CN115369030B

CN115369030B - Stem cell extractor

Info

Publication number: CN115369030B
Application number: CN202211307573.XA
Authority: CN
Inventors: 曹丽平
Original assignee: Shenzhen Xinyilun Biotechnology Co ltd
Current assignee: Shenzhen Xinyilun Biotechnology Co ltd
Priority date: 2022-10-25
Filing date: 2022-10-25
Publication date: 2023-01-10
Anticipated expiration: 2042-10-25
Also published as: CN115369030A

Abstract

The invention relates to a stem cell extractor, which belongs to the technical field of cell collection and comprises an umbilical cord blood collection device and a blood storage unit, wherein the umbilical cord blood collection device comprises a lower support unit and an upper collection unit, the lower support unit and the upper collection unit are detachably connected, a placement area for placing an umbilical cord is formed between the lower support unit and the upper collection unit, the placement area is divided into an expansion area and two pressure areas respectively positioned at two ends of the expansion area along the extension direction, the volume of the expansion area is larger than that of the pressure areas, the joint between the expansion area and the pressure areas is rounded, a negative pressure area communicated with the expansion area is arranged in the upper collection unit, the umbilical cord in the expansion area is expanded through negative pressure in the negative pressure area, and the umbilical cord forms a bulge at the communication position of the negative pressure area and the expansion area.

Description

Stem cell extractor

Technical Field

The invention relates to the technical field of medical instruments, in particular to the technical field of cell collection, and particularly relates to a stem cell extractor.

Background

There are three ways of extracting hematopoietic stem cells: bone marrow extraction, peripheral blood extraction and cord blood extraction, the cord blood stem cells have the advantages of easy acquisition, low requirement on HLA match type, higher stem cell dryness, lower risk of graft-versus-host disease after transplantation and the like, and the first step of extracting the hematopoietic stem cells from the cord blood is to collect the cord blood from the cord.

The umbilical cord blood should be collected as soon as possible after the newborn baby is delivered, and the umbilical cord blood collection process is as follows: clipping the umbilical cord at the position of 10-15 cm of the end of a newborn, quickly cleaning the umbilical cord from the broken umbilical cord end to the placenta direction by using sterile gauze, sterilizing the umbilical cord by using iodophor, selecting a position with a sterilized and relatively straight placenta far end for puncture by a collection needle, enabling the inclined plane of the needle point to face downwards to be less than ten degrees, and fixing the needle head for blood collection after the needle head punctures 1-2 cm.

When a newborn baby is delivered from a mother body, the surface of an umbilical cord is smooth, and a lubricating liquid such as amniotic fluid is stained on the umbilical cord, in the delivery process of the newborn baby, the amniotic fluid has the effects of lubricating a vagina and assisting in guiding the birth of the newborn baby, the lubricating degree of the amniotic fluid is close to soap water, and the smoothness of the surface of the umbilical cord is increased, so that the umbilical cord needs to be cleaned quickly by using a sterile gauze in the collection process, the umbilical cord blood collection is generally finished within a short few minutes after the birth of the newborn baby and is a chance for a baby to have one time for a life, so that the umbilical cord cannot be cleaned completely by using the sterile gauze in a short time, in the subsequent collection needle puncture process, the amniotic fluid remaining on the umbilical cord and the smooth surface of the umbilical cord are easy to slip, and the hands of medical care personnel are generally worn with medical gloves, and the gloves are stained with the amniotic fluid when the baby takes on, so that the umbilical cord slips easily when the needle is held.

The whole umbilical cord is spirally distributed, but the cross section of the umbilical cord is generally flat, as shown in a in fig. 15 in the present application, so in the above collection process, the needle tip slope of the collection needle is downward less than ten degrees so as to avoid puncturing the umbilical cord, but as is well known, the smaller the inclination angle of the collection needle is, the closer it is to being parallel to the umbilical cord, the more the umbilical cord can be prevented from being punctured, but slippage is more likely to occur during puncturing the umbilical cord, and the larger the inclination angle of the collection needle is, the closer it is to being perpendicular to the umbilical cord, slippage is less likely to occur during puncturing the needle, but the umbilical cord is easier to be punctured during puncturing the needle, that is, slippage is less likely to occur during puncturing the collection needle, and puncturing the umbilical cord is difficult to be avoided.

Disclosure of Invention

To solve the problems mentioned in the background above, the present invention provides a stem cell extractor.

In order to achieve the technical purpose, the technical scheme adopted by the invention is as follows.

The utility model provides a stem cell extractor, including umbilical cord blood collection system and blood storage unit, umbilical cord blood collection system includes lower support unit and last collection unit, detachable connection and constitute one between the two between lower support unit and the last collection unit and be used for laying the district of laying the umbilical cord, it is distinguished with two pressure that are located the district both ends of bulging respectively to lay to divide into the district of bulging along the extending direction, the volume in bulging district is greater than the volume in pressure district and junction radius angle between the two, upward be provided with the negative pressure zone with bulging district's intercommunication in the collection unit, negative pressure through the negative pressure in the negative pressure zone makes the umbilical cord that is located the bulging district bloated and the umbilical cord form the swell in the negative pressure zone and the intercommunication department in bulging district.

Further, the lower supporting unit comprises an underframe and chucks, the chucks are used for clamping umbilical cords, a bearing platform which is horizontally arranged is installed at the upper end of the underframe, the bearing platform consists of a main bearing platform and side bearing platforms, the side bearing platforms are provided with two groups and are respectively located at two ends of the main bearing platform, a main bearing groove which runs through the main bearing platform in length is arranged on the upper end face of the main bearing platform, a side bearing groove which runs through the side bearing platform in length is arranged on the upper end face of the side bearing platform, the main bearing groove and the side bearing groove are communicated with each other and communicated with each other to form a fillet, and a slot which runs through the height of the main bearing platform is further arranged on the upper end face of the side bearing platform.

Furthermore, the upper collecting unit comprises a pressing table, the pressing table comprises a main pressing table and side pressing tables, the side pressing tables are provided with two groups and are respectively located at two ends of the main pressing table, a cover shell is arranged on the upper end face of the main pressing table, a main pressing groove penetrating through the length of the main pressing table is arranged on the lower end face of the main pressing table, a side pressing groove penetrating through the length of the side pressing table is arranged on the lower end face of the side pressing table, the side pressing groove and the main pressing groove are communicated with each other and are provided with a fillet at the communicating part, an inserting rod is further arranged on the lower end face of the side pressing table, and the inserting rod is correspondingly matched with an inserting groove formed in the upper end face of the side bearing table.

Furthermore, a magnetic strip groove is formed in the upper end face of the main bearing platform, a magnetic strip is installed in the magnetic strip groove, the upper end face of the magnetic strip is flush with the upper end face of the main bearing platform, an electromagnetic groove is formed in the lower end face of the main pressing platform, an electromagnet is arranged in the electromagnetic groove, the lower end face of the electromagnet is flush with the lower end face of the main pressing platform, the electromagnet is correspondingly matched with the magnetic strip arranged on the main bearing platform, magnetic adsorption force is generated between the electromagnet and the magnetic strip when the electromagnet is powered on, the pressing platform and the bearing platform are connected in an inserting mode through the matching of the insertion rod and the insertion groove, when the lower end face of the pressing platform is flush with the upper end face of the bearing platform, the main pressing groove and the main bearing groove form a bulging area, and the side pressing grooves and the side bearing grooves form a pressing area.

Further, the up end of main pressure platform is provided with the installation body, the last mounting hole that link up has been seted up on the installation body, the mounting hole is the slope and arranges and communicate with main pressure groove, the last orifice department of mounting hole extends there is the extension platform, the extension bench is seted up the extension hole that link up and is extended hole and coaxial the arranging of mounting hole, the upper end of extending the platform is provided with the support, install motor one on the support, coaxial arrangement has the sliding sleeve in the mounting hole, constitute sealed sliding guide cooperation between sliding sleeve and the mounting hole, the region that the mounting hole is located sliding sleeve one side towards main pressure platform is the negative pressure zone.

Furthermore, the upper end of the sliding sleeve is opened, the lower end of the sliding sleeve is closed, the closed end of the sliding sleeve is detachably provided with an acquisition needle head, a core pipe coaxially extends from the bottom of the cavity of the sliding sleeve, and the core pipe is communicated with the acquisition needle head;

the support is fixedly provided with a fixing column, the fixing column is in a hollow shaft shape coaxially arranged with the sliding sleeve, the fixing column is coaxially sleeved outside the core pipe, the fixing column and the sliding sleeve form sliding guide fit through a guide piece, a threaded rod is arranged between the fixing column and the sliding sleeve, the threaded rod is hollow inside and forms threaded connection with the sliding sleeve, the upper end of the threaded rod extends out of the sliding sleeve and is in power connection with a motor, and the threaded rod and the support form rotating connection.

Furthermore, a sensor is arranged at the bottom of the main bearing platform and used for sensing the moving distance of the collecting needle head.

Further, still install the peristaltic pump in the housing, realize through connecting pipe one between the feed liquor end of peristaltic pump and the core pipe and connect the switch-on, realize through connecting pipe two between the play liquid end of peristaltic pump and the blood sampling bag of placing on blood storage unit and connect the switch-on, blood storage unit is used for rocking the blood sampling bag at the umbilical cord blood collection in-process.

Further, store up the blood unit and include base and tray, the tray is used for the bearing blood sampling bag, and the bottom of tray is provided with adjustable shelf and the articulated setting of adjustable shelf on the base.

Furthermore, a second motor is installed on the base, a swing rod is arranged on the movable frame, the axial directions of the swing rod and the second motor are parallel to the axial direction of a hinge shaft formed at the hinge position between the movable frame and the base, a cam is arranged at the output end of the second motor, a swing arm is arranged between the cam and the swing rod and perpendicular to the swing rod, one end of the swing arm is hinged to the cam, and the other end of the swing arm is rotatably connected with the swing rod.

Compared with the prior art, the invention has the beneficial effects that:

1. the nuclear core point of this scheme lies in, during the acupuncture, has compromise difficult slipping and has avoided pricking the navel cord, has solved in the current umbilical cord blood collection technology who mentions in the background art, when gathering the acupuncture, the difficult slipping and the problem of avoiding pricking the navel cord and being difficult to compromise are specifically expounded as follows:

after the insertion connection between the pressing table and the bearing table is realized through the matching of the insertion rod and the insertion slot, and the lower end face of the pressing table is attached to the upper end face of the bearing table, the peristaltic pump is started to suck air in the negative pressure region through the first connecting pipe, the core pipe and the collecting needle, and the air is discharged through the second connecting pipe, so that the negative pressure state is formed in the negative pressure region, in the process, the umbilical cord in the bulging region bulges under the action of negative pressure, and finally the umbilical cord is shown in figure 15, and for convenience of description, the umbilical cord is respectively named as bulging b in the bulging region, flat a on two sides of the bulging b and bulging c at the communication part of the bulging region and the negative pressure region;

then, the threaded rod is driven to rotate by starting the motor, so that the sliding sleeve and the collecting needle head move towards the bulge c, in the process, the peristaltic pump continuously operates, before the collecting needle head is not in contact with the bulge c, the volume of the negative pressure area is reduced along with the movement of the sliding sleeve, but air in the negative pressure area is continuously sucked and exhausted, so that the negative pressure state is still kept in the negative pressure area, the bulge c still exists, when the collecting needle head is in contact with the bulge c, the point where the bulge c is in contact with the collecting needle head is named as a needle pricking point, the included angle between the tangent line of the bulge c at the needle pricking point and the collecting needle head is larger and is far larger than that the needle point inclined plane of the blood taking needle mentioned in the background technology and is smaller than ten degrees downwards, so that the slipping phenomenon can be prevented when the needle is pricked, and the needle point can be pricked into the umbilical cord due to continuous small amplitude movement after the contact of the collecting needle head with the bulge b, in the needle pricking process, the negative pressure state in the pricking area changes slightly, and the situation that the collecting needle head is not influenced to be smoothly inserted into the umbilical cord;

after the needle point of the collecting needle head is pricked into the umbilical cord, the first motor continuously operates to drive the sliding sleeve and the collecting needle head to move, when the distance between the collecting needle head and the bottom of the main bearing groove is close to the wall thickness of the umbilical cord, the sensor sends a signal to the control main board, the control main board sends a signal to the first motor, and the first motor stops operating;

comprehensively, the umbilical cord is expanded by the negative pressure state in the negative pressure area to form an expansion b and an expansion c, the expansion c is favorable for the collection needle to penetrate into the umbilical cord, the slipping problem is avoided, the expansion b is matched with the sensor, the collection needle can be prevented from penetrating the umbilical cord, and the needle point can be close to the bottom of the umbilical cord as far as possible, namely, the slip prevention and the puncture prevention of the umbilical cord are both considered during the puncturing.

2. After the puncture needle is finished, in the process of continuously operating the peristaltic pump to collect umbilical cord blood, along with the fact that the umbilical cord blood in the bulging b is extracted and collected, the pressure in the bulging b becomes small, the bulging degree is reduced to drive, meanwhile, the flat a becomes flatter under the extrusion of the atmospheric pressure and extrudes the umbilical cord blood in the flat a into the bulging b, when the umbilical cord blood in the flat a is not completely extruded and flows into the bulging b, the bulging b keeps unchanged, the flow of the umbilical cord blood is facilitated by the bulged umbilical cord, and the collection efficiency of the umbilical cord blood is further improved.

Drawings

FIG. 1 is a schematic view of the present invention with the lower support unit unconnected to the upper acquisition unit;

FIG. 2 is a schematic view of the present invention with the lower support unit connected to the upper acquisition unit;

fig. 3 is a schematic structural view of the lower support unit;

fig. 4 is an exploded view of the lower support unit;

FIG. 5 is a cross-sectional view of the main support platform, temperature control element, and sensor;

FIG. 6 is a schematic structural view of an upper collection unit;

FIG. 7 is an internal schematic view of an upper acquisition unit;

FIG. 8 is a bottom view of the platen table;

FIG. 9 is a partial schematic view of an upper acquisition unit;

FIG. 10 is a schematic view of a first motor, a sliding sleeve and a collection needle;

FIG. 11 is a cross-sectional view of the sliding sleeve, collection needle, core tube, fixation post and threaded rod;

FIG. 12 is an exploded view of the sliding sleeve, collection needle, core tube, fixation post and threaded rod;

FIG. 13 is a schematic structural view of a blood storage unit;

FIG. 14 is a partial schematic view of a blood storage unit;

FIG. 15 is a schematic view of the umbilical cord when the pressure platform is connected to the supporting platform and the negative pressure zone is in a negative pressure state.

The reference numbers in the drawings are:

100. a lower support unit; 101. a chassis; 102. a main bearing platform; 103. a first side bearing platform; 104. a second side bearing platform; 105. a magnetic strip; 106. a sensor; 107. a temperature control element; 108. a chuck; 109. a jack;

200. an upper acquisition unit; 201. a main pressing table; 202. a housing; 203. a peristaltic pump; 204. a first connecting pipe; 205. a second connecting pipe; 206. a first side pressing table; 207. a second side pressing table; 208. an upper mounting body; 209. mounting holes; 210. a plug; 211. an extension stage; 212. a support; 213. a first motor; 214. a sliding sleeve; 215. collecting a needle head; 216. a core tube; 217. fixing a column; 218. a threaded rod;

300. a blood storage unit; 301. a base; 302. a tray; 303. a movable frame; 304. a second motor; 305. swinging arms; 306. a swing link.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description of the embodiments, structures, features and effects according to the present invention will be made with reference to the accompanying drawings and preferred embodiments.

As shown in fig. 1 to 15, a stem cell extractor comprises an umbilical cord blood collecting device and a blood storage unit 300, wherein the umbilical cord blood collecting device is used for collecting umbilical cord blood and drawing the umbilical cord blood to move towards the blood storage unit 300, a blood collection bag placed on the blood storage unit 300 is stored, and the blood storage unit 300 draws the blood collection bag to continuously shake in the process of collecting the umbilical cord blood, so that an anticoagulant in the blood collection bag is fully and uniformly mixed with the umbilical cord blood.

The umbilical cord blood collection device comprises a lower support unit 100 and an upper collection unit 200, the lower support unit 100 and the upper collection unit 200 are detachably connected, an installation area for installing an umbilical cord is formed between the lower support unit 100 and the upper collection unit 200, the installation area is divided into an expansion area and pressing areas located at two ends of the expansion area along the extending direction, the pressing areas and the umbilical cord form interference fit, the volume of the expansion area is larger than that of the pressing areas, and a reserved space for negative pressure expansion of the umbilical cord in the expansion area is reserved.

The negative pressure zone communicated with the bulging zone is arranged in the upper collecting unit 200, the umbilical cord in the bulging zone can be bulged through negative pressure in the negative pressure zone, the collecting needle 215 arranged in the negative pressure zone is convenient to prick the umbilical cord, the umbilical cord is not easy to slip during pricking, and the umbilical cord can be prevented from being pricked, namely, the umbilical cord is not easy to slip and prevented from being pricked during pricking.

When in use, firstly, the umbilical cord is cut off after the position of 10-15 cm of the end of a newborn is clamped by a clamping head 108;

then, the umbilical cord is simply wiped by the sterile gauze and then placed in the placing area, so that the step of wiping the sterile gauze is simplified, the time occupied by the step can be reduced, and enough time is reserved for the subsequent collection of umbilical cord blood;

then the upper acquisition unit 200 is inserted into the lower support unit 100, because the umbilical cord has certain elastic deformation capability like the skin and flesh of a human body, and because the size of the cross section of the umbilical cord of a newborn is not large, after the upper acquisition unit 200 is inserted into the lower support unit 100, the pressing and holding area of the placement area is folded and attached to the umbilical cord in the pressing and holding area;

then, the upper collection unit 200 makes the negative pressure region in a negative pressure state, and under the action of negative pressure, the umbilical cord in the bulging region is as shown in fig. 15, bulging b occurs and a bulge c is formed at the communication position of the negative pressure region and the bulging region, so that subsequent collection acupuncture is facilitated, the umbilical cord is not easy to slip and puncture during acupuncture, the slip and puncture prevention of the umbilical cord are both considered, in addition, the bulging b is beneficial to the continuous flow of the umbilical cord blood source at the flat a positions on the two sides to the bulging b, and the blood collection efficiency is improved.

As shown in fig. 3 to 5, the lower support unit 100 includes a base frame 101 and a clamp 108, and the clamp 108 is used for clamping the umbilical cord.

The bearing platform that is the level and arranges is installed to chassis 101's upper end, the bearing platform comprises main bearing platform 102 and side bearing platform, wherein, side bearing platform is provided with two sets ofly and is located the both ends of main bearing platform 102 respectively, the up end of main bearing platform 102 is provided with the main bearing groove that runs through its length, the up end of side bearing platform is provided with the side bearing groove that runs through its length, communicate each other between main bearing groove and the side bearing groove and communicate department fillet, the up end of side bearing platform still is provided with the slot that runs through its height, two sets of side bearing platforms do respectively: a first side bearing platform 103 and a second side bearing platform 104.

The upper end face of the main support platform 102 is provided with a magnetic strip groove, a magnetic strip 105 is installed in the magnetic strip groove, and the upper end face of the magnetic strip 105 is flush with the upper end face of the main support platform 102.

As shown in fig. 6-8, the upper collecting unit 200 includes a pressing table, the pressing table is composed of a main pressing table 201 and side pressing tables, wherein the side pressing tables are disposed at two sides and located at two ends of the main pressing table 201 respectively, the upper end face of the main pressing table 201 is provided with a cover 202, the lower end face of the main pressing table is provided with a main pressing groove running through the length of the main pressing table, the lower end face of the side pressing table is provided with a side pressing groove running through the length of the side pressing table, the side pressing groove and the main pressing groove are communicated with each other and the communicated part is chamfered, the lower end face of the side pressing table is further provided with an inserting rod, the inserting rod is correspondingly matched with an inserting groove disposed at the upper end face of the side supporting table, and the two sets of side pressing tables are respectively: a first side press station 206 and a second side press station 207.

The lower end face of the main pressure table 201 is provided with an electromagnetic groove, an electromagnet is arranged in the electromagnetic groove, the lower end face of the electromagnet is flush with the lower end face of the main pressure table 201, the electromagnet is correspondingly matched with the magnetic strip 105 arranged on the main bearing table 102, and magnetic adsorption force is generated between the electromagnet and the magnetic strip 105 when the electromagnet is electrified.

The inserting connection between the pressing table and the bearing table can be achieved through the matching of the inserting rod and the inserting groove, the lower end face of the pressing table is attached to the upper end face of the bearing table, then the pressing table and the bearing table are limited through magnetic adsorption force generated between the electromagnet and the magnetic strip 105 in a powered-on mode, the detachable connection between the pressing table and the bearing table is achieved, at the moment, the main pressing groove and the main bearing groove form a bulging area, and the side pressing grooves and the side bearing grooves form a pressing area.

As shown in fig. 8 and 9, an upper mounting body 208 is disposed on an upper end surface of the main pressure table 201, a through mounting hole 209 is formed in the upper mounting body 208, the mounting hole 209 is obliquely disposed and is communicated with the main pressure groove, an extending table 211 extends from an upper hole of the mounting hole 209, and a through extending hole is formed in the extending table 211 and is coaxially disposed with the mounting hole 209.

As shown in fig. 9 to 12, a bracket 212 is provided at an upper end of the extension table 211, and a first motor 213 is mounted on the bracket 212.

A sliding sleeve 214 is coaxially arranged in the mounting hole 209, a sealed sliding guide fit is formed between the sliding sleeve 214 and the mounting hole 209, the upper end of the sliding sleeve 214 is open, the lower end of the sliding sleeve 214 is closed, and the region of the mounting hole 209, which is located on one side of the sliding sleeve 214 facing the main pressure table 201, is a negative pressure region.

The collection needle 215 is detachably mounted at the closed end of the sliding sleeve 214, the core tube 216 coaxially extends from the cavity bottom of the sliding sleeve 214, the core tube 216 is communicated with the collection needle 215, and specifically, the closed end of the sliding sleeve 214 is provided with a connecting hole for communicating the core tube 216 with the collection needle 215.

The fixing column 217 is fixedly arranged on the support 212, the fixing column 217 is in a hollow shaft shape coaxially arranged with the sliding sleeve 214, the fixing column 217 is coaxially sleeved outside the core tube 216, the fixing column 217 and the core tube 216 form sliding guide fit through a guide piece, specifically, the guide piece comprises a guide protrusion arranged on the outer wall of the core tube 216 and a guide groove arranged on the inner wall of the fixing column 217, and sliding guide fit along the axial direction of the core tube 216 is formed between the guide protrusion and the guide groove.

A threaded rod 218 is arranged between the fixed column 217 and the sliding sleeve 214, the threaded rod 218 is hollow and forms threaded connection with the sliding sleeve 214, the upper end of the threaded rod 218 extends out of the sliding sleeve 214 and is in power connection with a motor I213, specifically, the power connection is realized through belt transmission, and the threaded rod 218 is also in rotational connection with the bracket 212.

When the first motor 213 is started to drive the threaded rod 218 to rotate, the sliding sleeve 214 moves along the axial direction of the negative pressure area, and the sliding sleeve 214 moves with the collection needle 215, so that the collection needle 215 moves towards or away from the ballooning area.

As shown in fig. 5, a sensor 106 is disposed at the bottom of the main supporting platform 102, the sensor 106 is configured to sense a moving distance of the collecting needle 215, when a distance between the collecting needle 215 and the bottom of the main supporting groove is close to a wall thickness of the umbilical cord, the sensor 106 sends a signal to the control main board, the control main board sends a signal to the first motor 213, and the first motor 213 stops running, at this time, the collecting needle 215 does not penetrate the umbilical cord and is close to the bottom of the umbilical cord as much as possible, so that umbilical cord blood located in the tympanites and occurring in the tympanites b can be collected better and more thoroughly, the collecting needle 215 is generally made of a metal material, the sensor 106 may be a magnetic sensor or a metal sensor, and the like, which is realized by the prior art, and is not described in detail.

As shown in fig. 7 and 12, a peristaltic pump 203 is further installed in the housing 202, a first connection pipe 204 is used for connecting the liquid inlet end of the peristaltic pump 203 with the core tube 216, and a second connection pipe 205 is used for connecting the liquid outlet end of the peristaltic pump 203 with a blood collection bag placed on the blood storage unit 300.

The nuclear core point of this scheme lies in, during the acupuncture, has compromise difficult slipping and has avoided pricking the navel cord, has solved in the current umbilical cord blood collection technology who mentions in the background art, when gathering the acupuncture, the difficult slipping and the problem of avoiding pricking the navel cord and being difficult to compromise are specifically expounded as follows:

firstly, the umbilical cord is cut off after the neonate is clamped by a clamping head 108 at the position of 10-15 cm from the end of the neonate;

then, the umbilical cord is simply wiped by using sterile gauze and then placed in the main bearing groove and the side bearing grooves, so that the step of wiping the sterile gauze is simplified, the time occupied by the step can be reduced, and enough time is reserved for the subsequent collection of umbilical cord blood;

then, the insertion connection between the pressing table and the bearing table is realized through the matching of the insertion rod and the insertion slot, the lower end face of the pressing table is attached to the upper end face of the bearing table, the pressing table and the bearing table are limited through the magnetic adsorption force generated between the electromagnet and the magnetic strip 105 when the electromagnet is electrified, the detachable connection between the pressing table and the bearing table is realized, at the moment, the main pressing groove and the main bearing groove form a bulging area, and the side pressing groove and the side bearing groove form a pressing area;

then, the peristaltic pump 203 starts to suck air in the negative pressure region through the first connecting pipe 204, the core pipe 216 and the collecting needle 215, and the air is discharged through the second connecting pipe 205, so that the negative pressure state is formed in the negative pressure region, in the process, the umbilical cord in the expansion region expands under the action of negative pressure, and finally the umbilical cord is as shown in fig. 15;

then, the first motor 213 is started to drive the threaded rod 218 to rotate, so that the sliding sleeve 214 and the collecting needle 215 move towards the bulge c, in the process, the peristaltic pump 203 continuously operates, before the collecting needle 215 is not in contact with the bulge c, the volume of a negative pressure area is reduced along with the movement of the sliding sleeve 214, but air in the negative pressure area is continuously sucked and exhausted, so that the negative pressure state is still kept in the negative pressure area, the bulge c still exists, when the collecting needle 215 is in contact with the bulge c, the point where the bulge c is in contact with the collecting needle 215 is named as a needle pricking point, the included angle between the tangent line of the bulge c at the needle pricking point and the collecting needle 215 is larger, and is far smaller than ten degrees downwards than the needle point inclined plane of the blood taking needle mentioned in the background technology, so that the needle slipping phenomenon can be prevented, and the needle point can be pricked into an umbilical cord by continuously moving in a small amplitude after the collecting needle 215 is in contact with the bulge b, so that the negative pressure state in the negative pressure area is changed slightly in the needle pricking process, and the collection needle 215 is not influenced to be smoothly pricked into the umbilical cord;

after the needle point of the collecting needle head 215 is pricked into the umbilical cord, the first motor 213 continues to operate to drive the sliding sleeve 214 and the collecting needle head 215 to move, when the distance between the collecting needle head 215 and the bottom of the main bearing groove is close to the wall thickness of the umbilical cord, the sensor 106 sends a signal to the control main board, the control main board sends a signal to the first motor 213, the first motor 213 stops operating, at the moment, the collecting needle head 215 does not prick the umbilical cord and is as close to the bottom of the umbilical cord as possible, in the process, because the needle point of the collecting needle head 215 is positioned in the umbilical cord, air in a negative pressure area is not sucked and discharged, although the negative pressure is kept in the negative pressure area, the pressure is increased, and therefore, the bulge c slowly disappears, but the bulge b of the umbilical cord still keeps in a bulging state, in addition, in the process, the peristaltic pump 203 operates to pull umbilical cord blood in the umbilical cord to sequentially pass through the collection needle 215, the core tube 216, the first connecting tube 204 and the second connecting tube 205, when observing that umbilical cord blood exists in the first connecting tube 204, medical staff immediately connect the second connecting tube 205 with the blood collection bag, and because the height of the blood collection bag is lower than that of the blood collection end during umbilical cord blood collection, in the scheme, the height of the blood collection bag is lower than that of the umbilical cord blood collection device, as shown in fig. 1 and 2, enough length is reserved between the first connecting tube 204 and the second connecting tube 205, and the time for the umbilical cord blood to pass through the first connecting tube 204 and the second connecting tube 205 is enough for the medical staff to react and complete connection between the second connecting tube 205 and the blood collection bag;

in the process, the umbilical cord forms bulge b and bulge c under the negative pressure state in the negative pressure area, the bulge c is favorable for the collection needle 215 to be inserted into the umbilical cord, so that the problem of slipping is avoided, the bulge b is matched with the sensor 106, the collection needle 215 can be prevented from penetrating the umbilical cord, and the needle point can be prevented from approaching the bottom of the umbilical cord as much as possible, namely, the slip prevention and the puncture prevention of the umbilical cord are both considered during the puncturing;

in addition, after the puncturing needle is finished, in the process of continuously operating the peristaltic pump 203 to collect umbilical cord blood, as the umbilical cord blood in the ballooning b is extracted and collected, the pressure in the ballooning b is reduced, the ballooning degree is reduced to drive, meanwhile, the flat a becomes flatter under the extrusion of the atmospheric pressure and extrudes the umbilical cord blood in the flat a into the ballooning b, and when the umbilical cord blood in the flat a is not completely extruded and flows into the ballooning b, the ballooning b keeps the ballooning constant, the flow of the umbilical cord blood is facilitated by the ballooning umbilical cord, and the collection efficiency of the umbilical cord blood is further improved.

In a preferred embodiment, as shown in fig. 3 and 8, the bottom of the slot is provided with a jack 109, the bottom of the inserted link is provided with a plug 210, and the plug 210 is correspondingly matched with the jack 109, which means that after the insertion between the pressure table and the support table is completed, the plug 210 is inserted into the jack 109, so as to realize the circuit connection between the lower support unit 100 and the upper acquisition unit 200, and reduce the circuit wires, otherwise, the lower support unit 100 and the upper acquisition unit 200 have independent circuit wires, so that in the using process, too many wires are provided, and medical staff are easily tripped or the wires are easily wound and knotted, and the plug 210 and the jack 109 can be replaced by technical means such as a contact piece.

In a preferred embodiment, a temperature control element 107 is further disposed at the bottom of the main supporting platform 102, and is used for making the umbilical cord blood in a suitable temperature range, for example, 36-37 degrees centigrade, so as to facilitate the flow of the umbilical cord blood and further facilitate the collection of the umbilical cord blood during the umbilical cord blood collection process, and the temperature control element 107 is implemented by a conventional technical means, and is not described herein.

As shown in fig. 13 and 14, when collecting umbilical cord blood, the height of the blood storage unit 300 should be lower than the height of the collection needle 215, and the blood storage unit 300 is used for shaking the blood collection bag during the process of collecting umbilical cord blood, so that umbilical cord blood and anticoagulant are fully mixed, the action of shaking the blood collection bag by medical personnel at a simulation location is simulated, and the labor intensity of the medical personnel is reduced.

Specifically, the blood storage unit 300 includes a base 301 and a tray 302, the tray 302 is used for supporting the blood collection bag, the bottom of the tray 302 is provided with a movable frame 303, the movable frame 303 is hinged to the base 301, a hinge axis formed at the hinge is horizontal, and here, it should be noted that the connection between the blood collection bag and the second connection tube 205 is detachable as in the prior art.

The second motor 304 is installed on the base 301, the swing rod 306 is arranged on the movable frame 303, the axial directions of the swing rod 306 and the second motor 304 are both parallel to the axial direction of a hinge shaft formed at the hinge joint between the movable frame 303 and the base 301, a cam is arranged at the output end of the second motor 304, a swing arm 305 is arranged between the cam and the swing rod 306, the swing arm 305 is perpendicular to the swing rod 306, one end of the swing arm 305 is hinged to the cam, the other end of the swing arm 305 is rotatably connected with the swing rod 306, concretely, the hinge shaft formed at the hinge joint between the swing arm 305 and the cam is parallel to the swing rod 306, the hinge joint is eccentrically arranged on the cam, and the other end of the swing arm 305 is provided with a sleeve hole and movably sleeved on the outside of the swing rod 306 through the sleeve hole.

The second motor 304 drives the cam to rotate, the cam rotates to pull the movable frame 303 to deflect left and right around a hinge shaft between the movable frame 303 and the base 301 through the matching of the swing arm 305 and the swing rod 306, the movable frame 303 deflects to drive the tray 302 and the blood sampling bag placed on the tray 302 together, namely the shaking action of the blood sampling bag at the simulation position is realized, and the labor intensity of medical staff is reduced.

Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. A stem cell extractor, includes umbilical cord blood collection system and blood storage unit (300), its characterized in that: the umbilical cord blood collection device comprises a lower support unit (100) and an upper collection unit (200), wherein the lower support unit (100) and the upper collection unit (200) are detachably connected with each other, a placement area for placing an umbilical cord is formed between the lower support unit (100) and the upper collection unit (200), the placement area is divided into an expansion area and two pressing areas respectively located at two ends of the expansion area along the extension direction, the volume of the expansion area is larger than that of the pressing areas, the connecting part between the expansion area and the pressing areas is rounded, a negative pressure area communicated with the expansion area is arranged in the upper collection unit (200), the umbilical cord located in the expansion area is expanded through negative pressure in the negative pressure area, and the umbilical cord forms an expansion bag at the communication part between the negative pressure area and the expansion area;

the lower supporting unit (100) comprises an underframe (101) and a chuck (108), the chuck (108) is used for clamping an umbilical cord, the upper end of the underframe (101) is provided with two groups of bearing tables which are horizontally arranged, each bearing table consists of a main bearing table (102) and a side bearing table, the side bearing tables are provided with two groups of bearing tables which are respectively positioned at two ends of the main bearing table (102), the upper end surface of the main bearing table (102) is provided with a main bearing bracket which runs through the length of the main bearing table, the upper end surface of the side bearing table is provided with a side bearing bracket which runs through the length of the side bearing table, the main bearing bracket and the side bearing groove are communicated with each other and are provided with a fillet, and the upper end surface of the side bearing table is also provided with a slot which runs through the height of the side bearing table;

when in use, firstly, the umbilical cord is cut off after the position of 10-15 cm of the neonatal end is clamped by a clamping head (108);

then the upper acquisition unit (200) is inserted into the lower support unit (100), as the umbilical cord has certain elastic deformation capacity like human skin and flesh and the size of the cross section of the umbilical cord of a newborn is not large, after the upper acquisition unit (200) is inserted into the lower support unit (100), the pressing area of the placement area is folded and attached to the umbilical cord in the pressing area;

then, the upper collection unit (200) enables the negative pressure area to be in a negative pressure state, bulging b occurs under the action of negative pressure, and a bulge c is formed at the communication position of the negative pressure area and the bulging area, so that subsequent collection acupuncture is facilitated, an umbilical cord is not easy to slip and puncture during acupuncture, the anti-slip and anti-puncture umbilical cord are both considered, in addition, the bulging b facilitates the umbilical cord blood source at the flat a positions at two sides to continuously flow into the bulging b, and the blood collection efficiency is improved;

the umbilical cord is divided into a bulge b positioned in a bulge area, flat bulges a positioned on two sides of the bulge b and bulges c positioned at the communication part of the bulge area and the negative pressure area.

2. A stem cell extractor according to claim 1, wherein: the upper acquisition unit (200) comprises a pressing table, the pressing table is composed of a main pressing table (201) and side pressing tables, the side pressing tables are provided with two groups and located at two ends of the main pressing table (201) respectively, a cover shell (202) is arranged on the upper end face of the main pressing table (201), a main pressing groove penetrating through the length of the main pressing table is arranged on the lower end face of the main pressing table, a side pressing groove penetrating through the length of the side pressing table is arranged on the lower end face of the side pressing table, the side pressing groove and the main pressing groove are communicated with each other and are provided with a fillet at the communicating part, an inserting rod is further arranged on the lower end face of the side pressing table, and the inserting rod is correspondingly matched with an inserting groove formed in the upper end face of the side supporting table.

3. A stem cell extractor according to claim 2, wherein: the upper end face of the main bearing platform (102) is provided with a magnetic strip groove, a magnetic strip (105) is installed in the magnetic strip groove, the upper end face of the magnetic strip (105) is flush with the upper end face of the main bearing platform (102), the lower end face of the main pressing platform (201) is provided with an electromagnetic groove, an electromagnet is arranged in the electromagnetic groove, the lower end face of the electromagnet is flush with the lower end face of the main pressing platform (201), the electromagnet is correspondingly matched with the magnetic strip (105) arranged on the main bearing platform (102), magnetic attraction force is generated between the electromagnet and the magnetic strip (105) when the electromagnet is powered on, the main pressing groove and the main bearing groove are matched to realize insertion connection between the pressing platform and the bearing platform, and when the lower end face of the pressing platform is in contact with the upper end face of the bearing platform, the main pressing groove and the main bearing groove form a bulging area, and the side pressing area are formed by the side pressing groove and the side bearing groove.

4. A stem cell extractor as claimed in claim 3, wherein: the upper end face of main pressure platform (201) is provided with installation body (208), the last mounting hole (209) of having seted up the link up on installation body (208), mounting hole (209) are the slope and arrange and communicate with the main pressure groove, the last orifice department of mounting hole (209) extends and has extension platform (211), it just extends hole and mounting hole (209) coaxial arrangement to set up the extension hole that link up on extension platform (211), the upper end of extending platform (211) is provided with support (212), install motor one (213) on support (212), coaxial mounting has sliding sleeve (214) in mounting hole (209), constitute sealed sliding guide cooperation between sliding sleeve (214) and mounting hole (209), the region that mounting hole (209) are located sliding sleeve (214) towards main pressure platform (201) one side is the negative pressure zone.

5. A stem cell extractor according to claim 4, wherein: the upper end of the sliding sleeve (214) is opened, the lower end of the sliding sleeve (214) is closed, the closed end of the sliding sleeve (214) is detachably provided with a collecting needle (215), the cavity bottom of the sliding sleeve (214) coaxially extends to form a core pipe (216), and the core pipe (216) is communicated with the collecting needle (215);

the fixing column (217) is fixedly arranged on the support (212), the fixing column (217) is in a hollow shaft shape coaxially arranged with the sliding sleeve (214), the fixing column (217) is coaxially sleeved outside the core pipe (216), the fixing column (217) and the sliding sleeve (214) form sliding guide fit through a guide piece, a threaded rod (218) is arranged between the fixing column (217) and the sliding sleeve (214), the threaded rod (218) is hollow inside and is in threaded connection with the sliding sleeve (214), the upper end of the threaded rod (218) extends out of the sliding sleeve (214) and is in power connection with a first motor (213), and the threaded rod (218) and the support (212) form rotating connection.

6. A stem cell extractor according to claim 5, wherein: the bottom of the main supporting platform (102) is provided with a sensor (106), and the sensor (106) is used for sensing the moving distance of the acquisition needle head (215).

7. The stem cell extractor of claim 6, wherein: still install peristaltic pump (203) in housing (202), realize connecting through connecting pipe (204) between the feed liquor end of peristaltic pump (203) and core pipe (216) and connect, realize connecting through connecting pipe two (205) between the play liquid end of peristaltic pump (203) and the blood collection bag of placing on blood storage unit (300) and connect, blood storage unit (300) are used for rocking the blood collection bag at the umbilical cord blood collection in-process.

8. A stem cell extractor as claimed in claim 7, wherein: blood storage unit (300) include base (301) and tray (302), and tray (302) are used for the bearing to take a blood bag, and the bottom of tray (302) is provided with adjustable shelf (303) and adjustable shelf (303) articulated the setting on base (301).

9. A stem cell extractor according to claim 8, wherein: a second motor (304) is installed on the base (301), a swing rod (306) is arranged on the movable frame (303), the axial directions of the swing rod (306) and the second motor (304) are both parallel to the axial direction of a hinge shaft formed at the hinged position between the movable frame (303) and the base (301), a cam is arranged at the output end of the second motor (304), a swing arm (305) is arranged between the cam and the swing rod (306), the swing arm (305) is perpendicular to the swing rod (306), one end of the swing arm (305) is hinged to the cam, and the other end of the swing arm is rotatably connected with the swing rod (306).