CN115308176A - Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells - Google Patents

Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells Download PDF

Info

Publication number
CN115308176A
CN115308176A CN202210886685.9A CN202210886685A CN115308176A CN 115308176 A CN115308176 A CN 115308176A CN 202210886685 A CN202210886685 A CN 202210886685A CN 115308176 A CN115308176 A CN 115308176A
Authority
CN
China
Prior art keywords
fluorescence imaging
imaging device
device body
heat
imaging system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210886685.9A
Other languages
Chinese (zh)
Inventor
葛少华
李玮
邵金龙
王文霞
李景媛
陈荟
王彩娇
田崇轩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong University
Original Assignee
Shandong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shandong University filed Critical Shandong University
Priority to CN202210886685.9A priority Critical patent/CN115308176A/en
Publication of CN115308176A publication Critical patent/CN115308176A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K7/00Constructional details common to different types of electric apparatus
    • H05K7/20Modifications to facilitate cooling, ventilating, or heating
    • H05K7/2029Modifications to facilitate cooling, ventilating, or heating using a liquid coolant with phase change in electronic enclosures
    • H05K7/20327Accessories for moving fluid, for connecting fluid conduits, for distributing fluid or for preventing leakage, e.g. pumps, tanks or manifolds
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K7/00Constructional details common to different types of electric apparatus
    • H05K7/20Modifications to facilitate cooling, ventilating, or heating
    • H05K7/2029Modifications to facilitate cooling, ventilating, or heating using a liquid coolant with phase change in electronic enclosures
    • H05K7/20345Sprayers; Atomizers
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K7/00Constructional details common to different types of electric apparatus
    • H05K7/20Modifications to facilitate cooling, ventilating, or heating
    • H05K7/2039Modifications to facilitate cooling, ventilating, or heating characterised by the heat transfer by conduction from the heat generating element to a dissipating body
    • H05K7/20409Outer radiating structures on heat dissipating housings, e.g. fins integrated with the housing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106General arrangement of respective parts
    • G01N2021/0112Apparatus in one mechanical, optical or electronic block

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention provides an oral mucosa multi-frequency fluorescence imaging system and method for judging cancerous cells, which comprises a fluorescence imaging device body, a display unit and a heat dissipation unit, wherein the fluorescence imaging device body is connected with the display unit, and the display unit is used for displaying an image of the fluorescence imaging device body; the fluorescence imaging body is also connected with a heat dissipation unit, and the heat dissipation unit is used for dissipating heat of the fluorescence imaging body; the heat that can produce its fluorescence imaging device body work absorbs, can increase and the outside air between area of contact, conveniently accelerate the radiating rate of fluorescence imaging device body from this, make things convenient for the better outside of heat that fluorescence imaging device body during operation produced to give off.

Description

Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells
Technical Field
The invention belongs to the technical field of fluorescence imaging devices, and particularly relates to an oral mucosa multi-frequency fluorescence imaging system and method for judging cancerous cells.
Background
The statements in this section merely provide background information related to the present disclosure and may not necessarily constitute prior art.
Fluorescence is a common luminescence phenomenon in the nature, wherein fluorescence is generated by utilizing the interaction of photons and molecules, fluorescence imaging is that the intensity of a fluorescence signal emitted by a fluorescent material after being excited has a linear relation with the amount of fluorescein in a certain range, corresponding fluorescence diagnosis is usually used during detection of oral mucosa diseases, a fluorescent lamp irradiates oral mucosa tissues, and then a fluorescence imaging device is adopted to pick up and display the tissues.
The mucosa is a layer of film covering the inner wall of the lumen of organs such as digestion, respiration, urinary and the like in human and animal bodies, wherein the mucosa comprises oral mucosa, when the shape of the oral mucosa is observed, a fluorescence labeling method is used for labeling cells to be observed, the fluorescence labeling has the characteristics of no selectivity to a template, convenient use and the like, and is widely applied and cell-labeled, and the oral mucosa tissue after being fluorescently labeled needs to be observed by using an imaging device.
However, the existing fluorescence imaging device has the following problems:
at present, the conventional imaging device has certain defects in the detection of multiple groups of samples, and the common detection method is that a tissue sample glass slide after fluorescence treatment is placed at the bottom of the imaging device to observe a single tissue sample, when the tissue samples needing to be observed are more, a large amount of time is needed for observation, so that the problem of low efficiency occurs, and when a plurality of tissue samples are observed, frequent repeated observation operation is needed, so that the fatigue condition of workers is easy to occur.
A medical image imaging device as publication No. CN213366153U, which includes a housing, a base is disposed at a lower end of the housing, a plurality of shock absorbing devices are disposed at a lower end of the base, a drawer is disposed inside the housing, and a keyboard is disposed at an upper end of the drawer, so that a cold water source of the medical image imaging device circulates under the action of a cooling fan and a circulating pump during use, thereby achieving cooling of the imaging device.
Disclosure of Invention
The invention aims to solve the problems and provides an oral mucosa multi-frequency fluorescence imaging system and method for judging cancerous cells, which can improve the self heat dissipation effect in the use process, conveniently reduce the heat of the surrounding air in the heat dissipation process, and facilitate the heat generated by work to be better dissipated outwards.
According to some embodiments, the invention adopts the following technical scheme:
in a first aspect, the present invention provides an oral mucosa multi-frequency fluorescence imaging system for identifying cancerous cells, comprising a fluorescence imaging device body, a display unit and a heat dissipation unit, wherein the fluorescence imaging device body is connected with the display unit, and the display unit is used for displaying an image of the fluorescence imaging device body; the fluorescence imaging body is further connected with the heat dissipation unit, and the heat dissipation unit is used for dissipating heat of the fluorescence imaging body.
Furthermore, the heat dissipation unit includes heat-conducting plate and protection casing, the heat-conducting plate runs through to be installed on the protection casing, and protection casing fixed connection is in the back of fluorescence imaging device body.
Furthermore, a branch block is installed at the end part of the heat conducting plate, and the surface of the branch block is inwards sunken to form a groove.
Furthermore, the heat dissipation unit further comprises a water tank heat dissipation mechanism, and the water tank heat dissipation mechanism comprises a water tank, a water pump, a water suction pipe, a drainage pipe, a spray head, a positioning rack, a movable toothed block, a transmission impeller, a fixed rod, a backflow pipe and a baffle plate.
Furthermore, the water tank sets up the avris about fluorescence imaging device main part, the water pump to the water source transmission is installed to the upper end of water tank, and through the pipe interconnect that absorbs water between water pump and the water tank.
Furthermore, one end of the drainage tube is connected to the side of the water pump, the other end of the drainage tube is installed on the spray head, the spray head is fixedly connected with the positioning rack, and the positioning rack is connected with the protective cover through a spring.
Furthermore, the movable tooth block is arranged at the lower end of the positioning rack, the movable tooth block is arranged on the central rod, and the middle part of the central rod is provided with a transmission impeller; the upper end of the fixing rod is installed on the center rod, a pushing plate is fixedly connected to the left side of the lower end of the fixing rod, the left end of the pushing plate extends into the metal pipe, and a protruding strip is installed on the outer side of the metal pipe.
Furthermore, one end of a return pipe is arranged at the lower end of the metal pipe, and the other end of the return pipe is arranged on the side of the water tank; the baffle is installed the inside of tubular metal resonator, through stay cord interconnect between baffle and the beating board, and the rotation axis outside of baffle and beating board all is provided with the torsion spring who provides reset elasticity.
Further, fluorescence imaging device body is for utilizing the oral mucosa imaging device of fluorescence imaging method, including unable adjustment base, connection frame and support frame, unable adjustment base's top fixedly connected with connection frame, and connection frame's top welded connection has the support frame to the inside nestification in left side of support frame has the connecting block, and the tip fixedly connected with fluorescence microscope of connecting block simultaneously.
Furthermore, the fluorescence imaging device body still includes rotating gear, drive gear, first roller, first runner and conveyer belt.
Furthermore, the rotating gear is movably arranged inside the connecting frame, the side of the rotating gear is meshed with the transmission gear, the end part of one side of the transmission gear is fixedly connected with the first rolling roller, and the other end of the first rolling roller is fixedly connected with the first rotating wheel.
Furthermore, the outer side of the first roller is attached to a conveying belt, a connecting groove is formed in the conveying belt, and a slide placing box is mounted inside the connecting groove.
Furthermore, the fluorescence imaging device body further comprises a fixing frame, the fixing frame is installed on the right side of the supporting frame, a second rotating wheel is movably installed on the outer side of the fixing frame, and a conveying belt is connected to the outer side of the second rotating wheel.
In a second aspect, the present invention provides a working method of the multi-frequency fluorescence imaging system for identifying cancer cells in the oral mucosa according to the first aspect, including:
detecting the oral mucosa through the fluorescence imaging device body;
displaying the image of the fluorescence imaging body through a display unit;
the fluorescence imaging body is cooled through the cooling unit.
Compared with the prior art, the invention has the beneficial effects that:
1. this application is provided with the heat-conducting plate, thereby can absorb the heat that its fluorescence imaging device body work produced through the setting at the fluorescence imaging device body back of heat-conducting plate, utilize the recess of inside sunken formation on the branch piece and the branch piece of heat-conducting plate tip simultaneously to can increase and the outside air between the area of contact, conveniently accelerate the radiating rate of fluorescence imaging device body from this.
2. This application is provided with the location rack, can make further cooling to the heat-conducting plate through the outside spun water source of shower nozzle, when spun water source flowed into to the transmission impeller on, the rotation of transmission impeller can utilize well core rod to drive movable tooth piece and rotate in step, on tooth piece and location rack on the movable tooth piece break away from between the tooth piece and contact can make its location rack drive shower nozzle about reciprocating motion, reciprocating motion can improve the scope of spraying to the water source about utilizing the shower nozzle from this.
3. This application is provided with the propulsion board, can make threaded connection's dead lever control reciprocating motion when well core rod rotates, utilize the dead lever about reciprocating motion and then can drive the propulsion board and carry out reciprocating motion in the inside of tubular metal resonator, steam through the reciprocating motion of propulsion board can be around inhales to the inside of tubular metal resonator, absorb the heat of air through the tubular metal resonator, from this reduce the heat of air on every side, make things convenient for the better outside of heat that fluorescence imaging device body during operation produced to give off.
4. This application is provided with hits the beater plate, when advancing the board and carrying out reciprocating motion in the inside of tubular metal resonator, the baffle can carry out reciprocating rotation under torque spring's effect, can utilize the stay cord to make it hit the pole and carry out synchronous rotation through the reciprocating rotation of baffle, thereby can break up shower nozzle spun water source through hitting the pole and rotating at the shower nozzle lower extreme, improves the scope at shower nozzle spun water source from this.
5. The oral mucosa imaging device utilizing the fluorescence imaging method is provided with the fluorescence microscope and the rotating lead screw, the driving gear is connected with the connecting gear through the chain by controlling the rotation of the driving gear, the connecting gear is provided with two groups, the diameter of the connecting gear is the same as that of the driving gear, the rotating lead screw is fixedly connected to the bottoms of the connecting gear and the driving gear, and then the multiple groups of rotating lead screws are driven to rotate simultaneously;
6. the oral mucosa imaging device utilizing the fluorescence imaging method is provided with the glass slide placing boxes and the connecting grooves, the glass slide placing boxes are nested in the connecting grooves, the fixing of the glass slide placing boxes is realized by utilizing the connecting grooves which are formed in the conveying belt at equal intervals, the glass slide placing boxes are driven to carry out fixed-distance conveying by utilizing the movement of the conveying belt, and samples in the multiple groups of glass slide placing boxes can be observed conveniently by utilizing a fluorescence microscope;
7. this application utilizes oral cavity mucous membrane image device of fluorescence imaging method to be provided with and presses and covers roller and buffer spacer, the second runner that utilizes the mount outside rotates, the second runner links to each other with the pressure roller that covers, drive and press and cover the roller and rotate with the buffer spacer that presses and cover the roller outside, and buffer spacer's bottommost height is the same with the topmost height that the box was placed to the slide glass, the rotation that utilizes buffer spacer comes to place the box to the slide glass and presses and covers, let the slide glass place the bottom in close contact with of box and coupling groove, it is in the same height to let the slide glass place the box, it is different effectively to avoid the slide glass to place the height of box, and produce the condition of influence to follow-up fluorescence microscope's observation.
Advantages of additional aspects of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are included to illustrate an exemplary embodiment of the invention and not to limit the invention.
FIG. 1 is a schematic front view of a multi-frequency fluorescence imaging system according to the present invention;
FIG. 2 is a schematic view of the backside structure of the shield of the present invention;
FIG. 3 is a perspective view of the heat-conducting plate and the branch block of the present invention;
FIG. 4 is a schematic cross-sectional view of the shield and striking plate of the present invention;
FIG. 5 is a schematic cross-sectional view of a pusher plate and metal tube according to the present invention;
FIG. 6 is a side view of the positioning rack and the movable tooth block of the present invention;
FIG. 7 is a schematic view of a top-down structure of a metal tube and a baffle according to the present invention;
fig. 8 is a schematic sectional view of the torsion spring according to the present invention.
FIG. 9 is a schematic front view of a fluorescence imaging device according to the present invention;
FIG. 10 is a side view of the interior of the stand of the present invention;
FIG. 11 is a schematic top view of the connecting gear and the driving gear of the present invention;
FIG. 12 is a schematic view of the connection structure between the connection frame and the inside of the first roller according to the present invention;
FIG. 13 is a top view of the internal structure of the connecting frame of the present invention;
FIG. 14 is a side view of the connecting structure of the transmission gear and the rotation gear of the present invention;
wherein: 1. a fluorescence imaging device body; 2. a display screen; 3. a heat conducting plate; 4. a protective cover; 5. a branching block; 6. a groove; 7. a water tank; 8. a water pump; 9. a suction pipe; 10. a drainage tube; 11. a spray head; 12. positioning the rack; 13. a movable tooth block; 14. a center pole; 15. a drive impeller; 16. fixing the rod; 17. a pusher plate; 18. a metal tube; 19. a convex strip; 20. a return pipe; 21. a baffle plate; 22. pulling a rope; 23. striking a board; 101. A fixed base; 102. a connecting frame; 103. a support frame; 104. a lifting block; 105. connecting blocks; 106. A fluorescence microscope; 107. rotating the screw rod; 108. a connecting gear; 109. a chain; 110. a drive gear; 111. a rotating gear; 112. a transmission gear; 113. a first roll; 114. a first runner; 115. a conveyor belt; 116. a connecting groove; 117. a slide glass placing box; 118. a second roll; 119. a connecting belt; 120. A second runner; 121. a fixing frame.
The specific implementation mode is as follows:
the invention is further described with reference to the following figures and examples.
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
The first embodiment is as follows:
the embodiment provides an oral mucosa multi-frequency fluorescence imaging system and method for judging cancerous cells, and the system comprises a fluorescence imaging device body, a display unit and a heat dissipation unit, wherein the fluorescence imaging device body is connected with the display unit, and the display unit is used for displaying an image of the fluorescence imaging device body; the fluorescence imaging body is also connected with a heat dissipation unit, and the heat dissipation unit is used for dissipating heat of the fluorescence imaging body;
the display unit comprises a display screen, and the fluorescence imaging device body is connected with the display screen.
The heat dissipation unit comprises a heat conduction plate, a protective cover and a water tank heat dissipation mechanism, the heat conduction plate is installed on the protective cover in a penetrating mode, the protective cover is fixedly connected to the back face of the fluorescence imaging device body, a branch block is installed at the end portion of the heat conduction plate, and the surface of the branch block is sunken inwards to form a groove. Preferably, the branch blocks are uniformly distributed at the end part of the heat-conducting plate, and a plurality of inwards-concave grooves are formed in the uniformly-distributed branch blocks.
The water tank heat dissipation mechanism comprises a water tank, a water pump, a water suction pipe, a drainage pipe, a spray head, a positioning rack, a movable toothed block, a transmission impeller, a fixed rod, a return pipe and a baffle plate, the water tank is arranged on the left side and the right side of the fluorescence imaging device main body, the water pump for transmitting water source is arranged at the upper end of the water tank, and the water pump and the water tank are connected with each other through the water suction pipe;
one end of the drainage tube is connected to the side of the water pump, the other end of the drainage tube is installed on the spray head, the spray head is fixedly connected with the positioning rack, and the positioning rack is connected with the protective cover through a spring; the movable tooth block is arranged at the lower end of the positioning rack, the movable tooth block is arranged on the central rod, and the middle part of the central rod is provided with a transmission impeller; the upper end of the fixed rod is mounted on the central rod, the left side of the lower end of the fixed rod is fixedly connected with a pushing plate, the left end of the pushing plate extends into the metal pipe, and a raised line is mounted on the outer side of the metal pipe; one end of the return pipe is arranged at the lower end of the metal pipe, and the other end of the return pipe is arranged at the side of the water tank; the baffle is installed the inside of tubular metal resonator, through stay cord interconnect between baffle and the beating board, and the rotation axis outside of baffle and beating board all is provided with the torsion spring who provides reset elasticity.
Through adopting above-mentioned technical scheme, utilize setting up of spring can make the location rack after the removal rebound and reset, thereby utilize the removal of location rack to drive the shower nozzle and carry out synchronous motion simultaneously.
Preferably, the tooth blocks on the surfaces of the lower end tooth block and the movable tooth block of the positioning rack are in meshed connection, the movable tooth block is of a fan-shaped structure, and the movable tooth block and the central rod are in key connection.
Through adopting above-mentioned technical scheme, when the tooth piece on the movable tooth piece and the tooth piece of location rack lower extreme intermeshing to can make the location rack remove, when the tooth piece on the movable tooth piece does not intermesh with the tooth piece on the location rack, the movable tooth piece can reset under the effect of spring.
Preferably, the right end surface of the central rod is provided with reciprocating threads, the central rod is in threaded connection with the fixed rod, and the fixed rod and the pushing plate are vertically distributed.
Through adopting above-mentioned technical scheme, the rotation that utilizes well core rod can make threaded connection's dead lever carry out reciprocating motion under the reciprocal screw thread effect that sets up on its surface, and then can drive the propulsion board through the reciprocating motion of dead lever and carry out synchronous motion.
Preferably, the diameter of the left end of the propulsion plate is equal to the inner diameter of the metal pipe, and convex strips are uniformly distributed on the outer surface of the metal pipe.
Through adopting above-mentioned technical scheme, the diameter of propulsion board equals with the internal diameter of tubular metal resonator to can improve the stability of propulsion board at the inside removal of tubular metal resonator, avoid the propulsion board to appear rocking phenomenon in the inside of tubular metal resonator.
Preferably, be the integrated into one piece structure between the surface of sand grip and tubular metal resonator, and the sand grip sets up to annular structure.
Through adopting above-mentioned technical scheme, thereby can improve and improve the cooling effect of tubular metal resonator with the area of contact between the water source through the sand grip at the evenly distributed sand grip on tubular metal resonator surface.
Preferably, a rotating structure is formed between the baffle plate and the inner wall of the metal pipe, and the right side of the baffle plate is attached to a protrusion formed on the inner wall of the metal pipe, so as to limit the rotating direction of the baffle plate.
Through adopting above-mentioned technical scheme, thereby can avoid the baffle to carry out anticlockwise rotation in the inside of tubular metal resonator through bellied setting, can utilize the stay cord pulling to hit the beater to carry out synchronous revolution simultaneously through the rotation of baffle.
Preferably, the beating plate and the spray head are positioned on the same vertical straight line, and a rotating structure is formed between the beating plate and the protective cover.
Through adopting above-mentioned technical scheme, thereby can break up shower nozzle spun water source through hitting the rotation of beating the board in the shower nozzle bottom, improve the area that sprays at water source from this, increase the radiating effect to the heat-conducting plate.
Referring to fig. 1-8, the present invention provides a technical solution: an oral mucosa multi-frequency fluorescence imaging system for distinguishing cancerous cells comprises a fluorescence imaging device body 1 and a display screen 2, wherein the fluorescence imaging device body 1 is provided with the display screen 2 for displaying images; further comprising: the heat conducting plate 3 is arranged on the back surface of the fluorescence imaging device body 1, the heat conducting plate 3 is arranged on the protective cover 4 in a penetrating mode, the protective cover 4 is fixedly connected to the back surface of the fluorescence imaging device body 1, the end portion of the heat conducting plate 3 is provided with the branch block 5, and the surface of the branch block 5 is inwards sunken to form a groove 6;
as shown in fig. 1 to 3, when the fluorescence imaging device body 1 has a high heat value during the operation, the heat on the fluorescence imaging device body 1 is absorbed by the heat conducting plate 3 on the back surface thereof, and the heat absorbed by the heat conducting plate 3 is transferred to the branch block 5, so that the heat on the branch block 5 and the heat conducting plate 3 can be dissipated by the air flowing from the outside, and the contact area with the outside air can be increased by the grooves 6 uniformly distributed on the branch block 5, thereby increasing the whole heat dissipation effect.
The water tank 7 is arranged on the left side and the right side of the fluorescence imaging device main body 1, a water pump 8 for water source transmission is arranged at the upper end of the water tank 7, and the water pump 8 and the water tank 7 are mutually connected through a water suction pipe 9; one end of the drainage tube 10 is connected to the side of the water pump 8, the other end of the drainage tube 10 is installed on the spray head 11, the spray head 11 is fixedly connected with the positioning rack 12, and the positioning rack 12 is connected with the protective cover 4 through a spring;
the movable tooth block 13 is arranged at the lower end of the positioning rack 12, the movable tooth block 13 is installed on the central rod 14, and the middle part of the central rod 14 is provided with a transmission impeller 15; the upper end of the fixed rod 16 is installed on the central rod 14, the left side of the lower end of the fixed rod 16 is fixedly connected with a pushing plate 17, the left end of the pushing plate 17 extends into the metal pipe 18, and a raised line 19 is installed on the outer side of the metal pipe 18; a return pipe 20, one end of which is arranged at the lower end of the metal pipe 18, and the other end of the return pipe 20 is arranged at the side of the water tank 7;
the branch blocks 5 are uniformly distributed at the end part of the heat-conducting plate 3, and a plurality of inwards concave grooves 6 are arranged on the branch blocks 5 which are uniformly distributed. The positioning rack 12 forms an elastic telescopic structure with the protective cover 4 through a spring, and the positioning rack 12 and the spray head 11 are of a welding integrated structure. The lower end tooth block of the positioning rack 12 is in meshed connection with the tooth block on the surface of the movable tooth block 13, the movable tooth block 13 is in a fan-shaped structure, and the movable tooth block 13 is in key connection with the central rod 14. The right end surface of the central rod 14 is provided with reciprocating threads, the central rod 14 is in threaded connection with the fixed rod 16, and the fixed rod 16 and the pushing plate 17 are vertically distributed. The diameter of the left end of the pushing plate 17 is equal to the inner diameter of the metal tube 18, and convex strips 19 are uniformly distributed on the outer surface of the metal tube 18. The raised strips 19 and the outer surface of the metal tube 18 are integrally formed, and the raised strips 19 are arranged into an annular structure.
As shown in fig. 1-6, the water pump 8 is turned on, the water source in the water tank 7 can be delivered to the spray head 11 by the water suction pipe 9 and the drainage pipe 10 when the water pump 8 is turned on, the cold water source is sprayed onto the heat conducting plate 3 through the spray head 11, so that the heat on the heat conducting plate 3 is dissipated more rapidly, the water source is gathered after being sprayed onto the heat conducting plate 3, the water source impacts the driving impeller 15, the driving impeller 15 is impacted by the water flow to drive the movable toothed block 13 to rotate synchronously under the action of the central rod 14, when the toothed block on the movable toothed block 13 is meshed with the toothed block on the positioning rack 12, the positioning rack 12 can drive the spray head 11 to rotate synchronously, when the toothed block on the movable toothed block 13 is separated from the toothed block on the positioning rack 12, the positioning rack 12 resets the spray head 11 under the action of the spring, thereby realizing the reciprocating movement of the spray head 11, the spraying range of the water source can be further improved through the reciprocating movement of the spray head 11, the water source can be uniformly sprayed on the surface of the heat guide plate 3, meanwhile, when the central rod 14 rotates along with the transmission impeller 15, the rotation of the central rod 14 can enable the fixing rod 16 to reciprocate left and right under the action of reciprocating threads on the central rod, the pushing plate 17 can move synchronously through the reciprocating movement of the fixing rod 16 left and right, the outside hot air can be sucked into the metal pipe 18 and then discharged outwards through the reciprocating movement of the pushing plate 17 in the metal pipe 18, after the hot air enters the metal pipe 18, the heat in the air can be absorbed through the metal pipe 18, so that the heat of the air around the fluorescence imaging device body 1 is reduced, after the transmission impeller 15 is impacted by water flow, the water source flows to the outer surface of the metal pipe 18, the metal pipe 18 can be cooled by a water source.
The baffle 21 is arranged inside the metal tube 18, the baffle 21 and the striking plate 23 are connected with each other through a pull rope 22, and torsion springs 24 for providing return elasticity are arranged outside the rotating shafts of the baffle 21 and the striking plate 23. A rotating structure is formed between the baffle 21 and the inner wall of the metal tube 18, and the right side of the baffle 21 is attached to a bulge formed on the inner wall of the metal tube 18, so that the rotating direction of the baffle 21 is limited. The beating plate 23 and the spray head 11 are positioned on the same vertical straight line, and a rotating structure is formed between the beating plate 23 and the protective cover 4.
As shown in fig. 2, 4, 7 and 8, when the pushing plate 17 moves to the right side of the metal tube 18, external air can be sucked into the metal tube 18, after the pushing plate 17 moves to the left side of the metal tube 18, the air sucked into the metal tube 18 is discharged outwards, at this time, the baffle 21 rotates under the push of the air flow, so that the reciprocating rotation of the baffle 21 is realized, after the reciprocating rotation of the baffle 21, the striking plate 23 can rotate back and forth at the bottom of the nozzle 11 by the matching of the pull rope 22 and the torsion spring 24, and the water source sprayed by the nozzle 11 can be broken up by the rotation of the striking plate 23, so that the spraying range of the water source is further improved.
The working principle is as follows: when the oral mucosa multi-frequency fluorescence imaging device for identifying the cancer cells is used, firstly, as shown in fig. 1-8, the heat conducting plate 3 can absorb the heat of the fluorescence imaging device body 1 in the working process, and the heat can be quickly dissipated by utilizing the contact between the branch blocks 5 and the grooves 6 and the outside air, after the transmission impeller 15 is impacted by water flow, the positioning rack 12 can drive the spray head 11 to reciprocate under the action of the central rod 14 and the movable tooth block 13, so that the spraying range of the water source is improved, the pushing plate 17 can suck the outside hot air into the metal pipe 18 and then discharge the outside air, the heat in the air can be absorbed through the metal pipe 18, so that the heat of the air around the fluorescence imaging device body 1 is reduced, the baffle plate 21 can rotate in a reciprocating manner under the pushing of air flow, the baffle plate 21 can make the beating plate 23 rotate in a reciprocating manner under the action of the pull rope 22 and the torsion spring 24, and the water source sprayed out of the spray head 11 can be dissipated by the rotation of the beating plate 23 in a reciprocating manner, so that the spraying range of the water source is further expanded.
As an implementation mode, the fluorescence imaging device body is an oral mucosa imaging device using a fluorescence imaging method, and comprises a fixed base, a connecting frame and a support frame, wherein the top of the fixed base is fixedly connected with the connecting frame, the top of the connecting frame is connected with the support frame in a welding manner, a connecting block is nested in the left side of the support frame, and the end part of the connecting block is fixedly connected with a fluorescence microscope;
the fluoroscopic imaging apparatus body further includes:
the rotating gear is movably arranged inside the connecting frame, the side of the rotating gear is meshed with the transmission gear, the end part of one side of the transmission gear is fixedly connected with a first rolling roller, the other end of the first rolling roller is fixedly connected with a first rotating wheel, the outer side of the first rolling roller is attached and connected with a conveying belt, a connecting groove is formed in the conveying belt, and a slide placing box is arranged inside the connecting groove;
the fixing frame is fixedly installed on the right side of the supporting frame, a second rotating wheel is movably installed on the outer side of the fixing frame, and a conveying belt is connected to the outer side of the second rotating wheel.
Preferably, the lifting block and the rotating screw rod are arranged in the supporting frame;
the lifting block is fixedly connected to the end part of the connecting block;
rotate the lead screw, threaded connection in the inside of elevator, and the top fixedly connected with connecting gear who rotates the lead screw to the outside of connecting gear is connected with the chain, and drive gear is installed to the avris of connecting gear simultaneously.
Preferably, fluorescence microscope passes through connecting block, elevator and rotates the lead screw and constitutes elevation structure with the support frame, and fluorescence microscope is the equidistance setting about the support frame, utilizes the rotation that rotates the lead screw, rotates lead screw and elevator for threaded connection, drives elevator and connecting block and moves on the support frame, and connecting block and fluorescence microscope link to each other, and then drives fluorescence microscope and move, realize automatically adjusting observation height.
Preferably, the connecting gear is connected with the driving gear through the chain, and the connecting gear is provided with two about the perpendicular axis symmetry of driving gear, and the diameter of connecting gear and the diameter of driving gear equal, through the rotation of control driving gear, driving gear passes through the chain and links to each other with the connecting gear, and the connecting gear is provided with two sets ofly, and the diameter of connecting gear is the same with the diameter of driving gear, the equal fixedly connected with in bottom of connecting gear and driving gear rotates the lead screw, and then realizes driving multiunit and rotates the pivoted purpose simultaneously of lead screw.
Preferably, the diameter of the rotating gear is larger than that of the transmission gear, the rotating gear is arranged in a semi-sawtooth structure, the rotating gear drives the transmission gear on the side and the first rolling roller to rotate on the connecting frame by utilizing the rotation of the rotating gear, the diameter of the rotating gear is larger than that of the transmission gear, and the rotating gear is in the semi-sawtooth structure, so that the purpose of intermittent rotation of the transmission gear and the first rolling roller is achieved.
Preferably, the first roller and the connecting frame form a rotating structure through a transmission gear and a rotating gear, the transmission gear is in welded connection with the first roller, the first roller and the second roller are connected through a conveying belt, the rotating gear and the transmission gear in the connecting frame are used for rotating to drive the first roller to move, and the first roller is connected with the second roller through the conveying belt to further drive the conveying belt and the second roller to move.
Preferably, the glass slide placing boxes are nested in the connecting grooves, the connecting grooves are equidistantly arranged relative to the outer wall of the conveying belt, the glass slide placing boxes are nested in the connecting grooves, the connecting grooves are formed in the conveying belt at equal intervals, the glass slide placing boxes are fixed, the conveying belt moves to drive the glass slide placing boxes to carry out fixed-distance conveying, and the fluorescence microscope is convenient to use to observe the multiple glass slide placing boxes.
Preferably, the inner side of the fixing frame is movably provided with a pressing roller, the outer side of the pressing roller is connected with a buffer gasket, and the pressing roller is fixedly connected with the second rotating wheel.
Preferably, the pressing roller and the fixing frame form a rotating structure through a second rotating wheel, the pressing roller and the buffer gasket are in bonding connection, the bottommost height of the buffer gasket is the same as the topmost height of the glass slide placing box, the second rotating wheel on the outer side of the fixing frame is utilized to rotate, the second rotating wheel is connected with the pressing roller, the pressing roller and the buffer gasket on the outer side of the pressing roller are driven to rotate, the bottommost height of the buffer gasket is the same as the topmost height of the glass slide placing box, the glass slide placing box is pressed through the rotation of the buffer gasket, the glass slide placing box is in close contact with the bottom of the connecting groove, the glass slide placing box is at the same height, the situation that the heights of the glass slide placing box are different and the observation of a subsequent fluorescence microscope is affected is effectively avoided.
Specifically, the oral mucosa imaging device using the fluorescence imaging method comprises a fixed base 101, a connecting frame 102 and a support frame 103, wherein the top of the fixed base 101 is fixedly connected with the connecting frame 102, the top of the connecting frame 102 is connected with the support frame 103 in a welding manner, a connecting block 105 is nested in the left side of the support frame 103, and the end part of the connecting block 105 is fixedly connected with a fluorescence microscope 106; a lifting block 104 and a rotating screw 107 are arranged in the support frame 103; the lifting block 104 is fixedly connected to the end part of the connecting block 105; a rotating screw rod 107 which is in threaded connection with the inside of the lifting block 104, the top of the rotating screw rod 107 is fixedly connected with a connecting gear 108, the outer side of the connecting gear 108 is connected with a chain 109, and the side of the connecting gear 108 is provided with a driving gear 110; the fluorescent microscope 106 forms a lifting structure with the support frame 103 through the connecting block 105, the lifting block 104 and the rotating screw rod 107, the fluorescent microscope 106 is arranged at equal intervals relative to the support frame 103, the connecting gear 108 is connected with the driving gear 110 through the chain 109, two connecting gears 108 are symmetrically arranged relative to the vertical middle axis of the driving gear 110, the diameter of the connecting gear 108 is equal to that of the driving gear 110, the driving gear 110 is connected with the connecting gear 108 through the chain 109 by controlling the rotation of the driving gear 110, two groups of connecting gears 108 are arranged, the diameter of the connecting gear 108 is equal to that of the driving gear 110, the rotating screw rods 107 are fixedly connected to the bottoms of the connecting gear 108 and the driving gear 110, the multiple groups of rotating screw rods 107 are driven to rotate simultaneously, the rotating screw rods 107 and the lifting block 104 are in threaded connection to drive the lifting block 104 and the connecting block 105 to move on the support frame 103, the connecting block 105 is connected with the fluorescent microscope 106 to drive the fluorescent microscope 106 to move, so as to realize automatic adjustment of the observation heights, and the multiple groups of the fluorescent microscope 106 and the observation efficiency can be observed;
the driving gear 110 is movably arranged inside the connecting frame 102, the side of the driving gear 110 is engaged and connected with a transmission gear 112, the end part of one side of the transmission gear 112 is fixedly connected with a first rolling roller 113, meanwhile, the other end of the first rolling roller 113 is fixedly connected with a first rotating wheel 114, the diameter of the driving gear 110 is larger than that of the transmission gear 112, and the driving gear 110 is arranged in a semi-sawtooth structure; the first roller 113 and the connecting frame 102 form a rotating structure through a transmission gear 112 and a driving gear 110, the transmission gear 112 and the first roller 113 are connected in a welding mode, the first roller 113 and the second roller 118 are connected through a conveying belt 115, the transmission gear 112 and the first roller 113 on the side are driven by the driving gear 110 to rotate on the connecting frame 102 through the rotation of the driving gear 110, the diameter of the driving gear 110 is larger than that of the transmission gear 112, the driving gear 110 is in a semi-sawtooth structure, the purpose of intermittent rotation of the transmission gear 112 and the first roller 113 is achieved, the first roller 113 and the second roller 118 are connected through the conveying belt 115, the first roller 113 and the second roller 112 in the connecting frame 102 are driven to move through the rotation of the driving gear 110 and the transmission gear 112, the first roller 113 is connected through the conveying belt 115 and the second roller 118, and the conveying belt 115 and the second roller 118 are driven to move, and the purpose of automatic movement of a slide glass slide placing box 117 on the conveying belt 115 is driven;
the outer side of the first roller 113 is attached with a conveying belt 115, a connecting groove 116 is formed in the conveying belt 115, a slide placing box 117 is mounted in the connecting groove 116, the slide placing box 117 is nested in the connecting groove 116, the connecting groove 116 is equidistantly arranged with respect to the outer wall of the conveying belt 115, the slide placing box 117 is nested in the connecting groove 116, the plurality of slide placing boxes 117 are fixed by the aid of the plurality of connecting grooves 116 equidistantly formed in the conveying belt 115, the slide placing boxes 117 are driven to be conveyed at a fixed distance by the aid of movement of the conveying belt 115, and samples in the plurality of groups of slide placing boxes 117 can be observed by the aid of the fluorescence microscope 106;
the fixing frame 121 is fixedly installed on the right side of the supporting frame 103, a second rotating wheel 120 is movably installed on the outer side of the fixing frame 121, the conveying belt 115 is connected to the outer side of the second rotating wheel 120, a pressing roller is movably installed on the inner side of the fixing frame 121, a buffer gasket is connected to the outer side of the pressing roller, and the pressing roller and the second rotating wheel 120 are fixedly connected; the pressing roller and the buffer pad are connected in a bonding mode, the bottommost height of the buffer pad is the same as the topmost height of the slide glass placing box 117, the second roller 120 on the outer side of the fixing frame 121 is used for rotating, the second roller 120 is connected with the pressing roller to drive the pressing roller and the buffer pad on the outer side of the pressing roller to rotate, the bottommost height of the buffer pad is the same as the topmost height of the slide glass placing box 117, the slide glass placing box 117 is pressed by the rotation of the buffer pad, the slide glass placing box 117 is in close contact with the bottom of the connecting groove 116, the slide glass placing box 117 is at the same height, the situation that the slide glass placing box 117 is different in height and influences the observation of the subsequent fluorescence microscope 106 is effectively avoided.
The working principle is as follows: when the oral mucosa imaging device using the fluorescence imaging method is used, according to fig. 1-8, the collected oral mucosa is placed on a slide glass, the oral mucosa placed on the slide glass is marked by using a fluorescence staining reagent, the slide glass with the fluorescence staining mark is placed inside a slide glass placing box 117, a connecting frame 102 is fixed on a fixed base 101, then a driving motor located at the side of the connecting frame 102 is started, the output end of the driving motor is connected with a driving gear 110, the driving gear 110 drives a transmission gear 112 and a first roller 113 at the side to rotate on the connecting frame 102 by using the rotation of the driving gear 110, the diameter of the driving gear 110 is larger than that of the transmission gear 112, and the driving gear 110 is in a semi-saw-toothed structure, so as to achieve the purpose that the transmission gear 112 and the first roller 113 intermittently rotate, the first roller 113 is connected with a second roller 118 by a conveyer belt 115, the driving gear 110 and the transmission gear 112 in the connecting frame 102 to rotate to drive the first roller 113 to move, the first roller 113 is connected with the second roller 118 by a conveyer belt 115, the conveyer belt 115 drives the conveyer belt 118 to move, the conveyer belt 116 to place the slide glass on the slide glass placing box and connect the slide glass placing box 117 by using a plurality of fixed grooves, and the connecting grooves 117 are formed by using a plurality of the connecting grooves 117, and the connecting grooves 117;
meanwhile, a first rotating wheel 114 is fixedly connected to one side of the first roller 113, when the first roller 113 rotates, the first rotating wheel 114 is driven to rotate, the first rotating wheel 114 is connected with a second rotating wheel 120 through a connecting belt 19, so that the second rotating wheel 120 located on the side of the fixing frame 121 is driven to rotate, the second rotating wheel 120 is connected with the pressing roller, the pressing roller and a buffer gasket located on the outer side of the pressing roller are driven to rotate, the height of the bottommost part of the buffer gasket is the same as that of the topmost part of the slide placing box 117, the slide placing box 117 is pressed by the rotation of the buffer gasket, so that the slide placing box 117 is in close contact with the bottom of the connecting groove 116, the slide placing box 117 is located at the same height, the condition that the observation of the subsequent fluorescence microscope 106 is affected due to the difference in height of the slide placing box 117 is effectively avoided, the buffer gasket has certain elasticity, and can deform to a certain degree, and the condition that the slide placing box 117 is damaged due to the mutual extrusion in the process of pressing the slide placing box 117 is effectively avoided;
when the slide glass placing box 117 moves to the position right below the fluorescence microscope 106, the fluorescence microscope 106 is used for observing samples in the slide glass placing box 117, the fluorescence microscope 106 is provided with a plurality of fluorescence microscopes 106, the samples in the slide glass placing boxes 117 can be observed simultaneously, the observation efficiency is improved, when the observation height of the fluorescence microscope 106 needs to be adjusted, the driving motor is controlled to rotate, the driving motor drives the driving gear 110 to rotate, the driving gear 110 is connected with the connecting gear 108 through the chain 109, the connecting gear 108 is provided with two groups, the diameter of the connecting gear 108 is the same as that of the driving gear 110, the rotating lead screw 107 is fixedly connected to the bottom of the connecting gear 108 and the bottom of the driving gear 110, the plurality of groups of rotating lead screws 107 are driven to rotate simultaneously, the rotating lead screw 107 is in threaded connection with the lifting block 104, the lifting block 105 is driven to move on the supporting frame 103, the connecting block 105 is connected with the fluorescence microscope 106 to drive the fluorescence microscope 106 to move, the fluorescence microscope 106 is driven to move, the slide glass microscope placing box 117 is placed in a way, the observation height of the slide glass microscope can be adjusted conveniently and the left imaging microscope imaging device can be taken out when the slide glass placing box 117 is adjusted.
Example two
A working method of an oral mucosa multi-frequency fluorescence imaging system for distinguishing cancerous cells comprises the following steps: detecting the oral mucosa through the fluorescence imaging device body;
displaying the image of the fluorescence imaging body through a display unit;
the fluorescence imaging body is cooled through the cooling unit.
Although the embodiments of the present invention have been described with reference to the accompanying drawings, it is not intended to limit the scope of the present invention, and it should be understood by those skilled in the art that various modifications and variations can be made without inventive efforts by those skilled in the art based on the technical solution of the present invention.

Claims (10)

1. An oral mucosa multi-frequency fluorescence imaging system for cancer cell discrimination is characterized by comprising a fluorescence imaging device body, a display unit and a heat dissipation unit, wherein the fluorescence imaging device body is connected with the display unit, and the display unit is used for displaying an image of the fluorescence imaging device body; the fluorescence imaging body is also connected with a heat dissipation unit, and the heat dissipation unit is used for dissipating heat of the fluorescence imaging body; the heat dissipation unit comprises a heat conduction plate and a protective cover, the heat conduction plate is installed on the protective cover in a penetrating mode, and the protective cover is fixedly connected to the back face of the fluorescence imaging device body.
2. The multi-frequency fluorescence imaging system of claim 1, wherein the end of the thermal conductive plate is mounted with a branching block, and the surface of the branching block is recessed inward to form a groove.
3. The multi-frequency fluorescence imaging system of claim 1, wherein the heat-dissipating unit further comprises a water tank heat-dissipating mechanism, the water tank heat-dissipating mechanism comprising a water tank, a water pump, a suction tube, a drainage tube, a nozzle, a positioning rack, a movable toothed block, a driving impeller, a fixed rod, a return tube, and a baffle.
4. The multi-frequency fluorescence imaging system according to claim 3, wherein the water tank is disposed at left and right sides of the fluorescence imaging apparatus main body, a water pump for water source transmission is installed at an upper end of the water tank, and the water pump and the water tank are connected to each other through a suction pipe.
5. The multi-frequency fluorescence imaging system of claim 3, wherein one end of a drainage tube is connected to a side of the water pump, the other end of the drainage tube is mounted on the nozzle, the nozzle is fixedly connected to the positioning rack, and the positioning rack is connected to the shield through a spring.
6. The multi-frequency fluorescence imaging system of claim 3, wherein the movable tooth block is disposed at a lower end of the positioning rack, the movable tooth block is mounted on a central rod, and a transmission impeller is mounted in a middle portion of the central rod; the upper end of the fixed rod is installed on the central rod, the left side of the lower end of the fixed rod is fixedly connected with a pushing plate, the left end of the pushing plate extends into the metal pipe, and a raised line is installed on the outer side of the metal pipe.
7. The multi-frequency fluorescence imaging system of claim 3, wherein one end of a return tube is disposed at a lower end of the metal tube, and the other end of the return tube is mounted at a side of the water tank; the baffle is installed the inside of tubular metal resonator, through stay cord interconnect between baffle and the beating board, and the rotation axis outside of baffle and beating board all is provided with the torsion spring who provides reset elasticity.
8. The multi-frequency fluorescence imaging system according to claim 1, wherein the fluorescence imaging device body is an oral mucosa imaging device using fluorescence imaging method, and comprises a fixing base, a connecting frame and a support frame, the connecting frame is fixedly connected to the top of the fixing base, the support frame is welded to the top of the connecting frame, a connecting block is nested inside the left side of the support frame, and a fluorescence microscope is fixedly connected to the end of the connecting block.
9. The multi-frequency fluorescence imaging system of claim 8, wherein the fluorescence imaging device body further comprises a rotation gear, a transmission gear, a first roller, a first wheel, and a conveyor belt;
the rotating gear is movably arranged inside the connecting frame, the side of the rotating gear is meshed with a transmission gear, the end part of one side of the transmission gear is fixedly connected with a first rolling roller, and the other end of the first rolling roller is fixedly connected with a first rotating wheel;
the outer side of the first roller is attached and connected with a conveying belt, a connecting groove is formed in the conveying belt, and a slide placing box is mounted in the connecting groove;
the fluorescence imaging device body still includes the mount, the mount install in the right side of support frame, and the outside movable mounting of mount has the second runner to the outside of second runner is connected with the conveyer belt.
10. A method of operating the multi-frequency fluorescence imaging system for the cancer cells differentiation of the oral mucosa according to any one of claims 1 to 9, comprising:
detecting the oral mucosa through the fluorescence imaging device body;
displaying the image of the fluorescence imaging body through a display unit;
the fluorescence imaging body is cooled through the cooling unit.
CN202210886685.9A 2022-07-26 2022-07-26 Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells Pending CN115308176A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210886685.9A CN115308176A (en) 2022-07-26 2022-07-26 Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210886685.9A CN115308176A (en) 2022-07-26 2022-07-26 Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells

Publications (1)

Publication Number Publication Date
CN115308176A true CN115308176A (en) 2022-11-08

Family

ID=83859083

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210886685.9A Pending CN115308176A (en) 2022-07-26 2022-07-26 Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells

Country Status (1)

Country Link
CN (1) CN115308176A (en)

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB190406708A (en) * 1904-03-19 1905-03-09 Philip Middleton Justice Improvements in and connected with Methods of Transmitting Power.
WO1994001968A1 (en) * 1992-07-08 1994-01-20 Oncor, Inc. Low light color imaging system with cooled integrating camera
KR19990032844U (en) * 1997-12-31 1999-07-26 정몽규 Gear Water Pump
WO2001040760A1 (en) * 1999-11-30 2001-06-07 Active Biotech Ab System and method for processing tissue section samples
KR20110063112A (en) * 2009-12-04 2011-06-10 현대자동차주식회사 Variable water pump
US20120133756A1 (en) * 2010-11-30 2012-05-31 Robert Levin Compact, high-resolution fluorescence and brightfield microscope and methods of use
US20180156713A1 (en) * 2016-12-06 2018-06-07 Abbott Laboratories Automated Slide Assessments and Tracking in Digital Microscopy
CN108919476A (en) * 2018-04-29 2018-11-30 中国华录集团有限公司 A kind of iridescent wheel cap assemblies for strengthening heat sinking function
CN110492720A (en) * 2019-08-21 2019-11-22 大唐东营发电有限公司 A kind of high-voltage frequency converters in power plants refrigeration radiating system
CN111419194A (en) * 2020-04-30 2020-07-17 山东大学 Fluorescent laser and OCT (optical coherence tomography) -based combined imaging device and method
CN213366153U (en) * 2020-11-13 2021-06-04 暨南大学 Medical image imaging device
CN113507031A (en) * 2021-05-27 2021-10-15 山东大学 Light source device based on fluorescent crystal pumping optical waveguide
CN113670880A (en) * 2021-08-27 2021-11-19 南京大学 Fluorescence microscopic imaging device and imaging method
JP7003351B1 (en) * 2020-07-22 2022-01-20 杭州盛恋網絡科技有限公司 Protective case for RF repeater equipment with heat dissipation unit
CN113970535A (en) * 2021-10-18 2022-01-25 广州市微米生物科技有限公司 Detector and using method thereof
EP3957482A1 (en) * 2020-08-19 2022-02-23 Shenzhen Dongfangshitong Technology Development Co.,Ltd. Glass slide printer

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB190406708A (en) * 1904-03-19 1905-03-09 Philip Middleton Justice Improvements in and connected with Methods of Transmitting Power.
WO1994001968A1 (en) * 1992-07-08 1994-01-20 Oncor, Inc. Low light color imaging system with cooled integrating camera
KR19990032844U (en) * 1997-12-31 1999-07-26 정몽규 Gear Water Pump
WO2001040760A1 (en) * 1999-11-30 2001-06-07 Active Biotech Ab System and method for processing tissue section samples
KR20110063112A (en) * 2009-12-04 2011-06-10 현대자동차주식회사 Variable water pump
US20120133756A1 (en) * 2010-11-30 2012-05-31 Robert Levin Compact, high-resolution fluorescence and brightfield microscope and methods of use
US20180156713A1 (en) * 2016-12-06 2018-06-07 Abbott Laboratories Automated Slide Assessments and Tracking in Digital Microscopy
CN108919476A (en) * 2018-04-29 2018-11-30 中国华录集团有限公司 A kind of iridescent wheel cap assemblies for strengthening heat sinking function
CN110492720A (en) * 2019-08-21 2019-11-22 大唐东营发电有限公司 A kind of high-voltage frequency converters in power plants refrigeration radiating system
CN111419194A (en) * 2020-04-30 2020-07-17 山东大学 Fluorescent laser and OCT (optical coherence tomography) -based combined imaging device and method
JP7003351B1 (en) * 2020-07-22 2022-01-20 杭州盛恋網絡科技有限公司 Protective case for RF repeater equipment with heat dissipation unit
EP3957482A1 (en) * 2020-08-19 2022-02-23 Shenzhen Dongfangshitong Technology Development Co.,Ltd. Glass slide printer
CN213366153U (en) * 2020-11-13 2021-06-04 暨南大学 Medical image imaging device
CN113507031A (en) * 2021-05-27 2021-10-15 山东大学 Light source device based on fluorescent crystal pumping optical waveguide
CN113670880A (en) * 2021-08-27 2021-11-19 南京大学 Fluorescence microscopic imaging device and imaging method
CN113970535A (en) * 2021-10-18 2022-01-25 广州市微米生物科技有限公司 Detector and using method thereof

Similar Documents

Publication Publication Date Title
CN115308176A (en) Oral mucosa multi-frequency fluorescence imaging system and method for distinguishing cancerous cells
CN113951937B (en) Oral mucus collection device for classical swine fever virus PCR detection
CN111214683A (en) Adjustable otolaryngology is clinical with scope degassing unit
CN106455437A (en) Quick heat radiation device for internet network cabinet
CN116035158A (en) Lifting type thawing machine for food marinating production and using method thereof
CN209669288U (en) A kind of aluminum alloy section quenching device
CN212341613U (en) Projection arrangement for radiology department
CN211149379U (en) Computer CPU radiator device of decontaminating
CN219366646U (en) Brake with good friction performance
CN209734895U (en) Adjustable volleyball net support
CN208334012U (en) A kind of blood smearing machine
CN113171120A (en) Auxiliary diagnosis display device for medical ultrasonic instrument
CN113446282A (en) Hydraulic press hydro-cylinder
CN111759268A (en) Stomach is peritoneoscope for surgery
CN220472158U (en) Instrument drying device that multi-angle toasted
CN115175548B (en) X fluorescence spectrometer for stainless steel product composition analysis
CN218414669U (en) Heat dissipation structure of flow battery system
CN115227208B (en) Oral cavity cancer cell identification device and method based on fluorescence imaging principle
CN220252308U (en) Protection device for preventing X-ray irradiation
CN220820609U (en) Display heat radiation equipment
CN219895697U (en) Electric hanging bracket device convenient for fixing bronchofiberscope
CN220025002U (en) Ear-nose-throat diagnosis and treatment table is with preheating defogging device
CN217070463U (en) High-speed stamping die with cooling mechanism
CN219042328U (en) Laser interferometer capable of avoiding overheating
CN218853508U (en) Ammonium acetate crystallization equipment

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination