CN115389281A - Biological sample pretreatment device and medical analysis system - Google Patents

Abstract

The invention relates to a biological sample pretreatment device and a medical analysis system, wherein the biological sample pretreatment device comprises: the device comprises a moving assembly, at least two pretreatment assemblies and a lifting assembly. At least two preprocessing components are arranged on the movable component in a lifting mode, and the preprocessing components are provided with butt joint parts. The lifting component is provided with a lifting part matched with the butt joint part. The moving assembly is used for movably adjusting the positions of at least two pretreatment assemblies so as to enable the butt joint part of one pretreatment assembly to move to the lifting part. The lifting component is used for driving the butt joint part to lift through the lifting part so as to enable the pretreatment component to lift and contact with the biological sample liquid carrier. Therefore, the at least two pretreatment assemblies share the same lifting assembly, and each pretreatment assembly is not required to be provided with one lifting assembly, so that the structure of the biological sample pretreatment device can be greatly simplified, the volume of the biological sample pretreatment device is small, and the cost is low.

Description

Biological sample pretreatment device and medical analysis system

Technical Field

The invention relates to the technical field of medical instruments, in particular to a biological sample pretreatment device and a medical analysis system.

Background

Separation and purification of biological samples are one of the important technologies in biological and medical technologies, and especially in the application of in vitro diagnostic technologies, the pretreatment effect of biological samples is very important for the subsequent detection and diagnosis. For example, magnetic particles can be used for separation of biomolecules such as proteins and nucleic acids, and for separation and purification of nucleic acids, nanoscale magnetic particles are used. The pretreatment method of biological samples based on magnetic separation generally comprises the steps of cell lysis, DNA adsorption, magnetic separation, heating, uniform mixing and the like. However, the corresponding automated instruments on the market are often bulky, complex in structure, expensive, and not easily portable.

Disclosure of Invention

Accordingly, there is a need to overcome the drawbacks of the prior art and to provide a biological sample pretreatment device and a medical analysis system, which have a simplified structure, a smaller volume and a lower cost.

The technical scheme is as follows: a biological sample pretreatment device, comprising: the device comprises a moving assembly and at least two pretreatment assemblies, wherein the at least two pretreatment assemblies are arranged on the moving assembly in a lifting manner and are provided with butt joint parts; and the lifting component is provided with a supporting part matched with the butt joint part, the moving component is used for moving and adjusting at least two positions of the pretreatment component so as to enable one of the positions to move to the butt joint part of the pretreatment component, the lifting component is used for driving the butt joint part to lift through lifting, so that the pretreatment component is lifted and contacted with a biological sample liquid carrier.

When one of the pretreatment components is required to be used for pretreating a biological sample liquid carrier, the position of one of the pretreatment components is adjusted through the movement of the moving component, so that the butt joint part of the pretreatment component moves onto the lifting part; then, the lifting part of the lifting component drives the butt joint part to move up and down, so that the pretreatment component can lift and contact with a biological sample liquid carrier, and the pretreatment component can carry out pretreatment operation on the biological sample liquid carrier; after the pretreatment is finished, the pretreatment module is separated from the biological sample liquid carrier by lowering the position of the pretreatment module through the lifting module, and the pretreatment module is moved away from the lifting module through the moving module, and the pretreatment operation can be carried out on other pretreatment modules in a similar manner. Therefore, the at least two pretreatment assemblies share the same lifting assembly, and each pretreatment assembly is not required to be provided with one lifting assembly, so that the structure of the biological sample pretreatment device can be greatly simplified, the volume of the biological sample pretreatment device is small, and the cost is low.

In one embodiment, the biological sample pretreatment device further comprises a stent; the moving component comprises a sliding plate which is arranged on the bracket in a sliding way and a first power mechanism which is arranged on the bracket; the first power mechanism is used for driving the sliding plate to slide on the bracket so as to adjust the position of the sliding plate; at least two pretreatment component sets up liftably on the sliding plate.

In one embodiment, a first slide rail is arranged on the bracket, a first slide block is arranged on the sliding plate, and the first slide block is slidably arranged on the first slide rail.

In one embodiment, the lifting assembly includes a second power mechanism mounted on the bracket, and the second power mechanism is used for driving the lifting part to lift.

In one embodiment, the biological sample pretreatment device further comprises a first sensing component arranged on the bracket, and the first sensing component is used for sensing the operation position of the lifting part; the biological sample pretreatment device also comprises a second sensing component arranged on the bracket, and the second sensing component is used for sensing the running position of the sliding plate.

In one embodiment, the biological sample pretreatment device further comprises a main shaft and a shaft sleeve which is rotatably sleeved on the main shaft; the moving assembly comprises a rotating tray fixedly arranged on the shaft sleeve and a third power mechanism for driving the rotating tray to rotate; at least two pretreatment assemblies are arranged on the rotary tray in a liftable manner; the lifting component is arranged on the main shaft or the external frame.

In one embodiment, the biological sample pretreatment device further comprises a code wheel fixedly arranged on the shaft sleeve, and a detection element arranged on an external frame; the coded disc is provided with a detection port, and the detection element can acquire the rotating position of the coded disc when sensing the detection port.

In one embodiment, the number of the detection ports is at least two, at least two detection ports are sequentially arranged on the code disc at intervals, and at least two detection ports are arranged in one-to-one correspondence with at least two preprocessing assemblies.

In one embodiment, the biological sample pretreatment device further comprises a lifting guide assembly mounted on the moving assembly; the number of the lifting guide assemblies is at least two, and the at least two lifting guide assemblies are arranged in one-to-one correspondence with the at least two pretreatment assemblies; the pretreatment assembly is arranged on the lifting guide assembly in a sliding mode.

In one embodiment, the biological sample pretreatment device further comprises at least two first elastic members; the at least two first elastic pieces and the at least two preprocessing assemblies are arranged in a one-to-one correspondence mode, and the preprocessing assemblies are connected with the moving assemblies through the corresponding first elastic pieces.

In one embodiment, the abutting portion is provided with a roller, the lifting portion is provided with a sliding groove capable of accommodating the roller, and the roller of the pretreatment assembly can move into or out of the sliding groove when the movement assembly moves to adjust the position of the pretreatment assembly.

In one embodiment, the at least two pretreatment assemblies comprise a heating assembly, a homogenizing assembly and a magnetic separation assembly; or the at least two pretreatment assemblies comprise a heating and uniformly mixing assembly and a magnetic separation assembly.

A medical analysis system comprising said biological sample pretreatment device.

When one of the pretreatment assemblies is required to be used for pretreating a biological sample liquid carrier, the position of one of the pretreatment assemblies is adjusted through the movement of the moving assembly, so that the butt joint part of the pretreatment assembly moves onto the lifting part; then, the lifting part of the lifting component drives the butt joint part to move up and down, so that the pretreatment component can lift and contact with a biological sample liquid carrier, and the pretreatment component can carry out pretreatment operation on the biological sample liquid carrier; after the pretreatment is finished, the pretreatment module is separated from the biological sample liquid carrier by lowering the position of the pretreatment module through the lifting module, and the pretreatment module is moved away from the lifting module through the moving module, and the pretreatment operation can be carried out on other pretreatment modules in a similar manner. Therefore, the at least two pretreatment assemblies share the same lifting assembly, and each pretreatment assembly is not required to be provided with one lifting assembly, so that the structure of the biological sample pretreatment device can be greatly simplified, the volume of the biological sample pretreatment device is small, and the cost is low.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention.

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a perspective view of a biological sample pretreatment device according to an embodiment of the present invention;

FIG. 2 is a perspective view of a biological specimen pretreatment device according to an embodiment of the present invention with two pretreatment modules hidden;

FIG. 3 is a view of the biological specimen pretreatment device with the pretreatment module hidden according to an embodiment of the present invention;

FIG. 4 is a view structure diagram of the lifting assembly mounted on the vertical plate according to an embodiment of the present invention;

FIG. 5 is a view illustrating a structure of a biological sample pretreatment device according to another embodiment of the present invention;

FIG. 6 is a schematic structural view illustrating a heating element as a pretreatment assembly according to an embodiment of the present invention;

FIG. 7 is a schematic structural diagram of the pre-processing assembly of the embodiment of the present invention being an oscillating mixer assembly

Fig. 8 is a schematic structural diagram of the pretreatment module according to an embodiment of the present invention.

10. A moving assembly; 11. a sliding plate; 12. a first power mechanism; 121. a first motor; 122. a driven wheel; 123. a drive belt; 13. rotating the tray; 14. a third power mechanism; 15. a lifting guide assembly; 151. a vertical plate; 152. a second slide rail; 20. a pre-processing assembly; 21. a docking portion; 211. a roller; 22. a second slider; 23. a heating mechanism; 231. a heat conducting block; 2311. a first chamber; 2312. a second chamber; 232. a heating plate; 2321. a first conductive line; 233. a heat-insulating layer; 234. a first mounting plate; 2341. a guide portion; 2342. a recess; 2343. a first snap ring; 2344. a wiring hole; 2345. a boss; 235. an outer wall panel; 24. a first support plate; 241. a guide through hole; 2411. a protrusion; 25. a second elastic member; 26. a second temperature sensor; 261. a second conductive line; 271. an ultrasonic transducer; 272. a second mounting plate; 273. a second support plate; 274. a third elastic member; 275. a guide shaft; 281. a support column; 282. a permanent magnet; 283. a fourth elastic member; 284. a third support plate; 285. a second snap ring; 30. a lifting assembly; 31. a lifting part; 311. a chute; 32. a second power mechanism; 33. a fixing plate; 34. a guide rod; 40. a support; 41. a first slide rail; 42. a first slider; 43. a substrate; 44. a vertical plate; 51. a first sensor; 52. a second sensor; 53. a first trigger; 54. a third sensor; 55. a fourth sensor; 56. a second trigger; 61. a main shaft; 62. a shaft sleeve; 63. code disc; 631. a detection port; 64. a detection element; 65. rotating the tray; 70. a first elastic member.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Referring to fig. 1 to 4, fig. 1 shows a view structure of a biological sample pretreatment device according to an embodiment of the present invention, fig. 2 shows a view structure of a biological sample pretreatment device according to an embodiment of the present invention with two pretreatment modules 20 hidden, fig. 3 shows a view structure of a biological sample pretreatment device according to an embodiment of the present invention with two pretreatment modules 20 hidden, and fig. 4 shows a view structure of a lifting module 30 according to an embodiment of the present invention installed on a vertical plate 44. An embodiment of the present invention provides a biological sample pretreatment device, including: a moving assembly 10, at least two pre-processing assemblies 20, and a lifting assembly 30. At least two pretreatment modules 20 are arranged on the moving module 10 in a lifting way, and the pretreatment modules 20 are provided with butt joint parts 21. The lifting assembly 30 is provided with a lifting part 31 which is matched with the butt joint part 21. The moving assembly 10 is used for movably adjusting the positions of at least two pretreatment assemblies 20 so that the butt joint part 21 of one pretreatment assembly 20 moves to the lifting part 31. The lifting assembly 30 is used for driving the docking portion 21 to move up and down by the lifting portion 31, so that the pretreatment assembly 20 is lifted and lowered and contacts with a biological sample liquid carrier (not shown).

It should be noted that at least two pretreatment modules 20 can be used for different applications or the same application of the pretreatment modules 20, and the pretreatment modules 20 can be used for performing pretreatment steps such as cell lysis, DNA adsorption, magnetic separation, heating or mixing on the biological sample fluid when contacting with the biological sample fluid carrier. The number of the pretreatment modules 20 is, for example, two, three, four or other numbers, which are not limited herein, and is set according to actual requirements, and fig. 1 of the present embodiment shows that the pretreatment modules 20 are specifically three.

When the biological sample pretreatment device needs to use one of the pretreatment modules 20 to pretreat the biological sample liquid carrier, the moving module 10 moves to adjust the position of one of the pretreatment modules 20, so that the butt joint part 21 of the pretreatment module 20 moves to the lifting part 31; then, the lifting part 31 is lifted by the lifting component 30 to drive the butt joint part 21 to move up and down, so that the pretreatment component 20 can be lifted and contacted with a biological sample liquid carrier, and the pretreatment component 20 can be used for carrying out pretreatment operation on the biological sample liquid carrier; after the pretreatment is completed, the pretreatment module 20 is separated from the biological sample liquid carrier by lowering the position of the pretreatment module 20 by the lifting module 30, and the pretreatment module 20 is moved away from the lifting module 30 by the moving module 10, and the pretreatment operation can be performed on the other pretreatment modules 20 in a similar manner. Therefore, at least two pretreatment assemblies 20 share the same lifting assembly 30, and each pretreatment assembly 20 is not required to be provided with one lifting assembly 30, so that the structure of the biological sample pretreatment device can be greatly simplified, the volume of the biological sample pretreatment device is smaller, and the cost is low.

Referring to fig. 1 to 3, further, the biological sample pretreatment device further includes a holder 40. The moving assembly 10 includes a sliding plate 11 slidably disposed on the bracket 40, and a first power mechanism 12 disposed on the bracket 40. The first power mechanism 12 is used for driving the sliding plate 11 to slide on the bracket 40 to adjust the position of the sliding plate 11. At least two pre-treatment modules 20 are arranged elevatably on the slide plate 11. In this way, after the first power mechanism 12 drives the sliding plate 11 to slide on the bracket 40 to adjust the position of the sliding plate 11, the sliding plate 11 correspondingly moves synchronously to adjust the positions of at least two pretreatment modules 20.

It should be noted that the first power mechanism 12 mainly provides power to enable the sliding plate 11 to slide on the bracket 40, and the specific implementation manner is many, for example, the first power mechanism 12 includes a first motor 121 installed on the bracket 40, a driving wheel and a driven wheel 122 rotatably installed on the bracket 40, and a driving belt 123 connecting the driving wheel (not shown) and the driven wheel 122, the first motor 121 drives the driving wheel to rotate, the driving wheel drives the driven wheel 122 to rotate through the driving belt 123, one portion of the driving belt 123 is fixedly connected to the sliding plate 11 through a connecting member (not shown), and the driving belt 123 correspondingly drives the sliding plate 11 to slide along the bracket 40 synchronously through the connecting member when moving. For another example, the first power mechanism 12 may be a screw motor, a cylinder drive, an electric cylinder drive, a gear drive, or the like, which is not limited herein.

Referring to fig. 1 to 3, in an embodiment, a first slide rail 41 is disposed on the bracket 40, a first slide block 42 is disposed on the sliding plate 11, and the first slide block 42 is slidably disposed on the first slide rail 41. In this way, when the first power mechanism 12 drives the sliding plate 11 to move, the first sliding block 42 is implemented along the first sliding rail 41, and the first sliding rail 41 plays a better guiding role, so that the sliding plate 11 moves more stably. It should be understood that the sliding arrangement of the sliding plate 11 relative to the bracket 40 is not limited to the above-mentioned manner of matching the first sliding rail 41 with the first sliding block 42, but may also be, for example, a manner of matching a sliding sleeve with a guide shaft, or a manner of matching a guide shaft with a linear bearing, or other sliding matching manners, and is not limited herein.

Referring to fig. 1-3, in one embodiment, the lifting assembly 30 includes a second power mechanism 32 mounted on a bracket 40. The second power mechanism 32 is used for driving the lifting part 31 to move up and down. The second power mechanism 32 is similar to the first power mechanism 12, as long as it can drive the lifting unit 31 to move up and down, and the specific configuration is not limited herein and may be set according to actual situations.

Referring to fig. 1 and 4, in one embodiment, the biological sample pretreatment device further comprises a first sensing element disposed on the support 40. The first sensing assembly is used for sensing the operation position of the lifting part 31. Similarly, the biological sample pretreatment device further comprises a second sensing member disposed on the support 40, the second sensing member being used to sense the operation position of the sliding plate 11. So, first sensing component senses and lifts the operation position back of portion 31, the controller according to first sensing component's sensing signal alright with carrying out the position calibration to lifting unit 30, guarantee that lifting unit 30's lift position control is accurate. Similarly, after the second sensing assembly senses the operation position of the sliding plate 11, the controller can calibrate the position of the moving assembly 10 according to the sensing signal of the second sensing assembly, so as to ensure that the moving position of the moving assembly 10 is accurately controlled.

Referring to fig. 1 and 4, in detail, the first sensing assembly includes a first sensor 51 and a second sensor 52 disposed on the bracket 40 along the vertical direction, and a first trigger 53 disposed on the lifting portion 31. When the first trigger piece 53 moves to the position of the first sensor 51, the first sensor 51 is triggered to act, and when the first trigger piece 53 moves to the position of the second sensor 52, the second sensor 52 is triggered to act. Like this, can acquire the position that lifting unit 31 is located through first sensor 51 and second sensor 52, alright carry out position calibration to lifting unit 30, guarantee that lifting unit 30's lift position control is accurate.

More specifically, the first sensor 51 and the second sensor 52 are both, for example, opto-coupler sensors, the first trigger 53 is a baffle capable of cutting off an opto-coupler signal of the opto-coupler sensors, when the baffle moves to the position of the first sensor 51, the baffle can cut off the opto-coupler signal of the first sensor 51, the first sensor 51 can correspondingly judge that the lifting part 31 moves in place, and at this time, the position of the lifting part 31 is, for example, an initial position; when the baffle moves to the position of the second sensor 52, the baffle can cut off the optical coupling signal of the second sensor 52, and the second sensor 52 can correspondingly judge that the lifting part 31 moves to the right position, at this moment, the position of the lifting part 31 is, for example, the end position.

As an alternative, the first sensor 51 and the second sensor 52 may also be, for example, proximity switches, the first trigger 53 is a sensing element capable of sensing by cooperating with the proximity switches, when the sensing element moves close to the position of the first sensor 51, the sensing element can be sensed by the first sensor 51, and the first sensor 51 correspondingly determines that the lifting portion 31 moves to the position, where the position of the first mounting plate 234 is, for example, an initial position; when the sensing member moves to a position close to the second sensor 52, the second sensor 52 can sense the position, and the second sensor 52 correspondingly determines that the lifting portion 31 moves to the proper position, where the position of the lifting portion 31 is, for example, an end position.

Similarly, the second sensing assembly includes a third sensor 54 and a fourth sensor 55 provided on the bracket 40 in the lateral direction, and a second trigger 56 provided on the sliding plate 11. When the second trigger member 56 moves to the position of the third sensor 54, the third sensor 54 is triggered to act, and when the second trigger member 56 moves to the position of the fourth sensor 55, the fourth sensor 55 is triggered to act. In this way, the position of the sliding plate 11 can be obtained through the third sensor 54 and the fourth sensor 55, so that the position of the moving assembly 10 can be calibrated, and the moving position of the moving assembly 10 is accurately controlled.

Referring to fig. 2 and 3, in particular, the bracket 40 includes a base plate 43 and a vertical plate 44 connected to the base plate 43. The slide plate 11 is slidably disposed on the base plate 43. The lift assembly 30 is mounted on the vertical plate 44. More specifically, the lifting portion 31 is slidably disposed on the vertical plate 44, so that the second power mechanism 32 can operate stably and reliably under the pushing action. The sliding arrangement of the lifting portion 31 on the vertical plate 44 can refer to the sliding arrangement of the sliding plate 11 on the bracket 40, for example, the lifting assembly 30 further includes a fixed plate 33 mounted on the vertical plate 44 and a guide rod 34 mounted on the fixed plate 33, and the lifting portion 31 is slidably disposed on the guide rod 34 by way of a sliding hole, a linear bearing or a sliding sleeve, for example. Specifically, the number of the fixing plates 33 is two, two fixing plates 33 are disposed at an interval, two ends of the guide rod 34 are connected to the two fixing plates 33, respectively, and the number of the guide rods 34 is one, two, three, or the other, for example.

Referring to fig. 5, fig. 5 is a view illustrating a structure of a biological sample pretreatment device according to another embodiment of the present invention. In one embodiment, the biological sample pretreatment device further comprises a main shaft 61 and a sleeve 62 rotatably sleeved on the main shaft 61. The moving assembly 10 includes a rotating tray 6513 fixedly disposed on the shaft sleeve 62, and a third power mechanism 14 for driving the rotating tray 6513 to rotate. At least two pre-processing assemblies 20 are elevationally disposed on the rotating tray 6513. The lifting assembly 30 is mounted on the main shaft 61 or an external frame. Thus, after the third power mechanism 14 drives the rotating tray 6513 to rotate and adjust the position of the rotating tray 6513, the rotating tray 6513 correspondingly and synchronously rotates and adjusts the positions of the at least two pretreatment modules 20, so that the butt joint part 21 of the at least two pretreatment modules 20 can sequentially rotate to the position butted with the lifting part 31 of the lifting module 30, and the lifting module 30 can sequentially drive the at least two pretreatment modules 20 to lift so as to sequentially perform pretreatment operation on the biological sample liquid carrier.

Specifically, the sleeve 62 is rotatably provided on the main shaft 61 through a bearing. In addition, the third power mechanism 14 is connected to the sleeve 62 through a pulley transmission, a sprocket transmission, a gear transmission, and the like, and drives the sleeve 62 to rotate, so as to drive the rotating tray 6513 to rotate.

Referring to fig. 5, in one embodiment, the biological sample pretreatment device further includes a code wheel 63 fixedly disposed on the hub 62, and a detection element 64 for being disposed on the external housing. The code wheel 63 is provided with a detection port 631, and when the detection port 631 is sensed by the detection element 64, the rotational position of the code wheel 63 can be acquired. In this way, the detection element 64 senses the detection port 631 to obtain the rotation position of the code wheel 63, so that the position calibration of the moving assembly 10 can be performed, and the moving position control accuracy of the moving assembly 10 is ensured. Specifically, the detection element 64 is, for example, a photoelectric switch, a proximity switch, or the like, and is not limited herein.

Referring to fig. 5, in one embodiment, at least two detection ports 631 are provided, at least two detection ports 631 are sequentially and alternately disposed on the code wheel 63, and at least two detection ports 631 are disposed in one-to-one correspondence with at least two preprocessing modules 20. When the detection port 631 of the code wheel 63 rotates to the position corresponding to the detection element 64, it indicates that the preprocessing component 20 corresponding to the detection port 631 moves to the position where it is butted against the lifting component 30, the butting portion 21 of the preprocessing component 20 is matched with the lifting portion 31 of the lifting component 30, and the third power mechanism 14 is controlled to stop driving accordingly, and the lifting component 30 performs the lifting operation.

Referring to fig. 1 or 5, in one embodiment, the biological sample pretreatment device further includes a lifting guide assembly 15 mounted on the moving assembly 10. The number of the lifting guide assemblies 15 is at least two, and the at least two lifting guide assemblies 15 are arranged in one-to-one correspondence with the at least two pretreatment assemblies 20. The pre-processing assembly 20 is slidably disposed on the elevation guide assembly 15. Therefore, under the lifting guide effect of the lifting guide assembly 15 on the pretreatment assembly 20, the lifting operation process of the pretreatment assembly 20 driven by the lifting assembly 30 is stable. Specifically, the lifting guide assembly 15 includes a vertical plate 151 mounted on the sliding plate 11, and a second slide rail 152 mounted on the vertical plate 151, and correspondingly, the pretreatment assembly 20 is further provided with a second slide block 22 slidably disposed on the second slide rail 152.

Referring again to fig. 1, in one embodiment, the biological sample pretreatment device further comprises at least two first elastic members 70. The at least two first elastic members 70 are disposed in one-to-one correspondence with the at least two preprocessing assemblies 20, and the preprocessing assemblies 20 are connected with the moving assembly 10 through the corresponding first elastic members 70. The first elastic member 70 is, for example, a tension spring or an elastic strip. The first elastic member 70 enables the pre-processing assembly 20 to be normally located at the bottommost position of the lifting guide assembly 15 with a certain pressure, so that the moving assembly 10 operates stably and reliably during the process of moving the pre-processing assembly 20.

Referring to fig. 1, 2 and 5, in one embodiment, the abutting portion 21 is provided with a roller 211, and the lifting portion 31 is provided with a sliding slot 311 capable of accommodating the roller 211. The moving assembly 10 can move the roller 211 of the pre-treating assembly 20 into or out of the sliding slot 311 when the pre-treating assembly 20 is adjusted in position. In this way, the moving assembly 10 can move the roller 211 of the pretreatment unit 20 into or out of the sliding slot 311 smoothly when the pretreatment unit 20 is adjusted.

Further, the at least two pretreatment modules 20 comprise a heating module, a uniform mixing module and a magnetic separation module; alternatively, the at least two pre-treatment assemblies 20 include a thermal tempering assembly and a magnetic separation assembly.

It should be noted that the heating element serves as a pre-treatment for heating the biological sample fluid when it is in contact with the biological sample fluid carrier. The blending component is used for performing a pretreatment operation of blending the biological sample liquid when the biological sample liquid is contacted with the biological sample liquid carrier. The magnetic separation module is used for performing a pretreatment operation of magnetic separation on biological sample fluid when the magnetic separation module is in contact with the biological sample fluid carrier. The heating and blending component is a component when the heating component and the blending component are combined together, and has the functions of both the heating component and the blending component, namely the pretreatment operation of heating and/or blending the biological sample liquid when the biological sample liquid contacts with the biological sample liquid carrier.

Referring to fig. 1 again, in one embodiment, a medical analysis system includes any one of the above embodiments of the biological sample pretreatment device.

When one of the pretreatment modules 20 is needed to be used for pretreatment of the biological sample liquid carrier, the mobile module 10 moves to adjust the position of one of the pretreatment modules 20, so that the butt-joint part 21 of the pretreatment module 20 moves to the lifting part 31; then, the lifting part 31 is lifted by the lifting component 30 to drive the butt joint part 21 to move up and down, so that the pretreatment component 20 can be lifted and contacted with a biological sample liquid carrier, and the pretreatment component 20 can be used for carrying out pretreatment operation on the biological sample liquid carrier; after the pretreatment is completed, the pretreatment module 20 is separated from the biological sample liquid carrier by lowering the position of the pretreatment module 20 by the lifting module 30, and the pretreatment module 20 is moved away from the lifting module 30 by the moving module 10, and the pretreatment operation can be performed on the other pretreatment modules 20 in a similar manner. Therefore, at least two pretreatment assemblies 20 share the same lifting assembly 30, and each pretreatment assembly 20 is not required to be provided with one lifting assembly 30, so that the structure of the biological sample pretreatment device can be greatly simplified, and the biological sample pretreatment device has the advantages of small volume and low cost.

As an example, referring to fig. 6 to 8 again, fig. 6 is a schematic structural diagram illustrating the pretreatment module 20 as a heating module according to an embodiment of the present invention; FIG. 7 is a schematic diagram of the pre-processing assembly 20 as an oscillating blending assembly according to an embodiment of the present invention; fig. 8 shows a schematic structure of the pretreatment module 20 according to an embodiment of the present invention. The pre-treatment assembly 20 is, for example, a heating assembly, an oscillating homogenisation assembly, a magnetic separation assembly, or the like.

Referring to fig. 6, the heating assembly includes a heating mechanism 23 and a circuit board. The heating mechanism 23 includes a heat conducting block 231, a heating sheet 232, and an insulating layer 233. The top end surface of the heat conducting block 231 is used for abutting against the bottom surface of the biological sample liquid carrier, so that heat can be transferred to the biological sample liquid carrier. The heating plate 232 is disposed around and attached to the outer wall of the heat conducting block 231. The insulating layer 233 surrounds and is attached to the outer wall of the heating sheet 232. The heat patch 232 is electrically connected to the circuit board through the first lead 2321. Therefore, when the heating assembly works, the circuit board controls the heating sheet 232 to work, the heating sheet 232 generates heat and conducts the heat to the heat conducting block 231, and the top end surface of the heat conducting block 231 can transmit the received heat to the biological sample liquid carrier when contacting the bottom surface of the biological sample liquid carrier, so that the temperature of the biological sample reaction liquid in the biological sample liquid carrier is increased, and the incubation treatment can be carried out on the biological sample reaction liquid in the biological sample liquid carrier. Wherein, heat preservation 233 can avoid the temperature of heating plate 232 to diffuse outward, plays better heat preservation effect for heating plate 232 transmits the heat for the majority to heat conduction piece 231, has better heating effect to biological sample liquid carrier. In addition, the structure of the heating assembly formed by the heat conducting block 231, the heating sheet 232 and the heat insulating layer 233 is simple, the arrangement is reasonable, and the volume size is small.

It should be noted that the heat conducting block 231 is specifically made of a material with a good heat conducting property, which is beneficial to better conducting heat to the biological sample liquid carrier, and the heat conducting block 231 is specifically made of a metal material such as copper, aluminum, or iron, and may be made of other non-metal heat conducting materials, which is not limited herein.

In addition, the specific shape and size of the heat conducting block 231 can be adjusted according to the external shape and size of the bottom surface of the biological sample liquid carrier. As an example, the heat conducting block 231 is a cylinder, the top end surface of the cylinder is adapted to the bottom surface of the biological sample liquid carrier, and the heating plate 232 is disposed around the outer circumference of the cylinder. Alternatively, the heat conducting block 231 may have other shapes as long as it can better transfer heat to the bottom surface of the biological sample liquid carrier, and the specific shape and size are not limited herein and are set according to actual conditions.

Referring to fig. 6, further, the heating plate 232 is fixed on the outer wall of the heat conducting block 231 by a heat conducting glue. So, the heating plate 232 can be installed comparatively firmly on the outer wall of heat conduction piece 231, and the heating plate 232 can give the heat conduction piece 231 with the heat through heat conduction gluey transmission. In addition, since the heating plate 232 is directly adhered to the outer wall of the heat conducting block 231, the installation operation on the heat conducting block 231 is convenient and fast. Specifically, the heat conductive adhesive is, for example, a heat conductive adhesive backing, and may be another type of heat conductive adhesive, which is not limited herein.

It should be noted that the heating plate 232 may also be fixedly mounted on the outer wall of the heat conducting block 231 by other mounting methods, which are not limited herein, for example, the mounting method may be implemented by using mounting pieces such as screws, rivets, bolts, and pins, or may be directly welded or clamped, and the like, and the mounting method may be set according to actual requirements.

Referring to fig. 6, further, the insulation layer 233 is insulation cotton disposed around the outer wall of the heating sheet 232. Therefore, the heat preservation cotton can play a better role in heat preservation and heat insulation. The heat preservation cotton specifically adopts high temperature resistant cotton material to can guarantee the security performance. The insulating layer 233 is not limited to insulating cotton, and may be other forms of insulating members as long as they can perform the functions of heat preservation and heat insulation, and is not limited herein.

Referring to fig. 6, in one embodiment, the insulation wool is adhesively secured to the outer wall of the heater chip 232 by adhesive. So, the heating plate 232 can be installed comparatively firmly on the outer wall of heating plate 232, owing to directly adopt the mode of bonding to set up in the outer wall of heating plate 232, the installation operation of heat preservation cotton on heating plate 232 is comparatively convenient and fast. The glue is for example a back glue or another type of glue. The insulation wool may be fixed on the outer wall of the heating sheet 232 by other methods, for example, the above-mentioned fixing method may be implemented by using a fixing member such as a screw, a rivet, a bolt, a pin, or the like, or may be directly welded or clamped, and the like, which is not limited herein.

Referring to fig. 6, in one embodiment, the heating assembly further includes an outer wall plate 235. The outer wall plate 235 surrounds and is attached to the outer wall of the heat insulation cotton. So, the out wall board 235 plays the fixed action to the heat preservation cotton, can avoid the heat preservation cotton to loosen and drop. In addition, the hardness of outer wallboard 235 is enough, plays the guard action to the heat preservation cotton, can avoid the heat preservation cotton damage to appear. Optionally, the outer wall panel 235 is an insulated panel. So, the outer wall plate 235 can reduce the heat outward transmission of heat conduction piece 231 to reduce calorific loss, had better heat preservation effect.

Referring to fig. 6, further, the heating mechanism 23 further includes a first mounting plate 234. The heat conducting block 231 and the outer wall plate 235 are fixed on the first mounting plate 234. Thus, by fixing the heat conducting block 231 and the outer wall plate 235 to the first mounting plate 234, the overall structure of the heating mechanism 23 formed by the combination is more stable and reliable. Further, similar to the outer wall plate 235, the first mounting plate 234 may be made of, for example, a heat insulating plate, which has a good heat insulating effect, so as to reduce the heat leakage of the heat conducting block 231.

Referring to fig. 6, in one embodiment, the heating assembly further includes a first support plate 24 and a second elastic member 25 positioned between the first mounting plate 234 and the first support plate 24. The heating mechanism 23 is connected to the first support plate 24 via the second elastic member 25. Thus, when the first supporting plate 24 drives the heating mechanism 23 to move from bottom to top to contact the bottom surface of the biological sample liquid carrier, since the bottom surface of the biological sample liquid carrier is in an immobile state, the heating mechanism 23 can extrude the second elastic member 25 when contacting the bottom surface of the biological sample liquid carrier, so that the bottom surface of the biological sample liquid carrier can be adaptively adjusted, matched and attached tightly, and then the bottom surface of the biological sample liquid carrier can be heated, incubated and processed. The abutting portion 21 and the second slider 22 are mounted on the first support plate 24.

Referring to fig. 6, in one embodiment, the first mounting plate 234 has a guide 2341 on the plate surface. The first support plate 24 is provided with guide through holes 241 corresponding to the positions of the guide portions 2341. The guide portion 2341 is vertically movably disposed in the guide through hole 241. The second elastic member 25 is a spring, the spring is sleeved outside the guiding portion 2341, and two ends of the spring respectively abut against the first mounting plate 234 and the first supporting plate 24. In addition, the second elastic member 25 may also be an elastic block or the like, and is not limited herein.

Referring to fig. 6, further, a concave portion 2342 is arranged on the plate surface of the first mounting plate 234 and surrounds the guide portion 2341, one end of the spring is arranged in the concave portion 2342, and the concave portion 2342 has a limiting effect on the end portion of the spring, so that the operation stability of the spring in the compression process can be guaranteed; the pore wall of direction through-hole 241 is equipped with arch 2411, and the other end of spring stretches into in the direction through-hole 241 and inconsistent with arch 2411, and the other end of spring is spacing in direction through-hole 241, can guarantee the operating stability of spring in compression process. In addition, the guide part 2341 penetrates through the guide through hole 241, the first clamping ring 2343 is arranged on the guide part 2341, and the first clamping ring 2343 abuts against the side face, away from the first mounting plate 234, of the first support plate 24.

Referring to fig. 6, in one embodiment, the heating element further includes a first temperature sensor (not shown) and a second temperature sensor 26. The first temperature sensor is disposed on the heating plate 232, and the first temperature sensor is configured to obtain a first temperature of the heating plate 232. The second temperature sensor 26 is disposed on the heat-conducting block 231, and the second temperature sensor 26 is configured to obtain a second temperature of the heat-conducting block 231. Therefore, on one hand, the temperature of the heating sheet 232 can be grasped according to the first temperature obtained by the first temperature sensor, and the working power of the heating sheet 232 can be correspondingly and timely controlled; on the other hand, the temperature of the heat conduction block 231 can be grasped according to the second temperature obtained by the second temperature sensor 26, the heating incubation temperature can be accurately controlled, and the heating sheet 232 is correspondingly controlled to stop working when the temperature of the heat conduction block 231 is judged to exceed the preset temperature; in addition, the first temperature and the second temperature can be compared, and when the deviation between the first temperature and the second temperature is large, the fault of one temperature sensor can be correspondingly judged.

Referring to fig. 6, the heat conducting block 231 has a first chamber 2311 and a second chamber 2312 which are communicated with each other. The second temperature sensor 26 is installed in the first chamber 2311. First mounting plate 234 is equipped with the wire hole 2344 that is linked together with second chamber 2312, and second temperature sensor 26's second wire 261 is in proper order through second chamber 2312 and wire hole 2344 and draws forth the outside back and the circuit board electric connection of heat-conducting block 231. First cavity 2311 suits with second temperature sensor 26, and the temperature of heat conduction piece 231 can accurately be obtained when second temperature sensor 26 laminates in first cavity 2311 inner wall. The volume size of the second cavity 2312 is larger than that of the first cavity 2311, so that when the second conducting wire 261 is led out through the second cavity 2312, the second conducting wire 261 cannot contact with the inner wall of the second cavity 2312, and the second conducting wire 261 cannot be burnt and damaged.

Referring to fig. 6, further, a protruding platform 2345 is disposed on the plate surface of the first mounting plate 234, the protruding platform 2345 is adapted to the opening of the second chamber 2312 and extends into the opening of the second chamber 2312, and the protruding platform 2345 of the first mounting plate 234 limits the heat conducting block 231.

In addition, specifically, the first conductive wires 2321 are electrically connected to the circuit board through the flexible flat cable, and similarly, the second conductive wires 261 are also electrically connected to the circuit board through the flexible flat cable. The position of the circuit board is usually fixed, and the first supporting plate 24 needs to drive the heating mechanism 23 to move up and down to approach and contact the bottom surface of the biological sample liquid carrier, for example, in the process of ascending or descending of the heating mechanism 23, the flexible flat cable can move in the vertical direction independently like a drag chain, the movement effect is smooth, so that the drag chain can be omitted, and the structure is compact and simple.

Referring to fig. 7, the oscillating and mixing assembly includes an ultrasonic transducer 271, a second mounting plate 272 and a second support plate 273. The ultrasonic transducer 271 is fixedly arranged on the second mounting plate 272, and the head of the ultrasonic transducer 271 is used for contacting or connecting with the bottom surface of the biological sample liquid carrier. The second support plate 273 and the second mounting plate 272 are spaced apart from each other, and the second mounting plate 272 is mounted on the second support plate 273 by a third elastic member 274. Specifically, the abutting portion 21 and the second slider 22 are provided on the second support plate 273. When the biological sample reaction solution needs to be oscillated and mixed uniformly, for example, the oscillating and mixing assembly moves from bottom to top and contacts with the bottom surface of the carrier, and as the oscillating and mixing assembly continues to move, the third elastic member 274 starts to compress, and the ultrasonic transducer 271 is tightly attached to the bottom of the carrier. Ultrasonic transducer 271 begins work this moment, because ultrasonic transducer 271 links to each other with second backup pad 273 through third elastic component 274, is the flexible contact with the contact of the bottom surface of carrier promptly, has avoided ultrasonic transducer 271 in the bottom rough and violent work of carrier to avoid reaction liquid to splash everywhere in the carrier, destroy the mixing effect, can also effectively promote the mixing effect. From the outside, power and ultrasonic frequency that ultrasonic transducer 271 outputted can freely be adjusted, guarantee that reaction solution thoroughly mixes. In addition, when the biological sample needs cell lysis, the output power and frequency of the ultrasonic transducer 271 are adjusted to be increased, and when the power and frequency are increased to a certain degree, the cells are lysed.

Further, a first positioning hole is formed in the plate surface of the second mounting plate 272, and a second positioning hole corresponding to the first positioning hole is formed in the second supporting plate 273. One end of the third elastic member 274 is disposed in the first positioning hole, and the other end of the third elastic member 274 is disposed in the second positioning hole. Therefore, the two ends of the third elastic member 274 are respectively arranged in the first positioning hole and the second positioning hole, and in the working process, the third elastic member 274 cannot be easily moved out of the first positioning hole and the second positioning hole, so that the third elastic member 274 is well positioned, and the oscillation and uniform mixing assembly can work normally.

Referring to fig. 7, in one embodiment, the number of the third elastic elements 274 is two or more, and the number of the first positioning holes and the number of the second positioning holes are two or more; the two or more first positioning holes and the two or more second positioning holes are disposed in one-to-one correspondence with the two or more third elastic members 274. Specifically, the number of the third elastic members 274 is, for example, one, two, three, four or other numbers, and the number of the first positioning holes and the number of the second positioning holes are respectively, one, two, three, four or other numbers. In this embodiment, the number of the third elastic members 274 illustrated in the drawings is specifically four, the number of the first positioning holes and the number of the second positioning holes are four, and the four third elastic members 274 are disposed between the second mounting plate 272 and the second support plate 273 at intervals.

Referring to fig. 7, in one embodiment, the oscillating blending assembly further includes a guide shaft 275. The outer wall of one end of the guide shaft 275 is provided with a first flange, the first flange is abutted to the plate surface of the second mounting plate 273 away from the second mounting plate 272, and the guide shaft 275 penetrates through the first positioning hole and can move along the first positioning hole. In addition, a second flange is wound around the outer wall of the other end of the guide shaft 275, the second flange abuts against the surface of the second support plate 273, which is far away from the second mounting plate 272, and the guide shaft 275 penetrates through the second positioning hole and can move along the second positioning hole. Therefore, the ultrasonic transducer 271 drives the second mounting plate 272 to move during operation, and the second mounting plate 272 vibrates vertically under the guiding action of the guide shaft 275. Further, the second mounting plate 272 and the ultrasonic transducer 271 are movable in the region between the first flange and the second flange.

Referring to fig. 7, in one embodiment, the third elastic member 274 is a spring, and the spring is sleeved outside the guide shaft 275, and two ends of the spring are respectively in contact with the second support plate 273 and the second mounting plate 272. Specifically, the third elastic member 274 is, for example, a round wire coil spring. In addition, the outer diameter of the guide shaft 275 is smaller than the inner diameter of the round wire coil spring, so that the guide shaft 275 and the round wire coil spring can be prevented from colliding with each other during operation. The third elastic member 274 is not limited to a spring, and may be, for example, an elastic block having both ends in contact with the second support plate 273 and the second mounting plate 272, but the third elastic member 274 may be fixed to the second support plate 273 and the second mounting plate 272, without being limited thereto, and may be provided in accordance with actual circumstances.

Referring to fig. 8, the magnetic separating unit includes a supporting pole 281, a permanent magnet 282 disposed on the supporting pole 281, a fourth elastic member 283 and a third supporting plate 284. Specifically, the permanent magnet 282 is disposed within the support column 281. In addition, the permanent magnet 282 and the supporting column 281 may be shaped to match the bottom shape of the biological sample liquid carrier, for example, both may be designed as a cylinder. The permanent magnets 282 can generate strong magnetic field, and the number of the permanent magnets 282 in the supporting column 281 can be determined according to the intensity of the magnetic field. Specifically, the abutting portion 21 and the second slider 22 are provided on the third support plate 284.

Further, the supporting post 281 is connected to the third supporting plate 284 by a fourth elastic member 283, and an end portion of the supporting post 281 penetrates the third supporting plate 284 and is prevented from being detached from the third supporting plate 284 by a second snap ring 285. Thus, when the permanent magnet 282 is matched with the biological sample liquid carrier from bottom to top, the self-adaptive adjustment can be realized, the bottom of the carrier can be well attached, and the attachment force can be well controlled. The fourth elastic member 283 may be one or more, and specifically, one fourth elastic member 283 is illustrated in the embodiment.

All possible combinations of the technical features in the above embodiments may not be described for the sake of brevity, but should be considered as being within the scope of the present disclosure as long as there is no contradiction between the combinations of the technical features.

The above examples only show several embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, but are not intended to indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise explicitly stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly, e.g., as being permanently connected, detachably connected, or integral; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are for purposes of illustration only and do not denote a single embodiment.

Claims (13)

1. A biological sample pretreatment device, comprising:

the device comprises a moving assembly and at least two pretreatment assemblies, wherein the at least two pretreatment assemblies are arranged on the moving assembly in a lifting manner and are provided with butt joint parts; and

lifting unit, lifting unit be equipped with butt joint portion matched with lift portion, it is used for removing the adjustment at least two to remove the subassembly remove the position of preliminary treatment subassembly, so that one of them preliminary treatment subassembly's butt joint portion removes lift portion is last, lifting unit is used for through going up and down lift portion drives butt joint portion lift action, so that preliminary treatment subassembly goes up and down and contacts with biological sample liquid carrier.

2. The biological sample pretreatment device of claim 1, further comprising a scaffold; the moving component comprises a sliding plate which is arranged on the bracket in a sliding way and a first power mechanism which is arranged on the bracket; the first power mechanism is used for driving the sliding plate to slide on the bracket so as to adjust the position of the sliding plate; at least two pretreatment assemblies are arranged on the sliding plate in a liftable mode.

3. The device as claimed in claim 2, wherein the rack has a first slide rail, the sliding plate has a first slide block, and the first slide block is slidably disposed on the first slide rail.

4. The apparatus of claim 2, wherein the lifting assembly comprises a second power mechanism mounted on the frame, the second power mechanism configured to drive the lifting member to move up and down.

5. The device of claim 2, further comprising a first sensing assembly disposed on the support for sensing an operating position of the lift; the biological sample pretreatment device also comprises a second sensing component arranged on the bracket, and the second sensing component is used for sensing the running position of the sliding plate.

6. The device of claim 1, further comprising a main shaft, a sleeve rotatably disposed on the main shaft; the moving assembly comprises a rotating tray fixedly arranged on the shaft sleeve and a third power mechanism for driving the rotating tray to rotate; at least two pretreatment assemblies are arranged on the rotary tray in a liftable manner; the lifting component is arranged on the main shaft or the external frame.

7. The device of claim 6, further comprising a code wheel fixedly disposed on the hub, and a detection element for disposing on an external housing; the coded disc is provided with a detection port, and the detection element can acquire the rotating position of the coded disc when sensing the detection port.

8. The pretreatment device for biological samples according to claim 7, wherein the number of the detection ports is at least two, at least two of the detection ports are sequentially arranged on the code disc at intervals, and at least two of the detection ports are arranged in one-to-one correspondence with at least two of the pretreatment modules.

9. The apparatus of any one of claims 1 to 8, further comprising a lifting guide member mounted on the moving member; the number of the lifting guide assemblies is at least two, and the at least two lifting guide assemblies are arranged in one-to-one correspondence with the at least two pretreatment assemblies; the pretreatment assembly is slidably arranged on the lifting guide assembly.

10. The biological sample pretreatment device of claim 9, further comprising at least two first elastic members; the at least two first elastic pieces and the at least two preprocessing assemblies are arranged in a one-to-one correspondence mode, and the preprocessing assemblies are connected with the moving assemblies through the corresponding first elastic pieces.

11. The apparatus of any one of claims 1 to 8, wherein the docking portion is provided with a roller, the lifting portion is provided with a sliding slot capable of accommodating the roller, and the moving member moves to adjust the position of the pre-processing assembly so as to move the roller of the pre-processing assembly into or out of the sliding slot.

12. The biological sample pretreatment device according to any one of claims 1 to 8, wherein the at least two pretreatment modules comprise a heating module, a homogenizing module, and a magnetic separation module; or the at least two pretreatment assemblies comprise a heating and uniformly mixing assembly and a magnetic separation assembly.

13. A medical analysis system, characterized in that it comprises a biological sample pretreatment device according to any of claims 1 to 12.

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