CN115429707A - Fullerene composition and application thereof - Google Patents
Fullerene composition and application thereof Download PDFInfo
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- CN115429707A CN115429707A CN202211118770.7A CN202211118770A CN115429707A CN 115429707 A CN115429707 A CN 115429707A CN 202211118770 A CN202211118770 A CN 202211118770A CN 115429707 A CN115429707 A CN 115429707A
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- sodium hyaluronate
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- 239000000203 mixture Substances 0.000 title claims abstract description 86
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 229910003472 fullerene Inorganic materials 0.000 title claims abstract description 68
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 100
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- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 94
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- 150000003077 polyols Chemical class 0.000 claims description 15
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- 238000002360 preparation method Methods 0.000 claims description 8
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- 239000000463 material Substances 0.000 description 7
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- 239000000725 suspension Substances 0.000 description 4
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- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
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- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
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- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
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- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
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- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 229940117969 neopentyl glycol Drugs 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 description 1
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- 159000000000 sodium salts Chemical class 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The present application discloses a composition, and uses of the composition. The composition comprises fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and polyhydric alcohol. The mass ratio of the fullerene, the high molecular weight sodium hyaluronate, the medium molecular weight sodium hyaluronate, the low molecular weight sodium hyaluronate and the polyalcohol is (0.01-0.1): (0.1-1): (0.2-2): (2-4): (20-40). The composition disclosed by the application has obvious effects on scavenging free radicals, fading red, relieving, moisturizing, improving skin elasticity, improving barrier function, repairing and the like.
Description
Technical Field
The application relates to the field of daily-use chemical industry, in particular to a composition containing fullerene and application tolerance thereof.
Background
Due to the influence of factors such as work/life pressure, environmental deterioration and the like in modern society, the skin of a human body has the problems of abnormal oil production, dryness, large pores, toxin deposition and the like in an early age period. Meanwhile, the human body can generate various free radicals in the process of metabolism. While the vast majority of free radicals are oxygen radicals. Human cells are functionally impaired by the attack of oxygen radicals, thereby causing problems such as decreased function and skin aging.
Fullerene is a third allotrope found in elemental carbon, which is a large pi-bonded conjugated system composed of multiple P orbitals. Such a structure allows the fullerene to have a strong ability to accept electrons. Due to the unique structure and physicochemical properties of fullerene, the fullerene has excellent free radical scavenging performance, is called as free radical sponge, and simultaneously shows excellent oxidation resistance. So that it has attracted much attention in the fields of cosmetic materials, biomedicines, and the like.
Disclosure of Invention
The composition has obvious effects on scavenging free radicals, fading red, relieving, moisturizing, improving skin elasticity, improving barrier function, repairing and the like. The composition can be used in the preparation of cosmetic or cosmeceutical products, or in the preparation of cosmetic or cosmeceutical devices.
In one aspect, a composition is provided that includes a fullerene, a large molecular weight sodium hyaluronate, a medium molecular weight sodium hyaluronate, a small molecular weight sodium hyaluronate, and a polyol. The mass ratio of the fullerene, the high molecular weight sodium hyaluronate, the medium molecular weight sodium hyaluronate, the low molecular weight sodium hyaluronate and the polyalcohol is (0.01-0.1): (0.1-1): (0.2-2): (2-4): (20-40).
In some embodiments, the composition comprises the fullerene, the sodium hyaluronate with a large molecular weight, the sodium hyaluronate with a medium molecular weight, the sodium hyaluronate with a small molecular weight and the polyalcohol in a mass ratio of (0.02-0.06): 0.1: (0.2-0.8): 4: (20-30).
In some embodiments, the high molecular weight sodium hyaluronate has a molecular weight of 1000kDa to 2000kDa, the medium molecular weight sodium hyaluronate has a molecular weight of 200kDa to 800kDa, and the low molecular weight sodium hyaluronate has a molecular weight of no more than 5kDa to 50kDa; or the molecular weight of the large molecular weight sodium hyaluronate is 1200kDa-1500kDa, the molecular weight of the medium molecular weight sodium hyaluronate is 300kDa-700kDa, and the molecular weight of the small molecular weight sodium hyaluronate is 10kDa-20kDa.
In some embodiments, the high molecular weight sodium hyaluronate has a molecular weight of 1280kDa, the medium molecular weight sodium hyaluronate has a molecular weight of 600kDa, and the low molecular weight sodium hyaluronate has a molecular weight of 10kDa.
In some embodiments, the fullerene is any one or a mixture of C60, C44, C50, C70, C76, C80, C84, C90, C94, C120, C180, C540; alternatively, the fullerene is C60, C70, or a mixture of C60 and C70.
In some embodiments, the polyol is butanediol.
In some embodiments, the composition further comprises a solvent comprising one or more of: deionized water, ethanol, isopropanol, n-butanol or pentanol.
In some embodiments, the solvent is deionized water.
The application also provides an application of the composition in preparing cosmetic or cosmetic products.
In a further aspect, the present application provides the use of a composition as described above in the manufacture of a device for cosmetic or cosmetology.
Drawings
The present application will be further explained by way of exemplary embodiments, which will be described in detail by way of the accompanying drawings. These embodiments are not intended to be limiting, and in these embodiments like numerals are used to indicate like structures, wherein:
FIG. 1 is a graph of the results of a facial redness removal test for compositions according to some embodiments of the present application;
figure 2 is a graph of the results of a post histamine challenge repair test for compositions according to some embodiments presented herein.
Detailed Description
As used in this application and the appended claims, the terms "a," "an," "the," and/or "the" are not intended to be inclusive in the singular, but rather are intended to be inclusive in the plural unless the context clearly dictates otherwise. In general, the terms "comprises" and "comprising" merely indicate that steps and elements are included which are explicitly identified, that the steps and elements do not form an exclusive list, and that a method or apparatus may include other steps or elements. The numerical ranges used in this application are intended to represent each and every value included in the range in a concise and concise manner.
The composition disclosed herein comprises fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate, and a polyol.
Fullerene can refer to a hollow molecule consisting entirely of carbon atoms, which is spherical, ellipsoidal, cylindrical or tubular in shape. The structure is a convex polyhedron formed by pentagonal faces and hexagonal faces. The number of pentagonal faces constituting the fullerene is 12, and the number of hexagonal faces is n-10. In the present application, fullerenes may include unmodified or modified fullerenes. Illustratively, the unmodified fullerene may be a fullerene of any type including those represented by the formula C2n, consisting solely of carbon atoms. Wherein n =10, 12, 13, 14 … …. In the present application, the unmodified fullerene may also be referred to as an empty fullerene. The modified fullerene can be various fullerenes obtained through atom doping or chemical reaction. Such as endohedral fullerenes, heterocyclic fullerenes or water-soluble fullerenes. The metal fullerene may be a compound in which various atoms, ions, or atom clusters are embedded in the hollow portion of a hollow fullerene, and may be represented by the formula M @ c2n, where M represents an embedded atom, ion, or atom cluster. For example, metal atoms such as scandium, yttrium, lanthanides, and the like. Where M may represent a reasonable combination of one or more elements. The heterocyclic fullerene may include a compound obtained by substituting an element in a hollow fullerene. For example, carbon atoms are substituted with oxygen atoms or nitrogen atoms. Water-soluble fullerenes may include water-soluble modifications of an empty or endofullerene, for example, by attaching hydrophilic groups such as hydroxyl, carboxyl, thiol, amino groups, etc., to the outer carbon atoms of the empty or endofullerene.
In some embodiments, the fullerene may be a mixture of one or more of the fullerenes described above. For example, the fullerene may be a combination of one or more of an empty fullerene, an endohedral fullerene, a heterocyclic fullerene, or a water-soluble fullerene. In some embodiments, the fullerene may comprise any one or a mixture of C44, C50, C60, C70, C76, C80, C84, C90, C94, C120, C180, C540. Alternatively or preferably, the fullerene is C60, C70 or a mixture of C60 and C70.
Hyaluronic acid may refer to a high molecular polymer, a disaccharide glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Illustratively, the hyaluronic acid may include normal hyaluronic acid or derivatives of hyaluronic acid, including but not limited to hydrolyzed hyaluronic acid, acetylated hyaluronic acid, hyaluronic acid cross-linked polymers, silanized hyaluronic acid, and the like, or any combination thereof. Accordingly, sodium hyaluronate may also include sodium salts of the above various types of hyaluronic acid. The sodium hyaluronate of different molecular weights is used in combination according to the molecular weight of the sodium hyaluronate (about 5 to 2 million daltons). In some embodiments, the sodium hyaluronate comprises a large molecular weight sodium hyaluronate, a medium molecular weight sodium hyaluronate, and a small molecular weight sodium hyaluronate. In some embodiments, the large molecular weight sodium hyaluronate may have a molecular weight of 1000kDa to 2000kDa. Illustratively, the molecular weight of the high molecular weight sodium hyaluronate may be 1100kDa to 1900kDa, 1200kDa to 1800kDa, 1200kDa to 1700kDa, 1200kDa to 1600kDa, 1200kDa to 1500kDa, and the like. Alternatively or preferably, the large molecular weight sodium hyaluronate may have a molecular weight of 1200kDa to 1500kDa. Alternatively or preferably, the molecular weight of the high molecular weight sodium hyaluronate may be 1250kDa, 1280kDa, 1300kDa, 1350kDa, 1400kDa, 1450kDa, 1500kDa. Alternatively or preferably, the molecular weight of the high molecular weight sodium hyaluronate may be 1280kDa. The medium molecular weight sodium hyaluronate may have a molecular weight of 200kDa to 800kDa. Illustratively, the medium molecular weight sodium hyaluronate can have a molecular weight of 220kDa to 780kDa, 240kDa to 760kDa, 260kDa to 740kDa, 280kDa to 720kDa, 300kDa to 700kDa, and the like. Alternatively or preferably, the medium molecular weight sodium hyaluronate may have a molecular weight of 300kDa to 700kDa, 360kDa to 680kDa, 420kDa to 660kDa, 480kDa to 640kDa, 540kDa to 620kDa, and the like. Alternatively or preferably, the medium molecular weight sodium hyaluronate may have a molecular weight of 600kDa. The small molecular weight sodium hyaluronate may have a molecular weight of 5kDa to 50kDa. Illustratively, the small molecular weight sodium hyaluronate may have a molecular weight of 6kDa to 40kDa, 8kDa to 30kDa, 10kDa to 20kDa, or the like. Alternatively or preferably, the small molecular weight sodium hyaluronate may have a molecular weight of 10kDa.
The polyol may be an alcohol having two or more hydroxyl groups in the molecule. Exemplary polyols may include, but are not limited to, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, neopentyl glycol, hexylene glycol, octylene glycol, glycerol (glycerin), pentaerythritol, xylitol, sorbitol, and the like, or any combination thereof. In some embodiments, the polyol can be butanediol, including 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, and 2,3-butanediol. Alternatively or preferably, the polyol may be 1,3-butanediol.
In some embodiments, the composition can have a mass ratio of fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate, and polyol of (0.01-0.1): (0.1-1): (0.2-2): (2-4): (20-40). Alternatively or preferably, the mass ratio of fullerene, sodium hyaluronate with large molecular weight, sodium hyaluronate with medium molecular weight, sodium hyaluronate with small molecular weight and polyalcohol in the composition can be (0.02-0.06): 0.1: (0.2-0.8): 4: (20-30). Alternatively or preferably, the mass ratio of fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and polyol in the composition may be 0.04:0.1:0.2:4:20. alternatively or preferably, the mass ratio of fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and polyol in the composition may be 0.04:0.1:0.5:4:20. alternatively or preferably, the mass ratio of fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and polyol in the composition may be 0.04:0.1:0.8:4:30.
in some embodiments, the composition may be presented in a powdered form. For example, the components may be mixed well in a solvent such as water, followed by solvent removal and drying to provide a powdered composition. The composition may also be presented in the form of a suspension. For example, a fullerene powder and a sodium hyaluronate powder having each molecular weight are mixed uniformly, added to a solvent in which a polyhydric alcohol is dissolved, and homogenized to obtain a suspension of the composition. The composition may also be presented in the form of a solution. For example, the components are mixed uniformly in a solvent and present as a solution.
In some embodiments, the composition further comprises a solvent. That is, the composition may be presented in the form of a solution. The solvent may include one or more of deionized water, ethanol, isopropanol, n-butanol, pentanol, and the like. In some embodiments, the solvent may be deionized water. For illustrative purposes, the preparation of the composition in solution form may be as follows.
The fullerene powder and the sodium hyaluronate powder are uniformly mixed to obtain the mixture powder of the fullerene and the sodium hyaluronate. In this operation, a sieving treatment may also be performed. In the next processing step, the mixture powder can be added into a solvent, and a suspension of fullerene and sodium hyaluronate can be obtained after operations such as stirring or homogenization. And homogenizing the suspension under high pressure to obtain the fullerene sodium hyaluronate compound. The fullerene sodium hyaluronate powder can be obtained after the compound is filtered, concentrated and dried. The powder is dispersed in a solvent system containing a polyhydric alcohol such as butanediol, for example, in an aqueous solution of butanediol to give a final composition.
The composition disclosed in the application can be used for preparing a cosmetic or makeup product. For example, the composition is used in the preparation of cosmetic or toiletry lotions, water, milk, creams, essences, and the like. The composition may also be used with other adjuvants during the preparation process. The auxiliary materials can comprise grease, a surfactant, a pigment, a flavoring agent, an antioxidant, a chelating agent and the like.
The compositions disclosed herein can be used to prepare devices for cosmetic or toiletry purposes. The devices may include facial masks, eye masks, wet wipes, cotton sticks, lotions, dressings, and the like. The device may be the result of applying the composition onto a particular material. The specific material includes but is not limited to a label, a wet tissue, a towel, a paper towel, gauze, a cotton stick, non-woven fabrics, high polymer materials, medical dressings, plastic model non-stick gauze, vaseline oil gauze, a semi-permeable film, a foam auxiliary material and the like. Alternatively or preferably, the device may be a mask.
Examples
The present application is further illustrated by the following examples and provides data support for the benefits of the present application. The application is not limited by these examples.
EXAMPLE 1 preparation of Fullerene-containing compositions
Sodium hyaluronate and fullerene were complexed in different mass ratios selected according to table 1 and dispersed in aqueous solution of butylene glycol to obtain the final compositions 1-9.
Table 1 composition ratio of each component
Example 2 stability test-high temperature test
The compositions 7, 8 and 9 of example 1 were selected and placed at an ambient temperature of 60 ℃. The composition properties and the combined five fullerene contents are detected at the beginning of the test, after 1 month, after 2 months and after 3 months, respectively. The results are shown in Table 2.
TABLE 2 high temperature testing of compositions
The results in table 2 show that compositions 7, 8 and 9 all retain good stability after 90 days of high temperature testing.
Example 3 stability testing-Hot and Cold cycle testing
After selecting the composition 7, the composition 8 and the composition 9 in the example 1, circulating the mixture at-20 ℃ for 24 hours and 40 ℃ for 24 hours for 5 times, the properties of the compositions and the contents of five kinds of fullerene in the compositions are detected. The results are shown in Table 3.
TABLE 3 composition Cold thermal cycling test
The results in Table 3 show that samples Nos. 8 and 9 retain good stability after being subjected to the cooling-heating cycle test at-20 ℃ and 40 ℃.
Example 4 skin moisturization and elasticity test
Skin moisturization and elasticity tests were performed using control example A, B and C with composition 8.
Wherein, the comparison example A is a mixture of fullerene and high molecular weight sodium hyaluronate, the comparison example B is a mixture of fullerene and medium molecular weight sodium hyaluronate, and the comparison example C is a mixture of fullerene and low molecular weight sodium hyaluronate. Control A, B and C were prepared as aqueous formulations with composition 8 and applied to the inside of the forearm of the human body, and the moisture content of the skin before and after application was tested and tested for skin elasticity. The results are shown in tables 4 and 5.
TABLE 4 skin moisture retention assay
TABLE 5 skin elasticity measurement
As shown in tables 4 and 5, the moisture retention and skin elasticity of the compound of fullerene and sodium hyaluronate with various molecular weights are obviously better than those of sodium hyaluronate with one molecular weight.
Example 5 facial Dereddening Effect test
The control A, B and C were used in the facial redness-removing effect test with composition 9.
Of these, comparative examples A, B and C are the same as in example 4. The control examples A, B, C and the composition 9 are prepared into mask products, the facial conditions of a user of the mask products before and after use are tested, and the facial red removing effect of the mask prepared by the control examples A, B, C and the composition 9 is determined. The results are shown in FIG. 1.
In fig. 1, D denotes composition 9. According to the figure 1, the fullerene and the sodium hyaluronate with various molecular weights are compounded to prepare the mask product, the red removing effect is far better than that of the sodium hyaluronate with one molecular weight which is singly used, and the red removing effect of the sodium hyaluronate with the molecular weight in the use process is better than that of the sodium hyaluronate with the large/small molecular weights.
Example 6 testing of the repair Effect after Histamine stimulation
The post-histamine-stimulated repair effect test was performed using control example A, B as well as C, composition 9 and the blank.
Of these, the comparative examples A, B and C are the same as those in example 4. The blank control was a composition without fullerene (comprising sodium hyaluronate of the three molecular weights mentioned above and a polyol). Comparative examples A, B and C were prepared as aqueous formulations with composition 9 and tested according to the following procedure:
1. sticking the inner side skin of the forearm of the human body by using a transparent adhesive tape, damaging skin tissues and repeating for 10 times;
2. taking 4 squares of 3cm to 3cm on the left and right small arms respectively as investigation parts;
3. stimulating the test area with histamine for 10min;
4. after the action time is over, the test part is smeared with the aqueous solution prepared by the composition 9 and the control example A, B and C respectively, and the test part is photographed and observed after the action time is 30min and 60 min.
The results are shown in FIG. 2. In fig. 2, D denotes composition 9. As can be seen from fig. 2, the aqueous product prepared by compounding the fullerene and the sodium hyaluronate with various molecular weights is prepared by compounding the fullerene and the sodium hyaluronate with various molecular weights, so that the effect of relieving skin redness and swelling after histamine stimulation is far better than that of an aqueous product prepared by singly compounding one sodium hyaluronate with large or medium molecular weight and the fullerene, and the effect of relieving the aqueous product prepared by compounding the fullerene and the sodium hyaluronate with small molecular weight is equivalent to that of an aqueous product prepared by compounding the fullerene and the sodium hyaluronate with various molecular weights.
The composition containing fullerene disclosed by the application has the advantages of low cost, stable property, and remarkable effects of removing free radicals, removing red on the face, preserving moisture, improving skin elasticity and stimulating and repairing. Meanwhile, the composition has wide applicability and can be widely applied to cosmetics such as cream, emulsion, liquid and the like.
Having thus described the basic concept, it will be apparent to those skilled in the art that the foregoing detailed disclosure is to be considered as illustrative only and not limiting of the application. Various modifications, improvements and adaptations to the present application may occur to those skilled in the art, although not explicitly described herein. Such alterations, modifications, and improvements are intended to be suggested herein and are intended to be within the spirit and scope of the exemplary embodiments of this application.
Also, this application uses specific language to describe embodiments of the application. Reference throughout this specification to "one embodiment," "an embodiment," and/or "some embodiments" means that a particular feature, structure, or characteristic described in connection with at least one embodiment of the present application is included in at least one embodiment of the present application. Therefore, it is emphasized and should be appreciated that two or more references to "one embodiment," "an embodiment," or "an alternative embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, certain features, structures, or characteristics may be combined as suitable in one or more embodiments of the application.
Similarly, it should be noted that in the preceding description of embodiments of the application, various features are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure aiding in the understanding of one or more of the embodiments. This method of disclosure, however, is not intended to require more features than are expressly recited in the claims. Indeed, the embodiments may be characterized as having less than all of the features of a single embodiment disclosed above.
Numerals describing the number of components, attributes, etc. are used in some embodiments, it being understood that such numerals used in the description of the embodiments are modified in some instances by the use of the modifier "about", "approximately" or "substantially". Unless otherwise indicated, "about", "approximately" or "substantially" indicates that the number allows a variation of ± 20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximations that may vary depending upon the desired properties of the individual embodiments. In some embodiments, the numerical parameter should take into account the specified significant digits and employ a general digit-preserving approach. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the range are approximations, in the specific examples, such numerical values are set forth as precisely as possible within the scope of the application.
The entire contents of each patent, patent application publication, and other material cited in this application, such as articles, books, specifications, publications, documents, and the like, are hereby incorporated by reference into this application. Except where the application is filed in a manner inconsistent or contrary to the present disclosure, and except where the claim is filed in its broadest scope (whether present or later appended to the application) as well. It is noted that the descriptions, definitions and/or use of terms in this application shall control if they are inconsistent or contrary to the statements and/or uses of the present application in the material attached to this application.
Finally, it should be understood that the embodiments described herein are merely illustrative of the principles of embodiments of the present application. Other variations are also possible within the scope of the present application. Thus, by way of example, and not limitation, alternative configurations of the embodiments of the present application may be viewed as being consistent with the teachings of the present application. Accordingly, the embodiments of the present application are not limited to only those embodiments explicitly described and depicted herein.
Claims (10)
1. A composition, characterized in that the composition comprises:
fullerene, high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and polyol; wherein the content of the first and second substances,
the mass ratio of the fullerene, the high molecular weight sodium hyaluronate, the medium molecular weight sodium hyaluronate, the low molecular weight sodium hyaluronate and the polyalcohol is (0.01-0.1): (0.1-1): (0.2-2): (2-4): (20-40).
2. The composition of claim 1, wherein the fullerene, the sodium hyaluronate with large molecular weight, the sodium hyaluronate with medium molecular weight, the sodium hyaluronate with small molecular weight and the polyol are present in a mass ratio of (0.02-0.06): 0.1: (0.2-0.8): 4: (20-30).
3. The composition according to claim 1 or 2, wherein the large molecular weight sodium hyaluronate has a molecular weight of 1000kDa to 2000kDa, the medium molecular weight sodium hyaluronate has a molecular weight of 200kDa to 800kDa, and the small molecular weight sodium hyaluronate has a molecular weight of 5kDa to 50kDa; or the molecular weight of the large molecular weight sodium hyaluronate is 1200kDa-1500kDa, the molecular weight of the medium molecular weight sodium hyaluronate is 300kDa-700kDa, and the molecular weight of the small molecular weight sodium hyaluronate is 10kDa-20kDa.
4. The composition according to claim 3, wherein the large molecular weight sodium hyaluronate has a molecular weight of 1280kDa, the medium molecular weight sodium hyaluronate has a molecular weight of 600kDa, and the small molecular weight sodium hyaluronate has a molecular weight of 10kDa.
5. The composition of claim 1 or 2, wherein the fullerene is any one or a mixture of C44, C50, C60, C70, C76, C80, C84, C90, C94, C120, C180, C540; alternatively, the fullerene is C60, C70, or a mixture of C60 and C70.
6. Composition according to claim 1 or 2, characterized in that the polyol is butanediol.
7. The composition of claim 1 or 2, further comprising a solvent, the solvent comprising one or more of: deionized water, ethanol, isopropanol, n-butanol or pentanol.
8. The composition of claim 7, wherein the solvent is deionized water.
9. Use of a composition according to any one of claims 1 to 8 for the preparation of a cosmetic or toiletry product.
10. Use of a composition according to any one of claims 1 to 8 for the preparation of a device for cosmetic or cosmetology.
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