CN115569104A - Hair loss prevention and hair growth composition containing plant extract and application thereof - Google Patents
Hair loss prevention and hair growth composition containing plant extract and application thereof Download PDFInfo
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- CN115569104A CN115569104A CN202111680806.6A CN202111680806A CN115569104A CN 115569104 A CN115569104 A CN 115569104A CN 202111680806 A CN202111680806 A CN 202111680806A CN 115569104 A CN115569104 A CN 115569104A
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- hair
- extract
- composition
- plant extracts
- hair growth
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Abstract
The invention relates to the field of IPC A61K8/00, in particular to a hair loss prevention and hair growth promoting composition containing plant extracts and application thereof. The raw materials of the hair loss preventing and hair growing composition comprise: plant extracts and polypeptides. The anti-hair loss and hair growth composition provided by the invention has the following advantages: the apple fruit cell culture extract, the red clover extract and the acetyl tetrapeptide-3 are adopted to jointly act, so that the hair follicle growth rate is effectively improved, and the scalp blood circulation and the cell proliferation activity are promoted; the composition has strong formula compatibility, strong stability when being applied to hair washing and caring products, and can be stably stored under the conditions of high temperature and low temperature; the composition, together with natural antibacterial conditioning substances such as gentian extract, tetrandra root extract, carrageen crispus extract and the like, improves the use experience of scalp essence, prolongs the hair growth period, strengthens the hair root and hair quality, provides light and refreshing feeling for the hair, and is safe and non-irritant.
Description
Technical Field
The invention relates to the field of IPC A61K8/00, in particular to a hair loss preventing and hair growing composition containing plant extracts and application thereof.
Background
With the increasing working and living pressure and the deterioration of the external environment, the alopecia is not limited to occur in the elderly people any more, and the sick people are obviously young, which becomes a big problem disturbing the physical and mental health of people. Aiming at the problem, a large number of alopecia preventing and hair growing products appear on the market, but the symptoms of the alopecia symptoms are various and are linked with the external environment, genetic genes, immunoregulation and even living habits, and the existing products are difficult to treat the symptoms and the root causes.
Chinese patent CN202010836362.X discloses an anti-dandruff scalp essence containing rose fermentation liquor and its preparation method, which adopts the combined action of rose fermentation liquor and denatured ethanol, aminomethyl propanol and sodium hyaluronate as raw materials to remove dandruff and regulate flora balance.
Chinese patent CN202011052458.3 discloses scalp essence containing ganoderma lucidum sporophore spore powder fermentation liquor and a preparation method thereof, and the ganoderma lucidum sporophore spore powder fermentation liquor and caffeine, hydroxypropyl starch phosphate, menthol and the like act together to regulate scalp microecology and enhance scalp moisture; however, the essence contains various irritant raw materials, and the experience feeling is poor when the essence is used.
Chinese patent CN201810317289.8 discloses a turmeric oil-control, anti-hair loss and hair-growing scalp essence and a preparation method thereof, wherein biota orientalis leaf extract, ginger root extract, dimethylol hydantoin, panthenol and other raw materials are adopted to act to achieve the effects of diminishing inflammation, resisting allergy, removing dandruff and controlling oil.
The prior art still cannot give consideration to the balance between the effects of hair loss prevention and hair growth, safety, no stimulation and cost of the hair washing and caring composition.
Disclosure of Invention
The invention provides the hair loss preventing and growing composition containing the plant extract, solves the problem that the safety, the hair loss preventing effect and the cost of hair washing and caring products in the prior art cannot be considered at the same time, and realizes the hair loss preventing and growing composition which is safe, mild and non-irritant.
In order to solve the above problems, the present invention provides a composition for preventing hair loss and promoting hair growth containing plant extracts, which comprises the following raw materials: plant extracts and polypeptides.
In some preferred embodiments, the plant extract is extracted from a combination of one or more of red clover, ginger, mulberry, camellia oleifera, cacumen biotae, polygonum multiflorum, soapberry, fructus viticis, and apple.
Further preferably, the plant extracts include apple (MALUS DOMESTICA) fruit cell culture extract and apple (MALUS DOMESTICA) fruit cell culture extract.
In some preferred embodiments, the polypeptide comprises a combination of one or more of copper peptide, acetyl hexapeptide-3, palmitoyl pentapeptide-3, acetyl tetrapeptide-5.
Further preferably, the polypeptide is acetyl tetrapeptide-5.
More preferably, the weight ratio of the apple fruit cell culture extract, the red clover extract and the acetyl tetrapeptide-3 is (50-80): (0.03-0.1): (0.03-0.1).
Under the influence of factors such as heredity, inflammation and environment, the problem of alopecia is difficult to eliminate completely, and the problem is a problem which puzzles consumers. In the research process, the invention discovers that the joint action of the plant extract and the polypeptide can activate Wnt signal conduction of scalp, activate the growth of dormant hair follicle and reduce seborrheic alopecia caused by excessive secretion of male hormone. Further, the plant extracts including the apple (MALUS domicitica) fruit cell culture extract and the apple (MALUS domicitica) fruit cell culture extract have the combined action with acetyl tetrapeptide-5 with a bionic structure, can promote the cell proliferation and differentiation activity, conduct a conduction path of signal molecules in the scalp, promote the interaction of hair follicle epithelial cells and stem cells, restore the physiological activity of hair follicles, improve blood circulation, ensure the supply of hair bundle nutrition to the scalp, improve the relative growth rate of the hair follicles, strengthen hair roots and have a remarkable synergistic effect on promoting hair regeneration; in a large number of experimental exploration processes, the effect is found in the weight ratio of the apple fruit cell culture extract, the red clover extract and the acetyl tetrapeptide-3 (50-80): (0.03-0.1): (0.03-0.1) is preferable, and the occurrence of the scalp can be significantly prolonged for a long period of time.
The invention provides an application of a hair loss preventing and growing composition containing plant extracts, wherein the hair loss preventing and growing composition is applied to scalp essence, hair conditioner, hair care essential oil and hair mask.
In some preferred embodiments, the anti-alopecia composition is applied to scalp essence, and the raw materials of the scalp essence comprise, by weight:
phase A: 0.5-5% of lubricant, 0.1-1% of anti-inflammatory agent, 0.01-0.5% of EDTA disodium and the balance of water;
phase B: 1-10% of hair loss prevention and hair growth promoting composition, 0.1-4% of skin conditioner, 0.1-2% of hydroxylated saturated cyclane and 0.1-1% of preservative.
The sum of the weight ratios of the A phase and the B phase is 100 percent.
Further preferably, the raw materials of the scalp essence comprise:
phase A: 2% of lubricant, 0.4% of anti-inflammatory agent, 0.1% of EDTA disodium and the balance of water;
phase B: 4% of hair loss prevention and hair growth promoting composition, 2% of skin conditioner, 0.5% of hydroxylated saturated cyclane and 0.6% of preservative;
the sum of the weight ratios of the A phase and the B phase is 100 percent.
In some preferred embodiments, the lubricant comprises a combination of one or more of glyceryl polyether, polyoxyethylene fatty acid ester, castor oil, petrolatum.
Further preferably, the lubricant is glyceryl polyether-26.
In some preferred embodiments, the anti-inflammatory agent comprises a combination of one or more of natural ingredients, dipotassium glycyrrhizinate, allantoin, bisabolol.
Further preferably, the natural ingredients include one or more of a combination of Chondrus crispus extract, aloe vera extract, hamamelis virginiana extract, chamomile extract, and calendula extract.
Still more preferably, the anti-inflammatory agent is Chondrus CRISPUS extract.
In some preferred embodiments, the conditioning agent comprises one or more of quaternary ammonium salts, silicones and derivatives thereof, hydrolyzed collagen, isopropyl isostearate, sclerotium rolfsii gum, hyssop extract, gentian extract, tetrandra root extract, polyol esters.
Further preferably, the conditioner is a mixture of GENTIANA SCABRA (GENTIANA SCABRA) extract and TETRANDRA (STEPHANIA TETRANDRA) extract.
Synthetic chemicals are usually added into traditional scalp essence to achieve the effects of diminishing inflammation, resisting bacteria and protecting hair, and although the components can quickly clean the scalp, the components can easily stimulate the scalp after long-term use, break the balance of scalp flora, and aggravate scalp inflammation without compensation. At present, quaternary ammonium salt compounds, cationic polymers and the like are mostly added into scalp essence on the market, but the irritation of the quaternary ammonium salt components to the scalp is large, the quaternary ammonium salt components and other components (especially anionic surfactants) are difficult to be compatible in a formula, the problems of particle aggregation and association are easy to occur, effective components cannot be fully exerted, and the stability of the scalp essence is difficult to maintain. The cationic polymer is easy to remain in the middle of the hair strand in the using process, so that the hair strand is heavy and drooped, and the experience feeling is poor in the using process.
The natural plant extract contains rich active substances, can provide nutrient components for hair bundles, can effectively inhibit the growth of harmful bacteria on the scalp, does not contain chemical synthetic reagents, has high safety, and is an effective way for regulating and controlling the growth of scalp hair follicles. However, the natural plant extract has slow effect and long treatment course, and when the addition amount is too high, the existence of high active substances in plant components is limited, the product is easy to have uninhibited physical and chemical property change, and the stability is difficult to keep for a long time scale. A large number of plant extracts are tried, the fact that both the hair loss prevention and care effect and the physicochemical stability of most of the plant extracts are difficult to consider is found, in the research process, the fact that when the anti-inflammatory agent is the Chondrus crispus extract and the skin conditioner is the Gentiana scabra extract and the Stephania tetrandra extract is unexpectedly found, under the synergistic effect of the hair loss prevention and hair growth promotion composition, the obtained scalp essence can effectively improve the physiological activity of hair mother cells, and meanwhile has strong system compatibility, and the scalp essence can keep a stable state under the conditions of high temperature and low temperature without layering and deterioration phenomena.
In some preferred embodiments, the number of hydroxyl groups in the hydroxylated saturated cycloalkane is > 4.
More preferably, the hydroxylated saturated cycloalkane is inositol and has a molecular structure of
In the further research process, the discovery is that when the lubricant is glyceryl polyether-26 and 0.1-2% of hydroxylated saturated cycloparaffin is added, the absorption of active ingredients by the scalp can be improved, the scalp essence is promoted to be dispersed into tiny and fine liquid drops, and the liquid drops are uniformly, lightly and thinly dispersed on the surface of the scalp to form a protective film which can avoid the damage of the external environment to the scalp and reduce the loss of internal nutrient ingredients, the scalp is endowed with fresh and soft experience feeling, the discomfort of stickiness, stuffiness and stagnation caused by the traditional components such as glycerin and silicone oil is solved, the scalp is relieved while the hair is nursed and prevented from falling off, and the hair is plump, smooth and fluffy.
In some preferred embodiments, the preservative is a mixture of glyceryl caprylate, 1, 2-hexanediol, caprylyl hydroxamic acid, ethylhexyl glycerin.
Further preferably, the weight ratio of the glyceryl caprylate, the 1, 2-hexanediol, the caprylyl hydroximic acid and the ethylhexyl glycerin in the preservative is 2.75:75.75:11.5:10; the preservative was sourced from eikon biotechnology, guangzhou.
In some preferred embodiments, the scalp essence is prepared by the steps of:
s1, mixing the phase A raw materials, uniformly stirring at 80-85 ℃, and cooling;
s2, cooling to 45-50 ℃, adding the phase B raw material, uniformly stirring, cooling to 26 ℃, and discharging.
Has the advantages that:
the anti-hair loss and hair growth composition provided by the invention has the following advantages:
(1) The apple fruit cell culture extract, the red clover extract and the acetyl tetrapeptide-3 are adopted to jointly act, so that the hair follicle growth rate is effectively improved, and the scalp blood circulation and the cell proliferation activity are promoted;
(2) The composition has strong formula compatibility, strong stability when being applied to hair washing and caring products, and can be stably stored under the conditions of high temperature and low temperature;
(3) The composition and natural antibacterial conditioning substances such as the gentian extract, the tetrandra root extract, the carrageen crispus extract and the like act together, can stay on the surface of scalp for a long time to play a role, improves the use experience of scalp essence, prolongs the hair growth period, strengthens the hair root and hair quality, provides light and refreshing feeling for the hair, and is safe and non-irritant.
Drawings
FIG. 1 shows the growth of hair follicles in each group in an ex vivo hair follicle assay;
FIG. 2 is a comparison of relative growth rates of groups in ex vivo hair follicle experiments;
FIG. 3 is a graph of hair follicle growth at different times in an ex vivo hair follicle experiment;
FIG. 4.5 sample inhibition in alpha reductase assay;
FIG. 5.5 comparison of mean testosterone peak areas of groups in alpha reductase experiments;
FIGS. 6 to 9: irritation test report of example 2.
Detailed Description
Example 1.
The embodiment provides a hair loss preventing and hair growing composition containing plant extracts, which comprises the following raw materials: plant extracts and polypeptides.
The plant extracts are selected from the group consisting of apple (Malus domicitica) fruit cell culture extract and Trifolium PRATENSE (Trifolium PRATENSE) extract.
The polypeptide is acetyl tetrapeptide-3.
The weight ratio of the apple fruit cell culture extract, the red clover extract and the acetyl tetrapeptide-3 is 60:0.06:0.06.
apple with Latin's scientific name Malussdomestica; the apple fruit cell culture extract is derived from MetaTrix APL-3 product of Shanghai Rainbu Enterprise development Limited; specifically, the product comprises the following components: water: butanediol: apple fruit cell culture extract: wild strawberry fruit extract: wild soybean extract: 1, 2-hexanediol: hydrolyzed collagen was 14.5:20:20:20:20:0.5:5.
the Latin school name of red clover is Trifoliumpratense L; the red clover extract and acetyl tetrapeptide-3 are from Capixyl of Shanghai to Soft chemical Co., ltd TM Producing a product; specifically, the product comprises the following components: water: butanediol: and (3) glucan: acetyl tetrapeptide-3: the red clover extract is 50:49.82:0.12:0.03:0.03.
example 2.
This example provides the use of the hair loss preventing and growing composition comprising plant extracts provided in example 1; the anti-hair loss and hair growth composition is applied to scalp essence, and the scalp essence comprises the following raw materials in percentage by weight:
phase A: 2% of lubricant, 0.4% of anti-inflammatory agent, 0.1% of EDTA disodium and the balance of water;
phase B: the hair loss preventing and hair growing composition provided by the embodiment 1 comprises 5% of hair loss preventing and hair growing composition, 2% of skin conditioner, 0.5% of hydroxylated saturated cyclane and 0.6% of preservative.
The sum of the weight ratios of the A phase and the B phase is 100 percent.
The anti-hair loss and hair growth composition provided by the embodiment 1 is prepared from the following components in parts by weight: 2 MetaTrix APL-3 and Capixyl TM And (4) mixing the products.
The lubricant is glyceryl polyether-26.
The anti-inflammatory agent is Chondrus CRISPUS (Chondrus CRISPUS) extract, and the Latin of Chondrus CRISPUS is named Chondrus CRISPUS and is from Shanghai Bo Xuan Kogyo Co.
The skin conditioner is a mixture of radix Gentianae (GENTIANA SCABRA) extract and radix Stephaniae Japonicae (STEPHANIA TETRANDRA) extract; the weight ratio of the gentian extract to the tetrandra root extract in the skin conditioner is (2.5): 2.5:95, and the solvent is prepared from the following components in a weight ratio of 57.5:37.5 water and propylene glycol, said skin conditioner being from ganery, guan, biotechnology limited.
The Latin chemical name of gentian is Gentianascabra Bunge; stephania tetrandra has the latin school name stephaniatretradras.
The hydroxylated saturated cycloalkane is inositol.
The preservative is a mixture of glyceryl caprylate, 1, 2-hexanediol, caprylhydroxamic acid and ethylhexyl glycerin, wherein the weight ratio of the glyceryl caprylate to the 1, 2-hexanediol to the caprylhydroxamic acid to the ethylhexyl glycerin is 2.75:75.75:11.5:10; the preservative was sourced from eikon biotechnology, guangzhou.
The preparation method of the scalp essence comprises the following steps:
s1, mixing the phase A raw materials, uniformly stirring at 80 ℃, and cooling;
s2, cooling to 48 ℃, adding the B-phase raw material, uniformly stirring, cooling to 26 ℃, and discharging.
Performance testing
In vitro hair follicle testing
1. Experimental materials:
1.1 mouse whisker Hair follicle
1.2 culture solution: williams' E serum-free medium (Gibco, lot: 2066552) containing 2mM L-glutamine, 10. Mu.g/mL bovine insulin, 10ng/mL hydrocortisone, 100U/mL penicillin, 100. Mu.g/mL streptomycin
1.3 control group: culture solution
1.4 Positive group: using culture solution to prepare minoxidil liniment with concentration of 10 μ M, sichuan Mei Da Kanghua pharmaceutical industry Limited
1.5 sample groups: samples (example 2) were prepared at concentrations of 70mg/mL,7mg/mL,0.7mg/mL using the culture broth.
2. The test steps are as follows:
2.1 isolating hair follicles: c57BL/6 mice were sacrificed humanely, bilateral whiskers were cut off, the upper lips were sterilized with 75% ethanol 3 times, bilateral whisker pads were cut off and placed in 1:1 (volume) of HBSS: PBS (100U/mL penicillin, 100. Mu.g/mL streptomycin in PBS), and mixing the mixture with 1:1 (volume) of HBSS: PBS was washed 3 times, connective tissue around the hair follicle was carefully removed under a dissecting microscope, the hair follicle was bluntly separated from the surrounding tissue with microsurgical forceps in the direction of the hair follicle, the distal end of the hair follicle was gently grasped, the hair was carefully pulled out of the subcutaneous tissue, and the separated hair follicles were placed in different wells of a 24-well plate.
2.2 Hair follicle culture: at 37 ℃ C, 5% CO 2 Incubate for 14 days under conditions, containing 0.5mL of medium per well.
2.3 sample adding: adding samples on the next day of culture, adding culture medium containing samples with different concentrations into corresponding holes, arranging 8 multiple holes in each group, placing 2-3 isolated hair follicles in each hole, and changing the liquid once every 3 days.
2.4 image analysis: whisker hair follicle length was photographed on days 1 and 14, and morphologically observed and measured.
3. And (3) data analysis:
data are presented as mean ± standard deviation. The relative growth rate of the hair follicle was calculated using the following formula:
hair follicle relative growth rate (%) = (average hair follicle length per group (D14) -average hair follicle length per group (D0))/(hair follicle length in control group (D14) -hair follicle length in control group (D0)) × 100
4. Test results
See fig. 1-3.
Compared with a control group, the hair follicle relative growth rate of the positive group is statistically different (p is less than 0.05); compared with the control group, the sample group has statistical difference (p < 0.05) of the relative growth rate of hair follicles of 70mg/mL and 7mg/mL, and under the experimental condition, the sample of the example 2 has certain effect on promoting the hair growth at the concentration of 70mg/mL and 7mg/mL.
Second, 5. Alpha. Reductase assay
1. Experimental Material
1.1 type II 5 α -reductase: extracted from rat prostate tissue and stored at-80 deg.C
1.2 Positive Control (PC): finasteride 0.4. Mu.M
1.3 sample preparation (TA): the samples (example 2) were diluted with Phosphate Buffered Saline (PBS) at the concentrations tested 100%,50%,30%,10% (note: volume concentration)
1.4 blank: phosphate Buffer (PBS)
2. Experimental procedure
2.1 preparation of type II 5 α -reductase: 10 male rats were taken, fasted overnight, cervical-free and sacrificed by removal of the cervical spine, prepared with pre-cooled buffer at 0 ℃ in a glass homogenizer to 1: homogenizing 5 (by mass), centrifuging 3000g for 10min, centrifuging 10000g of supernatant for 45min, and packaging the supernatant into EP tubes with 1mL per tube to obtain enzyme extract, and storing in refrigerator at-80 deg.C.
2.2 type II 5 α -reductase Activity assay: the reaction system contained 0.25mL of phosphate buffer, 0.70mL of enzyme extract, 0.1mL of testosterone solution (0.5 mg/mL), 0.35mL of NADPH solution (1 mg/mL), and 0.6mL of 10% ethanol (0.4. Mu.M finasteride in the positive control tube and solution in the sample tube). Replacing the enzyme extract with phosphate buffer solution in the control tube, and adding 2.0mL of dichloromethane to stop the reaction; the sample tube reacts at 37 ℃ for 30min, 2.0mL of dichloromethane is added after the reaction is finished to stop the reaction, and the sample tube is shaken for 1min and then centrifuged at 3000r/min for 10min. The upper aqueous phase was removed, 1.0mL of the organic phase was removed and evaporated to dryness, the residue was dissolved in 1.0mL of methanol and the area of the testosterone peak (T) was determined by high performance liquid chromatography. Each reaction was set up with 3 parallel channels.
2.3 analysis of results
Inhibition ratio (%) = (T) Sample tube -T Reaction tube )/(T Control tube -T Reaction tube )×100
2.4 results of the experiment
See fig. 4-5.
2.5 conclusion of the experiment
The sample (example 2) was found to significantly inhibit type II 5. Alpha. -reductase activity at concentrations of 100%,50%,30%, 10%.
3. Stability test
The scalp essence provided in example 2 was placed at-10 ℃ for 30 days, then placed at 45 ℃ for 30 days, and taken out and returned to room temperature, and no difference between the physical and chemical conditions of the sample and the initial state, delamination, precipitation, and discoloration were observed.
4. Irritation test
The scalp essence obtained in example 1 was subjected to irritation test, and the test report is shown in fig. 6 to 9; the polypeptide scalp care essence for the plant cultivation of the test object is specifically the scalp essence provided in example 2.
Claims (10)
1. A hair loss preventing and hair growing composition containing plant extracts is characterized by comprising the following raw materials: plant extracts and polypeptides.
2. The composition for preventing hair loss and growing hair according to claim 1, wherein the plant extract is extracted from one or more of red clover, ginger, mulberry, camellia oleifera, cacumen biotae, fleece-flower root, soapberry, fructus viticis and apple.
3. The composition for preventing hair loss and promoting hair growth containing plant extracts as claimed in claim 2, wherein the plant extracts comprise apple extract and red clover extract.
4. The use of the anti-hair loss and hair growth composition containing the plant extract according to any one of claims 1 to 3, wherein the anti-hair loss and hair growth composition is applied to scalp essence, hair conditioner, hair care essential oil and hair mask.
5. The use of the composition for preventing alopecia and promoting hair growth containing plant extracts as claimed in claim 4, wherein the composition for preventing alopecia is applied to scalp essence, and the raw materials of the scalp essence comprise, by weight:
phase A: 0.5-5% of lubricant, 0.1-1% of anti-inflammatory agent, 0.01-0.5% of EDTA disodium and the balance of water;
phase B: 1-10% of hair loss prevention and hair growth promoting composition, 0.1-4% of skin conditioner, 0.1-2% of hydroxylated saturated cyclane and 0.1-1% of preservative.
The sum of the weight ratios of the A phase and the B phase is 100 percent.
6. The use of the composition for preventing hair loss and promoting hair growth containing plant extracts as claimed in claim 5, wherein the lubricant comprises one or more of glyceryl polyether, polyoxyethylene fatty acid ester, castor oil, and vaseline.
7. The use of the composition for preventing alopecia and promoting hair growth containing plant extracts as claimed in claim 5 or 6, wherein the anti-inflammatory agent comprises one or more of natural ingredients, dipotassium glycyrrhizinate, allantoin, and bisabolol.
8. The use of the anti-alopecia and hair-growing composition containing plant extracts as claimed in claim 7, wherein the natural ingredients comprise one or more of a combination of Chondrus crispus extract, aloe vera extract, hamamelis virginiana extract, chamomile extract, and calendula extract.
9. The use of the composition for preventing alopecia and promoting hair growth containing plant extracts as claimed in any one of claims 5-8, wherein the skin conditioner comprises one or more of quaternary ammonium salt, polysiloxane and its derivatives, hydrolyzed collagen, isopropyl isostearate, sclerotium rolfsii gum, hyssop extract, gentian extract, tetrandra root extract, and polyol ester.
10. The use of the composition for preventing alopecia and promoting hair growth containing plant extracts as claimed in any one of claims 5 to 9, wherein the number of hydroxyl groups in the hydroxylated saturated cycloalkane is > 4.
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| CN112691064A (en) * | 2021-01-28 | 2021-04-23 | 科丝美诗(中国)化妆品有限公司 | Anti-hair loss plant extract and preparation method and application thereof |
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| KR101267198B1 (en) * | 2012-08-15 | 2013-05-27 | 김진옥 | A method which manufactures shampoo for preventing loss of hair and promoting growth of hair |
| CN109846765A (en) * | 2017-11-30 | 2019-06-07 | 赵茹伊 | A kind of hair tonic essence |
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| CN116370589A (en) * | 2023-02-22 | 2023-07-04 | 深圳津梁生活科技有限公司 | Preparation method and application of hair-loss prevention hair-growing composition |
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