CN115461083A - 用于在体内向免疫细胞递送mRNA的基于咪唑的合成类脂质 - Google Patents

用于在体内向免疫细胞递送mRNA的基于咪唑的合成类脂质 Download PDF

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CN115461083A
CN115461083A CN202180032365.0A CN202180032365A CN115461083A CN 115461083 A CN115461083 A CN 115461083A CN 202180032365 A CN202180032365 A CN 202180032365A CN 115461083 A CN115461083 A CN 115461083A
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lipidoid
alkyl
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许巧兵
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Tufts University
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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CN202180032365.0A 2020-03-02 2021-03-02 用于在体内向免疫细胞递送mRNA的基于咪唑的合成类脂质 Pending CN115461083A (zh)

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US202062983997P 2020-03-02 2020-03-02
US62/983997 2020-03-02
PCT/US2021/020450 WO2021178396A1 (en) 2020-03-02 2021-03-02 Imidazole-based synthetic lipidoids for in vivo mrna delivery into immune cells

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CN115461083A true CN115461083A (zh) 2022-12-09

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US (1) US20230097743A1 (enExample)
EP (1) EP4114467A4 (enExample)
JP (1) JP7716112B2 (enExample)
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CA (1) CA3170055A1 (enExample)
WO (1) WO2021178396A1 (enExample)

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KR20230005367A (ko) * 2020-05-04 2023-01-09 트러스티즈 오브 터프츠 칼리지 뇌 전달을 위한 합성 지질-유사 물질
US20250268828A1 (en) * 2021-09-30 2025-08-28 Orna Therapeutics, Inc. Lipid Nanoparticle Compositions for Delivering Circular Polynucleotides
WO2023081526A1 (en) 2021-11-08 2023-05-11 Orna Therapeutics, Inc. Lipid nanoparticle compositions for delivering circular polynucleotides
CN114805212B (zh) * 2022-02-22 2024-06-18 中国科学院基础医学与肿瘤研究所(筹) 用于递送治疗或预防剂的脂质和脂质组合物
CN119486721A (zh) 2022-07-08 2025-02-18 宝利普拉斯生物转染公司 包含基于咪唑鎓的阳离子脂质的脂质纳米颗粒
WO2024205657A2 (en) * 2023-03-29 2024-10-03 Orna Therapeutics, Inc. Lipids and lipid nanoparticle compositions for delivering polynucleotides
WO2025124548A1 (zh) 2023-12-13 2025-06-19 上海瑞宏迪医药有限公司 一种咪唑类脂质及其应用

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EP4114467A4 (en) 2024-04-17
JP7716112B2 (ja) 2025-07-31
US20230097743A1 (en) 2023-03-30
WO2021178396A1 (en) 2021-09-10
EP4114467A1 (en) 2023-01-11
JP2023516977A (ja) 2023-04-21
CA3170055A1 (en) 2021-09-10

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