CN115554334A

CN115554334A - Caries preventing coating agent capable of being applied to teeth and having relieving effect and preparation method thereof

Info

Publication number: CN115554334A
Application number: CN202211167254.3A
Authority: CN
Inventors: 孙怀庆; 郭朝万; 郑娟; 胡露; 吴铭杰; 肖湲
Original assignee: Best Pharmaceutical Guangzhou Co ltd; Guangdong Marubi Biological Technology Co Ltd
Current assignee: Best Pharmaceutical Guangzhou Co ltd; Guangdong Marubi Biological Technology Co Ltd
Priority date: 2022-09-23
Filing date: 2022-09-23
Publication date: 2023-01-03

Abstract

The application relates to the field of medical appliances, in particular to an anti-caries film coating agent which can be applied to teeth and has a relieving effect and a preparation method thereof. Comprises 30-80% of film forming material according to weight percentage; 0.001% -1% of magnolia bark extract; 12% -25% of volatile solvent; 0.5 to 5 percent of suspending agent; the balance being a fluorine source; the coating agent for preventing dental caries contains no water. The magnolia officinalis extract is cooperatively matched with the volatile solvent, the suspending agent and the fluorine source, on one hand, the concentration of fluoride can be reduced under the condition of achieving the synergistic anti-caries effect, so that the stimulation of the high-concentration fluoride to soft tissues such as gum, oral mucosa and the like and the acute fluorosis in body tissues are reduced, on the other hand, the magnolia officinalis extract has an excellent anti-inflammatory effect, the inflammatory reaction of the fluoride to the soft tissues such as gum, oral mucosa and the like can be reduced, and on the other hand, the inflammatory reaction in the oral cavity can be continuously reduced due to the long-acting slow release effect of the anti-caries film coating agent, so that the long-acting anti-caries effect and the oral cavity soothing effect are achieved.

Description

Caries preventing coating agent capable of being applied to teeth and having relieving effect and preparation method thereof

Technical Field

The application relates to the field of medical appliances, in particular to an anti-caries coating agent which can be applied to teeth and has a relieving effect and a preparation method thereof.

Background

Dental caries is a disease in which hard tooth tissues are destroyed chronically under the influence of multiple factors mainly including bacteria, and is one of common diseases and frequently encountered diseases of oral cavity. Among the morbidity of various diseases, caries is at the forefront. The caries process is a process of demineralization of tooth enamel and dentin under the action of various cariogenic factors, namely, hydroxyapatite which is the main inorganic component of the tooth enamel or the dentin is dissolved under the action of acid, so that enamel mineral substances are lost.

A large number of studies show that the application of fluoride ions to teeth locally can improve the demineralization resistance of hard tissues of the teeth and reduce the occurrence of caries. There are three main aspects of the anticaries mechanism of topical application of fluoride ions: (1) The released fluoride ions can diffuse into the enamel or the dentin through the micropore structure in the enamel or the dentin structure to replace partial hydroxyl of hydroxyapatite to generate fluorapatite, and the fluorapatite has stronger acid etching capability than the hydroxyapatite, so that the acid etching resistance of the enamel is enhanced; (2) The fluoride ions can be combined with calcium ions in saliva or calcium ions generated by dissolving hard tissues of teeth to generate a calcium fluoride deposition layer on the surface of the teeth, and the deposition layer can be slowly dissolved in an acidic environment later to release fluoride ions to play a role of a fluorine reservoir; (3) The released fluorine ions can also enter dental plaques adhered to the surfaces of teeth, inhibit the growth and metabolism of cariogenic bacteria in the dental plaques and reduce cariogenic factors.

The means for preventing dental caries that are commonly used today are: the fluoride dental caries preventing paint is characterized by comprising the following components of fluoridized drinking water, fluorine-containing toothpaste and mouthwash, fluorine coating and fluorine gel, pit and furrow closing, diet improvement and the like, wherein a fluorine protective paint containing 0.1 percent of silicon fluoride is adopted and is praised as the best fluoride caries preventing mode by WHO, so that the fluoride dental caries preventing paint is the most widely and effectively applied caries preventing means in the world at present.

Fluoride coatings, also known as fluoride varnish (fluoride varnish), are a topical anticaries material that has been developed in the late 60's and early 70's of the 20 th century and which, after application to the tooth surface, adhere to the tooth surface for a period of time (typically several hours to tens of hours). During which time fluoride ions can be released, which can fluoridate the hard dental tissue. The fluoride coating material mainly comprises a film-forming material, fluoride and a volatile solvent. The film forming material mainly comprises beeswax, shellac, gum and other components.

CN103961266B discloses a nano carboxymethyl chitosan sodium fluoride anticarious coating and a preparation method and application thereof, wherein the nano carboxymethyl chitosan fluoride coating is generated by carboxymethyl chitosan nano particles with the characteristics of drug slow release function, bacteriostasis, biocompatibility and the like, a self-acid etching resin adhesive with photocuring performance and corresponding fluoride; firstly, carboxymethyl chitosan is prepared into nanoparticles, and a sodium alginate solution is added in the formation process of the nanoparticles to promote the formation of nanoparticles with concentrated particle size distribution. For example, a coating material in the market takes shellac and white wax as a film forming substrate, ethanol as a solvent and sodium fluoride as fluoride. The coating material has the disadvantages that the requirement for film formation is high, the tooth surface is required to be completely dried for application, the color of the coating material is dark, the tooth becomes yellow after the coating material is coated on the tooth, high-concentration fluorine generates certain stimulation to gum and oral mucosa, inflammatory reaction occurs, and the sensory experience of use is greatly influenced. In addition, the other coating material takes two-component addition type silicon rubber as a film forming substrate and takes sodium fluoride or zinc fluoride as fluoride, the two components are manually mixed before the material is applied, the material can be cured after waiting for a long time after being coated on the surface of teeth, and the coating formed after curing has low hydrophilicity, poor fluorine release and poor caries prevention effect.

The anti-caries film coating agent disclosed by the prior art has the advantages of high operation requirement, strict application condition, slow curing film forming, poor bonding property, large irritation to gum and oral mucosa soft tissue, short time effect, easy pollution and washout by oral saliva in a short time after use, and further influences the action time of the medicine, the anti-caries effect and the product experience.

Furthermore, the above techniques generally require cleaning and drying the tooth surface in advance during application, and the tooth surface is kept dry after application until the film coating agent is completely dried and solidified to form a film, and normal oral cavity activities such as drinking water and eating after the film coating are limited to different degrees in order to ensure that the film coating does not fall off. The cause of the above-mentioned disadvantages: the filming conditions of the film coating agent are different, most of the film coating agent is sensitive to water, and saliva in the oral cavity can influence the film forming effect, so that the adhesion tightness of the film coating agent to teeth is influenced, and finally the anti-caries effect is influenced.

Further, most of the above techniques rely on high concentrations of fluoride only to prevent dental caries, but the high concentrations of fluoride can cause irritation to the gums and oral mucosa, thereby causing an inflammatory response. Therefore, the application of the fluoride film coating agent requires high operation requirements of doctors, and the application needs to avoid the contact with the gum or oral mucosa as much as possible.

Disclosure of Invention

An object of the embodiments of the present application is to provide a caries preventing coating agent having a soothing effect which can be applied on teeth and a method for preparing the same.

In a first aspect, the present application provides a soothing anticaries film coating for application to teeth comprising, in weight percent:

30% -80% of film forming material; 0.001% -1% of extract; 12% -25% of volatile solvent; 0.5 to 5 percent of suspending agent; the balance being a fluorine source; the anti-caries film coating agent does not contain water;

the film forming material is a resin material; the extract comprises the following components: cortex Magnolia officinalis extract.

The application discloses an anti-caries film coating agent which adopts a film forming material made of a resin material, a magnolia officinalis extract, a volatile solvent, a suspending agent and a fluorine source for cooperative matching, on one hand, the concentration of fluoride can be reduced under the condition of achieving a cooperative and synergistic anti-caries effect, so that the stimulation of high-concentration fluoride to soft tissues such as gum and oral mucosa and acute fluorosis in body tissues are reduced, on the other hand, the magnolia officinalis extract has an excellent anti-inflammatory effect, the inflammatory reaction of the fluoride to the soft tissues such as gum and oral mucosa can be reduced, and on the other hand, the inflammatory reaction in the oral cavity can be continuously reduced due to the long-acting slow release effect of the anti-caries film coating agent, so that the long-acting anti-caries effect and the oral cavity relieving effect are achieved.

Furthermore, the anti-caries film coating agent is not sensitive to water, can be applied to dry and wet tooth surfaces, is quick in film forming and fast in curing, has strong bonding performance with the tooth surfaces after being cured into a film, can be drunk and eaten normally in a short time, is simple to operate, causes less pain to patients, and has a remarkable anti-caries effect.

Furthermore, the volatile solvent and the suspending agent are adopted to ensure that the magnolia officinalis extract, the resin material and the fluoride powder are uniformly dissolved when being compounded, so that the using effect is ensured.

In other embodiments of the present application, the concentration of the fluorine source in the anti-caries plastics agent is from 3mg/ml to 7mg/ml.

In other embodiments of the present application, the fluorine source, magnolia bark extract, resin material are all powders; the average particle size is 0.7-9.0 μm; alternatively, 1.5 μm to 3.0 μm.

In other embodiments of the present application, the fluoride comprises: at least one of sodium fluoride, zinc fluoride, potassium fluoride, stannous fluoride, strontium fluoride, ammonia fluoride, sodium monofluorophosphate and calcium fluoride.

In other embodiments of the present application, the resin material includes: at least one of rosin, copal resin, shellac, polymerized rosin and rosin glyceride.

In other embodiments herein, the volatile solvent comprises at least one of ethanol, a volatile alkane.

In other embodiments herein, the suspending agent comprises at least one of sodium alginate, polyvinyl alcohol, bentonite, kaolin, colloidal silicon dioxide, or aluminum monostearate.

In other embodiments of the present application, the caries prevention coating agent comprises, in weight percent: 0.1% -5% of taste modifier; the taste modifier is at least one of sweetener or essence;

the sweetener comprises at least one of saccharin sodium, sucralose, acesulfame potassium, aspartame, stevioside, mogroside, xylitol, and erythritol;

the essence comprises at least one of strawberry essence, fresh orange essence, hami melon essence, banana essence, juicy peach essence or watermelon essence.

In a second aspect, the present application provides a method of preparing a soothing caries preventing film coating for application to teeth comprising: according to the weight percentage, 30 to 80 percent of film forming material, 0.001 to 1 percent of extract, 12 to 25 percent of volatile solvent, 0.5 to 5 percent of suspending agent and fluorine source are mixed under the anhydrous state.

In other embodiments of the present application, combining 30% -80% of the film-forming material, 0.001% -1% of the extract, 12% -25% of the volatile solvent, 0.5% -5% of the suspending agent, and the fluorine source in an anhydrous state comprises:

mixing 30-80% of film forming material, 0.001-1% of extract, 12-25% of volatile solvent, 0.5-5% of suspending agent and fluorine source by adopting an ultrasonic dispersion mode.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments.

Thus, the following detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

The inventors have found that when caries protection is carried out using fluoride-containing materials, although the protective effect is achieved, irritation is inevitably produced. While the desired protective effect is usually achieved by increasing the fluoride concentration, the increase in fluoride concentration is associated with strong irritation. Resulting in difficulty in use. The inventors have further investigated that fluoride only protects hard tissues (teeth) while at the same time causing strong irritation to soft tissues (gums, etc.). There is thus a need to achieve effective protection against hard tissue while reducing irritation to soft tissue.

Based on the above, the embodiment of the application provides an anti-caries film coating agent with a relieving effect, which can be applied to teeth, and comprises the following components in percentage by weight:

Further, in some embodiments of the present application, the composition comprises, in weight percent:

31% -79% of film forming material; 0.002% -0.999% of extract; 13% -24% of volatile solvent; 0.6 to 4.9 percent of suspending agent.

Further optionally, in some embodiments of the present application, the composition comprises, in weight percent:

35% -75% of film forming material; 0.1% -0.9% of extract; 15% -23% of volatile solvent; 1 to 4 percent of suspending agent.

Illustratively, the method comprises the following steps of: 35%, 36%, 38%, 40%, 45%, 50%, 55%, 60%, 65%, or 70% film-forming material; 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, or 0.9% extract; 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, or 23% volatile solvent; 1%, 2%, 3% or 4% of a suspending agent.

Further, in some embodiments of the present application, the concentration of the fluorine source in the anti-caries film coating is 3mg/ml to 7mg/ml.

Further optionally, in some embodiments herein, the concentration of the fluorine source in the anti-caries film coating is from 3.1mg/ml to 6.8mg/ml. Further optionally, in some embodiments herein, the concentration of the fluorine source in the anti-caries film coating is from 3.5mg/ml to 6.5mg/ml.

Illustratively, the concentration of the fluorine source in the anti-caries plastics agent is 3.5mg/ml, 3.8mg/ml, 4.0mg/ml, 4.2mg/ml, 4.5mg/ml, 4.8mg/ml, 5.0mg/ml, 5.2mg/ml, 5.5mg/ml, 5.8mg/ml, 6.0mg/ml, 6.2mg/ml or 6.5mg/ml.

Further, in some embodiments herein, the fluorine source is a fluoride powder; the average particle size of the fluoride powder is 0.7-9.0 μm; alternatively, 1.5 μm to 3.0 μm.

Illustratively, the average particle size of the fluoride powder is 0.7 μm, 1.0 μm, 2.0 μm, 2.2 μm, 2.3 μm, 2.5 μm, 2.8 μm, 3.5 μm, 4.0 μm, 5.0 μm, 6.0 μm, 7.0 μm, or 8.0 μm.

Further, in some embodiments herein, the fluoride comprises: at least one of sodium fluoride, zinc fluoride, potassium fluoride, stannous fluoride, strontium fluoride, ammonia fluoride, sodium monofluorophosphate and calcium fluoride.

Further, in some embodiments of the present application, the resin material includes: at least one of rosin, copal resin, shellac, polymerized rosin and rosin glyceride.

Further, in some embodiments herein, the volatile solvent comprises at least one of ethanol, a volatile alkane.

Further, in some embodiments herein, the suspending agent comprises at least one of sodium alginate, polyvinyl alcohol, bentonite, kaolin, colloidal silicon dioxide, or aluminum monostearate.

The inventor finds that when the magnolia officinalis extract is compounded with a resin material and fluoride powder, the problem of uneven dissolution exists; by adopting the volatile solvent and the suspending agent, the magnolia officinalis extract is uniformly dissolved when being compounded with the resin material and the fluoride powder, and the using effect is ensured.

Furthermore, the average particle size of cortex Magnolia officinalis extract, resin material, and fluoride powder is 0.7-9.0 μm.

Within the particle size range, the dissolution uniformity of the whole compound is further ensured.

Further, in some embodiments herein, the caries prevention coating comprises, in weight percent: 0.1% -5% of taste modifier; the taste modifier is at least one of sweetener or essence;

Some embodiments of the present application provide a method for preparing an anti-caries plastics, comprising:

according to the weight percentage, 30 to 80 percent of film forming material, 0.001 to 1 percent of extract, 12 to 25 percent of volatile solvent, 0.5 to 5 percent of suspending agent and fluorine source are mixed under the anhydrous state.

Further, in some embodiments herein, mixing 30% to 80% of the film-forming material, 0.001% to 1% of the extract, 12% to 25% of the volatile solvent, 0.5% to 5% of the suspending agent, and the fluorine source in an anhydrous state comprises:

Illustratively, in some embodiments of the present application, a method for preparing an anti-caries film coating includes the steps of:

(1) Taking fluoride micro powder with the average particle size of 0.7-9.0 μm for later use, crushing the resin material to pass through a 20-100 mesh sieve for later use, and using the colloidal suspending agent for later use.

(2) Taking the resin material according to the proportion of each component, adding the volatile solvent, stirring uniformly, standing until the resin material is completely dissolved, and filtering with 100-300 meshes.

(3) Adding taste modifier and extract into volatile solvent, and dispersing at high speed.

(4) And (3) rapidly and uniformly dispersing the components (2) and (3), adding the fluoride and the colloidal suspending agent obtained in the step (1), and uniformly mixing to obtain the soothing anti-caries film coating agent.

By adopting the method, the prepared film coating agent is ensured to have excellent effects of preventing caries and relieving, and the prepared film coating agent system can be ensured to be dissolved uniformly.

The caries-preventing film coating agent with soothing effect which can be applied on teeth of the present application has the following advantages:

(1) The coating can be tightly adhered to the surface of teeth under the condition that the tooth surface is wet or dry, can be quickly cured into a film without external force, has long adhesion time and is not easy to fall off, and the performance index of the cured coating is far superior to that of a commercial product, for example, the adhesion to the teeth is improved by 60-80%.

(2) Can meet the requirement of release time, and lead the fluoride coating film to slowly release fluoride so as to avoid acute fluoride poisoning. Can release high-concentration fluorine ions for a long time, and has high safety and no cytotoxicity.

(3) The film coating agent can effectively prevent dental caries, enhance acid erosion resistance of teeth, promote tooth remineralization, inhibit reproduction and acid production of cariogenic bacteria, relieve oral diseases such as stomatitis and the like for a long time, and maintain oral health.

(4) The coating agent is different from a novel medicinal high-molecular film forming material of a product on the market through reasonable compounding, the coating agent has good adhesion and is colorless and transparent, the prepared sodium fluoride anti-caries coating agent is safe and attractive, and no psychological burden is caused after the coating agent is applied to teeth.

The features and properties of the present application are described in further detail below with reference to examples:

examples 1 to 5

A caries preventing film coating agent having soothing effect which can be applied to teeth is provided, and its composition is shown in Table 1.

TABLE 1

The preparation method comprises the following steps:

dispersing sodium fluoride with average particle size of 0.7 μm, sucralose, cortex Magnolia officinalis extract and colloidal silicon dioxide in anhydrous ethanol and n-hexane by ultrasonic disperser, adding film-forming materials including rosin glyceride, rosin pentaerythritol ester, polymerized rosin, olibanum and shellac, dissolving completely, adding essence, and continuously dispersing for 3 hr until all components are completely dissolved to obtain the final product.

Experimental example 1

The fluoride coating films of the respective examples were examined for the effect of releasing cumulative fluoride ions within 24 hours.

The experimental procedure was as follows:

a total of 80 polyester chips with a thickness of 0.5mm were cut into square slides with a side length of 10mm, cleaned with ultrasound, dried and weighed on an analytical balance with a sensitivity of 0.0001g and divided into 8 groups of 10 chips each. A thin layer of the anti-caries coating agent prepared in each example was uniformly coated on one side of a polyester slide, immediately weighed, and each coated slide was immersed in a plastic extraction flask containing 5ml of deionized water, one for each extraction flask, covered and placed in a 37 ℃ constant temperature water bath shaker. Slides of both materials were taken 10 each at 3 hours, 7 hours, 12 hours, and 24 hours after immersion from the specimen extraction flask, and then 5.0ml of TISAB was added to each flask of the extract from which the slides were taken, and the concentration of fluoride ions (mg/L) in the extract was measured with a fluoride ion selective composite electrode (type DC219-F, mettler Toledo Co, switzerland) and an ion tester (type SevenMulti, mettler Toledo Co, switzerland) under stirring. And calculating the content of fluorine ions in the leaching solution, and dividing the amount of the released fluorine ions (mg F-) by the corresponding coating film mass (g) to obtain a fluorine release value (mg F-/g). The cumulative fluoride ion release over 24 hours for the fluoride coating films of each example is shown in table 2.

TABLE 2

As is clear from Table 2, the film coating agent of the present application has a particularly long-lasting slow-release effect, ensuring an anticaries effect.

Experimental example 2

Evaluation experiment of antibacterial performance of oral pathogenic bacteria:

oral pathogen bacteriostatic performance evaluation experiments were performed on the above example 2 and comparative example 2.

1. Test method

The liquid shows the bacteriostatic action by the contact of the microorganisms with the bacteriostatic agent in the antibacterial product. The experiment judges whether the bacteriostatic ability is possessed or not according to the bacteriostatic rate.

2. Test equipment

(1) Oral pathogenic bacteria (streptococcus mutans (ATCC 700610), porphyromonas gingivalis (ATCC 33277));

(2) Phosphate buffer (PBS, 0.03mol/L, pH 7.2-7.4);

(3) A triangular flask and a test tube;

(4) Brain heart infusion agar medium (BHIA);

(5) Example 2 and comparative example 2 anti-caries plastics;

3 operating procedure

(1) Respectively adding 90mL of sterile PBS and 10g of the caries-preventing film coating agent of the embodiment 3 and the embodiment 4 into a 250mL sterile triangular flask containing glass beads, and oscillating the triangular flask to fully disperse the caries-preventing film coating agent into a homogenate solution (10%) for later use;

(2) The test bacteria 24h plate culture was washed with PBS to prepare a bacterial suspension (the required concentration was 100. Mu.L of the test bacteria was dropped into 5mL of PBS control solution or 5mL of sample solution, and the number of recovered bacteria was 1X 10 ⁴ CFU/mL～9×10 ⁴ CFU/mL)。

(3) Sucking 3 tubes of sample liquid (5 mL) and control liquid (5 mL), taking the bacterial suspension, respectively dripping 100 mu L of the bacterial suspension into each sample liquid and control sample or sample liquid, uniformly mixing, starting timing, acting for 2min, fully and uniformly mixing, properly diluting, then taking 2-3 dilutions, respectively sucking 1mL, placing in 2 plates, pouring 15mL of BHI culture medium cooled to 40-45 ℃, rotating the plates to fully and uniformly, turning the plates after agar solidification, culturing at 35 +/-2 ℃ for 48h, and counting viable bacteria colonies.

(3) The bacteriostatic rate was calculated as follows:

in the formula: x is the bacteriostatic rate,%; NC is the average colony number of the control sample, CFU/mL; NS is the average colony number of the tested sample, CFU/mL.

(4) Evaluation criteria

The bacteriostasis rate is more than or equal to 50-90 percent, and the product has bacteriostasis; the bacteriostasis rate is more than or equal to 90 percent, and the product has stronger bacteriostasis.

4. The test results are shown in Table 3.

TABLE 3

Group of	Rate of inhibition of bacteria
		Example 2	98％
Comparative example 2	80％

As can be seen from comparison between example 2 and comparative example 2, the caries prevention effect is greatly improved by adding the magnolia bark extract; fluoride release is comparable, but the inhibitory effect on cariogenic bacteria is better.

Experimental example 3

Evaluation experiment of antibacterial performance of oral pathogenic bacteria:

the oral mucosa irritation test evaluation experiment was performed for the above example 2 and comparative example 2.

1.1 materials and methods

1.1 taking 3 male golden hamster qualified for quarantine, soaking a test object and normal saline respectively by using cotton balls with the diameter of 10mm, placing the cotton balls on the buccal mucosa surfaces at two sides of the oral cavity of the golden hamster, taking one side as a test and one side as a control, respectively taking test pieces of samples of example 2 and comparative example 2 and control materials, and carrying out buccal and skin suture by using medical 5-0 suture threads to fix the test pieces on the buccal mucosa surfaces. The force of the suture is such that the test strip is tightly attached to the mucosa, but no pressure is applied, and the animal is sacrificed at 14d after the suture.

1.2 judging the result, according to YY/T0127.12-2009' oral medical appliance biology evaluation unit 2: test methods oral mucosa irritation test "in table 7.1.2 table 1 oral mucosa reaction scoring system, table 7.2.1 table 2 oral mucosa tissue reaction scoring system and table 7.2.4 table 3 oral mucosa tissue reaction grading for result judgment.

2 results of the experiment

Example 2 was very slightly irritating and comparative example 2 was slightly irritating.

The invention shows that after the magnolia bark extract, which is an extract with the effects of preventing caries and resisting inflammation, is added, the caries preventing effect is better (the release of fluoride is equivalent, but the inhibiting effect on cariogenic bacteria is better), and the irritation of the caries preventing film coating agent is greatly reduced.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made to the present application by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An anti-caries film coating with soothing effect for application to teeth, comprising, in weight percent:

30% -80% of film forming material; 0.001% -1% of magnolia bark extract; 12% -25% of volatile solvent; 0.5 to 5 percent of suspending agent; the balance being a fluorine source; the anti-caries film coating agent does not contain water;

the film forming material is a resin material.

2. A soothing effect caries prevention film coating applicable on teeth as claimed in claim 1,

the fluorine source, the magnolia bark extract and the resin material are all powder; the average particle size is 0.7-9.0 μm; alternatively, 1.5 μm to 3.0 μm.

3. A soothing effect caries prevention film coating applicable on teeth as claimed in claim 1,

the resin material includes: at least one of rosin, copal resin, shellac, polymerized rosin and rosin glyceride.

4. A soothing anticaries coating for application to teeth according to any of claims 1 to 3,

the volatile solvent comprises at least one of ethanol and volatile alkane.

5. A soothing anticaries coating for application to teeth according to any of claims 1 to 3,

the suspending agent comprises at least one of sodium alginate, polyvinyl alcohol, bentonite, kaolin, colloidal silicon dioxide or aluminum monostearate.

6. A soothing effect caries preventing coating agent applicable on teeth as claimed in claim 1,

the fluorine source comprises a fluoride; the fluorinated compound comprises: at least one of sodium fluoride, zinc fluoride, potassium fluoride, stannous fluoride, strontium fluoride, ammonia fluoride, sodium monofluorophosphate, and calcium fluoride.

7. A soothing effect caries preventing coating agent applicable on teeth as claimed in claim 6,

in the film coating agent for preventing dental caries, the concentration of the fluorine source is 3mg/ml-7mg/ml.

8. A soothing effect caries prevention film coating applicable on teeth as claimed in claim 1,

the anti-caries coating agent also comprises: at least one of saccharin sodium, sucralose, acesulfame potassium, aspartame, stevioside, mogroside, xylitol and erythritol.

9. A method of preparing a soothing caries preventing coating as claimed in any one of claims 1 to 8 comprising:

10. A method of preparing a soothing anticaries film coating for application to teeth as claimed in claim 9,

mixing 30% -80% of film forming material, 0.001% -1% of extract, 12% -25% of volatile solvent, 0.5% -5% of suspending agent and fluorine source under the anhydrous state, including: