for driving the liquid outside the flow guide cover (20) to rotate.

6. A wet granulation process comprising the steps of:

mixing and dissolving the raw materials by using the mixing and dissolving device as defined in any one of claims 1 to 5.

7. The wet granulation process of claim 6, further comprising the steps of:

A. crushing, namely crushing the medicine raw materials into powder;

B. pulping, namely mixing and dissolving starch and water in the mixing and dissolving device to form starch slurry;

C. granulating, namely mixing the medicine raw materials crushed into powder in the step A and the starch slurry formed in the step B by adopting a wet granulator to prepare granules;

D. drying, drying the granules prepared in the step C;

E. and D, preparing the dried granules in the step D into granules and tablets according to required dosage forms, and packaging.

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