CN1155382A - Wide spectrum disinfective agent - Google Patents

Abstract

A broad-spectrum germicidal disinfectant includes such active components as fluoroquinolone antimicrobials (norfloxacin, for example), nitroimidazole antimicrobials (such as metronidazole) and hibitane, and features high germicidal power, broad spectrum and quick action.

Description

Wide spectrum disinfective agent

The invention belongs to compound preparation, be specifically related to a kind of wide spectrum disinfective agent.

In the daily life, people's skin surface usually can built up a large amount of bacteriums, and as Escherichia coli, hay bacillus, staphylococcus aureus etc., these bacteriums are accumulated to and to a certain degree will health be threatened; The chance that the women infects various gynecological diseases is also very big, and various bacillary, gonococcus property, mycotic, trichomonad property and senile vahinitis are often troubling the adult women more than 90%; Daily life tools and clothing are also often carrying different harmful germs, all can threaten to health, so people extremely need effective disinfection sanitizer, and Chinese medicine class disinfection sanitizer in the market, storage life is short, instability, curative effect is not obvious; And the Western medicine single preparations of ephedrine is defended ＂ etc. as ＂ Swashes ＂, ＂ black pigment used by women in ancient times to paint their eyebrows, and its antimicrobial spectrum is narrow, can not effectively kill the multiple germ that may exist simultaneously, has limited the scope of application.

The present invention is directed to the deficiency of existing disinfection sanitizer, a kind of wide spectrum disinfective agent that can kill multiple harmful germ simultaneously is provided.

The present invention selects the fluoroquinolone antibacterial agent that Gram-negative bacteria is had very strong antibacterial ability for use, trichomonad and amoeba worm are had the nitro glyoxaline antimicrobial of the strongest killing action and Gram-positive and negative bacterium (comprising Pseudomonas aeruginosa) are all had the hibitane of strong killing action as effective ingredient, through repetition test, determine that optimum ratio compound forms, its sterilizing ability is strengthened greatly than the sterilizing ability of its folk prescription, the more important thing is and to kill multiple harmful germ effectively simultaneously, reach the purpose of treatment and health care.The compositing range of its effective ingredient (percetage by weight) is:

Fluoroquinolone antibacterial agent 13.5--22,

Nitro glyoxaline antimicrobial 26.5--42,

Hibitane 39.5--55,

The effective ingredient that the present invention recommends to select for use is a Norfloxacin, metronidazole and hibitane, and its compositing range (percetage by weight) is:

Norfloxacin 15--20,

Metronidazole 30--40,

Hibitane 42--52.

Effective ingredient of the present invention is preferably selected following compositing range (percetage by weight) for use:

Norfloxacin 17.5--18.5,

Metronidazole 34.5--38.5,

Hibitane 43.5--47.5.

When reality is prepared, also need an amount of additive, as polyethylene glycol, glycerine, ethylene glycol etc. add the sterile water dilution at last.The general content range (percetage by weight) of effective ingredient in wide spectrum disinfective agent of the present invention is 0.08--0.2, and additives polyethylene glycol is 0.01--0.02, and glycerine is 0.008--0.015, and ethanol is 0.07--0.1.

Compare with existing disinfection sanitizer, wide spectrum disinfective agent of the present invention, overcome the shortcoming of existing Chinese medicine and Western medicine single preparations of ephedrine effectively, its sterilizing ability is strengthened greatly than the sterilizing ability of its folk prescription, the more important thing is and to kill multiple harmful germ effectively simultaneously, reach the purpose of treatment and health care.Advantages such as have has a broad antifungal spectrum, sterilizing power is strong, and sterilization is rapid, and bactericidal effect is good.

Embodiment:

Take by weighing Norfloxacin 2 grams, place beaker, add 100 ml sterile waters, be heated to 90 ℃, constantly stir, use the glacial acetic acid titration, until obtaining settled solution;

Take by weighing metronidazole 4 grams, place beaker, add 100 ml sterile waters, heating is also constantly stirred, until obtaining settled solution;

Take by weighing hibitane 5 grams, place beaker, add 100 milliliters of ethanol, heating for dissolving is until obtaining settled solution;

With above-mentioned three kinds of solution that prepare, add 1.5 milliliters of polyethylene glycol and 1 milliliter of glycerine again, fully mix and stir, add sterile water to 10 liter.

Quantitative sterilizing test: (experimental condition: 20--25 ℃).

Bacterium liquid is diluted to 10 ⁶--10 ⁷Cfu/ml inhales 0.5ml bacterium liquid and is added in the 4.5ml experimental concentration thimerosal, and mixing acted on to the scheduled time, draw 0.5ml bacterium medicine mixed liquor, be added in the neutralizer mixing, neutralize after ten minutes, carry out count plate, replace disinfectant to compare with sterile purified water simultaneously.

Result of the test:

Quantitatively disinfection test result table (repeating 5 times) test strain diluting effect time contrast recovery bacterium number is tested residual bacterium and is counted killing rate

(branch) (average cfu/m1) (average cfu/m1) be Escherichia coli 82 9.6 * 10 (%) ⁶0 100

16 3 9.6 * 10 ⁶1,350 99.98 bacillus subtilis black variety bud cell stostes 5 5.5 * 10 ⁶0 100

2 10 5.5×10 ⁶ 2300 99.96

The submitted sample testing result shows, dilutes 16 times, acts on 2 minutes to colibacillary killing rate and reaches 99.98%; Dilute 5 minutes killing rates to bacillus subtilis black variety bud cell of 2 times of effects and reach 99.96%, disinfection effect is good.

Claims (3)

1. a wide spectrum disinfective agent that includes effective ingredient, additive is characterized in that in wide spectrum disinfective agent,

The content range of effective ingredient (percetage by weight) is 0.08--0.2;

Content of additive scope (percetage by weight) is:

Polyethylene glycol 0.01--0.02,

Glycerine 0.008--0.015,

Ethanol 0.07--0.1;

The sterile water surplus; Described effective ingredient, its compositing range (percetage by weight) is:

Fluoroquinolone antibacterial agent 13.5--22,

Nitro glyoxaline antimicrobial 26.5--42,

Hibitane 39.5--55.

2. wide spectrum disinfective agent as claimed in claim 1 is characterized in that the compositing range (percetage by weight) of described effective ingredient is:

Norfloxacin 15--20,

Metronidazole 30--40,

Hibitane 42--52.

3. wide spectrum disinfective agent as claimed in claim 1 is characterized in that the compositing range (percetage by weight) of described effective ingredient is:

Norfloxacin 17.5--18.5,

Metronidazole 34.5--38.5,

Hibitane 43.5--47.5.