CN115305215A - 乳杆菌属的新型细菌发酵剂 - Google Patents
乳杆菌属的新型细菌发酵剂 Download PDFInfo
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- CN115305215A CN115305215A CN202210500041.1A CN202210500041A CN115305215A CN 115305215 A CN115305215 A CN 115305215A CN 202210500041 A CN202210500041 A CN 202210500041A CN 115305215 A CN115305215 A CN 115305215A
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Abstract
本发明涉及一种细菌发酵剂,其通过包括或由以下步骤组成的方法获得:(a)在至少一种生长培养基中培养乳杆菌属至少24小时;(b)通过离心分离混合物;(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;(d)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和任选地(e)过滤混合物以除去任何最终沉淀物。
Description
技术领域
本发明涉及乳杆菌属的细菌发酵剂、获得该细菌发酵剂的方法及其在化妆品和药物应用中的用途。
背景技术
产生乳酸的细菌以及相关生物的大型生态系统对于食品、人类保健和工业应用具有商业重要性。乳酸菌商业价值的一些最广为人知的例子与它们保存食品和奶制品,如酸菜、酸奶和奶酪的能力有关。其他应用包括发酵草以生产青贮饲料,这是一种持久且重要的冬季动物饲料。
最近,特定乳酸菌的特定混合物已作为益生菌以高浓度直接食用。使用益生菌补充剂是改善人类健康和影响特定症状的新方法。该策略是影响宿主的微生物组,而不是用常规药物直接干预宿主细胞的生物化学。这种方法与人们日益认识到人类(实际上很可能是地球上的所有生物)的共生微生物组是影响宿主健康的关键因素相吻合。微生物组的影响以及微生物组与其宿主的相互作用不仅限于细菌数量非常高的身体区域,例如肠道,而且在人体遇到微生物的任何区域都非常重要。随着用于皮肤应用的较少人工或“类药物”化学物质的增长趋势,使用益生菌衍生产品的生物方法化妆品的商业潜力是显着的。由于益生菌的安全使用历史非常悠久,不是合成化学品,而且它们本身已经是共生微生物组的组成部分,因此受到消费者的好评。
产生简单酸的细菌,如乳酸(因此乳酸菌和细菌属乳杆菌)可以通过将简单的糖转化为酸并将pH降低到4左右来酸化周围环境。这是细菌可以控制它们环境的最简单的机制,因为pH值的快速下降使其他生物更难竞争,因此“破坏”周围环境或食物。乳酸菌还具有通过直接将生物活性分子释放到周围环境中来产生各种类型的化合物来控制其环境的能力,这些化合物直接作用于宿主生物或其他细菌。这些可以是蛋白质、肽、乙二醇肽、大型复杂多糖或其他通过不同于pH改变的机制发挥作用的小分子。这些释放到细胞外环境中的分泌因子通常也可以描述为分泌组,分泌组的功能通常被认为与以下因素相关:1)与环境中的其他生物相互作用,(2)细胞外复合营养素的识别、结合、降解和摄取,(3)信号转导,(4)与环境的交流,以及(5)细菌细胞与特定位点或表面的附着,例如:寄主的肠黏膜细胞。
在制造任何益生菌的过程中,超过90%的生长培养基通常被丢弃,因为益生菌在离心过程中与生长培养基分离。通过离心分离的固体材料通常被称为益生菌,或者如果它被裂解,则称为益生菌裂解物,该过程通常用于化妆品应用。可以将生长培养基转化为本领域中通常被称为发酵剂的产品。显然,从生长培养基中生产有用的产品反映了提高制造效率并且通过将围绕数万亿活益生菌的培养基转化为产品限制了制造过程中废物产生的机会,从而降低商品的总成本,即使随后的下游处理步骤可能会增加一些额外的成本。
这种方法并非没有商业先例,因为基于来自乳酸菌发酵剂和发酵酵母的生长培养基的产品存在或之前已经商业化。乳杆菌发酵剂是一种成熟的成分,被国际化妆品成分命名法(INCI)认可。另一个实例是以SK-II品牌销售的Pitera产品,一种酵母发酵产品。Pitera产品的营销突出了发酵过程中的安全性、天然作用以及不含防腐剂。
存在可用作产生各种类型发酵剂的起始材料的潜在细菌和其他微生物(例如酵母和真菌)的广阔生态系统。这些微生物中的每一种都可以产生非常不同规格的发酵剂,并且这些发酵剂中的每一种可能需要以特定方式生产以保持所需的生物活性并确保发酵剂对于其预期应用是稳定的。
发明目的
然而,任何微生物发酵剂生产的挑战是三方面的:首先,发酵剂来源于支持多种微生物生长的生长培养基。因此,除非应用特定工艺来防止微生物进一步生长和发酵剂快速变质,否则该产品本质上是微生物不稳定的。在生产过程中,通过确保生长培养基的完全无菌和仅使用仅包含益生菌且不含污染微生物的精确定义的微生物接种物来防止和控制腐败。然而,由于最终发酵产品希望用于广泛的商业应用,因此细菌生长培养基必须经过额外的处理,以确保其对于预期用途是稳定的,并且产品的美学特性满足市场需求。
其次,发酵剂的美学特性需要在不使用刺激性化学物质的情况下进行调整。调整细菌生长培养基的颜色和气味对于商业可行性很重要,因为支持益生菌生长的细菌生长培养基通常是棕色或深棕色,并且可能具有令人不快的气味或硫磺气味。对于化妆品成分应用,需要较浅的颜色,并且对于几乎任何人类使用的应用,重要的是避免令人不快的产品气味。
第三,管理化妆品成分使用的监管环境通常要求产品的细菌总数为每克100个或更少。在生产时,细菌发酵剂的细菌计数通常超过每克一万亿个细菌。因此,要将这种材料转化为满足活细菌法规要求的产品,需要将活菌数减少超过9个数量级。这是一个主要的技术障碍,因为本领域内几乎所有的灭菌技术通常仅固定地将到细菌数量减少六个数量级,并且大多数灭菌技术采用化学或物理过程,这一过程会破坏细菌释放到其环境中的化合物。
因此,本发明的目的是解决细菌发酵剂生产的产品稳定性问题,同时保持最大的生物活性并避免使用可能对产品特性产生不利影响的刺激性化学品或添加剂。
发明内容
该目的通过根据本发明的权利要求来解决。本发明描述了一种乳杆菌属细菌发酵剂,其通过包括以下步骤的方法获得:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和
(e)任选地过滤混合物以除去任何最终沉淀物。
令人惊讶地发现,使用根据本发明的方法可以获得具有最少或不残留微生物计数的细菌发酵剂,其保留了对于化妆品和人类健康应用具有商业价值的生物活性。
此外,发现通过本发明的方法获得的细菌发酵剂由于与乳酸的短暂pH冲击可以非常有效地灭菌,这导致细菌计数减少至少9个数量级(步骤C)。相比之下,使用加热或灭菌等传统方法,通常可以得到5到6个数量级的减少。然而,这是非常令人惊讶的,因为预计乳杆菌对乳酸具有抗性。因此,根据本发明的细菌发酵剂仍然是活性的,具有理想的颜色和非常低的细菌计数。
本发明还涉及一种生产乳杆菌属细菌发酵剂的方法,包括以下步骤:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)通过添加至少一种防腐剂稳定所得混合物;和任选地
(e)过滤混合物以除去任何最终沉淀物。
在根据本发明的一个优选实施方案中,生长培养基包含酵母提取物、酵母蛋白胨、乙酸钠、右旋糖、蔗糖、柠檬酸铵、磷酸钾、抗坏血酸、L-半胱氨酸、硫酸镁、吐温-80和/或水的混合物。
在根据本发明的进一步优选实施方案中,将混合物与至少一种不同乳杆菌属的其他混合物组合,该其他混合物使用相同的培养方法、通过离心分离并添加乳酸,随后通过加入至少一种防腐剂稳定所得混合物进行制备,从而生产不同乳杆菌属材料的混合物。这个额外的优选步骤是有益的,因为由于这种组合,细菌发酵剂中包含了不同乳杆菌菌株的不同活性物质。
在本发明的另一个优选实施方案中,通过添加至少一种多功能剂或多功能化合物来稳定所得混合物。多功能剂或多功能化合物是增强活性成分性能、改善配方美感(包括色素的可分散性)、稳定乳液、充当增溶剂或保湿剂并且还提供产品保护的化合物或物质。这些多功能剂有助于消除成分的总数,同时最大限度地提高配方优势并优化消费者体验。在本发明上下文中的多功能剂或多功能化合物优选为多元醇,特别是二元醇,如1,2-丙二醇(丙二醇)、1,3-丙二醇、1,2-丁二醇、1,3-丁二醇(丁二醇)、1,2-戊二醇(戊二醇;5;绿色版本或任何等级)、1,2-己二醇(6)、1,2-庚二醇、1,2-辛二醇(辛二醇;8)、1,2-壬二醇、1,2-癸二醇(癸二醇)、或甘油、苯氧乙醇、乙基己基甘油、辛酸甘油酯、羟基苯乙酮、甲基苄醇、O-伞花烃-5-醇、苯甲醇、托酚酮或两种或多种所述多功能剂的混合物,它们是通常用作化妆品或药物制剂成分的已知化合物.
在上述多功能成分中,特别优选例如提高活性成分性能、改善配方感官特征和增强产品保护的二醇。
优选地,根据本发明的化妆品或药物制剂还可以包含用于防腐目的的活性化合物,其中可以使用适合或常用于化妆品或药物,特别是皮肤病学应用的任何防腐剂。在本发明的另一个优选实施方案中,通过添加至少一种防腐剂来稳定所得混合物。防腐剂有利地选自防腐剂,例如尤其是苯甲酸、其酯和盐;丙酸及其盐;水杨酸及其盐;2,4-己酸(山梨酸)及其盐;甲醛和多聚甲醛;2-羟基联苯醚及其盐;2-锌硫代吡啶N-氧化物;无机亚硫酸盐和亚硫酸氢盐;碘酸钠;氯丁醇;4-羟基苯甲酸及其盐和酯;脱氢乙酸;甲酸;1,6-双(4-脒基-2-溴苯氧基)-正己烷及其盐;乙基汞-(II)-硫代水杨酸的钠盐;苯汞及其盐类;10-十一碳烯酸及其盐;5-氨基-1,3-双(2-乙基己基)-5-甲基六氢嘧啶;5-溴-5-硝基-1,3-二恶烷;2-溴-2-硝基-1,3-丙二醇;2,4-二氯苄醇;N-(4-氯苯基)-N'-(3,4-二氯苯基)脲;4-氯间甲酚;2,4,4'-三氯-2'-羟基-二苯醚;4-氯-3,5-二甲基苯酚;1,1'-亚甲基-双(3-(1-羟甲基-2,4-二氧代咪唑烷-5-基)脲);聚(六亚甲基双胍)盐酸盐;2-苯氧乙醇;六亚甲基四胺;1-(3-氯代烯丙基)-3,5,7-三氮杂-1-氮翁金刚烷氯化物;1-(4-氯-苯氧基)-1(1H-咪唑-1-基)-3,3-二甲基-2-丁酮;1,3-双(羟甲基)-5,5-二甲基-2,4-咪唑烷二酮;苯甲醇;1,2-二溴-2,4-二氰基丁烷;2,2'-亚甲基-双(6-溴-4-氯-苯酚);溴氯酚;5-氯-2-甲基-3(2H)-异噻唑啉酮和2-甲基-3(2H)异噻唑啉酮与氯化镁和硝酸镁的混合物;2-苄基-4-氯苯酚;2-氯乙酰胺;氯己定;醋酸氯己定;葡萄糖酸氯己定;盐酸氯己定;1-苯氧基-丙-2-醇;N-烷基(C12-C22)三甲基溴化铵和氯化铵;4,4-二甲基-1,3-恶唑烷;N-羟甲基-N-(1,3-二(羟甲基)-2,5-二氧代咪唑啉-4-基)-N'-羟甲基脲;1,6-双(4-脒基苯氧基)-正己烷及其盐;戊二醛;5-乙基-1-氮杂-3,7-二氧杂双环(3.3.0)辛烷;3-(4-氯苯氧基)-1,2-丙二醇;季铵盐;烷基(C8-C18)二甲基苄基氯化铵;烷基(C8-C18)二甲基苄基溴化铵;烷基(C8-C18)二甲基苄基糖精铵;苄基半缩醛;丁基氨基甲酸3-碘-2-丙炔酯;((羟甲基)氨基)乙酸钠。
由于该属(乳杆菌)的分类学最近已被分类小组委员会(负责命名乳杆菌的科学组织)改变,本发明还指以下任何属:乳杆菌属、Lactobacillus delbrueckii group、副乳杆菌属、Holzapfelia、Amylolactobacillus、Bombilactobacillus、Companilactobacillus、Lapidilactobacillus、Agrilactobacillus、Schleiferilactobacillus、Loigolactobacilus、Lacticaseibacillus、Latilactobacillus、Dellaglioa、Liquorilactobacillus、Ligilactobacillus、Lactiplantibacillus、Furfurilactobacillus、Paucilactobacillus、Limosilactobacillus、Fructilactobacillus、Acetilactobacillus、Apilactobacillus、Levilactobacillus、Secundilactobacillus和Lentilactobacillus。
在根据本发明的进一步优选的实施方案中,乳杆菌物种选自组包括嗜酸乳杆菌(Lactobacillus acidophilus)、干酪乳杆菌(Lactobacillus casei)、发酵乳杆菌(Lactobacillus fermentum)、格氏乳杆菌(Lactobacillus gasseri)、瑞士乳杆菌(Lactobacillus helvet-icus)、副干酪乳杆菌(Lactobacillus paracasei)、植物乳杆菌(Lactobacillus plantarum)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、清酒乳杆菌(Lactobacillus sakei)和唾液乳杆菌(Lactobacillus salivarius)。
优选地,基于混合物的总量,乳酸的添加量为2至10重量%。更优选地,基于混合物的总量,乳酸的添加量为4至7重量%。
优选地,根据本发明的方法包括以下步骤:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)向所得混合物中加入固态和/或水溶液苯甲酸钠;
(e)将混合物孵育至少12小时;
(f)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和任选地
(g)过滤混合物以除去任何最终沉淀物。
更优选地,根据本发明的方法包括以下步骤:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)向所得混合物中加入固态和/或水溶液苯甲酸钠;
(e)将混合物孵育至少12小时;
(f)使混合物通过碳过滤器:
(g)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和任选地
(h)过滤混合物以除去任何最终沉淀物。
在根据本发明的优选实施例中,碳过滤器是活化和/或催化碳过滤器。更优选地,根据本发明的方法包括或由以下步骤组成:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)向所得混合物中加入固态和/或水溶液苯甲酸钠;任选地
(e)将该混合物与至少一种不同乳杆菌物种的其他混合物,其用相同的培养、离心分离和添加乳酸和/或固态和/或水溶液苯甲酸钠的方法制备,混合
(f)分析混合物以测量细菌计数和pH值;
(g)将混合物孵育至少12小时;
(h)使混合物通过碳过滤器:
(i)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;
(j)加入适量的氢氧化铵调节pH值;并且任选地
(k)通过离心过滤和/或分离混合物以去除任何最终沉淀。
在根据本发明的一个优选实施方案中,向混合物添加乳酸导致pH冲击,这导致细菌计数减少9个数量级。本发明意义上的pH冲击是混合物的pH在短时间内快速变化。优选地,pH值降低了0.5至4.5,更优选1至4,最优选2至3.5。在根据本发明的优选实施方案中,添加乳酸之前的初始pH值为约5至7,优选约5.5至6.5。
化妆品和/或药物组合物
根据另一方面,本发明还涉及药物或化妆品组合物或药物或化妆品产品,其包含工作量的细菌发酵剂,例如约0.1至约10重量%,优选约0.5至约8重量%,特别是约1至约5重量%——按组合物计算。该组合物可以代表例如美容霜、洗剂、喷雾剂、乳液、软膏、凝胶或摩丝等。
根据本发明的制剂可以含有去头屑剂、防刺激剂、抑制刺激剂,抗氧化剂、收敛剂、抑汗剂、杀菌剂、抗静电剂、粘合剂、缓冲剂、载体、螯合剂、细胞刺激剂、清洗剂、护理剂、除臭剂、止汗剂、软化剂、乳化剂、酶、精油、纤维、成膜剂、固色剂、泡沫形成剂、泡沫稳定剂、消泡剂、泡沫促进剂、胶凝剂、凝胶形成剂、头发护理剂、毛发定型剂、头发拉直剂、增湿剂、润湿剂、保湿剂、漂白剂、加强剂、驱污剂、光学增亮剂、浸溃剂、驱污剂、减摩剂、润滑剂、保湿霜、软膏、遮光剂、增塑剂、覆盖剂、上光剂、光泽剂、聚合物、粉末、蛋白质、加脂剂(re-oiling agents)、磨蚀剂、硅酮、育发剂、冷却剂、皮肤冷却剂、加温剂、皮肤升温剂、稳定剂、紫外线吸收剂、UV滤光剂、洗涤剂、增稠剂、维生素、油、蜡、脂肪、磷脂、饱和脂肪酸、单或多不饱和脂肪酸、α-羟基酸、多羟基脂肪酸、液化剂、染料、颜色保护剂、颜料、芳香物质、多元醇、表面活性剂、电解质、有机溶剂或硅酮衍生物等作为额外助剂和添加剂。
表面活性剂
优选的助剂和添加剂是阴离子和/或两性或两性离子表面活性剂。非离子和阳离子表面活性剂也可以存在于组合物中。合适的例子与涉及乳化剂的段落一起提到。
阴离子和两性离子表面活性剂的典型例子包括:杏仁油酰胺丙基胺氧化物、杏仁油酰胺丙基甜菜碱、氨丙基月桂基谷氨酰胺、C12-15烷醇硫酸酯铵、C12-16烷醇硫酸酯铵、辛醇聚醚硫酸酯铵、单椰油酸甘油酯硫酸铵、椰油醇硫酸酯铵、椰油酰羟乙磺铵、椰油酰肌氨酸铵、C12-15链烷醇聚醚硫酸酯铵、C9-10全氟代烷基磺酸铵、磺基琥珀酸二壬酯铵、十二烷基苯磺酸铵、异硬脂酸铵、月桂醇聚醚-6羧酸铵、月桂醇聚醚-8羧酸铵、月桂醇聚醚硫酸酯铵、月桂醇聚醚-5硫酸酯铵、月桂醇聚醚-7硫酸酯铵、月桂醇聚醚-9硫酸酯铵、月桂醇聚醚-12硫酸酯铵、月桂酰肌氨酸铵、月桂醇硫酸酯铵、月桂醇磺基琥珀酸酯铵、肉豆蔻醇聚醚硫酸酯铵、肉豆蔻基硫酸铵、壬基苯酚聚醚-4硫酸酯铵、壬基苯酚聚醚-30硫酸酯铵、油酸铵、棕榈仁油醇硫酸酯铵、硬脂酸铵、妥尔油酸铵、异硬脂酰水解胶原AMPD盐、松香(酰)水解胶原AMPD盐、异硬脂酰水解胶原AMP盐、异硬脂酰水解角蛋白AMP盐、异硬脂酰水解大豆蛋白AMP盐、异硬脂酰水解小麦蛋白AMP盐、野杏油酰胺基丙基甜菜碱、花生酸、己基癸醇磷酸酯精氨酸盐、鳄梨油酰胺丙基甜菜碱、鳄梨油甘油聚醚-8酯类、巴巴苏籽油酸、巴巴苏油酰胺丙基胺氧化物、巴巴苏油酰胺丙基甜菜碱、蜂蜡酸、山嵛酰胺丙基甜菜碱、山嵛胺氧化物、山嵛醇聚醚-25、山嵛醇聚醚-30、山嵛酸、山嵛基甜菜碱、双-丁基聚二甲基硅氧烷聚甘油-3、丁基苯酚聚醚-5羧酸、丁基苯酚聚醚-19羧酸、丁基二甲基(羟丙基丁基葡糖苷)氯化铵、丁基二甲基(羟丙基月桂基葡糖苷)氯化铵、丁基葡糖苷、丁基葡糖苷癸酸酯、丁基葡糖苷类羟丙基三甲基氯化铵、丁基辛酸、C18-36酸、C20-40酸、C30-50酸、C16-22酸酰胺MEA、十二烷基苯磺酸钙、月桂酰牛磺酸钙、C9-16烷/环烷、C10-14烷基苯磺酸、C12-14烷基二(氨基乙基)甘氨酸HCl、C9-15醇磷酸酯、假丝酵母/葡萄糖/油菜籽油酸甲酯发酵产物、低芥酸菜子油酰胺丙基甜菜碱、癸酸、己酸、己酰基乙基葡糖苷、辛酰/癸酰氨丙基甜菜碱、辛醇聚醚-4羧酸、辛醇聚醚-6羧酸、辛醇聚醚-9羧酸、辛酸、辛酰胶原氨基酸类、辛酰甘氨酸、辛酰水解胶原、辛酰水解角蛋白、辛酰角蛋白氨基酸类、辛酰蚕丝氨基酸类、辛基/癸基葡糖苷、辛基/癸基小麦麸/秸苷类、辛基葡糖苷、辛基甘油基醚、辛基吡咯烷酮、肉碱、鲸蜡硬脂醇聚醚-20、鲸蜡硬脂醇聚醚-23、鲸蜡硬脂醇聚醚-24、鲸蜡硬脂醇聚醚-25、鲸蜡硬脂醇聚醚-27、鲸蜡硬脂醇聚醚-28、鲸蜡硬脂醇聚醚-29、鲸蜡硬脂醇聚醚-30、鲸蜡硬脂醇聚醚-33、鲸蜡硬脂醇聚醚-34、鲸蜡硬脂醇聚醚-40、鲸蜡硬脂醇聚醚-50、鲸蜡硬脂醇聚醚-55、鲸蜡硬脂醇聚醚-60、鲸蜡硬脂醇聚醚-80、鲸蜡硬脂醇聚醚-100、鲸蜡硬脂醇聚醚-25羧酸、鲸蜡硬脂醇聚醚-2磷酸酯、鲸蜡硬脂醇聚醚-4磷酸酯、鲸蜡硬脂醇聚醚-5磷酸酯、二鲸蜡硬脂醇聚醚-10磷酸酯、鲸蜡醇聚醚-20、鲸蜡醇聚醚-23、鲸蜡醇聚醚-24、鲸蜡醇聚醚-25、鲸蜡醇聚醚-30、鲸蜡醇聚醚-40、鲸蜡醇聚醚-45、鲸蜡醇聚醚-150、鲸蜡醇聚醚-8磷酸酯、鲸蜡醇聚醚-10磷酸酯、鲸蜡醇聚醚-20磷酸酯、鲸蜡油醇聚醚-22、鲸蜡油醇聚醚-24、鲸蜡油醇聚醚-25、鲸蜡油醇聚醚-30、鲸蜡基甜菜碱、毛华菊(CHRYSANTHEMUM SINENSE)花提取物、C12-14羟烷基羟乙基β-丙氨酸、C12-14羟烷基羟乙基肌氨酸、椰油酰胺乙基甜菜碱、椰油酰胺丙基胺氧化物、椰油酰胺丙基甜菜碱酰胺MEA氯化物、椰油酰胺丙基甜菜碱、椰油酰胺丙基羟基磺基甜菜碱、椰油胺氧化物、椰油氨基丁酸、椰油氨基丙酸、椰油醇聚醚-7羧酸、椰油醇聚醚-4葡糖苷、椰油酰两性基丙酸、椰油基甜菜碱酰胺基两性基丙酸盐、椰油基甜菜碱、椰油基二甲基铵羟丙基水解大米蛋白、椰油基二甲基铵羟丙基水解大豆蛋白、椰油基二甲基铵羟丙基水解小麦蛋白、椰油基葡糖苷、椰油基葡糖苷羟丙基三甲基氯化铵、椰油基羟基磺基甜菜碱、椰油基吗啉氧化物、椰油酸、椰子油甘油聚醚-8酯类、椰油酰/油酰胺丙基甜菜碱、椰油基-磺基甜菜碱、(椰油/葵花籽油)酰胺丙基甜菜碱、椰油酰胆碱甲基硫酸盐、椰油酰谷氨酸、椰油酰基水解胶原、椰油酰基水解角蛋白、椰油酰基水解燕麦蛋白、椰油酰水解大米蛋白、椰油酰基水解蚕丝、椰油酰基水解大豆蛋白、椰油酰基水解小麦蛋白、椰油酰肌氨酸、玉米油脂酸、棉籽油酸、棉籽油甘油聚醚-8酯类、C10-16链烷醇聚醚-1、C10-16链烷醇聚醚-2、C11-13链烷醇聚醚-6、C11-13链烷醇聚醚-9、C11-13链烷醇聚醚-10、C11-15链烷醇聚醚-30、C11-15链烷醇聚醚-40、C12-13链烷醇聚醚-1、C12-13链烷醇聚醚-23、C12-14链烷醇聚醚-5、C12-14链烷醇聚醚-9、C13-15链烷醇聚醚-21、C14-15链烷醇聚醚-8、C20-22链烷醇聚醚-30、C20-40链烷醇聚醚-40、C20-40链烷醇聚醚-95、C22-24链烷醇聚醚-33、C30-50链烷醇聚醚-40、C9-11链烷醇聚醚-6羧酸、C9-11链烷醇聚醚-8羧酸、C11-15链烷醇聚醚-7羧酸、C12-13链烷醇聚醚-5羧酸、C12-13链烷醇聚醚-7羧酸、C12-13链烷醇聚醚-8羧酸、C12-13链烷醇聚醚-12羧酸、C12-15链烷醇聚醚-7羧酸、C12-15链烷醇聚醚-8羧酸、C12-15链烷醇聚醚-12羧酸、C14-15链烷醇聚醚-8羧酸、C6-10链烷醇聚醚-4磷酸酯、C12-13链烷醇聚醚-2磷酸酯、C12-13链烷醇聚醚-10磷酸酯、C12-15链烷醇聚醚-6磷酸酯、C12-15链烷醇聚醚-8磷酸酯、C12-15链烷醇聚醚-10磷酸酯、C12-16链烷醇聚醚-6磷酸酯、C4-18全氟代烷基乙基巯丙基三甲基氯化铵、大花可可脂肪酰胺丙基甜菜碱、C12-13醇硫酸酯DEA盐、C12-15醇硫酸酯DEA盐、鲸蜡硬脂醇聚醚-2磷酸酯DEA盐、鲸蜡醇硫酸酯DEA盐、椰油酰两性基二丙酸DEA盐、C12-13链烷醇聚醚-3硫酸酯DEA盐、环羧丙基油酸DEA盐、十二烷基苯磺酸DEA盐、异硬脂酸DEA盐、月桂醇聚醚硫酸酯DEA盐、月桂醇硫酸酯DEA盐、亚油酸DEA盐、肉豆蔻酸甲酯磺酸DEA盐、肉豆蔻醇醚硫酸酯DEA盐、肉豆蔻酸DEA盐、肉豆蔻醇硫酸酯DEA盐、油醇聚醚-5磷酸酯DEA盐、油醇聚醚-20磷酸酯DEA盐、DEA PG-油酸酯、癸醇聚醚-7羧酸、癸醇聚醚-7葡糖苷、癸醇聚醚-9磷酸酯、癸基胺氧化物、癸基甜菜碱、十一烷基葡糖苷、癸基十四醇聚醚-30、癸基十四胺氧化物、月桂酰胺-MEA磺基琥珀酸酯二铵、月桂醇磺基琥珀酸酯二铵、油酰胺基PEG-2磺基琥珀酸酯二铵、二丁氧基甲烷、二C12-15链烷醇聚醚-2磷酸酯、二C12-15链烷醇聚醚-4磷酸酯、二C12-15链烷醇聚醚-6磷酸酯、二C12-15链烷醇聚醚-8磷酸酯、二C12-15链烷醇聚醚-10磷酸酯、双十二醇丁烷四甲酸酯、月桂醇聚醚硫酸酯二乙胺盐、磺基琥珀酸二乙基己酯钠、二(羟乙基)C8-10烷氧丙基胺氧化物、二(羟乙基)C9-11烷氧丙基胺氧化物、二(羟乙基)C12-15烷氧丙基胺氧化物、二(羟乙基)椰油胺氧化物、二(羟乙基)月桂基胺氧化物、二(羟乙基)硬脂胺氧化物、二(羟乙基)牛脂基胺氧化物、聚二甲基硅氧烷PEG-7磷酸酯、聚二甲基硅氧烷PEG-10磷酸酯、聚二甲基硅氧烷PEG/PPG-7/4磷酸酯、聚二甲基硅氧烷PEG/PPG-12/4磷酸酯、聚二甲基硅氧烷/聚甘油-3交联聚合物、聚二甲基硅氧烷丙基PG-甜菜碱、二肉豆蔻醇磷酸酯、二油酰胺乙基羟乙基甲基铵甲基硫酸盐、氢化椰油酸DIPA盐、羊毛脂酸DIPA盐、肉豆蔻酸DIPA盐、辛酰谷氨酸二钾、月桂醇磺基琥珀酸酯二钾、十一碳烯酰谷氨酸二钾、巴巴苏油酰胺基MEA-磺基琥珀酸二钠、癸酰两性基二乙酸二钠、癸酰两性基二丙酸二钠、辛酰两性基二乙酸二钠、辛酰两性基二丙酸二钠、辛酰谷氨酸二钠、鲸蜡硬脂醇磺基琥珀酸酯二钠、鲸蜡基苯基醚二磺酸二钠、鲸蜡醇磺基琥珀酸酯二钠、椰油酰胺基MEA-磺基琥珀酸酯二钠、椰油酰胺基MIPA PEG-4磺基琥珀酸酯二钠、椰油酰胺基MIPA-磺基琥珀酸酯二钠、椰油酰胺基PEG-3磺基琥珀酸酯二钠、椰油醇聚醚-3磺基琥珀酸酯二钠、椰油酰两性基羧乙基羟丙基磺酸二钠、椰油酰两性基二乙酸二钠、椰油酰两性基二丙酸二钠、椰油基-葡糖苷磺基琥珀酸酯二钠、椰油基-磺基琥珀酸酯二钠、椰油酰基丁基葡糖醇聚醚-10磺基琥珀酸酯二钠、椰油酰谷氨酸二钠、C12-14链烷醇聚醚-1磺基琥珀酸酯二钠、C12-14链烷醇聚醚-2磺基琥珀酸酯二钠、C12-15链烷醇聚醚磺基琥珀酸酯二钠、C12-14仲链烷醇聚醚-3磺基琥珀酸酯二钠、C12-14仲链烷醇聚醚-5磺基琥珀酸酯二钠、C12-14仲链烷醇聚醚-7磺基琥珀酸酯二钠、C12-14仲链烷醇聚醚-9磺基琥珀酸酯二钠、C12-14仲链烷醇聚醚-12磺基琥珀酸酯二钠、癸醇聚醚-5磺基琥珀酸酯二钠、癸醇聚醚-6磺基琥珀酸酯二钠、癸基苯基醚二磺酸二钠、二羟乙基磺基琥珀酰十一烯酸二钠、二椰油酰乙二胺PEG-15二硫酸酯二钠、氢化棉籽油甘油酯磺基琥珀酸酯二钠、氢化牛脂酰谷氨酸二钠、羟癸基山梨醇柠檬酸酯二钠、磺基琥珀酸异癸酯二钠、异硬脂酰胺MEA-磺基琥珀酸二钠、异硬脂酰胺MIPA-MEA-磺基琥珀酸二钠、异硬脂两性基二乙酸二钠、异硬脂两性基二丙酸二钠、异硬脂基磺基琥珀酸二钠、羊毛脂醇醚-5磺基琥珀酸酯二钠、月桂酰胺基MEA-磺基琥珀酸酯二钠、月桂酰胺基MIPA乙二醇磺基琥珀酸酯二钠、月桂酰胺基PEG-2磺基琥珀酸酯二钠、月桂酰胺基PEG-5磺基琥珀酸酯二钠、月桂醇聚醚-5羧基两性基二乙酸二钠、月桂醇聚醚-7柠檬酸酯二钠、月桂醇聚醚磺基琥珀酸酯二钠、月桂醇聚醚-6磺基琥珀酸酯二钠、月桂醇聚醚-9磺基琥珀酸酯二钠、月桂醇聚醚-12磺基琥珀酸酯二钠、月桂亚氨基双羟丙基磺酸二钠、月桂亚氨基二乙酸二钠、月桂亚氨基二丙酸二钠、月桂亚氨基二丙酸生育酚磷酸酯盐二钠、月桂酰两性基二乙酸二钠、月桂酰两性基二丙酸二钠、N-月桂酰基天冬氨酸二钠、月桂酰谷氨酸二钠、月桂基苯基醚二磺酸二钠、月桂醇磺基琥珀酸酯二铵、肉豆蔻酰胺MEA-磺基琥珀酸酯二钠、壬基苯酚聚醚-10磺基琥珀酸酯二钠、油酰胺MEA磺基琥珀酸酯二钠、油酰胺MIPA磺基琥珀酸酯二钠、油酰胺PEG-2磺基琥珀酸酯二钠、油酰两性基二丙酸二钠、油醇聚醚-3磺基琥珀酸酯二钠、油醇磷酸酯二钠、油醇磺基琥珀酸酯二钠、棕榈酰胺PEG-2磺基琥珀酸酯二钠、棕榈油酰胺基PEG-2磺基琥珀酸酯二钠、PEG-4椰油酰胺MIPA-磺基琥珀酸酯二钠、PEG-12聚二甲基硅氧烷磺基琥珀酸酯二钠、PEG-8棕榈油脂酸甘油酯类磺基琥珀酸酯二钠、PPG-2-异癸醇聚醚-7羧基两性基二乙酸钠、蓖麻醇酸酰胺MEA磺基琥珀酸酯二钠、谷甾醇聚醚-14磺基琥珀酸酯二钠、大豆油酰两性基二乙酸二钠、硬脂酰胺MEA-磺基琥珀酸酯二钠、硬脂亚氨基二丙酸二钠、硬脂酰两性基二乙酸二钠、硬脂酰谷氨酸二钠、磺基琥珀酸单酰硬脂胺二钠、硬脂醇磺基琥珀酸酯二钠、2-磺基月桂酸二钠、2-磺基棕榈酸二钠、妥尔油酰胺MEA磺基琥珀酸酯二钠、牛脂酰胺MEA磺基琥珀酸酯二钠、牛脂酰两性基二乙酸二钠、牛脂亚氨基双丙酸二钠、磺基琥珀酸单酰牛脂胺二钠、十三醇磺基琥珀酸酯二钠、十一碳烯酰胺MEA磺基琥珀酸酯二钠、十一碳烯酰胺PEG-2磺基琥珀酸酯二钠、十一碳烯酰谷氨酸二钠、单小麦胚油酰MEA磺基琥珀酸酯二钠、单小麦胚油酰胺PEG-2磺基琥珀酸酯二钠、麦胚油酰两性基二乙酸二钠、椰油酰胺二乙酸二-TEA盐、油酰胺基PEG-2磺基琥珀酸酯二-TEA盐、棕榈酰天冬氨酸二-TEA盐、双十三醇磺基琥珀酸酯钠、十二烷基苯磺酸、芥酸酰胺丙基羟基磺基甜菜碱、乙基己醇聚醚-3羧酸、乙基PEG-15椰油胺硫酸酯盐、辛基甘油基醚、己基癸酸、氢化椰油酸、氢化羊毛脂醇聚醚-25、氢化鲱油脂肪酸、氢化棕榈油酸、氢化棕榈仁油胺氧化物、氢化牛脂酸、氢化牛脂基胺氧化物、氢化牛脂基甜菜碱、氢化牛脂醇聚醚-25、氢化牛脂酰谷氨酸、氢化假丝酵母提取物、羟鲸蜡醇聚醚-60、羟乙基乙酰氧基甲基铵PG-聚二甲基硅氧烷、月桂醇聚醚硫酸酯羟乙基丁胺盐、羟乙基羧甲基椰油酰胺基丙胺、羟乙基羟丙基C12-15烷氧基丙胺氧化物、羟月桂基/羟肉豆蔻基甜菜碱、羟基硬脂酸、酰胺基羟基琥珀酰亚胺C10-40异烷酸乙基己酯、酰胺基羟基琥珀酰亚胺C21-22异烷酸乙基己酯、羟基磺基甜菜碱、IPDI/PEG-15大豆油胺氧化物、IPDI/PEG-15大豆油胺乙醇硫酸甲酯共聚物、IPDI/PEG-15大豆油甘氨酸酯共聚物、lsoceteth-30、异月桂醚-4磷酸酯、异聚甘油-3聚二甲基硅氧烷、异聚甘油-3聚二甲基硅氧烷、羊毛脂酸异丙醇胺酯、十二烷基苯磺酸异丙醇胺盐、异硬脂酰胺丙基胺氧化物、异硬脂酰胺丙基甜菜碱、异硬脂酰胺丙基吗啉氧化物、异硬脂醇聚醚-8、异硬脂醇聚醚-16、异硬脂醇聚醚-22、异硬脂醇聚醚-25、异硬脂醇聚醚-50、异硬脂酸、异硬脂酰基水解胶原、霍霍巴油PEG-150酯类、霍霍巴蜡PEG-80酯类、霍霍巴蜡PEG-120酯类、羊毛脂醇聚醚-20、羊毛脂醇聚醚-25、羊毛脂醇聚醚-40、羊毛脂醇聚醚-50、羊毛脂醇聚醚-60、羊毛脂醇聚醚-75、羊毛脂酸、月桂酰胺丙基胺氧化物、月桂酰胺丙基甜菜碱、月桂酰胺丙基羟磺基甜菜碱、月桂基胺氧化物、月桂氨基丙酸、月桂基二甲基羟丙基癸基葡糖苷氯化铵、月桂基二甲基月桂基葡糖苷羟丙基氯化铵、月桂醇聚醚-16、月桂醇聚醚-20、月桂醇聚醚-21、月桂醇聚醚-23、月桂醇聚醚-25、月桂醇聚醚-30、月桂醇聚醚-38、月桂醇聚醚-40、月桂醇聚醚-3羧酸、月桂醇聚醚-4羧酸、月桂醇聚醚-5羧酸、月桂醇聚醚-6羧酸、月桂醇聚醚-8羧酸、月桂醇聚醚-10羧酸、月桂醇聚醚-11羧酸、月桂醇聚醚-12羧酸、月桂醇聚醚-13羧酸、月桂醇聚醚-14羧酸、月桂醇聚醚-17羧酸、月桂醇聚醚-6柠檬酸酯、月桂醇聚醚-7柠檬酸酯、月桂醇聚醚-1磷酸酯、月桂醇聚醚-2磷酸酯、月桂醇聚醚-3磷酸酯、月桂醇聚醚-4磷酸酯、月桂醇聚醚-7磷酸酯、月桂醇聚醚-8磷酸酯、月桂醇聚醚-7酒石酸酯、月桂酸、月桂亚氨基双丙二醇、月桂亚氨基二丙酸、月桂酰两性基二丙酸、月桂酰β-氨基丙酸、月桂酰基胶原氨基酸、月桂酰乙基三甲基铵甲基硫酸酯盐、月桂酰水解胶原、月桂酰水解弹性蛋白、月桂酰甲基葡糖酰胺、月桂酰肌氨酸、月桂酰蚕丝氨基酸、月桂基甜菜碱、月桂基聚二甲基硅氧烷/聚甘油-3交联聚合物、月桂基二甲基羟丙基椰油基葡糖苷氯化铵、月桂基葡糖苷、月桂基葡糖苷羟丙基三甲基氯化铵、月桂甘醇羟丙基醚、月桂基羟基磺基甜菜碱、月桂基苹果酰胺、月桂基甲基萄糖胺、(月桂/肉豆蔻)基二醇羟丙基醚、(月桂/肉豆蔻)基小麦麸/秸苷类、月桂基聚甘油-3聚二甲基硅氧乙基聚二甲基硅氧烷、月桂基吡咯烷酮、月桂基二甲基磺基甜菜碱、亚油酸、亚麻酸、亚麻油酸、赖氨酸椰油酸盐、澳洲坚果籽油甘油聚醚-8酯类、椰油醇聚醚硫酸酯镁、椰油醇硫酸酯镁、异十二烷基苯基磺酸镁、月桂醇聚醚-11羧酸镁、月桂醇聚醚硫酸酯镁、月桂醇聚醚-5硫酸酯镁、月桂醇聚醚-8硫酸酯镁、月桂醇聚醚-16硫酸酯镁、月桂醇聚醚-3磺基琥珀酸酯镁、月桂基羟丙基磺酸镁、月桂醇硫酸酯镁、甲基椰油基牛磺酸镁、肉豆蔻醇聚醚硫酸酯镁、油醇聚醚硫酸酯镁、椰油醇硫酸酯镁/TEA盐、曼尼古根冰河泥、椰油酸MEA盐、月桂醇聚醚-6羧酸MEA、盐桂醇聚醚硫酸酯MEA盐,月桂醇硫酸酯MEA盐、PPG-6-月桂醇聚醚-7羧酸MEA盐、PPG-8-硬脂醇聚醚-7羧酸MEA盐、十一碳烯酸MEA盐、美罗沙波108、美罗沙波174、美罗沙波178、美罗沙波254、美罗沙波255、美罗沙波258、美罗沙波314、甲氧基PEG-450酰胺基戊二酰琥珀酰胺、甲氧基PEG-450酰胺基羟基琥珀酰亚胺琥珀酸酯、甲氧基PEG-450马来酰亚胺、甲基吗啉氧化物、牛奶酰胺丙基胺氧化物、牛奶酰胺丙基甜菜碱、貂油酰胺丙胺氧化物、貂油酰胺丙基甜菜碱、C12-15链烷醇聚醚硫酸酯MIPA盐、十二烷基苯磺酸MIPA盐、月桂醇聚醚硫酸酯MIPA盐、月桂醇硫酸酯MIPA盐、混合异丙醇胺羊毛脂酸盐、混合异丙醇胺月桂基硫酸盐、混合异丙醇胺肉豆蔻酸盐、吗啉油酸盐、吗啉硬脂酸盐、肉豆蔻醇聚醚-3羧酸、肉豆蔻醇聚醚-5羧酸、肉豆蔻基苄基二甲基氯化铵、肉豆蔻酰胺丙基胺氧化物、肉豆蔻酰胺丙基甜菜碱、肉豆蔻酰胺丙基二甲胺磷酸盐、肉豆蔻酰胺丙基羟磺基甜菜碱、肉豆蔻酰胺丙基PG-二甲基氯化铵磷酸酯、肉豆蔻胺氧化物、肉豆蔻氨基丙酸、肉豆蔻酸、肉豆蔻酰乙基三甲基铵甲基硫酸酯盐、肉豆蔻酰基谷氨酸、肉豆蔻酰基水解胶原、肉豆蔻酰肌氨酸、肉豆蔻基甜菜碱、肉豆蔻基/鲸蜡基胺氧化物、肉豆蔻基二甲基羟丙基椰油基葡糖苷氯化铵、肉豆蔻基葡糖苷、肉豆蔻醇磷酸酯、壬基酚聚醚-20、壬基酚聚醚-23、壬基酚聚醚-25、壬基酚聚醚-30、壬基酚聚醚-35、壬基酚聚醚-40、壬基酚聚醚-44、壬基酚聚醚-50、壬基酚聚醚-100、壬基酚聚醚-120、壬基酚聚醚-5羧酸、壬基酚聚醚-8羧酸、壬基酚聚醚-10羧酸、壬基酚聚醚-3磷酸酯、壬基酚聚醚-4磷酸酯、壬基酚聚醚-6磷酸酯、壬基酚聚醚-9磷酸酯、壬基酚聚醚-10磷酸酯、二壬基酚聚醚-30、二壬基酚聚醚-49、二壬基酚聚醚-100、二壬基酚聚醚-150、二壬基酚聚醚-7磷酸酯、二壬基酚聚醚-8磷酸酯、二壬基酚聚醚-9磷酸酯、二壬基酚聚醚-10磷酸酯、二壬基酚聚醚-11磷酸酯、二壬基酚聚醚-15磷酸酯、二壬基酚聚醚-24磷酸酯、燕麦油酰胺丙基甜菜碱、辛苯酚聚醚-16、辛苯酚聚醚-25、辛苯酚聚醚-30、辛苯酚聚醚-33、辛苯酚聚醚-40、辛苯酚聚醚-70、辛苯酚聚醚-20羧酸、辛基十二醇聚醚-20、辛基十二醇聚醚-25、辛基十二醇聚醚-30、油酰胺基丙胺氧化物、油酰胺丙基甜菜碱、油酰胺丙基(羟基磺基)丙基二甲基铵、油胺氧化物、油酸、油酰基水解胶原、油酰肌氨酸、油醇聚醚-20、油醇聚醚-23、油醇聚醚-24、油醇聚醚-25、油醇聚醚-30、油醇聚醚-35、油醇聚醚-40、油醇聚醚-44、油醇聚醚-50、油醇聚醚-3羧酸、油醇聚醚-6羧酸、油醇聚醚-10羧酸、油基甜菜碱、橄榄油酰胺丙胺氧化物、橄榄油酰胺丙基甜菜碱、橄榄油酸、橄榄油酰基水解小麦蛋白、麦冬提取物硬脂酸酯、臭氧化油醇聚醚-10、臭氧化PEG-10油酸酯、臭氧化PEG-14油酸酯、臭氧化聚山梨醇酯80、棕榈油酸、棕榈油酰胺丙基甜菜碱、棕榈油醇聚醚-2磷酸酯、棕榈酰胺丙基胺氧化物、棕榈酰胺丙基甜菜碱、棕榈胺氧化物、棕榈酸、棕榈酰胶原氨基酸类、棕榈酰甘氨酸、棕榈酰水解胶原、棕榈酰水解牛奶蛋白、棕榈酰水解小麦蛋白、棕榈酰角蛋白氨基酸类、棕榈酰寡肽、棕榈酰蚕丝氨基酸类、棕榈仁油酸、棕榈仁油酰胺丙基甜菜碱、桃仁油甘油聚醚-8酯类、花生油酸、PEG-10蓖麻油、PEG-40蓖麻油、PEG-44蓖麻油、PEG-50蓖麻油、PEG-54蓖麻油、PEG-55蓖麻油、PEG-60蓖麻油、PEG-80蓖麻油、PEG-100蓖麻油、PEG-200蓖麻油、PEG-11椰油酰胺、PEG-6椰油酰胺磷酸酯、PEG-4椰油胺、PEG-8椰油胺、PEG-12椰油胺、PEG-150二山嵛酸酯、PEG-90二异硬脂酸酯、PEG-75二月桂酸酯、PEG-150二月桂酸酯、PEG-75二油酸酯、PEG-150二油酸酯、PEG-75二硬脂酸酯、PEG-120二硬脂酸酯、PEG-150二硬脂酸酯、PEG-175二硬脂酸酯、PEG-190二硬脂酸酯、PEG-250二硬脂酸酯、PEG-30甘油椰油酸酯、PEG-40甘油椰油酸酯、PEG-78甘油椰油酸酯、PEG-80甘油椰油酸酯、PEG-30甘油异硬脂酸酯、PEG-40甘油异硬脂酸酯、PEG-50甘油异硬脂酸酯、PEG-60甘油异硬脂酸酯、PEG-90甘油异硬脂酸酯、PEG-23甘油月桂酸酯、PEG-30甘油月桂酸酯、PEG-25甘油油酸酯、PEG-30甘油油酸酯、PEG-30甘油大豆油酸酯、PEG-25甘油硬脂酸酯、PEG-30甘油硬脂酸酯、PEG-40甘油硬脂酸酯、PEG-120甘油硬脂酸酯、PEG-200甘油硬脂酸酯、PEG-28甘油脂牛油酸酯、PEG-80甘油脂牛油酸酯、PEG-82甘油脂牛油酸酯、PEG-130甘油脂牛油酸酯、PEG-200甘油脂牛油酸酯、PEG-45氢化蓖麻油、PEG-50氢化蓖麻油、PEG-54氢化蓖麻油、PEG-55氢化蓖麻油、PEG-60氢化蓖麻油、PEG-80氢化蓖麻油、PEG-100氢化蓖麻油、PEG-200氢化蓖麻油、PEG-30氢化羊毛脂、PEG-70氢化羊毛脂、PEG-50氢化棕榈油酰胺、PEG-2异硬脂酸酯、PEG-3异硬脂酸酯、PEG-4异硬脂酸酯、PEG-6异硬脂酸酯、PEG-8异硬脂酸酯、PEG-10异硬脂酸酯、PEG-12异硬脂酸酯、PEG-20异硬脂酸酯、PEG-30异硬脂酸酯、PEG-40异硬脂酸酯、PEG-26霍霍巴酸、PEG-40霍霍巴酸、PEG-15霍霍巴醇、PEG-26霍霍巴醇、PEG-40霍霍巴醇、PEG-35羊毛脂、PEG-40羊毛脂、PEG-50羊毛脂、PEG-55羊毛脂、PEG-60羊毛脂、PEG-70羊毛脂、PEG-75羊毛脂、PEG-85羊毛脂、PEG-100羊毛脂、PEG-150羊毛脂、PEG-75羊毛脂油、PEG-2月桂酰胺、PEG-3月桂基胺氧化物、PEG-20月桂酸酯、PEG-32月桂酸酯、PEG-75月桂酸酯、PEG-150月桂酸酯、PEG-70芒果籽油甘油酯类、PEG-20一缩甘露醇月桂酸酯、PEG-8甲基醚聚二甲基硅氧烷、PEG-120甲基葡糖二油酸酯、PEG-80甲基葡糖月桂酸酯、PEG-120甲基葡糖三油酸酯、PEG-4褐煤酸酯、PEG-30油胺、PEG-20油酸酯、PEG-23油酸酯、PEG-32油酸酯、PEG-36油酸酯、PEG-75油酸酯、PEG-150油酸酯、PEG-20棕榈酸酯、PEG-150聚甘油-2三硬脂酸酯、PEG/PPG-28/21乙酸酯聚二甲基硅氧烷、PEG/PPG-24/18丁基醚聚二甲基硅氧烷、PEG/PPG-3/17共聚物、PEG/PPG-5/35共聚物、PEG/PPG-8/55共聚物、PEG/PPG-10/30共聚物、PEG/PPG-10/65共聚物、PEG/PPG-12/35共聚物、PEG/PPG-16/17共聚物、PEG/PPG-20/9共聚物、PEG/PPG-20/20共聚物、PEG/PPG-20/60共聚物、PEG/PPG-20/65共聚物、PEG/PPG-22/25共聚物、PEG/PPG-28/30共聚物、PEG/PPG-30-35共聚物、PEG/PPG-30/55共聚物、PEG/PPG-35/40共聚物、PEG/PPG-50/40共聚物、PEG/PPG-150/35共聚物、PEG/PPG-160/30共聚物、PEG/PPG-190/60共聚物、PEG/PPG-200/40共聚物、PEG/PPG-300/55共聚物、PEG/PPG-20/22甲基醚聚二甲基硅氧烷、PEG-26-PPG-30磷酸酯、PEG/PPG-4/2丙基庚醚、PEG/PPG-6/2丙基庚醚、PEG-7/PPG-2丙基庚醚、PEG/PPG-8/2丙基庚醚、PEG/PPG-10/2丙基庚醚、PEG/PPG-14/2丙基庚醚、PEG/PPG-40/2丙基庚醚、PEG/PPG-10/2蓖麻醇酸酯、PEG/PPG-32/3蓖麻醇酸酯、PEG-55丙二醇油酸酯、PEG-25丙二醇硬脂酸酯、PEG-75丙二醇硬脂酸酯、PEG-120丙二醇硬脂酸酯、PEG-5油菜籽甾醇、PEG-10油菜籽甾醇、PEG-40蓖麻油酰胺、PEG-75牛油树脂甘油酯类、PEG-75娑罗双树脂甘油酯类、PEG-20失水山梨醇椰油酸酯、PEG-20失水山梨醇异硬脂酸酯、PEG-40失水山梨醇羊毛脂酸酯、PEG-75失水山梨醇羊毛脂酸酯、PEG-10失水山梨醇月桂酸酯、PEG-40失水山梨醇月桂酸酯、PEG-44失水山梨醇月桂酸酯、PEG-75失水山梨醇月桂酸酯、PEG-80失水山梨醇月桂酸酯、PEG-20失水山梨醇油酸酯、PEG-80失水山梨醇棕榈酸酯、PEG-40山梨坦硬脂酸酯、PEG-60山梨坦硬脂酸酯、PEG-160失水山梨醇三异硬脂酸酯、PEG-40大豆甾醇、PEG-2硬脂酰胺羧酸、PEG-9硬脂酰胺羧酸、PEG-20硬脂酸酯、PEG-23硬脂酸酯、PEG-25硬脂酸酯、PEG-30硬脂酸酯、PEG-32硬脂酸酯、PEG-35硬脂酸酯、PEG-36硬脂酸酯、PEG-40硬脂酸酯、PEG-45硬脂酸酯、PEG-50硬脂酸酯、PEG-55硬脂酸酯、PEG-75硬脂酸酯、PEG-90硬脂酸酯、PEG-100硬脂酸酯、PEG-120硬脂酸酯、PEG-150硬脂酸酯、PEG-45硬脂酸酯磷酸酯、PEG-20妥尔酸酯、PEG-50牛脂酰胺、PEG-2牛脂酰胺DEA、PEG-20牛脂酸酯、PEG-66三羟硬脂精、PEG-200三羟硬脂精、PEG-60山茶油酸酯甘油酯类、壬酸、十五烷基苯酚聚醚-200、苯酚聚醚-6磷酸酯、泊洛沙姆105、泊洛沙姆108、泊洛沙姆182、泊洛沙姆183、泊洛沙姆184、泊洛沙姆188、泊洛沙姆217、泊洛沙姆234、泊洛沙姆235、泊洛沙姆237、泊洛沙姆238、泊洛沙姆288、泊洛沙姆334、泊洛沙姆335、泊洛沙姆338、泊洛沙胺908、泊洛沙胺1508,聚二甲基硅氧PEG/PPG-24/19丁基醚硅倍半氧烷、聚二甲基硅氧PPG-13丁基醚硅倍半氧烷、聚甘油-6癸酸酯、聚甘油-10二月桂酸酯、聚甘油-20七辛酸酯、聚甘油-20六辛酸酯、聚甘油-2月桂醚、聚甘油-10月桂醚、Polyglyceryl-20Octaisononanoate、聚甘油-6五辛酸酯、聚甘油-10五辛酸酯、月桂基聚甘油-3聚二甲基硅氧乙基聚二甲基硅氧烷、聚甘油-6四辛酸酯、聚甘油-10四月桂酸酯、聚甘油-6三辛酸酯、聚甘油-10三月桂酸酯、聚季铵盐-77、聚季铵盐-78、聚季铵盐-79、聚季铵盐-80、聚季铵盐-81、聚季铵盐-82、库氏安匝木(POMADERRIS KUMERAHOU)花/叶提取物、茯苓(PORIA COCOS)提取物、枞酰水解胶原钾、巴巴苏油酸钾、山嵛酸钾、C9-15醇磷酸酯钾、C11-15醇磷酸酯钾、C12-13醇磷酸酯钾、C12-14醇磷酸酯钾、癸酸钾、辛酰谷氨酸二钾、辛酰基水解大米蛋白钾、蓖麻油酸钾、椰油酸钾、椰油酰谷氨酸钾、椰油酰甘氨酸钾、椰油酰水解酪蛋白钾、椰油酰水解胶原钾、椰油酰水解玉米蛋白钾、椰油酰水解角蛋白钾、椰油酰水解燕麦蛋白钾、椰油酰水解马铃薯蛋白钾、椰油酰水解米糠蛋白钾、椰油酰水解大米蛋白钾、椰油酰水解蚕丝钾、椰油酰水解大豆蛋白钾、椰油酰水解小麦蛋白钾、椰油酰水解酵母蛋白钾、椰油酰PCA钾、椰油酰肌氨酸钾、椰油酰牛磺酸钾、玉米油酸钾、环羧丙基油酸钾、二羟乙基椰油胺氧化物磷酸酯钾、聚二甲基硅氧烷PEG-7磷酸酯钾、十二烷基苯磺酸钾、大麻籽油酸钾、氢化椰油酸钾、氢化棕榈油酸钾、氢化牛脂酸钾、羟基硬脂酸钾、羟基硬脂酸钾、羊毛脂酸钾、月桂酸钾、月桂醇聚醚-3羧酸钾、月桂醇聚醚-4羧酸钾、月桂醇聚醚-5羧酸钾、月桂醇聚醚-6羧酸钾、月桂醇聚醚-10羧酸钾、月桂醇聚醚磷酸钾、月桂酰胶原氨基酸钾、月桂酰谷氨酸钾、月桂酰水解胶原钾、月桂酰水解豌豆蛋白钾、月桂酰水解大豆蛋白钾、月桂酰PCA钾、月桂酰豌豆氨基酸钾、月桂酰肌氨酸钾、月桂酰蚕丝氨基酸钾、月桂酰小麦氨基酸钾、月桂醇磷酸酯钾、月桂醇硫酸酯钾、亚油酸钾、偏磷酸钾、甲基椰油酰基牛磺酸钾、肉豆蔻酸钾、肉豆蔻酰谷氨酸钾、肉豆蔻酰水解胶原钾、辛基酚聚醚-12磷酸酯钾、油酸钾、油酰水解胶原钾、橄榄油酸钾、橄榄油酰水解燕麦蛋白钾、橄榄油酰水解小麦蛋白钾、橄榄油酰/月桂酰小麦氨基酸钾、橄榄油酰PCA钾、棕榈油酸钾、棕榈酸钾、棕榈酰水解玉米蛋白钾、棕榈酰水解燕麦蛋白钾、棕榈酰水解大米蛋白钾、棕榈酰水解甜杏仁蛋白钾、棕榈酰水解小麦蛋白钾、棕榈仁油酸钾、花生油酸钾、油菜籽油酸钾、蓖麻醇酸钾、红花油酸钾、大豆油酸钾、硬脂酸钾、硬脂酰水解胶原钾、妥尔油酸钾、牛脂酸钾、牛磺酸钾、牛磺酸钾月桂酸盐、十三醇聚醚-3羧酸钾、十三醇聚醚-4羧酸钾、十三醇聚醚-7羧酸钾、十三醇聚醚-15羧酸钾、十三醇聚醚-19羧酸钾、十三醇聚醚-6磷酸钾、十三醇聚醚-7磷酸钾、山茶油酸钾、十一烯酸钾、十一碳烯酰基水解胶原钾、十一碳烯酰水解大米蛋白钾、PPG-30-丁醇聚醚-30、PPG-36-丁醇聚醚-36、PPG-38-丁醇聚醚-37、PPG-30-辛醇聚醚-4磷酸酯、PPG-10鲸蜡基醚磷酸酯、PPG-2C9-11醇聚醚-8、PPG-1-癸醇聚醚-5、PPG-3-癸醇聚醚-2羧酸、PPG-30-乙基己醇聚醚-4磷酸酯、PPG-20-甘油聚醚-30、PPG-2羟乙基椰油/异硬脂酰胺、PPG-2-异癸醇聚醚-8、PPG-2-异癸醇聚醚-10、PPG-2-异癸醇聚醚-18、PPG-2-癸醇聚醚-25、PPG-4-癸醇聚醚-10、丙基三甲基铵水解胶原、季铵盐-24、季铵盐-52、季铵盐-87、油菜籽油酸、米糠酸、稻米油甘油聚醚-8酯类、蓖麻醇酸酰胺丙基甜菜碱、蓖麻醇酸、蓖麻油醇聚醚-40、红花油酸、Sapindus Oahuensis水果提取物、肥皂草(SAPONARIA OFFICINALIS)根粉、皂苷、钾皂、钠/钾皂、皂基、钾皂基、芝麻油甘油聚醚-8酯类、芝麻油酰胺丙基胺氧化物、芝麻酰胺丙基甜菜碱、牛油树脂酰胺丙基甜菜碱、牛油树脂甘油聚醚-8酯类、花生酸钠、Sodium Arga-nampohoacetate、木鲁星果棕油酸钠、鳄梨油酸钠、巴巴苏油酰基两性基乙酸钠、巴巴苏油酸钠、巴巴苏油硫酸酯钠、山嵛酸钠、双甘醇蓖麻醇酸基磺基琥珀酸酯钠、双羟乙基甘氨酸钠椰油基葡糖苷交联共聚物、双羟乙基甘氨酸钠月桂基葡糖苷交联共聚物、玻璃苣油酰胺丙基PG-二甲基氯化铵磷酸酯钠、丁基苯酚聚醚-12硫酸酯钠、丁基葡萄糖苷羟丙基磷酸钠、C13-17烷磺酸钠、C14-18烷磺酸钠、C12-15烷氧丙基亚氨基二丙酸钠、C10-16醇硫酸酯钠、C11-15烷基硫酸钠、C12-13烷基硫酸钠、C12-15烷基硫酸钠、C12-18烷基硫酸钠、C16-20烷基硫酸钠、C9-22仲烷基磺酸钠、C14-17仲烷基磺酸钠、癸酸钠、癸酰两性基乙酸钠、癸酰两性基羟丙基磺酸钠、癸酰两性基丙酸钠、癸酰甲基牛磺酸钠、辛酸钠、辛醇聚醚-2羧酸钠、辛醇聚醚-9羧酸钠、辛酰两性基乙酸钠、辛酰两性基羟丙基磺酸钠、辛酰两性基丙酸钠、辛酰谷氨酸二钠、辛酰水解小麦蛋白钠、辛基PG-磺酸钠、辛基磺酸钠、蓖麻油酸钠、鲸蜡硬脂醇聚醚-13羧酸钠、鲸蜡硬脂醇硫酸酯钠、鲸蜡醇聚醚-13羧酸钠、鲸蜡醇硫酸酯钠、椰油酰胺丙基PG-二甲基氯化铵磷酸酯钠、椰油基氨基丙酸钠、椰油醇聚醚硫酸酯钠、椰油醇聚醚-30硫酸酯钠、可可脂酰两性基乙酸钠、可可脂酸酯钠、椰油酰两性基乙酸钠、椰油酰两性基羟丙基磺酸钠、椰油酰两性基丙酸钠、椰油酸钠、椰油醇/巴巴苏油醇/安迪拉巴醇硫酸酯钠、椰油醇/巴巴苏油醇硫酸酯钠、椰油基葡糖苷羟丙基磷酸钠、椰油基葡糖苷羟丙基磺酸钠、椰油基-葡糖苷酒石酸酯钠、椰油醇甘油醚磺酸钠、椰油醇/氢化牛脂醇硫酸酯钠、椰油基亚氨基二乙酸钠、椰油酸单甘油酯硫酸酯钠、椰油酸单甘油酯磺酸酯钠、椰油脂基PG-二甲基氯化铵磷酸酯钠、椰油醇硫酸酯钠、椰油醇磺基乙酸酯钠、椰油酰氨基丙酸钠、椰油酰基氨基酸钠、椰油酰胶原氨基酸钠、椰油酰谷氨酸二钠、椰油酰谷氨酸钠、椰油酰甘氨酸钠、椰油酰/氢化牛脂谷氨酸钠、椰油酰解胶原钠、椰油酰水解角蛋白钠、椰油酰水解大米蛋白钠、椰油酰水解蚕丝钠、椰油酰水解大豆蛋白钠、椰油酰水解甜扁桃蛋白钠、椰油酰水解小麦蛋白谷氨酸钠、椰油酰水解小麦蛋白谷氨酸钠、椰油酰羟乙磺酸酯钠、椰油酰甲氨基丙酸钠、椰油酰燕麦氨基酸钠、Sodium椰油酰基/棕榈油酰基/Sunfloweroyl谷氨酸钠、椰油酰脯氨酸钠、椰油酰肌氨酸钠、椰油酰牛磺酸钠、椰油酰苏氨酸钠、椰油酰小麦氨基酸钠、C12-14烯烃磺酸钠、C14-16烯烃磺酸钠、C14-18烯烃磺酸钠、C16-18烯烃磺酸钠、玉米油酰两性基丙酸钠、棉花籽油酰基两性基乙酸钠、C13-15烷醇聚醚-8丁醇磷酸酯钠、C9-11烷醇聚醚-6羧酸钠、C11-15烷醇聚醚-7羧酸钠、C12-13烷醇聚醚-5羧酸钠、C12-13烷醇聚醚-8羧酸钠、C12-13烷醇聚醚-12羧酸钠、C12-15烷醇聚醚-6羧酸钠、C12-15烷醇聚醚-7羧酸钠、C12-15烷醇聚醚-8羧酸钠、C14-15烷醇聚醚-8羧酸钠、C12-14仲烷醇聚醚-8羧酸钠、C14-15烷醇聚醚-PG磺酸钠、C12-13烷醇聚醚-2磷酸钠、C13-15烷醇聚醚-8磷酸钠、C9-15烷醇聚醚-3硫酸钠、C10-15烷醇聚醚硫酸钠、C10-16烷醇聚醚-2硫酸钠、C12-13烷醇聚醚硫酸钠、C12-15烷醇聚醚硫酸钠、C12-15烷醇聚醚-3硫酸钠、C13-15烷醇聚醚-3硫酸钠、C12-14仲烷醇聚醚-3硫酸钠、C12-15烷醇聚醚-3磺酸钠、C12-15烷醇聚醚-7磺酸钠、C12-15烷醇聚醚-15磺酸钠、癸醇聚醚-2羧酸钠、癸醇聚醚硫酸酯钠、癸基苯磺酸钠、癸基葡萄糖苷羟丙基磷酸钠、癸基葡萄糖苷羟丙基磺酸钠、二(月桂醇聚醚-7)柠檬酸酯钠、二(月桂醇聚醚-10)磷酸酯钠、二亚油酰胺丙基PG-二甲基氯化铵磷酸酯钠、二聚亚油酸钠、二(油醇聚醚-8)磷酸酯钠、十二烷基苯磺酸钠、2-磺基月桂酸乙酯钠、甘油油酸酯磷酸酯钠、葡萄籽油酰胺丙基PG-二甲基氯化铵磷酸酯钠、葡萄籽油酰基两性基乙酸钠、葡萄籽油酸钠、大麻籽油酰两性基乙酸钠、己醇聚醚-4羧酸钠、氢化椰油酸钠、氢化椰油酰基甲基羟乙基磺酸钠、氢化棕榈油酸钠、氢化牛脂酸钠、氢化牛脂酰谷氨酸钠、羟月桂基二甲基铵乙基磷酸钠、棕榈仁油酸羟丙酯磺酸钠、磷酸羟丙酯癸基葡糖苷交联聚合物钠、磷酸羟丙酯月桂基葡糖苷交联聚合物钠、磺酸羟丙酯椰油基葡糖苷交联聚合物钠、磺酸羟丙酯癸基葡糖苷交联聚合物钠、磺酸羟丙酯月桂基葡糖苷交联聚合物钠、羟基硬脂酸钠、异硬脂酸钠、异硬脂醇聚醚-6羧酸钠、异硬脂醇聚醚-11羧酸钠、异硬脂酰两性基乙酸钠、异硬脂酰两性基丙酸钠、N-异硬脂酰甲基牛磺酸钠、羊毛脂醇聚醚硫酸酯钠、羊毛脂酸钠、猪油酸钠、月桂酰胺基二乙酸钠、月桂氨基丙酸钠、月桂酸钠、月桂醇聚醚-3羧酸钠、月桂醇聚醚-4羧酸钠、月桂醇聚醚-5羧酸钠、月桂醇聚醚-6羧酸钠、月桂醇聚醚-8羧酸钠、月桂醇聚醚-11羧酸钠、月桂醇聚醚-12羧酸钠、月桂醇聚醚-13羧酸钠、月桂醇聚醚-14羧酸钠、月桂醇聚醚-16羧酸钠、月桂醇聚醚-17羧酸钠、月桂醇聚醚硫酸酯钠、月桂醇聚醚-5硫酸酯钠、月桂醇聚醚-7硫酸酯钠、月桂醇聚醚-8硫酸酯钠、月桂醇聚醚-12硫酸酯钠、月桂醇聚醚-40硫酸酯钠,月桂醇聚醚-7酒石酸酯钠,月桂亚氨基二丙酸二钠、月桂亚氨基二丙酸二钠,月桂酰两性基羟丙基磺酸钠、月桂酰两性基PG-乙酸盐磷酸酯钠、月桂酰两性基丙酸钠、月桂酰天冬氨酸钠、月桂酰胶原氨基酸钠、月桂酰甘氨酸丙酸钠、月桂酰水解胶原钠、月桂酰水解蚕丝钠、月桂酰羟丙基磺酸钠、月桂酰羟乙磺酸钠、月桂酰基甲基氨基丙酸钠、月桂酰甲基羟乙基磺酸钠、月桂酰Millet氨基酸钠、月桂酰/肉豆蔻酰天冬氨酸钠、月桂酰燕麦氨基酸钠、月桂酰肌氨酸钠、月桂酰蚕丝氨基酸钠、月桂酰牛磺酸钠、月桂酰小麦氨基酸钠、月桂基二(亚乙基二氨基)氨基乙酸钠、月桂基葡萄糖羧酸钠、月桂基葡糖苷羟丙基磷酸钠、月桂基葡糖苷羟丙基磺酸钠、月桂基甘醇羧酸钠、月桂基羟乙酰胺硫酸酯钠、月桂醇磷酸酯二钠、月桂醇硫酸酯钠、月桂醇磺基乙酸酯钠、亚油酸钠、澳洲坚果籽油酸钠、芒果油酰两性基乙酸钠、芒果籽油酯钠盐、月桂醇聚醚-2磺基琥珀酸酯钠/MEA、甲氧基PPG-2乙酸钠、甲基椰油酰基牛磺酸钠、甲基月桂酰基牛磺酸钠、甲基肉豆蔻酰基牛磺酸钠、甲基油酰基牛磺酸钠、甲基棕榈酰基牛磺酸钠、甲基硬脂酰基牛磺酸钠、2-磺基月桂酸甲酯钠、2-磺基棕榈酸甲酯钠、异棕榈酰甲基牛磺酸钠、甲基牛磺酸椰油酰甲基牛磺酸酯钠、肉豆蔻醇聚醚硫酸钠、肉豆蔻酸钠、肉豆蔻酰两性基乙酸钠、肉豆蔻酰谷氨酸钠、肉豆蔻酰水解胶原钠、肉豆蔻酰羟乙磺酸钠、肉豆蔻酰肌氨酸钠、肉豆蔻醇硫酸酯钠、壬苯酚聚醚-6磷酸酯钠、壬苯酚聚醚-9磷酸酯钠、壬苯酚聚醚-1硫酸酯钠、壬苯酚聚醚-3硫酸酯钠、壬基酚聚醚-4硫酸酯钠、壬苯酚聚醚-6硫酸酯钠、壬苯酚聚醚-8硫酸酯钠、壬苯酚聚醚-10硫酸酯钠、壬苯酚聚醚-25硫酸酯钠、辛苯酚聚醚-2乙磺酸酯钠、辛苯酚聚醚-2硫酸酯钠、辛苯酚聚醚-6硫酸酯钠、辛苯酚聚醚-9硫酸酯钠、油酸钠、油酰两性基乙酸钠、油酰两性基羟丙基磺酸钠、油酰两性基丙酸钠、油酰水解胶原钠、油酰羟乙磺酸钠、油醇聚醚硫酸酯钠、油酰基甲基羟乙磺酸钠、油醇硫酸酯钠、橄榄油酰两性基乙酸钠、橄榄油酸钠、橄榄油酰谷氨酸钠、棕榈油酰两性基乙酸钠、棕榈油酸钠、棕榈油酸甘油酯磺酸钠、棕榈酸钠、棕榈酰水解胶原钠、棕榈酰水解小麦蛋白钠、棕榈酰肌氨酸钠、棕榈仁油酸钠、棕榈油酰羟乙磺酸钠、棕榈油酰谷氨酸钠、西番莲籽油酸钠、花生油酰两性基乙酸钠、花生油酸钠、PEG-6椰油酰胺羧酸钠、PEG-8椰油酰胺羧酸钠、PEG-4椰油酰胺硫酸酯钠、PEG-3月桂酰胺羧酸钠、PEG-4月桂酰胺羧酸钠、PEG-8棕榈油甘油酯类羧酸钠、季戊四醇羟丙基亚氨基二乙酸钠树形聚合物、丙氧基PPG-2乙酸钠、油菜籽油酸钠、米糠油酰两性基乙酸钠、蓖麻醇酸钠、蓖麻醇酸酰两性基乙酸钠、Sodium RoseHipsamphoacetate、松脂酸钠、红花油酸钠、Saffloweroyl水解大豆蛋白钠、芝麻籽油酸钠、芝麻油酰两性基乙酸钠、牛油树脂酰两性基乙酸钠、大豆油酸钠、大豆油酰水解胶原钠、硬酯酸钠、硬脂酰两性基乙酸钠、硬脂酰两性基羟丙基磺酸钠、硬脂酰两性基丙酸钠、硬脂酰酪蛋白钠、硬脂酰谷氨酸钠、硬脂酰透明质酸钠、硬脂酰水解胶原钠、硬脂酰水解玉米蛋白钠、硬脂酰水解蚕丝钠、硬脂酰水解大豆蛋白钠、硬脂酰水解小麦蛋白钠、硬脂酰乳清蛋白钠、硬脂酰甲基羟乙磺酸钠、硬脂酰燕麦蛋白钠、硬脂酰豌豆蛋白钠、硬脂酰大豆蛋白钠、硬脂基二甲基甘氨酸钠、硬脂醇硫酸酯钠、葵花籽油酰基两性基乙酸钠、枯草菌脂肽钠、甜扁桃油酰基两性基乙酸钠、甜杏仁油酸钠、妥尔油酰两性基丙酸钠、妥尔油酸钠、牛脂酰两性基乙酸钠、牛脂酸钠、牛脂醇硫酸酯钠、胡桐(CALLOPHYLLUM INOPHYLLUM)籽油酸钠、牛磺酸钠、椰油酰甲基牛磺酸牛磺酸钠、月桂酸牛磺酸钠、月桂酰胶原氨基酸钠/TEA盐、月桂酰水解胶原钠/TEA盐、月桂酰水解角蛋白盐钠/TEA盐、月桂酰基角蛋白氨基酸钠/TEA盐、十一碳烯酰胶原氨基酸钠/TEA盐、十一碳烯酰水解胶原钠/TEA盐、十一碳烯酰水解玉米蛋白钠/TEA盐、十一碳烯酰水解大豆蛋白钠/TEA盐、十一碳烯酰水解小麦蛋白钠/TEA盐、大花可可树(THEOBROMA GRANDIFLORUM)籽油酸钠、十三烷醇聚醚-3羧酸钠、十三烷醇聚醚-4羧酸钠、十三烷醇聚醚-6羧酸钠、十三烷醇聚醚-7羧酸钠、十三烷醇聚醚-8羧酸钠、十三烷醇聚醚-12羧酸钠、十三烷醇聚醚-15羧酸钠、十三烷醇聚醚-19羧酸钠、十三烷醇聚醚硫酸钠、十三烷基苯磺酸钠、十三烷醇硫酸酯钠、三羟甲基丙烷羟丙基亚氨基二乙酸钠树形聚合物、十一烷醇聚醚-5羧酸钠、十一碳烯酸钠、十一碳烯酰两性基乙酸钠、十一碳烯酰两性基丙酸钠、十一碳烯酰谷氨酸二钠、小麦胚油酰两性基乙酸钠、山梨醇聚醚-160三硬脂酸酯、大豆油酸、大豆油酰胺基丙胺氧化物、大豆油酰胺丙基甜菜碱、大豆油甘油聚醚-8酯类、异硬脂酰胺基丙胺氧化物、硬脂酰胺丙基甜菜碱、硬脂胺氧化物、硬脂醇聚醚-15、硬脂醇聚醚-16、硬脂醇聚醚-20、硬脂醇聚醚-21、硬脂醇聚醚-25、硬脂醇聚醚-27、硬脂醇聚醚-30、硬脂醇聚醚-40、硬脂醇聚醚-50、硬脂醇聚醚-80、硬脂醇聚醚-100、硬脂醇聚醚-2磷酸酯、硬脂醇聚醚-3磷酸酯、硬脂酸、硬脂氧丙基三甲基氯化铵、硬脂酰谷氨酸、硬脂酰肌氨酸、硬脂基甜菜碱、硬脂基二甲基丁基葡糖苷羟丙基氯化铵、硬脂基二甲基癸基葡糖苷羟丙基氯化铵、硬脂基二甲基月桂基葡糖苷羟丙基氯化铵、硫酸化蓖麻油、硫酸化椰油、硫酸化甘油油酸酯、硫酸化橄榄油、硫酸化花生油、葵花油酰胺MEA、葵花籽油酸、葵花籽油酰胺丙基羟乙基二甲基氯化铵、葵花籽油甘油聚醚-8酯类、妥尔油酸、牛脂酸、牛脂酰胺基丙基胺氧化物、牛脂酰胺基丙基甜菜碱、牛脂酰胺基丙基羟基磺基甜菜碱、牛脂基胺氧化物、牛脂基甜菜碱、牛脂基二羟乙基甜菜碱、牛脂酰乙基葡糖苷、枞酰水解胶原TEA盐、C12-14醇磷酸酯TEA盐、C10-15烷基硫酸TEA盐、C11-15醇硫酸酯TEA盐、C12-13烷基硫酸TEA盐、TEA-C12-14烷基硫酸TEA盐、TEA-C12-15烷基硫酸TEA盐、TEA C14-17仲烷基磺酸TEA盐、低芥酸菜子油酸TEA盐、椰油酰胺二乙酸TEA盐、椰油酸TEA盐、椰油醇硫酸酯TEA盐、椰油酰基丙氨酸TEA盐、椰油酰基谷氨酸TEA盐、椰油酰基谷氨酰胺TEA盐、椰油酰基甘氨酸TEA盐、椰油酰基水解胶原TEA盐、椰油酰基水解大豆蛋白TEA盐、椰油酰基肌氨酸TEA盐、聚二甲基硅氧烷PEG-7磷酸TEA盐、十二烷基苯磺酸TEA盐、氢化椰油酸TEA盐、氢化牛脂酰谷氨酸TEA盐、异硬脂酸TEA盐、TEA-异硬脂酰基水解胶原TEA盐、月桂氨基丙酸TEA盐、月桂酸TEA盐、月桂酸/肉豆蔻酸TEA盐、月桂醇聚醚硫酸酯TEA盐、月桂酰基胶原氨基酸TEA盐、月桂酰谷氨酸TEA盐、月桂酰水解胶原TEA盐、月桂酰基角蛋白氨基酸TEA盐、月桂酰基甲氨基丙酸TEA盐、月桂酰基/肉豆蔻酰基天冬氨酸TEA盐、月桂酰基肌氨酸TEA盐、月桂醇磷酸酯TEA盐、月桂醇硫酸酯TEA盐、肉豆蔻氨基丙酸TEA盐、肉豆蔻酸TEA盐、肉豆蔻酰基水解胶原TEA盐、油酸TEA盐、油酰基水解胶原TEA盐、油酰基肌氨酸TEA盐、油醇硫酸酯TEA盐、棕榈酸TEA盐、棕榈仁肌氨酸TEA盐、PEG-3椰油酰胺硫酸酯TEA盐、松脂酸TEA盐、硬脂酸TEA盐、妥尔酸TEA盐、十三烷基苯磺酸TEA盐、十一碳烯酸TEA盐、十一碳烯酰水解胶原TEA盐、四甲基癸炔二醇、二羧乙基硬脂基磺基琥珀酰胺酸四钠、月桂醇聚醚硫酸酯TIPA盐、月桂醇硫酸酯TIPA盐、肉豆蔻酸TIPA盐、硬脂酸TIPA盐、生育酚磷酸酯、海藻糖十一烯酸酯、TM-C12-15链烷醇聚醚-2磷酸酯、TM-C12-15链烷醇聚醚-6磷酸酯、TM-C12-15链烷醇聚醚-8磷酸酯、TM-C12-15链烷醇聚醚-10磷酸酯、十三醇聚醚-20、十三醇聚醚-50、十三醇聚醚-3羧酸、十三醇聚醚-4羧酸、十三醇聚醚-7羧酸、十三醇聚醚-8羧酸、十三醇聚醚-15羧酸、十三醇聚醚-19羧酸、十三醇聚醚-10磷酸酯、十三烷基苯磺酸、三(月桂醇聚醚-9)柠檬酸酯、三羟甲基丙烷羟丙基双羟乙胺树形聚合物、三(月桂酰两性基PG-乙酸钠氯化物)磷酸酯、十一烷酸、十一烷醇聚醚-5羧酸、十一碳烯酰胺丙基胺氧化物、十一碳烯酰胺丙基甜菜碱、十一烯酸、十一烯酰胶原氨基酸、十一碳烯酰甘氨酸、十一碳烯酰基水解胶原、十一碳烯酰基小麦氨基酸类、十一烷基葡糖苷、小麦胚芽油脂酸、小麦胚芽油酰胺丙基胺氧化物、小麦胚芽油酰胺丙基甜菜碱、西地格丝兰(YUCCA SCHIDIGERA)叶/根/茎提取物、西地格丝兰(YUCCA SCHIDIGERA)茎提取物、椰油醇聚醚硫酸酯锌和椰油醇硫酸酯锌。
优选的选自组包括月桂醇聚醚硫酸酯钠、椰油酰胺丙基甜菜碱、椰油酰两性基乙酸钠、椰油基葡糖苷和月桂醇磺基琥珀酸酯铵的一种或更多种化合物。
表面活性剂在制剂中的百分比含量可以为0.1至10重量%,并且优选为0.5至5重量%,基于制剂计。
油体
适当的油体,其为O/W乳液的成分,是例如基于含有6至18个,优选8至10个碳原子的Guerbet醇,直链C6-C22-脂肪酸与直链或支链C6-C22-脂肪族醇的酯或支链C6-C13-羧酸与直链或支链C6-C22-脂肪族醇的酯,如例如肉豆蔻酸十四烷酯、棕榈酸十四烷酯、硬脂酸十四烷酯、异硬脂酸十四烷酯、油酸十四烷酯、山嵛酸十四烷酯、芥酸十四烷酯、肉豆蔻酸十六烷酯、棕榈酸十六烷酯、硬脂酸十六烷酯、异硬脂酸十六烷酯、油酸十六烷酯、山嵛酸十六烷酯、芥酸十六烷酯、肉豆蔻酸十八烷酯、棕榈酸十八烷酯、硬脂酸十八烷酯、异硬脂酸十八烷酯、油酸十八烷酯、山嵛酸十八烷酯、芥酸十八烷酯、肉豆蔻酸异十八烷酯、棕榈酸异十八烷酯、硬脂酸异十八烷酯、异硬脂酸异十八烷酯、油酸异十八烷酯、山嵛酸异十八烷酯、油酸异十八烷酯、油醇肉豆蔻酸酯、棕榈酸油醇酯、油醇硬脂酸酯、油醇异硬脂酸酯、油酸油醇酯、山嵛酸油醇酯、芥酸油醇酯、肉豆蔻酸二十二烷酯、棕榈酸二十二烷酯、硬脂酸二十二烷酯、异硬脂酸二十二烷酯、油酸二十二烷酯、山嵛酸二十二烷酯、芥酸二十二烷酯、肉豆蔻酸芥醇酯、棕榈酸芥醇酯、硬脂酸芥醇酯、异硬脂酸芥醇酯、油酸芥醇酯、山嵛酸芥醇酯和芥酸芥醇酯。此外适当的是直链C6-C22-脂肪酸与支链醇,特别是2-乙基己醇的酯、C18-C38-烷基羟基羧酸与直链或支链C6-C22-脂肪族醇的酯,特别是苹果酸二辛酯、直链和/或支链脂肪酸与多元醇(如例如丙二醇、二聚二元醇(Dimerdiol)或三聚三元醇(Trimertriol))和/或Guerbet醇的酯、基于C6-C10-脂肪酸的甘油三酯、基于C6-C18-脂肪酸的液态单-/二-/三酸甘油酯混合物、C6-C22-脂肪族醇和/或Guerbet醇与芳族羧酸,特别是苯甲酸的酯、C2-C12-二羧酸与具有1至22个碳原子的直链或支链醇或者具有2至10个碳原子和2至6个羟基的多元醇的酯、植物油、支链伯醇、取代环己烷、直链和支链C6-C22-脂肪族醇的碳酸酯,如例如碳酸二辛酯(CC)、基于具有6至18个优选8至10个碳原子的脂肪族醇的Guerbet碳酸酯、苯甲酸与直链和/或支链C6-C22-醇的酯(例如TN)、每个烷基具有6至22个碳原子的直链或支链、对称或非对称的二烷基醚,如例如二辛酰基醚(OE)、环氧化脂肪酸酯与多元醇的开环产物、硅油(环聚二甲基硅氧烷、硅酮甲基硅油等级等)和/或脂肪烃或环烷烃,如例如角鲨烷、角鲨烯或二烷基环己烷。
乳化剂
其他非离子或阳离子表面活性剂也可以作为乳化剂添加到制剂中,包括例如:
·2至30摩尔环氧乙烷和/或0至5摩尔环氧丙烷与直链C8-22脂肪族醇、与C12-22脂肪酸、与烷基中具有8-15个碳原子的烷基苯酚的加成产物;
·1至30摩尔环氧乙烷在甘油上的加成产物的C12/18脂肪酸单酯和二酯;
·含有6至22个碳原子的饱和和不饱和脂肪酸甘油单酯和二酯和脱水山梨糖醇单酯和二酯和它们的环氧乙烷加成产物;
·15至60摩尔环氧乙烷与蓖麻油和/或氢化蓖麻油的加成产物;
·多元醇酯,尤其是聚甘油酯例如,聚甘油聚蓖麻醇酸酯、聚甘油聚-12-羟基硬脂酸酯或聚甘油二聚合油异硬脂酸酯。同样适用的是多个这类化合物的混合物;
·2至15摩尔环氧乙烷与蓖麻油和/或氢化蓖麻油的加成产物;
·基于直链、支链、不饱和或饱和C6/22脂肪酸、蓖麻油酸以及12-羟基硬脂酸和甘油、聚甘油、季戊四醇、二季戊四醇、糖醇(例如山梨糖醇)、烷基葡糖苷(例如:甲基葡糖苷、丁基葡糖苷、月桂基葡糖苷)以及多葡糖苷(例如纤维素)的偏酯;
·磷酸单-、二-和三烷酯类以及磷酸单-、二-和/或三-PEG烷酯类及其盐;
·羊毛蜡醇类;
·聚硅氧烷/聚烷基聚醚共聚物及相应衍生物;
·季戊四醇、脂肪酸、柠檬酸和脂肪族醇的混合脂和/或C6-22脂肪酸、甲基葡萄糖和多元醇,优选丙三醇或聚甘油的混合脂;
·烷基和/或烯基低聚糖苷;
·聚二醇类以及
·碳酸甘油酯。
环氧乙烷和/或环氧丙烷与脂肪族醇、脂肪酸和烷基酚的加成产物,脂肪酸或蓖麻油的甘油单酯和二酯和脱水山梨糖醇单酯和二酯是市场上可以买到的产品。在这里是指同系混合物,其平均烷氧基化度相当于进行加成反应的环氧乙烷和/或环氧丙烷和基质的用量比例。环氧乙烷与甘油加成产物的C12/18脂肪酸单酯和二酯已知用作化妆制剂的富脂剂。优选的乳化剂在下文详细列出:
偏甘油酯。适当的偏甘油酯的典型实例是羟基硬脂酸单甘油酯、羟基硬脂酸二甘油酯、异硬脂酸单甘油酯、异硬脂酸二甘油酯、油酸单甘油酯、油酸二甘油酯、蓖麻酸单甘油酯、蓖麻酸二甘油酯、亚油酸单甘油酯、亚油酸二甘油酯、亚油酸单甘油酯、亚油酸二甘油酯、芥酸单甘油酯、芥酸二甘油酯、酒石酸单甘油酯、酒石酸二甘油酯、柠檬酸单甘油酯、柠檬酸二甘油酯、苹果酸单甘油酯、苹果酸二甘油酯及其仍含有少量源自生产过程的甘油三酯的技术混合物。1至30且优选5至10摩尔环氧乙烷与上述偏甘油酯的加成产物同样适当。
脱水山梨醇酯。适当的脱水山梨醇酯是脱水山梨醇单异硬脂酸酯、脱水山梨醇倍半异硬脂酸酯、脱水山梨醇二异硬脂酸酯、脱水山梨醇三异硬脂酸酯、脱水山梨醇单油酸酯、脱水山梨醇倍半油酸酯、脱水山梨醇二油酸酯、脱水山梨醇三油酸酯、脱水山梨醇单芥酸酯、脱水山梨醇倍半芥酸酯、脱水山梨醇二芥酸酯、脱水山梨醇三芥酸酯、脱水山梨醇单蓖麻酸酯、脱水山梨醇倍半蓖麻酸酯、脱水山梨醇二蓖麻酸酯、脱水山梨醇三蓖麻酸酯、脱水山梨醇单羟基硬脂酸酯、脱水山梨醇倍半羟基硬脂酸酯、脱水山梨醇二羟基硬脂酸酯、脱水山梨醇三羟基硬脂酸酯、脱水山梨醇单酒石酸酯、脱水山梨醇倍半酒石酸酯、脱水山梨醇二酒石酸酯、脱水山梨醇三酒石酸酯、脱水山梨醇单柠檬酸酯、脱水山梨醇倍半柠檬酸酯、脱水山梨醇二柠檬酸酯、脱水山梨醇三柠檬酸酯、脱水山梨醇单马来酸酯、脱水山梨醇倍半马来酸酯、脱水山梨醇二马来酸酯、脱水山梨醇三马来酸酯及其技术混合物。1至30且优选5至10摩尔环氧乙烷与上述脱水山梨醇酯的加成产物同样适当。
聚甘油酯。适当的聚甘油酯的典型实例是聚甘油-2二聚羟基硬脂酸酯(PGPH)、聚甘油-3-二异硬脂酸酯(TGI)、聚甘油-4异硬脂酸酯(GI 34)、聚甘油-3油酸酯、聚甘油-3二异硬脂酸酯(PDI)、聚甘油-3甲基葡糖二硬脂酸酯(Tego450)、聚甘油-3蜂蜡(Cera)、聚甘油-4癸酸酯(聚甘油癸酸酯T2010/90)、聚甘油-3鲸蜡基醚(NL)、聚甘油-3二硬脂酸酯(GS 32)和聚甘油聚蓖麻酸酯(WOL 1403)、聚甘油二异硬脂酸(polyglyceryl dimerate isostearate)酯及其混合物。其它适当的多元醇酯的实例是任选与1至30摩尔环氧乙烷反应的月桂酸、椰油酸、牛油酸、棕榈酸、硬脂酸、油酸、山嵛酸等与三羟甲基丙烷或季戊四醇的单酯、二酯和三酯。
烷基和/或烯基低聚糖苷。烷基和/或烯基低聚糖苷、其制备和用途是现有技术已知的。它们特别是通过使葡萄糖或低聚糖与含有8至18个碳原子的伯醇反应来制备。对于糖苷残基,优选单糖苷类,其中环状糖残基被糖苷键合到脂肪醇,以及低聚度优选高达约8的低聚糖苷。低聚度是基于此类技术产品惯常的同系物分布的统计平均值。
四烷基季铵盐。水溶液中阳离子活性表面活性剂含有解离阳离子中表面活性所需的疏水高分子基团。阳离子表面活性剂的重要代表是通式(R1R2R3R4N+)X-的四烷基季铵盐。其中R1代表C1-C8烷(烯)基,R2、R3和R4,相互独立地代表含有1至22个碳原子的烷(烯)基。X是反离子,优选自卤素、烷基硫酸盐和烷基碳酸盐。特别优选阳离子表面活性剂,其中氮原子被两个长酰基和两个短烷(烯)基取代。
酯季铵盐。特别用作本发明的助表面活性剂的一组阳离子表面活性剂是所谓的酯季铵盐。酯季铵盐通常是指季铵化脂肪酸三乙醇胺酯盐。它们是已知化合物,可以通过制备有机化学的相关方法得到。在这方面参考国际专利申请WO 91/01295A1,其中在次磷酸存在下三乙醇胺被脂肪酸部分酯化,将空气通过反应混合物,随后整体用硫酸二甲酯或环氧乙烷季铵化。此外,德国专利DE 4308794 C1记载了一种制备固体酯季铵盐的方法,其中三乙醇胺酯的季铵化在适当分散剂,优选脂肪醇的存在下进行。
根据本发明适当使用的酯季铵盐的典型实例是一种产品,其酰基成分源自对应于式RCOOH的单羧酸,其中RCO是含有6至10个碳原子的酰基,并且氨基成分是三乙醇胺(TEA)。这类单羧酸的实例是己酸、辛酸、癸酸及其技术混合物,如例如所谓的头分馏脂肪酸。优选使用的酯季铵盐,其酰基成分源自含有8至10个碳原子的单羧酸。其他酯季铵盐是那些产物,其酰基成分源自二元碳酸如丙二酸、琥珀酸、马来酸、富马酸、戊二酸、山梨酸、庚二酸、壬二酸、癸二酸和/或十二烷二酸,但优选己二酸。总之优选其酰基源自含有6至22个碳原子的单羧酸和己二酸的混合物的酯季铵盐。在最终的酯季铵盐中单羧酸和二元羧酸的摩尔比为1:99至99:1并且优选50:50至90:10并且特别是70:30至80:20。除了季铵化脂肪酸三乙醇胺酯盐,其他适当的酯季铵盐是单/二元羧酸混合物与二乙醇烷基胺或1,2-二羟基丙基二烷基胺。酯季铵盐可以由脂肪酸和相应的甘油三酯与相应二元羧酸混合得到。一种这类方法,其可以为被看为相关现有技术的代表,记载于欧洲专利EP 0750606 B1。为了生产季铵化酯,单和二元羧酸和三乙醇胺的混合物—基于可用的羧基功能—摩尔比可以为1.1:1至3:1。考虑到酯季铵盐的性能,已经证明特别有利的比例是1.2:1至2.2:1,并且优选1.5:1至1.9:1。优选的酯季铵盐是平均酯化度为1.5至1.9的单、二和三酯的技术混合物。
富脂剂和稠度因子
富脂剂可以选自物质如,例如羊毛脂和卵磷脂以及聚乙氧基化或酰基化羊毛脂和卵磷脂衍生物、多元醇脂肪酸酯、单甘油酯和脂肪酸烷醇酰胺,其中脂肪酸烷醇酰胺也可用作泡沫稳定剂。
使用的主要稠度因子是含有12至22个并且优选16至18个碳原子的脂肪族醇或羟基脂肪族醇以及偏甘油酯、脂肪酸或羟基脂肪酸。优选使用这些物质与烷基寡葡萄糖苷和/或相同链长的脂肪酸N-甲基葡糖酰胺和/或聚甘油聚-12-羟基硬脂酸酯的结合物。
增稠剂和流变添加剂
适当的增稠剂是聚合物增稠剂,如类(亲水性二氧化硅)、多糖,更特别是黄原胶、瓜尔胶、琼脂、藻酸盐和纤基乙酸钠(tyloses)、羧甲基纤维素和羟乙基和羟丙基纤维素、以及脂肪酸的相对高分子量聚乙二醇单酯和二酯、聚丙烯酸酯(例如[Goodrich]或[Sigma])、聚丙烯酰胺、聚乙烯醇和聚乙烯吡咯烷酮、表面活性剂如,例如乙氧基化脂肪酸甘油酯、脂肪酸与多元醇,如季戊四醇或三羟甲基丙烷的酯、窄同系物分布的脂肪族醇乙氧基化物和电解质,如氯化钠和氯化铵。
聚合物
合适的阳离子聚合物是例如阳离子纤维素衍生物,例如可从Amerchol以PolymerJR的名称获得的季铵化羟乙基纤维素、阳离子淀粉、二烯丙基铵盐和丙烯酰胺的共聚物、季铵化乙烯基吡咯烷酮/乙烯基咪唑聚合物,例如(BASF)、聚乙二醇和胺的缩合物、季铵化胶原多肽,例如月桂基二铵羟丙基水解胶原蛋白(L,Grünau)、季铵化小麦多肽、聚乙烯亚胺、阳离子有机硅聚合物,例如氨基聚二甲基硅氧烷、己二酸和二甲氨基羟丙基二亚乙基三胺的共聚物(Sandoz)、丙烯酸与二甲基二烯丙基氯化铵的共聚物(550,Chemviron)、聚氨基聚酰胺及其交联水溶性聚合物、阳离子几丁质衍生物,例如季铵化壳聚糖,任选微晶分布、二卤代烷,例如二溴丁烷,与双二烷基胺,例如双二甲氨基-1,3-丙烷的缩合产物、阳离子瓜尔胶如,的季铵盐聚合物,例如Miranol的A-15、AD-1、AZ-1、和可以在市场上以商品名CC或300找到的各种聚季铵盐类型(例如6、7、32或37)。
合适的阴离子、两性离子、两性和非离子聚合物是例如乙酸乙烯酯/巴豆酸共聚物、乙烯基吡咯烷酮/丙烯酸乙烯酯共聚物、乙酸乙烯酯/马来酸丁酯/丙烯酸异冰片酯共聚物、甲基乙烯基醚/马来酸酐共聚物及其酯、未交联和多元醇交联的聚丙烯酸、丙烯酰胺丙基三甲基氯化铵/丙烯酸酯共聚物、辛基丙烯酰胺/甲基丙烯酸甲酯/甲基丙烯酸叔丁基氨基乙酯/甲基丙烯酸2-羟丙酯共聚物、聚乙烯吡咯烷酮、乙烯基吡咯烷酮/乙酸乙烯酯共聚物、乙烯基吡咯烷酮/甲基丙烯酸二甲氨基乙酯/乙烯基己内酰胺三元共聚物和任选衍生的纤维素醚和有机硅。
珠光蜡
适当的珠光蜡是例如,烷二醇酯,尤其是乙二醇二硬脂酸酯;脂肪酸烷醇酰胺,尤其是椰油脂肪酸二乙醇酰胺;偏甘油酯,尤其是硬脂酸单甘油酯;多元、任选羟基取代的羧酸与具有6-22个碳原子的脂肪族醇的酯,尤其是酒石酸的长链酯;具有总计至少24个碳原子的脂肪物质,如例如脂肪族醇、脂肪酮、脂肪醛、脂肪醚和脂肪碳酸酯,尤其是月桂酮和二硬脂醚;脂肪酸如硬脂酸、羟基硬脂酸或山嵛酸、具有12-22个碳原子的环氧烯烃与具有12-22个碳原子的脂肪族醇和/或具有2-15个碳原子和2-10个羟基的多元醇的开环产物、及其混合物。
硅酮
适当的硅酮选自组包括:茶碱甲基硅烷醇甘露糖醛酸酯、乙酰甲硫氨酰基甲基硅烷醇弹性蛋白酯丙烯酸(酯)类/山嵛醇丙烯酸酯、丙烯酸(酯)类/山嵛醇甲基丙烯酸酯/聚二甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/山嵛醇甲基丙烯酸酯/聚二甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/双羟丙基聚二甲基硅氧烷交联聚合物、丙烯酸(酯)类/聚二甲基硅氧烷共聚物、丙烯酸(酯)类/聚二甲基硅氧烷甲基丙烯酸酯/丙烯酸乙基己酯共聚物、丙烯酸(酯)类/聚二甲基硅氧烷醇丙烯酸酯共聚物、丙烯酸(酯)类/丙烯酸乙基己酯/聚二甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/辛基丙烯酰胺/二苯基氨端聚二甲基硅氧烷共聚物、丙烯酸(酯)类/聚三甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/丙基聚三甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/硬脂醇丙烯酸酯/聚二甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/十三醇丙烯酸酯/三乙氧基甲硅烷基丙醇甲基丙烯酸酯/聚二甲基硅氧烷甲基丙烯酸酯共聚物、丙烯酸(酯)类/甲基丙烯酸三氟丙酯/聚三甲基硅氧烷甲基丙烯酸酯共聚物、氨基双丙基聚二甲基硅氧烷、氨乙基氨丙基聚二甲基硅氧烷、氨丙基聚二甲硅氧烷、氨丙基苯基聚三甲基硅氧烷、氨丙基三乙氧基硅烷、聚二甲基硅氧烷PEG-7硫酸酯铵、氨端聚二甲基硅氧烷、氨端聚二甲基硅氧烷羟基硬脂酸盐、氨端聚二甲基硅氧烷/硅倍半氧烷共聚物、抗坏血酸羧癸基三硅氧烷、抗坏血酸甲基硅烷醇果胶酸酯、山嵛氧基聚二甲基硅氧烷、山嵛基三甲基铵聚二甲基硅氧烷PEG-8邻苯二甲酸酯、山嵛基聚二甲基硅氧烷、双氨基PEG/PPG-41/3氨乙基PG-丙基聚二甲基硅氧烷、双-氨丙基/乙氧基氨丙基聚二甲基硅氧烷、双(苯甲酸丁酯)二氨基三嗪氨丙基三硅氧烷、双-丁基聚二甲基硅氧烷聚甘油-3、双-丁氧基氨端聚二甲基硅氧烷/PEG-60共聚物、双(C13-15烷氧基)羟基丁酰胺基氨端聚二甲基硅氧烷、双(C13-15烷氧基)PG-氨端聚二甲基硅氧烷、双-(C1-8烷基月桂酰赖氨酸癸基甲酰胺)聚二甲基硅氧烷、双-鲸蜡基鲸蜡基聚二甲基硅氧烷、双-鲸蜡基/PEG-8鲸蜡基PEG-8二甲基硅氧烷、双-二苯乙基二聚硅氧烷、双-乙基乙基聚甲基硅氧烷、双-葡糖酰胺乙基-氨丙基二聚硅氧烷、双-氢聚二甲基硅氧烷、双-羟基乙氧基丙基二聚硅氧烷双-羟月桂基、聚二甲基硅氧烷/IPDI共聚物、双-羟基/甲氧基氨端聚二甲基硅氧烷、双-羟基丙基二甲基硅氧烷山嵛酸酯、双-羟基丙基聚二甲基硅氧烷/SMDI共聚物、双-异丁基PEG-14/聚二甲基硅氧烷共聚物、双-异丁基PEG-15/聚二甲基硅氧烷共聚物、双-异丁基PEG/PPG-20/35/聚二甲基硅氧烷共聚物、双-异丁基PEG/PPG-10/7/聚二甲基硅氧烷共聚物、双-异丁基PEG-24/PPG-7/二聚二甲基硅氧烷共聚物、双-PEG-1聚二甲基硅氧烷、双-PEG-4聚二甲基硅氧烷、双-PEG-8聚二甲基硅氧烷、双-PEG-12聚二甲基硅氧烷、双-PEG-20聚二甲基硅氧烷、双-PEG-12聚二甲基硅氧烷蜂蜡酸酯、双-PEG-12聚二甲基硅氧烷坎地利拉蜡酸酯、双-PEG-15聚二甲基硅氧烷/IPDI共聚物、双-PEG-15甲醚聚二甲基硅氧烷、双-PEG-18甲基醚二甲基硅烷、双-PEG/PPG-14/14聚二甲基硅氧烷、双-PEG/PPG-15/5聚二甲基硅氧烷、双-PEG/PPG-18/6聚二甲基硅氧烷、双-PEG/PPG-20/20聚二甲基硅氧烷、双-PEG/PPG-16/16PEG/PPG-16/16聚二甲基硅氧烷、双-PEG/PPG-20/5PEG/PPG-20/5聚二甲基硅氧烷、双苯基六甲基硅氧烷、双-苯丙基聚二甲基硅氧烷、双聚乙烯聚二甲基硅氧烷、双(聚甘油-3羟苯基丙基)聚二甲硅氧烷、双-(聚甘油-7羟苯基丙基)聚二甲基硅氧烷、双-PPG-15聚二甲基硅氧烷/IPDI共聚物、双(PPG-7十一碳烯醇聚醚-21)聚二甲基硅氧烷、双-硬脂基聚二甲基硅氧烷、双-三甲氧硅乙基四甲基二硅氧乙基聚二甲基硅氧烷、双-乙烯基聚二甲基硅氧烷、双-乙烯基聚二甲基硅氧烷/聚二甲基硅氧烷共聚物、玻璃苣籽油PEG-7聚二甲基硅氧烷酯类、丙烯酸丁酯/C6-14全氟代烷基乙醇丙烯酸酯/巯丙基聚二甲基硅氧烷共聚物、丙烯酸丁酯/羟丙基聚二甲基硅氧烷丙烯酸酯共聚物、丁基聚二甲基硅氧烷丙烯酸酯/甲基丙烯酸环己酯/丙烯酸乙基己酯共聚物、丁基聚二甲基硅氧烷甲基丙烯酸酯/甲基丙烯酸甲酯交联聚合物、叔丁基二甲基甲硅烷葡萄籽提取物、丁基聚二甲基硅氧烷乙烯/丙烯/乙烯降冰片烯共聚物、C6-8烷基C3-6烷基葡糖苷聚二甲基硅氧烷、C20-24烷基聚二甲基硅氧烷、C24-28烷基聚二甲基硅氧烷、C26-28烷基聚二甲基硅氧烷、C30-45烷基聚二甲基硅氧烷、C30-60烷基聚二甲基硅氧烷、C32烷基聚二甲基硅氧烷、C30-45烷基聚二甲基硅氧烷/聚环己烯氧化物交联聚合物、C26-28烷醇二甲基甲硅烷聚丙基硅倍半氧烷、C30-45烷醇二甲基甲硅烷聚丙基硅倍半氧烷、C20-24烷基聚甲基硅氧烷、C24-28烷基聚甲基硅氧烷、C26-28烷基聚甲基硅氧烷、C30-45烷基聚甲基硅氧烷、C20-28烷基全氟癸基乙氧基聚二甲基硅氧烷、C26-54烷基十四烷剂聚二甲基硅氧烷、辛基聚二甲基硅氧烷、辛基聚二甲基硅氧烷乙氧基葡糖苷、辛基聚甲基硅氧烷、辛基聚三甲基硅氧烷、羧癸基三硅氧烷、蓖麻油双-羟丙基聚二甲基硅氧烷酯类、蜡基聚二甲基硅氧烷、鲸蜡硬脂基聚二甲基硅氧烷交联聚合物、鲸蜡硬脂基聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、鲸蜡硬脂基聚甲基硅氧烷、西曲铵羧癸基PEG-8聚二甲基硅氧烷盐、西曲铵聚二甲基硅氧烷PEG-7邻苯二甲酸酯盐、鲸蜡基山嵛醇聚二甲基硅氧烷盐、鲸蜡基聚二甲基硅氧烷、鲸蜡基聚二甲基硅氧烷/双乙烯基聚二甲硅氧烷交联聚合物、鲸蜡基二十六烷基聚二甲基硅氧烷、鲸蜡氧基聚二甲基硅氧烷、鲸蜡基PEG-8聚二甲基硅氧烷、鲸蜡基PEG/PPG-15/15丁基醚聚二甲基硅氧烷、鲸蜡基PEG/PPG-7/3聚二甲基硅氧烷、鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷、鲸蜡基三乙基铵聚二甲基硅氧烷PEG-8邻苯二甲酸酯、鲸蜡基三乙基铵聚二甲基硅氧烷PEG-8琥珀酸酯、乙酰酪氨酸铜甲基硅烷醇、PCA甲基硅烷醇铜、C4-14全氟代烷基乙氧基聚二甲基硅氧烷、环乙氧基聚甲基硅氧烷、环庚硅氧烷、环己硅氧烷、环聚二甲基硅氧烷、环五聚二甲基硅氧烷、环苯基聚甲基硅氧烷、环四聚二甲基硅氧烷、环乙烯基聚甲氧基硅烷、胱氨酸双-PG-丙基硅烷三醇、DEA PG-丙基PEG/PPG-18/21聚二甲基硅氧烷、二异硬脂酰基三羟甲基丙烷硅烷氧基硅酸酯、二月桂酰基三羟甲基丙烷硅氧烷基硅酸酯、二聚亚油酰胺丙基二甲胺聚二甲硅氧烷PEG-7磷酸酯、聚二甲基硅氧烷、聚二甲基硅氧烷交联聚合物、聚二甲基硅氧烷交联聚合物-3、聚二甲基硅氧烷/二乙烯基聚二甲硅氧烷/硅倍半氧烷交联聚合物、聚二甲基硅氧烷乙氧基葡糖苷、聚二甲基硅氧烷羟丙基三甲基氯化铵、聚二甲基硅氧烷/巯丙基聚甲基硅氧烷共聚物、聚二甲基硅氧烷PEG-15乙酸酯、聚二甲基硅氧烷PEG-8己二酸酯,聚二甲基硅氧烷PEG-7鳄梨油酸酯、聚二甲基硅氧烷PEG-8鳄梨油酸酯、聚二甲基硅氧烷PEG-8蜂蜡酸酯、聚二甲基硅氧烷PEG-8苯甲酸酯、聚二甲基硅氧烷PEG-8玻璃苣油酸酯、聚二甲基硅氧烷PEG-7椰油酸酯、聚二甲基硅氧烷/PEG-10交联聚合物、聚二甲基硅氧烷PEG-10/15交联聚合物、聚二甲基硅氧烷PEG-15交联聚合物、聚二甲基硅氧烷PEG-7异硬脂酸酯、聚二甲基硅氧烷PEG-8异硬脂酸酯、聚二甲基硅氧烷PEG-7乳酸酯、聚二甲基硅氧烷PEG-8羊毛脂酸酯、聚二甲基硅氧烷PEG-8月桂酸酯、聚二甲基硅氧烷PEG-8白池花籽油酸酯、聚二甲基硅氧烷PEG-7辛基十二醇柠檬酸酯、聚二甲基硅氧烷PEG-7橄榄油酸酯、聚二甲基硅氧烷PEG-8橄榄油酸酯、聚二甲基硅氧烷PEG-7磷酸酯、聚二甲基硅氧烷PEG-8磷酸酯、聚二甲基硅氧烷PEG-10磷酸酯、聚二甲基硅氧烷PEG-7邻苯二甲酸酯、聚二甲基硅氧烷PEG-8邻苯二甲酸酯、聚二甲基硅氧烷PEG-8聚丙烯酸酯、聚二甲基硅氧烷PEG/PPG-20/23苯甲酸酯、聚二甲基硅氧烷PEG/PPG-7/4磷酸酯、聚二甲基硅氧烷PEG/PPG-12/4磷酸酯、聚二甲基硅氧烷PEG-7琥珀酸酯、聚二甲基硅氧烷PEG-8琥珀酸酯、聚二甲基硅氧烷PEG-7硫酸酯,聚二甲基硅氧烷PEG-7十一酸酯、聚二甲基硅氧烷PG-二乙基甲基氯化铵、聚二甲基硅氧烷/苯基乙烯基聚二甲硅氧烷交联聚合物、聚二甲基硅氧烷/聚甘油-3交联聚合物、聚二甲基硅氧烷/PPG-20交联聚合物、聚二甲基硅氧烷丙基乙二胺山嵛酸盐、聚二甲基硅氧烷丙基PG-甜菜碱、聚二甲基硅氧烷/硅倍半氧烷共聚物、甲硅烷基化聚二甲基硅氧烷、聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、聚二甲基硅氧烷/乙烯基三甲基硅烷氧基硅酸酯交联聚合物、聚二甲基硅氧烷醇、聚二甲基硅氧烷醇精氨酸、聚二甲基硅氧烷醇蜂蜡酸酯、聚二甲基硅氧烷醇山嵛酸酯、聚二甲基硅氧烷醇玻璃苣酸酯、聚二甲基硅氧烷醇小烛树蜡酸酯、聚二甲基硅氧烷醇巴西棕榈酸酯、聚二甲基硅氧烷醇半胱氨酸、聚二甲基硅氧烷醇德鲁巴脂酸酯、聚二甲基硅氧烷醇氟代醇二聚亚油酸聚酯、聚二甲基硅氧烷醇羟基硬脂酸酯、聚二甲基硅氧烷醇印度赤铁树脂酸酯、聚二甲基硅氧烷醇/IPDI共聚物、聚二甲基硅氧烷醇异硬脂酸酯、聚二甲基硅氧烷醇烛果脂酸酯、聚二甲基硅氧烷醇乳酸酯、聚二甲基硅氧烷醇白池花籽油酸酯、聚二甲基硅氧烷醇蛋氨酸、聚二甲基硅氧烷醇/甲基硅烷醇/硅酸酯交联聚合物、聚二甲基硅氧烷醇长叶雾冰藜木脂酸酯、聚二甲基硅氧烷醇泛醇、聚二甲基硅氧烷醇柳安脂酸酯、聚二甲基硅氧烷/硅石交联聚合物、聚二甲基硅氧烷醇/硅倍半氧烷共聚物、聚二甲基硅氧烷醇硬脂酸酯、聚二甲基硅氧烷醇/硬脂基聚甲基硅氧烷/苯基聚三甲基硅氧烷共聚物、二甲氧硅烷基亚乙基二氨丙基聚二甲基硅氧烷、二甲氨基丙酰胺基PCA聚二甲基硅氧烷、二甲基氧代苯并二噁硅烷、二甲基甲硅烷醇透明质酸酯、二油基生育酚甲基硅烷醇、二苯基氨端聚二甲基硅氧烷、二苯基聚二甲基硅氧烷、二苯基聚二甲基硅氧烷交联聚合物、二苯基聚二甲基硅氧烷/乙烯基二苯基聚二甲基硅氧烷/硅倍半氧烷交联聚合物、二苯乙基苄氧基二甲基二硅氧烷、二苯基异丙基聚二甲基硅氧烷、二苯基甲硅烷氧基苯基/丙基聚三甲基硅氧烷、二苯基甲硅烷氧基苯基聚三甲基硅氧烷、二聚硅氧烷、氨端聚二甲基硅氧烷/二琥珀酰亚胺二钠、PEG-12聚二甲基硅氧烷磺基琥珀酸酯二钠,PEG-8月桂基聚二甲基硅氧烷磺基琥珀酸酯二钠、二乙烯基聚二甲基硅氧烷/聚二甲基硅氧烷共聚物、二乙烯基聚二甲基硅氧烷/聚二甲基硅氧烷交联聚合物、甲酚曲唑三硅氧烷、丙烯酸乙基己酯/VP/聚二甲基硅氧烷甲基丙烯酸酯共聚物、乙基聚甲基硅氧烷、乙基三硅氧烷、氟代C2-8烷基聚二甲基硅氧烷、葡糖酰胺丙基氨丙基聚二甲基硅氧烷、4-(2-β-吡喃葡糖甲硅氧基)丙氧基-2-羟基二苯甲酮、甘油十一烷基聚二甲基硅氧烷、环氧丙氧基聚二甲基硅氧烷、聚十六烷基甲基硅氧烷、己基聚二甲基硅氧烷、己基聚甲基硅氧烷、己基三甲氧基硅烷、氢化聚二甲基硅氧烷、氢化聚二甲基硅氧烷/辛基硅倍半氧烷共聚物、水解胶原PG-丙基聚二甲基硅氧烷醇、水解胶原PG-丙基甲基硅烷二醇、水解胶原PG-丙基硅烷三醇、水解角蛋白PG-丙基甲基硅烷二醇、水解芝麻蛋白PG-丙基甲基硅烷二醇、水解蚕丝PG-丙基甲基硅烷二醇、水解蚕丝PG-丙基甲基硅烷二醇交联聚合物、水解大豆蛋白/聚二甲基硅氧烷PEG-7乙酸酯、水解大豆蛋白PG-丙基甲基硅烷二醇、水解植物蛋白PG-丙基硅烷三醇、水解小麦(TRITICUM VULGARE)蛋白/胱氨酸双-PG-丙基硅烷三醇共聚物、水解小麦蛋白/聚二甲基硅氧烷PEG-7乙酸酯、水解小麦蛋白/聚二甲基硅氧烷PEG-7磷酸酯共聚物、水解小麦蛋白PG-丙基甲基硅烷二醇、水解小麦蛋白PG-丙基硅烷三醇、羟乙基乙酰氧基甲基铵PG-聚二甲基硅氧烷、羟丙基聚二甲基硅氧烷、羟丙基聚二甲基硅氧烷山嵛酸酯、羟丙基聚二甲基硅氧烷异硬脂酸酯、羟丙基聚二甲基硅氧烷硬脂酸酯、甲基丙烯酸异丁酯/双-羟丙基聚二甲基硅氧烷丙烯酸酯共聚物、甲基丙烯酸异丁酯/甲基丙烯酸三氟乙酯/双-羟丙基聚二甲基硅氧烷丙烯酸酯共聚物、异戊醇三甲氧基肉桂酸酯三硅氧烷、异聚甘油-3聚二甲基硅氧烷、异聚甘油-3聚二甲基硅氧烷醇、异丙基钛三异硬脂酸酯/三乙氧基甲硅烷基乙基、聚二甲基硅氧乙基聚二甲基硅氧烷交联聚合物、异硬脂基羧癸基PEG-8聚二甲基硅氧烷、乳酰基甲基硅烷醇弹性蛋白酯、月桂基聚二甲基硅氧烷、月桂基聚二甲基硅氧烷PEG-15交联聚合物、月桂基聚二甲基硅氧烷PEG-10磷酸酯、月桂基聚二甲基硅氧烷/聚甘油-3交联聚合物、月桂基聚甲基硅氧烷、月桂基PEG-8聚二甲基硅氧烷、桂基PEG-10甲醚聚二甲基硅氧烷、月桂基PEG-9聚二甲基硅氧乙基聚二甲基硅氧烷、月桂基PEG/PPG-18/18聚甲基硅氧烷、月桂基苯异丙基聚甲基硅氧烷、月桂基苯丙基聚甲基硅氧烷、月桂基聚二甲基硅氧乙基聚二甲基硅氧烷/双乙烯基聚二甲硅氧烷交联聚合物、月桂基聚甘油-3聚二甲基硅氧乙基聚二甲基硅氧烷、月桂基聚三甲基硅氧烷、亚油酰胺丙基PG-二甲基氯化铵磷酸酯聚二甲基硅氧烷、甲基丙烯酰基丙基三甲氧基硅烷、聚甲基硅氧烷、甲氧基氨端聚二甲基硅氧烷/硅倍半氧烷共聚物、甲氧基肉桂酰胺丙基聚硅倍半氧烷、甲氧基肉桂酰丙基硅倍半氧烷硅酸盐、甲氧基PEG-13乙基聚硅倍半氧烷、甲氧基PEG/PPG-7/3氨丙基聚二甲基硅氧烷、甲氧基PEG/PPG-25/4聚二甲基硅氧烷、甲氧基PEG-10丙基三甲氧基硅烷、甲基丁香酚PEG-8聚二甲基硅氧烷、甲基聚硅氧烷乳液、甲基硅烷醇乙酰蛋氨酸酯、甲基硅烷醇乙酰酪氨酸酯、甲基硅烷醇抗坏血酸、甲基硅烷醇羧甲基茶碱、甲基硅烷醇羧甲基茶碱藻酸盐、甲基硅烷醇弹性蛋白酯、甲基硅烷醇甘草酸酯、甲基硅烷醇羟脯氨酸酯、甲基硅烷醇羟脯氨酸酯天冬氨酸酯、甲基硅烷醇甘露糖醛酸酯、甲基硅烷醇PCA酯、甲基硅烷醇PEG-7甘油椰油酸酯、甲基硅烷醇/硅酸酯交联聚合物、甲基硅烷醇螺旋藻蛋白酯、甲基硅烷醇三-PEG-8甘油基椰油酸酯、甲基聚三甲基硅氧烷、甲基三甲氧基硅烷、肉豆蔻酰胺丙基二甲基胺聚二甲基硅氧烷PEG-7磷酸酯、肉豆蔻基聚甲基硅氧烷、肉豆蔻基三硅氧烷、锦纶-611/聚二甲基硅氧烷共聚物、PCA聚二甲基硅氧烷、PEG-7氨端聚二甲基硅氧烷、PEG-8氨端聚二甲基硅氧烷、PEG-8鲸蜡基聚二甲基硅氧烷、PEG-3聚二甲基硅氧烷、PEG-6聚二甲基硅氧烷、PEG-7聚二甲基硅氧烷、PEG-8聚二甲基硅氧烷、PEG-9聚二甲基硅氧烷、PEG-10聚二甲基硅氧烷、PEG-12聚二甲基硅氧烷、PEG-14聚二甲基硅氧烷、PEG-聚二甲基硅氧烷、PEG-10聚二甲基硅氧烷交联聚合物、PEG-12聚二甲基硅氧烷交联聚合物、PEG-8聚二甲基硅氧烷二聚亚油酸酯、PEG-8二聚亚油酸酯/二聚亚油酸共聚物、PEG-10聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物、PEG-8二硬脂基甲基氯化铵PG-聚二甲基硅氧烷、PEG-10/月桂基聚二甲基硅氧烷交联聚合物、PEG-15/月桂基聚二甲基硅氧烷交联聚合物、PEG-15/月桂基聚二甲基硅氧乙基聚二甲基硅氧烷交联聚合物、PEG-8聚甲基硅氧烷、PEG-6聚甲基硅氧烷乙酸酯、PEG-6甲醚聚二甲基硅氧烷、PEG-7甲醚聚二甲基硅氧烷、PEG-8甲醚聚二甲基硅氧烷、PEG-9甲醚聚二甲基硅氧烷、PEG-10甲醚聚二甲基硅氧烷、PEG-11甲醚聚二甲基硅氧烷、PEG-32甲醚聚二甲基硅氧烷、PEG-8PEG-8甲基醚三乙氧基硅烷、PEG-10九氟代己基聚二甲基硅氧烷共聚物、PEG-4PEG-12聚二甲基硅氧烷、PEG-8PG椰油酰葡糖苷聚二甲基硅氧烷、PEG-9聚二甲基硅氧乙基聚二甲基硅氧烷、PEG/PPG-20/22丁醚聚二甲基硅氧烷、PEG/PPG-22/22丁醚聚二甲基硅氧烷、PEG/PPG-23/23丁醚聚二甲基硅氧烷、PEG/PPG-24/18丁醚聚二甲基硅氧烷、PEG/PPG-27/9丁醚聚二甲基硅氧烷、PEG/PPG-3/10聚二甲基硅氧烷、PEG/PPG-4/12聚二甲基硅氧烷、PEG/PPG-6/4聚二甲基硅氧烷、PEG/PPG-6/11聚二甲基硅氧烷、PEG/PPG-8/14聚二甲基硅氧烷、PEG/PPG-8/26聚二甲基硅氧烷、PEG/PPG-10/2聚二甲基硅氧烷、PEG/PPG-12/16聚二甲基硅氧烷、PEG/PPG-12/18聚二甲基硅氧烷、PEG/PPG-14/4聚二甲基硅氧烷、PEG/PPG-15/5聚二甲基硅氧烷、PEG/PPG-15/15聚二甲基硅氧烷、PEG/PPG-16/2聚二甲基硅氧烷、PEG/PPG-16/8聚二甲基硅氧烷、PEG/PPG-17/18聚二甲基硅氧烷、PEG/PPG-18/6聚二甲基硅氧烷、PEG/PPG-18/12聚二甲基硅氧烷、PEG/PPG-18/18聚二甲基硅氧烷、PEG/PPG-19/19聚二甲基硅氧烷、PEG/PPG-20/6聚二甲基硅氧烷、PEG/PPG-20/15聚二甲基硅氧烷、PEG/PPG-20/20聚二甲基硅氧烷、PEG/PPG-20/23聚二甲基硅氧烷、PEG/PPG-20/29聚二甲基硅氧烷、PEG/PPG-22/23聚二甲基硅氧烷、PEG/PPG-22/24聚二甲基硅氧烷、PEG/PPG-23/6聚二甲基硅氧烷、PEG/PPG-25/25聚二甲基硅氧烷、PEG/PPG-27/27聚二甲基硅氧烷、PEG/PPG-30/10聚二甲基硅氧烷、PEG/PPG-25/25聚二甲基硅氧烷/丙烯酸(酯)类共聚物、PEG/PPG-20/22甲醚聚二甲基硅氧烷、PEG/PPG-24/24甲基醚环氧丙氧基聚二甲基硅氧烷、PEG/PPG-10/3油基醚聚二甲基硅氧烷、PEG/PPG-5/3三硅氧烷、PEG-4三氟代丙基聚二甲基硅氧烷共聚物、PEG-8三氟代丙基聚二甲基硅氧烷共聚物、PEG-10三氟代丙基聚二甲基硅氧烷共聚物、PEG-8三硅氧烷、全氟辛烷基三乙氧基甲硅烷基乙基聚甲基硅氧烷、全氟壬基聚二甲基硅氧烷、全氟壬基聚二甲基硅氧烷/聚甲基硅氧烷/氨端聚二甲基硅氧烷交联聚合物、全氟壬基乙基羧癸基山嵛基聚二甲基硅氧烷、全氟壬基乙基羧癸基二十六烷基聚二甲基硅氧烷、全氟壬基乙基羧癸基月桂基/山嵛基聚二甲基硅氧烷、全氟壬基乙基羧癸基月桂基聚二甲基硅氧烷、全氟壬基乙基羧癸基PEG-8聚二甲基硅氧烷、全氟壬基乙基羧癸基PEG-10聚二甲基硅氧烷、全氟壬基乙基聚二甲基硅氧烷/聚甲基硅氧烷共聚物、全氟壬基乙基PEG-8聚二甲基硅氧烷、全氟壬基乙基硬脂基聚二甲基硅氧烷、全氟辛基乙基/二苯基聚二甲基硅氧烷共聚物、全氟辛基乙基三乙氧基硅烷、全氟辛基乙醇三甲氧基硅烷、全氟辛基乙基三硅氧烷、全氟辛基三乙氧基硅烷、PG-氨端聚二甲基硅氧烷、苯乙基聚二甲硅氧烷、苯乙基二硅氧烷、二苯基聚二甲基硅氧烷、二苯基异丙基聚二甲基硅氧烷、苯基聚甲基硅氧烷、苯基聚甲基硅氧烷醇、苯丙基二甲基硅烷氧基硅酸酯、苯丙基乙基聚甲基硅氧烷、苯基丙基聚三甲基硅氧烷、苯基丙基聚三甲基硅氧烷/二苯基聚甲基硅氧烷、苯基聚三甲基硅氧烷、二乙烯基二硅氧烷铂、聚丙烯酸酯-6、聚二乙基硅氧烷、聚二甲基硅羟乙基聚二甲基硅氧烷/双乙烯基聚二甲硅氧烷交联聚合物、聚二甲基硅氧乙基聚二甲基硅氧烷/聚甲基硅氧烷共聚物、聚二甲基硅氧PEG/PPG-24/19丁基醚硅倍半氧烷、聚二甲基硅氧PPG-13丁基醚硅倍半氧烷、聚甘油-3二硅氧烷聚二甲基硅氧烷、聚甘油-3/月桂基聚二甲基硅氧乙基聚二甲基硅氧烷交联聚合物、聚甘油-3聚二甲基硅羟乙基聚二甲基硅氧烷、聚(乙二醇己二酸酯)/双羟乙氧基丙基聚二甲基硅氧烷共聚物、聚甲基硅倍半氧烷、聚甲基硅倍半氧烷/三甲基硅氧基硅酸酯、聚苯基倍半硅氧烷、聚丙基硅倍半氧烷、聚硅氧烷-1、聚硅氧烷-2、聚硅氧烷-3、聚硅氧烷-4、聚硅氧烷-5、聚硅氧烷-6、聚硅氧烷-7、聚硅氧烷-8、聚硅氧烷-9、聚硅氧烷-10、聚硅氧烷-11、聚硅氧烷-12、聚硅氧烷-13、聚硅氧烷-14、聚硅氧烷-15、聚硅氧烷-16、聚硅氧烷-17、聚硅氧烷-18、聚硅氧烷-19、聚硅氧烷-20、聚硅氧烷-21、聚硅氧烷-18鲸蜡醇磷酸酯、聚硅氧烷-1交联聚合物、聚硅氧烷-18硬脂酸酯聚氨酯-10、甲基硅氧烷PEG-7泛醇磷酸酯钾、聚二甲基硅氧烷PEG-7磷酸酯钾、PPG-12丁醚聚二甲基硅氧烷、PPG-2聚二甲基硅氧烷、PPG-12聚二甲基硅氧烷、PPG-27聚二甲基硅氧烷、PPG-4油醇聚醚-10聚二甲基硅氧烷、丙氧基四甲基哌啶基聚二甲基硅氧烷、丙基聚三甲基硅氧烷、季铵盐-80、视黄氧基三甲基硅烷、硅烷二醇水杨酸酯、硅烷三醇、硅烷三醇精氨酸酯、硅烷三醇谷氨酸酯、硅烷三醇赖氨酸酯、硅烷三醇黑色素酯、硅烷三醇海藻糖醚、硅石、聚二甲基硅氧烷甲硅烷基化硅石、二甲基甲硅烷基化硅石、甲硅烷基化硅石、硅碳化物、聚硅氧烷季铵盐-1、聚硅氧烷季铵盐-2、聚硅氧烷季铵盐-2泛醇琥珀酸酯、聚硅氧烷季铵盐-3、聚硅氧烷季铵盐-4、聚硅氧烷季铵盐-5、聚硅氧烷季铵盐-6、聚硅氧烷季铵盐-7、聚硅氧烷季铵盐-8、聚硅氧烷季铵盐-9、聚硅氧烷季铵盐-10、聚硅氧烷季铵盐-11,聚硅氧烷季铵盐-12,聚硅氧烷季铵盐-15、聚硅氧烷季铵盐-16、聚硅氧烷季铵盐-16/环氧丙氧基聚二甲基硅氧烷交联聚合物、聚硅氧烷季铵盐-17、聚硅氧烷季铵盐-18、聚硅氧烷季铵盐-19、聚硅氧烷季铵盐-20、聚硅氧烷季铵盐-21、聚硅氧烷季铵盐-22、聚硅氧烷季铵盐-24、聚硅氧烷季铵盐-25、硅氧烷三醇藻酸酯、硅氧烷三醇植酸酯、有机硅树脂、羧癸基PEG-8聚二甲基硅氧烷钠、聚二甲基硅氧烷PEG-7乙酰甲基牛磺酸钠、二甲基硅烷醇透明质酸酯钠、乳酸钠甲基硅烷醇、甘露糖醛酸钠甲基硅烷醇、PCA钠甲基硅烷醇、PG-丙基聚二甲基硅氧烷硫代硫酸酯共聚物钠、PG-丙基硫代硫酸钠聚二甲基硅氧烷、丙氧基羟基丙基硫代硫酸酯钠硅石、山梨醇硅烷二醇、大豆三乙氧基甲硅烷基丙基二甲基氯化铵、司拉氯铵聚二甲基硅氧烷PEG-8邻苯二甲酸酯盐、硬脂酰胺丙基聚二甲硅氧烷、硬脂基二甲基铵羟丙基泛醇基PEG-7聚二甲基硅氧烷磷酸酯氯化物、硬脂基二甲基铵羟丙基PEG-7聚二甲基硅氧烷磷酸酯氯化物、硬脂氧基聚二甲硅氧烷、硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、硬脂氧基三甲基硅烷、硬脂基氨丙基聚甲基硅氧烷、硬脂基聚二甲硅氧烷、硬脂醇/月桂醇甲基丙烯酸酯交联聚合物、硬脂基聚甲基硅氧烷、硬脂基三乙氧基硅烷、硬脂基聚三甲基硅氧烷、苯乙烯/丙烯酸(酯)类/聚二甲基硅氧烷丙烯酸酯交联聚合物、苯乙烯/丙烯酸(酯)类/聚二甲基硅氧烷共聚物、聚二甲基硅氧烷PEG-7磷酸酯TEA盐、(四丁氧基)丙基三硅氧烷、四甲基六苯基四硅氧烷、四甲基四苯基三聚硅氧烷、生育酚氧丙基三硅氧烷、十三烷醇聚醚-9PG-氨端聚二甲基硅氧烷、三乙氧基辛基硅烷、聚二甲基硅氧烷/聚甲基硅氧烷共聚物、三乙氧基甲硅烷基乙基聚二甲基硅氧乙基聚二甲基硅氧烷、三乙氧基甲硅烷基乙基聚二甲基硅氧乙基己基聚二甲基硅氧烷、三乙氧基甲硅烷基丙基氨基甲酰乙氧基丙基丁基聚二甲基硅氧烷、三氟甲基C1-4烷基聚二甲基硅氧烷、三氟丙基环五硅氧烷、三氟丙基环四硅氧烷、三氟代丙基聚二甲基硅氧烷、三氟丙基聚二甲基硅氧烷/PEG-10交联聚合物、三氟丙基聚二甲基硅氧烷/三氟丙基二乙烯基聚二甲基硅氧烷交联聚合物、三氟丙基聚二甲基硅氧烷/乙烯基三氟丙基聚二甲基硅氧烷/硅倍半氧烷交联聚合物、三氟丙基聚二甲基硅氧烷醇、三氟丙基二甲基/三甲基硅氧基硅酸酯、三氟丙基聚甲基硅氧烷、三甲氧基辛基硅烷、三甲氧基甲硅烷基聚二甲基硅氧烷、三甲基五苯基三硅氧烷、三甲基甲硅烷氧基氨端聚二甲基硅氧烷、三甲基硅烷氧苯基聚二甲基硅氧烷、三甲基硅烷氧基硅酸酯、三甲基硅烷氧基硅酸酯/聚二甲基硅氧烷交联共聚物、三甲基硅烷氧基硅酸酯/聚二甲基硅氧烷醇交联聚合物、三甲基硅烷氧基甲硅烷基氨基甲酰支链淀粉、三甲基甲硅烷基水解贝壳硬蛋白PG-丙基甲基硅烷二醇交联聚合物、三甲基甲硅烷基水解蚕丝PG-丙基甲基硅烷二醇交联聚合物、三甲基甲硅烷基水解小麦蛋白PG-丙基甲基硅烷二醇交联聚合物、三甲基甲硅烷基支链淀粉、三甲基硅烷醇三硅甲烷氧基乙醇酸酯、三甲基甲硅烷醇三硅甲烷氧基乳酸酯、三甲基甲硅烷醇三硅甲烷氧基水杨酯、聚三苯基三甲基硅氧烷、三硅氧烷、三(三丁氧基甲硅烷氧基)甲基硅烷、十一碳烯聚二甲基硅氧烷、乙烯基聚二甲基硅氧烷、乙烯基聚二甲基硅氧烷/月桂基聚二甲基硅氧烷交联聚合物、乙烯基聚二甲基硅氧烷/聚甲基硅氧烷硅倍半氧烷交联聚合物、乙烯基二甲基/三甲基硅氧基硅酸酯/硬脂基聚二甲基硅氧烷交联聚合物、VP/甲基丙烯酸二甲氨基乙酯/聚氨基甲酸聚乙二醇酯、羧癸基三硅氧烷锌和聚二甲基硅氧烷PEG-8琥珀酸锌及其混合物。
根据本发明的混合物中所含的有机硅更优选为聚二甲基硅氧烷、环聚二甲基硅氧烷、苯基三甲基硅油,环己硅氧烷和环五聚二甲基硅氧烷。适当的挥发硅氧烷化合物的详细介绍见于Todd et al.in Cosm.Toil.91,27(1976)。
蜡和稳定剂
除了使用的天然油,制剂中还可以含有蜡,尤其是天然蜡例如,小烛树蜡、巴西棕榈蜡、日本蜡、芦华草腊(espartograss wax)、软木蜡、小冠椰子腊(guaruma wax)、米糠油蜡、糖甘蔗蜡、小冠巴西棕蜡(ouricury wax)、褐煤蜡、蜂蜡、紫胶蜡(shellac wax)、鲸蜡、羊毛脂(wool wax)、尾脂脂肪(uropygial fat)、(纯)地蜡、地蜡(石蜡)、凡士林、石油蜡和微蜡;化学改性的蜡类(硬蜡类)如例如,褐煤酯蜡(montan ester waxes)、沙索蜡(sasolwaxes)、氢化霍霍巴蜡(jojoba waxes)以及合成蜡类如例如聚亚烷基蜡类和聚乙二醇蜡类。
作为稳定剂可以使用脂肪酸的金属盐,如例如硬脂酸或蓖麻酸镁、铝和/或锌盐。
主要防晒剂
在本发明中主要防晒剂是,例如在室温下是液态或结晶的有机物质(光过滤物质),其能够吸收紫外辐射并又以长波辐射的形式释放吸收的能量,例如热量。
根据本发明的制剂有利地含有至少一种UV-A过滤物质和/或至少一种UV-B过滤物质和/或宽带过滤物质和/或至少一种无机染料。根据本发明的制剂优选含有至少一种UV-B过滤物质或一种宽带过滤物质,更特别是至少一种UV-A过滤物质和至少一种UV-B过滤物。
下文引用的可在本发明中使用的UV过滤物质是优选的,但不限于这些物质。优选使用的UV过滤剂选自以下种类中的一种、两种、三种、四种、五种或更多种
在一个优选的实施方案中,形成防晒过滤剂的组分(ii)代表UV-A-和UV-B-过滤剂的共混物,其选自高水杨酸盐、奥克立林、双-乙基己氧基苯酚甲氧基苯基三嗪、丁基甲氧基二苯并-基甲烷、水杨酸乙基己酯及其混合物。特别优选的是所有这些过滤剂的混合物,其可在市场上以商标Flat(SYMRISE)商购,其也为WO 2020088778A1的主题。
合适的颜料包括钛(TIO2)、锌(ZNO)、铁(FE2O3)、锆(ZRO2)、硅(SIO2)、锰(例如MNO)、铝(AL2O3)、铈(例如CE2O3)的氧化物和/或其混合物。
在进一步优选的实施方案中,根据本发明的制剂包含总量的防晒剂,即特别是UV过滤剂和/或无机颜料(UV过滤颜料),使得根据本发明的制剂具有光大于或等于5且至多50的保护因子。根据本发明的此类制剂特别适用于保护皮肤和头发。
二级防晒剂
除了上述主要防晒剂组,也可以使用抗氧化剂型的二级防晒剂。抗氧化剂型的二级防晒剂阻断了当紫外线渗透进入皮肤时引发的光化学反应链。典型实例是氨基酸类(例如甘氨酸、组氨酸、酪氨酸、色氨酸)及其衍生物、咪唑类(例如尿刊酸)及其衍生物、肽类例如D,L-肌肽、D-肌肽,L-肌肽及其衍生物(例如鹅肌肽)、类胡萝卜素类、胡萝卜素类(例如α-胡萝卜素、β-胡萝卜素、番茄红素)及其衍生物、氯原酸及其衍生物、硫辛酸及其衍生物(例如二氢硫辛酸)、金硫葡糖、丙基硫氧嘧啶和其他硫醇(例如硫氧还蛋白、谷胱甘肽、半胱氨酸、胱氨酸、胱胺及其糖基、N-乙酰基、甲基、乙基、丙基、戊基、丁基和月桂基、棕榈酰基、油烯基、α-亚油酰基、胆甾醇基和其甘油酯)及其盐、硫代二丙酸二月桂酯、硫代二丙酸双十八酯、硫代二丙酸及其衍生物(酯类、醚类、肽类、脂类、核苷酸类、核苷类和盐)以及非常低的耐药剂量的亚砜亚胺化合物(例如丁硫氨酸亚砜亚胺、同型半胱氨酸亚砜亚胺、丁硫氨酸砜、五-、六-和七-硫氨酸亚砜亚胺)、以及(金属)螯合剂类(例如,α-羟基脂肪酸类、棕榈酸、植酸、乳铁蛋白)、α-羟基酸类(例如柠檬酸、乳酸、苹果酸)、腐殖酸、胆汁酸、胆汁提取物、胆红素、胆绿素、EDTA、EGTA及其衍生物、不饱和脂肪酸及其衍生物(例如亚油酸、油酸)、叶酸及其衍生物、泛醌和泛醇及其衍生物、维生素C及其衍生物(例如抗坏血酸棕榈酸酯、抗坏血酸磷酸镁、抗坏血酸乙酸酯)、生育酚及衍生物(例如维生素E乙酸酯)、维生素A及衍生物(维生素A棕榈酸酯)以及安息香树脂的苯甲酸松酯、芸香十烯酸及其衍生物、糖基芦丁、阿魏酸、亚糠基山梨醇、肌肽、丁基羟甲苯、丁基羟基茴香醚、去甲二氢愈创木酸木脂酸、去甲二氢愈创木酸、三羟基丁酰苯、尿酸及其衍生物、甘露糖及其衍生物、超氧化物歧化酶、二氧化钛(例如乙醇中的分散体)、锌及其衍生物(例如ZnO、ZnSO4)、硒及其衍生物(例如蛋氨酸硒)、芪类及其衍生物(例如均二苯乙烯氧化物、反-均二苯乙烯氧化物)及这些活性化合物的适合本发明目的的衍生物(盐类、酯类、醚类、糖类、核苷酸类、核苷类、肽类和脂类)。
有利的无机二级光保护颜料是精细分散的金属氧化物和金属盐,它们也在WO2005 123101 A1中提及。在根据本发明的成品化妆品制剂中无机颜料,特别是疏水性无机微颜料的总量有利地为0.1至30重量%,优选0.5至10.0重量%,在每种情况下基于制剂的总重量计。
还优选的是颗粒状UV过滤剂或无机颜料,它们可以任选地被疏水化,可以使用,例如钛锌(ZnO)、铁(Fe2O3)、锆(Fe2O3),硅(SiO2)、锰(例如MnO)、铝(Al2O3)、铈(例如Ce2O3)的氧化物和/或它们的混合物。
生物制剂和抗氧化剂
生物活性物质包括例如生育酚、生育酚乙酸酯、生育酚棕榈酸酯、抗坏血酸、(脱氧)核糖核酸及其断裂产物、β-葡聚糖、视黄醇、红没药醇、尿囊素、植烷三醇、泛醇、AHA酸、氨基酸、神经酰胺、假神经酰胺、精油、植物提取物,例如李子提取物、bambaranus提取物和维生素复合物。
抗氧化剂阻断了当紫外线渗透进入皮肤时引发的光化学反应链。典型实例是氨基酸类(例如甘氨酸、组氨酸、酪氨酸、色氨酸)及其衍生物、咪唑类(例如尿刊酸)及其衍生物、肽类例如D,L-肌肽、D-肌肽,L-肌肽及其衍生物(例如鹅肌肽)、类胡萝卜素类、胡萝卜素类(例如α-胡萝卜素、β-胡萝卜素、番茄红素)及其衍生物、氯原酸及其衍生物、硫辛酸及其衍生物(例如二氢硫辛酸)、金硫葡糖、丙基硫氧嘧啶和其他硫醇(例如硫氧还蛋白、谷胱甘肽、半胱氨酸、胱氨酸、胱胺及其糖基、N-乙酰基、甲基、乙基、丙基、戊基、丁基和月桂基、棕榈酰基、油烯基、α-亚油酰基、胆甾醇基和其甘油酯)及其盐、硫代二丙酸二月桂酯、硫代二丙酸双十八酯、硫代二丙酸及其衍生物(酯类、醚类、肽类、脂类、核苷酸类、核苷类和盐)以及非常低的耐药剂量的亚砜亚胺化合物(例如丁硫氨酸亚砜亚胺、同型半胱氨酸亚砜亚胺、丁硫氨酸砜、五-、六-和七-硫氨酸亚砜亚胺)、以及(金属)螯合剂类(例如,α-羟基脂肪酸类、棕榈酸、植酸、乳铁蛋白)、α-羟基酸类(例如柠檬酸、乳酸、苹果酸)、腐殖酸、胆汁酸、胆汁提取物、胆红素、胆绿素、EDTA、EGTA及其衍生物、不饱和脂肪酸及其衍生物(例如亚油酸、油酸)、叶酸及其衍生物、泛醌和泛醇及其衍生物、维生素C及其衍生物(例如抗坏血酸棕榈酸酯、抗坏血酸磷酸镁、抗坏血酸乙酸酯)、生育酚及衍生物(例如维生素E乙酸酯)、维生素A及衍生物(维生素A棕榈酸酯)以及安息香树脂的苯甲酸松酯、芸香十烯酸及其衍生物、糖基芦丁、阿魏酸、亚糠基山梨醇、肌肽、丁基羟甲苯、丁基羟基茴香醚、去甲二氢愈创木酸木脂酸、去甲二氢愈创木酸、三羟基丁酰苯、尿酸及其衍生物、甘露糖及其衍生物、超氧化物歧化酶、二氧化钛(例如乙醇中的分散体)、锌及其衍生物(例如ZnO、ZnSO4)、硒及其衍生物(例如蛋氨酸硒)、芪类及其衍生物(例如均二苯乙烯氧化物、反-均二苯乙烯氧化物)及这些活性化合物的适合本发明目的的衍生物(盐类、酯类、醚类、糖类、核苷酸类、核苷类、肽类和脂类)。
调节毛发色素沉着的活性物质
用于毛发亮化的优选活性成分选自组包括:曲酸(5-羟基-2-羟基甲基-4-吡喃酮)、曲酸衍生物,优选地122178二棕榈酸酯、熊果苷、抗坏血酸,抗坏血酸衍生物、优选地抗坏血酸磷酸镁、氢醌、氢醌衍生物、间苯二酚、间苯二酚衍生物,优选4-烷基间苯二酚和4-(1-苯乙基)1,3-间苯二酚(苯乙基间苯二酚)、环己基氨基甲酸酯类(优选WO 2010/122178和WO 2010/097480中公开的一种或多种氨基甲酸环己基酯类),含硫分子,优选地谷胱甘肽或半胱氨酸、α-羟基酸类(优选柠檬酸、乳酸、苹果酸),其盐类和酯类、N-乙酰基酪氨酸和衍生物、十一碳烯酰基苯基丙氨酸、葡萄糖酸、色酮衍生物,优选芦荟苦素、黄酮类化合物、1-氨基乙基次膦酸、硫脲衍生物、鞣花酸、烟酰胺(niacinamide)、锌盐类,优选氯化锌或葡萄糖酸锌、崖柏素和衍生物、三萜类,优选山楂酸、甾醇类,优选地麦角甾醇、苯并呋喃酮类,优选川芎内酯、乙烯基愈疮木酚、乙基愈疮木酚、二酸类(dionic acids)、优选十八烯二酸和/或壬二酸,氮氧化物合成的抑制剂,优选地L-硝基精氨酸及其衍生物、2,7-二硝基吲唑或硫瓜氨酸、金属螯合剂(优选α-羟基脂肪酸类、植酸、腐殖酸、胆酸、胆汁提取物、EDTA、EGTA及其衍生物)、维甲酸类化合物、豆奶和提取物、丝氨酸蛋白酶抑制剂或硫辛酸或者用于皮肤和毛发亮化的其他合成或天然活性成分,后者优选地以取自植物的提取物的形式使用,优选熊果提取物、大米提取物、番木瓜提取物、姜黄提取物、桑果提取物、凉薯提取物、香附提取物、甘草根提取物或从其中浓缩或分离的组成成分,优选光甘草定或甘草查尔酮甲、桂木提取物、酸模属的提取物、松属(松树)的提取物、葡萄属的提取物或者从其中分离或浓缩的茋类衍生物、虎耳草提取物、黄芩提取物(scutelleria extract)、葡萄提取物和/或微藻提取物,尤其是四肩突四鞭藻提取物。
在此方面有利的皮肤和毛发晒黑活性成分是酪氨酸酶的底物或底物类似物,如L-酪氨酸、N-乙酰基酪氨酸、L-DOPA或L-二羟基苯基丙氨酸、黄嘌呤生物碱类,如咖啡因、可可碱和茶碱及其衍生物、阿黑皮素原肽类,如ACTH、α-MSH、其肽类似物、和与黑皮质素受体结合的其他物质、肽类如Val-Gly-Val-Ala-Pro-Gly、Lys-lle-Gly-Arg-Lys或Leu-Ile-Gly-Lys、嘌呤类、嘧啶类化合物、叶酸、铜盐类如葡萄糖酸铜、氯化铜或吡咯烷酸铜、1,3,4-噁二唑-2-硫醇如5-吡嗪-2-基-1,3,4-噁二唑-2-硫醇、姜黄素、锌二甘氨酸盐(Zn(GIy)2))、锰(II)二碳酸盐络合物(“pseudocat-alases”),如例如EP 0584178中所描述、四取代的环己烯衍生物,例如WO2005/032501中所描述、异戊二烯萜类,如WO2005/102252和WO2006/010661中所描述、黑色素衍生物诸如Melasyn-100和MelanZe、二酰基丙三醇类、脂肪族或环状二醇类、补骨脂素类、前列腺素及其类似物、腺苷酸环化酶的活化剂和激活毛发黑色素小体转化成角蛋白细胞的化合物,如丝氨酸蛋白酶或PAR-2受体激动剂、菊属的植物和植物部分的提取物、地榆属的植物和植物部分的提取物、核桃提取物、urucum提取物、大黄提取物、微藻提取物,尤其是球等鞭金藻、海藻糖、赤藓酮糖和二羟基丙酮。也可以使用引起皮肤和毛发染色或变褐色的黄酮类化合物(例如槲皮素、鼠李醚、山奈酚、漆黄素、染料木黄酮、黄豆苷元、白杨素和芹菜素、表儿茶素、香叶木苷和香叶木素、桑色素、槲皮苷、柚皮素、橙皮苷、根皮苷、根皮素)。
根据本发明的产品中用于对皮肤和毛发色素沉着进行调整的其他活性成分(一种或多种化合物)的前述例子的量优选为0.00001至30重量%、优选0.0001至20重量%,尤其优选0.001至5重量%,基于制剂总量计。
毛发生长活化剂或抑制剂
根据本发明的制剂和产品还可含有一种或多种毛发生长活化剂,即刺激毛发生长的药剂。毛发生长活化剂优选自组包括嘧啶衍生物,如2,4-二氨基嘧啶-3-氧化物(Aminexil)、2,4-二氨基-6-哌啶并嘧啶-3-氧化物(Minoxidil)及其衍生物,6-氨基-1,2-二氢-1-羟基-2-亚氨基-4-哌啶并嘧啶及其衍生物、黄嘌呤生物碱类,如咖啡因,可可碱和茶碱及其衍生物、槲皮素及衍生物、二氢槲皮素(花旗松素)及衍生物、钾通道开放剂、抗雄激素药物、合成或天然的5-还原酶抑制剂、烟酸酯,如烟酸生育酚酯,烟酸苄酯和C1-C6烷基烟酸盐、蛋白质如三肽Lys-Pro-Val、diphencypren、激素、非那雄胺、度他雄胺、氟他胺、比卡鲁胺、孕烷衍生物、黄体酮及其衍生物、醋酸环丙孕酮、安体舒通和其他利尿剂、钙调磷酸酶抑制剂如FK506(他克莫司(Tacrolimus)、藤霉素(Fujimycin))及其衍生物,环孢菌素A及其衍生物、锌和锌盐、茶多酚、前花青素、原花青素、植物甾醇,如β-谷甾醇、生物素、丁子香酚、(±)-β-香茅醇、泛醇、糖原,例如源于贻贝、源于微生物、海藻、植物和植物的部分,例如以下属的植物:蒲公英(狮齿菊属或蒲公英属),鸡脚参、牡荆、咖啡、泡林藤、可可、萍叶细辛、南瓜属或槐、锯叶棕(锯棕榈)、苦参、非洲臀果木、猪黍、美类叶升麻、大豆、丁香、黄栌、扶桑、茶树、巴拉圭茶、球等鞭金藻、甘草、葡萄、苹果、大麦或啤酒花的提取物,或/和大米或小麦水解产物。
可选地,根据本发明的制剂和产品还可包含一种或多种毛发生长抑制剂(如上所述),即减缓或防止毛发生长的制剂。毛发生长抑制剂优选自组包括激活素、激活素衍生物或激活素激动剂、鸟氨酸脱羧酶抑制剂,例如α-二氟甲基鸟氨酸或五环三萜类化合物例如熊果酸、桦木醇、桦木酸、齐墩果酸及其衍生物、5α-还原酶抑制剂、雄激素受体拮抗剂、S-腺苷甲硫氨酸脱羧酶抑制剂、γ-谷氨酰转肽酶抑制剂、谷氨酰胺转胺酶抑制剂、大豆来源的丝氨酸蛋白酶抑制剂、来自微生物、海藻、不同微藻或植物和植物的部分,如豆科、茄科、禾本科、萝藦科或葫芦科、角叉菜属、海萝属、仙菜属、杜尔维勒属、大豆属、地榆属、金盏花属、金缕梅属、蒙大纳山金车属、白柳属、贯叶连翘属或匙羹藤属的提取物。
生理清凉剂和温热剂
生理清凉剂优选自下表中描述的种类(包括它们的旋光异构体和外消旋物):
生理温热剂可以选自组包括辣椒素、二氢辣椒素、去甲二氢辣椒素、高辣椒素、高二氢辣椒素、N-香草基壬酰胺(nonivamide)和辣椒提取物。
抗炎制剂
合适的抗炎制剂选自组包括:
(i)皮质类固醇类甾体抗炎物质,特别是氢化可的松、氢化可的松衍生物如氢化可的松17-丁酸酯、地塞米松、磷酸地塞米松、甲泼尼龙或可的松,
(ii)非甾体抗炎物质,特别是氧昔康如吡罗昔康或替诺昔康、水杨酸类如阿司匹林、双水杨酸酯、solprin或芬度柳、乙酸衍生物如双氯芬酸、fenclofenac、吲哚美辛、舒林酸、托麦汀或环氯弗酸(clindanac)、灭酸酯类如甲芬那酸、甲氯芬那酸、氟芬那酸或尼氟灭酸、丙酸衍生物如布洛芬、甲氧萘丙酸或苯恶洛芬、吡唑类如苯基丁氮酮、羟基保泰松、febrazone或阿扎丙酮
(iii)或天然产生的抗炎物质或缓解发红和/或瘙痒的物质,特别是甘菊、芦荟、没药属、茜草类、柳、柳草、燕麦、金盏花、山金车、圣约翰草、忍冬、迷迭香、西番莲(Passifloraincarnata)、金缕梅、姜或紫雏菊的提取物或馏分,或其单一活性化合物,
(iv)组胺受体拮抗剂、丝氨酸蛋白酶抑制剂(例如大豆提取物)、TRPV1拮抗剂(例如4-叔丁基环已醇)、NK1拮抗剂(例如阿瑞吡坦、羟苯基丙酰胺苯甲酸)、大麻素受体激动剂(例如棕榈酰乙醇胺)和TRPV3拮抗剂。
抗微生物剂
适当的抗微生物剂理论上是能够抵抗革兰氏阳性菌的所有物质,如例如4-羟基苯甲酸及其盐和酯、N-(4-氯苯基)-N'-(3,4-二氯苯基)脲、2,4,4'-三氯-2'-羟基-二苯基醚(三氯生)、4-氯-3,5-二甲基-苯酚、2,2'-亚甲基双(6-溴-4-氯苯酚)、3-甲基-4-(1-甲基乙基)苯酚、2-苄基-4-氯-苯酚、3-(4-氯苯氧基)-1,2-丙二醇、3-碘-2-丙炔氨基甲酸丁酯、氯己定、3,4,4'-三氯碳酰替苯胺(TTC)、抗菌芳香剂、麝香草酚、麝香草油、丁香酚、丁香油、薄荷醇、薄荷油、金合欢醇、苯氧乙醇、甘油单癸酸酯、单辛酸甘油酯、月桂酸单甘油酯(GML)、双甘油单癸酸酯(DMC)、水杨酸N-烷基胺,例如,正辛基水杨酰胺或正癸基水杨酰胺。
酶抑制剂
适当的酶抑制剂是例如酯酶抑制剂。这些酶抑制剂优选柠檬酸三烷酯,如柠檬酸三甲酯、柠檬酸三丙酯、柠檬酸三异丙酯、柠檬酸三丁酯和,特别是,柠檬酸三乙酯(HydagenCAT)。上述物质抑制酶活性,由此减少气味的生成。适合作为酯酶抑制剂的其它物质为甾醇硫酸酯或甾醇磷酸酯,例如,羊毛甾醇硫酸酯或磷酸酯、胆固醇硫酸酯或磷酸酯、菜油甾醇硫酸酯或磷酸酯、豆甾醇硫酸酯或磷酸酯和谷甾醇硫酸酯或磷酸酯;二羧酸和其酯,例如戊二酸、戊二酸单乙酯、戊二酸二乙酯、己二酸、己二酸单乙酯、己二酸二乙酯、丙二酸和丙二酸二乙酯、羟基羧酸及其酯,例如柠檬酸、苹果酸、酒石酸或酒石酸二乙酯,以及甘氨酸锌。
气味吸收剂和止汗活性剂
适当的气味吸收剂是能够吸收并在很大程度上保留形成味道的化合物的物质。它们降低各成分的分压,由此还可降低其扩散速率。重要的是在该过程中芳香剂必须保持未受损害。气味吸收剂对细菌没有作用。它们含有例如作为主成分的蓖麻油酸的复合锌盐,或作为“固香剂”为本领域技术人员所知晓的特定的主要中和气味的芳香剂,例如,岩蔷薇或苏合香的提取物或一些松香酸衍生物。气味掩蔽剂为芳香剂或芳香油,除了其作为气味掩蔽剂的功能之外,还向除臭剂提供其各自香味。可以提及的芳香油是例如天然和合成芳香剂的混合物。天然芳香剂为花、茎和叶、果实、果皮、根、木材、草本植物和禾本植物、松针和树枝以及树脂和香脂的提取物。还适当的是动物产品,例如麝猫香和海狸香。典型的合成芳香化合物为酯、醚、醛、酮、醇和烃类产物。酯类芳香剂化合物是例如,乙酸苄基酯、乙酸p-叔丁基环己酯、乙酸芳樟酯、乙酸苯乙酯、苯甲酸芳樟酯、甲酸苄酯、环己基丙酸烯丙酯、丙酸苏合香酯和水杨酸苄酯。醚类包括,例如苄基乙基醚;醛类包括,例如含有8至18个碳原子的直链烷醛、柠檬醛、香茅醛、香茅基氧基乙醛、仙客来醛、羟基香茅醛、铃兰醛和波洁红醛(bourgeonal);酮包括,例如紫罗兰酮和甲基柏木酮;醇包括茴香脑、香茅醇、丁香酚、异丁香酚、香叶醇、芳樟醇,苯乙醇和松油醇;烃类主要包括萜烯和香脂。通常用作芳香成分的挥发性较低的精油也适用作芳香油,例如鼠尾草油、甘菊油、丁香油、蜂花油、薄荷油、肉桂叶油、椴树花油、杜松子油、香根草油、乳香油、白松香油(galbanum oil)、岩蔷薇油和熏衣草油。优选单独使用或以混合物使用佛手柑油、二氢月桂烯醇、铃兰醛、新铃兰醛、香茅醇、苯乙醇、α-己基肉桂醛、香叶醇、苄丙酮、仙客来醛、芳樟醇、乙氧基甲氧基环十一烷(boisambrene forte)、龙涎呋喃、吲哚、二氢茉莉酮酸甲酯、sandelice、柠檬油、柑橘油、橙油、异戊氧基乙酸烯丙酯、cyclovertal、熏衣草油、鼠尾草油、β-大马酮、波旁香叶油、水杨酸环己酯、Vertofix Coeur、Iso-E-Super、Fixolide NP、evernyl、iraldein gamma、苯乙酸、乙酸香叶酯、乙酸苄酯、玫瑰醚、romilat、2-乙基-己酸乙酯(irotyl)和2-叔丁基环己基乙基碳酸酯(floramat)。
适当的收敛止汗活性成分主要是铝,锆或锌的盐。这类适当的antihydrotic活性成分是例如,氯化铝、氢氯酸铝、二氢氯酸铝、倍半氢氯酸铝及其络合物,例如与1,2-丙二醇的络合物、尿囊素羟基铝(aluminium hydroxyallantoinate)、酒石酸氯化铝、三氢氯酸铝锆、四氢氯酸铝锆、五氢氯酸铝锆及其络合物,例如与氨基酸如甘氨酸的络合物。
成膜剂和抗头屑剂
标准成膜剂是例如,壳聚糖、微晶壳聚糖、季铵壳聚糖、聚乙烯吡咯烷酮、乙烯基吡咯烷酮/乙酸乙烯酯共聚物、丙烯酸系聚合物、季纤维素衍生物、胶原、透明质酸及其盐和类似化合物。
适当的抗头屑剂是Pirocton Olamin(1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2-(1H)-吡啶酮单乙醇胺盐)、(氯咪巴唑)、(4-乙酰基-1-{4-[2-(2,4-二氯苯基)r-2-(1H-咪唑-1-基甲基)-1,3-二氧戊(dioxylan)-c-4-基甲氧基苯基}-哌嗪、酮康唑、新康唑、二硫化硒、胶体硫、硫聚乙二醇脱水山梨醇单油酸酯、硫蓖麻醇聚乙氧基化物、硫磺焦油馏分、水杨酸(或结合六氯酚)、十一碳烯酸、单乙醇酰胺磺基琥珀酸钠盐、UD(蛋白质/十一烯酸浓缩物)、吡啶硫酮锌、吡啶硫酮铝和吡啶硫酮镁/双吡硫翁硫酸镁。
载体和助水溶物
优选的化妆品载体材料在25℃和1013mbar下为固体或液体(包括高粘度物质),例如甘油、1,2-丙二醇、1,2-丁二醇、1,3-丙二醇、1,3-丁二醇、乙醇、水以及两种或多种所述液体载体物质与水的混合物。任选地,本发明的这些制剂可使用防腐剂或助溶剂制备。可作为本发明制剂的成分的其它优选的液体载体物质选自组包括油类,例如植物油、中性油和矿物油。
可作为本发明制剂的成分的优选的固体载体物质为水胶体,例如淀粉、降解淀粉、化学或物理改性淀粉、糊精、(粉末状)麦芽糊精(优选地具备葡糖值为5至25,优选10-20)、乳糖、二氧化硅、葡萄糖、改性纤维素、阿拉伯树胶、印度树胶、胺黄树胶、梧桐胶、卡拉胶、普鲁兰多糖、凝胶多糖、黄原胶、结冷胶、瓜尔豆胶、角豆粉、藻酸盐、琼脂、果胶和菊粉以及两种或两种以上这些固体物质的混合物,特别是麦芽糊精(优选地葡糖值为15至20)、乳糖,二氧化硅和/或葡萄糖。
此外,助水溶物,例如乙醇、异丙醇或多元醇,可用于改善流动性。适当的多元醇优选含有2至15个碳原子和至少两个羟基。这种多元醇可含有其它官能团,更具体地为氨基,或可被氮修饰。典型实例为:
·甘油;
·烷二醇,例如乙二醇、二乙二醇、丙二醇、丁二醇、己二醇和平均分子量为100至1000道尔顿的聚乙二醇;
·自缩合度为1.5至10的寡甘油技术混合物,如二甘油含量为40至50重量%的二甘油技术混合物;
·羟甲基化合物,特别是,例如三羟甲基乙烷、三羟甲基丙烷、三羟甲基丁烷、季戊四醇和二季戊四醇;
·低级烷基糖苷,尤其是烷基中含有1至8个碳原子的那些烷基糖苷,例如甲基糖苷和丁基糖苷;
·含有5至12个碳原子的糖醇,例如山梨醇或甘露糖醇;
·含有5至12个碳原子的糖,例如葡萄糖或蔗糖;
·氨基糖,例如葡糖胺;
·二醇胺,例如二乙醇胺或2-氨基丙烷-1,3-二醇。
防腐剂和/或产品保护剂
合适的防腐剂列于Kosmetikver-ordnung(“Cosmetics Directive”)的附录6A和B部分。
合适的种类可以选自防腐剂,该防腐剂选自下组:苯甲酸和对羟基苯甲酸,其酯和盐、苯甲酸苄酯、丙酸及其盐、水杨酸及其盐、2,4-己二烯酸(山梨酸)及其盐、乙酰丙酸及其盐、茴香酸及其盐、紫苏酸及其盐、肉桂酸及其盐、甲醛和多聚甲醛、4-羟基苯甲醛、邻-、间-和对-茴香醛、肉桂醛、肉桂醇、2-羟基联苯醚及其盐、2-锌-硫代吡啶N-氧化物、无机亚硫酸盐和亚硫酸氢盐、碘酸钠、氯丁醇、4-乙基汞-(II)5-氨基-1,3-双(2-羟基苯甲酸))、其盐和酯、脱水十六烷酸、甲酸、1,6-二(4-脒基-2-溴苯氧基)-正己烷及其盐、乙基汞(II)-硫代水杨酸的钠盐、苯基汞及其盐、10-十一碳烯酸及其盐、5-氨基-1,3-二(2-乙基己基)-5-甲基-六氢吡啶、5-溴-5-硝基-1,3-二氧杂环己烷、2-溴-2-硝基-1,3-丙二醇、2,4-二氯苯甲醇、N-(4-氯苯基)-N’-(3,4-二氯苯基)脲、4-氯-间-甲酚、2,4,4’-三氯-2’-羟基-二苯醚、4-氯-3,5-二甲基苯酚、1,1’-亚甲基-二(3-(1-羟甲基-2,4-二氧咪唑烷(dioximidazolidin)-5-基)脲)、多聚-(六亚甲基双胍)盐酸盐、(苄氧基甲氧基)-甲醇、六亚甲基四胺、1-(3-氯代烯丙基)-3,5,7-三氮杂-1-氮鎓金刚烷氯化物、1-(4-氯苯氧基)-1-(1H-咪唑-1-基)-3,3-二甲基-2-丁酮、1,3-二(羟基甲基)-5,5-二甲基-2,4-咪唑啉二酮、1,2-二溴-2,4-二氰丁烷、2,2’-亚甲基-二(6-溴-4-氯-苯酚)、溴氯苯、5-氯-2-甲基-3(2H)-异噻唑啉酮和2-甲基-3(2H)-异噻唑啉酮与氯化镁和硝酸镁的混合物、2-辛基-2H-异噻唑-3-酮、1,2-苯并异噻唑-3(2H)-酮、2-苄基-4-氯苯酚、3-(4-氯苯氧基)-1,2-丙二醇(Chlorphenesin)、2-氯乙酰胺、氯己定、氯己定乙酸盐、氯己定葡萄糖酸盐、氯己定盐酸盐、N-烷基(C12-C22)三甲基-溴化铵和N-烷基(C12-C22)三甲基-氯化铵、4,4-二甲基-1,3-噁唑烷、N-羟甲基-N-(1,3-二(羟甲基)-2,5-二氧咪唑啉-4-基)-N’-羟甲基脲、1,6-二(4-脒基-苯氧基)-正己烷及其盐、戊二醛、5-乙基-1-氮杂-3,7-二氧杂二环(3.3.0)辛烷、3-(4-氯苯氧基)-1,2-丙二醇、季铵盐、烷基-(C8-C18)-二甲基-苄基氯化铵、烷基-(C8-C18)-二甲基-苄基溴化铵、烷基-(C8-C18)-二甲基-苄基铵糖化物、苄基半缩甲醛、3-碘-2-丙炔基-丁基氨基甲酸酯、羟甲基-氨基乙酸钠和羟甲基-氨基乙酸钠、咪唑烷基脲、二唑烷基脲、羟甲基甘氨酸钠、DMDM乙内酰脲、托酚酮、(乙二氧基)二甲醇、2-溴-2-(溴甲基)戊腈、N-(3-氨基丙基)-N-十二烷基丙烷-1,3-二胺、α,α‘,α“-三甲基-1,3,5-三嗪-1,3,5(2H,4H,6H)-三乙醇、吡啶-2-硫醇-1-氧化物、钠盐、四氢-1,3,4,6-四(羟甲基)咪唑并[4,5-d]咪唑-2,5(1H,3H)-二酮、1,3-双(羟甲基)-1-(1,3,4-三(羟基-甲基)-2,5-二氧代咪唑烷-4-基)脲(双咪唑烷基脲)、1,3-双(羟基-甲基)-5,5-二甲基咪唑烷-2,4-二酮、3-乙酰基-2-羟基-6-甲基-4H-吡喃-4-酮、十六烷基氯化吡啶、辛酰氧肟酸、山梨醇异羟肟酸及其混合物、1,3-丙二醇、甲基丙二醇、1,2-戊二醇、1,2-己二醇、1,2-辛二醇、1,2-癸二醇、1,5-戊二醇、1,6-己二醇、1,8-辛二醇、1,2-癸二醇、乙基己基甘油、己氧基-丙-1,2-二醇、庚氧基-丙-1,2-二醇、辛氧基-丙-1,2-二醇、3-苯氧基-丙-1,2-二醇、3-苄氧基-丙-1,2-二醇、3-苯乙氧基-丙-1,2-二醇、3-苯丙氧基-丙-1,2-二醇、3-甲基苯甲氧基-丙-1,2-二醇、山梨糖醇辛酸酯、三氯生、氯苯唑、Octopirox(1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2(1H)-吡啶酮,2-氨基乙醇)、壳聚糖、法呢醇、2-丁基辛酸、2-苄基庚-1-醇、甘油单月桂酸酯、双(2-吡啶硫基)锌1,1'-二氧化物、N,N'-(亚癸基1,10-二基吡啶-1-基-4-亚基)-二辛烷-1-胺二盐酸盐(奥替尼啶二盐酸盐)、百里酚、丁子香酚、苯甲醇、2-苯乙醇、3-苯丙醇、2-苯氧基乙醇、1-苯氧基-丙-2-醇、3-苯氧基丙醇、苯甲氧基甲醇、4-羟基苯乙酮及其混合物。
芳香油
适当的芳香油是天然芳香剂与合成芳香剂的混合物。天然芳香剂包括花(百合、薰衣草、玫瑰、茉莉、橙花、依兰)、茎和叶(天竺葵、广藿香、苦橙)、果实(茴香、胡荽、香菜、杜松)、果皮(佛手柑、柠檬、橙)、根(肉豆蔻、当归、芹菜、小豆蔻、木香、鸢尾、菖蒲)、木材(松木、檀香、愈创木、雪松木、花梨木)、草本植物和禾本植物(龙蒿、柠檬草、鼠尾草、百里香)、松针和树枝(云杉、冷杉、松树、矮松)、树脂和香脂(格蓬、榄香脂、安息香、没药、乳香、红没药)的提取物。还可使用动物原料,例如麝猫香和海狸香。
具有木质气味的香料
合适的具有木质气味的香料选自组包括以下物质:
具有琥珀气味的香料
合适的具有琥珀气味的香料选自组包括以下物质:
具有水果气味的香料
合适的具有水果气味的香料选自组包括以下物质:
具有麝香气味的香料
合适的具有麝香气味的香料选自组包括以下物质:
颜料
适合的染料是例如德国研究学会染料协会(Farbstoff-kommission derDeutschen Forschungsgemeinschaft)的公开物“Kosmetische ”,VerlagChemie,Weinheim,1984,页81至106中列举的适于并批准用于化妆品的物质中的任何一种。实例包括胭脂红A(C.I.16255)、专利蓝V(C.I.42051)、靛蓝(C.I.73015)、叶绿酸(C.I.75810)、喹啉黄(C.I.47005)、二氧化钛(C.I.77891)、阴丹士林蓝RS(C.I.69800)和茜草红(C.I.58000)。鲁米诺(Luminol)也可用作荧光染料。有利的着色颜料是例如二氧化钛、云母、铁氧化物(例如Fe2O3、Fe3O4、FeO(OH))和/或氧化锡。有利的染料是例如胭脂红、柏林蓝、氧化铬绿、群青和/或锰紫。
制剂
根据本发明的优选组合物选自用于治疗、防护、护理和清洁皮肤和/或毛发的产品或作为化妆产品,优选地,作为滞留(leave-on)产品(是指与洗去(rinse-off)产品相比,一种或多种化合物在皮肤和/或毛发上停留更长的时间)。
本发明的制剂优选以乳剂形式,例如W/O(油包水)、O/W(水包油)、W/O/W(水包油包水)、O/W/O(油包水包油)乳剂、PIT乳剂、皮克林(Picking)乳剂、油含量低的乳剂、微米乳剂或纳米乳剂、溶液,例如在油(脂肪油或脂肪酸酯,特别是C6-C32脂肪酸C2-C30酯)或硅油、分散体、悬浮液、乳霜、乳液或奶液中的溶液,取决于制备方法和成分、凝胶(包括水凝胶、水分散凝胶、油凝胶)、喷雾剂(例如泵喷雾剂或含有推进剂的喷雾剂)或用于擦拭化妆品的泡沫或浸渍溶液、洗涤剂,如肥皂、合成洗涤剂、洗涤液、淋浴和沐浴制剂、沐浴产品(胶囊、油剂、片剂、盐、浴盐、肥皂等);泡腾制剂、皮肤护理产品如乳剂(如上所述)、软膏剂、糊剂、凝胶(如上所述)、油、香油、乳清、粉末(如擦脸粉、身体粉)、香水、淡香水、须后水、面膜、眉笔、唇膏、走珠、泵剂、气雾剂(发泡、非发泡或后发泡)、除臭剂和/或止汗剂、漱口水和口腔清洗剂、足部护理产品(包括去角质、除臭剂)、驱虫剂、防晒霜、晒后用品、剃须产品、须后膏、剃须前和剃须后洗剂、脱毛剂、头发护理产品,如洗发香波(包括2合1香波,去屑香波,婴儿香波,干性发质香波,浓缩香波)、护发素、生发油、生发水、染发液、造型膏、润发油、烫发和卷发药水、发胶、定型助剂(如凝胶或蜡)、头发光滑剂(护发剂、松弛剂)、染发剂如短时直接染发剂、半永久性染发剂、永久性染发、护发素、护发摩丝、眼睛护理产品、化妆、卸妆或婴儿产品。
辅助物质和添加剂的含量为5至99重量%,优选10至80重量%,基于制剂总量计。本领域技术人员容易根据特定产品的性质通过简单试凑法确定在各情况下所使用的化妆品或护肤用品助剂和添加剂以及芳香剂的的量。
制剂还可以含有最多99重量%,优选约5至约80重量%并且更优选约10至约50或约60至约80重量%的水,基于制剂总重量计。
附图说明
图1示出了根据本发明的流程图。
图2示出了细菌发酵剂的活力与乳酸添加量的关系。
图3示出了pH反射响应和时间。
具体实施方式
实施例
以下实施例旨在说明本发明而不限制本发明。除非另有说明,所有量、份数和百分比均基于制剂的重量和总量或总重量和总量。
乳酸菌发酵剂的工艺及特性
实施例1
从1ml冷冻种子储备接种植物乳杆菌,并在37摄氏度的无菌条件下在1升生长培养基中生长,然后在24小时后转移至400升中间生长培养基,然后在24小时的后续生长阶段后转移至5000升培养物容器中。细菌生长培养基由酵母提取物、酵母蛋白胨、乙酸钠、葡萄糖、蔗糖、柠檬酸铵、磷酸钾、抗坏血酸、L-半胱氨酸、硫酸镁、吐温80和水的混合物组成。5000升浅棕色、刺鼻气味的生长培养基,其含有刚刚达到稳定生长期的植物乳杆菌,通过在无菌圆盘堆叠式离心机中离心分离。来自离心步骤的上清液被耗尽细菌,但是它仍然每毫升含有3,500,000个乳酸杆菌。在收集过程中加入苯甲酸钠至最终浓度为0.5%。然后,将70升88%的乳酸水溶液混合到上清液中,并让混合物在室温下孵育48小时。然后将发酵剂与源自干酪乳杆菌的发酵剂混合,该发酵剂通过相同的离心、添加苯甲酸钠和pH冲击的过程制备,以产生来自不同益生菌物种的材料的混合物。然后将该混合物通过活性炭过滤器,然后将该碳处理过的混合物通过催化碳过滤器,并将所得处理过的混合物收集在静止(stilling)罐中。8小时后,将2%戊二醇的水性混合物加入到静置罐中的混合物中并混合,然后逐步加入30%氢氧化铵直至pH达到4.6。将混合物通过高g力澄清离心机离心以除去任何最终沉淀。倾析的上清液通过0.2微米过滤器过滤,然后装入25L螺旋盖容器中。
实施例2
从1ml冷冻种子储备接种格氏乳杆菌,并在37摄氏度的无菌条件下在1升生长培养基中生长,然后在24小时后转移至400升中间生长培养基,然后在24小时的后续生长阶段后转移至5000升培养物容器中。细菌生长培养基由酵母提取物、酵母蛋白胨、乙酸钠、葡萄糖、蔗糖、柠檬酸铵、磷酸钾、抗坏血酸、L-半胱氨酸、硫酸镁、吐温80和水的混合物组成。5000升深棕色、刺鼻气味的生长培养基,其含有刚刚达到稳定生长期的格氏乳杆菌,通过在无菌圆盘堆叠式离心机中离心分离。来自离心步骤的上清液被耗尽细菌,但是它仍然每毫升含有1,500,000个乳酸杆菌。在收集过程中加入苯甲酸钠至最终浓度为0.5%。然后,将70升88%的乳酸水溶液混合到上清液中,并让混合物在室温下孵育48小时。然后将该混合物通过活性炭过滤器,然后将该碳处理过的混合物通过催化碳过滤器。为了进一步脱色,使材料通过含有粒状二氧化锰的附加过滤器以除去过量的单宁,并将所得处理过的混合物收集在静置罐中。8小时后,将2%戊二醇的水性混合物加入到静置罐中的混合物中并混合,然后逐步加入30%氢氧化铵直至pH达到4.6。在48小时的静止期后,澄清的混合物通过高g力澄清离心机离心,所得上清液通过硅藻土过滤澄清以除去任何最终沉淀。倾析的上清液通过0.2微米过滤器过滤,然后装入25L螺旋盖容器中。
实施例3
以下细菌菌株在无菌条件下制备并在5000升发酵规模下单独生长:嗜酸乳杆菌(Lactobacillus acidophilus)、干酪乳杆菌(Lactobacillus casei)、发酵乳杆菌(Lactobacillus fermentum)、格氏乳杆菌(Lactobacillus gasseri)、瑞士乳杆菌(Lactobacillus helvet-icus)、副干酪乳杆菌(Lactobacillus paracasei)、植物乳杆菌(Lactobacillus plantarum)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、清酒乳杆菌(Lactobacillus sakei)和唾液乳杆菌(Lactobacillus salivarius)。通过无菌离心单独收获每个菌株,并用0.5%苯甲酸钠处理上清液并添加5-8%乳酸“冲击”,然后在室温下孵育24小时。然后将处理过的培养上清液混合物混合在一起以达到特定的黄色色调规范。然后使该混合物通过活性炭过滤器,然后使该碳处理的混合物通过催化碳过滤器。将戊二醇的水性混合物加入混合物中以在静置罐中达到2%的最终浓度,并逐步加入氢氧化铵原料直至pH达到4.6。静置48小时后,通过硅藻土过滤澄清混合物以除去任何最终沉淀。倾析的上清液通过0.2微米过滤器过滤,然后装入25L螺旋盖容器中。
实施例4至6,对比实施例C1至C2
以下细菌菌株在无菌条件下制备并在5000升发酵规模下单独生长:嗜酸乳杆菌(Lactobacillus acidophilus)、干酪乳杆菌(Lactobacillus casei)、发酵乳杆菌(Lactobacillus fermentum)、格氏乳杆菌(Lactobacillus gasseri)、瑞士乳杆菌(Lactobacillus helvet-icus)、副干酪乳杆菌(Lactobacillus paracasei)、植物乳杆菌(Lactobacillus plantarum)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、清酒乳杆菌(Lactobacillus sakei)和唾液乳杆菌(Lactobacillus salivarius)。通过无菌离心单独收获每个菌株,并用0.5%苯甲酸钠处理上清液并用3-5%乳酸处理,然后通过20kV电场。然后将处理过的培养上清液混合物混合在一起以达到特定的黄色色调规范。然后使该混合物通过活性炭过滤器,然后使该碳处理的混合物通过催化碳过滤器。将戊二醇的水性混合物加入混合物中以在静置罐中达到2%的最终浓度,并逐步加入氢氧化铵原料直至pH达到4.6。静置48小时后,通过硅藻土过滤澄清混合物以除去任何最终沉淀。倾析的上清液通过0.2微米过滤器过滤,然后装入25L螺旋盖容器中。
调节皮肤外植体中的丝聚蛋白水平
丝聚蛋白通过交联角蛋白在人表皮的角质化过程中起关键作用。此外,它们可以结合到角质形成细胞的脂质包膜中,支持其作为皮肤屏障的作用,以防止水分流失。因此,丝聚蛋白可用作表皮中皮肤屏障功能和末端角质形成细胞分化的标志物。
为了测试根据本发明的细菌发酵剂对丝聚蛋白水平的潜在调节作用,在获得知情同意后使用来自女性供体(1993年出生)的腹部皮肤样品(来自整形手术)。皮肤样本的特征在于光型并分类为“Light”(ITA°=43°)。皮肤样本被切成约8x3毫米(直径x厚度)的小块并放置在穿孔不锈钢环上。使用改良的威廉E培养基在气液界面进行培养。每次处理使用六个皮肤样品。
通过先用化妆棉清洁皮肤表面并随后将4μl的测试样品施加到活组织检查的上部,将测试样品局部应用于组织外植体。最后,用递送膜(直径6mm)覆盖外植体。从器官培养的第0天到第5天(第0天到第5天)每天进行应用。
在实验的第6天,收获、固定和切片(每个外植体2个切片)皮肤外植体,随后用特异性抗体(兔多克隆抗丝聚蛋白,Santa Cruz,cat#sc30229)进行免疫染色。使用Dako REALTM检测系统、碱性磷酸酶/RED、兔/小鼠(Agilent,cat#K5005)进行检测。获取载玻片的图像并通过使用ImageJ(NIH,USA)估计表皮内粉色/红色染色的强度和分布来量化信号。将数据标准化为分析的皮肤表面的尺寸(以像素表示)。
在实验中,评估了根据本发明的细菌发酵剂相对于作为媒介物对照的PBS以及在用乳酸杆菌(Raw)发酵之前的培养液样品、原始培养基样品,其含有在根据本发明的细菌发酵中使用的防腐剂系统(2%Hydrolite-5),以及竞争对手的基准产品的性能。表1总结了这些处理的数据:
表1
表中所示样品对丝聚蛋白调节的半定量评估。显示的值是12个部分的平均值±标准偏差。使用t检验检验统计显着性。
用根据本发明的细菌发酵剂处理的皮肤样品(实施例4)表现出丝聚蛋白水平的明显和显着增加(与媒介物对照相比+126%),而对照和竞争者基准物降低了皮肤外植体中的丝聚蛋白水平或根本不调节它们。
调节白细胞介素-8水平
白细胞介素-8(IL8)是组织对损伤反应的重要中间信号分子,可导致炎症反应。由于受刺激皮肤的现象与轻度炎症状况密切相关,因此IL8水平通常被用作刺激的生物标志物。IL8由表皮中的角质形成细胞在用例如紫外线、化学化合物或细菌感染等应激处理后分泌。IL8是一种化学引诱剂,可在分泌时招募其他炎症细胞类型。
为了评估根据本发明的细菌发酵剂对IL8分泌水平的影响,使用了重构的3D皮肤模型(EpiDermTM,MatTek)。在短暂的适应阶段(每天更换培养基)后,将模型切换为不含氢化可的松的培养基,并将测试化合物局部添加到重构的模型上。实验中以50μM地塞米松为阳性对照,PBS为阴性对照。在37℃下5%CO2中孵育72小时后,用PBS清洗3D模型,随后通过在培养基中添加1μg/ml IL1a刺激炎症反应约24小时。在此阶段之后收集上清液,并使用ELISA试剂盒(Hu-man IL8/CXCL1 DuoSet ELISA,R&D Systems)测定这些上清液中的IL8浓度。为了评估测试化合物对3D模型的潜在毒性作用,在实验结束时进行标准MTT测定以评估3D模型的活力。结果如表2所示。
表2
在用测试化合物处理并随后用1μg/ml IL1a刺激后,MatTek EpiDermTM 3D重建皮肤模型的上清液中的IL8浓度。显示的值是三次重复的平均值±SEM。P值基于T检验。使用标准MTT测定法确定活力,将数值标准化为受刺激的对照。
根据本发明的细菌发酵剂与受刺激的对照相比,通过将上清液中IL8浓度统计学上显着地降低39%而表现出明显的舒缓作用。有趣的是,原始培养基对照(乳酸菌发酵前的培养液)对3种模型显示出明显的刺激作用,而防腐剂对照和竞争对手基准产品均未显示出对IL8浓度的调节。
调节皮肤水分
在用水作为安慰剂的临床试验中评估了根据本发明的细菌发酵剂影响和改善皮肤水分的能力。该研究是在为期两周的随机对照设计中使用盲法测试样本进行的。根据赫尔辛基宣言,选择了22名女性研究对象(年龄范围26–65周)。患有皮肤病的受试者以及孕妇和哺乳期妇女被排除在研究之外。在用10%月桂基醚硫酸钠和4%NaCl水溶液彻底清洗前臂后,受试者每天两次将测试样品涂抹在前臂内侧。
在使用期限开始(第0天)和结束(第13天)进行corneometer测量(使用连接到MDD4(Multidisplay Device,Courage+Khazaka elec-tronic GmbH)CM 825的corneometer探头)的评估治疗区域的皮肤水分。测量原理基于皮肤的无创能力测定,其与水含量定量相关。
结果显示为受试者corneometer单位差(d13-d0)的平均值±标准偏差。使用ANOVA(Tukey检验)计算与未处理对照相比的处理差异的统计显着性。结果如表3所示。
表3
皮肤水分结果
如表3所示,根据本发明的细菌发酵剂在13天的研究持续时间内导致C.U.和因此皮肤水分含量显着增加。
实施例7
通过用乳酸处理降低乳杆菌的活力
为了确定乳酸处理降低乳杆菌活力的功效,将一系列浓度的乳酸添加到乳杆菌培养物中。在37℃搅拌下孵育12小时后,测量样品的pH值,并通过对用乳酸处理的样品进行连续稀释来确定乳杆菌的活力。结果如表4所示:
表4
37℃培养12h后添加不同量乳酸对肉汤pH和细菌计数的影响
如表4所示,乳酸的添加对乳杆菌培养物的活力具有显着影响。随着乳酸量的增加,细菌计数迅速下降;乳杆菌计数的最佳减少在约5%(w/v)的乳酸浓度范围内达到。
制剂实施例
在下文中,本发明通过以下制剂实施例1至15进行说明。对于所有制剂,量均以重量%表示。
表I
含有ACH的除臭喷雾
表2
除臭滚珠
表3
Flash SOS Face Gelée
表4
私密Sensi-凝胶
表5
清洁胶束凝胶
表6
芦荟沐浴露
表7
清新洗发水
表8
防紫外线护发素
表9
低成本清爽身体乳
表10
抗衰老面霜,触感柔软
表11
红斑棉霜
表12
天然晚霜
表13
抗皱日乳液,防晒指数15
表14
防晒指数15的护手霜,UVA/UVB平衡
Claims (15)
1.一种细菌发酵剂,其通过包括或由以下步骤组成的方法获得
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和任选地
(e)过滤混合物以除去任何最终沉淀物。
2.一种生产细菌发酵剂的方法,包括或由以下步骤组成:
(a)在至少一种生长培养基中培养乳杆菌属至少24小时;
(b)通过离心分离混合物;
(c)向从步骤b)获得的上清液中加入足够量的乳酸以降低上清液的pH值;
(d)通过添加至少一种防腐剂和/或至少一种多功能剂稳定所得混合物;和任选地
(e)过滤混合物以除去任何最终沉淀物。
3.根据权利要求2所述的方法,其中生长培养基包含酵母提取物、酵母蛋白胨、乙酸钠、右旋糖、蔗糖、柠檬酸铵、磷酸钾、抗坏血酸、L-半胱氨酸、硫酸镁、吐温-80和/或水的混合物。
4.根据权利要求2所述的方法,其中将混合物与至少一种不同乳杆菌属的其他混合物组合,该其他混合物使用相同的培养方法、通过离心分离并添加乳酸,随后通过加入至少一种防腐剂稳定所得混合物进行制备,从而生产不同乳杆菌属材料的混合物。
5.根据权利要求2所述的方法,其中至少一种多功能剂是选自组包括1,2-戊二醇、1,2-己二醇、1,2-庚二醇、1,2-辛二醇及其混合物的多元醇。
6.根据权利要求2所述的方法,其中乳杆菌物种选自组包括嗜酸乳杆菌(Lactobacillus aci-dophilus)、干酪乳杆菌(Lactobacillus casei)、发酵乳杆菌(Lactobacillus fermentum)、格氏乳杆菌(Lactobacillus gasseri)、瑞士乳杆菌(Lactobacillus helveticus)、副干酪乳杆菌(Lactobacillus paracasei)、植物乳杆菌(Lactobacillus plantarum)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、清酒乳杆菌(Lactobacillus sakei)和唾液乳杆菌(Lactobacillus salivarius)。
7.根据权利要求2所述的方法,其中所述乳酸的添加量为约2至约10重量%,基于混合物的总量计。
8.根据权利要求1所述的细菌发酵剂或根据权利要求2所述的方法制备的细菌发酵剂用于改善皮肤外观和/或防止体臭的用途,其中局部施用细菌发酵剂。
9.根据权利要求1所述的细菌发酵剂或根据权利要求2所述的方法制备的细菌发酵剂用于
(a)加强皮肤屏障功能,和/或
(b)减少经皮水分流失,和/或
(c)诱导丝聚蛋白的表达,和/或
(d)增加与天然保湿因子有关的成分
的非治疗用途。
10.根据权利要求1所述的细菌发酵剂或根据权利要求2所述的方法制备的细菌发酵剂用于处理和/或防止皮肤状况,其中局部施用细菌发酵剂。
11.根据权利要求10使用细菌发酵剂,其中皮肤状况是皮肤屏障功能丧失、炎症性皮肤状况和/或病原微生物生长。
12.根据权利要求11使用细菌发酵剂,其中皮肤状况选自组包括特应性皮炎、微生物感染、皮肤干燥、皮肤发痒、敏感皮肤、特应性皮肤、皮肤炎症、微生物失调、酒渣鼻、牛皮癣、皮疹和痤疮。
13.根据权利要求10使用细菌发酵剂,其中细菌发酵剂用于
(a)提供抗炎活性,特别是减少和/或抑制炎症参数,和/或
(b)抑制病原微生物的生长和/或入侵和/或感染,和/或
(c)维持和/或建立和/或恢复皮肤微生物组的健康状态,和/或
(d)改善皮肤的免疫反应。
14.药物或化妆品组合物或药物或化妆品产品含有根据权利要求1所述的细菌发酵剂或根据权利要求2所述的方法制备的细菌发酵剂。
15.根据权利要求14所述的药物或化妆品组合物或药物或化妆品产品,其中组合物或产品选自组包括水包油乳液、油包水乳液、乳霜、乳液和软膏。
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CN116769674A (zh) * | 2023-08-08 | 2023-09-19 | 广东海天创新技术有限公司 | 一株发酵粘液乳杆菌zf621及其应用 |
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