CN115501793A - Double-spiral passive micro mixer - Google Patents
Double-spiral passive micro mixer Download PDFInfo
- Publication number
- CN115501793A CN115501793A CN202211002158.3A CN202211002158A CN115501793A CN 115501793 A CN115501793 A CN 115501793A CN 202211002158 A CN202211002158 A CN 202211002158A CN 115501793 A CN115501793 A CN 115501793A
- Authority
- CN
- China
- Prior art keywords
- channel
- sub
- subchannel
- mixing
- channels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 239000012530 fluid Substances 0.000 description 21
- 238000009792 diffusion process Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000739 chaotic effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 2
- 239000011295 pitch Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
The invention provides a double-spiral passive micro mixer, which comprises an inlet channel, a mixing channel and an outlet channel, wherein the mixing channel comprises a plurality of mixing units which are sequentially connected, each mixing unit comprises a first sub-channel, a second sub-channel, a third sub-channel and a sheet, the first sub-channel, the second sub-channel and the third sub-channel are all the same in structure and are two circles of double-spiral channels, the inlet channel and the first sub-channel are connected through the sheet, and the first sub-channel, the second sub-channel and the third sub-channel are sequentially connected at an included angle of 65 degrees.
Description
Technical Field
The invention relates to the technical field of micro mixers, in particular to a double-spiral passive micro mixer.
Background
The microfluidic chip analysis can reduce the sample amount and shorten the reaction time, is easy to integrate, and has great application potential in the fields of life science, pharmaceutical analysis and chemical analysis. The micro mixer can realize the rapid and uniform mixing of samples in the micro channel or the micro cavity, is an important component of the micro-fluidic chip, and the mixing effect of the micro mixer directly influences the analysis performance of the micro-fluidic chip. Micromixers can be divided into active and passive types. Active mixers rely on external energy to enhance mixing. The passive mixer utilizes the change of the micro-channel structure to improve the mixing efficiency. Passive mixers are receiving increasing attention due to their low manufacturing cost, simple construction and lack of additional components. Therefore, the development of a passive micromixer with high mixing efficiency is of great significance to the microfluidic chip.
The development of passive micromixers has shifted from two-dimensional to three-dimensional structures. Compared with a two-dimensional micro mixer, the three-dimensional micro mixer has the advantage that the mixing efficiency is obviously improved. Research shows that microfluid mixing mainly depends on molecular diffusion and chaotic convection, and chaotic convection plays a leading role. The spiral-structure micro-channel can change the flow direction of fluid for many times, and more twists and vortexes can appear on the fluid interface, so that the disturbance and chaos characteristics of the fluid are increased, and the mixing efficiency is obviously higher than that of other structures.
Based on the above problems, the invention provides a double-spiral passive micro mixer, which comprises an inlet channel, a mixing channel and an outlet channel, wherein the mixing channel comprises a plurality of sequentially connected mixing units, each mixing unit comprises a first sub-channel, a second sub-channel, a third sub-channel and a sheet, the first sub-channel, the second sub-channel and the third sub-channel are identical in structure and are two circles of double-spiral channels, the inlet channel and the first sub-channel are connected through the sheet, and the first sub-channel, the second sub-channel and the third sub-channel are sequentially connected at an included angle of 65 degrees.
Disclosure of Invention
The invention aims to provide a double-helix passive micro mixer, which realizes uniform mixing of fluid to improve mixing efficiency.
In order to realize the purpose, the invention adopts the following technical scheme: the utility model provides a double helix type passive micromixer, its characterized in that, includes inlet channel, mixing channel and outlet channel, mixing channel includes a plurality of mixing unit that connect gradually, mixing unit includes first subchannel, second subchannel, third subchannel and thin slice, first subchannel, second subchannel and third subchannel structure all are the same, for two rings of double helix channels, inlet channel with pass through between the first subchannel the thin slice is connected, connect gradually between first subchannel, second subchannel and the third subchannel, first subchannel afterbody with second subchannel head links to each other, second subchannel afterbody links to each other with third subchannel head, third subchannel afterbody with pass through between the outlet channel the thin slice is connected, inlet channel's export place axis with outlet channel place axis collineation.
Further, preferably, the inlet channel is a T-shaped channel, and the substances to be mixed are injected from two ports of the T-shaped channel respectively.
Further, preferably, the size of the inlet channel is 300. Mu. M.times.300. Mu.m.
Further, preferably, the thickness of the sheet is 100 μm.
Further, preferably, the number of the mixing units is 3.
Further, preferably, the channel sizes of the first sub-channel, the second sub-channel and the third sub-channel are all the same.
Further, preferably, the stagger angle between the first sub-channel, the second sub-channel and the third sub-channel is 65 °.
Preferably, the double spiral passive micro mixer is made by casting polydimethylsiloxane in a mould.
The invention has the beneficial effects that:
the invention provides a double-spiral passive micro mixer, which comprises an inlet channel, a mixing channel and an outlet channel, wherein the mixing channel comprises a plurality of mixing units which are sequentially connected, each mixing unit comprises a first sub-channel, a second sub-channel, a third sub-channel and a sheet, the first sub-channel, the second sub-channel and the third sub-channel are all the same in structure and are two circles of double-spiral channels, the inlet channel and the first sub-channel are connected through the sheet, and the first sub-channel, the second sub-channel and the third sub-channel are sequentially connected at an included angle of 90 degrees.
Drawings
FIG. 1 is a schematic plan view of a micromixer according to the present invention;
FIG. 2 is a schematic three-dimensional structure of a micromixer according to the present invention;
FIG. 3 is a graph of mixing efficiency for different pitches of the mixing unit of the present invention;
FIG. 4 is a graph of mixing efficiency for different numbers of mixing units in accordance with the present invention;
FIG. 5 is a graph of mixing efficiency for different diameters of mixing units of the present invention;
FIG. 6 is a graph of mixing efficiency for different stagger angles of the mixing unit of the present invention;
wherein, 1, inlet channel, 2, sheet, 3, first subchannel, 4, second subchannel, 5, third subchannel, 6, sheet, 7, outlet channel.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings. It is to be understood, however, that the drawings are provided solely for the purposes of promoting an understanding of the invention and that they are not to be construed as limiting the invention.
As shown in fig. 1-6. The invention provides a double-spiral passive micro mixer which is characterized by comprising an inlet channel 1, a mixing channel and an outlet channel 7, wherein the mixing channel comprises a plurality of mixing units which are sequentially connected, the mixing units comprise a first sub-channel 3, a second sub-channel 4, a third sub-channel 5 and sheets 2 and 6, the first sub-channel 3, the second sub-channel 4 and the third sub-channel 5 are in the same structure and are double-spiral channels, the inlet channel 1 and the first sub-channel 3 are connected through the sheets 2, the first sub-channel 3, the second sub-channel 4 and the third sub-channel 5 are sequentially connected, the tail of the first sub-channel 3 is connected with the head of the second sub-channel 4, the tail of the second sub-channel 4 is connected with the head of the third sub-channel 5, the tail of the third sub-channel 5 is connected with the outlet channel 7 through the sheets 6, and the axis of an outlet of the inlet channel 1 is collinear with the axis of the outlet channel 7.
In this embodiment, the inlet channel 1 is a T-shaped channel, and the substances to be mixed are injected from two ports of the T-shaped channel respectively.
Meanwhile, the size of the inlet channel 1 is 300. Mu. M.times.300. Mu.m.
In order to ensure the connection between the inlet channels 1, the outlet channels 7 and the mixing channels without affecting the size of the chip, the thickness of the lamellae 2, 6 is 100 μm.
In this invention, the number of the mixing units is 3 in order to ensure the highest mixing efficiency.
In this invention, the channel sizes of the first sub-channel 3, the second sub-channel 4 and the third sub-channel 5 are all the same.
In the invention, in order to ensure the highest mixing efficiency, the staggered angle among the first sub-channel 3, the second sub-channel 4 and the third sub-channel 5 is 65 degrees.
In the invention, the double-spiral passive micro mixer is cast in a mould by adopting polydimethylsiloxane.
In the invention, on the premise of different turns, when the fluid reaches the initial position of the spiral, turbulent flow is generated, the turns are increased, the mixing and diffusion area of the fluid is enhanced, and when the fluid flows through more spiral structures, the acting force among fluid molecules can be ensured to be fully damaged.
In the invention, on the premise of different thread pitches, the geometrical structure of the fillet turning has a transitional circular arc, which lengthens the mixing area of the fluid, so the duration of the promotion action of the fluid on mixing is more, and in addition, the area of secondary backflow generated by the fillet turning is larger; in terms of microstructure, the spiral structure enables fluid to generate turbulence, the larger the structural change of a channel through which the fluid flows is, the more favorable the damage to intermolecular force is, and the secondary backflow enables the molecules to become more disordered and the more favorable the mixing of the fluids.
In the present invention, it is preferable that,
in the formula, delta L is the channel length and is a fixed value, xi represents the mixing efficiency, theta is a circular angle, and when theta is increased, the mixing efficiency is reduced; conversely, when θ is decreased, the mixing efficiency increases.
In the invention, on the premise of different diameters, the length of the channel of the micro mixer is not changed, the contact area of the fluid is increased along with the increase of the diameter of the channel of the micro mixer, the contact time between molecules is longer, and the mixing efficiency is improved.
In the invention, on the premise of different interleaving angles, on the basis of two-dimensional plane branches, interleaving in the depth direction of a flow channel is introduced to form a three-dimensional channel interleaving structure, a main channel of the three-dimensional channel interleaving structure is divided into two sub-channels, and internal fluid is divided and recombined, so that the two functions of multilayer diffusion and chaotic advection are combined, the redistribution degree and range of a velocity field are increased, the diffusion effect of the fluid is enhanced, and the mixing efficiency is improved.
In the invention, on the premise of different flow rates, in macroscopic view, along with the increase of the flow rate, the fluid has higher speed, the pressure intensity of the fluid in the spiral structure is increased, and the collision effect of the fluid in the channel is stronger; microscopically, intermolecular forces of the fluid are accelerated and destroyed. Furthermore, the frequency of the vortex forming a small area of fluid within the spiral channel increases, and then the mixing efficiency increases.
The micro mixer comprises an inlet channel, a mixing channel and an outlet channel, wherein the mixing channel comprises a plurality of mixing units which are sequentially connected, the mixing units comprise a first sub-channel, a second sub-channel, a third sub-channel and a sheet, the first sub-channel, the second sub-channel and the third sub-channel are identical in structure and are double-circle double-helix channels, the inlet channel and the first sub-channel are connected through the sheet, and the first sub-channel, the second sub-channel and the third sub-channel are sequentially connected at an included angle of 65 degrees.
The above embodiments are only for illustrating the invention and are not to be construed as limiting the invention, and those skilled in the art of processing engineering can make various changes and modifications without departing from the spirit and scope of the invention, therefore, all equivalent technical solutions also belong to the scope of the invention, and the scope of the invention is defined by the claims.
Claims (8)
1. The utility model provides a double helix type passive micromixer, its characterized in that, includes inlet channel, mixing channel and outlet channel, mixing channel includes a plurality of mixing unit that connect gradually, mixing unit includes first subchannel, second subchannel, third subchannel and flake, first subchannel, second subchannel and third subchannel structure are the same, inlet channel with pass through between the first subchannel the flake is connected, connect gradually between first subchannel, second subchannel and the third subchannel, first subchannel afterbody with the second subchannel head links to each other, second subchannel afterbody links to each other with the third subchannel head, third subchannel afterbody with pass through between the outlet channel the flake is connected, inlet channel's export place axis with outlet channel place axis collineation.
2. The double helix passive micromixer according to claim 1, wherein the inlet channels are T-channels, and the substances to be mixed are injected from two ports of the T-channels, respectively.
3. A double helix passive micromixer according to claim 1, in which the dimensions of the inlet channels are 300 μm by 300 μm.
4. A double helix passive micromixer according to claim 1, characterized in that the thickness of the lamellae is 100 μm.
5. A double helix passive micromixer according to claim 1, characterized in that the number of mixing units is 3.
6. The double helix passive micromixer according to claim 1, wherein the channel dimensions of the first, second and third sub-channels are all the same.
7. A double helix passive micromixer according to claim 1, wherein the stagger angle between the first, second and third sub-channels is 65 °.
8. The double helix passive micromixer according to claim 1, wherein it is cast in a mold using polydimethylsiloxane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211002158.3A CN115501793A (en) | 2022-08-21 | 2022-08-21 | Double-spiral passive micro mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211002158.3A CN115501793A (en) | 2022-08-21 | 2022-08-21 | Double-spiral passive micro mixer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115501793A true CN115501793A (en) | 2022-12-23 |
Family
ID=84501985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211002158.3A Pending CN115501793A (en) | 2022-08-21 | 2022-08-21 | Double-spiral passive micro mixer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115501793A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110096327A1 (en) * | 2009-09-24 | 2011-04-28 | University Of Cincinnati | Spiral Microchannel Particle Separators, Straight Microchannel Particle Separators, and Continuous Particle Separator and Detector Systems |
| CN103638853A (en) * | 2013-11-11 | 2014-03-19 | 江苏大学 | S-type passive micro-mixer |
| CN104069767A (en) * | 2013-03-29 | 2014-10-01 | 索尼公司 | Microfluidic channel and microfluidic device |
| CN104923323A (en) * | 2015-07-02 | 2015-09-23 | 东南大学 | Micron particle concentrating device with low cost and manufacturing method of micron particle concentrating device |
| CN106540758A (en) * | 2016-10-21 | 2017-03-29 | 北京保利星数据光盘有限公司 | Micro-fluidic chip |
| CN106732111A (en) * | 2017-01-03 | 2017-05-31 | 江苏大学 | A kind of type recombined micro-mixer of D types non-axisymmetrical separation |
| CN108196053A (en) * | 2017-12-28 | 2018-06-22 | 无锡准因生物科技有限公司 | A kind of microfluidic device and its manufacturing method for capturing leucocyte |
| KR20180105980A (en) * | 2017-03-16 | 2018-10-01 | 한국과학기술원 | Screw micro reactor |
| CN208878529U (en) * | 2018-03-29 | 2019-05-21 | 睦化(上海)流体工程有限公司 | Micropore is vortexed casing mixing reactor |
-
2022
- 2022-08-21 CN CN202211002158.3A patent/CN115501793A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110096327A1 (en) * | 2009-09-24 | 2011-04-28 | University Of Cincinnati | Spiral Microchannel Particle Separators, Straight Microchannel Particle Separators, and Continuous Particle Separator and Detector Systems |
| CN104069767A (en) * | 2013-03-29 | 2014-10-01 | 索尼公司 | Microfluidic channel and microfluidic device |
| CN103638853A (en) * | 2013-11-11 | 2014-03-19 | 江苏大学 | S-type passive micro-mixer |
| CN104923323A (en) * | 2015-07-02 | 2015-09-23 | 东南大学 | Micron particle concentrating device with low cost and manufacturing method of micron particle concentrating device |
| CN106540758A (en) * | 2016-10-21 | 2017-03-29 | 北京保利星数据光盘有限公司 | Micro-fluidic chip |
| CN106732111A (en) * | 2017-01-03 | 2017-05-31 | 江苏大学 | A kind of type recombined micro-mixer of D types non-axisymmetrical separation |
| KR20180105980A (en) * | 2017-03-16 | 2018-10-01 | 한국과학기술원 | Screw micro reactor |
| CN108196053A (en) * | 2017-12-28 | 2018-06-22 | 无锡准因生物科技有限公司 | A kind of microfluidic device and its manufacturing method for capturing leucocyte |
| CN208878529U (en) * | 2018-03-29 | 2019-05-21 | 睦化(上海)流体工程有限公司 | Micropore is vortexed casing mixing reactor |
Non-Patent Citations (3)
| Title |
|---|
| DONG BIQIN,ET.AL: "Real-time Functional Analysis of Inertial Microfluidic Devices via Spetral Domain Optical Coherence Tomography", SCIENTIFIC REPORTS, vol. 6, pages 33250 * |
| KEYIN LIU,ET.AL: "Design and analysis of the cross-linked dual helical micromixer for rapid mixing at low Reynolds numbers", MICROFLUIDICS AND NANOFLUIDICS, vol. 19, pages 169 - 180 * |
| 严圣勇: "基于近场熔体静电纺丝的微流控芯片的设计、制作及应用", 中国优秀硕士学位论文全文数据库, no. 3, pages 1 - 75 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lee et al. | Passive mixers in microfluidic systems: A review | |
| CN103638853B (en) | A kind of S type passive type micro-mixer | |
| CN109261036B (en) | Microstructure mixer for mixing high-viscosity fluid | |
| CN110090607B (en) | Micro-reactor | |
| CN105664773A (en) | Planar passive micromixer | |
| KR101432729B1 (en) | Micromixer with circular chambers and crossing constriction channels | |
| CN103877905B (en) | A kind of passive type micro-mixer | |
| CN105771765B (en) | A kind of passive type micro-mixer of built-in periodicity stop block and baffle plate | |
| CN207446125U (en) | A kind of passive microfluid mixer | |
| CN111974290A (en) | Taiji-shaped passive micro mixer | |
| CN109985543B (en) | Spindle-shaped passive micro mixer | |
| CN113083056A (en) | Butterfly type static mixer | |
| CN115501793A (en) | Double-spiral passive micro mixer | |
| CN107051304A (en) | A kind of active electric osmose micro-mixer of unsymmetric structure and electrode | |
| CN104154798A (en) | Novel plane micro-channel heat exchanger | |
| CN110975776B (en) | Microfluid mixing channel, microfluid control device and microreactor | |
| CN101716473B (en) | Chip-in micro-mixer and preparation method thereof | |
| Wu et al. | Numerical study of the passive micromixer with the novel blocks | |
| CN216654603U (en) | Micro-fluidic chip, hybrid system and biological detection equipment | |
| CN214159412U (en) | Active and passive type round channel microfluid mixer | |
| CN107233833B (en) | Ultrafast microflow mixer with viscosity adaptability | |
| CN103638837A (en) | Piezoelectric micromixer based on synthesis jet | |
| CN115283034B (en) | Micro-fluidic chip based on light-temperature coupling response hydrogel | |
| CN113842824B (en) | Passive micromixer for enhancing mixing efficiency based on composite side wall microstructure | |
| CN215138727U (en) | Butterfly type static mixer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20221223 |
|
| WD01 | Invention patent application deemed withdrawn after publication |