CN115569681A - Plug-in type reagent tube assembly and nucleic acid self-testing device matched with same - Google Patents
Plug-in type reagent tube assembly and nucleic acid self-testing device matched with same Download PDFInfo
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- CN115569681A CN115569681A CN202211138940.8A CN202211138940A CN115569681A CN 115569681 A CN115569681 A CN 115569681A CN 202211138940 A CN202211138940 A CN 202211138940A CN 115569681 A CN115569681 A CN 115569681A
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 37
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 14
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 14
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 14
- 238000012360 testing method Methods 0.000 title claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 86
- 238000007789 sealing Methods 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims description 67
- 238000000926 separation method Methods 0.000 claims description 31
- 239000012528 membrane Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 108010025899 gelatin film Proteins 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 27
- 238000000034 method Methods 0.000 abstract description 6
- 239000000523 sample Substances 0.000 description 40
- 238000003780 insertion Methods 0.000 description 11
- 230000037431 insertion Effects 0.000 description 11
- 238000010438 heat treatment Methods 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000003321 amplification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 229920006268 silicone film Polymers 0.000 description 3
- 238000012546 transfer Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The invention provides a plug-in type reagent tube assembly and a nucleic acid self-testing device matched with the same, wherein the reagent tube assembly comprises: the sample tube is used for containing a sample and a reagent, and a first end of the sample tube is provided with a sealing cover, and a second end of the sample tube is a closed end; the base is provided with a positioning hole for inserting the second end of the sample tube and at least one reaction hole, and a puncture head with a hollow flow channel is arranged in the positioning hole; when the sample tube is inserted into the positioning hole, the puncture head can puncture the closed end so that the content contained in the sample tube flows into the reaction hole through the hollow flow channel. The sample tube can be connected with the base in an inserting mode, the reaction hole is a component of the reagent tube assembly and is no longer located in a reaction device of the detection equipment, the main body of the detection equipment cannot be polluted, the main body of the detection equipment can be reused, and a user only needs to replace the inserting type reagent tube assembly in the using process, so that the detection and use cost of the user is greatly reduced.
Description
Technical Field
The invention belongs to the technical field of nucleic acid detection equipment design, and particularly relates to a plug-in type reagent tube assembly and a nucleic acid self-testing device matched with the same.
Background
With the improvement of living standards and the development of biotechnology, the pursuit and attention of people to health are more prominent, and meanwhile, with the acceleration of life rhythm of people, time, cost, privacy and the like become the attention of people no matter in work or life, and particularly in the aspect of medical detection, complicated examination, a large amount of result waiting time, high detection cost, even some private detection items and the like in hospitals puzzle people; in order to overcome the foregoing disadvantages, a portable nucleic acid detecting apparatus has appeared in the prior art, which has a small volume and a compact structure, and can be purchased by a user and automatically detected at home, after the sample application of a corresponding reagent tube is completed, the reagent tube is inserted into a reaction device with the detecting apparatus, a sample flows into each reaction well in sequence through a flow channel, and after the reaction is completed, the result is read, and since each reaction well is located in the reaction device of the detecting apparatus, after the current nucleic acid detection of the user is completed, the reaction device is contaminated, so that the detecting apparatus cannot be reused, which increases the detection use cost of the user.
Disclosure of Invention
Therefore, the technical problem to be solved by the present invention is to provide a plug-in type reagent tube assembly and a nucleic acid self-testing device used in combination with the same, so as to overcome the defects that in the prior art, a reaction hole is located in a reaction device of a detection device, and the detection device is contaminated after completing a nucleic acid detection, so that the detection device cannot be reused, and the detection use cost of a user is increased.
In order to solve the above problems, the present invention provides a plug-in type reagent tube assembly comprising:
the sample tube is used for containing a sample and a reagent, and a first end of the sample tube is provided with a sealing cover, and a second end of the sample tube is a closed end;
the base is provided with a positioning hole for inserting the second end of the sample tube and at least one reaction hole, and a puncture head with a hollow flow channel is arranged in the positioning hole;
when the sample tube is inserted into the positioning hole, the puncture head can puncture the closed end so that the content contained in the sample tube flows into the reaction hole through the hollow flow channel.
In some embodiments, the base comprises:
fixed disk and reaction seat, the fixed disk with the mutual lock of reaction seat is connected, the locating hole structure in on the fixed disk, still including dividing the liquid dish, the puncture head connect in divide on the liquid dish, divide to have on the liquid dish and divide the liquid runner, divide the one end of liquid runner with cavity runner intercommunication, divide the other end of liquid runner with the reaction hole intercommunication.
In some embodiments, the liquid separation disc further has a flow guiding column extending into the reaction hole, and the liquid separation flow channel is communicated with the reaction hole through the flow guiding column.
In some embodiments, the liquid separation flow channel is an open groove configured on the bottom end face of the liquid separation disc, and the base further comprises a sealing film sandwiched between the reaction seat and the bottom end face of the liquid separation disc to form a seal against the opening of the open groove.
In some embodiments, the sealing membrane is a silicone membrane, the liquid separation flow channel has a plurality of liquid separation flow channels, the first ends of the plurality of liquid separation flow channels are communicated with the hollow flow channel, the second ends of the plurality of liquid separation flow channels are respectively communicated with one reaction hole, and the first ends of the liquid separation flow channels can be plugged or conducted by the silicone membrane in a controllable manner.
In some embodiments, a first hemispherical groove is configured at a central position of the liquid separation disc, the first ends of the plurality of liquid separation flow passages are located on a groove wall of the first hemispherical groove, a second hemispherical groove is provided on the silicone membrane, the second hemispherical groove is opposite to the first hemispherical groove, and a through hole is configured at a position of the reaction seat corresponding to the second hemispherical groove.
In some embodiments, the top surface of the fixed disk is provided with first elastic buckles, at least two first elastic buckles are arranged at intervals around the positioning hole, and the outer circumferential wall of the second end of the sample tube is provided with first clamping grooves matched and clamped with the first elastic buckles; and/or, the bottom surface of fixed disk is provided with second elasticity buckle, at least two second elasticity buckle encircles the fixed disk interval sets up, have on the outer circumferential wall of reaction seat with the second draw-in groove of second elasticity buckle cooperation joint.
In some embodiments, the liquid separation disc is provided with vent holes, the number of the vent holes is the same as that of the reaction holes, and the vent holes correspond to the reaction holes one by one, the fixed disc is provided with air passing holes, and air passing plugs are arranged in the air passing holes; and/or a positioning pin is arranged between the fixed disc and the reaction seat.
In some embodiments, the reaction seat further has a fool-proof structure; and/or the fixed disc is provided with an upwards-raised inserting column, the inserting column is fixedly connected with the puncture head, and the second end of the sample tube is provided with an inserting hole which is matched with the inserting column in an inserting manner; and/or the reaction hole protrudes out of the seat body plane of the reaction seat and extends downwards.
The invention also provides a nucleic acid self-testing device which is used together with the plug-in type reagent tube component.
The invention provides a plug-in type reagent tube assembly and a nucleic acid self-testing device matched with the same, wherein a sample tube can be connected with a base in a plug-in mode, in the process of plug-in connection of the sample tube and the base, a puncture head can puncture the closed end of the sample tube so that the content in the sample tube flows into a reaction hole with a certain volume, and the reaction hole is a component of the reagent tube assembly and is not in the reaction device of a detection device any more, so that the main body of the detection device cannot be polluted.
Drawings
FIG. 1 is a schematic diagram of the internal structure of a plug-in reagent tube assembly according to an embodiment of the present invention;
FIG. 2 is a schematic view of the structure of the sample tube of FIG. 1;
FIG. 3 is a schematic perspective view of the fixing plate of FIG. 1;
FIG. 4 is a schematic perspective view of the reaction socket of FIG. 1;
fig. 5 is a schematic view of the internal structure of the distribution plate of fig. 1.
The reference numbers are given as:
1. a sample tube; 11. a sealing cover; 12. a first card slot; 13. inserting holes; 21. a puncture head; 22. fixing the disc; 221. a first elastic buckle; 222. a second elastic buckle; 223. air passing holes; 23. a reaction seat; 231. a reaction well; 232. a through hole; 233. a second card slot; 234. positioning pins; 235. a fool-proof structure; 24. a liquid separating disc; 241. a flow guide column; 242. a first hemispherical recess; 243. inserting the columns; 244. a vent hole; 25. a sealing film; 251. a second hemispherical recess.
Detailed Description
Referring collectively to fig. 1-5, according to an embodiment of the present invention, there is provided a plug-in reagent tube assembly comprising: the sample tube 1 is used for containing a sample and a reagent, and is provided with a sealing cover 11 at a first end and a closed end at a second end; a base having a positioning hole for inserting the second end of the sample tube 1 and at least one reaction hole 231 therein, the positioning hole having a puncture head 21 (which may be a puncture needle) with a hollow flow channel therein; when the sample tube 1 is inserted into the positioning hole, the puncture head 21 can puncture the closed end so that the content (i.e. the mixed liquid of the sample and the reagent) contained in the sample tube 1 flows into the reaction hole 231 through the hollow flow channel. In the technical scheme, the sample tube 1 can be connected with the base in an insertion mode, in the process of inserting the sample tube 1 and the base, the puncture head 21 can puncture the closed end of the sample tube 1, so that the content in the sample tube 1 flows into the reaction hole 231 with a certain volume, and the reaction hole 231 is a component part of the reagent tube assembly and is not in a reaction device of the detection equipment any more, so that the main body of the detection equipment cannot be polluted, the detection equipment can be reused, in the using process, a user only needs to replace the insertion type reagent tube assembly, the detection using cost of the user is greatly reduced, and what needs to be particularly explained is that the insertion type reagent tube assembly only needs to be sampled by the user and then is inserted and connected with the base after the sample is placed in the sample tube 1, so that the quantitative transfer of the sample into the reaction hole 231 can be realized, and finally the insertion type reagent tube assembly is placed on the detection equipment main body to carry out subsequent steps of heating, amplification, detection and the like, and the like without the processes of special pipetting, so that the operation is very simple and convenient, and is particularly suitable for self-detection, further can meet the private scene of a large amount of protection of the user, and the waiting time can be saved. The sealing cap 11 is provided with a venting hole and is covered with a venting film by ultrasonic or hot melting to ensure that the contents of the sample tube 1 can smoothly enter the reaction hole 231 through the puncture head 21 in a sealed state (i.e. the sealing cap 11 is in a sealed state).
Referring to fig. 1, the base includes a fixing plate 22 and a reaction seat 23, the fixing plate 22 and the reaction seat 23 are fastened together, that is, are assembled in an up-and-down stacked manner, so as to be able to implement assembly and corresponding operation of components (such as a liquid distribution plate 24) disposed therein, the positioning hole is configured on the fixing plate 22, the base further includes a liquid distribution plate 24, the puncture head 21 is connected to the liquid distribution plate 24, the liquid distribution plate 24 has a liquid distribution channel, one end of the liquid distribution channel is communicated with the hollow channel, and the other end of the liquid distribution channel is communicated with the reaction hole 231, so as to implement smooth transfer and guide of contents in the sample tube 1 to the reaction hole 231. Furthermore, the liquid separation disc 24 further has a flow guiding column 241 extending into the reaction hole 231, and the liquid separation flow channel is communicated with the reaction hole 231 via the flow guiding column 241. In this technical scheme, the flow guide pillar 241 extends into the reaction hole 231, preferably into the bottom of the reaction hole 231, so as to prevent the sample solution from forming a pressure difference with the bottom at the inlet of the reaction hole 231 to cause that the liquid cannot fill the whole reaction hole 231 and cannot achieve the quantitative purpose.
In a specific embodiment, referring to fig. 5, the liquid separation flow channel is an open slot configured on the bottom end surface of the liquid separation disc 24, the base further includes a sealing film 25, the sealing film 25 is clamped between the reaction seat 23 and the bottom end surface of the liquid separation disc 24 to seal the opening of the open slot, the liquid separation flow channel is formed by adopting the open slot, the processing difficulty of the liquid separation flow channel can be reduced, and the sealing film 25 can ensure the sealing performance of the liquid separation flow channel.
In some embodiments, the sealing film 25 is a silicone film, so that the sealing film 25 has elastic deformation capability, the liquid separation flow channel has a plurality of liquid separation flow channels, the first ends of the plurality of liquid separation flow channels are communicated with the hollow flow channel, the second ends of the plurality of liquid separation flow channels are respectively communicated with one reaction hole 231, the first ends of the liquid separation flow channels can be plugged or conducted by the silicone film in a controllable manner, namely plugging and conducting of the liquid separation flow channels can be realized by controlling deformation of the silicone film, so that an internal sealing environment is maintained in a detection process or amplification of a sample liquid in the reaction holes 231, and pollution to an external environment is prevented. In one embodiment, the liquid distribution plate 24 is formed with a first hemispherical recess 242 at a central position, the first ends of the plurality of liquid distribution channels are located on the wall of the first hemispherical recess 242, the silicone membrane is formed with a second hemispherical recess 251, the opening of the second hemispherical recess 251 faces upward, the second hemispherical recess 251 is opposite to the first hemispherical recess 242, and the reaction seat 23 is formed with a through hole 232 at a position corresponding to the second hemispherical recess 251. In the technical scheme, an approximately spherical accommodating space is formed between the first hemispherical groove 242 and the second hemispherical groove 251, a freeze-drying reagent can be preset in the accommodating space, and when subsequent operations such as nucleic acid amplification and the like need to be performed, the bottom surface of the second hemispherical groove 251 can be forced to deform upwards by an ejection component such as an ejector rod on a corresponding detection equipment main body and finally attached to the groove wall of the first hemispherical groove 242, so that the liquid separation flow channel is blocked.
As shown in fig. 3, the top surface of the fixed disk 22 is provided with first elastic fasteners 221, at least two first elastic fasteners 221 are arranged at intervals around the positioning hole, the outer circumferential wall of the second end of the sample tube 1 is provided with first clamping grooves 12 engaged with the first elastic fasteners 221, the first clamping grooves 12 may be, for example, annular grooves arranged around the tube body of the sample tube 1, or may be a single plurality of grooves, the invention is not particularly limited, and the fast, convenient and reliable connection between the sample tube 1 and the base is realized through the fastening connection relationship between the first elastic fasteners 221 and the first clamping grooves 12.
The bottom surface of the fixed disk 22 is provided with second elastic fasteners 222, at least two second elastic fasteners 222 are arranged around the fixed disk 22 at intervals, and the outer circumferential wall of the reaction seat 23 is provided with second clamping grooves 233 matched and clamped with the second elastic fasteners 222, so that the reaction seat 23 and the fixed disk 22 can be assembled quickly and reliably.
Referring to fig. 5, the liquid separation pan 24 is configured with vent holes 244, the number of the vent holes 244 is the same as and corresponds to the number of the reaction holes 231 one by one, the fixed pan 22 is configured with air passing holes 223, and air passing plugs (not shown) are disposed in the air passing holes 223, and the air passing plugs are air-permeable and water-impermeable structures, so that the gas in the reaction holes 231 is smoothly discharged, and the contents in the sample tubes 1 can be smoothly introduced into the reaction holes 231.
The positioning pins 234 are provided between the fixed disk 22 and the reaction seat 23, as shown in fig. 4, two positioning pins 234 are provided, and the two positioning pins 234 are integrally formed with the reaction seat 23, and at this time, corresponding positioning holes are configured on the bottom surface of the liquid distribution disk 24, and the positioning pins 234 and the positioning holes are in insertion fit, so as to realize the position determination of the reaction holes 231 on the liquid distribution disk 24 and the reaction seat 23.
In some embodiments, the reaction seat 23 further has a fool-proof structure 235, and the fool-proof structure 235 is a protrusion protruding from the outer circumferential wall of the reaction seat 23 and can be matched with a corresponding component, such as a heating module, provided on the detection apparatus main body for positioning purpose.
Referring to fig. 5, the fixing plate 22 has an upward protruding insertion column 243, the insertion column 243 is fixedly connected with the puncture head 21, the second end of the sample tube 1 has an insertion hole 13 in insertion fit with the insertion column 243, accurate and quick positioning between the sample tube 1 and the puncture head 21 can be achieved through the insertion hole 13, and connection of the sample tube 1 can be guaranteed to be more reliable.
Referring to fig. 1, the reaction hole 231 protrudes from the base plane of the reaction base 23 and extends downward, so as to be placed in the corresponding heating groove of the heating module to realize multi-surface wrapping, thereby ensuring the temperature adjustment and preservation effects.
According to an embodiment of the present invention, there is also provided a nucleic acid self-testing device for use with the above plug-in reagent tube assembly.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (10)
1. A pluggable reagent tube assembly, comprising:
the sample tube (1) is used for containing a sample and a reagent, and is provided with a sealing cover (11) at a first end and a closed end at a second end;
a base having a locating hole for inserting the second end of the sample tube (1) and at least one reaction hole (231), wherein a puncture head (21) having a hollow flow channel is arranged in the locating hole;
when the sample tube (1) is inserted into the positioning hole, the puncture head (21) can puncture the closed end so that the content contained in the sample tube (1) flows into the reaction hole (231) through the hollow flow channel.
2. The bayonet reagent tube assembly of claim 1, wherein the base comprises:
fixed disk (22) and reaction seat (23), fixed disk (22) with the mutual lock of reaction seat (23) is connected, the locating hole construct in on fixed disk (22), still including dividing liquid dish (24), puncture head (21) connect in divide on liquid dish (24), divide to have on liquid dish (24) to divide liquid runner, divide liquid runner's one end with cavity runner intercommunication, divide liquid runner's the other end with reaction hole (231) intercommunication.
3. The pluggable reagent tube assembly of claim 2, wherein the liquid separation tray (24) further has a flow guiding column (241) protruding into the reaction hole (231), and the liquid separation flow channel communicates with the reaction hole (231) via the flow guiding column (241).
4. The bayonet reagent tube assembly of claim 2,
divide the liquid runner for constructing and be in divide the open slot on the bottom face of liquid dish (24), the base still includes seal membrane (25), seal membrane (25) are pressed from both sides and are located reaction seat (23) with divide between the bottom face of liquid dish (24) with it is right to form sealedly to open the mouth of open slot.
5. The bayonet reagent tube assembly of claim 4,
sealing membrane (25) is the pellosil, divide the liquid runner to have many, many divide the first end of liquid runner with cavity runner intercommunication, second end respectively with a reaction hole (231) intercommunication, divide the liquid runner first end can be for the pellosil shutoff of controlling or switch on.
6. The bayonet reagent tube assembly of claim 5,
a first hemispherical groove (242) is formed in the center of the liquid separating disc (24), the first ends of the liquid separating flow channels are located on the wall of the first hemispherical groove (242), a second hemispherical groove (251) is formed in the silica gel film, the second hemispherical groove (251) is opposite to the first hemispherical groove (242), and through holes (232) are formed in the positions, corresponding to the second hemispherical groove (251), of the reaction seat (23).
7. The bayonet reagent tube assembly of claim 2,
the top surface of the fixed disc (22) is provided with first elastic buckles (221), at least two first elastic buckles (221) are arranged around the positioning hole at intervals, and the outer circumferential wall of the second end of the sample tube (1) is provided with first clamping grooves (12) matched and clamped with the first elastic buckles (221); and/or, the bottom surface of fixed disk (22) is provided with second elasticity buckle (222), at least two second elasticity buckle (222) encircle fixed disk (22) interval sets up, have on the outer circumferential wall of reaction seat (23) with second draw-in groove (233) of second elasticity buckle (222) cooperation joint.
8. The bayonet reagent tube assembly of claim 2,
vent holes (244) are formed in the liquid separating disc (24), the number of the vent holes (244) is the same as that of the reaction holes (231), the vent holes correspond to the reaction holes one by one, vent holes (223) are formed in the fixed disc (22), and vent plugs are arranged in the vent holes (223); and/or a positioning pin (234) is arranged between the fixed disc (22) and the reaction seat (23).
9. The bayonet reagent tube assembly of claim 2,
the reaction seat (23) is also provided with a fool-proof structure (235); and/or the fixed disc (22) is provided with an upwards-protruding plug-in column (243), the puncture head (21) is fixedly connected to the plug-in column (243), and the second end of the sample tube (1) is provided with a plug-in hole (13) which is in plug-in fit with the plug-in column (243); and/or the reaction hole (231) protrudes from the seat body plane of the reaction seat (23) and extends downwards.
10. A nucleic acid self-testing device for use with the plug-in reagent tube assembly of any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211138940.8A CN115569681A (en) | 2022-09-19 | 2022-09-19 | Plug-in type reagent tube assembly and nucleic acid self-testing device matched with same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211138940.8A CN115569681A (en) | 2022-09-19 | 2022-09-19 | Plug-in type reagent tube assembly and nucleic acid self-testing device matched with same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115569681A true CN115569681A (en) | 2023-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211138940.8A Pending CN115569681A (en) | 2022-09-19 | 2022-09-19 | Plug-in type reagent tube assembly and nucleic acid self-testing device matched with same |
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| Country | Link |
|---|---|
| CN (1) | CN115569681A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115851417A (en) * | 2023-02-16 | 2023-03-28 | 季华实验室 | PCR tube, PCR chip, amplification heating device and PCR operation method |
-
2022
- 2022-09-19 CN CN202211138940.8A patent/CN115569681A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115851417A (en) * | 2023-02-16 | 2023-03-28 | 季华实验室 | PCR tube, PCR chip, amplification heating device and PCR operation method |
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