CN115350120A - Hand-mouth wet tissue composition and wet tissue for infants - Google Patents
Hand-mouth wet tissue composition and wet tissue for infants Download PDFInfo
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- CN115350120A CN115350120A CN202210965581.7A CN202210965581A CN115350120A CN 115350120 A CN115350120 A CN 115350120A CN 202210965581 A CN202210965581 A CN 202210965581A CN 115350120 A CN115350120 A CN 115350120A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
The invention provides an infant hand and mouth wet tissue composition, which is characterized by comprising gluconolactone, sodium benzoate, potassium sorbate and orange peel oil. The invention also provides a wet tissue for hands and mouths of infants, which is characterized by comprising the wet tissue composition and non-woven fabrics containing the wet tissue composition.
Description
Technical Field
The invention relates to the technical field of sanitary product wet tissues, in particular to a hand and mouth wet tissue composition for infants and a wet tissue.
Background
The wet tissue for hands and mouths of infants is a special wet tissue for cleaning the hands, faces, oral cavities and other parts of infants. The skin around the mouth of the infant is fragile and therefore susceptible to damage from residue irritation. Recent japanese literature also found: the damaged skin comes into contact with allergen substances and is absorbed by the body, resulting in allergic reactions of the body. Thus, care needs to be taken after the nozzle Zhou Jifu is cleaned. At present, the hand wet tissue on the market can be taken in by adding xylitol, namely, the hand wet tissue is alleged to be capable of entering the mouth, and some additives are too much, so that the anticorrosion system is not different from the common wet tissue, and the difference between the hand wet tissue and the common wet tissue is not emphasized.
In order to ensure that the wet tissue has a longer shelf life, preservatives such as polyhexamethylene biguanide, chlorhexidine gluconate, nipagin ester, benzyl alcohol and the like are mostly added to the wet tissue for babies in the current market. Since preservatives generally have a characteristic odor, after application of these preservatives to infant hand and mouth wipes, infants and young children may resist using these existing wipes. Therefore, in order to mask the special odor of the existing infant hand and mouth wet wipes, sweetener components such as stevioside, xylitol, sorbitol, erythritol and the like are mostly added to the infant hand and mouth wet wipes on the market at present (see CN106176291A and CN 108078846A). The preservatives used in the above-mentioned patent applications are mostly of cosmetic grade and are not different from the preservative systems used for ordinary wet wipes. The hand and mouth wet tissue is mainly used for cleaning hands and mouths of infants Zhou Jifu, and the safety of the formula needs special attention, so that the skin around the mouths of the infants needs to be considered to be more sensitive when raw materials are selected, the possibility of sucking and chewing exists, and the formula needs to be selected to be safer. The full food grade preservatives potassium sorbate and sodium benzoate that can be used in food formulations are relatively safe (see Wang Guojun et al, potassium sorbate performance and its use; hu Li et al, for the safety of benzoic acid and sodium benzoate). However, potassium sorbate is easy to turn yellow, and sodium benzoate has a relatively obvious smell (see Liu Xin, etc., high performance liquid chromatography is used for simultaneously detecting 4 preservatives, namely sodium benzoate, potassium sorbate, p-anisic acid and sodium dehydroacetate, in cosmetics).
Previously, the addition of cyclodextrins was commonly employed in the art to mask the odor. Cyclodextrin is a cyclic oligomer, the special cyclic structure of which has a certain embedding effect, and is used for covering bad smell in the food and medicine industries. However, the inventors have found that the effect of adding cyclodextrin to a hand-held wet wipe composition for infants to mask odors is not satisfactory.
Disclosure of Invention
The inventor unexpectedly finds that when food-grade preservatives potassium sorbate and sodium benzoate are used as the preservatives of the infant hand-mouth wet tissue, the formula can be stabilized and the preservative synergistic effect can be achieved by adding gluconolactone as a chelating agent; and the problem of smell of the product can be solved by adding the food-grade sweet orange peel oil.
Therefore, the invention aims to provide a baby hand-mouth wet tissue composition for cleaning the hand-mouth part of a baby, which is different from the conventional wet tissue liquid medicine, selects a full-food grade raw material formula and does not add controversial components such as propylene glycol and paraben.
In order to achieve the above object, a first aspect of the present invention provides an infant hand and mouth wet wipe composition, characterized in that the wet wipe composition comprises gluconolactone, sodium benzoate, potassium sorbate and orange peel oil.
As described above, the sodium benzoate and potassium sorbate contained in the infant hand-mouth wet tissue composition provided by the invention are used as preservatives, so that the wet tissue has a longer shelf life; gluconolactone is used as a chelating agent, can stabilize the formula and has the functions of corrosion prevention and synergism; the sweet orange peel oil can solve the odor problem of the hand and mouth wet tissue composition.
According to a preferred embodiment, the wet wipe composition comprises, in weight percent, gluconolactone 0.10-2.00%, sodium benzoate 0.10-0.50%, potassium sorbate 0.01-0.2%, and orange peel oil 0.001-0.1%.
According to another preferred embodiment, the wet wipe composition comprises, in weight percent, gluconolactone 0.50-1.00%, sodium benzoate 0.30-0.50%, potassium sorbate 0.05-0.10%, and orange peel oil 0.001-0.01%.
According to a preferred embodiment, the wet wipe composition may further comprise one or more of a polyol, a polysaccharide, glycogen, a pH adjuster, and a chelating agent.
According to a preferred embodiment, the polyol may be selected from glycerol or propylene glycol and the like. Polyols are used as humectants and solvents in wet wipe compositions of the invention.
According to a preferred embodiment, the polysaccharide may be selected from glycogen, tremella polysaccharide, sodium hyaluronate, algal polysaccharide or rhamnose, etc. In the wet tissue composition, the polysaccharide has good water-locking and moisture-keeping effects, and forms a film on the surface of the skin, so that the water evaporation is reduced, and the skin barrier is improved.
According to a preferred embodiment, the glycogen may be corn-derived nano-glycogen. In the wet wipe composition of the present invention, glycogen has the effects of moisturizing and repairing skin barrier.
According to another preferred embodiment, the pH adjusting agent is citric acid, sodium citrate, tartaric acid, malic acid, lactic acid, potassium citrate, disodium hydrogen phosphate or sodium hydrogen carbonate. In the wet wipe composition of the present invention, the pH adjusting agent is used to adjust the pH of the composition.
According to a preferred embodiment, the wet tissue composition comprises, by weight, 1.00 to 10.00% of glycerin, 0.10 to 2.00% of gluconolactone, 0.10 to 0.50% of sodium benzoate, 0.01 to 0.2% of potassium sorbate, 0.001 to 0.1% of tremella polysaccharide, 0.001 to 0.1% of glycogen, 0.001 to 0.1% of sweet orange peel oil, 0.01 to 0.20% of citric acid, 0.01 to 0.50% of sodium citrate, and the balance of water.
According to a particularly preferred embodiment, the wet tissue composition comprises 1.00-3.00% of glycerol, 0.50-1.00% of gluconolactone, 0.30-0.50% of sodium benzoate, 0.05-0.10% of potassium sorbate, 0.001-0.01% of tremella polysaccharide, 0.001-0.01% of glycogen, 0.001-0.01% of sweet orange peel oil, 0.02-0.1% of citric acid, 0.20-0.40% of sodium citrate, and the balance of water by weight percentage.
In a second aspect of the present invention, there is provided a wet wipe for hands and mouths of infants, the wet wipe comprising the wet wipe composition described above and a nonwoven fabric containing the wet wipe composition.
According to a preferred embodiment, the mass ratio of the nonwoven fabric to the wet wipe composition is 1.
The preparation method of the wet tissue composition for hands and mouths of infants comprises the following steps: adding the selected tremella polysaccharide and glycogen into a water phase after uniformly dispersing in partial glycerol, heating to dissolve, dissolving gluconolactone at a high temperature of 70 ℃ to accelerate the decomposition of the gluconolactone and stabilize the pH value of the liquid medicine; dissolving sodium benzoate and potassium sorbate at 40 deg.C, dissolving sweet orange peel oil with the rest of glycerol, adding into water phase, and adjusting pH.
According to another embodiment, gluconolactone may also be soluble at ambient temperatures.
According to a particularly preferred embodiment, the wet wipe composition comprises, in weight percent, sodium benzoate 0.4%, potassium sorbate 0.08%, gluconolactone 0.5%, glycerin 1%, orange peel oil 0.002%, and balance water.
The preparation method of the wet tissue composition for hands and mouths of infants comprises the following steps: dissolving gluconolactone at 70 deg.C, dissolving sodium benzoate and potassium sorbate at 40 deg.C, adding sweet orange peel oil into glycerol, stirring, adding into water phase, stirring, and clarifying.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the blending of the wet tissue liquid is finished, spraying the mixed liquid on the non-woven fabric in proportion, and then folding, cutting and packaging to finish the preparation of a wet tissue product, wherein the mass ratio of the non-woven fabric to the wet tissue composition is 1.
The inventor has succeeded in unexpectedly finding that when food-grade preservatives potassium sorbate and sodium benzoate are used as preservatives for baby hand-mouth wet wipes, by adding gluconolactone as a chelating agent, the formula can be stabilized and has a preservative synergistic effect; and the problem of odor of the product can be solved by adding food-grade sweet orange peel oil. Meanwhile, the wet wipe for infants with hands of the present invention passes multiple skin irritation tests, vaginal mucosa irritation tests, oral toxicity tests, eye irritation tests, and skin patch tests. Therefore, the invention can provide the baby hand wet tissue composition which is safe and popular with babies and the baby hand wet tissue thereof.
The invention has the following technical effects:
the infant hand-mouth wet tissue composition and the infant hand-mouth wet tissue thereof use full-food grade raw materials, comprise an organic acid preservative system, and are added with gluconolactone as a chelating agent, so that the composition has the functions of preservative and synergism; and sweet orange peel oil is added, so that the odor of the organic acid can be covered, and a pleasant sweet orange fragrance is given to the product.
Detailed Description
Example 1:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.4% of sodium benzoate, 0.08% of potassium sorbate, 0.5% of gluconolactone, 1% of glycerol, 0.002% of sweet orange peel oil and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: dissolving gluconolactone at 70 deg.C, dissolving sodium benzoate and potassium sorbate at below 40 deg.C by conventional method, adding sweet orange peel oil into glycerol, stirring, adding into water phase, stirring to dissolve completely, and making the solution clear and transparent, wherein the pH value is 4.0, and the pH value is Mettler-toledo FE20.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, spraying the hand wet tissue composition on non-woven fabrics in proportion, and then folding, cutting and packaging to complete the preparation of a hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 2:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.4% of sodium benzoate, 0.08% of potassium sorbate, 1.0% of gluconolactone, 1% of glycerol, 0.002% of tremella polysaccharide, 0.001% of sweet orange peel oil, 0.2% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide is evenly dispersed in glycerol, then added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate and potassium sorbate are dissolved at the temperature of below 40 ℃ according to a conventional process, and sodium citrate is added to adjust the pH value to 4.3.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand-mouth wet tissue composition is prepared, spraying the hand-mouth wet tissue composition on non-woven fabrics in proportion, folding by a folding machine, cutting by a circular disc cutter to obtain a semi-finished product, and packaging by a packaging machine to obtain the hand-mouth wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 3:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 3.00% of glycerin, 1.00% of gluconolactone, 0.40% of sodium benzoate, 0.05% of potassium sorbate, 0.005% of tremella polysaccharide, 0.005% of glycogen, 0.001% of sweet orange peel oil, 0.05% of citric acid, 0.34% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide and glycogen are uniformly dispersed in partial glycerin, then the tremella polysaccharide and glycogen are added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate and potassium sorbate are dissolved at the temperature of below 40 ℃ according to a conventional process, the sweet orange peel oil is dissolved by the rest glycerin, the dissolved sweet orange peel oil is added into water, and citric acid and sodium citrate are added to adjust the pH value to 4.1.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, the hand wet tissue composition is sprayed on non-woven fabrics in proportion, and then the non-woven fabrics are folded by a folding machine and cut by a circular disc cutter to obtain a semi-finished product, and the semi-finished product is packaged by a packaging machine to obtain the hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 4:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.4% of sodium benzoate, 0.08% of potassium sorbate, 0.55% of gluconolactone, 2.0% of glycerol, 0.005% of tremella polysaccharide, 0.001% of sweet orange peel oil, 0.23% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: dispersing Tremella polysaccharide in partial glycerol, adding into water phase, heating to dissolve, dissolving gluconolactone at 70 deg.C, dissolving sodium benzoate and potassium sorbate at 40 deg.C, dissolving sweet orange peel oil with the rest glycerol, adding into water, adding sodium citrate, and adjusting pH to 4.2.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand-mouth wet tissue composition is prepared, spraying the hand-mouth wet tissue composition on non-woven fabrics in proportion, folding by a folding machine, cutting by a circular disc cutter to obtain a semi-finished product, and packaging by a packaging machine to obtain the hand-mouth wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 5:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 2.00% of glycerin, 0.40% of sodium benzoate, 0.1% of potassium sorbate, 0.005% of tremella polysaccharide, 0.005% of glycogen, 0.001% of sweet orange peel oil, 0.3% of citric acid, 0.01% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: dispersing Tremella polysaccharide and glycogen in partial glycerol, adding into water phase, heating to dissolve, dissolving sodium benzoate and potassium sorbate at 40 deg.C, dissolving sweet orange peel oil with the rest glycerol, adding into water, adding citric acid and sodium citrate, and adjusting pH to 4.2.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, the hand wet tissue composition is sprayed on non-woven fabrics in proportion, and then the non-woven fabrics are folded by a folding machine and cut by a circular disc cutter to obtain a semi-finished product, and the semi-finished product is packaged by a packaging machine to obtain the hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 6:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.4% of sodium benzoate, 0.08% of potassium sorbate, 0.8% of gluconolactone, 1.0% of glycerol, 0.002% of tremella polysaccharide, 0.003% of sweet orange peel oil, 0.23% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: dispersing Tremella polysaccharide in partial glycerol, adding into water phase, heating to dissolve, dissolving gluconolactone at 70 deg.C, dissolving sodium benzoate and potassium sorbate at 40 deg.C, dissolving sweet orange peel oil with residual glycerol, adding into water, adding sodium citrate, and adjusting pH to 4.1.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, the hand wet tissue composition is sprayed on non-woven fabrics in proportion, and then the non-woven fabrics are folded by a folding machine and cut by a circular disc cutter to obtain a semi-finished product, and the semi-finished product is packaged by a packaging machine to obtain the hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 7:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.5% of sodium benzoate, 0.1% of potassium sorbate, 1.0% of gluconolactone, 2.0% of glycerol, 0.002% of tremella polysaccharide, 0.005% of sweet orange peel oil, 0.2% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide is evenly dispersed in glycerin and then added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate and potassium sorbate are dissolved at the temperature of below 40 ℃ according to the conventional process, a reserved part of glycerin is dissolved in orange peel oil, the mixture is added into water after being dissolved, and sodium citrate is added to adjust the pH value to 4.1.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, the hand wet tissue composition is sprayed on non-woven fabrics in proportion, and then the non-woven fabrics are folded by a folding machine and cut by a circular disc cutter to obtain a semi-finished product, and the semi-finished product is packaged by a packaging machine to obtain the hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Example 8:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.5% of sodium benzoate, 0.1% of potassium sorbate, 1.0% of gluconolactone, 2.0% of glycerol, 0.002% of tremella polysaccharide, 0.002% of glycogen, 0.01% of sweet orange peel oil, 0.2% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide is evenly dispersed in glycerin and then added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate and potassium sorbate are dissolved at the temperature of below 40 ℃ according to the conventional process, a reserved part of glycerin is dissolved in orange peel oil, the mixture is added into water after being evenly dissolved, and sodium citrate is added to adjust the pH value to 4.1.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand wet tissue composition is prepared, the hand wet tissue composition is sprayed on non-woven fabrics in proportion, and then the non-woven fabrics are folded by a folding machine and cut by a circular disc cutter to obtain a semi-finished product, and the semi-finished product is packaged by a packaging machine to obtain the hand wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Comparative example 1:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.4% of sodium benzoate, 0.08% of potassium sorbate, 1.0% of glycerol, 0.002% of tremella polysaccharide, 0.3% of citric acid, 0.01% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide is evenly dispersed in glycerol, then added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate and potassium sorbate are dissolved at the temperature of below 40 ℃ according to a conventional process, and citric acid and sodium citrate are added to adjust the pH value to 4.2.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the blending of the wet tissue liquid is finished, spraying the wet tissue liquid on non-woven fabrics in proportion, folding the non-woven fabrics by a folding machine, cutting the non-woven fabrics by a circular disc cutter to finish semi-finished products, and packaging the semi-finished products by a packaging machine to finish the preparation of wet tissue products.
Comparative example 2:
the hand and mouth wet tissue composition comprises the following components in percentage by weight: 0.5% of sodium benzoate, 0.05% of potassium sorbate, 0.5% of gluconolactone, 1.00% of glycerol, 0.002% of tremella polysaccharide, 0.3% of cyclodextrin, 0.23% of sodium citrate and the balance of water.
The preparation method of the hand and mouth wet tissue composition comprises the following steps: the tremella polysaccharide is evenly dispersed in glycerol, then added into a water phase to be heated and dissolved, gluconolactone is dissolved at the high temperature of 70 ℃, then sodium benzoate, potassium sorbate and cyclodextrin are dissolved at the temperature of below 40 ℃ according to the conventional process, and sodium citrate is added to adjust the pH value to 4.3.
The preparation method of the hand and mouth wet tissue comprises the following steps: after the hand-mouth wet tissue composition is prepared, spraying the hand-mouth wet tissue composition on non-woven fabrics in proportion, folding by a folding machine, cutting by a circular disc cutter to obtain a semi-finished product, and packaging by a packaging machine to obtain the hand-mouth wet tissue product. The mass ratio of the non-woven fabric to the wet tissue composition is 1.
Experimental example 1: antibacterial force test
The antibacterial force test method comprises the following steps:
1. sample preparation: and (3) extruding the liquid medicine in the test sample after wearing the PE gloves by both hands, and filtering the extruded liquid into a prepared sterile bottle as the test sample by using a sterile needle filter in a sterile environment.
2. Sample inoculation: accurately weighing 10-20 g of sample (using a sterile syringe to transfer, and adjusting the specific weighing amount according to actual test requirements); adding the inoculum solution into the sample by using a pipette gun according to the proportion of 0.1ml/10g, uniformly mixing and timing;
3. and (3) sample testing: 1ml of the sample (inoculated lysate) was pipetted at the specified sampling time point and added to 9ml of the LP dilution and mixed, this being a 10-fold dilution. Then, 1ml of 10-fold diluent is transferred by a pipette gun and added into 9ml of liquid culture medium to be uniformly mixed and cultured.
The sampling time of different inoculants is referred to the following table (the specific operation is adjusted according to actual conditions):
culturing residual bacteria of the sample: the bacteria are cultured in a 37 ℃ incubator for 1-2 days, and the fungi are cultured in a 25 ℃ incubator for 3-7 days.
4. And (3) judging: and (4) comparing the clarification time of the residual bacteria culture solution of the test sample under the condition that the experiment is effective.
5. The test results were as follows:
and (4) conclusion: as can be seen from the test results in the above table, the gluconolactone-containing hand wipe compositions prepared in examples 2, 4 and 6 of the present application have significant bacteriostatic effects, compared to the gluconolactone-free hand wipe composition of comparative example 1. And with the increase of the content of the gluconolactone, the time for clarifying the residual bacteria of the test sample is shorter, and the bacteriostatic effect of the product is obviously improved, so that the gluconolactone has the function of antisepsis and synergism.
Experimental example 2: smell investigation
The test sample is scored according to the scent preference degree, wherein the score is 1-5, the higher the score is, the more the scent of the sample is preferred, the number of the tested persons is 12, and the scoring records are shown in the following table:
and (4) conclusion: as can be seen from the test results in the table above:
1.100% of the test subjects considered the sweet orange peel oil to have a taste masking effect.
2. As can be seen from the investigation results, the hand wipe compositions containing sweet orange peel oil prepared in examples 2 and 6 to 8 of the present application had better taste masking effects than the hand wipe composition of comparative example 1 containing no taste masking agent and the hand wipe composition of comparative example 2 containing cyclodextrin.
Claims (12)
1. An infant hand and mouth wipe composition characterized in that the wipe composition comprises gluconolactone, sodium benzoate, potassium sorbate and orange peel oil.
2. A baby hand and mouth wipe composition as set forth in claim 1, wherein the wipe composition comprises, by weight, gluconolactone 0.10-2.00%, sodium benzoate 0.10-0.50%, potassium sorbate 0.01-0.2%, and orange peel oil 0.001-0.1%.
3. A baby hand and mouth wipe composition as set forth in claim 1, wherein the wipe composition comprises, by weight, gluconolactone 0.50-1.00%, sodium benzoate 0.30-0.50%, potassium sorbate 0.05-0.10%, and orange peel oil 0.001-0.01%.
4. The wet wipe infant hand composition of claim 1, wherein the wet wipe composition further comprises one or more of a polyol, a polysaccharide, glycogen, a pH adjuster, and a chelating agent.
5. The infant hand and mouth wipe composition of claim 4, wherein the polyol is selected from the group consisting of glycerin or propylene glycol.
6. The infant hand-mouth wipe composition according to claim 4, wherein the polysaccharide is selected from glycogen, tremella polysaccharide, sodium hyaluronate, algal polysaccharide, or rhamnose.
7. The wet wipe infant hand towel composition of claim 4, wherein the glycogen is corn-derived nano-glycogen.
8. The wet wipe infant hand composition according to claim 4, wherein the pH adjusting agent is selected from the group consisting of citric acid, sodium citrate, tartaric acid, malic acid, lactic acid, potassium citrate, disodium hydrogen phosphate or sodium bicarbonate.
9. The wet wipe composition for infants according to claim 1, wherein the wet wipe composition comprises, by weight, 1.00-10.00% of glycerin, 0.10-2.00% of gluconolactone, 0.10-0.50% of sodium benzoate, 0.01-0.2% of potassium sorbate, 0.001-0.1% of tremella polysaccharide, 0.001-0.1% of glycogen, 0.001-0.1% of sweet orange peel oil, 0.01-0.30% of citric acid, 0.01-0.50% of sodium citrate, and the balance of water.
10. The wet wipe composition for infants according to claim 9, wherein the wet wipe composition comprises, by weight, 1.00 to 3.00% of glycerin, 0.50 to 1.00% of gluconolactone, 0.30 to 0.50% of sodium benzoate, 0.05 to 0.10% of potassium sorbate, 0.001 to 0.01% of tremella polysaccharide, 0.001 to 0.01% of glycogen, 0.001 to 0.01% of sweet orange peel oil, 0.02 to 0.1% of citric acid, 0.20 to 0.40% of sodium citrate, and the balance of water.
11. A wet wipe for the hand and mouth of an infant, characterized in that the wet wipe comprises the wet wipe composition of any one of claims 1 to 9 and a nonwoven fabric containing the wet wipe composition.
12. The wet wipe for hands and mouths according to claim 11, wherein the mass ratio of the non-woven fabric and the wet wipe composition is 1.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210965581.7A CN115350120A (en) | 2022-08-12 | 2022-08-12 | Hand-mouth wet tissue composition and wet tissue for infants |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210965581.7A CN115350120A (en) | 2022-08-12 | 2022-08-12 | Hand-mouth wet tissue composition and wet tissue for infants |
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| CN115350120A true CN115350120A (en) | 2022-11-18 |
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| CN109563454A (en) * | 2016-06-22 | 2019-04-02 | 伦萨公司 | Antiseptic composition for wet wipe |
| CN111700812A (en) * | 2020-06-24 | 2020-09-25 | 玮格沃德贸易有限公司 | Hydrophilic moisture mask |
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| CN103919689A (en) * | 2014-03-20 | 2014-07-16 | 金红叶纸业集团有限公司 | Wet tissue emulsion, wet tissue and preparation method of wet tissue |
| CN109563454A (en) * | 2016-06-22 | 2019-04-02 | 伦萨公司 | Antiseptic composition for wet wipe |
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