CN115469047A - Counter-current chromatographic separation column without adapter - Google Patents
Counter-current chromatographic separation column without adapter Download PDFInfo
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- CN115469047A CN115469047A CN202211151395.6A CN202211151395A CN115469047A CN 115469047 A CN115469047 A CN 115469047A CN 202211151395 A CN202211151395 A CN 202211151395A CN 115469047 A CN115469047 A CN 115469047A
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- 238000013375 chromatographic separation Methods 0.000 title claims abstract description 11
- 238000004804 winding Methods 0.000 claims abstract description 50
- 238000000926 separation method Methods 0.000 claims abstract description 40
- 238000009434 installation Methods 0.000 claims abstract description 10
- 230000007704 transition Effects 0.000 claims description 65
- 238000004185 countercurrent chromatography Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 8
- 238000007599 discharging Methods 0.000 abstract description 3
- 238000005452 bending Methods 0.000 description 5
- 230000000149 penetrating effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000622 liquid--liquid extraction Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/42—Flow patterns using counter-current
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Abstract
The invention relates to the technical field of chromatographs, and particularly discloses a countercurrent chromatographic separation column without an adapter, which comprises a bobbin and a central guide plate, wherein an annular winding cavity is arranged in the bobbin, the middle part of the bobbin is provided with an installation groove, the central guide plate is arranged in the installation groove, and the central guide plate is provided with a feeding pipe inlet straight hole and a feeding pipe outlet straight hole; the winding drum is characterized in that a feeding pipe inlet guide groove and a feeding pipe outlet guide groove are formed in the top end face of the winding drum, one end of the feeding pipe inlet guide groove is communicated with the winding cavity, the other end of the feeding pipe inlet guide groove is communicated with the mounting groove, one end of the feeding pipe outlet guide groove is communicated with the winding cavity, and the other end of the feeding pipe outlet guide groove is communicated with the mounting groove. The invention has the advantages that the knotting of the two hook parts at the feeding end and the discharging end of the feeding pipe in the rotation process of the separation column can be prevented under the condition of not arranging the adapter, so that the feeding pipe can be smoothly led into the unwinding frame to be normally unwound.
Description
Technical Field
The invention relates to the technical field of chromatographs, in particular to a countercurrent chromatographic separation column without an adapter.
Background
The countercurrent chromatography is a continuous and efficient liquid-liquid distribution chromatography separation technology, a two-dimensional force field is generated through simultaneous revolution and rotation planetary motion, one of two phases is reserved as a stationary phase, and separation and extraction are realized in the high-speed rotation process.
As shown in fig. 1 and 2, the first countercurrent chromatography separation column structure in the prior art includes an integrated bobbin 31, a planetary rotating shaft 34 and an expansion member 35, wherein the center of the upper end of the bobbin 31 is connected with one end of an unwinding tube 32, and the other end of the unwinding tube 32 is connected with a central shaft 33. The upper end of the integrated bobbin 31 is provided with two adapters 36, when being installed, the threading operation of the separation column is completed firstly, specifically, two feeding pipes penetrate out of a threading hole in the central shaft 33, enter the integrated bobbin 31 through the unwinding pipe 32, and respectively penetrate through the lower ends of the two adapters 36 to complete connection; and a feeding pipe is wound on the integrated bobbin 31, so that the two ends of the feeding pipe penetrate out of the top of the integrated bobbin 31 and respectively penetrate through the upper ends of the two adapters 36 to complete connection. Then insert the lower extreme of integrative bobbin 31 with bloated piece 35 and planet pivot 34, later the instrument from the bloated tight hole site 38 of screwing up at integrative bobbin 31 top pass and utilize its tightening screw 37, bloated piece 35 of taking place axial displacement in the tightening process, wedge the hole between planet pivot 34 and integrative bobbin 31, make both connect through bloated tightly. In the detaching operation, it is necessary to loosen the screw 37 and then apply an axial force to the empty ejection insertion tool at the top of the integral bobbin 31 to eject the integral bobbin 1 from the expansion member 35, thereby completing the detaching operation.
The existing countercurrent chromatographic column structure has the following defects in use: firstly, the connection between the integrated bobbin 31 and the planetary rotating shaft 34 through wedging and expansion of the expansion piece 35 has poor reliability, if the integrated bobbin 31 and the planetary rotating shaft 34 are in long-term high-speed operation, the position between the expansion screwing hole 38 and the screw 37 is dislocated, so that the disassembly is difficult or even impossible, therefore, in practical use, the working speed is generally required to be reduced to below 2000r/min, and the separation capacity and the separation efficiency are relatively low; secondly, in above-mentioned threading operation, the conveying pipe penetrates when the lower extreme of adapter 36 accomplishes the connection, need tighten the hollow screw of this adapter 36 lower extreme, need to wear into this screw earlier because of the conveying pipe, tighten again, simultaneously because operating space is limited, hexagonal countersunk head screw in can't using, can only adopt outer hexagonal screw, this head that leads to this screw has more arch, the conveying pipe has longer part to be bent, the conveying pipe pressure of bending part has increased, and the internal diameter of conveying pipe only has 0.8mm, be in under the high pressure for a long time, the leakage appears more easily, and then lead to whole separation post to become invalid. Thirdly, in the structure, because the adapter 36 is arranged on the feeding pipe between the integrated winding drum 31 and the unwinding pipe 32, once the adapter 36 leaks the solvent, the solvent loss and pollution in the whole feeding pipe can be caused; fourthly, in the structure, because trace sample residues on the sealing interface of the adapter 36 are difficult to wash, the detection results of samples in other batches are easily interfered;
the countercurrent chromatographic separation column in the prior art has a second structure, and the patent numbers are as follows: 2021110888353 discloses a cantilever type countercurrent chromatograph without an adapter, and the second existing countercurrent chromatographic column structure has the following defects in use: firstly, the structure of the chromatographic separation column is the same as that of the traditional countercurrent chromatographic separation column, and the problem of difficult disassembly exists; secondly, the feeding pipe guide groove is lack of an arc transition section, so that the feeding pipe is easily bent excessively at the inlet and the outlet of the separation column to generate blockage; thirdly, the feed pipe is easy to directly contact at the step of the guide groove to generate abrasion because inclined hole guiding is lacked between the guide groove and the central threaded hole of the separation column; fourth, under the existing structure, the back is worn out from the unwinding frame to whole root conveying pipe, through the guide way direct introduction separation post entry, then export from the separation post again, directly draw back to in the unwinding frame through the guide way, because separation post central thread hole department lacks the deflector, conveying pipe feed end and discharge end can form two "crotch" parts of freely hanging in separation post central thread hole, when planet carrier and separation post high-speed rotatory, two "crotch" type conveying pipes can entangle each other along with rotary motion, and because this part pipeline winding takes place in separation post central thread hole, not in the unwinding pipe, unable normal unwinding, so two "crotch" type conveying pipes can twine more tightly, until damaged inefficacy.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a counter-flow chromatographic separation column without an adapter, which has a simple structure and can prevent a feeding pipe from winding in the unwinding process.
The purpose of the invention is realized by the following technical scheme: a countercurrent chromatographic separation column without an adapter comprises a bobbin and a central guide plate, wherein an annular winding cavity is arranged in the bobbin, an installation groove is formed in the middle of the bobbin, the central guide plate is arranged in the installation groove, and a feeding pipe inlet straight hole and a feeding pipe outlet straight hole are formed in the central guide plate; the winding drum is characterized in that a feeding pipe inlet guide groove and a feeding pipe outlet guide groove are formed in the top end face of the winding drum, one end of the feeding pipe inlet guide groove is communicated with the winding cavity, the other end of the feeding pipe inlet guide groove is communicated with the mounting groove, one end of the feeding pipe outlet guide groove is communicated with the winding cavity, and the other end of the feeding pipe outlet guide groove is communicated with the mounting groove.
Specifically, the feeding pipe inlet guide groove comprises a first arc section, a first transition section and a second transition section, the first transition section and the second transition section are located at two ends of the arc section, the second transition section is communicated with the winding cavity through a feeding pipe inlet, the second transition section is communicated with the mounting groove through a feeding pipe inlet inclined hole, and the first arc section is in arc transitional connection with the first transition section and the second transition section.
Specifically, the feeding pipe outlet guide groove comprises a second arc section and a third transition section, one end of the second arc section is communicated with the winding cavity through a feeding pipe outlet, the other end of the second arc section is in arc transition connection with the third transition section, and the third transition section is communicated with the mounting groove through a feeding pipe outlet inclined hole.
Specifically, the inner wall of the mounting groove is symmetrically provided with mounting tables, two ends of the central guide plate are fixed on the mounting tables, and the inclined inlet hole and the inclined outlet hole of the feeding pipe are respectively arranged on the two mounting tables.
Specifically, the inclined hole of the feeding pipe inlet and the inclined hole of the feeding pipe outlet are symmetrically and obliquely arranged.
Specifically, the bottoms of the feeding pipe inlet straight hole and the feeding pipe outlet straight hole are respectively provided with a guide groove, and the guide grooves of the feeding pipe inlet straight hole and the feeding pipe outlet straight hole are respectively arranged towards the feeding pipe inlet inclined hole and the feeding pipe outlet inclined hole in an inclined mode.
The middle part of the winding reel is provided with a central threaded hole, the central threaded hole is communicated with the mounting groove and further comprises a planet shaft, a clamping strip fixing bolt and a locking clamping strip, one end of the planet shaft is arranged in the central threaded hole, a threaded connecting hole is formed in the end face of the planet shaft, a counter bore is formed in the end face of the planet shaft, slots are symmetrically formed in the end face of the planet shaft, grooves are formed in the bottom of the mounting groove and the slots correspondingly, limit blocks are symmetrically arranged on the locking clamping strip, the middle part of the locking clamping strip is arranged in the counter bore, the limit blocks of the locking clamping strip are arranged in the grooves and the slots respectively, and the clamping strip fixing bolt penetrates through the locking clamping strip and the threaded connecting hole to be in threaded connection.
Specifically, the bottom of the central threaded hole is a stepped hole, the planet shaft is provided with a limiting step, and the limiting step is matched with the stepped hole for limiting.
Specifically, the inlet of the feeding pipe is positioned on the inner side of the winding cavity, and the outlet of the feeding pipe is positioned on the outer side of the winding cavity.
Specifically, the bottom of the mounting groove is provided with a finger groove.
The invention has the following advantages:
1. compared with the prior art, the anti-loosening clamping strip is installed in an expansion mode, so that the structure is more stable, the anti-loosening clamping strip and the bobbin are limited, the anti-loosening clamping strip and the planet shaft are connected together through the bolt, the structure can prevent the planet shaft and the bobbin from rotating relatively, and the disassembly is convenient.
2. According to the invention, the central guide plate is provided with the feeding pipe inlet straight hole and the feeding pipe outlet straight hole, and the feeding end and the discharging end of the feeding pipe respectively vertically penetrate through the feeding pipe inlet straight hole and the feeding pipe outlet straight hole, so that the feeding end and the discharging end of the feeding pipe positioned in the separation column can be ensured to be mutually isolated, and can be also ensured to be vertically led out from the central area of the separation column and can be led into the unwinding frame of the chromatograph in a vertically constrained state.
3. The invention penetrates the feeding pipe into the mounting groove from the straight hole of the feeding pipe inlet during threading, and then penetrates the inclined hole of the feeding pipe inlet from bottom to top, so that the feeding pipe positioned in the mounting groove between the straight hole of the feeding pipe inlet and the inclined hole of the feeding pipe inlet can form the shape of a hook, the inclined hole of the feeding pipe inlet is an inclined hole, the angle of the formed hook can be increased, the feeding pipe is prevented from being blocked due to small-angle bending, and meanwhile, the feeding pipe is enabled to be in arc transition at an angle of more than 90 degrees when entering the guiding groove of the feeding pipe inlet, so as to prevent blocking, compared with the prior art that a straight-in straight-out mode is adopted, the anti-blocking effect is better, similarly, when the feeding pipe penetrates out, the feeding pipe penetrates through the feeding pipe outlet inclined hole from top to bottom to enter the installation groove, then penetrates through the feeding pipe outlet straight hole from bottom to top, and a part of the feeding pipe between the feeding pipe outlet straight hole and the feeding pipe outlet inclined hole forms a large-angle hook, so that the feeding pipe is prevented from being blocked due to small-angle bending, and the feeding pipe is also enabled to be in arc transition at an angle larger than 90 degrees when entering the feeding pipe outlet inclined hole from the feeding pipe outlet guide groove, so that the blocking is prevented; by adopting the structure, the feed pipe can be bent by the large-angle circular arcs of the bending parts when penetrating in the bobbin, thereby preventing the bobbin from leaking under high pressure due to the fact that high pressure is generated locally.
4. The feeding pipe inlet guide groove is designed into a first arc section, a first transition section and a second transition section, wherein the first arc section is arc-shaped and is positioned at two ends of the first arc section, the first arc section is coaxial with the winding drum and is positioned at the outer side of the winding cavity, the first transition section is arranged along the radial direction of the winding drum and is in arc transition connection with the first arc section, the width of the arc transition connection part is increased, so that the feeding pipe can be bent in a large-angle arc shape and smoothly transited when penetrating out of an inclined hole of the feeding pipe inlet and entering the first transition section and the first arc section, blockage is prevented, similarly, the second transition section is in arc transition connection with the first arc section, the feeding pipe can be in arc transition when entering the second transition section from the first arc section and enters the winding cavity from the feeding pipe inlet, and the feeding pipe outlet guide groove also adopts a mode of arc transition of the second arc section and the third transition section, the feeding pipe is in smooth transition in a mode of arc transition, and blockage is prevented.
Drawings
FIG. 1 is a schematic cross-sectional view of a prior art countercurrent chromatography separation column;
FIG. 2 is a schematic top view of a prior art countercurrent chromatography separation column;
FIG. 3 is a schematic view of the overall structure of the separation column of the present invention;
FIG. 4 is a schematic cross-sectional view of a separation column according to the present invention;
FIG. 5 is a schematic view of a center guide plate structure according to the present invention;
FIG. 6 is a schematic view of an assembly structure of the anti-loosening clamping strip of the separation column of the present invention;
FIG. 7 is a schematic view of the bobbin of the present invention;
FIG. 8 is a schematic view of the planet axle configuration of the present invention;
FIG. 9 is a schematic structural view of a locking bar of the present invention;
in the figure: 1-bobbin, 2-center guide plate, 3-winding cavity, 4-mounting groove, 5-feeding pipe inlet straight hole, 6-feeding pipe outlet straight hole, 7-feeding pipe inlet guide groove, 8-feeding pipe outlet guide groove, 9-feeding pipe inlet, 10-feeding pipe inlet inclined hole, 11-feeding pipe outlet, 12-feeding pipe outlet inclined hole, 13-mounting table, 14-guide groove, 15-center threaded hole, 16-planet shaft, 17-clamping bar fixing bolt, 18-locking clamping bar, 19-threaded connecting hole, 20-counter bore, 21-slotting, 22-groove, 23-limiting block, 24-limiting step, 25-finger groove, 31-integrated bobbin, 32-unwinding pipe, 33-center shaft, 34-planet rotating shaft, 35-expansion piece, 36-adapter, 37-tightening screw, 38-expansion tightening hole position.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising a … …" does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.
The invention will be further described with reference to the accompanying drawings, but the scope of the invention is not limited to the following.
As shown in fig. 1-9, a countercurrent chromatography separation column without an adapter comprises a bobbin 1 and a central guide plate 2, wherein an annular winding cavity 3 is arranged in the bobbin 1, an installation groove 4 is arranged in the middle of the bobbin 1, the central guide plate 2 is arranged in the installation groove 4, and a feeding pipe inlet straight hole 5 and a feeding pipe outlet straight hole 6 are arranged on the central guide plate 2; the bobbin comprises a bobbin 1 and is characterized in that a feeding pipe inlet guide groove 7 and a feeding pipe outlet guide groove 8 are formed in the top end face of the bobbin 1, one end of the feeding pipe inlet guide groove 7 is communicated with a winding cavity 3, the other end of the feeding pipe inlet guide groove 7 is communicated with a mounting groove 4, one end of the feeding pipe outlet guide groove 8 is communicated with the winding cavity 3, and the other end of the feeding pipe outlet guide groove 8 is communicated with the mounting groove 4. In this embodiment, the separation column is integrally cylindrical, a circular winding cavity 3 is arranged inside the separation column for winding a feeding pipe, wherein a cylindrical shell outside the winding cavity 3 is of a detachable structure, two ends of a central guide plate 2 are fixed on a bobbin 1 through bolts during use, a feeding pipe inlet straight hole 5 and a feeding pipe outlet straight hole 6 are arranged on the central guide plate 2, one end of the feeding pipe penetrates through the feeding pipe inlet straight hole 5 and extends into a mounting groove 4 during threading, then the feeding pipe penetrates through a feeding pipe inlet inclined hole 10 from bottom to top, thus the feeding pipe between the feeding pipe inlet straight hole 5 and the feeding pipe inlet inclined hole 10 can form a hook shape, a special feeding pipe inlet inclined hole 10 is obliquely arranged, thus the angle of the hook shape can be increased, the feeding pipe is prevented from being bent at a small angle to be blocked, the feeding pipe penetrates through the feeding pipe inlet inclined hole 7 after penetrating through the feeding pipe inlet inclined hole 10, penetrates through the feeding pipe inlet guide groove 7 and penetrates through the feeding pipe outlet straight hole 6 from top to bottom, and penetrates through the feeding pipe outlet straight hole 12 from top to bottom, the feeding pipe outlet straight hole and the feeding pipe outlet straight hole 6, the feeding pipe outlet straight hole 12 and the feeding pipe outlet straight hole formed by the feeding pipe outlet straight hole from top to bottom, guarantee that the feed end and the discharge end of conveying pipe are all drawn forth perpendicularly from the separation post center to in the unwinding frame of chromatograph is introduced perpendicularly, just so can prevent that two crotch parts of conveying pipe feed end and discharge end from producing in the separation post rotation process and knoing, thereby guarantee that the conveying pipe is smooth-going to be introduced to normally unwinding in the unwinding frame.
Further, the feeding pipe inlet guide groove 7 comprises a first arc section 71, and a first transition section 72 and a second transition section 73 which are positioned at two ends of the first arc section 71, the second transition section 73 is communicated with the winding cavity 3 through a feeding pipe inlet 9, the first transition section 72 is communicated with the mounting groove 4 through a feeding pipe inlet inclined hole 10, and the first arc section 71 is in arc transition connection with the first transition section 72 and the second transition section 73. In this embodiment, the first arc section 71 is arc-shaped coaxial with the bobbin 1, the first transition section 72 is arranged along the radial direction and is connected with the first arc section 71 in an arc transition manner, the width of the arc transition connection is increased, so that the feeding pipe can be bent in a large-angle arc manner when penetrating through the inclined hole 10 of the feeding pipe inlet and entering the first transition section 72 and the first arc section 71, the feeding pipe is smoothly transited to prevent blockage, similarly, the second transition section 73 is connected with the arc transition of the first arc section 71, and when the feeding pipe enters the second transition section 73 from the first arc section 71, the feeding pipe can be transited in an arc manner and enters the winding cavity 3 from the feeding pipe inlet 9.
Further, the feeding pipe outlet guide groove 8 comprises a second circular arc section 81 and a third transition section 82, one end of the second circular arc section 81 is communicated with the winding cavity 3 through the feeding pipe outlet 11, the other end of the second circular arc section 81 is in circular arc transition connection with the third transition section 82, and the third transition section 82 is communicated with the mounting groove 4 through the feeding pipe outlet inclined hole 12. In the embodiment, the second arc section 81 is in an arc shape coaxial with the bobbin 1, the third transition section 82 is arranged along the radial direction and is in arc transition connection with the second arc section 81, and the width of the arc transition connection part is increased, so that the feeding pipe can be bent in an arc shape with a large angle when entering the third transition section 82 from the second arc section 81, and blockage is prevented; because the winding is seted up from the inboard in wire winding chamber 3 when the conveying pipe winding is in wire winding chamber 3, therefore, conveying pipe entry 9 corresponds the inboard that sets up at wire winding chamber 3, first circular arc section 71 sets up the outside at wire winding chamber 3, can give the bigger space of buckling of conveying pipe like this, but just so need come the transition through second changeover portion 73 and guide the conveying pipe from conveying pipe entry 9 to getting into wire winding chamber 3 in, after the conveying pipe winding is accomplished, the end correspondence at the conveying pipe is drawn from the outside in wire winding chamber 3, consequently, set up conveying pipe export 11 in the outside of wire winding chamber 3, the bigger space of buckling of conveying pipe is given in wire winding chamber 3 outside in same second circular arc section 81 setting, the one end of conveying pipe just can directly get into second circular arc section 81 through conveying pipe export 11 like this.
Further, the inner wall of the mounting groove 4 is symmetrically provided with mounting tables 13, two ends of the central guide plate 2 are fixed on the mounting tables 13, the feeding pipe inlet inclined hole 10 and the feeding pipe outlet inclined hole 12 are respectively arranged on the two mounting tables 13, and the feeding pipe inlet inclined hole 10 and the feeding pipe outlet inclined hole 12 are symmetrically and obliquely arranged. In this embodiment, the mounting table 13 is provided with the clamping groove, the two ends of the central guide plate 2 are arranged in the clamping groove and are fixedly connected through the bolt, so that the central guide plate 2 is stably connected when the separation column rotates at a high speed, the inclined inlet hole 10 and the inclined outlet hole 12 of the feeding pipe are symmetrically and obliquely arranged, and the feeding pipe can be bent at a larger angle in the mounting groove 4.
Furthermore, the bottoms of the feeding pipe inlet straight hole 5 and the feeding pipe outlet straight hole 6 are both provided with guide grooves 14, and the guide grooves 14 of the feeding pipe inlet straight hole 5 and the feeding pipe outlet straight hole 6 are respectively arranged towards the feeding pipe inlet inclined hole 10 and the feeding pipe outlet inclined hole 12 in an inclined manner. In the embodiment, the guide grooves 14 are arranged at the bottoms of the feeding pipe inlet straight hole 5 and the feeding pipe outlet straight hole 6, and the guide grooves 14 and the bottom surface of the central guide plate 2 form an included angle larger than 90 degrees, so that a larger adjusting space can be provided during bending, and the feeding pipe cannot be scratched.
Further, 1 middle part of bobbin be provided with central screw hole 15, central screw hole 15 and mounting groove 4 intercommunication still include planet axle 16, card strip fixing bolt 17 and locking card strip 18, the one end of planet axle 16 is arranged in central screw hole 15, be provided with threaded connection hole 19 on the terminal surface of planet axle 16, be provided with counter bore 20 on the terminal surface of planet axle 16, the symmetry is provided with fluting 21 on the terminal surface of planet axle 16, mounting groove 4 bottom corresponds with fluting 21 and is provided with recess 22, the symmetry is provided with stopper 23 on the locking card strip 18, the middle part of locking card strip 18 is arranged in counter bore 20, and in recess 22 and fluting 21 were arranged in to stopper 23 of locking card strip 18, card strip fixing bolt 17 passed locking card strip 18 and threaded connection hole 19 threaded connection, central screw hole 15 bottom be the shoulder hole, planet axle 16 is provided with spacing step 24, spacing step 24 and shoulder hole cooperation carry on spacingly. In this embodiment, one end of the planet shaft 16 is placed in the central threaded hole 15, the anti-loose clamping strip 18 is clamped in the counter bore 20 of the planet shaft 16, the limiting blocks 23 on two sides of the anti-loose clamping strip 18 are clamped in the corresponding grooves 22 and the corresponding slots 21, then the clamping strip fixing bolt 17 passes through the anti-loose clamping strip 18 and is in threaded connection with the threaded connection hole 19 of the planet shaft 16, so that the relative rotation of the bobbin 1 and the planet shaft 16 can be limited, the rotation of the planet shaft 16 can drive the bobbin 1 to rotate, then the limiting step 24 is arranged on the planet shaft 16, the axial direction of the planet shaft 16 can be limited by matching the limiting step 24 with the stepped hole and the anti-loose clamping strip 18, and the installation of the planet shaft 16 is completed.
Compared with the traditional separation column, the separation column has a simpler structure, and can prevent the feeding pipe from knotting during unwinding.
Further, the bottom of the mounting groove 4 is provided with a finger groove 25. Planetary shaft 16 outside is provided with the left hand thread in this embodiment, planetary shaft 16 is connected the back through left hand thread and central screw hole 15, because be the left hand thread, chromatograph clockwise rotation can make it more and more tight, consequently probably will be very tight when shutting down and dismantling, can not pull down by hand, so this embodiment sets up two finger grooves 25 in mounting groove 4 bottom symmetry, the line of two finger grooves 25 all has the contained angle with the length direction and the stopper 23 of central deflector 2, make things convenient for the insertion tool to go the rotation separation post like this, convenient dismantlement, adopt above-mentioned structure more simple and reliable.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Those skilled in the art can make numerous possible variations and modifications to the described embodiments, or modify equivalent embodiments, without departing from the scope of the invention. Therefore, any modification, equivalent change and modification made to the above embodiments according to the technology of the present invention are all within the protection scope of the present invention, unless the content of the technical scheme of the present invention is departed from.
Claims (10)
1. The utility model provides a counter-current chromatography separation column of no adapter which characterized in that: the bobbin comprises a bobbin (1) and a central guide plate (2), wherein an annular winding cavity (3) is formed in the bobbin (1), an installation groove (4) is formed in the middle of the bobbin (1), the central guide plate (2) is arranged in the installation groove (4), and a feeding pipe inlet straight hole (5) and a feeding pipe outlet straight hole (6) are formed in the central guide plate (2); the bobbin (1) is provided with a feeding pipe inlet guide groove (7) and a feeding pipe outlet guide groove (8) on the top end face, one end of the feeding pipe inlet guide groove (7) is communicated with the winding cavity (3), the other end of the feeding pipe inlet guide groove is communicated with the mounting groove (4) through a feeding pipe inlet inclined hole (10), one end of the feeding pipe outlet guide groove (8) is communicated with the winding cavity (3), and the other end of the feeding pipe outlet guide groove is communicated with the mounting groove (4) through a feeding pipe outlet inclined hole (12).
2. The non-adapter countercurrent chromatography separation column of claim 1, wherein: the feeding pipe inlet guide groove (7) comprises a first arc section (71), a first transition section (72) and a second transition section (73), the first transition section (72) and the second transition section (73) are located at two ends of the first arc section (71), the second transition section (73) is communicated with the winding cavity (3) through a feeding pipe inlet (9), the first transition section (72) is communicated with the mounting groove (4) through a feeding pipe inlet inclined hole (10), and the first arc section (71) is in arc transition connection with the first transition section (72) and the second transition section (73).
3. The non-adapter countercurrent chromatography separation column of claim 2, wherein: the feeding pipe outlet guide groove (8) comprises a second arc section (81) and a third transition section (82), one end of the second arc section (81) is communicated with the winding cavity (3) through a feeding pipe outlet (11), the other end of the second arc section (81) is in arc transition connection with the third transition section (82), and the third transition section (82) is communicated with the mounting groove (4) through a feeding pipe outlet inclined hole (12).
4. The non-adapter countercurrent chromatography separation column of claim 3, wherein: the inner wall of the mounting groove (4) is symmetrically provided with mounting tables (13), two ends of the central guide plate (2) are fixed on the mounting tables (13), and the feeding pipe inlet inclined hole (10) and the feeding pipe outlet inclined hole (12) are respectively arranged on the two mounting tables (13).
5. The adapter-free countercurrent chromatographic separation column according to claim 4, wherein: the inclined hole (10) of the feeding pipe inlet and the inclined hole (12) of the feeding pipe outlet are symmetrically and obliquely arranged.
6. The non-adapter countercurrent chromatography separation column of claim 4, wherein: the bottom of the feeding pipe inlet straight hole (5) and the bottom of the feeding pipe outlet straight hole (6) are both provided with guide grooves (14), and the guide grooves (14) of the feeding pipe inlet straight hole (5) and the feeding pipe outlet straight hole (6) are respectively arranged towards the feeding pipe inlet inclined hole (10) and the feeding pipe outlet inclined hole (12) in an inclined mode.
7. The adapter-free countercurrent chromatographic separation column according to claim 1, wherein: the bottom of mounting groove (4) be provided with central screw hole (15), still include planet axle (16), card strip fixing bolt (17) and locking card strip (18), the one end of planet axle (16) with central screw hole (15) threaded connection, be provided with threaded connection hole (19) on the terminal surface of planet axle (16), be provided with counter bore (20) on the terminal surface of planet axle (16), the symmetry is provided with fluting (21) on the terminal surface of planet axle (16), mounting groove (4) bottom corresponds with fluting (21) and is provided with recess (22), the symmetry is provided with stopper (23) on locking card strip (18), the middle part of locking card strip (18) is arranged in counter bore (20), and in recess (22) and fluting (21) are arranged in to stopper (23) of locking card strip (18), card strip fixing bolt (17) pass card strip (18) and threaded connection hole (19).
8. The non-adapter countercurrent chromatography separation column of claim 7, wherein: the bottom of the central threaded hole (15) is a stepped hole, the planet shaft (16) is provided with a limiting step (24), and the limiting step (24) is matched with the stepped hole for limiting.
9. The non-adapter countercurrent chromatography separation column of claim 3, wherein: the feeding pipe inlet (9) is positioned on the inner side of the winding cavity (3), and the feeding pipe outlet (11) is positioned on the outer side of the winding cavity (3).
10. The non-adapter countercurrent chromatography separation column of claim 1, wherein: and a finger groove (25) is formed at the bottom of the mounting groove (4).
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| CN202211151395.6A CN115469047B (en) | 2022-09-21 | 2022-09-21 | Countercurrent chromatographic separation column without adapter |
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