CN115501481A

CN115501481A - Emergency program control equipment, medical system and computer readable storage medium

Info

Publication number: CN115501481A
Application number: CN202211184468.1A
Authority: CN
Inventors: 王倩; 周国新
Original assignee: Sceneray Co Ltd
Current assignee: Sceneray Co Ltd
Priority date: 2022-09-27
Filing date: 2022-09-27
Publication date: 2022-12-23

Abstract

An emergency programming device, a medical system, and a computer readable storage medium are provided, the emergency programming device including a processor configured to implement the steps of: sensing electrophysiological activities of a patient by utilizing a stimulator implanted in the corresponding patient to obtain electrophysiological signals of the patient when an active program control request sent by an emergency call terminal is received; obtaining a state classification result corresponding to the patient; when the condition of the patient is not controlled, forwarding the active programming request to a plurality of physician programming devices so that a target physician programming device establishes a programming connection with the stimulator; and receiving the program control operation input by the target doctor by using the target doctor program control equipment to generate a corresponding program control command. Only when the patient's condition is uncontrolled, the active programming request is forwarded to establish a programming connection, reducing the possibility of misuse of emergency programming functions due to false triggering of emergency call operations.

Description

Emergency program control device, medical system and computer readable storage medium

Technical Field

The application relates to the technical field of implantable devices, deep brain electrical stimulation and deep learning, in particular to emergency program control equipment, a medical system and a computer readable storage medium.

Background

With the development of science and technology and the progress of society, patients desire to improve the quality of life through various treatment means, wherein the application prospect of medical devices, especially implantable devices, is very wide. Implantable devices are medical devices that are introduced into the body or into a lumen (orifice) by surgery, either in whole or in part, or used to replace the epithelial surface or ocular surface of the body, and remain in the body for more than 30 days (inclusive) after the surgical procedure is completed, or are absorbed by the body. A stimulator is one of the Implantable devices, and generally includes an IPG (Implantable Pulse Generator), an extension lead and an electrode lead, which can provide a patient with parameter-controllable refined electrical stimulation therapy, and is popular in the market among many consumers.

At present, the program control aiming at the stimulator needs a patient to make an appointment in advance for several days or several weeks, and if the patient breaks through symptoms such as physical rigor and the like at midnight and seriously influences life, the patient can not be hospitalized in time to cause the disease deterioration.

Patent CN114781516A discloses an emergency program control device, method, system and computer readable storage medium, said emergency program control device being configured to: receiving a trigger operation by utilizing interactive equipment; in response to the triggering operation, obtaining identification information of a stimulator, the identification information including at least one of a stimulator identification and a patient identification, the stimulator for implanting within a patient to deliver therapy to the patient or to sense electrical activity; sending a programming request to a patient programmer to establish a programming connection between a physician programmer and the stimulator, the programming request including the identification information. Through the emergency program control equipment, the emergency program control equipment responds to the triggering operation, so that the aspect of the patient can actively seek to establish the emergency program control connection between the doctor program control equipment and the stimulator. However, the emergency programming device allows the programmed connection between the physician programmer and the stimulator to be established without detecting the real-time status of the patient, with the potential for false triggering of emergency call operation resulting in abuse of the emergency programming function.

Based on this, the present application provides an emergency program control device, a medical system and a computer readable storage medium to solve the above-mentioned problems in the prior art.

Disclosure of Invention

The application aims to provide an emergency program control device, a medical system and a computer readable storage medium, aiming at an active program control request sent by an emergency call terminal, the real-time state of a patient is obtained, and only when the condition of the patient is not controlled, the active program control request is forwarded to establish program control connection, so that the possibility of misusing an emergency program control function caused by mistakenly triggering an emergency call operation is reduced.

The purpose of the application is realized by adopting the following technical scheme:

in a first aspect, the present application provides an emergency programming device comprising a processor configured to implement the steps of:

sensing electrophysiological activities of a patient by utilizing a stimulator implanted in the corresponding patient to obtain electrophysiological signals of the patient when an active program control request sent by an emergency call terminal is received;

acquiring a corresponding state classification result of the patient based on the electrophysiological signal of the patient;

when the state classification result corresponding to the patient is used for indicating that the patient's condition is not controlled, forwarding the active programming request to a plurality of physician program-controlled devices so as to enable a target physician program-controlled device to establish a program-controlled connection with the stimulator, wherein the target physician program-controlled device is one of the plurality of physician program-controlled devices;

receiving a program control operation input by a target doctor by using the target doctor program control equipment to generate a corresponding program control command and sending the program control command to the stimulator so that the stimulator delivers the electrical stimulation corresponding to the program control command to the internal tissues of the patient.

The technical scheme has the beneficial effects that: the real-time state of the patient is acquired according to the active program control request sent by the emergency call terminal, and the active program control request is forwarded to establish program control connection only when the illness state of the patient is not controlled, so that the possibility of misusing the emergency program control function due to mistaken triggering of emergency call operation is reduced.

Specifically, when the emergency program control device receives an active program control request sent by an emergency call terminal, the active program control request is not forwarded at the first time, but an electrophysiological signal is obtained by sensing the electrophysiological signal through a stimulator at first, the obtained electrophysiological signal can be used for classifying the real-time state of the patient to obtain a state classification result, and the state classification result is used for indicating whether the condition of the patient is controlled; when the illness state of the patient is not controlled, the emergency program control equipment can simultaneously forward the active program control request to a plurality of doctor program control equipment so as to enable one of the doctor program control equipment to establish program control connection with the stimulator; and then receiving the program control operation input by the target doctor by using the program control equipment of the target doctor, generating a corresponding program control command and sending the program control command to the stimulator, so that the stimulator is used for delivering the electrical stimulation corresponding to the program control command to the internal tissues of the patient. The programming operation may be, for example, an operation of configuring stimulation parameters of a stimulator, and the programming instructions may be, for example, used to configure the stimulation parameters of the stimulator.

Although the emergency programmable device in the prior art can acquire the health monitoring data of the patient and the corresponding type of call for help, the function is only to control the alarm device to give an alarm to expand the influence and promote the rescue action of the surrounding personnel on the patient, and not to serve as a judgment condition for establishing the programmable connection. In other words, for the emergency programming device, the programming connection must be established as soon as a triggering operation is received. When the emergency program control device receives an active program control request sent by an emergency program control terminal, a judgment step is set for judging whether the active program control request is forwarded or not, specifically, electrophysiological activities of a patient are sensed in real time to obtain real-time electrophysiological signals, the state classification results of the patient are obtained by using the electrophysiological signals obtained in real time, and the active program control request is forwarded only when the state of an illness of the patient is not controlled (for example, the patient is in a state of being about to suffer from illness, suffering from illness or having life risks), so that program control connection between the target doctor program control device and a stimulator is established, stimulation parameters of the stimulator are configured by using the target doctor program control device, and timely and accurate electrical stimulation treatment is provided for the patient by using the stimulator. When the state of illness of the patient is controlled (for example, the patient is in a state of no illness or normal health condition), even if the emergency program control equipment receives the active program control request of the emergency call terminal, the active program control request is not forwarded. Therefore, the emergency program control equipment in the application is adopted to carry out targeted transfer on the active program control request (based on the real-time state of the patient), the possibility of misusing the emergency program control function caused by mistakenly triggering the emergency call operation of the emergency call terminal can be reduced, the emergency program control function is prevented from being occupied by the mistaken operation, and limited medical resources can serve the patient who really has the need or has the most urgent and urgent need.

In some optional embodiments, the processor is configured to generate the programmed instructions by:

acquiring first parameter configuration information corresponding to the program control operation and sending the first parameter configuration information to other doctor program control equipment in the plurality of doctor program control equipment;

receiving confirmation operation or objection operation input by other doctors by using other doctor program control equipment;

and in a preset time length, when the number of the received confirmation operations is not less than a first preset number or the number of the received objection operations is not more than a second preset number, generating a program control instruction corresponding to the program control operation by using the program control equipment of the target doctor.

The technical scheme has the beneficial effects that: in the prior art, after the target doctor program control device is connected with the stimulator in a program control mode, the target doctor usually only uses the target doctor program control device to program the stimulator, other doctors are not involved, and functions similar to consultation cannot be provided. However, when the patient's condition is complex or even life-threatening, a single physician may not have sufficient ability to provide an optimal solution in a short period of time. Therefore, although only the target doctor program-controlled device establishes the program-controlled connection with the stimulator, the first parameter configuration information corresponding to the program-controlled operation of the target doctor can be synchronously transmitted to other doctor program-controlled devices, so that other doctors can check whether the stimulation parameters configured by the target doctor are accurate and reasonable or not, and a function similar to voting is provided for other doctors.

Within a preset time period, other doctors can confirm or make an objection to the programmed operation of the target doctor.

If other doctors feel that the stimulation parameters configured by the target doctor are reasonable and reliable, the other doctors can input confirmation operation through the corresponding doctor program control equipment to confirm the stimulation parameters configured by the target doctor, in other words, the other doctors also confirm the program control operation of the target doctor;

if other doctors feel that the stimulation parameters configured by the target doctor are not reasonable, the other doctors can input objection operation through the corresponding doctor programming equipment to propose objection to the stimulation parameters configured by the target doctor, in other words, to propose objection to the programming operation of the target doctor.

Within a preset time length, as long as enough votes of other doctors are confirmed or only few votes of other doctors are voted to put out an objection, the program control operation of the target doctor can be considered to have higher reliability, and then a corresponding program control instruction can be generated based on the program control operation of the target doctor; however, if the number of tickets to be confirmed is too small or the number of tickets to be objected is too large, the reliability of the program control operation of the target doctor can be considered to be undetermined, and the corresponding program control instruction cannot be generated directly based on the program control operation of the target doctor.

The voting mechanism is introduced in the program control process of the target doctor for the patient, and the opinions of other doctors are referred, so that the situation that a single target doctor makes a decision independently is avoided, the program control operation is reasonable and reliable, more accurate electrical stimulation treatment can be provided for the patient, and doctor-patient disputes are reduced.

In some alternative embodiments, the processor is further configured to generate the programming instructions by:

within the preset time length, when the number of the received confirmation operations is smaller than the first preset number or the number of the received objection operations is larger than the second preset number, inputting the electrophysiological signals into a parameter configuration model to obtain predicted parameter configuration information corresponding to the electrophysiological signals;

acquiring first similarity between the first parameter configuration information and the prediction parameter configuration information;

and when the first similarity is not smaller than a preset similarity threshold value, generating a program control instruction corresponding to the program control operation by using the program control equipment of the target doctor.

The technical scheme has the beneficial effects that: if the number of tickets to be confirmed is too small or the number of tickets for which an objection is proposed is too large, it can be considered that the reliability of the program control operation of the target doctor is undetermined, a corresponding program control instruction is not generated directly based on the program control operation of the target doctor, but an intelligent automatic determination (secondary determination) is started on the reliability of the program control operation of the target doctor.

Specifically, firstly, a parameter configuration model is used for intelligently acquiring prediction parameter configuration information corresponding to a real-time electrophysiological signal of a patient, the trained parameter configuration model generally has higher accuracy, and the reliability of the prediction parameter configuration information is relatively guaranteed; then similarity calculation is carried out on the first parameter configuration information and the predicted parameter configuration information predicted by the parameter configuration model so as to obtain a first similarity between the first parameter configuration information and the predicted parameter configuration information; and comparing the first similarity with a preset similarity threshold, wherein when the first similarity is greater than or equal to the preset similarity threshold, the first parameter configuration information corresponding to the program control operation of the target doctor is higher in similarity with the predicted parameter configuration information predicted by the parameter configuration model, the program control operation of the target doctor can be considered to be reliable, the secondary judgment is passed, and then a corresponding program control instruction can be generated based on the program control operation of the target doctor.

The method has the advantages that the parameter configuration model is used for providing the predicted parameter configuration information, the mode of combining intelligence (parameter configuration model) and manual work (other doctors) is adopted, the sequence is divided, the reliability of the program control operation of the target doctor is judged, the judgment mode can give consideration to higher accuracy and efficiency, and the method is suitable for the actual situation that the patient's condition is complicated and changeable. On one hand, in the first stage, the reliability of the program control operation of the target doctor is manually judged (one-time judgment), and when the program control operation of the target doctor is supported by enough manual votes from other doctors, the program control operation of the target doctor can be considered to be reliable; on the other hand, when the program control operation of the target doctor is not supported by enough manual voting, the program control operation is not directly judged to be unreliable, but the second stage judgment process (secondary judgment) is carried out, the reliability of the program control operation of the target doctor is intelligently judged, namely, the similarity calculation is carried out by utilizing the predicted parameter configuration information predicted by the parameter configuration model and the first parameter configuration information corresponding to the program control operation, and then whether the program control operation is reliable or not is judged according to the size relationship between the first similarity and the preset similarity threshold. Therefore, the method has the advantages of high efficiency of intelligent judgment and wide application range of manual judgment.

In some optional embodiments, the processor is further configured to generate the programmed instructions by:

when the first similarity is smaller than the preset similarity threshold, prompting other corresponding doctors to input second parameter configuration information by using other doctor program control equipment which receives objection operation so as to obtain one or more second parameter configuration information;

acquiring a second similarity between each second parameter configuration information and the prediction parameter configuration information;

and when the maximum value of the second similarity is not less than the preset similarity threshold value, generating a program control command corresponding to second parameter configuration information corresponding to the maximum value of the second similarity by using the program control equipment of the target doctor.

The technical scheme has the beneficial effects that: in the first stage, other doctors confirm the program control operation of the target doctor less or propose more objections, so that the reliability of the program control operation is intelligently judged in the second stage, and the first similarity between the first parameter configuration information of the target doctor and the predicted parameter configuration information is found to be smaller than the preset similarity threshold in the second stage, so that the reliability of the program control operation of the target doctor cannot be confirmed through two judgment rounds, and more support needs to be provided by other doctors.

At this time, other doctors who need to make an objection give own professional advice, namely, provide second parameter configuration information approved by themselves. Next, in order to improve the efficiency of the program control process and ensure that the patient can be treated in time, second parameter configuration information of each of the disagreeable doctors is not required to be pushed to each other, but predicted parameter configuration information predicted by the parameter configuration model is continuously used as reference, a second similarity between each piece of second parameter configuration information and the predicted parameter configuration information is calculated, when a maximum value of the second similarity reaches a standard (that is, is not less than a preset similarity threshold), a program control instruction is generated based on the second parameter configuration information corresponding to the maximum value of the second similarity, and the generated program control instruction is used for configuring stimulation parameters of a stimulator and performing electrical stimulation treatment on the patient. This has the advantage that when the reliability of the target physician's programming operation cannot be confirmed, other physicians provide parameter configuration information, but the other physician programming devices do not need to establish a programming connection with the stimulator, and continue to transmit programming commands by directly using the connected target physician programming device, except that the transmitted programming commands correspond to the second parameter configuration information provided by the other physicians. On one hand, the second parameter configuration information with higher reliability provided by other doctors can be adopted, and the electrical stimulation treatment effect on the patient is improved; on the other hand, the time for establishing program-controlled connection between other doctor program-controlled equipment and the stimulator is saved, the treatment efficiency is improved, the pain of the patient is relieved quickly, and the life safety of the patient is guaranteed.

In some optional embodiments, the process of acquiring the patient corresponding to the emergency call terminal includes:

analyzing the active program control request to acquire identification information of the patient and/or identification information of the stimulator;

and determining the patient corresponding to the emergency call terminal based on the identification information of the patient and/or the identification information of the stimulator.

The technical scheme has the beneficial effects that: the active programming request sent by the emergency call terminal may carry identification information of the patient and/or identification information of the stimulator, so that the corresponding patient can be determined. The emergency call terminal may bind one or more patients. When a patient is bound, the active program control request sent each time carries fixed identification information corresponding to the patient; when a plurality of patients are bound, the patients currently in need of emergency programming need to be manually determined when the active programming request is sent, for example, a manual interaction operation may be received by using an emergency call terminal to select one of the patients, and the interaction operation may be an operation of inputting a patient identifier, manually selecting a patient from a preset patient list, identifying a patient, and the like.

In some optional embodiments, the processor is further configured to implement the steps of:

and after the target doctor program control equipment establishes program control connection with the stimulator, sending prompt information to other doctor program control equipment in the plurality of doctor program control equipment, wherein the prompt information is used for indicating that the doctor has responded in the active program control request.

The technical scheme has the beneficial effects that: when the target doctor program-controlled equipment establishes program-controlled connection with the stimulator, the target doctor is indicated to receive the task of emergency treatment of the patient, and the progress is informed to other doctors, so that the condition that the information of other doctors is still asymmetric is avoided. Otherwise, other doctors can only receive the distress signal of the active program control request, do not know whether the patient is treated or not, and can only judge that the emergency situation is eliminated by no longer receiving the distress signal, which may cause great psychological burden to the doctors and influence the enthusiasm of the doctors for participating in emergency program control.

the stimulator is restricted in parallel so that it can be programmed with at most one physician programming device.

The technical scheme has the beneficial effects that: only one doctor program control device is connected with the stimulator in a program control mode at the same time, only one doctor can perform program control on a patient at the same time (no matter off-line program control or remote program control), and the mutual interference of program control commands sent by a plurality of doctor program control devices, the treatment effect is prevented from being influenced, and even the life safety of the patient is damaged.

after the target doctor program-controlled device establishes program-controlled connection with the stimulator, parameter configuration information of the latest N program-controlled processes corresponding to the patient is sent to the target doctor program-controlled device to assist the target doctor to execute the program-controlled operation, wherein N is a positive integer.

The technical scheme has the beneficial effects that: when the target doctor performs program control, parameter configuration information of the patient in the past program control process can be provided as reference to assist the target doctor to execute program control operation, so that the target doctor can conveniently know the acceptance degree and tolerance degree of the patient to various stimulation parameters of electrical stimulation treatment, and the program control efficiency of the target doctor is improved.

sending the electrophysiological signals, the state classification results corresponding to the patient and the parameter configuration information corresponding to the program control instruction to a preset storage position; and/or the presence of a gas in the gas,

acquiring video information of the patient by using a camera and sending the video information to the preset storage position; and/or the presence of a gas in the atmosphere,

acquiring voice information of the patient by using a microphone and sending the voice information to the preset storage position; and/or the presence of a gas in the atmosphere,

and sending the medicine information corresponding to the disease of the patient and the positioning information of the patient to third-party platform equipment so that the delivery robot corresponding to the third-party platform equipment delivers the medicine corresponding to the medicine information to the positioning information.

The technical scheme has the beneficial effects that: storing the electrophysiological signals acquired at this time, the corresponding state classification results thereof and the parameter configuration information corresponding to the program control instruction at this time, and using the stored electrophysiological signals for the subsequent data processing process; the video information and/or the voice information of the patient are/is stored, so that the treatment process can be traced intuitively and conveniently; the emergency program control equipment, the third-party platform equipment and the distribution robot thereof are utilized to provide the on-line medicine purchasing function based on the positioning information, so that the patient can quickly acquire the medicine corresponding to the disease of the patient, and the life safety of the patient is further guaranteed.

In a second aspect, the present application provides a medical system comprising:

a stimulator for implanting in a patient, sensing electrophysiological activity of the patient for electrophysiological signals, and delivering electrical stimulation to in vivo tissue of the patient;

the emergency call terminal is used for receiving emergency call operation to generate an active program control request;

any one of the above emergency programming devices.

In some alternative embodiments, the emergency call terminal and the emergency programming device are integrated; and/or the presence of a gas in the atmosphere,

the emergency call terminal is provided with one or more of a call button, a rotary switch, a sliding switch, a microphone assembly and a camera assembly;

the rotary switch is provided with a calling gear;

the sliding switch is provided with a calling gear;

the microphone assembly is provided with a microphone and a voice recognition chip;

the camera assembly is provided with a camera and an image recognition chip.

In some alternative embodiments, the emergency programming device and the stimulator are integrated.

In some alternative embodiments, the person triggering the emergency call operation is either the patient or a care-giver.

In some alternative embodiments, the disease of the patient comprises at least one of:

spasmodic disorders, depression, bipolar disorder, anxiety disorders, post-traumatic stress disorder, obsessive-compulsive disorder, behavioral disorders, mood disorders, memory disorders, mental state disorders, tremors, parkinson's disease, huntington's disease, alzheimer's disease, addictive disorders and autism.

In a third aspect, the present application provides a computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements the functionality of any of the pulse generators described above.

Drawings

The present application is further described below with reference to the drawings and embodiments.

Fig. 1 shows a block diagram of a medical system according to an embodiment of the present application.

Fig. 2 shows a schematic flow chart of an emergency program control method according to an embodiment of the present application.

Fig. 3 shows a schematic flowchart of generating a program control instruction according to an embodiment of the present application.

Fig. 4 shows a block diagram of an emergency program control device according to an embodiment of the present application.

Fig. 5 shows a schematic structural diagram of a program product provided in an embodiment of the present application.

Detailed Description

The technical solutions in the present application will be described below with reference to the drawings and the detailed description of the present application, and it should be noted that, in the present application, new embodiments can be formed by any combination of the following described embodiments or technical features without conflict.

In the embodiments of the present application, "at least one" means one or more, and "a plurality" means two or more. "and/or" describes the association relationship of the associated objects, meaning that there may be three relationships, e.g., a and/or B, which may mean: a exists alone, A and B exist simultaneously, and B exists alone, wherein A and B can be singular or plural. The character "/" generally indicates that the former and latter associated objects are in an "or" relationship. "at least one of the following" or similar expressions refer to any combination of these items, including any combination of the singular or plural items. For example, at least one (one) of a, b, or c, may represent: a, b, c, a and b, a and c, b and c, a and b and c, wherein a, b and c can be single or multiple. It is to be noted that "at least one item" may also be interpreted as "one or more item(s)".

It should also be noted that in the embodiments of the present application, words such as "exemplary" or "for example" are used to indicate examples, illustrations or descriptions. Any embodiment or design described herein as "exemplary" or "such as" is not necessarily to be construed as preferred or advantageous over other embodiments or designs. Rather, use of the word "exemplary" or "such as" is intended to present concepts related in a concrete fashion.

In the following, a brief description of one of the application areas (i.e. implantable devices) of the embodiments of the present application will be given first.

An implantable neurostimulation system (an implantable medical system) generally includes a stimulator implanted in a patient and a programming device disposed outside the patient. The existing nerve regulation and control technology is mainly characterized in that an electrode is implanted in a specific structure (namely a target spot) in a body through a three-dimensional directional operation, and a stimulator implanted in the body of a patient sends an electric pulse to the target spot through the electrode to regulate and control the electric activity and the function of a corresponding nerve structure and network, so that symptoms are improved, and pain is relieved. The stimulator may be any one of an Implantable nerve electrical stimulation device, an Implantable cardiac electrical stimulation System (also called a cardiac pacemaker), an Implantable Drug Delivery System (I DDS for short), and a lead switching device. Examples of the implantable neural electrical Stimulation device include Deep Brain Stimulation (DBS), cortical Brain Stimulation (CNS), spinal Cord Stimulation (SCS), sacral Nerve Stimulation (SNS), and Vagal Nerve Stimulation (VNS).

The stimulator may include an IPG (implantable pulse generator) disposed in the patient's body, an extension lead and an electrode lead, and provides controllable electrical stimulation energy to the body tissue by means of a sealed battery and a circuit in response to a programmed command transmitted from a programmed device, and delivers one or two controllable specific electrical stimulations to a specific region of the body tissue through the implanted extension lead and the electrode lead. The extension lead is used in cooperation with the IPG and is used as a transmission medium of the electrical stimulation signal to transmit the electrical stimulation signal generated by the IPG to the electrode lead. The electrode leads deliver electrical stimulation to specific areas of tissue within the body through a plurality of electrode contacts. The stimulator is provided with one or more paths of electrode leads on one side or two sides, a plurality of electrode contacts are arranged on the electrode leads, and the electrode contacts can be uniformly arranged or non-uniformly arranged on the circumference of the electrode leads. As an example, the electrode contacts may be arranged in an array of 4 rows and 3 columns (12 electrode contacts in total) in the circumferential direction of the electrode lead. The electrode contacts may include stimulation electrode contacts and/or collection electrode contacts. The electrode contact may have a sheet shape, an annular shape, a dot shape, or the like.

In some alternative embodiments, the stimulated in vivo tissue may be brain tissue of the patient, and the stimulated site may be a specific site of the brain tissue. The sites stimulated are generally different when the patient's disease type is different, as are the number of stimulation contacts (single or multiple) used, the application of one or more (single or multiple) specific electrical stimulation signals, and stimulation parameter data. The present embodiment is not limited to the type of disease applicable, and may be the type of disease applicable to Deep Brain Stimulation (DBS), spinal Cord Stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. Among the types of diseases that DBS may be used for treatment or management include, but are not limited to: convulsive disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., major Depressive Disorder (MDD)), manic depression, anxiety, post-traumatic stress disorder, depression, obsessive Compulsive Disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or parkinson's disease), huntington's disease, alzheimer's disease, drug addiction, autism, or other neurological or psychiatric diseases and injuries.

In the embodiment of the application, when the program control device is connected with the stimulator in a program control manner, the program control device can be used to adjust the stimulation parameters of the stimulator (different electrical stimulation signals corresponding to different stimulation parameters are different), the stimulator can sense the electrophysiological activity of a patient to acquire an electrophysiological signal, and the stimulation parameters of the stimulator can be continuously adjusted through the acquired electrophysiological signal.

The stimulation parameters may include at least one of: electrode contact identification for delivering electrical stimulation (e.g., can be # 2 electrode contact and # 3 electrode contact), frequency (e.g., number of electrical stimulation pulse signals per unit time of 1s in Hz), pulse width (duration of each pulse in μ s), amplitude (typically expressed as voltage, i.e., intensity of each pulse in V), timing (e.g., can be continuous or clustered, which refers to a discontinuous timing behavior made up of multiple processes), stimulation pattern (including one or more of current pattern, voltage pattern, timed stimulation pattern, and cyclic stimulation pattern), physician-controlled upper and lower limits (physician-adjustable range), and patient-controlled upper and lower limits (patient-independently adjustable range).

In a specific application scenario, the stimulation parameters of the stimulator may be adjusted in a current mode or a voltage mode.

The programming device may be a physician programming device (i.e., a programming device used by a physician) or a patient programming device (i.e., a programming device used by a patient). The doctor program control device may be, for example, an intelligent terminal device such as a tablet computer, a notebook computer, a desktop computer, and a mobile phone loaded with program control software. The patient program control device may be, for example, an intelligent terminal device such as a tablet computer, a laptop computer, a desktop computer, or a mobile phone, which is loaded with program control software, or may be another electronic device with a program control function (for example, a charger with a program control function, or a data acquisition device).

The embodiment of the application does not limit data interaction between the doctor program control equipment and the stimulator, and when the doctor performs remote program control, the doctor program control equipment can perform data interaction with the stimulator through the server and the patient program control equipment. When the doctor takes off-line and performs program control face to face with the patient, the doctor program control equipment can perform data interaction with the stimulator through the patient program control equipment, and the doctor program control equipment can also perform data interaction with the stimulator directly.

In some alternative embodiments, the patient-programmed device may include a master (in communication with the server) and a slave (in communication with the stimulator), with the master and slave being communicatively coupled. The doctor program control equipment can perform data interaction with the server through a 3G/4G/5G network, the server can perform data interaction with the host through the 3G/4G/5G network, the host can perform data interaction with the submachine through a Bluetooth protocol/WIFI protocol/USB protocol, the submachine can perform data interaction with the stimulator through a 401MHz-406MHz working frequency band/2.4 GHz-2.48GHz working frequency band, and the doctor program control equipment can perform data interaction with the stimulator directly through the 401MHz-406MHz working frequency band/2.4 GHz-2.48GHz working frequency band.

Except for the application field of the implantable device, the embodiment of the application can also be applied to the technical field of other medical devices or even non-medical devices, the embodiment of the application is not limited to this, and the application can be applied to occasions related to emergency program control, and the command sent by the doctor program control equipment to the stimulator can be not limited to the program control command.

(System embodiment)

Referring to fig. 1, fig. 1 shows a block diagram of a medical system provided in an embodiment of the present application.

An embodiment of the present application provides a medical system, including:

a stimulator 10 for implanting in a patient, sensing electrophysiological activity of the patient for electrophysiological signals, and delivering electrical stimulation to in vivo tissue of the patient;

the emergency call terminal 20 is used for receiving an emergency call operation to generate an active program control request;

an emergency programming device 30.

In some alternative embodiments, the emergency call terminal 20 and the emergency programming device 30 are integrated. At this time, the emergency call terminal 20 and the emergency programming device 30 are both disposed outside the patient.

In some alternative embodiments, the emergency call terminal 20 is provided with one or more of a call button, a rotary switch, a slide switch, a microphone assembly, and a camera assembly;

the rotary switch is provided with a calling gear;

the sliding switch is provided with a calling gear;

the camera assembly is provided with a camera and an image recognition chip.

Therefore, the emergency call terminal 20 may take various forms, such as a call button, a rotary switch, a slide switch, a microphone assembly, a camera assembly, etc., so that the patient can select a suitable emergency call terminal 20 according to performance requirements and cost requirements in practical applications, and the emergency call terminal has strong flexibility and wide application range.

The emergency call operation received by the call button may be, for example, an operation of pressing the call button.

The rotary switch may be provided with a call gear position and a close gear position, for example. The emergency call operation received by the rotary switch may be, for example, an operation of rotating the rotary switch to a call position.

The slide switch may be provided with a call gear position and a close gear position, for example. The emergency call operation received by the slide switch may be, for example, an operation of sliding the slide switch to a call position.

The microphone assembly may include, for example, a microphone and a voice recognition chip, which are communicatively coupled. The microphone is used for collecting voice information in real time and outputting the voice information to the voice recognition chip, the voice recognition chip can store a voice recognition model, voice recognition is carried out on the received voice information through the voice recognition model to obtain a voice recognition result, the voice recognition result can be classified into emergency call voice and meaningless voice, when the voice recognition result is the emergency call voice, it is judged that an emergency call operation is received, and the emergency call terminal 20 generates an active program control request.

The camera assembly may include, for example, a camera and an image recognition chip, which are communicatively coupled. The camera is used for acquiring image information in real time and outputting the image information to the image recognition chip, the image recognition chip can store an image recognition model, for example, the image recognition model is used for carrying out image recognition on the received image information to obtain an image recognition result, the image recognition result can be classified into an emergency call image and a nonsense image, for example, when the image recognition result is the emergency call image, it is judged that an emergency call operation is received, and the emergency call terminal 20 generates an active program control request.

In other alternative embodiments, the emergency programming device 30 is integrated with the stimulator 10. At this time, the emergency programming device 30 and the stimulator 10 are both disposed in the patient.

In some alternative embodiments, the person triggering the emergency call operation is either the patient (himself) or a care-giver. That is, the emergency call operation may be triggered by the patient himself or by his care provider.

In some alternative embodiments, the stimulator 10 may include:

a pulse generator 11;

an electrode lead 12, the electrode lead 12 for sensing electrophysiological activity of a patient and delivering electrical stimulation.

In the embodiment of the present application, the stimulator 10 may further include an extension lead 13, and the pulse generator 11, the electrode lead 12, and the extension lead 13 constitute the stimulator 10. When both the pulse generator 11 and the electrode lead 12 are implanted in the patient's cranium, the stimulator 10 may also not include the extension lead 13, but only the pulse generator 11 and the electrode lead 12.

In the embodiment of the present application, the pulse generator 11 is in communication connection with the electrode lead 12, and the pulse generator and the electrode lead may communicate directly with each other, or may implement data interaction through the extension lead 13.

In the present embodiment, the electrode lead 12 may be implanted in the cranium or other locations in the body of the patient. The number of electrode leads 12 may be, for example, 1, 2, 3, 4, 5, 6, etc. The number of electrode contacts per electrode lead 12 may be, for example, 4, 6, 8, 9, 10, 12, 15, 18, etc. When a patient has a plurality of electrode leads 12 implanted in the brain, the plurality of electrode leads 12 may be implanted in the same hemisphere of the brain, or may be implanted in two hemispheres of the brain, respectively.

In embodiments of the present application, the electrode leads 12 may be used to sense electrophysiological activity of a single cell and/or multiple cells to derive an electrophysiological signal and/or local field potential of the single cell. Local Field Potential (LFP) is a special class of electrophysiological signals. In a living organism, dendritic synaptic activity in a volume of biological tissue induces a current flow that, when flowing through an extracellular space with a certain impedance, creates a certain voltage distribution, and the local voltage value recorded at a certain point is called the local field potential.

Therefore, the electrical stimulation treatment directly electrically stimulates nerve targets (such as tissues such as nucleus accumbens, inner capsule forelimb, caudate nucleus, putamen and the like, nucleus pulposus, fiber bundles and the like), so that the disease condition of the diseases can be effectively controlled, the symptoms of the patient can be relieved, and the pain of the patient can be relieved.

In a specific application scenario, the electrode lead 12 is implanted in the cranium of a patient, and the electrode contact of the electrode lead 12 has the functions of sensing electrophysiological activity and delivering electrical stimulation; the pulse generator 11 can sense the local field potential of the brain of the patient by using the electrode lead 12, and when the patient is about to suffer from a disease or the disease is not controlled, an accurate and intermittent stimulation signal is timely sent to the brain of the patient in an intelligent and automatic mode.

In some optional embodiments, the medical system may further comprise:

a plurality of physician-programmed devices 40, each of the physician-programmed devices 40 for establishing a programmed connection with the stimulator 10 for configuring stimulation parameters of the stimulator 10.

Each of the physician programmable devices 40 may also receive a range configuration operation of a corresponding physician, configuring an adaptively adjustable numerical range corresponding to each stimulation parameter of the stimulator 10; the stimulator 10 is configured to perform adaptive adjustment in an adaptively adjustable numerical range corresponding to each stimulation parameter, so as to implement closed-loop control of the stimulation parameters. The closed-loop control process comprises the following steps: sensing in real time electrophysiological activity of a patient to obtain an electrophysiological signal; acquiring a state classification result corresponding to the electrophysiological signal; performing self-adaptive adjustment on the stimulation parameters based on the state classification result; the adjustment of the stimulation parameters may have an effect on the patient's condition, resulting in a change in the electrophysiological activity sensed at the next moment in time to obtain different electrophysiological signals.

Therefore, a doctor can configure a numerical range allowing the stimulator to adaptively adjust the stimulation parameters, and the safety of the electrical stimulation treatment is guaranteed. Doctors can set different numerical ranges for patients according to the severity of the illness state of different patients, and the safety and the treatment effect are both considered.

The physician program control device 40 is not limited in this embodiment, and may include one or more of a tablet computer, a laptop computer, a desktop computer, a mobile phone, a smart wearable device, and a console or a workstation, for example.

The manner in which the physician-programmed device 40 is utilized to receive the range configuration operation is not limited in this application. The operations are divided according to input modes, and may include, for example, a text input operation, a voice input operation, a video input operation, a key operation, a mouse operation, a keyboard operation, an intelligent stylus operation, and the like.

In the embodiment of the present application, the emergency program control device 30 may be configured to implement the steps of the emergency program control method, which will be described below first and then the emergency program control device 30.

(method embodiment)

Referring to fig. 2, fig. 2 shows a schematic flow chart of an emergency program control method provided in the embodiment of the present application.

The embodiment of the application also provides an emergency program control method, which comprises the following steps:

step S101: sensing the electrophysiological activity of a patient by utilizing a stimulator implanted in the corresponding patient to obtain electrophysiological signals of the patient when an active programming request sent by an emergency call terminal is received;

step S102: acquiring a state classification result corresponding to the patient based on the electrophysiological signal of the patient;

step S103: when the state classification result corresponding to the patient is used for indicating that the patient's condition is not controlled, forwarding the active programming request to a plurality of physician program-controlled devices so as to enable a target physician program-controlled device to establish a program-controlled connection with the stimulator, wherein the target physician program-controlled device is one of the plurality of physician program-controlled devices;

step S104: receiving a program control operation input by a target doctor by using the target doctor program control equipment to generate a corresponding program control command and sending the program control command to the stimulator so that the stimulator delivers the electrical stimulation corresponding to the program control command to the internal tissues of the patient.

Therefore, the real-time state of the patient is acquired according to the active program control request sent by the emergency call terminal, and the active program control request is forwarded to establish program control connection only when the condition of the patient is not controlled, so that the possibility of misusing the emergency program control function caused by mistakenly triggering the emergency call operation is reduced.

Specifically, when the emergency program control device receives an active program control request sent by an emergency call terminal, the emergency program control device does not forward the request at the first time, but firstly senses and obtains an electrophysiological signal by using a stimulator, the obtained electrophysiological signal can be used for classifying the real-time state of a patient to obtain a state classification result, and the state classification result is used for indicating whether the state of an illness of the patient is controlled; when the illness state of the patient is not controlled, the emergency program control equipment forwards the active program control request to a plurality of doctor program control equipment at the same time so as to enable one of the doctor program control equipment to establish program control connection with the stimulator; and then receiving the program control operation input by the target doctor by using the program control equipment of the target doctor, generating a corresponding program control command and sending the program control command to the stimulator, so that the stimulator is used for delivering the electrical stimulation corresponding to the program control command to the internal tissues of the patient. The programming operation may be, for example, an operation of configuring stimulation parameters of a stimulator, and the programming instructions may be, for example, used to configure the stimulation parameters of the stimulator.

Although the emergency program-controlled device in the prior art can acquire the health monitoring data of the patient and the corresponding type of call for help, the function is only to control the alarm device to give an alarm to expand the influence and advance the surrounding personnel to rescue the patient, and not to serve as a judgment condition for establishing the program-controlled connection. In other words, for the emergency programming device, a programming connection must be established as long as a triggering operation is received.

When the emergency program control device receives an active program control request sent by an emergency program control terminal, a judgment step is set for judging whether the active program control request is forwarded or not, specifically, electrophysiological activities of a patient are sensed in real time to obtain real-time electrophysiological signals, the state classification results of the patient are obtained by using the electrophysiological signals obtained in real time, and the active program control request is forwarded only when the state of an illness of the patient is not controlled (for example, the patient is in a state of being about to suffer from illness, suffering from illness or having life risks), so that program control connection between the target doctor program control device and a stimulator is established, stimulation parameters of the stimulator are configured by using the target doctor program control device, and timely and accurate electrical stimulation treatment is provided for the patient by using the stimulator.

When the state of illness of the patient is controlled (for example, the patient is in a state of no illness or normal health condition), even if the emergency program control equipment receives the active program control request of the emergency call terminal, the active program control request is not forwarded.

Therefore, the emergency program control equipment in the application is adopted to carry out targeted transfer on the active program control request (based on the real-time state of the patient), the possibility of misusing the emergency program control function caused by mistakenly triggering the emergency call operation of the emergency call terminal can be reduced, the emergency program control function is prevented from being occupied by the mistaken operation, and limited medical resources can serve the patient who really has the need or has the most urgent and urgent need.

In the embodiment of the present application, the electrophysiological signals may include one or more of electroencephalogram physiological signals, electromyography physiological signals, ocular electrophysiological signals, and electrocardiograph physiological signals, for example.

In the embodiment of the present application, the status classification result corresponding to the electrophysiological signal is used to indicate whether the condition of the patient is controlled, and specifically, the status classification result can be divided into two categories, i.e., the condition of the patient is controlled, and the condition of the patient is not controlled.

The number of the "multiple physician program controlled devices" is not limited in the embodiments of the present application, and may be, for example, 2, 3, 5, 8, 10, 20, 100, 1000, etc.

The application does not limit the manner of receiving the program control operation, the confirmation operation and the objection operation by using the program control equipment of each doctor. The operations are divided according to input modes, and may include, for example, a text input operation, a voice input operation, a video input operation, a key operation, a mouse operation, a keyboard operation, an intelligent stylus operation, and the like.

In an embodiment of the present application, the generated programming instructions are indicative of stimulation parameters of the stimulator.

As one example, the programmed instructions are used to instruct the stimulator of stimulation parameters as follows: the electrode contact identifications for delivering electrical stimulation are # 2 and # 3, the voltage amplitude of the stimulation pulse signal is 4.9V, the pulse width is 60 mus, and the frequency is 130Hz.

In some optional embodiments, the obtaining the corresponding state classification result of the patient based on the electrophysiological signal of the patient (i.e., step S102) may include:

inputting the electrophysiological signals of the patient into a state classification model to obtain a state classification result corresponding to the patient, wherein the state classification result corresponding to the patient is used for indicating whether the state of the patient is controlled.

The training process of the state classification model may include, for example:

acquiring a first training set, wherein the first training set comprises a plurality of first training data, each first training data comprises electrophysiological signals of a sample patient and label data of a state classification result corresponding to the sample patient, and the state classification result corresponding to the sample patient is used for indicating whether the state of an illness of the sample patient is controlled;

for each first training data in the first training set, performing the following:

inputting electrophysiological signals of the sample patient in the first training data into a preset first deep learning model to obtain prediction data of a state classification result corresponding to the sample patient;

updating model parameters of the first deep learning model based on the prediction data and the labeling data of the state classification result corresponding to the sample patient;

detecting whether a preset first training end condition is met; if yes, taking the trained first deep learning model as the state classification model; and if not, continuing to train the first deep learning model by utilizing the next training data.

Therefore, through design, a proper amount of neuron calculation nodes and a multilayer operation hierarchical structure are established, a proper input layer and a proper output layer are selected, a preset first deep learning model can be obtained, through learning and tuning of the first deep learning model, a function relation from input to output is established, although the function relation between input and output cannot be found 100%, the function relation can be close to a real association relation as far as possible, and the state classification model obtained through training can obtain corresponding output data based on the input data, and is wide in application range, high in calculation result accuracy and high in reliability.

In some alternative embodiments, the state classification model may be obtained by training in the embodiments of the present application, and in other alternative embodiments, the state classification model trained in advance may be used in the present application.

In some alternative embodiments, for example, historical data may be data mined to obtain electrophysiological signals for sample patients in the first training set. That is, these sample patients may be real patients. Alternatively, the electrophysiological signals of the sample patient can be automatically generated using a generating network of GAN models.

The GAN model is a Generative adaptive Network (generic adaptive Network) that consists of a Generative Network and a discriminant Network. The generation network takes random samples from the latent space (latency) as input, and its output needs to mimic the real samples in the training set as much as possible. The input of the discrimination network is the real sample or the output of the generation network, and the purpose is to distinguish the output of the generation network from the real sample as much as possible. The generation network should deceive the discrimination network as much as possible. The two networks resist each other and continuously adjust parameters, and the final purpose is to make the judgment network unable to judge whether the output result of the generated network is real or not. The GAN model can be used for generating electrophysiological signals of a plurality of sample patients, and is used for the training process of the state classification model, so that the data volume of original data acquisition can be effectively reduced, and the data acquisition and labeling cost is greatly reduced.

The method for acquiring the annotation data is not limited in the present application, and for example, a manual annotation method, an automatic annotation method, or a semi-automatic annotation method may be adopted. When the sample patient is a real patient, the real data can be obtained from the historical data as the labeling data in a keyword extraction mode.

The training process of the state classification model is not limited in the present application, and may be, for example, the above-mentioned supervised learning training mode, or may be a semi-supervised learning training mode, or may be an unsupervised learning training mode.

The preset first training end condition is not limited in the present application, and may be, for example, that the training frequency reaches a preset number (the preset number is, for example, 1, 3, 10, 100, 1000, 10000, etc.), or may be that the training data in the first training set all complete one or more times of training, or may be that the total loss value obtained by this training is not greater than the preset loss value.

Referring to fig. 3, fig. 3 is a schematic flowchart illustrating a process for generating a program control command according to an embodiment of the present application.

In some optional embodiments, the process of generating the program-controlled instruction in step S104 includes:

In the prior art, after the target doctor program control device is connected with the stimulator in a program control manner, the target doctor usually only uses the target doctor program control device to program the stimulator, and other doctors are not involved, so that the function similar to consultation cannot be provided. However, when the patient's condition is complex or even life-threatening, a single physician may not have sufficient ability to provide an optimal solution in a short period of time.

Therefore, although only the target doctor program-controlled device establishes the program-controlled connection with the stimulator, the first parameter configuration information corresponding to the program-controlled operation of the target doctor can be synchronously transmitted to other doctor program-controlled devices, so that other doctors can check whether the stimulation parameters configured by the target doctor are accurate and reasonable or not, and a function similar to voting is provided for other doctors.

if other doctors feel that the stimulation parameters configured by the target doctor are not reasonable, the other doctors can input objection operation through the corresponding doctor program control equipment to objectify the stimulation parameters configured by the target doctor, in other words, the objection operation of the program control equipment of the target doctor is objected.

Within a preset time length, as long as enough votes of other doctors are confirmed or only few votes of other doctors are proposed to make an objection, the program control operation of the target doctor can be considered to have higher reliability, and then a corresponding program control instruction can be generated based on the program control operation of the target doctor; however, if the number of tickets to be confirmed is too small or the number of tickets to be objected is too large, the reliability of the program control operation of the target doctor can be considered to be undetermined, and the corresponding program control instruction cannot be generated directly based on the program control operation of the target doctor.

The voting mechanism is introduced into the program control process of the target doctor for the patient, the opinions of other doctors are referred, the fact that a single target doctor makes a decision independently is avoided, program control operation is reasonable and reliable, more accurate electrical stimulation treatment can be provided for the patient, and doctor-patient disputes are reduced.

The preset time period is not limited in the embodiment of the present application, and may be, for example, 30 seconds, 1 minute, 2 minutes, 5 minutes, 10 minutes, or the like.

In the embodiment of the present application, the first preset number and the second preset number are not limited, the first preset number may be, for example, 1, 2, 3, 5, 10, and the like, and the second preset number may be, for example, 1, 2, 3, 5, 10, and the like.

With continued reference to fig. 3, in some alternative embodiments, the process of generating the program-controlled instruction in step S104 further includes:

and when the first similarity is not smaller than a preset similarity threshold value, generating a program control command corresponding to the program control operation by using the program control equipment of the target doctor.

Therefore, if the number of tickets to be confirmed is too small or the number of tickets for which an objection is proposed is too large, the reliability of the program control operation of the target doctor can be considered to be pending, and the reliability of the program control operation of the target doctor can be automatically determined without generating a corresponding program control command directly based on the program control operation of the target doctor.

Specifically, firstly, a parameter configuration model is utilized to intelligently obtain prediction parameter configuration information corresponding to the real-time electrophysiological signals of the patient, the trained parameter configuration model generally has higher accuracy, and the reliability of the prediction parameter configuration information is relatively guaranteed; then similarity calculation is carried out on the first parameter configuration information and the predicted parameter configuration information predicted by the parameter configuration model so as to obtain a first similarity between the first parameter configuration information and the predicted parameter configuration information; and comparing the first similarity with a preset similarity threshold, wherein when the first similarity is greater than or equal to the preset similarity threshold, the first parameter configuration information corresponding to the program control operation of the target doctor has higher similarity with the predicted parameter configuration information predicted by the parameter configuration model, the program control operation of the target doctor can be considered to be reliable, and then a corresponding program control instruction can be generated based on the program control operation of the target doctor.

The method has the advantages that the parameter configuration model is used for providing prediction parameter configuration information, the mode of combining intelligence (parameter configuration model) and manual work (other doctors) is adopted, the sequence is divided, the reliability of program control operation of the target doctor is judged, the judgment mode can give consideration to high accuracy and efficiency, and the method is suitable for the actual condition that the condition of a patient is complicated and changeable. On one hand, in the first stage, the reliability of the program control operation of the target doctor is manually judged, and when the program control operation of the target doctor is supported by enough manual votes from other doctors, the program control operation of the target doctor can be considered to be reliable; on the other hand, when the program control operation of the target doctor is not supported by enough manual voting, the program control operation is not directly judged to be unreliable, but the judgment process of the second stage is entered, the reliability of the program control operation of the target doctor is intelligently judged, namely, the predicted parameter configuration information predicted by the parameter configuration model and the first parameter configuration information corresponding to the program control operation are used for carrying out similarity calculation, and then whether the program control operation is reliable or not is judged according to the magnitude relation between the first similarity and the preset similarity threshold. Therefore, the intelligent judgment system has the advantages of high efficiency of intelligent judgment and wide application range of manual judgment.

In this embodiment of the present application, the first parameter configuration information, the second parameter configuration information, and the predicted parameter configuration information are all parameter configuration information, and prefixes of "first", "second", and "prediction" are used to distinguish different parameter configuration information. The parameter configuration information is used to indicate parameter values of stimulation parameters of the stimulator.

The preset similarity threshold is not limited in the embodiments of the present application, and may be, for example, 80%, 85%, 90%, 95%, 98%, 99%, or the like.

In a specific application scenario, the first parameter configuration information is "the voltage amplitude of the stimulation pulse signal is 4.9V, the pulse width is 60 μ s, and the frequency is 130Hz", and the predicted parameter configuration information is "the voltage amplitude of the stimulation pulse signal is 5V, the pulse width is 60 μ s, and the frequency is 120Hz".

The similarity calculation method in the embodiment of the present application is not limited, and for example, the similarity calculation method provided in the prior art may be used. As an example, a similarity calculation may be performed on the first parameter configuration information and the predicted parameter configuration information by using a pre-trained similarity model to obtain a similarity between the first parameter configuration information and the predicted parameter configuration information.

Wherein the training process of the parameter configuration model comprises the following steps:

acquiring a second training set, wherein the second training set comprises a plurality of second training data, and each second training data comprises an electrophysiological signal of a sample patient and label data of corresponding parameter configuration information;

for each second training data in the second training set, performing the following:

inputting electrophysiological signals of the sample patient in the second training data into a preset second deep learning model to obtain prediction data of corresponding parameter configuration information;

updating model parameters of the second deep learning model based on the prediction data and the labeling data of the corresponding parameter configuration information;

detecting whether a preset second training end condition is met; if yes, taking the trained second deep learning model as the parameter configuration model; and if not, continuing to train the second deep learning model by utilizing the next second training data.

Therefore, through design, a proper amount of neuron calculation nodes and a multilayer operation hierarchical structure are established, a proper input layer and a proper output layer are selected, a preset second deep learning model can be obtained, through learning and tuning of the second deep learning model, a function relation from input to output is established, although the function relation between input and output cannot be found 100%, the function relation can be close to a real association relation as far as possible, the parameter configuration model obtained through training can obtain corresponding parameter configuration information based on electrophysiological signals, and the method is wide in application range, high in accuracy of calculation results and high in reliability.

In some optional implementations, the parameter configuration model may be obtained by training in the embodiment of the present application, and in other optional implementations, a parameter configuration model trained in advance may be used in the present application.

In some alternative embodiments, for example, historical data may be data mined to obtain electrophysiological signals of sample patients in the second training set, and so on.

The present application does not limit the training process of the parameter configuration model, and for example, the above-mentioned supervised learning training mode may be adopted, or a semi-supervised learning training mode may be adopted, or an unsupervised learning training mode may be adopted.

The preset second training end condition is not limited in the present application, and may be, for example, that the training frequency reaches a preset frequency (the preset frequency is, for example, 1 time, 3 times, 10 times, 100 times, 1000 times, 10000 times, etc.), or that the second training data in the second training set all complete one or more times of training, or that the total loss value obtained by the current training is not greater than the preset loss value.

With continued reference to fig. 3, in some alternative embodiments, the process of generating the program control command in step S104 further includes:

when the first similarity is smaller than the preset similarity threshold, prompting other corresponding doctors to input second parameter configuration information by using other doctor program control equipment which receives objection operation to obtain one or more second parameter configuration information;

and when the maximum value of the second similarity is not smaller than the preset similarity threshold, generating a program control instruction corresponding to second parameter configuration information corresponding to the maximum value of the second similarity by using the program control equipment of the target doctor.

Therefore, in the first stage, other doctors confirm the program control operation of the target doctor less or provide more disagreements, so that the reliability of the program control operation is intelligently judged in the second stage, the first similarity between the first parameter configuration information of the target doctor and the predicted parameter configuration information is found to be smaller than the preset similarity threshold in the second stage, and the reliability of the program control operation of the target doctor cannot be confirmed through two-stage judgment, so that more support needs to be provided by other doctors.

At this time, other doctors who need to make an objection give their professional advice, that is, provide their approved second parameter configuration information. Next, in order to improve the efficiency of the program control process and ensure that the patient can be treated in time, second parameter configuration information of each strange doctor does not need to be pushed to each other, but the predicted parameter configuration information predicted by the parameter configuration model is continuously used as a reference, a second similarity between each second parameter configuration information and the predicted parameter configuration information is calculated, when the maximum value of the second similarity reaches the standard (that is, is not less than a preset similarity threshold), a program control instruction is generated based on the second parameter configuration information corresponding to the maximum value of the second similarity, and the generated program control instruction is used for configuring stimulation parameters of a stimulator and performing electrical stimulation treatment on the patient.

This has the advantage that when the reliability of the target physician's programming operation cannot be confirmed, other physicians provide parameter configuration information, but the other physician programming devices do not need to establish a programming connection with the stimulator, and continue to transmit programming commands by directly using the connected target physician programming device, except that the transmitted programming commands correspond to the second parameter configuration information provided by the other physicians.

On one hand, the second parameter configuration information with higher reliability provided by other doctors can be adopted, and the electrical stimulation treatment effect on the patient is improved; on the other hand, the time for establishing program-controlled connection between other doctor program-controlled equipment and the stimulator is saved, the treatment efficiency is improved, the pain of the patient is relieved quickly, and the life safety of the patient is guaranteed.

In some optional embodiments, the process of acquiring the patient corresponding to the emergency call terminal in step S101 includes:

Therefore, the active program control request sent by the emergency call terminal can carry the identification information of the patient and/or the identification information of the stimulator, so that the corresponding patient can be determined. The emergency call terminal may bind one or more patients to provide emergency call functionality for the one or more patients.

When a patient is bound, each active programming request sent carries the (fixed) identification information corresponding to that patient. The identification information corresponding to the patient may include identification information of the patient and/or identification information of a stimulator implanted in the patient.

When a plurality of patients are bound, the patients currently in need of emergency programming need to be manually determined when the active programming request is sent, for example, a manual interaction operation may be received by using an emergency call terminal to select one of the patients, and the interaction operation may be an operation of inputting a patient identifier, manually selecting a patient from a preset patient list, identifying a patient, and the like. The patient may be identified by, for example, identification card recognition, fingerprint recognition, face recognition, vein recognition, voice recognition, iris recognition, retina recognition, etc. Vein recognition may include, for example, palm vein recognition and/or finger vein recognition. After the patient with the current emergency program control requirement is determined, the active program control request generated by the emergency call terminal carries identification information corresponding to the patient (namely, the patient with the current emergency program control requirement).

In the embodiment of the present application, the identification information may be represented by one or more of chinese, letters, numbers, symbols, and figures, for example.

As an example, the identification information of patient a is "a001" and the identification information of stimulator B is "SN6666#".

In some optional embodiments, the method further comprises:

Therefore, after the target doctor program-controlled equipment establishes program-controlled connection with the stimulator, the target doctor is indicated to receive the task of emergency treatment of the patient, and the progress is informed to other doctors, so that the other doctors are prevented from still being in a state of asymmetric information. Otherwise, other doctors can only receive the distress signal of the active program control request, do not know whether the patient is treated or not, and can only judge that the emergency situation is eliminated by no longer receiving the distress signal, which may cause great psychological burden to the doctors and influence the enthusiasm of the doctors for participating in emergency program control.

In some optional embodiments, the method further comprises:

Therefore, only one doctor program control device is connected with the stimulator in a program control mode at the same time, only one doctor can perform program control on the patient at the same time (no matter off-line program control or remote program control), and the mutual interference of program control commands sent by the plurality of doctor program control devices, the treatment effect is prevented from being influenced, and even the life safety of the patient is prevented from being damaged.

In some optional embodiments, the method further comprises:

Therefore, when the target doctor performs program control, parameter configuration information of the patient in the past program control process can be provided as reference to assist the target doctor to perform program control operation, the target doctor can conveniently know the acceptance degree and tolerance degree of the patient to various stimulation parameters of electrical stimulation treatment, and the program control efficiency of the target doctor is improved.

In the present embodiment, N is not limited, and may be, for example, 2, 3, 5, 8, 10, 20, 50, or the like.

In some optional embodiments, the method further comprises:

sending the electrophysiological signals, the state classification result corresponding to the patient and the parameter configuration information corresponding to the program control instruction to a preset storage position; and/or the presence of a gas in the gas,

acquiring video information of the patient by using a camera and sending the video information to the preset storage position; and/or the presence of a gas in the gas,

Therefore, the electrophysiological signals acquired at this time, the corresponding state classification results thereof and the parameter configuration information corresponding to the program control instruction at this time are stored, and can be used for the subsequent data processing process; the video information and/or the voice information of the patient are/is stored, so that the treatment process can be traced intuitively and conveniently; the emergency program control equipment, the third-party platform equipment and the distribution robot thereof are utilized to provide the on-line medicine purchasing function based on the positioning information, so that the patient can quickly acquire the medicine corresponding to the disease of the patient, and the life safety of the patient is further guaranteed.

In this embodiment of the application, the preset storage location may be, for example, a local device or a cloud server.

The third party platform may be, for example, a public aid platform or a platform that provides on-line medication purchasing functionality. The third party platform device refers to a device corresponding to the third party platform, such as a computer or a server. The delivery robot may employ, for example, a drone or a wheeled (self-moving) robot. In addition, the third-party platform can also complete the distribution task of the medicine in a manual distribution mode.

In a specific application scenario, the emergency call terminal and the emergency program control device are integrated, a patient inputs an emergency call operation on the emergency program control device, and the emergency program control device sends an active program control request to a plurality of doctor program control devices, so that a plurality of online doctors are actively called. An on-line physician sees the call through his or her own physician programming device and agrees to program the patient, establishing a programmed connection between the physician programming device and the stimulator so that the physician can program the patient for emergency. Therefore, the urgent need of the patient is solved.

The Parkinson patient can also see all on-line emergency doctors on the emergency program control equipment, and actively reserve the emergency doctors to perform program control for the patient.

For the emergency program control process, the emergency program control equipment can automatically start the recording and video recording functions and record the real-time state (state classification result) of the patient and the parameter configuration information corresponding to the program control instruction in time.

For important medicine information used by a patient in an urgent need, platform equipment of an emergency rescue department or platform equipment of various on-line medicine purchasing platforms, such as a pharmacy C or a medicine purchasing platform D, can be butted, and medicines needed by the patient can be timely delivered to the hands of the patient.

(apparatus embodiment)

The application further provides an emergency program control device, and the specific implementation manner of the emergency program control device is consistent with the implementation manner and the achieved technical effect recorded in the method embodiment, and parts of the content are not described in detail.

The emergency programming device includes a processor configured to implement the steps of:

sensing the electrophysiological activity of a patient by utilizing a stimulator implanted in the corresponding patient to obtain electrophysiological signals of the patient when an active programming request sent by an emergency call terminal is received;

acquiring a state classification result corresponding to the patient based on the electrophysiological signal of the patient;

and within a preset time length, when the number of the received confirmation operations is not less than a first preset number or the number of the received objection operations is not more than a second preset number, generating a program control instruction corresponding to the program control operation by using the program control equipment of the target doctor.

the stimulator is limited in parallel so that it can be programmed with at most one physician programming device.

and sending the medicine information corresponding to the disease of the patient and the positioning information of the patient to third-party platform equipment so that a delivery robot corresponding to the third-party platform equipment delivers the medicine corresponding to the medicine information to the positioning information.

Referring to fig. 4, fig. 4 is a block diagram illustrating a structure of an emergency program control device according to an embodiment of the present disclosure.

The emergency programming device may include, for example, at least one memory 210, at least one processor 220, and a bus 230 connecting the different platform systems.

The memory 210 may include readable media in the form of volatile memory, such as Random Access Memory (RAM) 211 and/or cache memory 212, and may further include Read Only Memory (ROM) 213.

Wherein the memory 210 further stores a computer program that can be executed by the processor 220 such that the processor 220 implements the steps of any of the methods described above.

Memory 210 may also include a utility 214 having at least one program module 215, such program modules 215 including, but not limited to: an operating system, one or more application programs, other program modules, and program data, each of which, or some combination thereof, may comprise an implementation of a network environment.

Accordingly, the processor 220 can execute the computer programs described above, and can execute the utility 214.

The processor 220 may employ one or more Application Specific Integrated Circuits (ASICs), DSPs, programmable Logic Devices (PLDs), complex Programmable Logic Devices (CPLDs), field Programmable Gate Arrays (FPGAs), or other electronic components.

Bus 230 may be one or more of any of several types of bus structures including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, and a processor or local bus using any of a variety of bus architectures.

The emergency programming device may also communicate with one or more external devices 240, such as a keyboard, pointing device, bluetooth device, etc., one or more devices capable of interacting with the emergency programming device, and/or any device (e.g., router, modem, etc.) that enables the emergency programming device to communicate with one or more other computing devices. Such communication may be through input-output interface 250. Also, the emergency programming device may communicate with one or more networks (e.g., a Local Area Network (LAN), a Wide Area Network (WAN), and/or a public network, such as the internet) via network adapter 260. The network adapter 260 may communicate with other modules of the emergency programming device via the bus 230. It should be understood that although not shown, other hardware and/or software modules may be used in conjunction with the emergency programming device, including but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives, and data backup storage platforms, to name a few.

(media embodiment)

An embodiment of the present application further provides a computer-readable storage medium, where a computer program is stored, and when the computer program is executed by a processor, the steps of any one of the methods described above are implemented or the function of any one of the emergency program control devices is implemented, and a specific implementation manner of the computer program is consistent with the implementation manner and the achieved technical effect described in the method embodiment, and some contents are not described again.

Referring to fig. 5, fig. 5 shows a schematic structural diagram of a program product provided in an embodiment of the present application.

The program product is for implementing the steps of any of the methods described above. The program product may employ a portable compact disc read only memory (CD-ROM) and include program code, and may be run on a terminal device, such as a personal computer. However, the program product of the present invention is not limited thereto, and in the embodiments of the present application, the readable storage medium may be any tangible medium that can contain or store a program, which can be used by or in connection with an instruction execution system, apparatus, or device. The program product may employ any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the readable storage medium include: an electrical connection having one or more wires, a portable disk, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

A computer readable storage medium may include a propagated data signal with readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A readable storage medium may also be any readable medium that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a readable storage medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing. Program code for carrying out operations for aspects of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, C + + or the like and conventional procedural programming languages, such as the C language or similar programming languages. The program code may execute entirely on the user's computing device, partly on the user's device, as a stand-alone software package, partly on the user's computing device and partly on a remote computing device, or entirely on the remote computing device or server. In the case of a remote computing device, the remote computing device may be connected to the user computing device through any kind of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or may be connected to an external computing device (e.g., through the internet using an internet service provider).

While the present application is described in terms of various aspects, features, and advantages, it is to be understood that such aspects are merely illustrative of and not restrictive on the broad application, and that all changes and modifications that come within the spirit and scope of the appended claims are desired to be protected by the following claims.

Claims

1. An emergency programming device comprising a processor configured to implement the steps of:

when the state classification result corresponding to the patient is used for indicating that the condition of the patient is not controlled, forwarding the active programming request to a plurality of physician program control devices to enable a target physician program control device to establish program control connection with the stimulator, wherein the target physician program control device is one of the plurality of physician program control devices;

receiving, by the target physician programming device, a programming operation input by a target physician to generate a corresponding programming command and send the corresponding programming command to the stimulator, so that the stimulator delivers electrical stimulation corresponding to the programming command to the in-vivo tissue of the patient.

2. The emergency programming device of claim 1, wherein the processor is configured to generate the programming instructions by:

3. The emergency programming device of claim 2, wherein the processor is further configured to generate the programming instructions by:

4. The emergency programming device of claim 3, wherein the processor is further configured to generate the programming instructions by:

5. The emergency programming device of claim 1, wherein the process of obtaining the patient corresponding to the emergency call terminal comprises:

6. The emergency programming device of claim 1, wherein the processor is further configured to implement the steps of:

and after the target doctor program control equipment establishes program control connection with the stimulator, sending prompt information to other doctor program control equipment in the plurality of doctor program control equipment, wherein the prompt information is used for indicating that the active program control request has a doctor response.

7. The emergency programming device of claim 1, wherein the processor is further configured to implement the steps of:

8. The emergency programming device of claim 1, wherein the processor is further configured to implement the steps of:

sending the electrophysiological signals, the state classification result corresponding to the patient and the parameter configuration information corresponding to the program control instruction to a preset storage position; and/or the presence of a gas in the atmosphere,

acquiring voice information of the patient by using a microphone and sending the voice information to the preset storage position; and/or the presence of a gas in the gas,

9. A medical system, characterized in that the medical system comprises:

the emergency programming device of any of claims 1-8.

10. The medical system of claim 9, wherein the emergency call terminal and the emergency programming device are integrated; and/or the presence of a gas in the gas,

the rotary switch is provided with a calling gear;

the sliding switch is provided with a calling gear;

the camera assembly is provided with a camera and an image recognition chip.

11. The medical system of claim 9, wherein the emergency programming device and the stimulator are integrated.

12. The medical system of claim 9, wherein the person triggering the emergency call operation is any one of the patient or a care-giver.

13. The medical system of claim 9, wherein the disease of the patient comprises at least one of:

spasmodic disorders, depression, bipolar disorder, anxiety, post-traumatic stress disorder, obsessive-compulsive disorder, behavioral disorders, mood disorders, memory disorders, mental state disorders, tremors, parkinson's disease, huntington's disease, alzheimer's disease, addictive disorders and autism.

14. A computer-readable storage medium, characterized in that the computer-readable storage medium stores a computer program which, when executed by a processor, implements the functionality of the emergency programming device of any of claims 1-8.