CN115541328A - Sample processing device, sample analyzer, and sample processing method - Google Patents

Abstract

The present invention relates to a sample processing device, a sample analyzer, and a sample processing method. The rod-shaped member is adapted to extend into a sample container for accommodating a sample carrier member to which a sample is adhered and a diluting solution for diluting said sample. The control part is used for controlling the rod-shaped part to extend into the sample container along the central area of the sample container, then controlling the rod-shaped part to move towards the direction close to the side wall of the sample container, and then controlling the rod-shaped part to move towards the bottom of the sample container. When the rod-shaped component is positioned in the sample container, the rod-shaped component moves towards the interior of the sample container to avoid the central area of the sample container and then moves along the direction close to the bottom of the sample container, so that when the rod-shaped component moves to be close to the bottom of the sample container, the end part of the rod-shaped component can avoid the center of the bottom of the sample container, and the rod-shaped component is prevented from being inserted into the sample bearing component.

Description

Sample processing device, sample analyzer, and sample processing method

Technical Field

The present invention relates to the field of detection technologies, and in particular, to a sample processing device, a sample analyzer, and a sample processing method.

Background

In the detection and analysis process, the rod-shaped member is often inserted into the sample container by an automatic operating mechanism to process the sample liquid in the sample container. However, a sample carrier such as a cotton swab or swab may be placed in the sample container, and is typically wrapped with an absorbent material, such as cotton, at its sampling end. The absorbent material of the sample carrier member is adhered with exudate, excrement or animal or plant tissue fluid before being placed in the sample container. The sample carrier is placed into the sample container with the sampling end against the bottom of the sample container, the space of the sample container narrowing towards the center of its bottom. Because the rod-shaped member may have a small diameter and the sample container itself has an elongated shape, when the rod-shaped member extends into the sample container, the rod-shaped member has a large chance to be inserted into the sampling end of the sample carrier member, when the rod-shaped member leaves the current sample container, the sample carrier member in the current sample container leaves the sample container together with the rod-shaped member, and may enter the next sample container together with the rod-shaped member, thereby causing cross transfer between samples and affecting the accuracy of subsequent detection. Furthermore, if the rod-shaped member is moved with the sample carrier member, the rod-shaped member may get jammed and even break as a result when passing through a narrow space.

Disclosure of Invention

In view of the above, it is desirable to provide a sample processing device, a sample analyzer, and a sample processing method, which are capable of solving a problem that a rod-like member is likely to be inserted into a sampling end of a sample support member when the rod-like member is inserted into a sample container.

A sample processing device, comprising:

a rod-shaped member for protruding into a sample container for accommodating a sample-bearing member to which a sample is adhered and a diluting liquid for diluting the sample;

and a control part for controlling the rod-shaped component to extend into the sample container along the central area of the sample container, then controlling the rod-shaped component to move towards the direction close to the side wall of the sample container, and further controlling the rod-shaped component to move towards the bottom of the sample container.

In the sample processing apparatus, the rod-like member needs to be inserted into the sample container before the diluent in the sample container is processed. Due to the narrowing of the bottom space of the sample container, the sampling end of the sample carrier, such as a cotton swab or a swab, automatically slides down and rests against the center of the bottom of the sample container. The rod-shaped member starts to enter the sample container along the central area and thus is able to stably avoid the edge of the opening of the sample container and reliably enter the relatively narrow opening of the sample container. When the rod-shaped component is positioned in the sample container, the rod-shaped component moves close to the side wall of the sample container, avoids the central area of the sample container, and then moves along the direction close to the bottom of the sample container, so that when the rod-shaped component moves to be close to the bottom of the sample container, the end part of the rod-shaped component can avoid the center of the bottom of the sample container, and the rod-shaped component is prevented from being inserted into the sampling end of the sample bearing component.

In one embodiment, the central region is a central region of the opening of the sample container.

In one embodiment, the control portion controls the rod-like member to protrude into the sample container along a center of the opening of the sample container.

In one embodiment, when the control portion controls the rod-shaped member to be inserted, the longitudinal direction of the rod-shaped member is kept parallel to the center line of the sample container.

In one embodiment, the control portion controls the rod-like member to move in a direction close to the side wall of the sample container after controlling the end portion of the rod-like member to protrude into a middle position of the sample container in the depth direction.

In one embodiment, the control portion controls the rod-shaped member to move in a direction close to the side wall of the sample container after controlling the rod-shaped member to extend into the predetermined distance.

In one embodiment, after the rod-shaped member is controlled to move to the bottom of the sample container, the control portion controls the rod-shaped member to stir the sample-bearing member and the diluent, so that the sample is detached from the sample-bearing member.

In one embodiment, the control portion controls the rod-shaped member to rotate around the sample support member to agitate the sample support member and the diluent, so that the sample is released from the sample support member.

A sample analyzer, comprising: the device comprises a sample adding module, a detection module and a sample processing device; the rod-shaped component is used for stirring the sample bearing component and the diluent in the sample container to enable the sample to fall off from the sample bearing component; the sample adding module is used for extracting a quantitative sample from the sample container to the detection module, and the detection module is used for detecting and analyzing the quantitative sample.

A sample analyzer, comprising: an elution module, a detection module and a sample processing device; the elution module is used for stirring the sample bearing part and the diluent in the sample container to enable the sample to fall off from the sample bearing part; the rod-shaped part is arranged in a hollow way, and the sample processing device extracts quantitative samples from the sample container through the rod-shaped part; the detection module receives the quantitative sample extracted by the rod-shaped component and performs detection analysis on the quantitative sample.

A method of sample processing comprising the steps of:

a probing process in which a rod-like member is extended along a central region of a sample container into the sample container accommodating a sample bearing member to which a sample is adhered and a diluting liquid for diluting the sample;

a side leaning process, wherein the rod-shaped component moves towards the direction close to the side wall of the sample container;

the rod-like member is moved toward the bottom of the sample container in the deep probing process.

Drawings

FIG. 1 is a schematic diagram of a sample analyzer according to an embodiment of the present invention;

FIG. 2 is a side view of a sample processing device according to one embodiment of the invention;

FIG. 3 is a front view of the sample processing device of FIG. 2;

FIG. 4 is a side view of a sample processing device according to another embodiment of the invention;

FIG. 5 is a front view of the sample processing device of FIG. 4;

FIG. 6 is a flowchart of a sample processing method according to an embodiment of the invention.

Reference numerals are as follows:

10. a sample analyzer; 11. an elution module; 12. a sample adding module; 13. a detection module; 20a/20b, a sample processing device; 30a/30b, a rod-shaped member; 40a/40b, a control unit; 41. a translation adjusting module; 411. a translation adjusting bracket; 412. a translation actuator; 42. a first lifting adjusting module; 421. a first lifting adjusting frame; 422. a first lift drive; 43. a stirring driving module; 431. a stirring driver; 432. stirring the transmission piece; 44. a base; 45. a transverse moving adjusting module; 451. a transverse moving frame; 452. a traverse actuator; 46. a longitudinal movement adjusting module; 461. longitudinally moving the frame; 462. a longitudinal movement driver; 47. a second lifting adjusting module; 471. a second lifting adjusting frame; 472. a second elevation drive; 48. a vertical seat; 500. a sample container; 501. an opening; 502a/502b, container holder.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanying figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise explicitly stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly, e.g., as being permanently connected, detachably connected, or integral; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be interconnected within two elements or in a relationship where two elements interact with each other unless otherwise specifically limited. The specific meanings of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "above," and "over" a second feature may be directly on or obliquely above the second feature, or may simply mean that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

The technical scheme provided by the embodiment of the invention is described in the following with reference to the accompanying drawings.

The present invention provides a sample analyzer 10.

The sample analyzer 10 is used to detect samples of body fluids, secretions, excretions, or interstitial fluid. In one embodiment, the sample analyzer 10 is used to detect and analyze gynecological secretions.

In some embodiments, a sample of bodily fluid, interstitial fluid, exudate or waste of the human body is sampled by the sample support member, such that the sample of bodily fluid, interstitial fluid, exudate or waste of the human body adheres to the sampling end of the sample support member. In other embodiments, body fluids, interstitial fluids, secretions or excretions, which may also be of animals or plants, are sampled by the sample support member.

In some embodiments, the sample support member may be a cotton swab, or other absorbent material wrapped member. In particular, an absorbent material is typically present at the sampling end of the sample support member, i.e. at one of the ends of the sample support member, wherein the absorbent material may be cotton or other easily adhesive material.

After the sample carrier is sampled, the sample carrier is placed into the sample container 500 and the sampling end of the sample carrier is soaked with the diluent in the sample container 500. After the sample is separated from the sampling end of the sample bearing part, the diluent can be enabled to carry the components of the sample. In one embodiment, the sample container 500 is a test tube.

In the embodiment shown in fig. 1, the sample analyzer 10 includes an elution module 11, a sample application module 12 connected to the elution module 11, and a detection module 13 connected to the sample application module 12. The elution module 11 is used to accelerate the detachment of the sample from the sample support member and ensure that the diluent has sufficient sample composition. Specifically, the elution module 11 stirs the sample carrier and the diluent in the sample container 500 by the stirring rod, and the diluent accelerates to flow in the sample container 500, so that the efficiency of separating the sample from the sampling end of the sample carrier can be improved. The sample adding module 12 is used for extracting a quantitative sample containing a sample component and a diluent component in the sample container 500 to the detection module 13. Specifically, the sample application module 12 pumps a fixed amount of sample from the sample container 500 to the detection module 13 through the sample application needle. The detection module 13 is used for detecting the quantitative sample taken out by the sample adding module 12. In some embodiments, the detection module 13 performs dry chemistry detection on the quantified sample. In other embodiments, the detection module 13 performs morphological detection on the quantified sample. Alternatively or additionally, the detection module 13 is used to perform dry chemistry detection, morphology detection, and other detection to detect relevant parameters or relevant properties of the confirmed sample.

The invention provides a sample processing device 20a.

In some embodiments, as shown in fig. 2, the sample processing device 20a includes a rod-shaped member 30a and a control portion 40a. The sample container 500 is used for accommodating a sample carrier and a diluent. Specifically, the sample carrier member has a sample adhered thereto, and the diluent is used to dilute the sample. The rod-shaped member 30a is adapted to extend into the sample container 500 to perform a corresponding process on the sample carrier or diluent in the sample container 500. More specifically, the control portion 40a is configured to control the rod member 30a to extend into the sample container 500 along the central region of the sample container 500, then control the rod member 30a to move in a direction to approach the sidewall of the sample container 500, and then control the rod member 30a to move toward the bottom of the sample container 500. Specifically, when the rod member 30a moves in a direction to approach the sidewall of the sample container 500, the rod member 30a moves from a position near the center of the sample container 500 toward the inner surface of the sidewall of the sample container 500. In some embodiments, the sample container 500 is formed of a sidewall and a bottom, more specifically, the sidewall is tubular and the bottom is connected to one end of the sidewall.

Due to the narrowing of the bottom space of the sample container 500, the sampling end of the sample carrier, such as a cotton swab or a swab, automatically slides down and abuts against the center of the bottom of the sample container 500. The rod-shaped member 30a begins to enter the sample container 500 along the central region thereof, thereby stably avoiding the edge of the opening 501 of the sample container 500 and reliably entering the relatively narrow opening 501 of the sample container 500. When the rod-like member 30a is in the sample container 500, the rod-like member 30a moves close to the side wall of the sample container 500 to avoid the central region of the sample container 500, and then moves in the direction close to the bottom of the sample container 500, so that when the rod-like member 30a moves close to the bottom of the sample container 500, the end of the rod-like member 30a can avoid the center of the bottom of the sample container 500, and the rod-like member 30a is prevented from being inserted into the sampling end of the sample-holding member.

In some embodiments, the central region is a central region of the opening 501 of the sample container 500. In one embodiment, the central region is a circular region centered at the center of the opening 501 of the sample container 500, and the diameter of the central region is less than the inner diameter of the opening 501 of the sample container 500. Since the rod-like member 30a passes through the opening 501 of the sample container 500 from the central region, the end of the rod-like member 30a can easily avoid the edge of the opening 501 of the sample container 500, and collision between the end of the rod-like member 30a and the edge of the opening 501 of the sample container 500 can be avoided. In another embodiment, the central region is a region that coincides with the center of the opening 501 of the sample container 500 and has a shape that approximates the shape of the opening 501 of the sample container 500, and the area of the central region is smaller than the area of the opening 501 of the sample container 500.

More specifically, the control portion 40a controls the rod-like member 30a to protrude into the sample container 500 along the center of the opening 501 of the sample container 500. Therefore, when the control part 40a has small deviation of the movement control of the rod-shaped component 30a, the rod-shaped component 30a can still be kept in the central area under the movement deviation, and the precision requirement on the control part 40a is reduced. Understandably, the center of the opening 501 of the sample container 500 is the geometric center of the shape of the opening 501.

In some embodiments, when the controller 40a controls the rod member 30a to be inserted, the longitudinal direction of the rod member 30a is parallel to the center line of the sample container 500. Specifically, the centerline of the sample container 500 is a straight line passing through the geometric center of the opening 501 of the sample container 500 in the depth direction of the sample container 500. Thus, when the rod-like member 30a is moved relative to the sample container 500, the radial distances between different portions of the rod-like member 30a and the sidewall of the sample container 500 are consistent, thereby avoiding the need to continuously adjust the angle of the rod-like member 30a when the rod-like member 30a is inserted into the sample container 500. Specifically, the radial distance is a straight-line distance in a plane perpendicular to the depth direction of the sample container 500, between the rod-like member 30a and the sidewall of the sample container 500.

In some embodiments, after the control part 40a controls the rod-shaped member 30a to extend into the sample container 500 by a preset distance, the control part 40a controls the rod-shaped member 30a to move in a direction approaching the sidewall of the sample container 500. Specifically, the rod-like member 30a stops moving close to the side wall of the sample container 500 after moving to a position spaced apart from the side wall of the sample container 500 by a predetermined gap. By providing the predetermined gap, when the controller 40a controls the rod-like member 30a to move further into the bottom of the sample container 500, friction between the rod-like member 30a and the sidewall of the sample container 500 can be avoided, and the smoothness of movement of the rod-like member 30a and the abrasion of the rod-like member 30a or the sample container 500 can be ensured. Specifically, when the rod-shaped member 30a is moved in a direction to approach the sidewall of the sample container 500, the rod-shaped member 30a may be moved in a direction perpendicular to the depth of the sample container 500.

In other embodiments, the control unit 40a controls the rod member 30a to move in a direction toward the sidewall of the sample container 500 after the end of the rod member 30a extends into the middle of the sample container 500 in the depth direction. Specifically, the middle position of the sample container 500 in the depth direction is a position of the sample container 500 near the midpoint between the open end and the closed end thereof. Similarly, the rod member 30a stops moving close to the sidewall of the sample container 500 when it moves to have a predetermined gap from the sidewall of the sample container 500.

In some embodiments, when the control unit 40a controls the rod-shaped member 30a to move toward the bottom of the sample container 500, the longitudinal direction of the rod-shaped member 30a is parallel to the center line of the sample container 500. Further, before the end of the rod-like member 30a contacts the bottom of the sample container 500, the rod-like member 30a stops moving toward the bottom of the sample container 500, so that interference between the end of the rod-like member 30a and the sample container 500 is avoided, and the rod-like member 30a is prevented from being broken due to the interference.

In some embodiments, the sample processing device 20a functions as the elution module 11 and the rod-shaped member 30a functions as a stirring rod.

Specifically, after the control rod member 30a moves to the bottom of the sample container 500, the control portion 40a controls the rod member 30a to stir the sample-bearing member and the diluent, thereby causing the sample to fall off the sample-bearing member. Further, the control portion 40a controls the rod-like member 30a to rotate around the sample bearing member to stir the sample bearing member and the diluent to cause the sample to fall off the sample bearing member. When the rod-shaped member 30a rotates around the sample bearing member, the diluent around the sampling end of the sample bearing member can rotate around the sampling end, the sampling end of the sample bearing member can be washed by the diluent at different angles, and the separation of the sample from the sample bearing member is accelerated.

In some embodiments, as shown in fig. 2, a plurality of sample containers 500 are arranged side by side on a container holder 502a, and the control portion 40a is disposed at one side of the container holder 502 a. The container holder 502a can move the sample container 500 relative to the control portion 40a along the direction in which the plurality of sample containers 500 are arranged. Specifically, the control unit 40a includes a translation adjusting module 41, a first elevation adjusting module 42, and a stirring driving module 43. The translational adjustment module 41 is used for driving the rod-shaped member 30a to move in a direction perpendicular to the side-by-side straight line where the plurality of sample containers 500 are located. Meanwhile, the depth direction of the sample container 500 is perpendicular to the driving direction of the translational adjustment module 41 for the rod-shaped member 30a, so that the container holder 502a brings the sample container 500 to be stirred to a station below the rod-shaped member 30a before the rod-shaped member 30a extends into the opening 501 of the sample container 500, and the translational adjustment module 41 can be used to adjust the end of the rod-shaped member 30a to be aligned with the central region of the opening 501 of the sample container 500. After the end of the rod-like member 30a is inserted into the sample container 500, the translational adjustment module 41 is configured to drive the rod-like member 30a to move toward the side wall of the sample container 500. The first elevation adjustment module 42 is configured to drive the rod member 30a to move in the depth direction of the sample container 500, so that the rod member 30a can extend into the opening 501 of the sample container 500 and the rod member 30a can move toward the bottom of the sample container 500. The stirring driving module 43 is used to drive the rod-shaped member 30a to rotate around the stirring axis, so as to make the diluent in the sample container 500 flow and make the sample bearing member in the sample container 500 rotate, thereby accelerating the separation of the sample from the sample bearing member.

In the embodiment shown in fig. 2 and 3, the control unit 40a further includes a base 44 provided on the container holder 502a side. The pan adjustment module 41 includes a pan adjustment bracket 411 slidably coupled to the base 44 and a pan driver 412 coupled to the base 44. The translational actuator 412 drives the translational adjustment frame 411 to move relative to the base 44, and the first elevation adjustment module 42 and the stirring driving module 43 are mounted on the translational adjustment frame 411. Specifically, the sliding direction of the translational adjustment rack 411 with respect to the base 44 is arranged perpendicular to the side-by-side direction of the plurality of sample containers 500, and the translational adjustment rack 411 is arranged to extend upward, i.e., away from the base 44. The translational actuator 412 is used to move the translational adjustment bracket 411 away from or toward the container holder 502 a.

In the embodiment shown in fig. 2, the translation actuator 412 is a lead screw motor, and the translation actuator 412 controls the positions of the translation adjusting bracket 411 and the rod-like member 30a in the horizontal direction shown in fig. 2 in cooperation with a nut member attached to the translation adjusting bracket 411. In an embodiment not shown, the translation actuator 412 may also control the movement of the translation adjustment bracket 411 by cooperating with a lead screw or other transmission component.

Specifically, the translation driver 412 controls the moving distance of the translation adjusting rack 411 and the rod-shaped member 30a according to the control signal, determines the relative position between the rod-shaped member 30a and the sample container 500 according to the known center line position of the sample container 500, the inner diameter of the sample container 500, and the translation driver 412 according to the rotation feedback signal, thereby enabling to control the rod-shaped member 30a to enter the sample container 500 from the center region of the opening 501 of the sample container 500 and to accurately move the rod-shaped member 30a to a position spaced apart from the sidewall of the sample container 500 by a predetermined gap.

In some embodiments, the first lift adjustment module 42 includes a first lift adjustment bracket 421 slidably coupled to the translational adjustment bracket 411 and a first lift actuator 422 coupled to the translational adjustment bracket 411. The first elevating driver 422 is used for driving the first elevating adjustment frame 421 to move away from or close to the base 44. Specifically, the sliding connection direction of the first elevating adjustment frame 421 and the translational adjustment frame 411 is parallel to the depth direction of the sample container 500.

In the embodiment shown in fig. 2, the first elevation driver 422 is a lead screw motor, and the first elevation driver 422 controls the positions of the first elevation adjusting frame 421 and the rod member 30a in the vertical direction shown in fig. 2 in cooperation with a nut member mounted on the first elevation adjusting frame 421. In an embodiment not shown in the drawings, the first elevation driver 422 may also control the movement of the first elevation adjusting frame 421 through cooperation with a lead screw or other transmission member.

In some embodiments, the stirring drive module 43 includes a stirring driver 431, and an output shaft of the stirring driver 431 drives the rod-shaped member 30a to rotate around the stirring axis. In one embodiment, the agitator axis coincides with the axial center of the output shaft of the agitator drive 431. In another embodiment, the stirring driver 431 drives the rod-shaped member 30a to rotate through the stirring transmission member 432, and the stirring axis coincides with the rotation axis of the stirring transmission member 432. Specifically, the agitating driver 431 is a motor.

Further, after the rod member 30a is moved to the bottom of the sample container 500, the stirring axis coincides with the center line of the sample container 500 to avoid the rod member 30a from hitting the side wall of the sample container 500 when rotating.

After the rod-shaped member 30a reaches the bottom of the sample container 500 and the stirring of the sample-bearing member and the diluent is completed, the first elevation adjustment module 42 withdraws the stirring rod from the sample container 500. Thereafter, the container holder 502a drives each sample container 500 to move in the direction in which the plurality of sample containers 500 are arranged, so that the next sample container 500 to be stirred reaches a position below the rod member 30a, the translational adjustment module 41 and the first elevation adjustment module 42 control the rod member 30a to enter the sample container 500, and the stirring drive module 43 controls the rod member 30a to stir the sample container 500.

In other embodiments, the control unit 40a may be configured to allow the rod-shaped member 30a to enter the sample container 500 in a predetermined manner.

In other embodiments, the sample processing device 20b serves as the sample application module 12, and the rod-shaped member 30b serves as a sample application needle.

Specifically, as shown in fig. 4 and 5, the control unit 40b includes a traverse adjusting module 45, a longitudinal adjusting module 46, and a second elevation adjusting module 47. The traverse adjustment module 45 is configured to drive the rod member 30b to move in a direction perpendicular to the side-by-side line where the plurality of sample containers 500 are located, and the traverse adjustment module 46 is configured to drive the rod member 30b to move in a direction parallel to the side-by-side line where the plurality of sample containers 500 are located. Meanwhile, the depth direction of the sample container 500 is perpendicular to the driving direction of the traverse adjustment module 45 to the rod member 30 b. The traverse adjustment module 45 and the longitudinal movement adjustment module 46 can thus be used to adjust the end of the rod-like member 30b to be aligned with the central region of the opening 501 of the sample container 500 before the rod-like member 30b is inserted into the opening 501 of the sample container 500. After the end of the rod member 30b is inserted into the sample container 500, the traverse adjustment module 45 or the longitudinal adjustment module 46 is used to drive the rod member 30b to move in a direction close to the side wall of the sample container 500. The second elevation adjustment module 47 is configured to drive the rod member 30b to move in the depth direction of the sample container 500, so that the rod member 30b can extend into the opening 501 of the sample container 500 and the rod member 30b can move toward the bottom of the sample container 500.

Specifically, the sample processing device 20b further includes a stand 48 disposed on one side of the container holder 502 b.

In the embodiment shown in fig. 4, the traverse-motion adjusting module 45 includes a traverse frame 451 slidably connected to the vertical base 48 and a traverse actuator 452 connected to the vertical base 48, and the traverse frame 451 is moved by the traverse actuator 452 in a direction perpendicular to the alignment of the plurality of sample containers 500. Specifically, the traverse actuator 452 is a motor, and the traverse actuator 452 drives the traverse frame 451 to move relative to the vertical base 48 via a belt. In some embodiments, not shown, the traverse actuator 452 may also employ a lead screw motor to move the traverse frame 451 by cooperating with a nut.

In the embodiment shown in fig. 5, the longitudinal movement adjusting module 46 includes a longitudinal movement frame 461 slidably connected to the transverse movement frame 451 and a longitudinal movement driver 462 connected to the transverse movement frame 451, and the longitudinal movement driver 462 drives the longitudinal movement frame 461 to move along a parallel direction of the plurality of sample containers 500. Specifically, the longitudinal driver 462 is a lead screw motor, and the longitudinal driver 462 drives the longitudinal frame 461 to move by matching with a nut. More specifically, the direction in which the longitudinal movement frame 461 moves away from or approaches the lateral movement frame 451 is parallel to the side-by-side direction of the plurality of sample containers 500.

In the embodiment shown in fig. 6, the second lifting/lowering adjusting module 47 includes a second lifting/lowering adjusting frame 471 slidably connected to the longitudinal moving frame 461 and a second lifting/lowering driver 472 connected to the longitudinal moving frame 461. The second lifting driver 472 is used for driving the second lifting adjusting frame 471 to move away from or close to the stand 48. Specifically, the sliding connection direction of the second ascent and descent adjusting frame 471 and the vertically moving frame 461 is parallel to the depth direction of the sample container 500. The rod member 30b is mounted on the lower side of the second ascent and descent adjusting frame 471.

Further, in order to serve as the sample application module 12, the sample processing device 20b may further include necessary auxiliary components, such as a pump body for generating low pressure to suck a fixed amount of sample into the hollow rod-shaped member 30b, as needed.

In the embodiment shown in fig. 5, before the rod-shaped member 30b enters the opening 501 of the sample container 500, the traverse actuator 452 moves the traverse rack 451 in a direction perpendicular to the side-by-side alignment of the plurality of sample containers 500, and at the same time, the longitudinal actuator 462 moves the longitudinal rack 461 in a direction parallel to the side-by-side alignment of the plurality of sample containers 500, so that the end of the rod-shaped member 30b can be aligned with the central area of the opening 501 of the sample container 500 or the rod-shaped member 30b can be aligned with the center of the opening 501 of the sample container 500. Thereafter, the second elevation driver 472 drives the second elevation adjustment frame 471 and the rod member 30b to move in the depth direction of the sample container 500, so that the end of the rod member 30b enters the opening 501 of the sample container 500.

After the end of the rod-shaped member 30b is inserted into the middle position of the sample container 500 in the depth direction, or after the rod-shaped member 30b is inserted into the sample container 500 by a predetermined distance, in one embodiment, the traverse actuator 452 moves the traverse frame 451 in a direction perpendicular to the side-by-side straight line of the plurality of sample containers 500, so that the rod-shaped member 30b is close to the sidewall of the sample container 500. In another embodiment, the longitudinal driver 462 can drive the longitudinal frame 461 to move along a direction parallel to the plurality of sample containers 500 side by side, so that the rod-shaped member 30b is close to the sidewall of the sample container 500. In one embodiment, the traversing driver 452 and the longitudinally moving driver 462 may simultaneously drive the rod-shaped member 30b to move, so that the rod-shaped member 30b is close to the sidewall of the sample container 500.

In some embodiments, the second lifting driver 472 drives the second lifting/lowering adjusting frame 471 and the rod member 30b to move further, so that the end of the rod member 30b moves to be close to the bottom of the sample container 500. In conjunction with other necessary members, a low pressure is formed in the rod-like member 30b, and the diluent in the sample container 500 is sucked into the hollow rod-like member 30b to obtain a quantitative sample. Thereafter, the rod member 30b is moved away from the sample container 500 by the traverse adjustment module 45, the vertical adjustment module 46, and the second elevation adjustment module 47. Then, under the driving of the traverse adjusting module 45, the traverse adjusting module 46 and the second elevation adjusting module 47, the rod-shaped member 30b moves to a position close to the detecting module 13, and releases the temporarily stored quantitative sample to the detecting module 13.

In other embodiments, when one end of the hollow rod-shaped member 30b is immersed in the diluent, the other end of the hollow rod-shaped member 30b is connected to a tube, and with the aid of a peristaltic pump or other necessary members, the quantitative sample passes through the rod-shaped member 30b and the tube in sequence, is then transferred to the detection module 13, and is detected by the detection module 13.

The present invention provides a sample processing method S600, as shown in fig. 6, comprising the steps of:

a probing process S601 in which the rod-like member 30a is extended along a central region of the sample container 500 into the sample container 500 accommodating the sample bearing member to which the sample is adhered and a diluent for diluting the sample;

in the side approach process S602, the rod-like member 30a moves in a direction approaching the sidewall of the sample container 500;

in the deep probing process S603, the rod-like member 30a moves toward the bottom of the sample container 500.

Specifically, in the probing process S601, the center region is the center region of the opening 501 of the sample container 500, and a space is provided between the center region and the edge of the opening 501 of the sample container 500 to avoid collision between the end of the rod-like member 30a and the edge of the opening 501 of the sample container 500 and to avoid the rod-like member 30a from falling out of the opening 501 of the sample container 500 due to deviation when moving down. More specifically, the rod-like member 30a protrudes into the sample container 500 along the geometric center of the opening 501 of the sample container 500. When the rod-like member 30a passes through the central region, the longitudinal direction of the rod-like member 30a is arranged in parallel with the depth direction of the sample container 500 to simplify the control of the rod-like member 30a in the depth direction of the sample container 500.

With respect to the side rest process S602, in some embodiments, after the rod member 30a is extended into the sample container 500 by a predetermined distance, the rod member 30a is moved in a direction to approach the sidewall of the sample container 500. In particular, the preset distance may be adjusted according to the depth of the sample container 500 to avoid in advance the extent of the plane that may come into contact with the sampling end of the sample carrier. The rod-like member 30a stops moving close to the sidewall of the sample container 500 when it moves to have a predetermined gap with the sidewall of the sample container 500. Or stops moving close to the sidewall of the sample container 500 after the rod-like member 30a leaves the central region, which is spaced apart from the opening edge of the sample container 500 by more than the diameter of the rod-like member 30 a. More specifically, when the rod-like member 30a is moved in a direction approaching the side wall of the sample container 500, the longitudinal direction of the rod-like member 30a is kept parallel to the depth direction of the sample container 500.

In the side rest process S602, in some other embodiments, after the end of the rod member 30a is inserted into the middle position of the sample container 500 in the depth direction, the rod member 30a is moved in a direction to come close to the side wall of the sample container 500. Specifically, the middle position of the sample container 500 in the depth direction is a position of the sample container 500 near the midpoint between the open end and the closed end thereof. The rod-like member 30a stops moving close to the side wall of the sample container 500 when it moves to have a predetermined gap with the side wall of the sample container 500.

For the deep probing process S603, in some embodiments, after the rod member 30a is moved to have a predetermined gap with the sidewall of the sample container 500, the rod member 30a is moved toward the bottom of the sample container 500. The rod-like member 30a stops moving toward the bottom of the sample container 500 before the end of the rod-like member 30a contacts the bottom of the sample container 500.

For the deep probing process S603, in other embodiments, the rod-shaped members 30a are moved toward the bottom of the sample container 500 after the rod-shaped members 30a are moved away from the central region.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. A sample processing device, comprising:

a rod-shaped member for protruding into a sample container for accommodating a sample-bearing member to which a sample is adhered and a diluting liquid for diluting the sample;

and the control part is used for controlling the rod-shaped part to extend into the sample container along the central area of the sample container, then controlling the rod-shaped part to move towards the direction close to the side wall of the sample container, and then controlling the rod-shaped part to move towards the bottom of the sample container.

2. The sample processing device of claim 1, wherein the central region is a central region of an opening of the sample container.

3. The sample processing device according to claim 1, wherein the control portion controls the rod-like member to protrude into the sample container along a center of an opening of the sample container.

4. The sample processing device according to claim 2, wherein when the controller controls the rod-like member to be inserted, a longitudinal direction of the rod-like member is kept parallel to a center line of the sample container.

5. The sample processing device according to claim 1, wherein the control portion controls the rod-like member to move in a direction to approach the side wall of the sample container after controlling the end portion of the rod-like member to protrude to a position midway in the depth direction of the sample container.

6. The sample processing device according to claim 1, wherein the control portion controls the rod-like member to move in a direction close to the side wall of the sample container after controlling the rod-like member to extend into the predetermined distance.

7. The sample processing device according to claim 1, wherein the control section controls the rod-like member to stir the sample-supporting member and the diluent to detach the sample from the sample-supporting member after controlling the rod-like member to move to the bottom of the sample container.

8. The sample processing device according to claim 7, wherein the control portion controls the rod-like member to rotate around the sample bearing member to agitate the sample bearing member and the diluent to cause the sample to fall off the sample bearing member.

9. A sample analyzer, comprising: a sample application module, a detection module and a sample processing device according to any one of claims 1 to 6; the rod-shaped component is used for stirring the sample bearing component and the diluent in the sample container to enable the sample to fall off from the sample bearing component; the sample adding module is used for extracting a quantitative sample from the sample container to the detection module, and the detection module is used for detecting and analyzing the quantitative sample.

10. A method of sample processing, comprising the steps of:

a probing process in which a rod-like member is extended along a central region of a sample container into the sample container accommodating a sample bearing member to which a sample is adhered and a diluting liquid for diluting the sample;

a side leaning process, wherein the rod-shaped component moves towards the direction close to the side wall of the sample container;

the rod-like member is moved toward the bottom of the sample container in the deep probing process.

Images