CN115575650A - Sample analyzer and maintenance method of sample analyzer - Google Patents
Sample analyzer and maintenance method of sample analyzer Download PDFInfo
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- CN115575650A CN115575650A CN202110758382.4A CN202110758382A CN115575650A CN 115575650 A CN115575650 A CN 115575650A CN 202110758382 A CN202110758382 A CN 202110758382A CN 115575650 A CN115575650 A CN 115575650A
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- 238000000034 method Methods 0.000 title claims abstract description 200
- 238000012360 testing method Methods 0.000 claims abstract description 184
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- 230000007246 mechanism Effects 0.000 claims description 169
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- 238000007885 magnetic separation Methods 0.000 claims description 115
- 239000007788 liquid Substances 0.000 claims description 104
- 238000004140 cleaning Methods 0.000 claims description 75
- 239000002699 waste material Substances 0.000 claims description 52
- 238000002156 mixing Methods 0.000 claims description 38
- 239000012295 chemical reaction liquid Substances 0.000 claims description 34
- 238000011068 loading method Methods 0.000 claims description 31
- 239000000243 solution Substances 0.000 claims description 29
- 238000002347 injection Methods 0.000 claims description 22
- 239000007924 injection Substances 0.000 claims description 22
- 238000007599 discharging Methods 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 10
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- 238000011534 incubation Methods 0.000 claims description 9
- 238000010521 absorption reaction Methods 0.000 claims description 8
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- 239000011324 bead Substances 0.000 claims description 4
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The embodiment of the application provides a sample analyzer and a maintenance method of the sample analyzer, which are used for meeting the demand of the sample analyzer for testing samples at any time when the sample analyzer executes a maintenance process. The maintenance method of the sample analyzer in the embodiment of the application comprises the following steps: controlling the sample analyzer to execute a first maintenance process to maintain the component to be maintained; obtaining a sample test instruction; controlling the sample analyzer to stop executing the first maintenance process and perform mechanical reset; and controlling the sample analyzer to simultaneously execute a second maintenance process and a sample testing process, so that the sample analyzer performs sample testing on the sample while maintaining the component to be maintained.
Description
Technical Field
The invention relates to the technical field of biochemical analysis and detection, in particular to a sample analyzer and a maintenance method of the sample analyzer.
Background
Sample analysis devices are a class of analytical instruments with high sensitivity and specificity, such as fully automatic immunoassays, which are simple to operate and are often used in clinical laboratories to detect various analytical indicators of blood, urine, or other bodily fluids.
In clinical practice, emergency treatment often occurs, which requires that various analysis indexes of a patient sample be known in a short time, and therefore, the detection time of emergency treatment items is of great concern.
When a user performs an emergency test, the instrument is typically idle, stopped for a fault, under test, or under automatic maintenance. If the instrument just starts the routine maintenance automatic program, the user needs to perform an emergency sample test, and the time of the routine maintenance process can directly influence the time of the emergency sample test. The user now has 2 choices:
1. stopping the maintenance flow to enable the instrument to be in a stop state, executing an instrument resetting action to enable the instrument to enter an idle state, adding a test at the moment, sacrificing the maintenance flow at the moment, and enabling a user to apply for the test only after waiting for at least 6 min;
2. and after the current maintenance flow is finished, the user adds the test, and the user can only apply for the test after waiting about 50 min.
However, the above two selection methods cannot satisfy the demand of the user for the sample to be measured at any time.
Disclosure of Invention
The embodiment of the invention provides a sample analyzer and a maintenance method of the sample analyzer, which are used for meeting the demand of the sample analyzer for testing samples at any time when the sample analyzer executes a maintenance process.
A first aspect of embodiments of the present application provides a sample analyzer, including:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation and cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the blending mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
the controller is used for controlling the sample analyzer to be switched from a first maintenance mode to a second maintenance mode if a sample testing instruction is detected when the sample analyzer executes a first maintenance process;
wherein if the sample analyzer is in the first maintenance mode, the controller controls the sample analyzer to execute the first maintenance procedure;
and if the sample analyzer is in the second maintenance mode, the controller controls the sample analyzer to execute a second maintenance process and simultaneously execute a sample testing process.
Preferably, the second maintenance flow includes at least more control commands to the waste liquid suction unit and the reagent unit than the first maintenance flow.
Preferably, the waste liquid sucking unit at least comprises a waste liquid sucking needle and a waste liquid pump, and the reagent unit comprises a reagent disk;
the control instruction of the water absorption and waste liquid unit specifically comprises the following steps: controlling the waste liquid suction needle and the waste liquid pump to suck the reaction liquid in the reaction cup after the test is finished;
the control instruction for the reagent unit specifically includes: and controlling the reagent disk to uniformly mix the magnetic bead reagent.
Preferably, the second maintenance process comprises a plurality of maintenance cycles, and the sample test process comprises a test cycle;
the controller controls the test cycle and at least one of the maintenance cycles to be performed simultaneously while the sample analyzer is in the second maintenance mode.
Preferably, the maintenance cycle is divided into a plurality of target time periods, one or more maintenance sub-actions are executed in each target time period, the test cycle is divided into a plurality of target time periods, and one or more test sub-actions are executed in each target time period;
the controller controls the test period and at least one maintenance period to be performed simultaneously, and the method comprises the following steps:
the controller controls the sample analyzer to simultaneously perform a test sub-action and a maintenance sub-action of at least one maintenance cycle for at least one target time period.
Preferably, the maintenance sub-action within the maintenance period is the same as the test sub-action within the test period.
Preferably, in the second maintenance mode, one or more blank periods are provided between the plurality of maintenance periods to insert the sample test flow.
Preferably, one or more blank periods are arranged between every two maintenance periods so as to insert the sample testing process.
Preferably, the second maintenance flow comprises a plurality of maintenance sub-actions executed in sequence, and the sample test flow comprises a plurality of test sub-actions executed in sequence;
the controller controls the sample analyzer to perform at least one maintenance sub-action and at least one test sub-action simultaneously while the sample analyzer is in the second maintenance mode.
Preferably, before the second maintenance mode is executed, the controller is further configured to:
sending out information for prompting a user to execute pre-test preparation on the test reagent;
and/or the presence of a gas in the atmosphere,
and sending out information for prompting the user to prepare the maintenance equipment before maintenance.
Preferably, before the second maintenance mode is executed, the controller is further configured to:
and sending information for prompting a user to put a device for bearing the intensified cleaning solution into the reagent unit.
Preferably, before executing the second maintenance mode, the controller is further configured to:
and controlling an execution part in the maintenance process and an execution part in the sample testing process to execute mechanical reset.
A second aspect of the embodiments of the present application provides a method for maintaining a sample analyzer, including:
controlling the sample analyzer to execute a first maintenance process to maintain the component to be maintained;
obtaining a sample test instruction;
controlling the sample analyzer to stop executing the first maintenance process and perform mechanical reset;
and controlling the sample analyzer to simultaneously execute a second maintenance process and a sample testing process, so that the sample analyzer performs sample testing on the sample while maintaining the component to be maintained.
Preferably, the second maintenance flow includes at least more control commands to the waste liquid suction unit and the reagent unit than the first maintenance flow.
Preferably, the waste liquid sucking unit at least comprises a waste liquid sucking needle and a waste liquid pump, and the reagent unit comprises a reagent disk;
the control instruction of the water absorption and waste liquid unit specifically comprises the following steps: controlling the waste liquid sucking needle and the waste liquid pump to suck the reaction liquid in the reaction cup after the test is finished;
the control instruction for the reagent unit specifically includes: and controlling the reagent disk to uniformly mix the magnetic bead reagent.
Preferably, the second maintenance process comprises a plurality of maintenance cycles, and the sample test process comprises a test cycle;
controlling the sample analyzer to simultaneously execute a second maintenance procedure and a sample testing procedure, including:
controlling the sample analyzer to perform the test cycle and at least one of the maintenance cycles simultaneously.
Preferably, the maintenance cycle is divided into a plurality of target time periods, one or more maintenance sub-actions are executed in each target time period, the test cycle is divided into a plurality of target time periods, and one or more test sub-actions are executed in each target time period;
controlling the sample analyzer to simultaneously execute a second maintenance procedure and a sample testing procedure, including:
controlling the sample analyzer to simultaneously perform a test sub-action and a maintenance sub-action of at least one maintenance cycle for at least one target time period.
Preferably, the maintenance sub-action within the maintenance period is the same as the test sub-action within the test period.
Preferably, one or more blank periods are provided between the plurality of maintenance periods to insert the sample testing procedure.
Preferably, one or more blank periods are provided between every two maintenance periods to insert the sample testing process.
Preferably, the second maintenance flow comprises a plurality of maintenance sub-actions executed in sequence, and the sample test flow comprises a plurality of test sub-actions executed in sequence;
controlling the sample analyzer to simultaneously execute a second maintenance procedure and a sample testing procedure, including:
controlling the sample analyzer to perform at least one maintenance sub-action and at least one test sub-action simultaneously.
Preferably, before executing the second maintenance flow, the method further includes:
sending out information for prompting a user to execute pre-test preparation on the test reagent;
and/or the presence of a gas in the gas,
and sending out information for prompting the user to prepare the maintenance equipment before maintenance.
Preferably, before executing the second maintenance flow, the method further includes:
and sending information for prompting a user to put a device for bearing the intensified cleaning solution into the reagent unit.
Preferably, before executing the second maintenance flow, the method further includes:
and controlling an execution part in the maintenance process and an execution part in the sample testing process to execute mechanical reset.
A third aspect of the embodiments of the present application provides a method for maintaining a sample analyzer, including:
controlling a sample analyzer to perform a first maintenance procedure to maintain a part to be maintained, the first maintenance procedure comprising:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a magnetic separation unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup and place the reaction cup on a preset hole position of the reaction disc;
and step 3: the reaction disc is controlled to position the preset hole position to a rear operation position, so that the grabbing and transferring mechanism can place the reaction cup into the magnetic separation disc of the magnetic separation unit;
and 4, step 4: controlling the magnetic separation disc to move so as to convey the reaction cup to a position below a first liquid injection needle of the magnetic separation disc, and controlling the first liquid injection needle to inject a preset amount of cleaning liquid into the reaction cup;
and 5: controlling the magnetic separation disc to move so as to convey the reaction cup after liquid injection to the lower part of the first liquid suction needle, and starting magnetic separation liquid suction to complete cleaning of the first liquid suction needle;
step 6: sequentially conveying the reaction cups to the positions below the residual liquid injection needles and the residual liquid suction needles in the magnetic separation disc to complete cleaning of the residual liquid suction needles;
and 7: controlling the magnetic separation disc to move so as to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup;
if the sample analyzer detects a sample test instruction when the sample analyzer executes the action instruction in the step 5 in the first maintenance process, controlling the reaction cup loading mechanism, the sample unit, the sample dispensing mechanism, the reagent unit, the reagent dispensing mechanism, the reaction disk, the blending mechanism, the measuring unit, the magnetic separation unit, the waste liquid suction unit and the grabbing and transferring mechanism in the sample analyzer to execute mechanical reset, and after the mechanical reset is completed, controlling the sample analyzer to execute a second maintenance process, and controlling the magnetic separation disk to move in the process of executing the mechanical reset on the magnetic separation unit so as to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup;
wherein the second maintenance procedure comprises:
step 1: controlling the grabbing and transferring mechanism to grab a reaction cup from the reaction cup loading mechanism to the sample loading position of the reaction tray;
step 2: controlling the sample dispensing mechanism to suck a sample from the sample unit, and then discharging the sucked sample to a reaction cup at the sample adding position;
and step 3: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to sample adding to a reagent adding position of the reaction tray;
and 4, step 4: uniformly mixing the reagents in the reagent units, controlling a reagent dispensing mechanism to suck the reagents from the reagent units and then discharging the reagents into reaction cups in the reagent adding positions;
and 5: controlling the grabbing and transferring mechanism to convey the reaction cups added with the reagents to the blending mechanism for blending;
and 6: controlling the grabbing and transferring mechanism to convey the reaction cups in the blending mechanism to a post-operation position of the reaction tray for incubation;
and 7: after the incubation is finished, controlling the grabbing and transferring mechanism to convey the reaction cups at the post-operation position to the magnetic separation unit for magnetic separation and cleaning;
and step 8: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to the magnetic separation cleaning to the measuring unit for measurement;
and step 9: controlling the grabbing and transferring mechanism to convey the measured reaction cup to a waste liquid absorption level in the reaction disc, so that the waste liquid absorption unit absorbs the reaction liquid in the reaction cup after the test is finished;
step 10: and controlling the grabbing and transferring mechanism to convey the reaction cups with the waste liquid suction levels to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cups from the rear operation position.
A fourth aspect of the embodiments of the present application provides a sample analyzer, including:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the uniformly mixing mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
and the controller is used for controlling the sample analyzer to execute a sample test process on the sample to be tested while executing a maintenance process on the part to be maintained.
According to the technical scheme, the embodiment of the invention has the following advantages:
in the embodiment of the application, if the sample analyzer detects a sample test instruction during execution of a maintenance process, the controller controls the sample analyzer to be switched from a first maintenance mode to a second maintenance mode; wherein if the sample analyzer is in the first maintenance mode, the controller controls the sample analyzer to execute a maintenance procedure; and if the sample analyzer is in the second maintenance mode, the controller controls the sample analyzer to execute a sample testing process while executing the maintenance process. The second maintenance mode in the embodiment of the application can enable the maintenance process and the sample testing process to be executed synchronously, so that the requirement of the sample analyzer on the sample testing when the sample analyzer executes the maintenance process is met.
Drawings
FIG. 1 is a schematic diagram of the structure of a sample analyzer in an embodiment of the present application;
FIG. 2 is a schematic control flow chart of the controller of the sample analyzer before the second maintenance mode is executed in the embodiment of the present application;
FIG. 3 is a schematic diagram of one embodiment of a method for maintaining a sample analyzer in an embodiment of the present application;
fig. 4 is a schematic diagram of another embodiment of a method for maintaining a sample analyzer in an embodiment of the present application.
Detailed Description
The embodiment of the invention provides a sample analyzer and a maintenance method of the sample analyzer, which are used for meeting the demand of the sample analyzer for testing samples at any time when the sample analyzer executes a maintenance process.
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terms "first," "second," "third," "fourth," and the like in the description and in the claims, as well as in the drawings, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It will be appreciated that the data so used may be interchanged under appropriate circumstances such that the embodiments described herein may be implemented in other sequences than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Before describing the present application in detail, a structure of a sample analyzer will be described, and referring to fig. 1, the sample analyzer in one embodiment includes a cuvette loading mechanism 1, a sample unit 2, a sample dispensing mechanism 3, a reagent unit 4, a reagent dispensing mechanism 5, a reaction disk 6, a kneading mechanism 7, a measurement unit 8, a magnetic separation unit 9, a grasping and transferring mechanism 10, a waste liquid suction unit 11, and a controller 12.
The following is a detailed description:
the cuvette loading mechanism 1 is for supplying and carrying cuvettes to the cup dispensing position. In one embodiment, the cup separating position is used for the grabbing and transferring mechanism to dispatch the reaction cup to the sample adding position.
The sample unit 2 is used for carrying a sample, and in some embodiments, the sample unit 2 may include a sample distribution Module (second DM) and a front end track; the sample cell 2 may also be a sample disk comprising a plurality of sample sites on which samples such as sample tubes can be placed, and the sample disk may dispatch the samples to corresponding positions, for example, positions for the sample dispensing mechanism 3 to suck the samples, by rotating its disk structure. The sample dispensing mechanism 3 is used for sucking a sample and discharging the sample into a reaction cup to be loaded. For example, the sample dispensing mechanism 3 may include a sample needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the sample needle can be moved to aspirate a sample carried by the sample unit 2 and to a cuvette to be loaded and discharge the sample to the cuvette.
The reagent unit 4 is for carrying a reagent. In one embodiment, the reagent unit 4 may be a reagent disk, which is configured in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent unit 4 can rotate and drive the reagent containers carried by the reagent unit to rotate to a specific position, for example, a position for sucking reagent by the reagent dispensing mechanism 5. The number of the reagent unit 4 may be one or more. The reagent dispensing mechanism 5 is used to suck a reagent and discharge it into a reaction cup to which the reagent is to be added. In one embodiment, the reagent dispensing mechanism 5 may include a reagent needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the reagent needle can move to aspirate a reagent carried by the reagent unit 4 and to a cuvette to which the reagent is to be added and discharge the reagent to the cuvette.
The blending mechanism 7 is used for blending the reaction liquid to be blended in the reaction cup. The number of the kneading mechanisms 7 may be one or more.
The reaction tray 6 has at least one placing position for placing a reaction cup and incubating a reaction solution in the reaction cup. For example, the reaction tray 6 may be configured in a disc-shaped structure, and has one or more placing positions for placing reaction cups, and the reaction tray can rotate and drive the reaction cups in the placing positions to rotate, so as to schedule the reaction cups in the reaction tray and incubate the reaction solution in the reaction cups.
The measuring unit 8 is used for detecting and analyzing the reaction cup loaded with the mixed solution of the sample and the reagent to obtain test data. The assay unit 8 may in some embodiments comprise an incubation device and a photometric component. The incubation device has at least one placing position for placing the reaction cup and incubating the reaction solution in the reaction cup. For example, the incubation device may be a reaction tray, which is arranged in a disc-shaped structure and has one or more placing positions for placing reaction cups, and the reaction tray can rotate and drive the reaction cups in the placing positions to rotate, so as to schedule the reaction cups in the reaction tray and incubate reaction solutions in the reaction cups. And the light measurement component is used for performing light measurement on the incubated reaction solution to obtain the reaction data of the sample. For example, the photometric device detects the light emission intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample from the calibration curve.
And the grabbing and transferring mechanism 10 is used for completing the dispatching of the reaction cups by matching with each unit.
The waste liquid sucking unit 11 is used for sucking the reaction liquid in the reaction cup after the test is finished.
The controller 12 includes at least: the device comprises a processing component, a communication interface, a memory and an I/O interface, wherein the processing component, the communication interface, the memory and the I/O interface are communicated through a bus, and the processing component can be a CPU, a GPU or other chips with operation capability. The communication interface may be an interface of any communication protocol known at present. The communication interface communicates with the outside through a network. The controller 12 may communicate data with any device connected through the network via a communication interface in a communication protocol.
Based on the sample analyzer described in fig. 1, the following describes in detail a sample analyzer in an embodiment of the present application, and an embodiment of the sample analyzer in the embodiment of the present application includes:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation and cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the blending mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
the controller is used for controlling the sample analyzer to be switched from a first maintenance mode to a second maintenance mode if a sample testing instruction is detected when the sample analyzer executes a first maintenance process;
wherein if the sample analyzer is in the first maintenance mode, the controller controls the sample analyzer to execute the first maintenance procedure;
and if the sample analyzer is in the second maintenance mode, the controller controls the sample analyzer to execute a second maintenance process and simultaneously execute a sample testing process.
The control flow in the controller is described in detail below:
the first maintenance process in the first maintenance mode in the embodiment of the present application refers to a routine maintenance process, and the routine maintenance process in the embodiment of the present application includes a cleaning process of the magnetic separation disk, or a routine soaking and cleaning process of the sample needle, the reagent needle, or the magnetic separation pipette needle.
Specifically, for convenience of understanding, the following detailed description is made of the cleaning process of the magnetic separation disk, and the daily soaking and cleaning process of the sample needle, the reagent needle, and the magnetic separation pipette needle:
wherein, the cleaning process of the magnetic separation disc comprises the following steps:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a magnetic separation unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup to be placed in a preset hole position of the reaction disc;
and step 3: the reaction disc is controlled to position a preset hole position to a rear operation position so that the grabbing and transferring mechanism can place the reaction cup into the magnetic separation disc of the magnetic separation unit;
and 4, step 4: controlling the magnetic separation disc to move so as to convey the reaction cup to the position below a first liquid injection needle of the magnetic separation disc, and controlling the first liquid injection needle to inject a preset amount of cleaning liquid into the reaction cup;
and 5: controlling the magnetic separation disc to move so as to convey the reaction cup after liquid injection to the lower part of the first liquid suction needle, and starting magnetic separation liquid suction to complete cleaning of the first liquid suction needle;
step 6: sequentially conveying the reaction cups to the positions below the residual liquid injection needles and the residual liquid suction needles in the magnetic separation disc to complete cleaning of the residual liquid suction needles;
and 7: the magnetic separation disc is controlled to move to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup.
Further, the daily soaking and cleaning process of the sample needle or the reagent needle comprises the following steps:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a sample dispensing mechanism (sample needle), a reagent dispensing mechanism (reagent needle) and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup and place the reaction cup on the sample adding position of the reaction tray;
and 3, step 3: controlling a sample dispensing mechanism to suck 20ul of reinforced cleaning solution from a reinforced cleaning position and add the reinforced cleaning solution into a reaction cup at a sample adding position, and then controlling the sample dispensing mechanism to suck (sample needle) to move to a cleaning pool for cleaning;
and 4, step 4: controlling a grabbing and transferring mechanism to grab the reaction cup at the sample adding position to the outer ring of the reaction disc;
and 5: controlling a reagent dispensing mechanism (reagent needle) to suck 15ul of cleaning solution from a reaction cup on the outer ring of the reaction disk, controlling the reagent dispensing mechanism (reagent needle) to return to a cleaning pool, stopping movement (not cleaning), and waiting for 3 minutes;
step 6: controlling a sample dispensing mechanism to suck 20ul of the intensified cleaning liquid from the intensified cleaning position (sample needle), returning to the cleaning pool, stopping movement (not cleaning) and waiting for 3 minutes.
Further, the daily soaking and cleaning process of the magnetic separation liquid suction needle comprises the following steps:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a magnetic separation unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup to be placed in a preset hole position of the reaction disc;
and step 3: the reaction disc is controlled to position a preset hole position to a rear operation position so that the grabbing and transferring mechanism can place the reaction cup into the magnetic separation disc of the magnetic separation unit;
and 4, step 4: controlling the magnetic separation motion to convey the reaction cup to the position below a first liquid injection needle of the magnetic separation disc, and controlling the first liquid injection needle to inject a preset amount of cleaning liquid into the reaction cup;
and 5: controlling the magnetic separation disc to move so as to convey the reaction cup after liquid injection to the lower part of the first liquid suction needle, controlling the liquid suction needle to move to the bottom of the reaction cup after liquid injection, starting a waste liquid pump connected with the first liquid suction needle, and sucking liquid for N seconds;
step 6: waiting for 3 minutes, controlling the magnetic separation disc to move so as to position the reaction cup subjected to liquid suction to the magnetic separation disc operation position, so that the grabbing and transferring mechanism can transfer the reaction cup subjected to liquid suction to the reaction disc;
and 7: and controlling the grabbing and transferring mechanism to discard the reaction cups after imbibing.
Different from the first maintenance mode, the second maintenance mode in the embodiment of the present application includes both the second maintenance flow and the sample test flow, that is, in the second maintenance mode, the second maintenance flow and the sample test flow are executed simultaneously.
It should be noted that the second maintenance flow in the second maintenance mode is also used for performing daily maintenance, such as cleaning of the magnetic separation disk, or daily immersion cleaning of the sample needle, the reagent needle, or the magnetic separation pipette needle, but the timing operation command in the second maintenance flow is different from the timing operation command in the first maintenance flow, and the timing operation command here refers to an operation command executed at different time.
The first maintenance mode only executes the first maintenance flow, and the second maintenance mode not only executes the second maintenance flow, but also executes the sample test flow, namely in the second maintenance mode, the maintenance flow and the sample test flow of the sample analyzer can be simultaneously executed, so that when the controller detects a sample test instruction, if the sample analyzer is in the first maintenance mode, the first maintenance mode is switched to the second maintenance mode, and the requirement of the sample to follow-up test is met.
Further, in the second maintenance mode, the second maintenance procedure and the sample test procedure can be performed simultaneously, because in the second maintenance mode, the executive component of the second maintenance procedure and the executive component of the sample test procedure use the same component of the sample analyzer in a time-sharing manner (i.e. do not use the same component of the sample analyzer at the same time), and when the executive component of the second maintenance procedure uses a sample needle, the executive component of the sample test procedure cannot use the sample needle, or use a sample needle different from the second maintenance procedure, thereby ensuring that the second maintenance procedure and the sample test procedure do not have a conflicting phenomenon.
Based on the control flow in the above embodiment, the second maintenance flow and the sample test flow in the second maintenance mode are described in detail below:
in an embodiment, the application scenarios for the simultaneous execution of the second maintenance process and the sample testing process are as follows:
the second maintenance procedure includes a plurality of maintenance cycles, the sample test procedure includes one test cycle, and in the second maintenance mode, the simultaneous execution of the second maintenance procedure and the sample test procedure may be: one test cycle is performed simultaneously with at least one maintenance cycle.
Specifically, the maintenance cycle is divided into a plurality of target time periods according to the cycle duration, each target time period executes one or more maintenance sub-actions, the test cycle is divided into a plurality of target time periods according to the cycle duration, and each target time period executes one or more test sub-actions.
In the second maintenance mode, the simultaneous execution of the second maintenance process and the sample test process may further be: the sample analyzer simultaneously performs the test sub-action and the maintenance sub-action of the at least one maintenance cycle for at least one target time period.
Further, in order to facilitate the control of the second maintenance process and the sample test process, the maintenance sub-action of the maintenance period may be set to be the same as the test sub-action in the test period.
Because the maintenance sub-actions in the second maintenance flow are the same as the test sub-actions in the sample test flow, and the maintenance sub-actions in the first maintenance flow are different from the maintenance sub-actions in the second maintenance flow, the second maintenance flow has at least more control commands for the waste liquid unit and the reagent unit than the first maintenance flow.
Specifically, inhale waste liquid unit and include inhaling waste liquid needle and waste liquid pump, reagent unit includes the reagent dish, specifically includes to the control command of reagent unit: control reagent dish carries out the mixing to the magnetic bead reagent, and specifically includes to inhaling the control command of waste liquid unit: and controlling a waste liquid sucking needle and a waste liquid pump to suck the reaction liquid in the reaction cup after the test is finished.
It should be noted that the above control commands for the pipette waste unit and the reagent unit are only illustrative and not limiting of the difference between the first maintenance procedure and the second maintenance procedure, and the difference between the first maintenance procedure and the second maintenance procedure is essentially the difference between the first maintenance procedure and the sample testing procedure.
When the first maintenance flow is the cleaning flow of the magnetic separation disc, the difference between the first maintenance flow and the sample testing flow is the difference between the cleaning flow and the sample testing flow of the magnetic separation;
when the first maintenance process is a daily soaking and cleaning process of the sample needle, the reagent needle or the magnetic separation pipette needle, the difference between the first maintenance process and the sample testing process is the difference between the daily soaking and cleaning process of the sample needle, the reagent needle or the magnetic separation pipette needle and the sample testing process.
For ease of understanding, table 1 presents an exploded schematic view of the sub-actions in the second maintenance flow and the sub-actions in the sample testing flow.
TABLE 1
As can be seen from table 1: the sample testing process is divided into 11 target time periods in the testing cycle, wherein each target time period executes one or more testing sub-actions, the second maintenance process is also divided into 11 target time periods in the maintenance cycle, wherein each target time period executes one or more maintenance sub-actions, and in order to realize synchronous control of the sample testing process and the second maintenance process and improve the convenience of control, the testing sub-actions and the maintenance sub-actions are set to be the same actions in the embodiment of the application.
It should be noted that, the test sub-action and the maintenance sub-action are customized by the user, for example, in the sample test period, the test sub-action executed in the T1 time period may be referred to as one test sub-action, and the test sub-action executed in the T1 time period may also be referred to as a plurality of test sub-actions. That is, sub-actions may be defined from multiple dimensions, and if it is defined that an action executed in one time period is one sub-action, all test sub-actions in the T1 time period are referred to as one test sub-action, and if an execution subject is used as a standard for dividing sub-actions, a plurality of sub-actions in the T1 time period are executed by different execution subjects, and all test sub-actions in the T1 time period are referred to as a plurality of test sub-actions.
In addition, it should be noted that in the second maintenance mode, the nature of the simultaneous execution of the sample test flow and the second maintenance flow is that the execution component of the second maintenance flow and the execution component of the sample test flow use the same component in the sample analyzer in a time-sharing manner, but in order to facilitate the control of the simultaneous execution of the sample test flow and the second maintenance flow, the sub-actions in the second maintenance flow are set to be the same as the sub-actions in the sample test flow, and in practical applications, the sub-actions in the second maintenance flow may also be different from the sub-actions in the sample test flow, as long as the time-sharing use of the same component in the sample analyzer can be implemented, which is not limited herein.
Therefore, when the second maintenance flow includes a plurality of cycles, the maintenance sub-actions in each cycle may be completely the same, may also be completely different, or may be partially the same, as long as the execution component of the second maintenance flow and the execution component of the sample testing flow can be realized to share the same component in the sample analyzer.
Further, the first maintenance process in the first maintenance mode further includes a daily soaking and cleaning process of the sample needle, the reagent needle, or the magnetic separation pipette needle, and since the soaking is generally required for 3 minutes in the daily soaking and cleaning process, while in the sample test process, the pipetting time of the sample needle is generally 1.0 second, and according to the principle of equivalence, the sample needle can be considered to be soaked for 1.0 second, and at the same time, according to the experimental verification, the sample needle aspirates and discharges the intensified cleaning liquid 100 times, which corresponds to the effect of internal cleaning for 3 minutes, so in order to achieve the effect of daily soaking and cleaning, the sample needle only needs to perform aspiration and discharge operations for 100 cycles, and in each sample test process, the sample needle needs to aspirate and discharge the sample once, so the present embodiment can set the sub-operations in the second maintenance mode to be the same as the sub-operations in the sample test process, and set the sample needle and the reagent needle in the second maintenance process to aspirate and discharge the intensified cleaning liquid, and the sample needle and the reagent in the sample test process to aspirate and discharge the sample and discharge the intensified cleaning liquid, respectively.
For ease of understanding, table 2 presents a sub-action decomposition diagram of the second maintenance procedure and the sample testing procedure for performing daily soak cleaning:
TABLE 2
It should be noted that, in order to achieve the same cleaning effect as the daily soaking cleaning, the second maintenance flow of 100 cycles needs to be executed in table 2, and for convenience of understanding, only the second maintenance flow of 2 cycles is given in table 2 for illustration.
In addition, in order to execute the sample testing process at any time in the process of executing daily soaking and cleaning by the reagent needle, the sample needle and the magnetic separation pipette needle, one or more blank periods can be set between a plurality of maintenance periods to insert the sample testing process, and further, in order to increase the convenience of inserting the sample testing process, one or more blank periods can be set between every two maintenance periods, so that the sample testing process can be inserted into the blank periods at any time when the sample analyzer detects a sample testing instruction, and the convenience of executing the sample testing process is realized.
The second maintenance procedure and the sample test procedure in the second maintenance mode are described in detail above from the viewpoint that the second maintenance procedure includes a plurality of cycles, and the second maintenance procedure and the sample test procedure in the second maintenance mode are described next:
in one embodiment, the application scenario of the second maintenance mode is as follows:
when the sample analyzer is in the second maintenance mode, in order to enable the sample testing process and the second maintenance process to be executed simultaneously, the controller only needs to control the sample analyzer to execute at least one testing sub-action and at least one maintenance sub-action simultaneously, and therefore the sample testing process and the second maintenance process can be executed simultaneously.
Further, before the sample analyzer executes the second maintenance mode, the controller further needs to execute the following process, specifically referring to fig. 2:
201. controlling an execution component in the second maintenance flow and an execution component in the sample testing flow to execute mechanical reset;
in order to ensure the normal execution of the second maintenance process and the sample testing process, it is easy to understand that the execution part in the second maintenance process and the execution part in the sample testing process need to be controlled to execute mechanical reset before the second maintenance mode is executed.
Specifically, the mechanical reset is executed by controlling a reaction cup loading mechanism, a sample unit, a sample dispensing mechanism, a reagent unit, a reagent dispensing mechanism, the reaction disk, a mixing mechanism, a measuring unit, the magnetic separation unit, a waste liquid suction unit and a grabbing and transferring mechanism in the sample analyzer.
202. Sending out information for prompting a user to perform preparation before test on the test reagent, and/or sending out information for prompting the user to perform preparation before maintenance on the maintenance equipment;
if the second maintenance flow is a cleaning flow of the magnetic separation disc, or a daily soaking and cleaning flow of the sample needle, the reagent needle or the magnetic separation needle, in order to enable the second maintenance flow and the sample testing flow to be normally executed simultaneously, information prompting a user to perform preparation before testing on the test reagent needs to be sent, and/or information prompting the user to perform preparation before maintenance on the maintenance equipment needs to be sent.
Specifically, the pre-test preparation information includes, but is not limited to, performing a mixing operation on the test reagent, and the pre-maintenance preparation information includes, but is not limited to, establishing a vacuum environment for the magnetic separation needle to be cleaned, and the like.
203. And sending information for prompting a user to put a device for bearing the reinforced cleaning solution in the reagent unit.
Specifically, since the sample needle, the reagent needle, or the magnetic separation needle needs to be cleaned with the intensified cleaning solution when the daily soaking and cleaning procedure is performed, the user needs to be prompted to enter information of a device carrying the intensified cleaning solution into the reagent unit so as to facilitate the sample needle, the reagent needle, or the magnetic separation needle to suck the intensified cleaning solution.
In the embodiment of the application, the action to be executed before the second maintenance mode is executed is described in detail, so that the second maintenance flow and the sample test flow in the second maintenance mode can be executed simultaneously.
Based on the sample analyzer described in fig. 1, another embodiment of a sample analyzer is described next, the sample analyzer comprising:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation and cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the uniformly mixing mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
and the controller is used for controlling the sample analyzer to execute a sample test process on the sample to be tested while executing a maintenance process on the part to be maintained.
Unlike the sample analyzer in the above embodiment, the sample analyzer in the embodiment of the present application does not distinguish between the first maintenance mode and the second maintenance mode, and the controller in the embodiment of the present application is configured to execute the following control flow:
and controlling the sample analyzer to execute a sample test process on the sample to be tested while executing a maintenance process on the component to be maintained.
Specifically, the description of the control flow in the embodiment of the present application is similar to the description of the second maintenance mode control flow in the embodiment described above, and is not repeated here.
In the above description of the sample analyzer in the embodiment of the present application, the following description is made of a maintenance method of the sample analyzer in the embodiment of the present application, please refer to fig. 3: an embodiment of a method for maintaining a sample analyzer in an embodiment of the present application includes:
301. controlling the sample analyzer to execute a first maintenance process to maintain the component to be maintained;
specifically, the first maintenance process in the first maintenance mode in the embodiment of the present application refers to a routine maintenance process, and the routine maintenance process in the embodiment of the present application includes a cleaning process of the magnetic separation disk, or a routine soaking and cleaning process of the sample needle, the reagent needle, or the magnetic separation pipette needle.
The cleaning process of the magnetic separation disk, or the routine soaking and cleaning process of the sample needle, the reagent needle and the magnetic separation pipette needle, is similar to that described in the above sample analyzer, and will not be described again here.
302. Obtaining a sample test instruction;
when the sample analyzer executes the first maintenance process and obtains the sample test instruction, step 303 is executed.
303. Controlling the sample analyzer to stop executing the first maintenance process and perform mechanical reset;
when the sample analyzer executes the first maintenance flow and detects a sample testing instruction, the sample analyzer is controlled to stop executing the first maintenance flow and perform mechanical reset, so that the sample analyzer executes the second maintenance flow and the sample testing flow.
Specifically, when the sample analyzer performs mechanical reset, all execution components related to the second maintenance process and the sample testing process may be controlled to perform mechanical reset, so as to ensure normal operation of the second maintenance process and the sample testing process.
The mechanical reset executing component at least comprises a reaction cup loading mechanism, a sample unit, a sample separate injection mechanism, a reagent unit, a reagent separate injection mechanism, the reaction disc, a uniform mixing mechanism, a measuring unit, the magnetic separation unit, a waste liquid sucking unit and a grabbing and transferring mechanism.
304. And controlling the sample analyzer to simultaneously execute the second maintenance flow and the sample testing flow, so that the sample analyzer performs sample testing on the sample while maintaining the part to be maintained.
And controlling the sample analyzer of the sample analyzer to simultaneously execute a second maintenance flow and a sample test flow, so that the sample analyzer performs sample test on the sample while maintaining the component to be maintained.
Specifically, the description of the second maintenance procedure and the sample testing procedure performed simultaneously on the sample analyzer is similar to the description of the second maintenance mode in the sample analyzer, and is not repeated here.
In the embodiment of the application, a sample analyzer is controlled to execute a first maintenance process so as to maintain a component to be maintained; obtaining a sample test instruction; controlling the sample analyzer to stop executing the first maintenance process and perform mechanical reset; and controlling the sample analyzer to simultaneously execute a second maintenance process and a sample testing process, so that the sample analyzer performs sample testing on the sample while maintaining the component to be maintained.
When the sample analyzer acquires a sample test instruction, if the sample analyzer is detected to execute the first maintenance process, the sample analyzer is controlled to stop the first maintenance process and perform mechanical reset, and then the sample analyzer is controlled to execute the second maintenance process and the sample test process simultaneously, so that the requirement of the sample on the follow-up test is met, and the normal execution of the maintenance process can be ensured.
Referring to fig. 4, a method for maintaining a sample analyzer is described in detail below based on the embodiment shown in fig. 3, and another embodiment of the method for maintaining a sample analyzer in the embodiment of the present application includes:
controlling the sample analyzer to execute a first maintenance process to maintain the component to be maintained, wherein the first maintenance process comprises:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a magnetic separation unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup and place the reaction cup on a preset hole position of the reaction disc;
and step 3: the reaction disc is controlled to position the preset hole position to a rear operation position, so that the grabbing and transferring mechanism can place the reaction cup into the magnetic separation disc of the magnetic separation unit;
and 4, step 4: controlling the magnetic separation disc to move so as to convey the reaction cup to a position below a first liquid injection needle of the magnetic separation disc, and controlling the first liquid injection needle to inject a preset amount of cleaning liquid into the reaction cup;
and 5: controlling the magnetic separation disc to move so as to convey the reaction cup after liquid injection to the lower part of the first liquid suction needle, and starting magnetic separation liquid suction to complete cleaning of the first liquid suction needle;
step 6: sequentially conveying the reaction cups to the positions below the residual liquid injection needles and the residual liquid suction needles in the magnetic separation disc to complete cleaning of the residual liquid suction needles;
and 7: controlling the magnetic separation disc to move so as to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup;
and if the sample analyzer detects a sample test instruction after executing the action instruction in the step 5 in the first maintenance process, controlling a reaction cup loading mechanism, a sample unit, a sample dispensing mechanism, a reagent unit, a reagent dispensing mechanism, the reaction disc, a blending mechanism, a measuring unit, the magnetic separation unit, a waste liquid sucking unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset, and controlling the sample analyzer to execute a second maintenance process after the mechanical reset is completed, wherein in the process of executing the mechanical reset on the magnetic separation disc, the controller controls the magnetic separation disc to move because the magnetic separation disc is provided with a reaction cup, so that the reaction cup is positioned to a rear operation position, and the grabbing and transferring mechanism discards the reaction cup.
Wherein the second maintenance procedure comprises:
step 1: controlling the grabbing and transferring mechanism to grab a reaction cup from the reaction cup loading mechanism to the sample loading position of the reaction tray;
step 2: controlling the sample dispensing mechanism to suck a sample from the sample unit, and then discharging the sucked sample to a reaction cup at the sample adding position;
it should be noted that, since the sub-operations in the second maintenance flow are the same as those in the sample testing flow, and the sample is not actually required to be added in the second maintenance flow, the sample dispensing mechanism in the embodiment of the present application sucks an empty sample from the sample cell, and discharges the empty sample into the cuvette at the sample addition site.
In practice, the sample may be drawn from the sample cell, but the amount of the sample discharged into the reaction cup at the sample application position is set to 0.
And step 3: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to sample adding to a reagent adding position of the reaction tray;
and 4, step 4: controlling a reagent dispensing mechanism to suck reagent from a reagent unit and then discharge the reagent into a reaction cup in the reagent adding position;
similarly to step 2, in the second maintenance flow, no reagent is actually required, so the reagent dispensing mechanism in the embodiment of the present application sucks empty reagent from the reagent unit, and the reagent discharged to the reaction cuvette at the reagent adding position is also empty reagent.
In practice, the reagent may be drawn from the reagent unit, but the amount of the reagent discharged into the cuvette at the reagent addition site is set to 0.
And 5: controlling the grabbing and transferring mechanism to convey the reaction cups added with the reagents to the mixing mechanism for mixing uniformly;
step 6: controlling the grabbing and transferring mechanism to convey the reaction cups in the blending mechanism to a post-operation position of the reaction tray for incubation;
and 7: after the incubation is finished, controlling the grabbing and transferring mechanism to convey the reaction cups at the post-operation position to the magnetic separation unit for magnetic separation and cleaning;
and 8: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to the magnetic separation cleaning to the measuring unit for measurement;
and step 9: controlling the grabbing and transferring mechanism to convey the measured reaction cup to a waste liquid absorption level in the reaction disc, so that the waste liquid absorption unit absorbs the reaction liquid in the reaction cup after the test is finished;
step 10: and controlling the grabbing and transferring mechanism to convey the reaction cups with the waste liquid suction levels to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cups from the rear operation position.
In the embodiment of the application, the process of switching from the first maintenance flow to the second maintenance flow is described in detail, so that the feasibility of switching the first maintenance flow to the second maintenance flow of the sample analyzer is improved.
It is clear to those skilled in the art that, for convenience and brevity of description, the specific working processes of the above-described systems, apparatuses and units may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.
In the several embodiments provided in the present application, it should be understood that the disclosed system, apparatus and method may be implemented in other manners. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
In addition, functional units in the embodiments of the present invention may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (15)
1. A sample analyzer, comprising at least:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the blending mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
the controller is used for controlling the sample analyzer to be switched from a first maintenance mode to a second maintenance mode if a sample testing instruction is detected when the sample analyzer executes a first maintenance process;
wherein if the sample analyzer is in the first maintenance mode, the controller controls the sample analyzer to execute the first maintenance procedure;
and if the sample analyzer is in the second maintenance mode, the controller controls the sample analyzer to execute a second maintenance process and simultaneously execute a sample testing process.
2. The sample analyzer of claim 1, wherein the second maintenance procedure has at least more control commands to the waste aspiration unit and to the reagent unit than the first maintenance procedure.
3. The sample analyzer of claim 2, wherein the waste aspiration unit comprises at least a waste aspiration needle and a waste pump, and the reagent unit comprises a reagent tray;
the control instruction for the waste liquid suction unit specifically comprises: controlling the waste liquid sucking needle and the waste liquid pump to suck the reaction liquid in the reaction cup after the test is finished;
the control instruction for the reagent unit specifically includes: and controlling the reagent disk to uniformly mix the magnetic bead reagent.
4. The sample analyzer of claim 1, wherein the second maintenance procedure comprises a plurality of maintenance cycles, and the sample testing procedure comprises one testing cycle;
the controller controls the test cycle and at least one of the maintenance cycles to be performed simultaneously while the sample analyzer is in the second maintenance mode.
5. The sample analyzer of claim 4, wherein the maintenance cycle is divided into a plurality of target time periods, each target time period performing one or more maintenance sub-actions, and the test cycle is divided into a plurality of target time periods, each target time period performing one or more test sub-actions;
the controller controls the test period and at least one maintenance period to be performed simultaneously, and comprises the following steps:
the controller controls the sample analyzer to simultaneously perform a test sub-action and a maintenance sub-action of at least one maintenance cycle for at least one target time period.
6. The sample analyzer of claim 5,
the maintenance sub-action within the maintenance period is the same as the test sub-action within the test period.
7. The sample analyzer of claim 4,
in the second maintenance mode, one or more blank periods are provided between the plurality of maintenance periods to insert the sample test flow.
8. The sample analyzer of claim 7, wherein one or more blanking periods are provided between each two of the maintenance periods to insert the sample testing procedure.
9. The sample analyzer of claim 1, wherein the second maintenance procedure comprises a plurality of maintenance sub-actions performed in sequence, and the sample testing procedure comprises a plurality of testing sub-actions performed in sequence;
the controller controls the sample analyzer to perform at least one maintenance sub-action and at least one test sub-action simultaneously while the sample analyzer is in the second maintenance mode.
10. The sample analyzer of claim 1 wherein prior to performing the second maintenance mode, the controller is further configured to:
sending out information for prompting a user to execute pre-test preparation on the test reagent;
and/or the presence of a gas in the gas,
and sending out information for prompting the user to perform preparation before maintenance on the maintenance equipment.
11. The sample analyzer of claim 1 wherein prior to performing the second maintenance mode, the controller is further configured to:
and sending information for prompting a user to put a device for bearing the intensified cleaning solution in the reagent unit.
12. The sample analyzer of claim 1 wherein prior to performing the second maintenance mode, the controller is further configured to:
and controlling an execution part in the maintenance process and an execution part in the sample testing process to execute mechanical reset.
13. A method of maintaining a sample analyzer, comprising:
controlling the sample analyzer to execute a first maintenance process to maintain the component to be maintained;
obtaining a sample test instruction;
controlling the sample analyzer to stop executing the first maintenance process and perform mechanical reset;
and controlling the sample analyzer to simultaneously execute a second maintenance process and a sample testing process, so that the sample analyzer performs sample testing on the sample while maintaining the component to be maintained.
14. A method of maintaining a sample analyzer, comprising:
controlling a sample analyzer to perform a first maintenance procedure to maintain a part to be maintained, the first maintenance procedure comprising:
step 1: controlling a reaction cup loading mechanism, a reaction disc, a magnetic separation unit and a grabbing and transferring mechanism in the sample analyzer to execute mechanical reset;
step 2: controlling the grabbing and transferring mechanism to grab the reaction cup and place the reaction cup on a preset hole position of the reaction disc;
and step 3: the reaction disc is controlled to position the preset hole position to a rear operation position, so that the grabbing and transferring mechanism can place the reaction cup into the magnetic separation disc of the magnetic separation unit;
and 4, step 4: controlling the magnetic separation disc to move so as to convey the reaction cup to a position below a first liquid injection needle of the magnetic separation disc, and controlling the first liquid injection needle to inject a preset amount of cleaning liquid into the reaction cup;
and 5: controlling the magnetic separation disc to move so as to convey the reaction cup after liquid injection to the lower part of the first liquid suction needle, and starting magnetic separation liquid suction to complete cleaning of the first liquid suction needle;
step 6: sequentially conveying the reaction cups to the positions below the residual liquid injection needles and the residual liquid suction needles in the magnetic separation disc to complete cleaning of the residual liquid suction needles;
and 7: controlling the magnetic separation disc to move so as to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup;
if the sample analyzer detects a sample test instruction when the sample analyzer executes the action instruction in the step 5 in the first maintenance process, controlling the reaction cup loading mechanism, the sample unit, the sample dispensing mechanism, the reagent unit, the reagent dispensing mechanism, the reaction disk, the blending mechanism, the measuring unit, the magnetic separation unit, the waste liquid suction unit and the grabbing and transferring mechanism in the sample analyzer to execute mechanical reset, and controlling the sample analyzer to execute a second maintenance process after the mechanical reset is completed, wherein in the process of executing the mechanical reset on the magnetic separation unit, the magnetic separation disk is controlled to move so as to position the reaction cup to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cup;
wherein the second maintenance procedure comprises:
step 1: controlling the grabbing and transferring mechanism to grab a reaction cup from the reaction cup loading mechanism to the sample loading position of the reaction tray;
step 2: controlling the sample dispensing mechanism to suck a sample from the sample unit, and then discharging the sucked sample to a reaction cup at the sample adding position;
and step 3: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to sample adding to a reagent adding position of the reaction tray;
and 4, step 4: uniformly mixing reagents in the reagent units, controlling the reagent dispensing mechanism to suck the reagents from the reagent units and then discharging the reagents into reaction cups in the reagent adding positions;
and 5: controlling the grabbing and transferring mechanism to convey the reaction cups added with the reagents to the blending mechanism for blending;
step 6: controlling the grabbing and transferring mechanism to convey the reaction cups in the blending mechanism to a post-operation position of the reaction tray for incubation;
and 7: after the incubation is finished, controlling the grabbing and transferring mechanism to convey the reaction cups at the post-operation position to the magnetic separation unit for magnetic separation and cleaning;
and 8: controlling the grabbing and transferring mechanism to convey the reaction cups subjected to the magnetic separation cleaning to the measuring unit for measurement;
and step 9: controlling the grabbing and transferring mechanism to convey the measured reaction cup to a waste liquid absorption level in the reaction disc, so that the waste liquid absorption unit absorbs the reaction liquid in the reaction cup after the test is finished;
step 10: and controlling the grabbing and transferring mechanism to convey the reaction cups with the waste liquid suction levels to a rear operation position, so that the grabbing and transferring mechanism discards the reaction cups from the rear operation position.
15. A sample analyzer comprising at least:
a reaction cup loading mechanism for supplying and carrying the reaction cup to a predetermined position;
the sample unit is used for bearing a sample;
the sample dispensing mechanism is used for sucking a sample and discharging the sample into a reaction cup positioned at a sample adding position;
the reagent unit is used for bearing a reagent;
the reagent dispensing mechanism is used for sucking the reagent and discharging the reagent into a reaction cup positioned at the reagent adding position;
the reaction disc is arranged in a disc-shaped structure, a plurality of placing positions for placing reaction cups are arranged on the reaction disc, and the reaction disc can rotate and drive the reaction cups in the placing positions to rotate and is used for scheduling the reaction cups in the reaction disc and incubating reaction liquid in the reaction cups;
the blending mechanism is used for blending the reaction liquid to be blended in the reaction cup;
a measuring unit for measuring a reaction solution to be measured;
the magnetic separation unit is used for carrying out magnetic separation and cleaning on the reaction liquid in the reaction cup;
the grabbing and transferring mechanism is used for grabbing the reaction cups and scheduling the reaction cups at least among the reaction cup loading mechanism, the reaction disc, the uniformly mixing mechanism and the magnetic separation unit;
the waste liquid sucking unit is used for sucking the reaction liquid in the reaction cup after the test is finished;
and the controller is used for controlling the sample analyzer to execute a sample test process on the sample to be tested while executing a maintenance process on the part to be maintained.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110758382.4A CN115575650A (en) | 2021-07-05 | 2021-07-05 | Sample analyzer and maintenance method of sample analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110758382.4A CN115575650A (en) | 2021-07-05 | 2021-07-05 | Sample analyzer and maintenance method of sample analyzer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116449037A (en) * | 2023-06-16 | 2023-07-18 | 成都瀚辰光翼生物工程有限公司 | Flow state control method and device for biological detection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116449037A (en) * | 2023-06-16 | 2023-07-18 | 成都瀚辰光翼生物工程有限公司 | Flow state control method and device for biological detection |
| CN116449037B (en) * | 2023-06-16 | 2023-09-12 | 成都瀚辰光翼生物工程有限公司 | Flow state control method and device for biological detection |
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