CN115468912A - Optical fiber microcavity laser device integrating biochemical sensing and random label dual functions - Google Patents

Optical fiber microcavity laser device integrating biochemical sensing and random label dual functions Download PDF

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CN115468912A
CN115468912A CN202211069688.XA CN202211069688A CN115468912A CN 115468912 A CN115468912 A CN 115468912A CN 202211069688 A CN202211069688 A CN 202211069688A CN 115468912 A CN115468912 A CN 115468912A
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laser
fiber
random
signal
optical fiber
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王艳琼
龚元
刘艺玲
张雅馨
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University of Electronic Science and Technology of China
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • G02B6/02319—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes characterised by core or core-cladding interface features
    • G02B6/02323—Core having lower refractive index than cladding, e.g. photonic band gap guiding
    • G02B6/02328—Hollow or gas filled core
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G02B6/02314—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes
    • G02B6/02342—Plurality of longitudinal structures extending along optical fibre axis, e.g. holes characterised by cladding features, i.e. light confining region
    • G02B6/02361—Longitudinal structures forming multiple layers around the core, e.g. arranged in multiple rings with each ring having longitudinal elements at substantially the same radial distance from the core, having rotational symmetry about the fibre axis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/067—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components
    • G06K19/07—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components with integrated circuit chips
    • G06K19/077—Constructional details, e.g. mounting of circuits in the carrier
    • G06K19/0772—Physical layout of the record carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0112—Apparatus in one mechanical, optical or electronic block
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G01N2021/391—Intracavity sample

Abstract

The invention discloses an optical fiber microcavity laser device integrating the functions of biochemical sensing and random labeling, and relates to the field of laser sensors. According to the invention, the hollow photonic band gap fiber is utilized, when pump light irradiates the optical fiber, the optical fiber can be used as a Fabry-Perot cavity to form laser resonance because of a Bragg reflection structure formed by high-low refractive index alternate films on the inner wall of the optical fiber; because of the characteristics of the Bragg reflection structure, the laser with short wavelength is reflected back into the cavity by the random microstructure in the cladding through the Fabry-Perot cavity to generate self-mixing interference, thereby generating random longitudinal mode signals. The method has the characteristics of small detection unit volume, small detection sample consumption, large label coding capacity and the like.

Description

Optical fiber microcavity laser device integrating double functions of biochemical sensing and random label
Technical Field
The invention belongs to the field of laser sensors, and particularly relates to an optical fiber microfluidic laser biochemical analysis device integrating biochemical sensing and a high-capacity random label, which realizes two functions of biochemical detection and the high-capacity random label.
Background
Immunoturbidimetry is a common biological assay in clinical testing. The antigen-antibody specificity is combined to form immune complex particles, so that the reaction liquid generates turbidity and generates scattering to incident light, the intensity of the scattered light is in direct proportion to the concentration and the size of the complex particles, and the antigen concentration can be obtained by detecting the intensity difference of the incident light before and after passing through the reaction liquid. However, the traditional detection method has the defects of low sensitivity, large reagent dosage and the like.
The hollow photonic band gap fiber is composed of a cladding consisting of an air fiber core, a Bragg reflection structure and a protective layer, the Bragg reflection structure is formed by periodically overlapping a plurality of medium concentric circles with different refractive indexes, and the high reflectivity can be realized at a specific wave band by adjusting the refractive index of a film material and the thickness of the film. By combining the microfluidic fiber laser technology, the tubular shape of the hollow photonic band gap fiber can be used as a microfluidic channel for filling gain liquid and reaction liquid; meanwhile, the Bragg reflection structure with high reflectivity can provide optical feedback for laser emission, and the resonance of a Fabry-Perot cavity is generated in the radial direction of the section of the optical fiber. A plurality of air channels are embedded in a cladding of the hollow-core photonic band-gap fiber, and the generated short-wave laser is reflected back into the cavity and generates self-mixing interference with signals in the cavity. The laser signals collected at different locations of the fiber are random due to the inability to precisely control the shape of the cladding air channel during fiber draw. In the application scene of large-scale detection, the biological detection function and the sample marking function are indispensable, and the prior art has no equipment which can simultaneously realize the biological detection function with high sensitivity and the random label with large capacity.
Disclosure of Invention
The invention aims to provide a fiber microcavity laser device integrating the functions of biochemical sensing and random labeling aiming at the defects mentioned in the background technology. The device has the characteristics of small detection unit volume, small detection sample consumption, large label coding capacity and the like.
In order to achieve the technical purpose, the solution provided by the invention is as follows: the device comprises a pumping light source module I, a sample control and detection module II and a signal collection and processing module III, wherein the three parts are as follows:
the pumping light source module I is used for providing pumping laser for the sample control and detection module II;
the sample control and detection module II comprises: an electric displacement table (5) and a hollow photonic band gap fiber (6); the inner wall of the hollow-core photonic band-gap fiber (6) is provided with a Bragg reflection structure, and a random microstructure is embedded in each section of the fiber cladding along the axial direction of the fiber; the pump laser vertically irradiates the hollow photonic band gap fiber (6) to generate optical signal output; under the low-energy laser pumping, the wavelength interval of the longitudinal mode of the generated laser signal A is uniform and stable, and the device is used for biochemical sensing; under the pumping of high-energy laser, the longitudinal mode wavelength interval of the generated laser signal B is random and randomly changed along with the position of the optical fiber, and the device is used for generating a large-capacity random label; the limit of the low-energy laser pump and the high-energy laser pump is E, and E is more than 15 mu J/mm 2 (ii) a The electric displacement table (5) accurately moves the hollow photonic band gap fiber (6) along the axial direction to obtain a plurality of groups of random optical signal outputs at different positions of the fiber;
when the device is used for biochemical sensing, the generated laser spectrum result is subjected to integral processing;
when the device is used for generating a large-capacity random label, converting the generated laser spectrum into a binary string; and a plurality of groups of optical signal outputs obtained at different positions of the optical fiber are converted into a plurality of groups of binary character strings with the same number of bits to form a two-dimensional random binary label.
Further, the pump light source module I includes: the device comprises a pulse laser (1), a beam splitter (2), an energy meter (3) and a cylindrical lens (4), wherein the pulse laser (1) outputs pump laser, the pump laser is divided into two vertical beams after passing through the beam splitter (2), one beam is incident to the energy meter (3), and the energy of the beam is monitored in real time; another laser beam passes through the cylindrical lens (4) to form a strip-shaped light spot and vertically converges on the hollow photonic band gap fiber (6);
the signal collection processing module III comprises: the device comprises an adjustable neutral filter (7), a collecting element (8), a transmission optical fiber (9), a spectrum analyzer (10) and a computer (11); the adjustable neutral filter (7) can perform adjustable attenuation on the signal light, the collecting element (8) collects and couples the signal light into the transmission optical fiber (8) and further transmits the signal light to the spectrum analyzer (10), and the spectrum result is transmitted to the computer (11) and is subjected to data processing according to the required function.
Further, when the device is used for generating a large-capacity random label, under the pumping of high-energy laser, a section of the laser signal B is taken, and the rule of converting the laser spectrum of the section into a two-dimensional random binary label is as follows:
step 1: finding the amplitude with the highest laser longitudinal mode intensity in the spectrum, and taking 10% of the amplitude as a threshold; then finding out the wavelength positions of all laser longitudinal mode intensities in the spectrum, wherein the laser longitudinal mode intensities are higher than a threshold value;
step 2: dividing the wavelength range into 50 wavelength intervals at intervals of 0.38nm, and corresponding to 50 binary characters, wherein the first 49 intervals are left-closed and right-open intervals, and the last interval is a closed interval;
and step 3: if the wavelength position obtained in the step 1 is in a certain wavelength interval, the bit corresponding to the interval is digital code "1", otherwise, the bit is digital code "0";
and 4, step 4: converting N groups of optical signal outputs obtained at different positions of the optical fiber into N groups of binary character strings with the same length according to the steps 1-3 to obtain a 50 multiplied by N two-dimensional digital matrix and form a two-dimensional random binary label; wherein the N value can be adjusted and expanded according to application requirements to obtain the code capacity of 2 50×N The two-dimensional random binary label of (1).
Furthermore, the reflectivity of the Bragg reflection structure on the inner wall of the hollow-core photonic band gap fiber (6) is more than 80% in the range from 620nm to 720 nm.
Furthermore, the wavelength of the pulse laser (1) is continuously adjustable between 400nm and 800nm, and the output pulse laser energy is continuously adjustable between 1 mu J and 1 mJ.
Further, when the laser signal is output, the pumping threshold of the laser signal a is smaller than that of the laser signal B.
Further, the center wavelength of the laser signal a is longer than the center wavelength of the laser signal B, and the bandwidths of the laser signal a and the laser signal B do not overlap.
According to the invention, the hollow photonic band gap fiber is utilized, when pump light irradiates the optical fiber, the optical fiber can be used as a Fabry-Perot cavity to form laser resonance because of a Bragg reflection structure formed by high-low refractive index alternating films on the inner wall of the optical fiber; due to the characteristics of the Bragg reflection structure, laser with short wavelength is reflected back into the cavity by the random micro-structure in the cladding through the Fabry-Perot cavity to generate self-mixing interference, so that the laser signal B is a random longitudinal mode signal.
The microfluidic laser can be used for biosensing and generating two-dimensional random binary labels, can highly integrate sensing and marking functions in large-scale detection and other applications, reduces the consumption of samples and reagents, and reduces the cost.
Compared with the prior art, the invention has the following advantages:
1. the invention provides a double-function optical fiber microfluidic laser biochemical analysis device which has the functions of biochemical sensing and high-capacity random labeling and can meet the detection and marking requirements of a large number of samples in the application scene of large-scale detection.
2. The invention uses the hollow photonic band gap fiber as a sensing unit, and the hollow structure has small size, thereby effectively reducing the consumption of detection samples and reagents.
3. The invention utilizes the hollow photonic band gap fiber, can be prepared in batches in hundred meters by the fiber drawing technology, generates a 2500-bit binary label only needing the fiber with the length of 7.5mm, and reduces the cost.
4. According to the laser signal B obtained by the invention, the narrow linewidth characteristic of the longitudinal laser mode is utilized, the laser wavelength range is increased by increasing the length of the scanning optical fiber and replacing the types of organic dyes, and the expansion of the coding capacity is realized.
Drawings
Fig. 1 is a schematic structural diagram of an optical fiber microcavity laser device integrating biochemical sensing and random tag dual functions provided by the invention.
Fig. 2 is a curve of the change of the fiber microfluidic laser spectrum of the fiber microcavity laser device integrating the biochemical sensing and random labeling dual functions with the pumping energy density.
Fig. 3 is a random label example diagram of a fiber microcavity laser device integrating the dual functions of biochemical sensing and random label according to the invention.
FIG. 4 is a curve showing the variation of the laser intensity of the fiber-optic microcavity laser device integrating the biochemical sensing and random labeling functions with the concentration of microalbuminuria.
FIG. 5 is a cross-sectional view of a hollow-core photonic band gap fiber of the fiber microcavity laser device integrating the dual functions of biochemical sensing and random labeling.
Detailed Description
The invention is further described with reference to the following figures and specific examples.
The present embodiment provides an optical fiber microcavity laser device integrating the dual functions of biochemical sensing and random labeling, and a schematic block diagram of the system of the optical fiber microcavity laser device is shown in fig. 1, which specifically includes: pump light source module I, sample control and detection module II, signal collection processing module III, wherein:
the pumping light source module I includes: the device comprises a pulse laser (1), a beam splitter (2), an energy meter (3) and a cylindrical lens (4), wherein the pulse laser (1) outputs pump laser, the pump laser is divided into two vertical beams after passing through the beam splitter (2), one beam is incident to the energy meter (3), and the energy of the beam is monitored in real time; and the other beam of laser forms a strip-shaped light spot through the cylindrical lens (4) and vertically converges on the hollow photonic band gap fiber (6).
The sample control and detection module II comprises: an electric displacement table (5) and a hollow photonic band gap fiber (6); the inner wall of the hollow-core photonic band gap fiber (6) is of a Bragg reflection structure formed by thin films with alternating high and low refractive indexes; a plurality of air channels are embedded in the cladding of the optical fiber along the axial direction of the optical fiber, and the cross section of each air channel is random (figure 5). The pump laser vertically irradiates the hollow photonic band gap fiber (6) to generate optical signal output. When the device is used for biochemical sensing, the wavelength interval of the longitudinal mode of the generated laser signal A is uniform and stable under the pumping of low-energy laser as shown in FIG. 2. When the device is used for generating a large-capacity random label, under the high-energy laser pumping, the longitudinal mode wavelength interval of the generated laser signal B is random and randomly changes along with the position of the optical fiber. The electric displacement platform (5) can accurately move the hollow photonic band gap fiber (6) along the axial direction in a step length of 0.15mm, and a plurality of groups of random optical signal outputs are obtained at different positions of the fiber.
The signal collection processing module III comprises: the device comprises an adjustable neutral filter (7), a collecting element (8), a transmission optical fiber (9), a spectrum analyzer (10) and a computer (11). The adjustable neutral filter (7) can adjustably attenuate signal light, the collecting element (8) collects the signal light in a converging way, the signal light is coupled into the transmission optical fiber (8) and further transmitted to the spectrum analyzer (10), and the spectrum result is transmitted to the computer (11) and is subjected to data processing according to the required functions. When the device is used for biochemical sensing, the generated laser spectrum result is subjected to integration processing. When the device is used for generating a large-capacity random label, the generated laser spectrum is converted into a binary character string according to a certain rule; and converting a plurality of groups of optical signal outputs obtained at different positions of the optical fiber into a plurality of groups of binary character strings with the same digit number to form a two-dimensional random binary label.
When the device is used for generating a large-capacity random label, the pumping energy is high, the adjustable neutral filter (7) is adjusted to be in a high-density state, most of laser signals A are absorbed, and only a small amount of laser signals A are transmitted to the spectrum analyzer (10). The intensity of the laser signal B is greatly enhanced, the wavelength range is 19nm in the spectral range of the laser signal B, the generated laser spectrum is converted into a two-dimensional random binary label, and the longitudinal mode wavelength position where the intensity of all laser longitudinal modes in the spectrum is higher than 10% of the highest intensity in the whole range is firstly found; dividing the wavelength range into 50 wavelength intervals at intervals of 0.38nm, and corresponding to 50-bit binary characters, wherein the first 49 intervals are left-closed right-open intervals, and the last interval is a closed interval; if the longitudinal mode wavelength position is in a certain wavelength interval, the bit corresponding to the interval is digital code '1', otherwise, the bit is digital code '0'. As shown in FIG. 3, 50 sets of optical signal outputs obtained from different positions of the optical fiber are converted into 50 sets of binary character strings with the same length to obtain a 50 × 50 two-dimensional digital matrixAnd forming a two-dimensional random binary label. To obtain a coding capacity of 2 2500 The two-dimensional random binary label of (1).
When the device is used for biosensing, the adjustable neutral optical filter (7) is adjusted to be in a low-density state under the pumping of low-energy laser, and only a laser signal A is generated. Diluting a standard substance (urine microalbumin) according to a concentration gradient of 10 times, respectively adding equivalent protein to be detected and deionized water with various concentrations into a detection reagent to form a reaction group to be detected and a blank control group, incubating at 37 ℃ for 10 minutes, respectively adding 83 mu L of 1.2mM rhodamine B aqueous solution into each group of liquid, and uniformly mixing. Firstly, a blank control group is absorbed into a hollow-core photonic band gap fiber (6) through capillary action, the energy of a pulse laser (1) is adjusted to enable the spectral intensity of a laser signal A to reach the highest value as a reference value, and the spectral intensity corresponding to each concentration of reaction liquid to be detected after incubation at 37 ℃ for 10 minutes is detected under the same energy of the pulse laser (1). The difference between the integrated spectral intensities of the blank control group and the reaction solution to be measured in each concentration was calculated to obtain a curve (fig. 4) showing the change of the integrated spectral intensity difference of the laser signal A relative to the reference value with the change of the concentration of microalbuminuria.
And repeating the measuring steps for the sample to be measured, and substituting the spectral integral intensity difference value of the obtained laser signal A into the change curve to obtain the concentration of the sample to be measured.

Claims (8)

1. The device comprises a pumping light source module I, a sample control and detection module II and a signal collection and processing module III, wherein the three parts are as follows:
the pumping light source module I is used for providing pumping laser for the sample control and detection module II;
the sample control and detection module II comprises: an electric displacement table (5) and a hollow photonic band gap fiber (6); the inner wall of the hollow-core photonic band-gap fiber (6) is provided with a Bragg reflection structure, and a random microstructure is embedded in each section of the fiber cladding along the axial direction of the fiber; the pump laser vertically irradiates the hollow photonic band gap fiber (6) to generate optical signal output; at low energy laser pumpingThe generated laser signal A has uniform and stable longitudinal mode wavelength interval, and the device is used for biochemical sensing; under the high-energy laser pumping, the longitudinal mode wavelength interval of the generated laser signal B is random and randomly changed along with the position of the optical fiber, and the device is used for generating a large-capacity random label; the limit of the low-energy laser pump and the high-energy laser pump is E, and E is more than 15 mu J/mm 2 (ii) a The electric displacement table (5) accurately moves the hollow photonic band gap fiber (6) along the axial direction to obtain a plurality of groups of random optical signal outputs at different positions of the fiber;
when the device is used for biochemical sensing, the generated laser spectrum result is subjected to integration processing;
when the device is used for generating a large-capacity random label, converting the generated laser spectrum into a binary string; and a plurality of groups of optical signal outputs obtained at different positions of the optical fiber are converted into a plurality of groups of binary character strings with the same number of bits to form a two-dimensional random binary label.
2. The integrated biochemical sensing and stochastic tag dual-function fiber microcavity laser device of claim 1, wherein the pump light source module I comprises: the device comprises a pulse laser (1), a beam splitter (2), an energy meter (3) and a cylindrical lens (4), wherein the pulse laser (1) outputs pump laser, the pump laser is divided into two vertical beams after passing through the beam splitter (2), one beam is incident to the energy meter (3), and the energy of the beam is monitored in real time; another laser beam passes through the cylindrical lens (4) to form a strip-shaped light spot and vertically converges on the hollow photonic band gap fiber (6);
the signal collection processing module III comprises: the device comprises an adjustable neutral filter (7), a collecting element (8), a transmission optical fiber (9), a spectrum analyzer (10) and a computer (11); the adjustable neutral filter (7) can perform adjustable attenuation on the signal light, the collecting element (8) collects and couples the signal light into the transmission optical fiber (8) and further transmits the signal light to the spectrum analyzer (10), and the spectrum result is transmitted to the computer (11) and is subjected to data processing according to the required function.
3. The integrated biochemical sensing and stochastic label dual-function fiber microcavity laser device of claim 1, wherein when the device is used to generate a large-capacity stochastic label, a section of laser signal B is taken under high-energy laser pumping, and the rule for converting the end laser spectrum into a two-dimensional stochastic binary label is as follows:
step 1: finding the amplitude with the highest laser longitudinal mode intensity in the spectrum, and taking 10% of the amplitude as a threshold; then finding out the wavelength positions of all laser longitudinal mode intensities in the spectrum, wherein the laser longitudinal mode intensities are higher than a threshold value;
step 2: dividing the wavelength range into 50 wavelength intervals at intervals of 0.38nm, and corresponding to 50 binary characters, wherein the first 49 intervals are left-closed and right-open intervals, and the last interval is a closed interval;
and step 3: if the wavelength position obtained in the step 1 is in a certain wavelength interval, the bit corresponding to the interval is digital code "1", otherwise, the bit is digital code "0";
and 4, step 4: converting N groups of optical signal outputs obtained at different positions of the optical fiber into N groups of binary character strings with the same length according to the steps 1-3 to obtain a 50 multiplied by N two-dimensional digital matrix and form a two-dimensional random binary label; wherein the N value can be adjusted and expanded according to application requirements to obtain the code capacity of 2 50×N The two-dimensional random binary label of (1).
4. The integrated biochemical sensing and random labeling dual-function fiber microcavity laser device according to claim 1, wherein the reflectivity of the bragg reflection structure on the inner wall of the hollow-core photonic band gap fiber (6) is greater than 80% from 620nm to 720 nm.
5. The integrated biochemical sensing and random labeling dual-function fiber microcavity laser device according to claim 1, wherein the wavelength of the pulse laser (1) is continuously tunable between 400nm and 800nm, and the output pulse laser energy is continuously tunable between 1 μ J and 1 mJ.
6. The integrated biochemical sensing and random labeling dual-function fiber microcavity laser device of claim 1, wherein the pumping threshold of laser signal a is less than the pumping threshold of laser signal B when outputting the laser signal.
7. The fiber optic microcavity laser device of claim 1, wherein the center wavelength of the laser signal a is longer than the center wavelength of the laser signal B, and the bandwidths of the laser signal a and the laser signal B do not overlap.
8. The integrated biochemical sensing and stochastic tag dual-function fiber microcavity laser device of claim 1, wherein a plurality of air channels are embedded in the fiber cladding along the fiber axis, each air channel having a random cross-sectional shape.
CN202211069688.XA 2022-09-02 2022-09-02 Optical fiber microcavity laser device integrating biochemical sensing and random label dual functions Pending CN115468912A (en)

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