CN115350098B - Instant silver polyacrylate fluoride caries-preventing paste, using method and tool - Google Patents
Instant silver polyacrylate fluoride caries-preventing paste, using method and tool Download PDFInfo
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- CN115350098B CN115350098B CN202210896988.9A CN202210896988A CN115350098B CN 115350098 B CN115350098 B CN 115350098B CN 202210896988 A CN202210896988 A CN 202210896988A CN 115350098 B CN115350098 B CN 115350098B
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- polyacrylic acid
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- 208000002925 dental caries Diseases 0.000 title claims abstract description 78
- 229910052709 silver Inorganic materials 0.000 title claims description 17
- 239000004332 silver Substances 0.000 title claims description 17
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims description 16
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims description 12
- 229920000058 polyacrylate Polymers 0.000 title claims description 12
- 238000000034 method Methods 0.000 title abstract description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 54
- REYHXKZHIMGNSE-UHFFFAOYSA-M silver monofluoride Chemical compound [F-].[Ag+] REYHXKZHIMGNSE-UHFFFAOYSA-M 0.000 claims abstract description 54
- 229940096017 silver fluoride Drugs 0.000 claims abstract description 49
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 45
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 44
- 230000002265 prevention Effects 0.000 claims abstract description 42
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002494 Zein Polymers 0.000 claims abstract description 13
- 239000005019 zein Substances 0.000 claims abstract description 13
- 229940093612 zein Drugs 0.000 claims abstract description 13
- KAZSKMJFUPEHHW-UHFFFAOYSA-N (2E)-3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hdyroxyphenyl)-2-propen-1-one Natural products COC1=CC(O)=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-UHFFFAOYSA-N 0.000 claims abstract description 10
- IUCVKTHEUWACFB-UHFFFAOYSA-N Licochalcone A Natural products COC1=CC=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 IUCVKTHEUWACFB-UHFFFAOYSA-N 0.000 claims abstract description 10
- KAZSKMJFUPEHHW-DHZHZOJOSA-N Licochalcone A Chemical compound COC1=CC(O)=C(C(C)(C)C=C)C=C1\C=C\C(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-DHZHZOJOSA-N 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims description 45
- 238000001125 extrusion Methods 0.000 claims description 40
- 238000007789 sealing Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 15
- 238000003860 storage Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 8
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 6
- 229940043234 carbomer-940 Drugs 0.000 claims description 6
- 230000005484 gravity Effects 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 239000007779 soft material Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 230000007794 irritation Effects 0.000 abstract description 4
- 150000004676 glycans Chemical class 0.000 abstract description 3
- 230000003239 periodontal effect Effects 0.000 abstract description 3
- 229920001282 polysaccharide Polymers 0.000 abstract description 3
- 239000005017 polysaccharide Substances 0.000 abstract description 3
- DRDRYGIIYOPBBZ-XBXARRHUSA-N Licochalcone B Natural products COC1=C(O)C(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1 DRDRYGIIYOPBBZ-XBXARRHUSA-N 0.000 abstract description 2
- WBDNTJSRHDSPSR-UHFFFAOYSA-N Licochalcone C Natural products C1=CC(O)=C(CC=C(C)C)C(OC)=C1C=CC(=O)C1=CC=C(O)C=C1 WBDNTJSRHDSPSR-UHFFFAOYSA-N 0.000 abstract description 2
- 229930187586 licochalcone Natural products 0.000 abstract description 2
- 238000005461 lubrication Methods 0.000 abstract description 2
- 239000011505 plaster Substances 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000047 product Substances 0.000 description 46
- 239000000499 gel Substances 0.000 description 32
- 238000011161 development Methods 0.000 description 11
- 230000018109 developmental process Effects 0.000 description 11
- FBHUUNIZBXAIQE-UHFFFAOYSA-M silver azanide fluoride Chemical compound [NH2-].[NH2-].[F-].[Ag+] FBHUUNIZBXAIQE-UHFFFAOYSA-M 0.000 description 11
- 239000002253 acid Substances 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- 230000000675 anti-caries Effects 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 210000004513 dentition Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005530 etching Methods 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 230000002028 premature Effects 0.000 description 4
- 230000036346 tooth eruption Effects 0.000 description 4
- -1 Silver ions Chemical class 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 229940023462 paste product Drugs 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001878 scanning electron micrograph Methods 0.000 description 3
- 239000003566 sealing material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000005239 tubule Anatomy 0.000 description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 210000004913 chyme Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 235000006694 eating habits Nutrition 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 238000000016 photochemical curing Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- FJOLTQXXWSRAIX-UHFFFAOYSA-K silver phosphate Chemical group [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O FJOLTQXXWSRAIX-UHFFFAOYSA-K 0.000 description 2
- 229940019931 silver phosphate Drugs 0.000 description 2
- 229910000161 silver phosphate Inorganic materials 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 229910052712 strontium Inorganic materials 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010082714 Silver Proteins Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- UYEKHXLXNOJAAG-UHFFFAOYSA-N azanium silver fluoride Chemical compound [Ag].[F-].[NH4+] UYEKHXLXNOJAAG-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
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- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
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- 150000004985 diamines Chemical class 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
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- 238000011068 loading method Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
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- 210000000214 mouth Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 125000004354 sulfur functional group Chemical group 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dentistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a ready-to-use polyacrylic acid silver fluoride caries prevention paste, a using method and a tool thereof; the instant polyacrylic acid silver fluoride caries preventing plaster is calculated according to the weight of the finished product, and the raw materials with the following weight proportion are needed: 5-10 parts of dimethyl sulfoxide, 35-40 parts of silver fluoride, 10-15 parts of polyacrylic acid, 15-20 parts of glycerol, 3-5 parts of zein and 0.1-1 part of licochalcone A; in the preparation process, proper amount of absolute ethyl alcohol is needed to be used as a solvent of the whole gel system; glycerol and dimethyl sulfoxide are used to alter gel lubrication and stability; zein is used to load licochalcone and adjust pH to form a uniform gel system. The invention adopts zein and Chinese medicinal polysaccharide, improves periodontal microenvironment, and has better antibacterial repair effect. And the irritation caused by amine is reduced, the operability is enhanced, and the shelf life of the product is longer.
Description
Technical Field
The invention relates to a caries preventing paste and a using method and a tool, in particular to a ready-to-use polyacrylic acid silver fluoride caries preventing paste and a using method and a tool.
Background
The pit and sulcus sealing means that the tooth tissue is not damaged, the pit and sulcus sealing material is coated on the pit and sulcus point gaps of the occlusal surface and the buccal surface of the dental crown, and when the pit and sulcus sealing material flows into and permeates into the pit and sulcus, the pit and sulcus sealing material is solidified and hardened to form a protective barrier which covers the pit and sulcus, and the caries causing bacteria and acid metabolites can be prevented from corroding the tooth, so that the method for preventing the pit and sulcus caries is achieved. Pit and fissure closure is a painless, atraumatic method that has been used internationally for over 50 years.
Existing methods of socket closure require several steps of cleaning teeth, etching, rinsing and drying, applying a sealer, and curing. It is emphasized, however, that the pit closure requires the manipulation by a skilled person and the necessary instrumentation. If the operation of the acid etching agent is excessively large or small or saliva pollution occurs in the acid etching process in the traditional mode, pit sealing failure can be caused, and the caries risk is increased. The area of the acid etchant coating cannot be too large, otherwise the gums may be eroded; in addition, care should be taken to isolate moisture so as to prevent tongue movement from touching and corrosion caused by acid etching agents. The suitability of the etched dental mask body is observed empirically, and most of the dental mask body needs to be repeatedly operated. The classical conditions that need to be ensured are too many and the operation needs to be careful. Too much accumulation is easy to cause occlusion change, which is unfavorable for occlusion reconstruction and growth.
Silver ammonia fluoride (Silver Diamine Fluoride, SDF) was first proposed in the last 70 th century and has been increasingly investigated for the treatment of dentinal hypersensitivity, anticaries and anticaries; the earliest development of experiments and clinical researches of silver ammonia fluoride solution in the oral cavity in China can be traced to the 80 th century, but no deeper product level research and development exists. While until 2014, the U.S. food and drug administration did not approve SDF for treatment of adult tooth sensitivity, the european and american market did not develop SDF-related products; 10 months 2018, the american society of dentistry (ADA) issued clinical guidelines for non-restorative treatment of dental caries in children and adults, indicating that this non-invasive treatment with silver ammonia fluoride solution can effectively stop or remineralize caries lesions in crowns and roots of children and adults, and also attracts attention of domestic research teams.
Silver ammonium fluoride solutions are transparent liquids containing silver and fluoride, are pale blue in color, have an ammonia-water-irritating odor, and are commercially available in the market generally containing 29% -32% silver fluoride and 8% -10% ammonia. Studies have shown that silver ammonia fluoride solution can penetrate 25 μm in enamel and up to 200-300 μm in dentin.
Silver ions in the silver ammonia fluoride solution can form silver protein, so that the silver ammonia fluoride solution has a sealing effect on dentinal tubules and can isolate external physical and chemical stimulus, thereby achieving the effect of dentinal desensitization; occlusion of dentinal tubules also blocks the passage of bacteria and acidic products.
Fluoride ions in the silver ammonia fluoride solution can be combined with hydroxyapatite which is a main component in teeth to form fluoridized apatite, and the fluoridized apatite structure is more acid-resistant and insoluble, so that the acid-resistant performance of tooth tissues is greatly improved, and caries is prevented from further occurrence and development. In the reaction process of fluoride ions and hydroxyapatite, the formed by-product is silver phosphate, and the silver phosphate can react with sulfur groups and be combined with amino acid and nucleic acid after being substituted, so that bacteria lose metabolism and reproduction capacity, and the effect of killing the bacteria is achieved.
In a word, the silver ammonia fluoride solution inhibits the demineralization of hard tissues of teeth and the degradation of collagen tissues through the sterilization effect, dentin tubule sealing effect, ion replacement effect and the like, promotes the remineralization process of the tooth tissues, and effectively achieves the aims of dentin desensitization and preventing the occurrence and development of dental caries. In the prior art, enterprises begin to research the application of silver ammonia fluoride in preventing dental caries.
However, because the silver ammonia fluoride in the prior art contains ammonia, certain irritation is caused in the use process, and discomfort is brought to users. There is a need to develop new materials for more gently and effectively preventing caries and improving product competitiveness.
Disclosure of Invention
The invention aims at solving the problems in the prior art and provides a ready-to-use polyacrylic acid silver fluoride caries prevention paste, and a using method and a tool thereof.
The aim of the invention is achieved by the following technical scheme:
the instant polyacrylic acid silver fluoride caries prevention paste is calculated according to the weight of the finished product, and the following raw materials in parts by weight are needed:
10-15 parts of polyacrylic acid;
15-20 parts of glycerol;
3-5 parts of zein;
0.1-1 part of licochalcone A;
5-10 parts of dimethyl sulfoxide (DMSO);
35-40 parts of silver fluoride (AgF);
in the preparation process, a proper amount of any solution which has no influence on the reaction is required to be used as a solvent of the whole gel system; calculating the dosage of the solvent according to the weight parts of the raw materials and the concentration requirement of the solvent; the pH was adjusted to form a homogeneous gel system.
Preferably, the following synthetic steps are employed:
and pouring the polyacrylic acid gel solution A into the silver fluoride solution B in a sealing manner, and stirring and mixing to obtain the instant polyacrylic acid silver fluoride caries prevention paste.
In one aspect, the polyacrylic acid gel solution A is prepared as follows:
preparing 75% -85% alcohol glycerol solution by weight concentration; sequentially adding zein, licochalcone A and polyacrylic acid into the alcohol glycerol solution, and fully mixing to prepare the polyacrylic acid silver fluoride solution A.
On the other hand, the silver fluoride solution B was prepared as follows:
in a vacuum environment, dimethyl sulfoxide and silver fluoride are added into deionized water to prepare the product with the specific gravity of 3.9-4.1g/mL.
The invention relates to a method and a tool for using instant polyacrylic acid silver fluoride dental caries prevention paste, wherein the instant polyacrylic acid silver fluoride dental caries prevention paste is packaged into a single dental caries prevention capsule by adopting a soft film, when the instant polyacrylic acid silver fluoride dental caries prevention paste is used, a smearing tool is sleeved outside the dental caries prevention capsule, the smearing tool comprises a cylindrical body provided with a hollow cavity, the rear end of the cylindrical body is opened, the front end of the cylindrical body is connected with a soft brush piece, and the soft brush piece is communicated with the dental caries prevention capsule in the hollow cavity through a flow guider.
The invention is further arranged that the front end of the cylindrical body is provided with a front mounting hole for penetrating the soft brush piece and a threaded hole positioned at the rear end of the front mounting hole, the threaded hole is connected with the deflector, the deflector is also provided with a backward extending duct part, and the rear end of the duct part is pointed so as to break through the front end of the caries prevention capsule.
The invention is further arranged that the cylindrical body comprises a front section part and a rear section part, wherein the front section part and the rear section part are in threaded connection or snap connection, and the front end of the front section part is conical; the rear end of the soft brush piece is a clamping part, and the front end of the soft brush piece is in a circular arc flat shape; the extrusion port is arranged on one side or two sides of the flat shape; the device also comprises a front end outlet positioned at the front end of the flat shape, and the front end outlet is communicated with the inner flow passage through a concave storage passage.
The invention is further provided that the rear end of the cylindrical body is opened and is connected with an extrusion rod penetrating into the hollow cavity, and the caries prevention capsule arranged in the hollow cavity and an internal runner arranged in the soft brush piece are communicated through the flow guider; the surface of the soft brush piece is provided with a plurality of extrusion ports communicated with the inner runner.
The invention is further arranged that the extrusion rod comprises a hollow pipe and a concave end cover which is arranged at the front end of the hollow pipe and made of soft materials, so as to adapt to the shape of the caries prevention capsule; a rear push rod extending backwards is arranged in the hollow tube.
The invention is further arranged that the outer side of the rear end of the extrusion rod is provided with a middle convex outer ring part, and the outer side of the rear end of the rear push rod is provided with a rear convex outer ring part; the rear bulge outer ring part is provided with a plurality of support rod parts in a forward extending mode, and the inner side of the front end of each support rod part is provided with a guide inclined plane and a stop protruding part for stopping the middle bulge outer ring part.
Compared with the prior art, the invention has the beneficial effects that: the instant polyacrylic acid silver fluoride caries prevention paste of the invention adopts the addition of zein and Chinese medicine polysaccharide (licochalcone A), improves periodontal microenvironment and ensures better antibacterial repair effect. And the irritation caused by ammonia is reduced, the operability is enhanced, and the shelf life of the product is longer. Can be used as a tooth protecting product, can be smeared on the surface of young permanent teeth to form a protecting film on the surface of the teeth, can reduce the damage of the teeth, and can also be used as a material for repairing the teeth.
The invention can be used as a pit and fissure sealing agent, is a protection product for newly erupted new permanent teeth, mainly uses a pit and fissure structure for sealing the development deep pit and fissure structure of the deep part of young permanent teeth, and can isolate the deep structure in the pit and fissure from exchanging substances with the outside, balancing acid and alkali, fixing bacteria and the like. Can reduce premature caries or deficiency of young permanent teeth caused by adverse effects (such as poor eating habit, poor oral hygiene protection consciousness, etc.) during growth, and premature effect on the development of the jaw and face of children. The natural development and formation of the upper dentition and the lower dentition are facilitated; also helps in the proper way of chewing food intake, thereby helping to increase the digestive efficiency of chyme entering the human digestive system. The product can replace a series of related products (laggard products) in China at present, the output of the product breaks through international banning, and the protection effect of young permanent teeth is obviously improved; reducing the incidence rate of caries. The product is different from foreign products used at home at present and similar products produced by the existing domestic manufacturers. The product used at present is a photo-curing resin product, the finished product is physically bonded, the product is chemically bonded with the tooth surface, a new and harder structure is formed between the product and the tooth surface and between the product and the hydroxyapatite, and the product has no residue and bonding edge on the tooth surface, which is not beneficial to the adhesion of bacterial plaques; the residual binding product remains in the deep part of the development pit of the tooth, plays a role in continuous antibacterial, and has no other residual product.
The invention also discloses a smearing tool for preventing decayed tooth and paste, which takes the cylindrical body with the hollow cavity as a holding part, and also adopts the extrusion rod for extruding and preventing decayed tooth, when smearing, the extrusion rod can be slightly forced, and gel (namely, the polyacrylic acid silver fluoride paste for preventing decayed tooth) can be continuously provided for the soft brush piece, so that the smearing tool is convenient to use, saves time and increases good experience for users. The concave end cover and the arc convex tip shaped rear push rod which are made of soft materials are further adopted, so that the arc convex tip shaped rear push rod can eject out of the concave end cover when in final extrusion, gel in the capsule can be extruded to a soft brush piece to the greatest extent, and the capsule can be used to the greatest extent. The concave storage channel is adopted, and when the forefront end of the soft brush piece is required to be used, gel stored in the concave storage channel can flow out of the front end outlet rapidly, so that the application by a user is facilitated. The supporting rod part with the stop protruding part is further adopted, so that in the extrusion process, the extrusion rod is pushed first, and then the pushing of the rear push rod is automatically switched through the action of the supporting rod part. The rubber ring can be further added, when the front half part of the capsule is extruded, the rubber ring is connected to the first-stage protruding outer ring part from the rear protruding outer ring part, and when the rear half part of the capsule is extruded, the rubber ring is connected to the second-stage protruding outer ring part from the rear protruding outer ring part, so that the extrusion force born by the capsule is kept in a reasonable range, errors are reduced, and convenience in use is improved.
Drawings
FIG. 1A is a schematic illustration of the method of using the instant silver polyacrylate fluoride anti-caries paste of the present invention;
FIG. 1B is an SEM image of a ready-to-use silver polyacrylate fluoride anti-caries paste product directly applied to a tooth surface after cleaning according to example 2 of the present invention;
FIG. 1C is a layered image of an EDS of example 3 of the instant silver polyacrylate fluoride caries prevention paste of the present invention;
FIG. 1D is a spectral analysis of the spectral 77 region of FIG. 1C;
FIG. 2 is a cross-sectional block diagram and partial enlarged view of an embodiment of the applicator of the present invention;
fig. 3 is an enlarged view of a portion a in fig. 2;
fig. 4 is an enlarged view of a portion B in fig. 2;
fig. 5 is a cross-sectional structural view and a partial enlarged view of a further embodiment of the applicator of the present invention.
Reference numerals of fig. 2-5
P caries prevention capsule S smearing tool
10. Hollow cavity of tubular body 100
10A front section 10B rear section
101. Front mounting hole 102 threaded hole
105. Two-stage protrusion outer ring part of hook protrusion 108
109. First-stage convex outer ring part
20. Raised outer ring portion in extrusion stem 219
21. Hollow tube 22 indent end cover
30. Inner flow passage of soft brush piece 31
307. Front outlet of concave storage channel 308
318. Narrow portion of outer slope 319
32. Extrusion port 39 clamping part
40. Conduit portion of deflector 41
50. Rear end face of rear push rod 500
501. Guide slope of transverse groove 581
582. Stop boss 58 supporting rod portion
59. Rear convex outer ring part
60. Inner inclined surface of adjusting nut 61
Detailed Description
The technical solutions of the present invention will be clearly and completely described below by the following examples, which are only some of the embodiments of the present invention, but not all of them. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be understood that the terms "comprises" and "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the embodiments of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of embodiments of the invention. As used in the specification of the embodiments of the invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
The instant polyacrylic acid silver fluoride caries prevention paste is calculated according to the weight of the finished product, and the following raw materials in parts by weight are needed:
10-15 parts of polyacrylic acid (preferably carbomer 940);
15-20 parts of glycerol;
3-5 parts of zein;
0.1-1 part of licochalcone A;
5-10 parts of dimethyl sulfoxide (DMSO);
35-40 parts of silver fluoride (AgF);
in the preparation process, preferably, a proper amount of absolute ethyl alcohol is used as a solvent of the whole gel system; glycerol and dimethyl sulfoxide (DMSO) for altering gel lubrication and stability; zein is used for loading licochalcone; adjusting the pH to form a homogeneous gel system; the solvent dosage is calculated according to the weight parts of the raw materials and the concentration requirement of the solvent.
Example 1
The instant polyacrylic acid silver fluoride caries prevention paste is prepared by the following processing steps:
and pouring the polyacrylic acid gel solution A into the silver fluoride solution B in a sealing manner, and stirring and mixing to obtain the instant polyacrylic acid silver fluoride caries prevention paste.
The processing steps of the polyacrylic acid gel solution A comprise:
step one, adding glycerol into absolute ethanol to prepare an alcohol glycerol solution with the glycerol weight concentration of 75% -85%;
step two, adding zein into the alcohol glycerol solution, and fully and uniformly stirring; adding licochalcone A, and stirring thoroughly;
step three, adding polyacrylic acid (preferably, carbomer 940) into the mixture, stirring the mixture fully and uniformly by magnetic stirring, and preparing Cheng Kabo mu-licochalcone alcohol gel to obtain a standby solution A;
the silver fluoride solution B processing steps comprise:
firstly, putting deionized water into a vacuum kettle, connecting negative pressure, and discharging oxygen dissolved in water; adding dimethyl sulfoxide (DMSO), and adjusting pH to 9-10;
adding silver fluoride (AgF) into the solution to prepare solution B with the specific gravity of 3.9-4.1g/mL, blowing or shaking the solution B until the solution B is dissolved when the solution B is insoluble, and pouring the solution B into a vacuum kettle in a sealing mode for standby;
and finally, pouring the solution A into the solution B in a sealing manner, slowly mixing while stirring, and fully and uniformly stirring to obtain the instant polyacrylic acid silver fluoride caries prevention paste, which is also called silver fluoride-licochalcone A working gel. The method is suitable for small-batch production.
Table 1 below (in grams of weight) is an example of five different ratios in example 1.
FIG. 2 is an SEM image of a ready-to-use silver polyacrylate fluoride anti-caries paste product of the present invention made according to example 1-1 directly after tooth surface cleaning.
Example 2
The instant polyacrylic acid silver fluoride caries preventing plaster is prepared by the following processing steps:
and pouring the polyacrylic acid gel solution A into the silver fluoride solution B in a sealing manner, and stirring and mixing to obtain the instant polyacrylic acid silver fluoride caries prevention paste.
The processing steps of the polyacrylic acid gel solution A comprise:
step one, adding glycerol into absolute ethanol to prepare an alcohol glycerol solution with the glycerol weight concentration of 75% -85%;
step two, adding zein into the alcohol glycerol solution, and fully and uniformly stirring; adding licochalcone A, and stirring thoroughly;
step three, adding polyacrylic acid (preferably carbomer 940), stirring by magnetic force, and preparing Cheng Kabo mu-licochalcone alcohol gel to obtain a standby solution A;
the silver fluoride solution B processing steps comprise:
adding dimethyl sulfoxide (DMSO) into 10% ammonia water, adding silver fluoride (AgF) to prepare solution B with specific gravity of 3.7-3.9g/mL, and pouring into a vacuum kettle in a sealing manner for standby;
and finally, pouring the solution A into the solution B in a sealing manner, slowly mixing while stirring, and fully and uniformly stirring to obtain the instant polyacrylic acid silver fluoride caries prevention paste, which is also called silver fluoride-licochalcone A working gel. This method is suitable for mass production.
In other embodiments, magnetic stirring may be replaced by ultrasonic stirring.
Table 2 below (in kilograms) is an example of five different ratios in example 2.
Example 3
The polyacrylic acid (carbomer 940) in the above example was changed to a chondroitin sulfate strontium freeze-dried hydrogel to prepare a silver fluoride caries prevention paste. In this example, because carbomers are not used and polyacrylic acid is absent, it is called a silver fluoride anti-caries paste directly or a strontium chondroitin sulfate lyophilized hydrogel silver fluoride anti-caries paste. The microstructure of one embodiment is shown in fig. 1C (EDS layered image diagram) and fig. 1D (energy spectrum analysis diagram). The functions and effects are similar to those of embodiment 1 and embodiment 2. The specific elemental analysis is as follows:
table 3: element analysis table
Table 4: element proportion table
| Element(s) | wt％ | wt％Sigma |
| C | 3.35 | 0.52 |
| O | 14.15 | 1.39 |
| F | 3.31 | 0.73 |
| Sr | 0.00 | 0.00 |
| Ag | 79.19 | 1.94 |
| Total amount: | 100.00 |
example 4
According to the application method and tool of the instant polyacrylic acid silver fluoride dental caries prevention paste, according to the safe consumption of fluorine element, the instant polyacrylic acid silver fluoride dental caries prevention paste is packaged into a single dental caries prevention capsule by using a soft film, and the packaging volume of the single capsule is 0.25-0.5mL; when in use, one end is crushed to allow the gel to flow out and cover the tooth groove or the tooth surface, and the gel is uniformly smeared by a brushing tool for 5-8 minutes so as to volatilize the alcohol completely. See fig. 1A. In the figure, 1 is a compression needle cylinder, 2 is a detachable brush head, and 3 is a medicine bullet (namely a gel capsule, namely the instant polyacrylic acid silver fluoride caries prevention paste).
FIG. 1B is an SEM image of a ready-to-use silver polyacrylate fluoride anti-caries paste product of the present invention directly applied after tooth surface cleaning.
Example 5
According to the application method and tool of the instant polyacrylic acid silver fluoride dental caries prevention paste, according to the safe consumption of fluorine element, the instant polyacrylic acid silver fluoride dental caries prevention paste is packaged into a single dental caries prevention capsule by using a soft film, and the packaging volume of the single capsule is 0.25-0.5mL; when in use, the caries preventing capsule is filled into a hollow cavity arranged on the smearing tool; the smearing tool comprises a cylindrical body, the rear end of the cylindrical body is opened, the front end of the cylindrical body is connected with a soft brush piece, and the cylindrical body is communicated with the caries prevention capsule in the hollow cavity through a flow director. See fig. 2 and the following description for a specific structure of the application tool.
Example 6
As shown in fig. 2, the caries preventing paste applying tool S of the present invention includes a cylindrical body 10 having a hollow cavity 100, an extrusion rod 20 penetrating into the hollow cavity 100 is opened at the rear end of the cylindrical body 10, a soft brush sheet 30 is coupled to the front end of the cylindrical body, and a caries preventing capsule P provided in the hollow cavity 100 is communicated with an inner flow path 31 provided in the soft brush sheet 30 through a fluid director 40 provided; the surface of the soft brush piece 30 is provided with a plurality of extrusion ports 32 communicated with the inner runner 31; in use, the extrusion rod 20 is slowly pushed forward to act on the caries preventing capsule P, and gel in the caries preventing capsule P flows to the inner flow path 31 through the flow guider 40.
More specifically, the front end of the extrusion rod 20 is embedded with an inwardly concave end surface to adapt to the shape of the caries preventing capsule P; the front end of the tubular body 10 is provided with a front mounting hole 101 for passing through the soft brush piece 30, and a threaded hole 102 positioned at the rear end of the front mounting hole 101, the threaded hole 102 is connected with a deflector 40, the deflector 40 is also provided with a rearwardly extending duct portion 41, the rear end of the duct portion 41 is pointed, and the front end of the caries preventing capsule P can be pierced in the forward moving process of the caries preventing capsule P.
More specifically, the cylindrical body 10 includes a front section 10A and a rear section 10B, the front section 10A and the rear section 10B are screwed or snapped, and the front end of the front section 10A is conical, which is convenient for a user to operate while reducing the volume. The rear end of the soft brush piece 30 is provided with a clamping part 39 (the clamping part 39 passes through the front mounting hole 101 from back to front during mounting, the front mounting hole 101 is stepped, and the front end is in a circular arc flat shape; the extrusion openings are arranged on two sides of the flat shape (also can be arranged on one side below, and the extrusion openings do not need to be turned 180 degrees when in use); and a front outlet 308 at the front end of the flat shape, the front outlet 308 being in communication with the inner flow path 31 through a concave reservoir 307. The concave storage channel 307 is of a concave structure with two small ends and a large middle part, and the middle part is positioned below during storage; when the front end outlet 308 is needed to discharge gel, the tool is turned 180 degrees, the middle part of the concave storage channel 307 is positioned above, and the gel in the concave storage channel 307 can flow to the front end outlet 308 at a higher speed under the action of gravity.
More specifically, the extrusion rod 20 includes a hollow tube 21 and a concave end cap 22 (constituting the aforementioned concave end face) provided at the front end of the hollow tube 21 and made of a soft material; a rear push rod 50 extending backwards is arranged in the hollow tube 21, and the front end of the rear push rod 50 is in a circular arc convex pointed shape.
More specifically, two front convex outer ring parts, namely a first-stage convex outer ring part 109 and a second-stage convex outer ring part 108, are arranged on the outer side of the rear section of the tubular body 10, and a middle convex outer ring part 219 is arranged on the outer side of the rear end of the hollow tube 21 of the extrusion rod 20; the rear outer side of the rear end of the rear push rod 50 is provided with a rear convex outer ring part 59; the rear convex outer ring portion 59 is extended forward by 3-6 support rod portions 58, and the front end inner side of the support rod portion 58 is provided with a guide slope 581 and a stop boss 582 for stopping the middle convex outer ring portion 219. The rear push rod 50 is made of plastic material with a certain deformation amount, and the support rod part 58 integrally formed with the rear push rod has a certain elasticity.
In use, during the initial extrusion, the supporting rod portion 58 of the rear push rod 50 is kept at a normal position, and the stop boss 582 thereof abuts against the convex outer ring portion 219, so that the thrust of the initial extrusion is transmitted to the extrusion rod 20, and the caries preventing capsule P is uniformly stressed and is not easy to deform under the action of the concave end surface, thereby reducing the possibility of gel overflowing from the front end puncture. When the guide slope 581 of the front end of the supporting rod portion 58 is in contact with the outer edge of the primary convex outer ring portion 109, the front end of the supporting rod portion 58 is gradually opened outwardly by the forward pushing force, the stop convex portion 582 is gradually separated from the middle convex outer ring portion 219, the front end of the pressing rod 20 is fixed after reaching the limit position, and the pushing force acting on the rear end face of the rear push rod 50 causes the rear push rod 50 to move forward, so that the secondary pressing is realized. The secondary extrusion process has the advantage that the front end of the extrusion rod adopts the concave end face, so that the front end of the extrusion rod has a good positioning effect when the caries preventing capsule P is installed, and is easy to align with the center position, so that the position of the flow director 40 for piercing the caries preventing capsule P is positioned at a relatively center position, the caries preventing capsule P is uniformly stressed in the extrusion process, overflow or leakage is not generated, and the use efficiency is greatly improved.
The smearing tool of the caries preventing paste can be used for smearing the caries preventing paste of the instant polyacrylic acid silver fluoride, and can also be used for smearing other caries preventing pastes or other gel type products.
In other embodiments, a rubber ring can be further added, when the front half part of the capsule is extruded, the rubber ring is connected to the first-stage protruding outer ring part from the rear protruding outer ring part, and when the rear half part of the capsule is extruded, the rubber ring is connected to the second-stage protruding outer ring part from the rear protruding outer ring part, so that the extrusion force born by the capsule is kept within a reasonable range, errors are reduced, and convenience in use is improved. Because of the tension of the rubber ring, a user does not need to press hard in the using process and only needs to pay attention to smearing. Because of the tension of the rubber ring, excessive use is possible. Therefore, it is also possible to adopt the structure of another embodiment of fig. 5, wherein a narrow portion 319 is provided on the inner flow path 31 of the soft brush piece 30, and an outer inclined surface 318 is provided on the outer side corresponding to the narrow portion 319; the adjusting nut 60 with the inner inclined surface 61 is further adopted, the adjusting nut 60 is in threaded connection with the front end of the front section 10A, the adjusting nut 60 moves back and forth, the effective passing area of the narrow part 319 is adjusted through the functions of the inner inclined surface 61 and the outer inclined surface 318, so that the flow rate of gel passing through the narrow part 319 is changed, the gel flow rate during use is adjusted, a user can work according to the working rhythm of the user, the using amount of the gel is saved to the greatest extent, and the cost is saved for the user. Also shown in fig. 5 is a hooking protrusion 105 for hooking a rubber band (not shown), and a lateral groove 501 for embedding the rubber band is provided at a rear end surface 500 of the rear push rod 50. The two ends of the rubber ring are respectively hung on the hook bulges 105, and the middle part of the rubber ring bypasses the rear end face 500 of the rear push rod 50 and is embedded into the transverse groove 501.
In conclusion, the instant silver polyacrylate caries preventing paste adopts the addition of zein and Chinese medicine polysaccharide (licochalcone A), improves periodontal microenvironment, and has better antibacterial repairing effect. And the irritation caused by ammonia is reduced, the operability is enhanced, and the shelf life of the product is longer. Can be used as a tooth protecting product, can be smeared on the surface of young permanent teeth to form a protecting film on the surface of the teeth, can reduce the damage of the teeth, and can also be used as a material for repairing the teeth. The invention ensures that the storage and transportation of the silver ammonia fluoride are more stable-!
The invention can be used as a pit and fissure sealing agent, is a protection product for newly erupted new permanent teeth, mainly uses a pit and fissure structure for sealing the development deep pit and fissure structure of the deep part of young permanent teeth, and can isolate the deep structure in the pit and fissure from exchanging substances with the outside, balancing acid and alkali, fixing bacteria and the like. Can reduce premature caries or deficiency of young permanent teeth caused by adverse effects (such as poor eating habit, poor oral hygiene protection consciousness, etc.) during growth, and premature effect on the development of the jaw and face of children. The natural development and formation of the upper dentition and the lower dentition are facilitated; also helps in the proper way of chewing food intake, thereby helping to increase the digestive efficiency of chyme entering the human digestive system. The product can replace a series of related products (laggard products) in China at present, the output of the product breaks through international banning, and the protection effect of young permanent teeth is obviously improved; reducing the incidence rate of caries. The product is different from foreign products used at home at present and similar products produced by the existing domestic manufacturers. The product used at present is a photo-curing resin product, the finished product is physically bonded, the product is chemically bonded with the tooth surface, a new and harder structure is formed between the product and the tooth surface and between the product and the hydroxyapatite, and the product has no residue and bonding edge on the tooth surface, which is not beneficial to the adhesion of bacterial plaques; the residual binding product remains in the deep part of the development pit of the tooth, plays a role in continuous antibacterial, and has no other residual product.
The invention also discloses a smearing tool for preventing decayed tooth and paste, which takes the cylindrical body with the hollow cavity as a holding part, and also adopts the extrusion rod for extruding and preventing decayed tooth, when smearing, the extrusion rod can be slightly forced, and gel (namely, the polyacrylic acid silver fluoride paste for preventing decayed tooth) can be continuously provided for the soft brush piece, so that the smearing tool is convenient to use, saves time and increases good experience for users. The concave end cover and the arc convex tip shaped rear push rod which are made of soft materials are further adopted, so that the arc convex tip shaped rear push rod can eject out of the concave end cover when in final extrusion, gel in the capsule can be extruded to a soft brush piece to the greatest extent, and the capsule can be used to the greatest extent. The concave storage channel is adopted, and when the forefront end of the soft brush piece is required to be used, gel stored in the concave storage channel can flow out of the front end outlet rapidly, so that the application by a user is facilitated. The supporting rod part with the stop protruding part is further adopted, so that in the extrusion process, the extrusion rod is pushed first, and then the pushing of the rear push rod is automatically switched through the action of the supporting rod part. The rubber ring can be further added, when the front half part of the capsule is extruded, the rubber ring is connected to the first-stage protruding outer ring part from the rear protruding outer ring part, and when the rear half part of the capsule is extruded, the rubber ring is connected to the second-stage protruding outer ring part from the rear protruding outer ring part, so that the extrusion force born by the capsule is kept in a reasonable range, errors are reduced, and convenience in use is improved. .
The foregoing examples are provided to further illustrate the technical contents of the present invention for the convenience of the reader, but are not intended to limit the embodiments of the present invention thereto, and any technical extension or re-creation according to the present invention is protected by the present invention. The protection scope of the invention is subject to the claims.
Claims (2)
1. The application tool of the instant polyacrylic acid silver fluoride dental caries prevention paste is characterized in that the instant polyacrylic acid silver fluoride dental caries prevention paste is prepared from the following raw materials in parts by weight according to the weight of a finished product:
10-15 parts of carbomer 940;
15-20 parts of glycerol;
3-5 parts of zein;
0.1-1 part of licochalcone A;
5-10 parts of dimethyl sulfoxide (DMSO);
35-40 parts of silver fluoride (AgF);
in the preparation process, a proper amount of any solution which has no influence on the reaction is required to be used as a solvent of the whole gel system; calculating the dosage of the solvent according to the weight parts of the raw materials and the concentration requirement of the solvent; adjusting the pH to form a homogeneous gel system;
packaging the instant silver polyacrylate caries prevention paste into a single caries prevention capsule by adopting a soft film, wherein the caries prevention capsule is externally sleeved with the smearing tool, the smearing tool comprises a cylindrical body with a hollow cavity, the rear end of the cylindrical body is opened, the front end of the cylindrical body is connected with a soft brush piece, and the soft brush piece is communicated with the caries prevention capsule in the hollow cavity through a flow guider; the rear end of the cylindrical body is opened and is connected with an extrusion rod penetrating into the hollow cavity, and the caries prevention capsule arranged in the hollow cavity and an internal flow passage arranged in the soft brush piece are communicated through the flow guider; the surface of the soft brush piece is provided with a plurality of extrusion ports communicated with the inner runner; the extrusion rod comprises a hollow pipe and a concave end cover which is arranged at the front end of the hollow pipe and made of soft materials so as to adapt to the shape of the caries prevention capsule; a rear push rod extending backwards is arranged in the hollow tube; the outer side of the rear end of the extrusion rod is provided with a middle convex outer ring part, and the outer side of the rear end of the rear push rod is provided with a rear convex outer ring part; the rear convex outer ring part is provided with a plurality of support rod parts in a forward extending mode, and the inner side of the front end of each support rod part is provided with a guide inclined plane and a stop protruding part for stopping the middle convex outer ring part;
the rubber ring is connected from the rear bulge outer ring part to the position of the first-stage bulge outer ring part when the front half part of the capsule is extruded, and is connected from the rear bulge outer ring part to the position of the second-stage bulge outer ring part when the rear half part of the capsule is extruded;
the front end of the cylindrical body is provided with a front mounting hole for penetrating the soft brush piece and a threaded hole positioned at the rear end of the front mounting hole, the threaded hole is connected with the deflector, the deflector is also provided with a backward extending duct part, and the rear end of the duct part is pointed so as to break the front end of the caries preventing capsule; a narrow part is arranged on the inner flow passage of the soft brush piece, and an outer inclined surface is arranged at the outer side corresponding to the narrow part; the adjusting nut is connected with the front end of the front section in a threaded manner, and the adjusting nut moves back and forth;
the cylindrical body comprises a front section and a rear section, the front section and the rear section are in threaded connection or snap connection, and the front end of the front section is conical; the rear end of the soft brush piece is a clamping part, and the front end of the soft brush piece is in a circular arc flat shape; the extrusion port is arranged on one side or two sides of the flat shape; the front end outlet is positioned at the front end of the flat shape and is communicated with the inner flow passage through a concave storage passage; the elastic rubber ring is characterized by further comprising a hook bulge used for hanging the elastic rubber ring, wherein the rear end face of the rear push rod is provided with a transverse groove used for embedding the elastic rubber ring, two ends of the elastic rubber ring are respectively hung on the hook bulge, and the middle part of the elastic rubber ring bypasses the rear end face of the rear push rod and is embedded into the transverse groove.
2. The application tool of the instant type silver polyacrylate fluoride caries prevention paste according to claim 1, wherein the steps of synthesizing the instant type silver polyacrylate fluoride caries prevention paste are as follows:
preparing 75% -85% alcohol glycerol solution by weight concentration; sequentially adding zein, licochalcone A and carbomer 940 into the alcohol glycerol solution, and fully mixing to prepare a silver polyacrylate fluoride solution A;
in a negative pressure environment, adding dimethyl sulfoxide into deionized water, regulating the pH to 9-10 by ammonia water, and then adding silver fluoride to prepare silver fluoride solution B with the aged specific gravity of 3.9-4.1 g/mL;
and pouring the polyacrylic acid gel solution A into the silver fluoride solution B in a sealing mode, stirring and mixing to obtain the instant polyacrylic acid silver fluoride caries prevention paste.
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1291325A (en) * | 1970-09-07 | 1972-10-04 | Reiichi Yamaga | Silver ammine fluoride solution and method of its use |
| CN108434174A (en) * | 2018-04-23 | 2018-08-24 | 山东大学 | It is a kind of to be used to assist dental caries therapeutic and the mouth sprays and preparation method thereof of pre- anti-caries |
| CN110236958A (en) * | 2019-06-28 | 2019-09-17 | 武汉大学 | It is a kind of for promoting the material and preparation method thereof of tooth defect missing tissues reparation |
| CN211356029U (en) * | 2020-01-02 | 2020-08-28 | 杨琦琦 | Convenient fluorine device of scribbling for department of stomatology |
| CN211884125U (en) * | 2020-03-16 | 2020-11-10 | 国创河北医疗器械有限公司 | Decayed tooth decay-removing bacteriostatic gel device |
| CN213525625U (en) * | 2020-05-26 | 2021-06-25 | 曲靖市第一人民医院 | Department of stomatology is with scribbling fluorine device of prevention children's decayed tooth |
| CN113712828A (en) * | 2021-10-08 | 2021-11-30 | 广州蝶恋花生物科技有限公司 | Pickering emulsion with relieving effect and application thereof |
| CN114191120A (en) * | 2021-12-20 | 2022-03-18 | 山东大学 | Orthodontic tooth surface acid etching device |
| WO2022081430A1 (en) * | 2020-10-15 | 2022-04-21 | Advantage Silver Dental Arrest, Llc | A thickened silver diamine fluoride composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015200141A1 (en) * | 2014-06-27 | 2015-12-30 | NoDK, LLC | Dual applicator |
-
2022
- 2022-07-28 CN CN202210896988.9A patent/CN115350098B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1291325A (en) * | 1970-09-07 | 1972-10-04 | Reiichi Yamaga | Silver ammine fluoride solution and method of its use |
| CN108434174A (en) * | 2018-04-23 | 2018-08-24 | 山东大学 | It is a kind of to be used to assist dental caries therapeutic and the mouth sprays and preparation method thereof of pre- anti-caries |
| CN110236958A (en) * | 2019-06-28 | 2019-09-17 | 武汉大学 | It is a kind of for promoting the material and preparation method thereof of tooth defect missing tissues reparation |
| CN211356029U (en) * | 2020-01-02 | 2020-08-28 | 杨琦琦 | Convenient fluorine device of scribbling for department of stomatology |
| CN211884125U (en) * | 2020-03-16 | 2020-11-10 | 国创河北医疗器械有限公司 | Decayed tooth decay-removing bacteriostatic gel device |
| CN213525625U (en) * | 2020-05-26 | 2021-06-25 | 曲靖市第一人民医院 | Department of stomatology is with scribbling fluorine device of prevention children's decayed tooth |
| WO2022081430A1 (en) * | 2020-10-15 | 2022-04-21 | Advantage Silver Dental Arrest, Llc | A thickened silver diamine fluoride composition |
| CN113712828A (en) * | 2021-10-08 | 2021-11-30 | 广州蝶恋花生物科技有限公司 | Pickering emulsion with relieving effect and application thereof |
| CN114191120A (en) * | 2021-12-20 | 2022-03-18 | 山东大学 | Orthodontic tooth surface acid etching device |
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| CN115350098A (en) | 2022-11-18 |
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