CN115969826A - Skin disinfectant and method for disinfecting skin - Google Patents
Skin disinfectant and method for disinfecting skin Download PDFInfo
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Abstract
The invention discloses the technical field of antibacterial compositions, and particularly relates to a skin disinfectant and a method for disinfecting skin, wherein the skin disinfectant comprises the following components: a) Compound quaternary ammonium salt: 0.72 to 0.88 percent; b) Glycerol: 0.01 to 0.05 percent; c) At least one C2-C3 aliphatic alcohol: 0.9 to 1.1 percent; d) Distilled or deionized water: and (4) the balance. The technical scheme adopts a compound quaternary ammonium salt which mainly comprises didecyl dimethyl ammonium chloride and benzalkonium chloride as a sterilization disinfectant, glycerol as a wetting agent, ethanol as a solvent, the sterilization disinfectant and distilled water as the solvent, the skin disinfectant can inactivate various active substances related to bacteria cells and metabolism, and interfere the synthesis of protein and nucleic acid to influence the energy metabolism of the cells, so that the bacteria die finally, and the compound quaternary ammonium salt has complete killing effects on various microorganisms, viruses and bacteria, such as escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and novel coronavirus, and is a broad-spectrum sterilization compound disinfection formula.
Description
Technical Field
The invention belongs to the technical field of antibacterial compositions, and particularly relates to a skin disinfectant and a method for disinfecting skin.
Background
The existing skin disinfectants are various and comprise chemical disinfectants and traditional Chinese medicine disinfectants, the known chemical disinfectants comprise potassium permanganate, boric acid, hydrogen peroxide, iodophor, alcohol and the like, but the disinfectants are large in irritation and easy to damage the skin.
Although the traditional Chinese medicine disinfectant has mild action and small side effect, the curative effect is not exact.
However, the prevalence rate of antibiotic-resistant microorganisms is increased at present, and particularly, the incidence rate of infection of escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa is obviously increased when seasons are changed, including the incidence rate of infection of novel coronaviruses is also obviously increased.
The main causes of infection with Staphylococcus aureus (Staphylococcus aureus) include nosocomial bloodstream infections, surgical site infections, and pneumonia. Candida albicans is a common fungus, and is generally found in the oral cavity, vagina, intestinal tract and respiratory tract of normal people. When the body has lowered immunity or unbalanced flora, candida albicans can multiply excessively, thereby causing various diseases. Mainly through modes such as public appliances. Pseudomonas aeruginosa (p.aeruginosa) is one of the main pathogenic bacteria of nosocomial infections, as a opportunistic pathogen; infection with pseudomonas aeruginosa generally occurs in immunocompromised persons and is widespread. The novel coronavirus is a beta coronavirus, is enveloped, has particles which are generally round or oval, has stronger infectivity, is generally transmitted through a plurality of transmission paths such as droplet transmission, contact transmission, air aerosol transmission, excrement, urine and the like, and is mainly transmitted through the droplet transmission and the contact transmission.
Products for killing escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and novel coronavirus and blocking infection chains in the existing market generally only can be used for a single infection strain, and the inactivation effect on other infection strains is relatively poor.
Disclosure of Invention
The invention provides a skin disinfectant and a method for disinfecting skin, the technical scheme is that a compound quaternary ammonium salt is adopted, the compound quaternary ammonium salt mainly comprises didecyl dimethyl ammonium chloride and benzalkonium chloride as a disinfectant, glycerol as a wetting agent, ethanol as a solvent and the disinfectant, and distilled water as the solvent to compound the disinfectant, the skin disinfectant can inactivate various active substances related to metabolism in bacterial cells, interfere the synthesis of protein and nucleic acid to influence the energy metabolism of the cells and cause the final death of bacteria, and has complete killing effect on various microorganisms, viruses and bacteria.
The invention is realized by the following technical scheme:
the skin disinfectant comprises the following components in percentage by weight:
a) Compound quaternary ammonium salt: 0.72% -0.88%;
b) Glycerol: 0.01 to 0.05 percent;
c) At least one C2-C3 aliphatic alcohol: 0.9 to 1.1 percent;
d) Distilled or deionized water: and (4) the balance.
Optionally, the compound quaternary ammonium salt consists of didecyl dimethyl ammonium chloride and benzalkonium chloride, and the weight percentages of the two components are as follows:
didecyl dimethyl ammonium chloride: 0.5 to 0.7 percent; benzalkonium chloride: 0.18 to 0.3 percent.
Optionally, the compound quaternary ammonium salt consists of didecyl dimethyl ammonium chloride and benzalkonium chloride, and the weight percentages of the two components are as follows:
didecyl dimethyl ammonium chloride: 0.52 percent; b) Benzalkonium chloride: 0.2 percent.
Optionally, the at least one C2-C3 aliphatic alcohol is ethanol, n-propanol, or isopropanol, or a mixture of any of the foregoing.
Optionally, the at least one C2-C3 aliphatic alcohol is ethanol.
Optionally, the ethanol is 75% ethanol.
Optionally, the skin disinfectant consists of, in weight percent, didecyl dimethyl ammonium chloride: 0.70%, benzalkonium chloride: 0.18%, glycerin: 0.05%, ethanol: 1.1 percent and the balance of distilled water.
Optionally, the distilled or deionized water is 98.0% to 98.3% by weight.
In the technical scheme, the didecyl dimethyl ammonium chloride, namely the decamethyl ammonium chloride and the didecyl dimethyl ammonium chloride is a surfactant ionic agent, belongs to a double-chain quaternary ammonium salt compound, is a light yellow transparent liquid at normal temperature, is easy to dissolve in water and organic solvents, and has stable chemical properties and small irritation. CAS number: 7173-51-5, formula: C22H48CLN, molecular weight: 362.08, and is used as a sterilizing disinfectant in the skin disinfectant.
Benzalkonium chloride belongs to quaternary ammonium cationic surfactant, is white waxy solid or yellow colloid, has neutral or weak alkaline water solution, and can be used for industrial and medical disinfection. Benzalkonium chloride CAS no: 63449-41-2, molecular formula: C21H39CLN, molecular weight: 339.96, as a disinfectant in the skin disinfectant of the technical proposal.
Glycerol, also known as glycerol, is a viscous liquid in body color, odorless, and capable of absorbing moisture. Glycerol CAS number: 56-81-5, as a moisturizer in the skin disinfectants described in the present methods of technology.
The at least one C2-C3 aliphatic alcohol is ethanol, n-propanol or isopropanol or any mixture of the above, specifically any one or a mixture of at least two of ethanol, isopropanol and n-propanol, and ethanol is used as a solvent and a disinfectant in the skin disinfectant.
Meanwhile, deionized water or distilled water in the technical scheme is used as a solvent in the skin disinfectant.
The skin disinfectant compounded by the didecyl dimethyl ammonium chloride, the benzalkonium chloride, the glycerol, the ethanol, the deionized water or the distilled water according to the set proportion can treat bacteria, microorganisms and viruses adsorbed on skin, fabric, public appliances and the like when being sprayed on the skin, the fabric, the public appliances and the like, change the permeability and the permeability of bacterial cells, destroy cell walls and cell membranes of the bacteria, and enable water to enter the bacteria to cause the swelling and the rupture of the bacteria. Proteins and nucleic acids leak out due to the destruction of the cell wall.
The didecyl dimethyl ammonium chloride and the benzalkonium chloride are surfactants, and after the didecyl dimethyl ammonium chloride and the benzalkonium chloride are mixed with glycerol, ethanol, deionized water or distilled water according to a proportion, the whole disinfectant molecule has a good surface activity effect, has specific charges, can be highly gathered on the surfaces of bacteria, and influences the metabolism of bacteria.
The skin disinfectant can inactivate various active substances related to metabolism in bacterial cells, such as enzyme systems of dehydrogenase, oxidase and the like, and interfere the synthesis of protein and nucleic acid to further influence the energy metabolism of the cells, so that the processes of biological oxidation, respiratory metabolism, energy generation and the like are hindered, and the bacteria finally die.
During the use process of the skin disinfectant, the damage degree of virus proteins is increased along with the increase of the dosage of the medicine and the prolonging of the action time, the internal DNA or RNA chain structure is broken, and the chain structure is more seriously damaged when the action concentration is higher.
It is another technical object of the present solution to provide a method of disinfecting skin by applying to a patient a skin disinfectant consisting of a complex quaternary ammonium salt, glycerin, at least one C2-C3 aliphatic alcohol, and distilled or deionized water.
Optionally, the skin disinfectant results in at least a 2 log reduction of bacteria including escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, new coronaviruses after 3 minutes contact with the skin or surrounding substance surface.
Specifically, after being sprayed on skin, fabric and public appliances through a large number of tests in the using process, the disinfectant has the killing rate of over 99.9 percent on staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and other bacteria within 0.5 to 2 minutes, and has the killing rate of over 99.9 percent on hepatitis B surface antigen, namely viruses such as hepatitis B virus outer protein and the like within 5 to 10 minutes.
When the skin disinfectant prepared by the technical scheme is applied to disinfection of skin, fabrics, public appliances and the like, the skin disinfectant can completely kill various microorganisms, viruses and bacteria such as escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and novel coronavirus, has low effective concentration and quick action, and is a compound disinfection formula with broad-spectrum sterilization.
In order to achieve the above technical effects, the skin disinfectant may be applied once or more times when it is specifically used. Meanwhile, the disinfectant in the present technical scheme mainly means inhibiting the growth of organisms including bacteria, viruses, protozoa, prions, yeasts, fungi or other infectious agents, and these agents have an improved substantiation function when mixed with the above agents, which means that it is capable of permeating the skin and of continuing to maintain antibacterial activity after rinsing.
Compared with the prior art, the invention has the following advantages and beneficial effects:
1) The product prepared by the technical scheme is colorless, nonvolatile, free of heavy metal, stable to high temperature and ultraviolet rays, good in water solubility, degradable, mild, non-irritant and free of damage after being used for treating contacted skin, public tools and the like.
2) The skin disinfectant has no toxicity or irritation to skin, and can be used for treating operation wounds, so that the skin disinfectant has wide application range and great popularization value, and is applied to disinfection treatment in industries such as express transportation, high-speed rail airports and the like, disinfection of hospitals and medical products, disinfection and arrangement of public appliances and the like.
3) When the skin disinfectant is used for disinfecting fabrics, the skin disinfectant can be chemically combined with the fabrics, so that active ingredients of the skin disinfectant are firmly attached to the surfaces of fabric fibers and can be cleaned for multiple times, the service cycle of the disinfectant is prolonged, and the skin disinfectant passes national standards such as textile safety technical specifications.
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Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.
Example 1:
a skin disinfectant comprises the following components in percentage by weight:
didecyl dimethyl ammonium chloride: 0.52%, benzalkonium chloride: 0.2%, glycerin: 0.01%, ethanol: 0.9 percent, and the balance being distilled water.
Example 2:
the skin disinfectant comprises the following components in percentage by weight:
didecyl dimethyl ammonium chloride: 0.58%, benzalkonium chloride: 0.3%, glycerin: 0.05%, ethanol: 1.1 percent and the balance of deionized water.
Example 3:
a skin disinfectant comprises the following components in percentage by weight:
didecyl dimethyl ammonium chloride: 0.60%, benzalkonium chloride: 0.25%, glycerin: 0.03%, 75% ethanol: 1.0 percent and the balance of distilled water.
Example 4:
the skin disinfectant comprises the following components in percentage by weight:
didecyl dimethyl ammonium chloride: 0.58%, benzalkonium chloride: 0.3%, glycerin: 0.05%, isopropyl alcohol: 1.0 percent and the balance of deionized water.
The skin disinfectant of the above examples 1 to 4 is prepared by the following method:
adding quantitative amounts of didecyl dimethyl ammonium chloride, benzalkonium chloride and distilled water into a quantitative container, stirring until the mixture is completely dissolved and is in a liquid state, adding quantitative amounts of ethanol or isopropanol, then adding quantitative amounts of glycerol, stirring uniformly until the liquids are completely fused, supplementing distilled water or deionized water to a set total amount, stirring, standing, filtering and packaging.
The product performance and effectiveness of the skin disinfectants described in examples 1-4 were verified as follows:
according to a microbial detection method of a product in appendix B of GB15979-2002 of hygienic Standard for Disposable products, microbial contamination detection is performed on the products 1-4 of the examples under the conditions of a temperature of 20 ℃ and a relative humidity of 55%, and the detection results are as follows in the following table 1:
| detecting items | Unit | The result of the detection | Standard value of | Conclusion |
| Bacterial colony TotalNumber of | cfu/g | 0 | ≤200 | Qualified |
| Total number of fungal colonies | cfu/g | 0 | ≤100 | Qualified |
| Coliform group bacteria | cfu/g | — | — | Qualified |
| Pseudomonas aeruginosa | cfu/g | — | — | Qualified |
| Staphylococcus aureus | cfu/g | — | — | Qualified |
| Candida albicans | cfu/g | — | — | Qualified |
| Hemolytic streptococcus | cfu/g | — | — | Qualified |
(Note: "-" indicates no detection)
As can be seen from the above table, the total bacterial colony number, the total fungal colony number, the coliform group, the Pseudomonas aeruginosa, the Staphylococcus aureus, the Candida albicans and the hemolytic streptococcus of the disinfectant all meet the regulations of GB 15979-2002.
And (II) carrying out a filter washing method identification test on the product of the embodiment by taking escherichia coli as test bacteria according to appendix C of GB15979-2002 of sanitary products for disposable use and technical Specification for disinfection (2002 edition) (Sod-Farad. [2002] ]282) 2.1.11.3.
The experiments were divided into 4 groups, group 1: test sample + bacterial suspension; group 2: treating a test sample by a bacterial suspension and a filtration washing method; group 3: treating the bacterial suspension, water and a filtering and washing method; group 4: bacterial suspension; the action time is 1 minute; the test samples are divided into two types, namely the skin disinfectant stock solution and the 50% diluent of the product in the embodiment 1; the test results are shown in the following tables 2 and 3, respectively:
table 2 above is the skin disinfectant stock solution described in example 1.
Table 3 above is a 50% dilution of the skin antiseptic described in example 1.
The results show that the effect of the disinfectant of the invention on Escherichia coli can be effectively removed by a filtration rinsing method, and the method has no adverse effect on test bacteria.
(III) according to the hygienic standard GB15979-2002 appendix C of the disposable hygienic product and the sterilization technical specification (2002 edition) (defense Law Fair [2002 ]) 2.1.11.3, the product of the embodiment is subjected to sterilization and bacteriostasis tests by taking staphylococcus aureus, escherichia coli, candida albicans and pseudomonas aeruginosa as test bacteria under the test conditions of 20-21 ℃, the skin disinfectant shown in the embodiment 1 is taken as a stock solution, and after the action time of 1 minute, 2 minutes, 5 minutes and 10 minutes, the sterilization rate and the sterilization range of the disinfectant are shown in the following table 4:
the results show that under the test condition, the test sample acts for 1min, and the killing rate to staphylococcus aureus, candida albicans, escherichia coli and pseudomonas aeruginosa is 100 percent, namely the skin disinfectant has extremely strong sterilization and bacteriostasis effects.
(IV) according to appendix C of GB15979-2002 of sanitary products for disposable use and disinfection technical Specification (2002 edition) (Fad of defense supervision No. [2002] 282) 2.1.11.3, the product of the embodiment is subjected to sterilization and bacteriostasis tests by taking staphylococcus aureus, escherichia coli, candida albicans and pseudomonas aeruginosa as test bacteria under the test conditions of 20-21 ℃, the skin disinfectant described in the embodiment 1 is taken as a test product, and the comparison product is prepared: the hypochlorous acid disinfectant, 75% ethanol and 1 99 diluted bleaching water are sprayed for 2 minutes, and then the killing rate and the killing range are detected, and the test results are shown in the following table 5:
wherein, the hypochlorous acid disinfectant is a hypochlorous acid low-temperature disinfectant with 314mg/L of effective chlorine and a hypochlorous acid normal-temperature disinfectant with 122mg/L of effective chlorine respectively.
The above results show that, under the test conditions, the skin disinfectant described in example 1, as a test sample, has a killing rate of 100% for staphylococcus aureus, candida albicans, escherichia coli and pseudomonas aeruginosa after 2min disinfection, i.e., the skin disinfectant of the present invention has very strong bactericidal and bacteriostatic effects. Compared with a comparative disinfectant of hypochlorous acid disinfectant, 75% ethanol and 1.
After the skin disinfectant disclosed in the embodiments 1 to 4 is applied to spraying of staphylococcus aureus, candida albicans, escherichia coli and pseudomonas aeruginosa, the killing rate and the killing range after 1min, 2min, 5min and 10min are similar through tests, which shows that the skin disinfectant disclosed in the embodiments 1 to 4 has the advantages of remarkable killing effect, high action speed and lasting effect, and is a spectrum disinfectant.
And through experimental tests, the skin disinfectant disclosed in the embodiments 1 to 4 can be applied to the express transportation industry, medical products and medical products in hospitals and the outer surface of clothes, and can reduce the survival rate of infectious factors such as bacteria, viruses and microorganisms to the greatest extent, so that the infection possibility of the infectious factors such as the viruses and the bacteria is remarkably reduced.
Example 5:
a method of disinfecting skin comprising applying to a patient a skin disinfectant comprising a quaternary ammonium complex salt, glycerin, at least one C2-C3 aliphatic alcohol, and distilled or deionized water.
Wherein said skin disinfectant results in at least a 2 log reduction of bacteria including Escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, and a novel coronavirus, after 3 minutes contact with the skin or surrounding substance surface.
The skin disinfectants prepared in the embodiments 1 to 4 have the set concentration range, and the killing rate of bacteria such as staphylococcus aureus, escherichia coli, candida albicans and the like can reach more than 99.9%; within 5-10 minutes, the killing rate of viruses such as hepatitis B surface antigen (hepatitis B virus outer protein) and the like can reach more than 99.9 percent.
Meanwhile, the skin disinfectants prepared in examples 1 to 4 can also be applied to disinfection of novel coronaviruses, and the skin disinfectants described in example 1 are tested in disinfection detection as follows:
a test for inactivation of the novel coronavirus SARS-CoV-2 was carried out with reference to section II-2.1.1.7 of Disinfection Specification (2002 edition).
The skin disinfection composition of the embodiment 1 of the invention is subjected to the inactivation detection of SARS-CoV-2, the skin disinfection composition is sprayed to form a coating, the coating is subjected to the action with the new coronavirus SARS-CoV-2 for 2 minutes, 5 minutes, 10 minutes, 1d, 7d and 14d for detection, and blank control is set in the experiment; the results are shown in table 6:
as can be seen from the data in Table 6, the skin disinfectants disclosed by the invention have inactivation effects on the new coronavirus SARS-CoV-2 after 2 minutes, 5 minutes, 10 minutes, 1d, 7d and 14d after treatment, and the inactivation efficiency is more than 99% and even reaches 100% inactivation rate.
Therefore, the instant disinfection effect of the skin disinfectant disclosed by the invention on SARS-CoV-2 is more than 99.9 percent, the disinfection effect on SARS-CoV-2 after 7 days is more than 99.9 percent, and the disinfection effect on SARS-CoV-2 after 14 days is more than 99 percent, thus the skin disinfectant prepared in the embodiment 1 has long-term lasting effect on disinfecting new coronavirus SARS-CoV-2.
In conclusion, the skin disinfectant disclosed by the technical scheme is suitable for sterilization and disinfection in various places, and has the characteristics of long-term lasting effect and capability of being sprayed, wiped and brushed, so that the skin disinfectant is very convenient to use; moreover, the skin disinfectant disclosed by the invention can regulate and control the structural components of the disinfectant through the preparation method, so that the prepared disinfectant has a broad-spectrum bactericidal effect and is widely applied to the fields of biological medicine, express delivery and transportation, high-speed rail subway, public transport and other public industries.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. A skin sanitizer, characterized by: the skin disinfectant comprises the following components in percentage by weight:
a) Compound quaternary ammonium salt: 0.72 to 0.88 percent;
b) Glycerol: 0.01 to 0.05 percent;
c) At least one C2-C3 aliphatic alcohol: 0.9 to 1.1 percent;
d) Distilled or deionized water: and the balance.
2. A skin sanitizer according to claim 1, wherein: the compound quaternary ammonium salt consists of didecyl dimethyl ammonium chloride and benzalkonium chloride, and the weight percentages of the two components are as follows:
didecyl dimethyl ammonium chloride: 0.5 to 0.7 percent; benzalkonium chloride: 0.18 to 0.3 percent.
3. A skin disinfectant according to claim 2, wherein: the compound quaternary ammonium salt consists of didecyl dimethyl ammonium chloride and benzalkonium chloride, and the weight percentages of the two components are as follows:
didecyl dimethyl ammonium chloride: 0.52 percent; b) Benzalkonium chloride: 0.2 percent.
4. A skin sanitizer according to claim 1 or 2, wherein: the at least one C2-C3 aliphatic alcohol is ethanol, n-propanol or isopropanol or a mixture of any of the foregoing.
5. A skin sanitizer according to claim 1, 2 or 3, wherein: at least one C2-C3 aliphatic alcohol is ethanol.
6. A skin sanitizer according to claim 5, wherein: the ethanol is 75% ethanol.
7. A skin sanitizer according to claim 6, wherein: the skin disinfectant consists of the following components in percentage by weight: 0.70%, benzalkonium chloride: 0.18%, glycerin: 0.05%, ethanol: 1.1 percent and the balance of distilled water.
8. A skin sanitizer according to claim 1, wherein: the weight percentage of the distilled water or the deionized water is 98.0 percent to 98.3 percent.
9. A method of disinfecting skin comprising applying to a patient a skin disinfectant comprising a quaternary ammonium complex salt, glycerin, at least one C2-C3 aliphatic alcohol, and distilled or deionized water.
10. A method of disinfecting skin according to claim 9, wherein said skin disinfectant results in at least a 2 log reduction of bacteria, including e.coli, s.
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| CN202310027829.XA CN115969826A (en) | 2023-01-09 | 2023-01-09 | Skin disinfectant and method for disinfecting skin |
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